Organism : Bacillus subtilis | Module List :
BSU05870 gmuF

phosphohexomutase; cupin family (RefSeq)

CircVis
Functional Annotations (9)
Function System
Phosphomannose isomerase cog/ cog
mannose-6-phosphate isomerase activity go/ molecular_function
carbohydrate metabolic process go/ biological_process
zinc ion binding go/ molecular_function
Fructose and mannose metabolism kegg/ kegg pathway
Amino sugar and nucleotide sugar metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
manA tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU05870
(Mouseover regulator name to see its description)

BSU05870 is regulated by 17 influences and regulates 0 modules.
Regulators for BSU05870 gmuF (17)
Regulator Module Operator
BSU03560 71 tf
BSU05850 71 tf
BSU09480 71 tf
BSU13760 71 tf
BSU15690 71 tf
BSU19090 71 tf
BSU24320 71 tf
BSU26320 71 tf
BSU33650 71 tf
BSU34180 71 tf
BSU36160 71 tf
BSU38450 71 tf
BSU02000 143 tf
BSU03890 143 tf
BSU05850 143 tf
BSU06960 143 tf
BSU07010 143 tf

Warning: BSU05870 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5098 5.90e-02 gagCcCgTcCC
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5099 8.80e+00 CcGGTacAAAaCAGGgGGAgAaG
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5236 6.60e-01 CcCCcCtttaattaaAgcGCTTaC
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5237 5.90e+02 cctgTTatCCcTT
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU05870

BSU05870 is enriched for 9 functions in 3 categories.
Enrichment Table (9)
Function System
Phosphomannose isomerase cog/ cog
mannose-6-phosphate isomerase activity go/ molecular_function
carbohydrate metabolic process go/ biological_process
zinc ion binding go/ molecular_function
Fructose and mannose metabolism kegg/ kegg pathway
Amino sugar and nucleotide sugar metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
manA tigr/ tigrfam
Module neighborhood information for BSU05870

BSU05870 has total of 41 gene neighbors in modules 71, 143
Gene neighbors (41)
Gene Common Name Description Module membership
BSU02410 mmuM homocysteine methyltransferase (RefSeq) 71, 226
BSU03530 ycxA putative permease (RefSeq) 71, 168
BSU03550 ycxC putative permease (RefSeq) 4, 71
BSU03560 ycxD putative PLP-dependent transcriptional regulator (RefSeq) 71, 318
BSU03740 yclI putative transporter (RefSeq) 71, 180
BSU05810 gmuB oligo-α-mannoside phosphotransferase system enzyme IIB (RefSeq) 10, 143
BSU05820 gmuA oligo-α-mannoside phosphotransferase system enzyme IIA (RefSeq) 10, 143
BSU05830 gmuC oligo-alpha-mannoside phosphotransferase system enzyme IIC (RefSeq) 10, 143
BSU05840 gmuD mannoside-phospho-beta-d-glucosidase (RefSeq) 10, 143
BSU05850 gmuR transcriptional regulator (GntR family) (RefSeq) 71, 143
BSU05860 gmuE putative carbohydrate kinase (RefSeq) 71, 143
BSU05870 gmuF phosphohexomutase; cupin family (RefSeq) 71, 143
BSU05880 gmuG exported mannan endo-1,4-beta-mannosidase (RefSeq) 10, 143
BSU06970 yesO pectin degradation byproducts-binding lipoprotein (RefSeq) 143, 360
BSU06980 yesP rhamnogalacturonan permease (RefSeq) 143, 360
BSU07010 yesS transcriptional regulator (AraC/XylS family) (RefSeq) 143, 372
BSU07020 rhgT rhamnogalacturonan acetylesterase (RefSeq) 143, 360
BSU07030 yesU hypothetical protein (RefSeq) 143, 372
BSU07070 yesY rhamnogalacturonan acetylesterase (RefSeq) 143, 372
BSU07080 yesZ beta-galacturonidase (RefSeq) 143, 372
BSU07090 yetA putative enzyme (RefSeq) 143, 360
BSU07100 lplA lipoprotein (RefSeq) 143, 372
BSU07120 lplC putative ABC transporter (permease) (RefSeq) 143, 360
BSU10450 yhjB putative Na+/metabolite cotransporter (RefSeq) 71, 311
BSU11080 yitQ hypothetical protein (RefSeq) 71, 341
BSU11090 yitR hypothetical protein (RefSeq) 71, 161
BSU12380 uxaB altronate oxidoreductase (RefSeq) 71, 318
BSU24910 yqgM putative glycosyltransferase (RefSeq) 71, 96
BSU24920 yqgL hypothetical protein (RefSeq) 71, 96
BSU26490 yrkJ putative integral inner membrane protein (RefSeq) 44, 71
BSU26500 yrkI hypothetical protein (RefSeq) 44, 71
BSU26510 yrkH putative hydrolase (RefSeq) 44, 71
BSU26530 yrkF putative rhodanese-related sulfur transferase (RefSeq) 44, 71
BSU26540 yrkE hypothetical protein (RefSeq) 71, 270
BSU30380 bceA bacitracin ABC efflux transporter (ATP-binding protein) (RefSeq) 71, 406
BSU30390 bceS two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA] (RefSeq) 71, 171
BSU30400 bceR two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB] (RefSeq) 71, 171
BSU32210 yuzD putative sulfur oxido-reduction management enzyme (RefSeq) 71, 171
BSU33650 yvzC putative transcriptional regulator (RefSeq) 49, 71
BSU38460 tyrZ tyrosyl-tRNA synthetase (RefSeq) 71, 285
BSU38480 ywaC (p)ppGpp synthetase (RefSeq) 71, 94
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU05870
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend