Organism : Bacillus subtilis | Module List :
BSU32070 yuiC

hypothetical protein (RefSeq)

CircVis
Functional Annotations (4)
Function System
Uncharacterized protein conserved in bacteria cog/ cog
hydrolase activity, hydrolyzing O-glycosyl compounds go/ molecular_function
peptidoglycan turnover go/ biological_process
outer membrane go/ cellular_component
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU32070
(Mouseover regulator name to see its description)

BSU32070 is regulated by 13 influences and regulates 0 modules.
Regulators for BSU32070 yuiC (13)
Regulator Module Operator
BSU05060 291 tf
BSU25100 291 tf
BSU33740 291 tf
BSU38310 291 tf
BSU04730 307 tf
BSU08300 307 tf
BSU12560 307 tf
BSU18760 307 tf
BSU26320 307 tf
BSU26340 307 tf
BSU34220 307 tf
BSU38070 307 tf
BSU40990 307 tf

Warning: BSU32070 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5520 3.20e-10 gaAAAaa.AGAttatgAAcAaGA
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5521 1.40e-04 ATGggCctCCTTTTTtaTgAggTA
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5552 1.70e+01 aAGGaG
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5553 1.10e+05 GCGcGG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU32070

BSU32070 is enriched for 4 functions in 3 categories.
Enrichment Table (4)
Function System
Uncharacterized protein conserved in bacteria cog/ cog
hydrolase activity, hydrolyzing O-glycosyl compounds go/ molecular_function
peptidoglycan turnover go/ biological_process
outer membrane go/ cellular_component
Module neighborhood information for BSU32070

BSU32070 has total of 50 gene neighbors in modules 291, 307
Gene neighbors (50)
Gene Common Name Description Module membership
BSU02030 ybdM putative protein kinase (RefSeq) 222, 291
BSU02710 yczC putative integral inner membrane protein (RefSeq) 96, 307
BSU03090 ycgF putative aminoacid export permease (RefSeq) 291, 402
BSU03100 ycgG hypothetical protein (RefSeq) 216, 291
BSU03340 yciA putative GTP cyclohydrolase (RefSeq) 307, 406
BSU03360 yciC putative metallochaperone with NTPase activity (RefSeq) 163, 291
BSU04110 lipC lysophopholipase (RefSeq) 11, 307
BSU05240 ydeL putative PLP-dependent transcriptional regulator (RefSeq) 115, 291
BSU06870 yesE hypothetical protein (RefSeq) 307, 361
BSU08230 catD catechol-2,3-dioxygenase membrane subunit (RefSeq) 178, 307
BSU08240 catE catechol-2,3-dioxygenase subunit (RefSeq) 238, 307
BSU08290 yfiJ two-component sensor histidine kinase [YfiK] (RefSeq) 132, 307
BSU08300 yfiK two-component response regulator [YfiJ] (RefSeq) 48, 307
BSU10170 fabHB 3-oxoacyl-(acyl carrier protein) synthase III (RefSeq) 307, 411
BSU11040 yitM hypothetical protein (RefSeq) 217, 307
BSU11320 yjzB hypothetical protein (RefSeq) 307, 411
BSU12070 yjdJ hypothetical protein (RefSeq) 166, 291
BSU12890 ykcC putative glycosyltransferase (RefSeq) 130, 291
BSU13790 ykvQ putative sporulation-specific glycosylase (RefSeq) 44, 291
BSU18920 phrK secreted regulator of the activity of phosphatase RapK (RefSeq) 239, 291
BSU19120 czrA transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressors family) (RefSeq) 78, 291
BSU21310 yozP hypothetical protein; phage SPbeta (RefSeq) 174, 307
BSU21530 yolB conserved hypothetical protein; phage SPbeta (RefSeq) 298, 307
BSU21540 yolA exported protein of unknown function; phage SPbeta (RefSeq) 298, 307
BSU23740 yqjU hypothetical protein (RefSeq) 36, 291
BSU23940 yqjB hypothetical protein (RefSeq) 291, 406
BSU25710 cwlH N-acetylmuramoyl-L-alanine amidase (RefSeq) 291, 406
BSU25720 yqeD hypothetical protein (RefSeq) 40, 291
BSU26160 yqbC conserved hypothetical protein; skin element (RefSeq) 145, 291
BSU26740 cypA cytochrome P450 (RefSeq) 280, 307
BSU30350 yttB putative efflux transporter (RefSeq) 51, 291
BSU32020 yuiH putative sulfite oxidase (RefSeq) 96, 291
BSU32030 bioYB putative biotin transporter (RefSeq) 177, 291
BSU32070 yuiC hypothetical protein (RefSeq) 291, 307
BSU32650 yurS hypothetical protein (RefSeq) 280, 307
BSU34000 cyeB cysteine and O-acetylserine efflux permease (RefSeq) 96, 307
BSU35280 yvjA putative integral inner membrane protein (RefSeq) 307, 411
BSU35770 tagC putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis) (RefSeq) 239, 307
BSU36340 ywpE putative sortase (RefSeq) 291, 318
BSU36480 ywoD putative efflux transporter (RefSeq) 50, 307
BSU36490 ywoC putative hydrolase (RefSeq) 50, 307
BSU36500 ywoB putative integral inner membrane protein (RefSeq) 130, 307
BSU36790 ywmA hypothetical protein (RefSeq) 51, 291
BSU38250 ywbO putative sulfur oxido-reductase (RefSeq) 96, 307
BSU38310 ywbI putative transcriptional regulator (LysR family) (RefSeq) 291, 409
BSU38330 lrgB anti-holin factor controlling activity of murein hydrolases (RefSeq) 291, 409
BSU38410 sacX negative regulator of SacY (RefSeq) 98, 291
BSU39830 yxcA hypothetical protein (RefSeq) 263, 291
BSU39850 yxbF putative transcriptional regulator (RefSeq) 213, 291
BSU40980 yyaB putative integral inner membrane protein (RefSeq) 115, 291
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU32070
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend