Organism : Bacillus subtilis | Module List :
BSU31550 yufO

putative carbohydrate ABC transporter (ATP-binding protein) (RefSeq)

CircVis
Functional Annotations (3)
Function System
ABC-type uncharacterized transport systems, ATPase components cog/ cog
ATP binding go/ molecular_function
monosaccharide-transporting ATPase activity go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU31550
(Mouseover regulator name to see its description)

BSU31550 is regulated by 13 influences and regulates 0 modules.
Regulators for BSU31550 yufO (13)
Regulator Module Operator
BSU19070 344 tf
BSU25760 344 tf
BSU32420 344 tf
BSU34480 344 tf
BSU37080 344 tf
BSU02550 219 tf
BSU06140 219 tf
BSU06540 219 tf
BSU26220 219 tf
BSU27080 219 tf
BSU34180 219 tf
BSU36600 219 tf
BSU40800 219 tf

Warning: BSU31550 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5382 6.60e+02 cTGGctGGa.agg.tG
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5383 5.70e+03 tgagggaGGAG
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5622 1.00e+03 CCCGGC
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5623 1.90e+03 GTGTGAAcCGG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU31550

BSU31550 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
ABC-type uncharacterized transport systems, ATPase components cog/ cog
ATP binding go/ molecular_function
monosaccharide-transporting ATPase activity go/ molecular_function
Module neighborhood information for BSU31550

BSU31550 has total of 26 gene neighbors in modules 219, 344
Gene neighbors (26)
Gene Common Name Description Module membership
BSU02120 ybeC putative H+/amino acid transporter (RefSeq) 219, 255
BSU02390 ybgE branched-chain amino acid aminotransferase (RefSeq) 344, 393
BSU02550 ycbL two-component response regulator [YcbM] (RefSeq) 168, 219
BSU02560 ycbM two-component sensor histidine kinase [YcbL] (RefSeq) 219, 301
BSU02770 yccK putative ion channel associated enzyme (RefSeq) 219, 350
BSU04780 ydcI putative RNA helicase (RefSeq) 219, 301
BSU07860 yfkL efflux transporter (RefSeq) 49, 219
BSU11000 yitI putative N-acetyltransferase (RefSeq) 64, 219
BSU13530 kinE two-component sensor histidine kinase (RefSeq) 219, 350
BSU14420 ykoA hypothetical protein (RefSeq) 219, 258
BSU14490 kinC two-component sensor histidine kinase (RefSeq) 173, 219
BSU17520 ynaD putative N-acetyltransferase (RefSeq) 219, 411
BSU18470 proJ gamma-glutamyl kinase (RefSeq) 202, 344
BSU18480 proH pyrroline-5-carboxylate reductase (RefSeq) 202, 344
BSU21750 scuA assembly factor BSco of the Cu(A) site of cytochrome c oxidase (RefSeq) 157, 219
BSU24610 sinR transcriptional regulator for post-exponential-phase response (RefSeq) 219, 404
BSU27080 levR transcriptional regulator (NifA/NtrC family) (RefSeq) 219, 231
BSU28430 sdhB succinate dehydrogenase iron-sulfur subunit (RefSeq) 219, 389
BSU31550 yufO putative carbohydrate ABC transporter (ATP-binding protein) (RefSeq) 219, 344
BSU31560 yufP putative permease of ABC transporter (RefSeq) 344, 406
BSU31570 yufQ putative permease of ABC transporter (RefSeq) 219, 344
BSU32520 pucG putative ureidoglycolate lyase (ureidoglycolase) (RefSeq) 219, 318
BSU33360 yvgJ putative exported enzyme and transporter (RefSeq) 219, 255
BSU33770 spbC killing factor SdpC (RefSeq) 162, 344
BSU40770 tetB multifunctional tetracycline-metal/H+ antiporter and Na+(K+)/H+ antiporter (RefSeq) 219, 334
BSU40780 tetL tetracycline resistance leader peptide (RefSeq) 219, 334
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU31550
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend