Organism : Bacillus cereus ATCC14579 | Module List :
BC2779

Acetoin dehydrogenase E1 component alpha-subunit (NCBI ptt file)

CircVis
Functional Annotations (11)
Function System
Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit cog/ cog
pyruvate dehydrogenase (acetyl-transferring) activity go/ molecular_function
metabolic process go/ biological_process
Glycolysis / Gluconeogenesis kegg/ kegg pathway
Citrate cycle (TCA cycle) kegg/ kegg pathway
Valine leucine and isoleucine biosynthesis kegg/ kegg pathway
Pyruvate metabolism kegg/ kegg pathway
Butanoate metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC2779
(Mouseover regulator name to see its description)

BC2779 is regulated by 20 influences and regulates 0 modules.
Regulators for BC2779 (20)
Regulator Module Operator
BC1363 196 tf
BC2469 196 tf
BC2517 196 tf
BC2760 196 tf
BC2964 196 tf
BC3903 196 tf
BC4930 196 tf
BC5282 196 tf
BC0477 289 tf
BC1033 289 tf
BC1531 289 tf
BC1841 289 tf
BC2410 289 tf
BC2469 289 tf
BC2680 289 tf
BC2964 289 tf
BC3332 289 tf
BC3903 289 tf
BC4930 289 tf
BC5411 289 tf

Warning: BC2779 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4308 2.70e+00 g.aGGG.TGtA
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4309 1.40e+04 GccGGTaTGcC
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4494 6.50e-04 aaaaAgGAgaG
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4495 2.80e+04 GCACcG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC2779

BC2779 is enriched for 11 functions in 3 categories.
Module neighborhood information for BC2779

BC2779 has total of 29 gene neighbors in modules 196, 289
Gene neighbors (29)
Gene Common Name Description Module membership
BC0311 BC0311 hypothetical protein (NCBI ptt file) 84, 289
BC0401 BC0401 Cystine transport system permease protein (NCBI ptt file) 289, 339
BC0402 BC0402 Cystine-binding protein (NCBI ptt file) 289, 340
BC0969 BC0969 hypothetical protein (NCBI ptt file) 289, 469
BC1321 BC1321 hypothetical protein (NCBI ptt file) 115, 289
BC1608 BC1608 hypothetical Membrane Spanning Protein (NCBI ptt file) 289, 459
BC2316 BC2316 Thermitase (NCBI ptt file) 289, 459
BC2477 BC2477 hypothetical protein (NCBI ptt file) 196, 272
BC2522 BC2522 putative protein kinase (NCBI ptt file) 289, 521
BC2613 BC2613 Cytochrome P450 (NCBI ptt file) 54, 196
BC2681 BC2681 Transporter, Drug/Metabolite Exporter family (NCBI ptt file) 206, 289
BC2739 BC2739 Fosfomycin resistance protein (NCBI ptt file) 17, 289
BC2778 BC2778 Acetoin dehydrogenase E1 component beta-subunit (NCBI ptt file) 196, 289
BC2779 BC2779 Acetoin dehydrogenase E1 component alpha-subunit (NCBI ptt file) 196, 289
BC2795 BC2795 Ferredoxin (NCBI ptt file) 289, 521
BC2820 BC2820 Transposase (NCBI ptt file) 21, 196
BC2845 BC2845 hypothetical protein (NCBI ptt file) 17, 289
BC2966 BC2966 Polyketide synthase curC (NCBI ptt file) 115, 196
BC3001 BC3001 Glycosyltransferase involved in cell wall biogenesis (NCBI ptt file) 289, 378
BC3098 BC3098 Spore germination protein QB (NCBI ptt file) 289, 378
BC3179 BC3179 hypothetical protein (NCBI ptt file) 102, 196
BC3222 BC3222 ABC transporter ATP-binding protein (NCBI ptt file) 17, 196
BC3319 BC3319 hypothetical protein (NCBI ptt file) 289, 489
BC3359 BC3359 CDP-glucose 4,6-dehydratase (NCBI ptt file) 289, 463
BC3381 BC3381 hypothetical protein (NCBI ptt file) 196, 464
BC3395 BC3395 hypothetical protein (NCBI ptt file) 59, 196
BC3725 BC3725 Exochitinase (NCBI ptt file) 272, 289
BC3992 BC3992 hypothetical protein (NCBI ptt file) 289, 463
BC5151 BC5151 hypothetical Membrane Associated Protein (NCBI ptt file) 102, 196
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC2779
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend