Organism : Bacillus subtilis | Module List :
Regulation information for VIMSS39609(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 2 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Module neighborhood information for VIMSS39609
|Gene||Common Name||Description||Module membership|
|BSU03130||nadE||NAD synthetase (RefSeq)||29, 169|
|BSU04410||ydbB||putative enzyme ; cupin family (RefSeq)||29, 353|
|BSU04420||ydbC||hypothetical protein (RefSeq)||29, 353|
|BSU05100||yddT||hypothetical protein (RefSeq)||29, 299|
|BSU10320||yhfP||putative oxidoreductase (RefSeq)||29, 252|
|BSU13010||ykgB||putative 6-phosphogluconolactonase (RefSeq)||29, 113|
|BSU16330||cheY||regulator of chemotaxis and motility (RefSeq)||2, 254|
|BSU16340||fliZ||flagella biosynthesis protein FliZ (RefSeq)||2, 382|
|BSU16350||fliP||flagellar biosynthesis protein FliP (RefSeq)||2, 254|
|BSU16360||fliQ||flagellar biosynthesis protein FliQ (RefSeq)||2, 45|
|BSU16370||fliR||flagellar biosynthesis protein FliR (RefSeq)||2, 382|
|BSU16380||flhB||flagellar biosynthesis protein FlhB (RefSeq)||2, 45|
|BSU16390||flhA||flagellar biosynthesis protein FlhA (RefSeq)||2, 45|
|BSU16400||flhF||flagellar biosynthesis regulator FlhF (RefSeq)||2, 45|
|BSU16410||ylxH||essential component of the flagellar assembly machinery (RefSeq)||2, 45|
|BSU16420||cheB||chemotaxis-specific methylesterase (RefSeq)||2, 45|
|BSU16430||cheA||chemotactic two-component sensor histidine kinase (RefSeq)||2, 45|
|BSU16440||cheW||modulation of CheA activity in response to attractants (chemotaxis) (RefSeq)||2, 45|
|BSU16450||cheC||signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs) (RefSeq)||2, 235|
|BSU16460||cheD||sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR (RefSeq)||2, 45|
|BSU16470||sigD||RNA polymerase sigma factor SigD (RefSeq)||2, 382|
|BSU16480||ylxL||coupling factor for flagellin transcription and translation (RefSeq)||2, 254|
|BSU21320||yomL||conserved hypothetical protein; phage SPbeta (RefSeq)||29, 299|
|BSU24470||yqhS||3-dehydroquinate dehydratase (RefSeq)||29, 256|
|BSU28340||ysnF||putative stress response protein (RefSeq)||29, 299|
|BSU28410||gerE||transcriptional regulator (RefSeq)||29, 248|
|BSU30650||dps||DNA-protecting protein, ferritin (RefSeq)||29, 320|
|BSU32100||yumB||putative NAD-disulfide oxidoreductase (RefSeq)||29, 391|
|BSU32450||pucL||urate oxidase with peroxide reductase N-terminal domain (RefSeq)||29, 231|
|BSU32500||pucB||enzyme for molybdopterin cofactor synthesis required for xanthine dehydrogenase (RefSeq)||29, 231|
|BSU33620||yvaK||carboxylesterase (RefSeq)||29, 149|
|BSU34680||yvcT||putative 2-hydroxyacid dehydrogenase (RefSeq)||29, 169|
|BSU35620||lytC||N-acetylmuramoyl-L-alanine amidase (major autolysin) (RefSeq)||2, 254|
|BSU35630||lytB||modifier protein of major autolysin LytC (RefSeq)||2, 254|
|BSU35970||ywsB||hypothetical protein (RefSeq)||29, 149|
|BSU37300||ywiC||putative integral inner membrane protein (RefSeq)||29, 238|
|BSU37940||ywdJ||putative purine/pyrimidine permease (RefSeq)||29, 243|
|BSU37950||ywdI||hypothetical protein (RefSeq)||29, 243|
|BSU38190||galT||galactose-1-phosphate uridylyltransferase (RefSeq)||29, 149|
|BSU38200||galK||galactokinase (RefSeq)||29, 183|
|BSU38620||yxlJ||3-methyladenine DNA glycosylase (RefSeq)||29, 59|
|BSU38980||scoB||succinyl CoA:3-oxoacid CoA-transferase (subunit B) (RefSeq)||29, 231|
|BSU39560||yxeG||putative integral inner membrane protein (RefSeq)||29, 233|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
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