Organism : Bacillus cereus ATCC14579 | Module List :
BC2526

Transcriptional regulator, GntR family (NCBI ptt file)

CircVis
Functional Annotations (7)
Function System
Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs cog/ cog
sequence-specific DNA binding transcription factor activity go/ molecular_function
intracellular go/ cellular_component
regulation of transcription, DNA-dependent go/ biological_process
biosynthetic process go/ biological_process
transferase activity, transferring nitrogenous groups go/ molecular_function
pyridoxal phosphate binding go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC2526
(Mouseover regulator name to see its description)

BC2526 is regulated by 21 influences and regulates 15 modules.
Regulators for BC2526 (21)
Regulator Module Operator
BC0099 428 tf
BC0975 428 tf
BC1363 428 tf
BC2122 428 tf
BC2218 428 tf
BC2386 428 tf
BC2526 428 tf
BC2742 428 tf
BC3175 428 tf
BC5175 428 tf
BC0518 30 tf
BC1253 30 tf
BC2362 30 tf
BC2526 30 tf
BC2904 30 tf
BC3449 30 tf
BC3700 30 tf
BC4211 30 tf
BC4314 30 tf
BC4661 30 tf
BC4960 30 tf
Regulated by BC2526 (15)
Module Residual Genes
9 0.56 33
30 0.54 32
141 0.58 40
154 0.48 20
238 0.51 28
279 0.50 31
308 0.50 35
316 0.49 29
341 0.48 35
375 0.47 24
410 0.38 25
428 0.49 28
453 0.54 32
462 0.43 30
509 0.44 25
Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3982 3.40e+02 AA.GgaGgaGaGtg
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3983 2.50e+04 GGTcCcCaTCG
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4766 5.50e-07 aataaaaGgAG
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4767 4.70e+03 GgacGgGaga
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC2526

BC2526 is enriched for 7 functions in 3 categories.
Module neighborhood information for BC2526

BC2526 has total of 59 gene neighbors in modules 30, 428
Gene neighbors (59)
Gene Common Name Description Module membership
BC0171 BC0171 Chitooligosaccharide deacetylase (NCBI ptt file) 158, 428
BC0399 BC0399 Oxidoreductase (NCBI ptt file) 30, 85
BC0629 BC0629 Arginine/ornithine antiporter (NCBI ptt file) 134, 428
BC1047 BC1047 Protease production regulatory protein hpr (NCBI ptt file) 30, 199
BC1065 BC1065 hypothetical Membrane Spanning Protein (NCBI ptt file) 30, 453
BC1124 BC1124 Methyl-accepting chemotaxis protein (NCBI ptt file) 428, 489
BC1254 BC1254 hypothetical protein (NCBI ptt file) 9, 428
BC1363 BC1363 Leucine-responsive regulatory protein (NCBI ptt file) 204, 428
BC1577 BC1577 hypothetical protein (NCBI ptt file) 428, 481
BC1625 BC1625 Chemotaxis motA protein (NCBI ptt file) 30, 199
BC1626 BC1626 Chemotaxis motB protein (NCBI ptt file) 30, 199
BC1654 BC1654 Chemotaxis protein cheV (NCBI ptt file) 157, 428
BC1656 BC1656 Flagellin (NCBI ptt file) 30, 85
BC1676 BC1676 hypothetical protein (NCBI ptt file) 312, 428
BC1677 BC1677 Dienelactone hydrolase family (NCBI ptt file) 141, 428
BC1708 BC1708 hypothetical protein (NCBI ptt file) 30, 130
BC1723 BC1723 Prolipoprotein diacylglyceryl transferase (NCBI ptt file) 30, 250
BC1752 BC1752 Phosphohydrolase (MutT/nudix family protein) (NCBI ptt file) 214, 428
BC1758 BC1758 hypothetical Membrane Spanning Protein (NCBI ptt file) 30, 147
BC1767 BC1767 Sodium-dependent serine transporter (NCBI ptt file) 412, 428
BC2059 BC2059 Phosphoglycerate mutase (NCBI ptt file) 62, 428
BC2060 BC2060 hydrolase (HAD superfamily) (NCBI ptt file) 62, 428
BC2061 BC2061 Multidrug resistance protein B (NCBI ptt file) 256, 428
BC2080 BC2080 hypothetical Membrane Associated Protein (NCBI ptt file) 30, 502
BC2081 BC2081 DNA segregation ATPase and related proteins (FtsK/SpoIIIE family) (NCBI ptt file) 30, 502
BC2085 BC2085 hypothetical protein (NCBI ptt file) 30, 502
BC2362 BC2362 Transcriptional regulators, LysR family (NCBI ptt file) 30, 85
BC2526 BC2526 Transcriptional regulator, GntR family (NCBI ptt file) 30, 428
BC2699 BC2699 None 139, 428
BC2876 BC2876 Acetyltransferase (NCBI ptt file) 30, 364
BC2901 BC2901 ABC transporter permease protein (NCBI ptt file) 30, 204
BC2904 BC2904 Transcriptional regulator, GntR family (NCBI ptt file) 30, 60
BC3113 BC3113 Two-component response regulator ycbB (NCBI ptt file) 30, 199
BC3121 BC3121 5'-nucleotidase (NCBI ptt file) 214, 428
BC3146 BC3146 Peptidoglycan N-acetylglucosamine deacetylase (NCBI ptt file) 9, 428
BC3175 BC3175 Leucine-responsive regulatory protein (NCBI ptt file) 364, 428
BC3210 BC3210 hypothetical Cytosolic Protein (NCBI ptt file) 312, 428
BC3214 BC3214 hypothetical protein (NCBI ptt file) 30, 489
BC3215 BC3215 hypothetical protein (NCBI ptt file) 30, 253
BC3261 BC3261 hypothetical protein (NCBI ptt file) 30, 279
BC3446 BC3446 hypothetical protein (NCBI ptt file) 428, 453
BC3506 BC3506 Ribosomal-protein-alanine acetyltransferase (NCBI ptt file) 246, 428
BC3507 BC3507 hypothetical protein (NCBI ptt file) 428, 481
BC3510 BC3510 hypothetical protein (NCBI ptt file) 30, 291
BC3618 BC3618 Peptidoglycan N-acetylglucosamine deacetylase (NCBI ptt file) 30, 517
BC3639 BC3639 hypothetical Membrane Spanning Protein (NCBI ptt file) 214, 428
BC3694 BC3694 N-acetylmuramoyl-L-alanine amidase (NCBI ptt file) 30, 279
BC3695 BC3695 holin (NCBI ptt file) 30, 279
BC3698 BC3698 Cell wall endopeptidase, family M23/M37 (NCBI ptt file) 30, 279
BC3699 BC3699 Antigen (NCBI ptt file) 30, 279
BC3700 BC3700 Phage protein (NCBI ptt file) 30, 197
BC4216 BC4216 hypothetical protein (NCBI ptt file) 341, 428
BC4352 BC4352 Phenylalanine-4-hydroxylase (NCBI ptt file) 158, 428
BC4512 BC4512 Chemotaxis motB protein (NCBI ptt file) 30, 158
BC4619 BC4619 hypothetical protein (NCBI ptt file) 30, 316
BC4661 BC4661 Acetoin utilization acuB protein (NCBI ptt file) 30, 516
BC4812 BC4812 Cell surface protein (NCBI ptt file) 158, 428
BC4960 BC4960 Transcriptional regulator, DeoR family (NCBI ptt file) 30, 334
BC5428 BC5428 hypothetical protein (NCBI ptt file) 341, 428
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC2526
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend