Module Functions 1 "Glutamate synthase domain 2:Mg-dependent DNase:Short-chain dehydrogenases of various substrate specificities:Acetyltransferases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:ABC-type Fe3+-siderophore transport system, permease component:Thiamine monophosphate kinase:Uracil DNA glycosylase:Alanine racemase:UDP-N-acetylmuramate dehydrogenase:Predicted GTPases:Predicted glycosyltransferases:Transcriptional regulator:Predicted transcriptional regulator:Large-conductance mechanosensitive channel:Uncharacterized conserved protein:Permeases:Predicted SAM-dependent methyltransferase:D-serine dehydratase:Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain:Superfamily I DNA and RNA helicases:Predicted membrane protein:Capsular polysaccharide biosynthesis protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:D-Alanine metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Thiamine metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Base excision repair:Nucleotide excision repair:Mismatch repair:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00010:murB:mscL:alr:ung:PduO_Nterm:rrf2_super:GOGAT_sm_gam:thiL:rimI:D_Ser_am_lyase:GTPase_YlqF:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Amino acids and amines:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Other:Ribosomal proteins: synthesis and modification:Cellular processes:Adaptations to atypical conditions:Unknown function:Enzymes of unknown specificity:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Thiamine:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 2 "ATPases involved in chromosome partitioning:Chemotaxis protein histidine kinase and related kinases:FOG: CheY-like receiver:Chemotaxis signal transduction protein:DNA-directed RNA polymerase specialized sigma subunit:Flagellar biosynthesis pathway, component FlhA:Flagellar biosynthesis pathway, component FliP:Flagellar biosynthesis pathway, component FlhB:Flagellar GTP-binding protein:Flagellar biosynthesis pathway, component FliR:Chemotaxis protein CheC, inhibitor of MCP methylation:Chemotaxis protein; stimulates methylation of MCP proteins:Flagellar biosynthesis pathway, component FliQ:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Putative cell wall-binding domain:Sporulation protein and related proteins:Flagellar biogenesis protein:Cell cycle control, cell division, chromosome partitioning:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Two-component system:Bacterial chemotaxis:Flagellar assembly:RNA polymerase:Signal transduction mechanisms:flhB:fliP:FlhA:fliR:fliQ:FliA_WhiG:SpoIID_LytB:FlhF:Intracellular trafficking, secretion, and vesicular transport:Cellular Processes:Signal Transduction:Environmental Information Processing:Cellular processes and signaling:Transcription:Information storage and processing:General:Unknown function:Chemotaxis and motility:Cellular processes:Genetic Information Processing:Cell Motility" 3 "Ribosomal protein S12:Ribosomal protein S9:Ribosomal protein L27:Ribosomal protein S18:Ribosomal protein L31:Ribosomal protein L21:Ribosomal protein L32:Ribosomal protein L19:Ribosomal protein S6:Single-stranded DNA-binding protein:Predicted RNA binding protein (contains ribosomal protein S1 domain):Ribosomal protein HS6-type (S12/L30/L7a):Phosphate transport regulator (distant homolog of PhoU):Predicted metal-binding, possibly nucleic acid-binding protein:Predicted ribosomal protein:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Inorganic ion transport and metabolism:Ribosome:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:L21:L27:L31:S18:S6:ssb:rpsL_bact:rplS_bact:rpmF_bact:DNA replication, recombination, and repair:DNA metabolism:Genetic Information Processing:Replication and Repair:Poorly characterized:Translation:Metabolism:Information storage and processing:Ribosomal proteins: synthesis and modification:Protein synthesis" 4 "Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Tryptophan synthase beta chain:Indole-3-glycerol phosphate synthase:Phosphoribosylanthranilate isomerase:Anthranilate/para-aminobenzoate synthases component I:Tryptophan synthase alpha chain:Anthranilate phosphoribosyltransferase:Aldo/keto reductases, related to diketogulonate reductase:Permeases of the drug/metabolite transporter (DMT) superfamily:ABC-type metal ion transport system, periplasmic component/surface adhesin:ABC-type Mn2+/Zn2+ transport systems, permease components:ABC-type Mn/Zn transport systems, ATPase component:Putative copper export protein:Transcriptional regulators of sugar metabolism:Disulfide bond formation protein DsbB:Protein-disulfide isomerase:Nucleoside permease:ABC-type proline/glycine betaine transport systems, periplasmic components:Arabinose efflux permease:ABC-type proline/glycine betaine transport system, ATPase component:ABC-type proline/glycine betaine transport system, permease component:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycine serine and threonine metabolism:Histidine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:Function unknown:trpA:trpB:trpE_most:nupC:hisC:proV:trpD:Amino acid biosynthesis:Nucleosides, purines and pyrimidines:Amino acids, peptides and amines:Transport and binding proteins:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Biosynthesis of Other Secondary Metabolites:Poorly characterized:Amino Acid Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Histidine family:Aromatic amino acid family" 5 "Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Cell wall-associated hydrolases (invasion-associated proteins):Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Flagellin and related hook-associated proteins:Carbon storage regulator (could also regulate swarming and quorum sensing):Uncharacterized protein conserved in bacteria:Beta- N-acetylglucosaminidase:Flagellar basal body rod protein:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Other glycan degradation:Two-component system:Bacterial chemotaxis:Flagellar assembly:Function unknown:Signal transduction mechanisms:csrA:GGDEF:FlgEFG_subfam:Cellular processes and signaling:Glycan Biosynthesis and Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Regulatory functions:RNA interactions:Signal transduction:Other:Metabolism:Metabolism:Poorly characterized" 6 "ATP phosphoribosyltransferase:Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase:Imidazoleglycerol-phosphate synthase:Glutamine amidotransferase:Imidazoleglycerol-phosphate dehydratase:Phosphoribosyl-AMP cyclohydrolase:Histidinol dehydrogenase:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Thiamine monophosphate synthase:Thiamine biosynthesis protein ThiC:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:ABC-type cobalt transport system, permease component CbiQ and related transporters:Glycine/D-amino acid oxidases (deaminating):Putative transcription activator:ATPase components of various ABC-type transport systems, contain duplicated ATPase:Uncharacterized enzyme of thiazole biosynthesis:Sulfur transfer protein involved in thiamine biosynthesis:ATP phosphoribosyltransferase involved in histidine biosynthesis:Predicted membrane protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Transcription:Inorganic ion transport and metabolism:Histidine metabolism:Thiamine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Sulfur relay system:General function prediction only:Function unknown:TIGR00007:hisD:hisG:HMP-P_kinase:thiC:hisZ_biosyn_reg:hisF:thiS:IMP_synth_hisH:thiamin_ThiO:histidine_hisI:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Thiamine:Amino Acid Metabolism:Information storage and processing:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Histidine family:Amino acid biosynthesis:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism:Folding Sorting and Degradation" 7 "GTPases - translation elongation factors:Lipoate-protein ligase A:Methionyl-tRNA synthetase:Ribonuclease HII:Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):RecA/RadA recombinase:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:Predicted RNA binding protein (contains ribosomal protein S1 domain):Cold shock proteins:Uncharacterized conserved protein:Phage shock protein A (IM30), suppresses sigma54-dependent transcription:Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB:Uncharacterized conserved protein (small basic protein):Uncharacterized protein conserved in bacteria:Predicted secreted protein:Uncharacterized protein conserved in bacteria:Site-specific recombinase XerD:Predicted glycosyltransferase:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Selenocompound metabolism:Aminoacyl-tRNA biosynthesis:Ribosome:DNA replication:Homologous recombination:Function unknown:Signal transduction mechanisms:S21p:efp:small_GTP:metG:flhB_rel:tigrfam_recA:recomb_XerD:YvyF:Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Translation:Replication and Repair:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Translation factors:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 8 "Peroxiredoxin:Proline dehydrogenase:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Permeases of the drug/metabolite transporter (DMT) superfamily:Predicted ATP-dependent protease:ABC-type multidrug transport system, ATPase component:AraC-type DNA-binding domain-containing proteins:Pectate lyase:O-Glycosyl hydrolase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Pentose and glucuronate interconversions:Arginine and proline metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:spore_lonB:Defense mechanisms:Amino Acid Metabolism:Information storage and processing:Carbohydrate Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Sporulation and germination:Cellular processes:Metabolism:Global" 9 "Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):DNA replication protein:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Putative phage replication protein RstA:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:RNA polymerase:sigma70-ECF:Transcription:Genetic Information Processing:Information storage and processing:Cellular processes and signaling" 10 "Ammonia permease:Glutamate synthase domain 2:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Zn-dependent protease with chaperone function:Predicted nucleoside-diphosphate-sugar epimerases:5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases:Phosphotransferase system cellobiose-specific component IIB:Phosphotransferase system cellobiose-specific component IIA:Phosphotransferase system cellobiose-specific component IIC:Beta-galactosidase:Glutaminase:Cytochrome P450:Transcriptional regulators:Sugar phosphate permease:Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase:Arabinose efflux permease:Zinc metalloprotease (elastase):Beta-mannanase:Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins:Predicted integral membrane protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Galactose metabolism:Fatty acid metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Bisphenol degradation:Cyanoamino acid metabolism:D-Glutamine and D-glutamate metabolism:Starch and sucrose metabolism:Polycyclic aromatic hydrocarbon degradation:Aminobenzoate degradation:Limonene and pinene degradation:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Phosphotransferase system (PTS):Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:cello_pts_IIC:amt:2A0114:LPXTG_anchor:trehalos_R_Bsub:Gln_ase:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Amino acids and amines:Carbohydrate Metabolism:Regulatory functions:DNA interactions:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Signal transduction:PTS:Cell envelope:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Energy metabolism:Metabolism:Global" 11 "Threonyl-tRNA synthetase:Acetyltransferases:Aspartokinases:Transcriptional regulator:Na+/proline symporter:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):ABC-type multidrug transport system, ATPase component:Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities:Transcriptional regulator:Predicted membrane protein/domain:Predicted transcriptional regulators:Predicted membrane-bound metal-dependent hydrolases:Predicted acyltransferase:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:AraC-type DNA-binding domain-containing proteins:Uncharacterized conserved protein:Lysophospholipase L1 and related esterases:Arabinose efflux permease:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Selenocompound metabolism:Nitrogen metabolism:Sulfur metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:thrS:asp_kinases:efflux_EmrB:sss:Defense mechanisms:Aspartate family:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Translation:Global:Metabolism:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Cations and iron carrying compounds:Other:Amino acid biosynthesis:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 12 "Energy production and conversion:7-keto-8-aminopelargonate synthetase and related enzymes:Gamma-glutamyltransferase:Rieske Fe-S protein:DNA-directed RNA polymerase specialized sigma subunit:Transcriptional regulator:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Anti-sigma regulatory factor (Ser/Thr protein kinase):Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Coenzyme transport and metabolism:Transcription:Oxidative phosphorylation:Glycine serine and threonine metabolism:Taurine and hypotaurine metabolism:Selenocompound metabolism:Cyanoamino acid metabolism:Glutathione metabolism:Arachidonic acid metabolism:Metabolic pathways:RNA polymerase:Function unknown:Signal transduction mechanisms:g_glut_trans:ant_ant_sig:bioF:spIIAB:spore_sigmaE:spore_II_GA:spore_sigF:Glutathione and analogs:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Transcription:Global:Metabolism:Regulatory functions:Protein interactions:Cellular processes:Sporulation and germination:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 13 "Energy production and conversion:6-phosphogluconate dehydrogenase:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Parvulin-like peptidyl-prolyl isomerase:ABC-type amino acid transport system, permease component:Cell division protein FtsI/penicillin-binding protein 2:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Branched-chain amino acid permeases:ABC-type polar amino acid transport system, ATPase component:Transcriptional regulator:Putative transcriptional regulator, homolog of Bvg accessory factor:Predicted periplasmic solute-binding protein:Predicted membrane protein/domain:Predicted transcriptional regulator:Cell division protein:Arabinose efflux permease:Predicted ATPase involved in cell division:Predicted periplasmic or secreted protein:Predicted membrane protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Oxidative phosphorylation:Glutathione metabolism:Thiamine metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Sulfur relay system:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00247:baf:efflux_EmrB:livcs:gnd:2A0121:HEQRo_perm_3TM:thia_yuaJ:FtsE:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Energy Metabolism:Cations and iron carrying compounds:Carbohydrate Metabolism:Other:Cellular processes:Cell division:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Amino acids, peptides and amines:Transport and binding proteins:Pentose phosphate pathway:Energy metabolism" 14 "Protein chain release factor A:Predicted choline kinase involved in LPS biosynthesis:FOG: CBS domain:Transcriptional regulator:Predicted transcriptional regulators:Multimeric flavodoxin WrbA:Formyltetrahydrofolate hydrolase:Predicted UDP-glucose 6-dehydrogenase:Na+/H+ antiporter NhaD and related arsenite permeases:Choline-glycine betaine transporter:Transcriptional regulator:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:1,4-dihydroxy-2-naphthoate octaprenyltransferase:Uncharacterized conserved protein:Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein:Transcriptional regulators:Dioxygenases related to 2-nitropropane dioxygenase:Sugar phosphate permease:Arabinose efflux permease:Methylase of polypeptide chain release factors:Uncharacterized conserved protein:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Function unknown:prfA:IMPACT_YIGZ:lytR_cpsA_psr:hemK_fam:PurU:efflux_Bcr_CflA:efflux_EmrB:menA:bcct:2a45:GMP_reduct_2:NDP-sugDHase:Other:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Purine ribonucleotide biosynthesis:Regulatory functions:Other:Protein synthesis:Translation factors:Protein fate:Protein modification and repair:Transport and binding proteins:Metabolism:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 15 "Aspartate oxidase:Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog):DNA-directed RNA polymerase, beta subunit/140 kD subunit:DNA-directed RNA polymerase, beta' subunit/160 kD subunit:Phosphoglycerate dehydrogenase and related dehydrogenases:Geranylgeranyl pyrophosphate synthase:Nicotinate-nucleotide pyrophosphorylase:Acetyl-CoA acetyltransferase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Quinolinate synthase:RNase P protein component:Non-ribosomal peptide synthetase modules and related proteins:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Uncharacterized conserved protein:Predicted membrane protein involved in D-alanine export:Predicted small molecule binding protein (contains 3H domain):ABC-type proline/glycine betaine transport systems, periplasmic components:Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein):ABC-type proline/glycine betaine transport system, ATPase component:ABC-type proline/glycine betaine transport system, permease component:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Fatty acid metabolism:Synthesis and degradation of ketone bodies:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Benzoate degradation:Tryptophan metabolism:D-Alanine metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Thiamine metabolism:Nicotinate and nicotinamide metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:RNA polymerase:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:nadC:gatB:rnpA:nadA:nadB:proV:PGDH:AA-adenyl-dom:AcCoA-C-Actrans:rpoB:rpoC_TIGR:GerC3_HepT:LTA_dltB:LTA_DltD:Amino acid biosynthesis:Serine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Pyridine nucleotides:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Transcription:Other:Fatty acid and phospholipid metabolism:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Translation:Transcription:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:DNA-dependent RNA polymerase:Carbohydrate Metabolism:RNA processing:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Amino acids, peptides and amines" 16 "Glucan phosphorylase:Molecular chaperone (small heat shock protein):Predicted permease:Predicted xylanase/chitin deacetylase:Membrane proteins related to metalloendopeptidases:D-alanyl-D-alanine carboxypeptidase:Uncharacterized conserved protein:Predicted ATPase related to phosphate starvation-inducible protein PhoH:Uncharacterized protein conserved in bacteria:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Starch and sucrose metabolism:General function prediction only:Function unknown:Signal transduction mechanisms:P_ylase:spore_ybaN_pdaB:spore_YyaC:spore_ylbJ:spore_ytvI:spore_yqfD:spore_YlmC_YmxH:Poorly characterized:Carbohydrate Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Cellular processes:Sporulation and germination:Cellular processes and signaling:Metabolism:Metabolism" 17 "Energy production and conversion:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit:Glycosidases:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:Predicted phosphatase/phosphohexomutase:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit:ABC-type sugar transport systems, permease components:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases:Trehalose and maltose hydrolases (possible phosphorylases):Transcriptional regulators:Maltose-binding periplasmic proteins/domains:ABC-type maltose transport systems, permease component:Predicted integral membrane protein:Carbohydrate transport and metabolism:Transcription:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Starch and sucrose metabolism:Pyruvate metabolism:Butanoate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Bacterial chemotaxis:Phosphotransferase system (PTS):General function prediction only:Function unknown:EIIB_glc:lipoamide_DH:HAD-SF-IA-v3:Poorly characterized:Carbohydrate Metabolism:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Unknown function:Enzymes of unknown specificity:Signal transduction:PTS:Information storage and processing:Metabolism:Metabolism" 18 "Intein/homing endonuclease:Uncharacterized protein conserved in bacteria:Replication, recombination and repair:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:Function unknown:intein_Cterm:Information storage and processing:Poorly characterized:Metabolism:Metabolism:Global:Nucleotide Metabolism" 19 "Energy production and conversion:Gamma-glutamyltransferase:Glycosyltransferase:Glycosyltransferases involved in cell wall biogenesis:Nitroreductase:Predicted UDP-glucose 6-dehydrogenase:Sugar (pentulose and hexulose) kinases:Co/Zn/Cd efflux system component:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Subtilisin-like serine proteases:Phage shock protein A (IM30), suppresses sigma54-dependent transcription:Predicted flavoprotein involved in K+ transport:Xylose isomerase:Uncharacterized conserved protein:Methylase involved in ubiquinone/menaquinone biosynthesis:Uncharacterized conserved protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Fructose and mannose metabolism:Ascorbate and aldarate metabolism:Taurine and hypotaurine metabolism:Selenocompound metabolism:Cyanoamino acid metabolism:Glutathione metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Arachidonic acid metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Phosphotransferase system (PTS):Function unknown:Signal transduction mechanisms:g_glut_trans:CDF:XylB:xylose_isom_A:NDP-sugDHase:Information storage and processing:Glutathione and analogs:Biosynthesis of cofactors, prosthetic groups, and carriers:Cations and iron carrying compounds:Transport and binding proteins:Sugars:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism of Other Amino Acids:Lipid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling" 20 "Predicted membrane protein:Glutathione peroxidase:Zn-dependent protease with chaperone function:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains):Uncharacterized conserved protein:GTPase subunit of restriction endonuclease:Predicted HD superfamily hydrolase:Transcriptional regulators:Predicted CoA-binding protein:Endoglucanase:Arginine degradation protein (predicted deacylase):Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glutathione metabolism:Starch and sucrose metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Arachidonic acid metabolism:Metabolic pathways:ABC transporters:Two-component system:General function prediction only:Function unknown:TIGR00023:nudix_YtkD:addA_Gpos:Defense mechanisms:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:DNA replication, recombination, and repair:DNA metabolism:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism of Other Amino Acids:Lipid Metabolism:Carbohydrate Metabolism" 21 "Molecular chaperone (small heat shock protein):Glycosyltransferase:Nucleoside-diphosphate-sugar epimerases:Adenylylsulfate kinase and related kinases:Predicted UDP-glucose 6-dehydrogenase:UDP-glucose pyrophosphorylase:ATP sulfurylase (sulfate adenylyltransferase):Putative homoserine kinase type II (protein kinase fold):Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Galactose metabolism:Ascorbate and aldarate metabolism:Purine metabolism:Selenocompound metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:sopT:apsK:spore_dpaB:spore_dpaA:spore_CotS:NDP-sugDHase:Poorly characterized:Central intermediary metabolism:Metabolism:Global:Metabolism of Other Amino Acids:Nucleotide Metabolism:Energy Metabolism:Metabolism:Sulfur metabolism:Carbohydrate Metabolism:Cellular processes:Sporulation and germination:Cellular processes and signaling:Metabolism" 22 "Energy production and conversion:Thymidine phosphorylase:Cytidine deaminase:Glycerol kinase:Glycerol-3-phosphate dehydrogenase:Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family):2-methylthioadenine synthetase:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB):GTPase:Transcriptional regulators of sugar metabolism:Phosphomannose isomerase:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Transcriptional regulators:S-adenosylmethionine decarboxylase:Transcriptional regulators:Na+/H+ antiporter:Transcriptional regulator, contains sigma factor-related N-terminal domain:Transcriptional antiterminator:Signal transduction histidine kinase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Fructose and mannose metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:General function prediction only:Signal transduction mechanisms:TIGR00089:manA:sensory_box:small_GTP:MIP:antiport_nhaC:glycerol_kin:cyt_deam_tetra:Y_phosphoryl:1-PFK:SAM_DCase_Bsu:integ_memb_HG:Other:Energy metabolism:Polyamine biosynthesis:Central intermediary metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Sugars:Carbohydrate Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Other:Salvage of nucleosides and nucleotides:Regulatory functions:Small molecule interactions:Transport and binding proteins:Unknown substrate:Cations and iron carrying compounds:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 23 "Energy production and conversion:Predicted hydrolases of the HAD superfamily:Transcriptional regulator:Glycerophosphoryl diester phosphodiesterase:Predicted permease:Enzyme related to GTP cyclohydrolase I:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Sortase and related acyltransferases:Amidases related to nicotinamidase:Transcriptional regulators:Predicted Rossmann fold nucleotide-binding protein:Uncharacterized protein conserved in bacteria:DNA segregation ATPase FtsK/SpoIIIE and related proteins:Predicted pyrophosphatase:Predicted transcriptional regulator:Acyl dehydratase:Transcriptional regulators:Uncharacterized conserved protein:Predicted membrane protein:Predicted membrane protein:Cell cycle control, cell division, chromosome partitioning:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Glycerophospholipid metabolism:Biosynthesis of siderophore group nonribosomal peptides:Biosynthesis of secondary metabolites:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Cof-subfamily:TIGR00730:QueF-II:Global:Signal Transduction:Environmental Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism:Lipid Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Enzymes of unknown specificity:Unknown function:Conserved:Hypothetical proteins:Metabolism" 24 "6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase:ABC-type proline/glycine betaine transport systems, ATPase components:ABC-type proline/glycine betaine transport systems, permease component:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Predicted transcriptional regulators:Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein):Transcriptional regulators:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:ABC transporters:Phosphotransferase system (PTS):Function unknown:nagB:EIIB_glc:proV:PTS:Carbohydrate Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Amino sugars:Transport and binding proteins:Amino acids, peptides and amines:Signal transduction:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 25 "(acyl-carrier-protein) S-malonyltransferase:ABC-type Fe3+-siderophore transport system, permease component:ABC-type Fe3+-hydroxamate transport system, periplasmic component:Predicted transcriptional regulators:Transcriptional regulators:Uncharacterized protein, involved in the regulation of septum location:Uncharacterized protein conserved in bacteria:Predicted hydrolase of the alpha/beta superfamily:Endoglucanase C-terminal domain/subunit and related proteins:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:ABC transporters:General function prediction only:Function unknown:fabD:Fatty acid and phospholipid metabolism:Membrane Transport:Environmental Information Processing:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis" 26 "Energy production and conversion:Carbonic anhydrase:Methylated DNA-protein cysteine methyltransferase:Selenocysteine lyase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Threonine dehydrogenase and related Zn-dependent dehydrogenases:Hydrolases of the alpha/beta superfamily:Hemolysins and related proteins containing CBS domains:Na+/H+-dicarboxylate symporters:D-mannonate dehydratase:Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases:Sec-independent protein secretion pathway components:Malate/L-lactate dehydrogenases:Uncharacterized distant relative of cell wall-associated hydrolases:UV damage repair endonuclease:Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Fructose and mannose metabolism:Galactose metabolism:Bisphenol degradation:Glycerolipid metabolism:Sphingolipid metabolism:Chloroalkane and chloroalkene degradation:Butanoate metabolism:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:ogt:uvde:uxuA:tatAE:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Protein and peptide secretion and trafficking:Protein fate:DNA replication, recombination, and repair:DNA metabolism:Sugars:Energy metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism" 27 "Phosphatidylglycerophosphatase A and related proteins:Lipid transport and metabolism:Metabolism" 28 "Energy production and conversion:Ornithine carbamoyltransferase:Phosphoglycerate dehydrogenase and related dehydrogenases:Dihydroxyacid dehydratase/phosphogluconate dehydratase:Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family:Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases:Anaerobic dehydrogenases, typically selenocysteine-containing:Fructose-2,6-bisphosphatase:Aspartate/tyrosine/aromatic aminotransferase:Carbamoylphosphate synthase large subunit (split gene in MJ):Carbamoylphosphate synthase small subunit:Acetylglutamate kinase:Na+/proline symporter:Methionine synthase II (cobalamin-independent):Cystathionine beta-lyases/cystathionine gamma-synthases:Methionine synthase I (cobalamin-dependent), methyltransferase domain:Sugar (pentulose and hexulose) kinases:Amidases related to nicotinamidase:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Ribulose 1,5-bisphosphate carboxylase, large subunit:Arabinose efflux permease:Uncharacterized conserved protein, possibly involved in methylthioadenosine recycling:Predicted kinase:Ornithine/acetylornithine aminotransferase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Glycolysis / Gluconeogenesis:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Selenocompound metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Nitrogen metabolism:Sulfur metabolism:Biosynthesis of siderophore group nonribosomal peptides:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:ilvD:salvage_mtnA:orni_carb_tr:argD:argB:2A0118:CPSaseIIsmall:CPSaseII_lrg:met_syn_B12ind:HAD-SF-IB:MTRK:salvage_mtnB:salvage_mtnW:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Pyrimidine ribonucleotide biosynthesis:Carbohydrate Metabolism:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aspartate family:Glutamate family:Pyruvate family:Information storage and processing:Metabolism:Poorly characterized:Purines, pyrimidines, nucleosides, and nucleotides:Sulfur metabolism:Central intermediary metabolism:Metabolism:Global:Metabolism:Metabolism of Terpenoids and Polyketides" 29 "Energy production and conversion:Galactokinase:NAD synthase:NADPH:quinone reductase and related Zn-dependent oxidoreductases:Mannose-6-phosphate isomerase:3-dehydroquinate dehydratase II:DNA-binding ferritin-like protein (oxidative damage protectant):Lactate dehydrogenase and related dehydrogenases:NADH dehydrogenase, FAD-containing subunit:Esterase/lipase:Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit:Uncharacterized MobA-related protein:3-methyladenine DNA glycosylase:Xanthine/uracil permeases:3-carboxymuconate cyclase:DNA-binding HTH domain-containing proteins:Uricase (urate oxidase):Uncharacterized protein conserved in bacteria:Galactose-1-phosphate uridyltransferase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Pentose phosphate pathway:Galactose metabolism:Synthesis and degradation of ketone bodies:Oxidative phosphorylation:Purine metabolism:Caffeine metabolism:Valine leucine and isoleucine degradation:Phenylalanine tyrosine and tryptophan biosynthesis:Amino sugar and nucleotide sugar metabolism:Butanoate metabolism:Nicotinate and nicotinamide metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:gal_kin:nadE:3mg:aroQ:galT_2:TIGR02271:pcaJ_scoB_fam:oxido_YhdH:UHCUDC:pucB:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Replication and Repair:Global:Metabolism:Energy metabolism:Sugars:DNA metabolism:DNA replication, recombination, and repair:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Information storage and processing:Metabolism:Metabolism" 30 "Energy production and conversion:Methionine aminopeptidase:Glutamine synthetase:Preprotein translocase subunit SecY:Ribonucleotide reductase, beta subunit:Ribonucleotide reductase, alpha subunit:Thiamine biosynthesis ATP pyrophosphatase:Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains:Zn-dependent protease with chaperone function:Predicted GTPase:ABC-type cobalt transport system, permease component CbiQ and related transporters:Small-conductance mechanosensitive channel:MoxR-like ATPases:Predicted transcriptional regulators:ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains):Transcription termination factor:Uncharacterized Fe-S protein:Protein involved in ribonucleotide reduction:Transcriptional regulators:Protein affecting phage T7 exclusion by the F plasmid:Predicted exonuclease:Predicted phosphoesterase (MutT family):Site-specific recombinase XerD:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Thiamine metabolism:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Two-component system:RNA degradation:Protein export:Bacterial secretion system:Sulfur relay system:General function prediction only:small_GTP:TIGR00276:nrdI:TIGR00342:met_pdase_I:GlnA:rho:3a0501s007:glmS:recomb_XerC:NrdE_NrdA:addA_Gpos:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Central intermediary metabolism:Amino sugars:Energy metabolism:Electron transport:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Unknown function:General:Amino acid biosynthesis:Glutamate family:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 31 "NhaP-type Na+/H+ and K+/H+ antiporters:Lipoate-protein ligase A:Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels:Transcriptional regulator:Predicted permease:Predicted transcriptional regulators:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:ABC-type multidrug transport system, ATPase component:Hemolysins and related proteins containing CBS domains:Uncharacterized conserved protein:Histidinol phosphatase and related hydrolases of the PHP family:Predicted ABC-type exoprotein transport system, permease component:Uncharacterized protein conserved in bacteria:Uncharacterized conserved small protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Transcription:Inorganic ion transport and metabolism:Histidine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:Function unknown:a_cpa1:hisJ_fam:WXG100_ESAT6:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Cellular processes and signaling:Information storage and processing:Cations and iron carrying compounds:Transport and binding proteins:Poorly characterized:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism:Amino Acid Metabolism" 32 "ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:DNA repair photolyase:Uncharacterized protein conserved in bacteria:Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC:Amino acid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:ABC transporters:Function unknown:TIGR00282:photo_TT_lyase:Metabolism:Membrane Transport:Cellular processes:Sporulation and germination:Unknown function:Enzymes of unknown specificity:Information storage and processing:Cellular processes and signaling:Environmental Information Processing:Poorly characterized" 33 "Energy production and conversion:Predicted Fe-S oxidoreductases:5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases:N-acetylmuramoyl-L-alanine amidase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Threonine dehydrogenase and related Zn-dependent dehydrogenases:ABC-type multidrug transport system, ATPase component:D-mannonate dehydratase:Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases:Predicted esterase of the alpha-beta hydrolase superfamily:Malate/L-lactate dehydrogenases:Sugar phosphate permease:Uncharacterized conserved protein:Predicted membrane protein:Predicted symporter:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Pentose and glucuronate interconversions:Fructose and mannose metabolism:Purine metabolism:Pyrimidine metabolism:Bisphenol degradation:Chloroalkane and chloroalkene degradation:Butanoate metabolism:Metabolic pathways:Microbial metabolism in diverse environments:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:uxuA:sss:2A0114:SASP_H:spore_cwlD:Defense mechanisms:Metabolism:Cellular processes and signaling:Sporulation and germination:Cellular processes:Cations and iron carrying compounds:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Sugars:Energy metabolism:Metabolism:Metabolism:Global:Transcription:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Poorly characterized" 34 "Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:Transcription elongation factor:DnaJ-class molecular chaperone with C-terminal Zn finger domain:Translation initiation factor 2 (IF-2; GTPase):DNA polymerase sliding clamp subunit (PCNA homolog):ATPase involved in DNA replication initiation:2-methylthioadenine synthetase:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Uncharacterized protein conserved in bacteria:Recombinational DNA repair ATPase (RecF pathway):Ribosomal protein HS6-type (S12/L30/L7a):Uncharacterized protein conserved in bacteria:Ribosomal protein L11 methylase:Uncharacterized conserved protein:Predicted nucleic-acid-binding protein implicated in transcription termination:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyrimidine metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:DNA replication:Mismatch repair:Homologous recombination:Function unknown:TIGR00046:TIGR00089:small_GTP:DnaA:prmA:hemN_rel:recf:dnan:gyrB:gyrA:NusA:DnaJ_bact:YaaA_near_RecF:Metabolism:Poorly characterized:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Unknown function:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification:Protein synthesis:Transcription factors:Transcription:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Information storage and processing:Nucleotide Metabolism:Cellular processes and signaling" 35 "Transcriptional regulators:Dioxygenases related to 2-nitropropane dioxygenase:Predicted flavoproteins:Arabinose efflux permease:Carbohydrate transport and metabolism:Transcription:Nitrogen metabolism:General function prediction only:TIGR00275:Poorly characterized:Energy Metabolism:Unknown function:Enzymes of unknown specificity:Information storage and processing:Metabolism:Metabolism" 36 "Signal transduction histidine kinase:UDP-glucose 4-epimerase:Amidases related to nicotinamidase:Uncharacterized low-complexity proteins:Uncharacterized conserved protein:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Cytochrome P450:Na+/melibiose symporter and related transporters:ABC-type oligopeptide transport system, periplasmic component:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized conserved small protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Galactose metabolism:Amino sugar and nucleotide sugar metabolism:Biosynthesis of siderophore group nonribosomal peptides:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:Signal transduction mechanisms:tRNA_RlmH_YbeA:galE:spore_sigH:Poorly characterized:Cellular processes and signaling:Information storage and processing:Sporulation and germination:Cellular processes:tRNA and rRNA base modification:Protein synthesis:Sugars:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Transcription:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism:Carbohydrate Metabolism" 37 "Energy production and conversion:Putative translation factor (SUA5):Trk-type K+ transport systems, membrane components:Glycerol-3-phosphate dehydrogenase:Short-chain dehydrogenases of various substrate specificities:Thiamine monophosphate synthase:Uncharacterized conserved protein:Zn-dependent hydrolases, including glyoxylases:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Signal transduction histidine kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:A/G-specific DNA glycosylase:Uncharacterized conserved protein:D-Tyr-tRNAtyr deacylase:Transcriptional regulators:Membrane transporters of cations and cationic drugs:Hydroxyethylthiazole kinase, sugar kinase family:DNA polymerase III, alpha subunit (gram-positive type):Cation transport ATPase:Permeases:Copper chaperone:Arabinose efflux permease:Predicted carboxypeptidase:Putative NADH-flavin reductase:D-serine dehydratase:Superfamily I DNA and RNA helicases:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Lysine biosynthesis:Glycerophospholipid metabolism:Pyruvate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Thiamine metabolism:Metabolic pathways:Microbial metabolism in diverse environments:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00003:TIGR00057:TIGR00256:dnaq:thiE:thiM:efflux_EmrB:2a38:mutY:dipeptidaselike:D_Ser_am_lyase:Metabolism:Cellular processes and signaling:Information storage and processing:Thiamine:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Unknown function:Other:Cations and iron carrying compounds:Transport and binding proteins:tRNA aminoacylation:Protein synthesis:DNA replication, recombination, and repair:Degradation of DNA:DNA metabolism:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism" 38 "Amino acid transporters:Transcriptional regulator:Uncharacterized membrane-associated protein:Bacterial cell division membrane protein:Na+/H+ antiporter NhaD and related arsenite permeases:Gamma-aminobutyrate permease and related permeases:Branched-chain amino acid permeases:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Transcriptional regulator:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Uncharacterized conserved protein:Predicted acyltransferases:Transcriptional regulators:Membrane transporters of cations and cationic drugs:Na+/melibiose symporter and related transporters:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Predicted drug exporters of the RND superfamily:Arabinose efflux permease:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Inorganic ion transport and metabolism:Amino sugar and nucleotide sugar metabolism:Phosphotransferase system (PTS):RNA polymerase:General function prediction only:Function unknown:TIGR00159:livcs:EIIB_glc:2A0306:2a45:sigma70-ECF:Conserved:Hypothetical proteins:Other:Amino acids, peptides and amines:Transport and binding proteins:Membrane Transport:Environmental Information Processing:Transcription:Genetic Information Processing:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Metabolism:PTS:Signal transduction" 39 "Xaa-Pro aminopeptidase:Glutamate synthase domain 2:Co-chaperonin GroES (HSP10):Ribonuclease HI:Predicted amidohydrolase:Chaperonin GroEL (HSP60 family):Putative intracellular protease/amidase:Fe2+/Zn2+ uptake regulation proteins:UDP-glucose pyrophosphorylase:Regulators of stationary/sporulation gene expression:Cytochrome P450:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Galactose metabolism:Bisphenol degradation:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Polycyclic aromatic hydrocarbon degradation:Aminobenzoate degradation:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:DNA replication:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:galU:PfpI:lp_hng_hel_AbrB:GroEL:Protein fate:DNA interactions:Regulatory functions:Metabolism:Global:Replication and Repair:Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Cell envelope:Carbohydrate Metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Degradation of proteins, peptides, and glycopeptides:Protein folding and stabilization" 40 "Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Starch and sucrose metabolism:Metabolic pathways:Two-component system:Function unknown:Metabolism:Carbohydrate Metabolism:Environmental Information Processing:Signal Transduction:Global:Metabolism:Poorly characterized" 41 "Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:dTDP-D-glucose 4,6-dehydratase:dTDP-4-dehydrorhamnose reductase:dTDP-glucose pyrophosphorylase:Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog:Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:Sialic acid synthase:Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase:Uncharacterized protein conserved in bacteria:Cell wall/membrane/envelope biogenesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Function unknown:dTDP_gluc_dehyt:rmlD:Poorly characterized:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Global:Metabolism:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism" 42 "Energy production and conversion:Gamma-glutamyl phosphate reductase:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Ketol-acid reductoisomerase:3-isopropylmalate dehydratase large subunit:3-isopropylmalate dehydratase small subunit:Homoserine kinase:Isopropylmalate/homocitrate/citramalate synthases:Tryptophanyl-tRNA synthetase:Cysteinyl-tRNA synthetase:Glutamate 5-kinase:Cytidylate kinase:Acetolactate synthase, small (regulatory) subunit:Homoserine dehydrogenase:Isocitrate/isopropylmalate dehydrogenase:Threonine synthase:IMP dehydrogenase/GMP reductase:rRNA methylases:Na+/proline symporter:Adenine deaminase:Pyruvate carboxylase:Serine acetyltransferase:Uncharacterized protein conserved in bacteria:Methylase involved in ubiquinone/menaquinone biosynthesis:Predicted RNA-binding protein containing a PIN domain:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Citrate cycle (TCA cycle):Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Tryptophan metabolism:Pyruvate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Vitamin B6 metabolism:Pantothenate and CoA biosynthesis:Sulfur metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:cmk:acolac_lg:acolac_sm:leuB:leuC:leuD:rRNA_methyl_3:thrB:trpS:thrC:proA:cysS:ilvC:leuA_bact:proB:cysE:ade:pyruv_carbox:IMP_dehydrog:MenG_MenH_UbiE:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Purine ribonucleotide biosynthesis:Salvage of nucleosides and nucleotides:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Amino acid biosynthesis:Aspartate family:Glutamate family:Pyruvate family:Serine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Information storage and processing:Metabolism:Poorly characterized:Metabolism:Global:Metabolism:Translation:Genetic Information Processing" 43 "FOG: CBS domain:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:Membrane proteins related to metalloendopeptidases:Spore coat protein:Cell wall/membrane/envelope biogenesis:Purine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:GPR:spore_sspJ:spore_sspO:spore_YhcN_YlaJ:SASP_tlp:SASP_sspK:Cellular processes and signaling:Poorly characterized:Cellular processes:Metabolism:Metabolism:Global:Sporulation and germination:Nucleotide Metabolism" 44 "Energy production and conversion:Predicted redox protein, regulator of disulfide bond formation:Zn-dependent hydrolases, including glyoxylases:Rhodanese-related sulfurtransferase:Predicted permeases:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:N-acetylmuramoyl-L-alanine amidase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):UDP-glucose pyrophosphorylase:Phosphotransferase system cellobiose-specific component IIC:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Membrane transporters of cations and cationic drugs:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:Predicted membrane protein:Predicted membrane protein:Predicted transcriptional regulator:Phage-related holin (Lysis protein):Uncharacterized protein conserved in bacteria:N-acetylmuramoyl-L-alanine amidase:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Galactose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Phosphotransferase system (PTS):RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:cello_pts_IIC:galU:holin_tox_secr:spore_ger_x_C:sigma70-ECF:oxido_grp_1:Cell envelope:PTS:Signal transduction:Enzymes of unknown specificity:Unknown function:Prophage functions:Mobile and extrachromosomal element functions:Sporulation and germination:Cellular processes:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Transcription:Genetic Information Processing:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides" 45 "ATPases involved in chromosome partitioning:Chemotaxis protein histidine kinase and related kinases:Chemotaxis signal transduction protein:Flagellar biosynthesis pathway, component FlhA:Flagellar biosynthesis pathway, component FlhB:Flagellar GTP-binding protein:Chemotaxis protein; stimulates methylation of MCP proteins:Flagellar biosynthesis pathway, component FliQ:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:ABC-type polysaccharide transport system, permease component:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Cell motility:Two-component system:Bacterial chemotaxis:Flagellar assembly:Signal transduction mechanisms:flhB:FlhA:fliQ:FlhF:Intracellular trafficking, secretion, and vesicular transport:Signal Transduction:Chemotaxis and motility:Cellular processes and signaling:Metabolism:Environmental Information Processing:Cell Motility:Cellular Processes:Cellular processes" 46 "Energy production and conversion:ABC-type nitrate/sulfonate/bicarbonate transport system, permease component:ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component:Sialic acid synthase:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:Membrane protein involved in the export of O-antigen and teichoic acid:Uncharacterized protein conserved in bacteria:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:ABC transporters:General function prediction only:Function unknown:alk_sulf_monoox:Metabolism:Environmental Information Processing:Poorly characterized:Cellular processes and signaling:Sulfur metabolism:Central intermediary metabolism:Membrane Transport" 47 "Zn-dependent protease with chaperone function:Integrase:Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster:Phosphotransferase system IIA components:ATPase related to the helicase subunit of the Holliday junction resolvase:Lysophospholipase L1 and related esterases:Predicted Zn peptidase:Predicted transcriptional regulator:Phage-related replication protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Phosphotransferase system (PTS):General function prediction only:PTBA:DivI1A_domain:Poorly characterized:Carbohydrate Metabolism:Environmental Information Processing:Membrane Transport:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 48 "Arginase/agmatinase/formimionoglutamate hydrolase, arginase family:Dimethyladenosine transferase (rRNA methylation):Acetyltransferases:Phosphatidylglycerophosphate synthase:K+ transport systems, NAD-binding component:ABC-type Fe3+-siderophore transport system, permease component:ABC-type Fe3+-hydroxamate transport system, periplasmic component:Sulfate permease and related transporters (MFS superfamily):Membrane-associated phospholipid phosphatase:Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA:HD superfamily phosphohydrolases:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:Predicted GTPases:Flagellar motor component:Flagellar motor protein:Small primase-like proteins (Toprim domain):Uncharacterized conserved protein:Predicted hydrolase of the HAD superfamily:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Uncharacterized conserved protein:Signal transduction histidine kinase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell motility:Inorganic ion transport and metabolism:Arginine and proline metabolism:Glycerophospholipid metabolism:Metabolic pathways:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:molyb_syn:5S_RNA_mat_M5:pgsA:PduO_Nterm:ksgA:sulP:agmatinase:HAD-SF-IA-v1:rimI:GTPase_YqeH:Anions:Transport and binding proteins:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification:Other:Protein synthesis:RNA processing:Transcription:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Membrane Transport:Environmental Information Processing:Amino Acid Metabolism:Information storage and processing:Lipid Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function" 49 "Carbonic anhydrase:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Transcriptional regulator:Predicted transcriptional regulators:Putative intracellular protease/amidase:Predicted xylanase/chitin deacetylase:Fe2+/Zn2+ uptake regulation proteins:Catalase:Arsenite efflux pump ACR3 and related permeases:Predicted transcriptional regulators:Transcriptional regulators:Acetyltransferases, including N-acetylases of ribosomal proteins:Predicted transcriptional regulators:Phage shock protein A (IM30), suppresses sigma54-dependent transcription:LuxS protein involved in autoinducer AI2 synthesis:Site-specific recombinases, DNA invertase Pin homologs:Sugar phosphate permease:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Tryptophan metabolism:Methane metabolism:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:YbaK_EbsC:acr3:Bac_small_yrzI:Unknown function:Anions:Transport and binding proteins:General:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Metabolism:Global:Poorly characterized:Signal Transduction:Environmental Information Processing:Amino Acid Metabolism:Energy Metabolism" 50 "Energy production and conversion:Malic enzyme:Lactoylglutathione lyase and related lyases:Sulfite reductase, alpha subunit (flavoprotein):Predicted esterase:DNA repair exonuclease:Zn-dependent hydrolases, including glyoxylases:Na+-driven multidrug efflux pump:Uracil DNA glycosylase:UDP-N-acetylmuramate dehydrogenase:Chromosome segregation ATPases:Glycosyltransferases, probably involved in cell wall biogenesis:Phosphotransferase system, fructose-specific IIC component:Transcriptional regulator:Amidases related to nicotinamidase:Transcriptional regulators:Integral membrane protein CcmA involved in cell shape determination:Nucleoside permease:AraC-type DNA-binding domain-containing proteins:Cation transport ATPase:Copper chaperone:Arabinose efflux permease:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Fatty acid metabolism:Tryptophan metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Pyruvate metabolism:Aminobenzoate degradation:Biosynthesis of siderophore group nonribosomal peptides:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Phosphotransferase system (PTS):Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:TIGR00003:murB:sbcd:ung:efflux_EmrB:matE:nupC:FRU:Defense mechanisms:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Global:Signal Transduction:Metabolism:Membrane Transport:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Lipid Metabolism:PTS:Carbohydrate Metabolism:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Signal transduction:Other:Nucleosides, purines and pyrimidines:Cations and iron carrying compounds:Transport and binding proteins" 51 "Polyprenyltransferase (cytochrome oxidase assembly factor):Nucleotidyltransferase/DNA polymerase involved in DNA repair:Transcriptional regulator:Preprotein translocase subunit YidC:Predicted xylanase/chitin deacetylase:Fe2+/Zn2+ uptake regulation proteins:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1:Predicted membrane protein, hemolysin III homolog:Putative copper export protein:Transcriptional regulators of sugar metabolism:Uncharacterized protein required for cytochrome oxidase assembly:Uncharacterized proteins, homologs of microcin C7 resistance protein MccF:Transcriptional regulators:Teichoic acid biosynthesis proteins:Uncharacterized protein conserved in bacteria:Arginine/lysine/ornithine decarboxylases:Predicted membrane protein:Arabinose efflux permease:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Negative regulator of genetic competence, sporulation and motility:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Arginine and proline metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:wecG_tagA_cpsF:hlyIII:cyoE_ctaB:yidC_oxa1_cterm:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Energy Metabolism:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Protein and peptide secretion and trafficking:Protein fate:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Heme, porphyrin, and cobalamin" 52 "Energy production and conversion:Carbonic anhydrase:Lactoylglutathione lyase and related lyases:Transcriptional regulator:N-acetylmuramoyl-L-alanine amidase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type multidrug transport system, ATPase component:UDP-glucose pyrophosphorylase:Lysine efflux permease:Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs:Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs:Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs:Predicted membrane protein:Transthyretin-like protein:Holliday junction resolvase:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Predicted integral membrane protein:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Galactose metabolism:Purine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:galU:hdxy_isourate:pucD:pucE:pucC:Defense mechanisms:Carbohydrate Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:Other:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Nucleotide Metabolism:Energy Metabolism:Information storage and processing" 53 "Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:tmRNA-binding protein:Thioredoxin-like proteins and domains:Histidinol phosphatase and related hydrolases of the PHP family:Uncharacterized protein with SCP/PR1 domains:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Posttranslational modification, protein turnover, chaperones:Histidine metabolism:Pyruvate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:smpB:hisJ_fam:Protein synthesis:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Global:Metabolism:Metabolism:Other:Cellular processes and signaling:Metabolism:Poorly characterized" 54 "Thymidylate kinase:Excinuclease ATPase subunit:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:ATPase involved in DNA replication:Helicase subunit of the DNA excision repair complex:DNA polymerase III, alpha subunit:Small-conductance mechanosensitive channel:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Sugar (pentulose and hexulose) kinases:ABC-type multidrug transport system, ATPase and permease components:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Integral membrane protein CcmA involved in cell shape determination:Uncharacterized protein conserved in bacteria:Uncharacterized homolog of PSP1:Transcriptional regulator/sugar kinase:Arginine/lysine/ornithine decarboxylases:Predicted membrane protein:Uncharacterized protein involved in tellurite resistance:ATP-dependent nuclease, subunit B:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:5-bromo-4-chloroindolyl phosphate hydrolysis protein:Integral membrane protein (PIN domain superfamily):Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Galactose metabolism:Purine metabolism:Pyrimidine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:RNA polymerase:DNA replication:Nucleotide excision repair:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:DTMP_kinase:polc:uvra:uvrb:holB:ROK_glcA_fam:gntK_FGGY:addB_Gpos:sigma70-ECF:Defense mechanisms:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:General:Unknown function:DNA replication, recombination, and repair:DNA metabolism:Nucleotide and nucleoside interconversions:Purines, pyrimidines, nucleosides, and nucleotides:Sugars:Energy metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Replication and Repair:Transcription:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Nucleotide Metabolism:Carbohydrate Metabolism" 55 "Energy production and conversion:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Glycosyltransferases involved in cell wall biogenesis:Superfamily II DNA/RNA helicases, SNF2 family:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Amino acid permeases:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit:Uncharacterized conserved protein:Na+/H+-dicarboxylate symporters:Uncharacterized conserved protein:Phosphoenolpyruvate carboxykinase (ATP):H+/gluconate symporter and related permeases:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Valine leucine and isoleucine biosynthesis:Pyruvate metabolism:Butanoate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Non-homologous end-joining:General function prediction only:Function unknown:pckA:2A0309:GAPDH-I:Ku_bact:spore_ger_x_C:Cellular processes and signaling:Carbohydrate Metabolism:Amino Acid Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Amino acids, peptides and amines:Cellular processes:Sporulation and germination:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 56 "Molecular chaperone (small heat shock protein):3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes:Amino acid transporters:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component:DnaK suppressor protein:Uncharacterized conserved protein:Phosphosulfolactate phosphohydrolase and related enzymes:Thermophilic glucose-6-phosphate isomerase and related metalloenzymes:Predicted membrane protein:Putative glucose uptake permease:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Sulfur metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:cysH:RhaT:spore_yteA:bicupin_oxalic:Metabolism:Global:Membrane Transport:Environmental Information Processing:Energy Metabolism:Cellular processes:Carbohydrate Metabolism:Sporulation and germination:Cellular processes and signaling:Metabolism:Poorly characterized:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Sulfur metabolism:Central intermediary metabolism:Metabolism" 57 "Energy production and conversion:Adenylosuccinate lyase:Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase):Glutamine phosphoribosylpyrophosphate amidotransferase:Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain:Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain:AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful):Phosphoribosylaminoimidazole (AIR) synthetase:Phosphoribosylamine-glycine ligase:Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase:Dihydroorotate dehydrogenase:Orotidine-5'-phosphate decarboxylase:Folate-dependent phosphoribosylglycinamide formyltransferase PurN:Orotate phosphoribosyltransferase:Carbamoylphosphate synthase small subunit:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:One carbon pool by folate:Metabolic pathways:Biosynthesis of secondary metabolites:purC:TIGR00302:pyrE:purH:PurN:purD:purM:purB:pyrD_sub1_fam:purF:purK:CPSaseIIsmall:FGAM_synth_II:FGAM_synth_I:pyrF:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Metabolism:Nucleotide Metabolism:Pyrimidine ribonucleotide biosynthesis:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global" 58 "Site-specific DNA methylase:Protein involved in ribonucleotide reduction:Penicillin-binding protein-related factor A, putative recombinase:Nucleotide transport and metabolism:Replication, recombination and repair:Cysteine and methionine metabolism:Metabolic pathways:General function prediction only:nrdI:dcm:Poorly characterized:DNA metabolism:Amino Acid Metabolism:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:Metabolism:DNA replication, recombination, and repair:Information storage and processing:Metabolism" 59 "Energy production and conversion:Predicted sugar kinase:Ca2+/H+ antiporter:Di- and tricarboxylate transporters:Catalase:NAD-dependent aldehyde dehydrogenases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):N-acetylglutamate synthase and related acetyltransferases:Phospholipid-binding protein:3-methyladenine DNA glycosylase:Uncharacterized conserved protein:Arabinose efflux permease:Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog):Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Fatty acid metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Propanoate metabolism:Methane metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:yjeF_cterm:cax:TIGR00481:3mg:dass:SP:2A0309:spore_II_R:Cations and iron carrying compounds:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Amino acids, peptides and amines:Carbohydrates, organic alcohols, and acids:Metabolism:Cellular processes:Sporulation and germination:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 60 "Integral membrane protein, interacts with FtsH:3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases:Lipid transport and metabolism:General function prediction only:Metabolism:Poorly characterized" 61 "Glycosidases:ABC-type sugar transport system, permease component:UDP-N-acetylmuramoylalanine-D-glutamate ligase:Sugar (pentulose and hexulose) kinases:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Phosphotransferase system, fructose-specific IIC component:Transcriptional regulators of sugar metabolism:Phosphomannose isomerase:ABC-type sugar transport system, periplasmic component:Na+/melibiose symporter and related transporters:Beta-glucanase/Beta-glucan synthetase:H+/gluconate symporter and related permeases:Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase:Uncharacterized conserved protein:Transcriptional antiterminator:L-rhamnose isomerase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Fructose and mannose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Phosphotransferase system (PTS):Function unknown:manA:gntP:gph:EIIB_glc:FRU:rhaA:trehalose_treC:YiiL_rotase:rhamnulo_kin:poly_gGlu_PgsC:poly_gGlu_PgsB:Poorly characterized:Carbohydrate Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Sugars:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Signal transduction:PTS:Cell envelope:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 62 "Energy production and conversion:Dihydroorotase and related cyclic amidohydrolases:Ribosomal protein L7/L12:Ribosome recycling factor:Acetate kinase:Asparagine synthase (glutamine-hydrolyzing):Spermidine synthase:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:Uridylate kinase:Aspartate carbamoyltransferase, catalytic chain:Pseudouridylate synthases, 23S RNA-specific:RNase P protein component:Lipoprotein signal peptidase:UDP-N-acetylmuramyl tripeptide synthase:UDP-N-acetylmuramoylalanine-D-glutamate ligase:Bacterial cell division membrane protein:Actin-like ATPase involved in cell morphogenesis:Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase:Xanthine/uracil permeases:16S RNA G1207 methylase RsmC:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Arginine and proline metabolism:beta-Alanine metabolism:Taurine and hypotaurine metabolism:D-Glutamine and D-glutamate metabolism:Glutathione metabolism:Peptidoglycan biosynthesis:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:Protein export:rluA_subfam:ackA:lspA:rnpA:speE:mraY:frr:asp_carb_tr:ncs2:L12:pyrC_multi:mreB:murE:murD:asn_synth_AEB:pyrH_bact:ftsW:Intracellular trafficking, secretion, and vesicular transport:Cell division:Amino acid biosynthesis:Aspartate family:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Metabolism:Translation:Genetic Information Processing:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism:Central intermediary metabolism:Polyamine biosynthesis:Energy metabolism:Fermentation:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Pyrimidine ribonucleotide biosynthesis:Transcription:RNA processing:Protein synthesis:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Nucleosides, purines and pyrimidines:Cellular processes" 63 "Energy production and conversion:Purine nucleoside phosphorylase:Cell division GTPase:Predicted enzyme with a TIM-barrel fold:Glucose-6-phosphate 1-dehydrogenase:ATP-dependent Lon protease, bacterial type:Ribosomal protein S1:ABC-type Fe3+-hydroxamate transport system, periplasmic component:Predicted permease:Predicted dehydrogenases and related proteins:Parvulin-like peptidyl-prolyl isomerase:Predicted integral membrane protein:UDP-N-acetylglucosamine enolpyruvyl transferase:Transcription elongation factor:Actin-like ATPase involved in cell division:Phosphopentomutase:Uncharacterized conserved protein containing a ferredoxin-like domain:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted kinase related to dihydroxyacetone kinase:Nicotinic acid phosphoribosyltransferase:Uncharacterized conserved protein:Uncharacterized conserved protein:Transcriptional regulators:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Negative regulator of septation ring formation:Uncharacterized integral membrane protein:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Purine metabolism:Pyrimidine metabolism:Glutathione metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Nicotinate and nicotinamide metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Ribosome:General function prediction only:Function unknown:TIGR00044:ftsZ:TIGR00273:TIGR00726:lon:zwf:murA:ftsA:greA:ccpA:NAPRTase_put:deoB:PNPH-PUNA-XAPA:YloV:Degradation of proteins, peptides, and glycopeptides:Protein fate:Transcription factors:Transcription:DNA interactions:Regulatory functions:Other:Purines, pyrimidines, nucleosides, and nucleotides:Pentose phosphate pathway:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Nucleotide Metabolism:Enzymes of unknown specificity:Carbohydrate Metabolism:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Unknown function:Cell division:Cellular processes" 64 "Energy production and conversion:1-acyl-sn-glycerol-3-phosphate acyltransferase:Integral membrane protein possibly involved in chromosome condensation:Ribosomal protein L33:3-hexulose-6-phosphate synthase and related proteins:Dienelactone hydrolase and related enzymes:Uncharacterized conserved protein:Predicted sugar phosphate isomerase involved in capsule formation:Membrane protein TerC, possibly involved in tellurium resistance:Na+/alanine symporter:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Phosphatidylglycerophosphatase A and related proteins:Acetyltransferases, including N-acetylases of ribosomal proteins:LuxS protein involved in autoinducer AI2 synthesis:Aromatic ring hydroxylase:Predicted transcriptional regulator:Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation):Predicted Zn peptidase:Na+/citrate symporter:Cell division initiation protein:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Cysteine and methionine metabolism:Tyrosine metabolism:Methane metabolism:Microbial metabolism in diverse environments:Two-component system:Ribosome:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:Signal transduction mechanisms:TIGR00278:crcB:AGP_acyltrn:ccs:agcS:rpmG_bact:HpaB-1:RuMP_HxlB:RuMP_HxlA:DivI1A_domain:R_switched_YjbE:Role category not yet assigned:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Protein synthesis:Ribosomal proteins: synthesis and modification:Hypothetical proteins:Conserved:Unknown function:General:Unclassified:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 65 "Energy production and conversion:Thioredoxin reductase:ABC-type Fe3+-siderophore transport system, permease component:ABC-type Fe3+-hydroxamate transport system, periplasmic component:High-affinity Fe2+/Pb2+ permease:Flavodoxins:Nitroreductase:Non-ribosomal peptide synthetase modules and related proteins:Peptide arylation enzymes:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:Isochorismate synthase:Isochorismate hydrolase:Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides:Predicted hydrolase of the alpha/beta superfamily:Predicted periplasmic lipoprotein involved in iron transport:Predicted iron-dependent peroxidase:Coenzyme transport and metabolism:Lipid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Pyrimidine metabolism:Biosynthesis of siderophore group nonribosomal peptides:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:isochor_syn:tat_substr_1:AA-adenyl-dom:flav_short:DHB_AMP_lig:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Cellular processes and signaling:Nucleotide Metabolism:Metabolism:Poorly characterized:Menaquinone and ubiquinone:Biosynthesis of cofactors, prosthetic groups, and carriers:Cations and iron carrying compounds:Transport and binding proteins:Electron transport:Energy metabolism" 66 "Cysteine synthase:Ribonucleotide reductase, beta subunit:Pyrroline-5-carboxylate reductase:Transcriptional regulator:ABC-type Fe3+-siderophore transport system, permease component:Multimeric flavodoxin WrbA:MoxR-like ATPases:Predicted xylanase/chitin deacetylase:Gamma-aminobutyrate permease and related permeases:Acyl carrier protein phosphodiesterase:Phosphatidylserine synthase:Uncharacterized conserved protein:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain):Membrane transporters of cations and cationic drugs:Membrane protein involved in the export of O-antigen and teichoic acid:Arabinose efflux permease:Transcriptional antiterminator:Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Selenocompound metabolism:Glycerophospholipid metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:General function prediction only:Function unknown:proC:TIGR00375:mazG:pssA:efflux_Bcr_CflA:cysKM:spore_pdaA:Hypothetical proteins:Sporulation and germination:Cellular processes:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Global:Metabolism:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Serine family:Energy Metabolism:Information storage and processing:Metabolism:Poorly characterized:Glutamate family:Amino acid biosynthesis:General:Unknown function:Conserved" 67 "Predicted EndoIII-related endonuclease:Aspartate/tyrosine/aromatic aminotransferase:Glycosyltransferases involved in cell wall biogenesis:Na+-driven multidrug efflux pump:Na+-dependent transporters of the SNF family:Membrane carboxypeptidase (penicillin-binding protein):Formyltetrahydrofolate hydrolase:Type II restriction enzyme, methylase subunits:Predicted branched-chain amino acid permease (azaleucine resistance):Transglutaminase-like enzymes, putative cysteine proteases:Transcriptional regulators:Predicted branched-chain amino acid permeases (azaleucine resistance):Nucleoside permease:DNA polymerase III, alpha subunit (gram-positive type):SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Sugar phosphate permease:Arabinose efflux permease:Penicillin-binding protein-related factor A, putative recombinase:Putative primosome component and related proteins:Predicted membrane protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Purine metabolism:Pyrimidine metabolism:Histidine metabolism:Tyrosine metabolism:Selenocompound metabolism:Peptidoglycan biosynthesis:Polycyclic aromatic hydrocarbon degradation:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:Metabolic pathways:Microbial metabolism in diverse environments:DNA replication:Base excision repair:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:azlC:rumA:dnaq:recU:PurU:efflux_EmrB:matE:nupC:nth:DnaD_dom:PBP_1a_fam:Defense mechanisms:Poorly characterized:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Global:Metabolism:Replication and Repair:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:DNA metabolism:Carbohydrate Metabolism:Degradation of DNA:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Amino acids, peptides and amines:Nucleosides, purines and pyrimidines:Other:Mobile and extrachromosomal element functions:Prophage functions:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism" 68 "Energy production and conversion:Excinuclease ATPase subunit:Nitrogen regulatory protein PII:Molecular chaperone:ATPases with chaperone activity, ATP-binding subunit:Helicase subunit of the DNA excision repair complex:Molecular chaperone GrpE (heat shock protein):Transcriptional regulator:Predicted Zn-dependent peptidases:Predicted permeases:5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases:Protease subunit of ATP-dependent Clp proteases:Nitroreductase:Predicted ATP-dependent serine protease:Uncharacterized conserved protein:Transcriptional regulator of heat shock gene:Predicted nucleic-acid-binding protein (contains the HHH domain):Acetyltransferases, including N-acetylases of ribosomal proteins:Uncharacterized conserved protein:Glycerate kinase:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Lysophospholipase:Arginine kinase:Uncharacterized protein with conserved CXXC pairs:Transcriptional repressor of class III stress genes:5-bromo-4-chloroindolyl phosphate hydrolysis protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Glycine serine and threonine metabolism:Starch and sucrose metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:RNA degradation:Nucleotide excision repair:General function prediction only:Function unknown:TIGR00045:hrcA:sms:clpP:uvra:uvrb:prok_dnaK:YtoQ_fam:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Degradation of proteins, peptides, and glycopeptides:Protein folding and stabilization:Protein fate:DNA replication, recombination, and repair:DNA metabolism:DNA interactions:Regulatory functions:Other:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism" 69 "Replicative DNA helicase:Uncharacterized membrane-associated protein:Small-conductance mechanosensitive channel:Transcriptional regulator:Uncharacterized conserved protein:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:DNA replication:Function unknown:DnaB:efflux_EmrB:Cellular processes and signaling:Replication and Repair:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Other:Information storage and processing:Genetic Information Processing:Poorly characterized" 70 "Energy production and conversion:Uncharacterized conserved protein:Fumarase:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase:Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels:Predicted hydrolases of the HAD superfamily:Protease subunit of ATP-dependent Clp proteases:Cell division protein FtsI/penicillin-binding protein 2:Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis):4-diphosphocytidyl-2-methyl-D-erithritol synthase:Uncharacterized conserved protein:Putative NADPH-quinone reductase (modulator of drug activity B):Septum formation initiator:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Carbon fixation pathways in prokaryotes:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:Cof-subfamily:TIGR00106:ispF:tRNA_RlmH_YbeA:RNAse_H_YqgF:ispD:clpP:fumC_II:Intracellular trafficking, secretion, and vesicular transport:General:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Terpenoids and Polyketides:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:TCA cycle:Protein synthesis:tRNA and rRNA base modification:Protein fate:Degradation of proteins, peptides, and glycopeptides:Unknown function:Enzymes of unknown specificity:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 71 "Tyrosyl-tRNA synthetase:Mannitol-1-phosphate/altronate dehydrogenases:Predicted redox protein, regulator of disulfide bond formation:Glycosyltransferase:Zn-dependent hydrolases, including glyoxylases:ABC-type antimicrobial peptide transport system, permease component:Na+/proline symporter:Rhodanese-related sulfurtransferase:Signal transduction histidine kinase:Permeases of the drug/metabolite transporter (DMT) superfamily:Predicted permeases:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type antimicrobial peptide transport system, ATPase component:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Phosphomannose isomerase:Transcriptional regulator/sugar kinase:Homocysteine/selenocysteine methylase (S-methylmethionine-dependent):Transcriptional regulators:Uncharacterized conserved protein:Sugar phosphate permease:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Fructose and mannose metabolism:Cysteine and methionine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:manA:tyrS:Defense mechanisms:Amino Acid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:tRNA aminoacylation:Protein synthesis:Sugars:Metabolism:Energy metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing" 72 "Energy production and conversion:ATP phosphoribosyltransferase:Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase:Imidazoleglycerol-phosphate synthase:Glutamine amidotransferase:Imidazoleglycerol-phosphate dehydratase:Phosphoribosyl-AMP cyclohydrolase:Histidinol dehydrogenase:Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Multisubunit Na+/H+ antiporter, MnhC subunit:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:ABC-type polar amino acid transport system, ATPase component:Multisubunit Na+/H+ antiporter, MnhG subunit:Multisubunit Na+/H+ antiporter, MnhE subunit:Predicted permease:Multisubunit Na+/H+ antiporter, MnhB subunit:Multisubunit Na+/H+ antiporter, MnhF subunit:Predicted membrane protein:ATP phosphoribosyltransferase involved in histidine biosynthesis:Amino acid transport and metabolism:Inorganic ion transport and metabolism:Histidine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00007:hisD:hisG:hisZ_biosyn_reg:hisF:2a6301s01:2a6301s02:2a6301s04:CPA3_mnhG_phaG:HEQRo_perm_3TM:IMP_synth_hisH:histidine_hisI:Amino acids, peptides and amines:Transport and binding proteins:Metabolism:Metabolism:Global:Poorly characterized:Amino Acid Metabolism:Metabolism:Cellular processes and signaling:Histidine family:Amino acid biosynthesis:Cations and iron carrying compounds" 73 "Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:ABC-type multidrug transport system, ATPase and permease components:Transcriptional regulators:H+/gluconate symporter and related permeases:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Ubiquinone and other terpenoid-quinone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:gntP:menE:Defense mechanisms:Information storage and processing:Metabolism of Cofactors and Vitamins:Global:Metabolism:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Metabolism:Cellular processes and signaling:Metabolism" 74 "Energy production and conversion:Predicted Co/Zn/Cd cation transporters:Proline dehydrogenase:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Cytochrome bd-type quinol oxidase, subunit 2:DNA replication protein:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Formate/nitrite family of transporters:Predicted membrane protein:Fucose 4-O-acetylase and related acetyltransferases:Predicted membrane protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Oxidative phosphorylation:Arginine and proline metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:RNA polymerase:General function prediction only:Function unknown:fnt:CDF:tape_meas_TP901:sigma70-ECF:Cellular processes and signaling:Energy Metabolism:Amino Acid Metabolism:Genetic Information Processing:Transcription:Global:Metabolism:Transport and binding proteins:Anions:Cations and iron carrying compounds:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 75 "Aspartyl-tRNA synthetase:Glutamine synthetase:ATPase components of ABC transporters with duplicated ATPase domains:ATPases involved in chromosome partitioning:SAM-dependent methyltransferases:Metal-dependent proteases with possible chaperone activity:Predicted PP-loop superfamily ATPase:Phosphatidylserine decarboxylase:Predicted ATPase or kinase:Na+/alanine symporter:D-alanine-D-alanine ligase and related ATP-grasp enzymes:ABC-type transport system involved in multi-copper enzyme maturation, permease component:Transcriptional regulator:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:Serine phosphatase RsbU, regulator of sigma subunit:Uncharacterized protein conserved in bacteria:Protein affecting phage T7 exclusion by the F plasmid:Protein involved in sex pheromone biosynthesis:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:D-Alanine metabolism:Peptidoglycan biosynthesis:Glycerophospholipid metabolism:Nitrogen metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:HI0065_YjeE:PS_decarb:sensory_box:gcp_kae1:TIGR00364:aspS_bact:GlnA:agcS:eps_fam:D_ala_D_alaTIGR:Cellular processes and signaling:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA aminoacylation:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Glutamate family:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 76 "Ribosomal protein S10:Ribosomal protein L3:Ribosomal protein L4:Ribosomal protein L23:Ribosomal protein L2:Ribosomal protein L22:Ribosomal protein S3:Ribosomal protein L14:Ribosomal protein L5:Ribosomal protein L6P/L9E:Ribosomal protein S19:Ribosomal protein S17:Ribosomal protein L16/L10E:Ribosomal protein L29:Translation, ribosomal structure and biogenesis:Ribosome:L29:rpsC_bact:rplV_bact:rpsJ_bact:rpsS_bact:rplN_bact:rplP_bact:rplB_bact:L3_bact:S17_bact:L6_bact:rplD_bact:Ribosomal proteins: synthesis and modification:Translation:Protein synthesis:Genetic Information Processing:Information storage and processing" 77 "Energy production and conversion:Predicted sugar kinase:Uncharacterized conserved protein:Predicted GTPase:Lactoylglutathione lyase and related lyases:Thiol-disulfide isomerase and thioredoxins:Glycerophosphoryl diester phosphodiesterase:Ribose 5-phosphate isomerase RpiB:Nitroreductase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Uncharacterized conserved protein:Arsenate reductase and related proteins, glutaredoxin family:Acyl-CoA hydrolase:NADH:flavin oxidoreductases, Old Yellow Enzyme family:Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family:3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:Putative NADPH-quinone reductase (modulator of drug activity B):Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Fructose and mannose metabolism:Valine leucine and isoleucine degradation:Bisphenol degradation:Glycerophospholipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Butanoate metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:small_GTP:rpiB_lacA_lacB:TIGR01033:thioredoxin:TIGR01440:arsC_related:oxido_grp_1:Metabolism:Cellular processes and signaling:General:Enzymes of unknown specificity:Unknown function:Conserved:Hypothetical proteins:DNA interactions:Regulatory functions:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:Poorly characterized:Carbohydrate Metabolism" 78 "FAD synthase:Lactoylglutathione lyase and related lyases:6-phosphogluconate dehydrogenase:Glucose-6-phosphate 1-dehydrogenase:Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family:Zn-dependent hydrolases, including glyoxylases:Glycine cleavage system H protein (lipoate-binding):Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Superoxide dismutase:Predicted transcriptional regulators:Transcription elongation factor:Adenine-specific DNA methylase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ATP-dependent protease Clp, ATPase subunit:Predicted RNA-binding protein homologous to eukaryotic snRNP:Cellulase M and related proteins:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Predicted redox protein, regulator of disulfide bond formation:Peroxiredoxin:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Glutathione metabolism:Streptomycin biosynthesis:Inositol phosphate metabolism:Pyruvate metabolism:Riboflavin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:ribF:clpX:gcvH:zwf:gnd:greA:perox_SACOL1771:thiol_BshC:Metabolism:Carbohydrate Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Global:Metabolism:Energy metabolism:Amino acids and amines:Pentose phosphate pathway:Transcription:Transcription factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Glutathione and analogs:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 79 "Energy production and conversion:Alanyl-tRNA synthetase:Sulfite reductase, beta subunit (hemoprotein):Acetyl-CoA acetyltransferase:Mismatch repair ATPase (MutS family):Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis:Acetate kinase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Sulfite reductase, alpha subunit (flavoprotein):Acetyltransferases:GMP synthase, PP-ATPase domain/subunit:Glycyl-tRNA synthetase, beta subunit:Glycyl-tRNA synthetase, alpha subunit:Gamma-aminobutyrate permease and related permeases:Uncharacterized conserved protein:D-alanyl-D-alanine carboxypeptidase:Uncharacterized conserved protein:Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides:Amino acid transport and metabolism:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Fatty acid metabolism:Synthesis and degradation of ketone bodies:Purine metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Benzoate degradation:Tryptophan metabolism:Taurine and hypotaurine metabolism:Peptidoglycan biosynthesis:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Terpenoid backbone biosynthesis:Sulfur metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Mismatch repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00006:ackA:glyS:alaS:glyQ:guaA_Cterm:mutS1:AcCoA-C-Actrans:cysJ:CysI:tRNA aminoacylation:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:DNA metabolism:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Other:Metabolism:Global:Fatty acid and phospholipid metabolism:Signal Transduction:Fermentation:Energy metabolism:Sulfur metabolism:Environmental Information Processing:Central intermediary metabolism:Replication and Repair:Translation:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism:Metabolism of Terpenoids and Polyketides:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:DNA replication, recombination, and repair:Carbohydrate Metabolism:Protein synthesis" 80 "Energy production and conversion:Cysteine synthase:Leucyl aminopeptidase:SAM-dependent methyltransferases:Transcriptional regulator:Cystathionine beta-lyases/cystathionine gamma-synthases:Integral membrane protein, interacts with FtsH:ABC-type amino acid transport system, permease component:Cell division protein FtsI/penicillin-binding protein 2:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type polar amino acid transport system, ATPase component:Inorganic pyrophosphatase/exopolyphosphatase:Metal-dependent amidase/aminoacylase/carboxypeptidase:Uroporphyrinogen-III synthase:Predicted redox protein, regulator of disulfide bond formation:Predicted Na+/dicarboxylate symporter:Acyl-CoA dehydrogenases:Uncharacterized protein involved in propionate catabolism:Formate/nitrite family of transporters:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:Ethanolamine utilization protein:Acetyl esterase (deacetylase):Predicted nucleotidyltransferase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Cysteine and methionine metabolism:Penicillin and cephalosporin biosynthesis:Arginine and proline metabolism:Selenocompound metabolism:Glutathione metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:fnt:cysKM:cobA_cysG_Cterm:HEQRo_perm_3TM:amidohydrolases:organ_hyd_perox:FMN_nitrolo:Cellular processes:Anions:Amino acids, peptides and amines:Transport and binding proteins:Degradation of proteins, peptides, and glycopeptides:Protein fate:Metabolism:Metabolism:Global:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Cellular processes and signaling:Energy Metabolism:Metabolism:Poorly characterized:Information storage and processing:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:Serine family:Amino acid biosynthesis:Enzymes of unknown specificity:Unknown function:Detoxification" 81 "Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Highly conserved protein containing a thioredoxin domain:3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Cellular processes and signaling:Metabolism" 82 "Methionine aminopeptidase:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Thioredoxin reductase:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Predicted HD superfamily hydrolase:Acyl-CoA hydrolase:Uncharacterized protein conserved in bacteria:GAF domain-containing protein:Predicted membrane-bound metal-dependent hydrolases:Zn-dependent proteases:Truncated hemoglobins:Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis:Arabinose efflux permease:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase regulating citrate/malate metabolism:Response regulator of citrate/malate metabolism:Negative regulator of genetic competence, sporulation and motility:Uncharacterized protein conserved in bacteria:Transcriptional regulator, effector-binding domain/component:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Vitamin B6 metabolism:Metabolic pathways:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:HMP-P_kinase:sensory_box:HDIG:met_pdase_I:lysidine_TilS_N:Bthiol_YpdA:Metabolism:Global:Signal Transduction:Environmental Information Processing:Cellular processes and signaling:Metabolism of Cofactors and Vitamins:Metabolism:Poorly characterized:Information storage and processing:Metabolism:Thiamine:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function:Protein modification and repair:Protein fate:tRNA and rRNA base modification:Protein synthesis:Small molecule interactions:Regulatory functions" 83 "Site-specific DNA methylase:Lactoylglutathione lyase and related lyases:Uncharacterized membrane-associated protein:Permeases of the drug/metabolite transporter (DMT) superfamily:FOG: CheY-like receiver:Cytochrome c biogenesis protein:Uncharacterized membrane protein:SOS-response transcriptional repressors (RecA-mediated autopeptidases):Transcriptional regulators:Membrane protein involved in cytochrome C biogenesis:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Cysteine and methionine metabolism:Metabolic pathways:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:lexA:dcm:Metabolism:Amino Acid Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:DNA interactions:DNA metabolism:DNA replication, recombination, and repair:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 84 "Energy production and conversion:FAD/FMN-containing dehydrogenases:Multimeric flavodoxin WrbA:Sec-independent protein secretion pathway component TatC:Amino acid transporters:ABC-type multidrug transport system, ATPase and permease components:ABC-type antimicrobial peptide transport system, ATPase component:Cytosine/uracil/thiamine/allantoin permeases:Predicted membrane protein:Putative multicopper oxidases:Thermophilic glucose-6-phosphate isomerase and related metalloenzymes:Xanthine/uracil permeases:Sugar phosphate permease:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Glyoxylate and dicarboxylate metabolism:Metabolic pathways:Two-component system:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:ncs1:ncs2:tatC:bicupin_oxalic:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Membrane Transport:Environmental Information Processing:Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Nucleosides, purines and pyrimidines:Carbohydrate Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Metabolism:Global:Signal Transduction" 85 "Arginase/agmatinase/formimionoglutamate hydrolase, arginase family:3-oxoacyl-(acyl-carrier-protein) synthase:(acyl-carrier-protein) S-malonyltransferase:Asparagine synthase (glutamine-hydrolyzing):Non-ribosomal peptide synthetase modules and related proteins:Enoyl-CoA hydratase/carnithine racemase:Imidazolonepropionase and related amidohydrolases:Beta-fructosidases (levanase/invertase):Phosphotransferase system, mannose/fructose-specific component IIA:Histidine ammonia-lyase:Urocanate hydratase:Polyketide synthase modules and related proteins:3-hydroxy-3-methylglutaryl CoA synthase:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Fructose and mannose metabolism:Fatty acid metabolism:Synthesis and degradation of ketone bodies:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine degradation:Geraniol degradation:Lysine degradation:Histidine metabolism:Benzoate degradation:Tryptophan metabolism:beta-Alanine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Aminobenzoate degradation:Propanoate metabolism:Butanoate metabolism:Terpenoid backbone biosynthesis:Limonene and pinene degradation:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Phosphotransferase system (PTS):Secondary metabolites biosynthesis, transport and catabolism:fabD:EII-Sor:EIIA-man:EIID-AGA:pts-sorbose:hutI:hutH:hutG:hutU:asn_synth_AEB:NRPS-para261:AA-adenyl-dom:Metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Energy metabolism:Carbohydrate Metabolism:Amino acids and amines:Fatty acid and phospholipid metabolism:Biosynthesis:Amino acid biosynthesis:Aspartate family:Signal transduction:PTS" 86 "Lactoylglutathione lyase and related lyases:Predicted Na+-dependent transporter:Fucose permease:Predicted esterase of the alpha-beta hydrolase superfamily:Alkaline phosphatase:Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family:Adenosine deaminase:Arabinose efflux permease:Phage-related holin (Lysis protein):L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Ascorbate and aldarate metabolism:Purine metabolism:Aminobenzoate degradation:Folate biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:General function prediction only:NaPi_cotrn_rel:holin_tox_secr:glucar-dehydr:Cellular processes and signaling:Prophage functions:Mobile and extrachromosomal element functions:Cations and iron carrying compounds:Transport and binding proteins:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism" 87 "Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Mg2+ and Co2+ transporters:Uroporphyrinogen-III synthase:ATP-dependent DNA ligase:Coenzyme transport and metabolism:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Base excision repair:Nucleotide excision repair:Mismatch repair:Non-homologous end-joining:corA:cobA_cysG_Cterm:NHEJ_ligase_prk:DNA metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Global:Metabolism:Metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Cations and iron carrying compounds:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism" 88 "ABC-type multidrug transport system, ATPase and permease components:Uncharacterized conserved protein:DnaK suppressor protein:Predicted membrane protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Function unknown:Signal transduction mechanisms:spore_V_AC:spore_III_AC:spore_yteA:Defense mechanisms:Poorly characterized:Cellular processes and signaling:Sporulation and germination:Cellular processes" 89 "Energy production and conversion:5-formyltetrahydrofolate cyclo-ligase:Pseudouridylate synthases, 23S RNA-specific:Uncharacterized membrane-associated protein:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Signal transduction histidine kinase:Predicted permeases:Exonuclease III:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type antimicrobial peptide transport system, ATPase component:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Thymidine kinase:Purine-cytosine permease and related proteins:ABC-type Na+ efflux pump, permease component:Cytosine/uracil/thiamine/allantoin permeases:Sugar phosphate permease:ABC-type uncharacterized transport system, ATPase component:Phage-related replication protein:Signal transduction histidine kinase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:One carbon pool by folate:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Phosphotransferase system (PTS):Base excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:rluA_subfam:exoDNase_III:ncs1:EIIB_glc:yxeA_fam:hydantase:MTHFS_bact:Defense mechanisms:Signal transduction:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Central intermediary metabolism:One-carbon metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Nucleosides, purines and pyrimidines:Hypothetical proteins:Conserved:Metabolism:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 90 "Tyrosyl-tRNA synthetase:Mannitol-1-phosphate/altronate dehydrogenases:Molecular chaperone, HSP90 family:Predicted epimerase, PhzC/PhzF homolog:Alanine dehydrogenase:UDP-N-acetylmuramoylalanine-D-glutamate ligase:Non-ribosomal peptide synthetase modules and related proteins:Threonine dehydrogenase and related Zn-dependent dehydrogenases:Oligoendopeptidase F:Acyl carrier protein phosphodiesterase:Transcriptional regulators:Putative NADP-dependent oxidoreductases:Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase:Predicted thioesterase involved in non-ribosomal peptide biosynthesis:Endoglucanase C-terminal domain/subunit and related proteins:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Fructose and mannose metabolism:Alanine aspartate and glutamate metabolism:Taurine and hypotaurine metabolism:Cyanoamino acid metabolism:Starch and sucrose metabolism:Limonene and pinene degradation:Aminoacyl-tRNA biosynthesis:Biosynthesis of unsaturated fatty acids:Nonribosomal peptide structures:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:pepF:tyrS:alaDH:PhzF_family:AA-adenyl-dom:poly_gGlu_PgsC:poly_gGlu_PgsB:Information storage and processing:Other:Cell envelope:Toxin production and resistance:Cellular processes:Degradation of proteins, peptides, and glycopeptides:Protein fate:tRNA aminoacylation:Protein synthesis:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling" 91 "Energy production and conversion:N-formylmethionyl-tRNA deformylase:(acyl-carrier-protein) S-malonyltransferase:Peroxiredoxin:Thiol-disulfide isomerase and thioredoxins:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):ABC-type multidrug transport system, ATPase component:Transcriptional regulators, similar to M. xanthus CarD:Transcriptional regulators:Acetyltransferases, including N-acetylases of ribosomal proteins:Beta-lactamase class C and other penicillin binding proteins:Predicted transcriptional regulators:Aspartate racemase:Transcriptional regulators:Sugar phosphate permease:Predicted ABC-type exoprotein transport system, permease component:Uncharacterized conserved protein:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:General function prediction only:Function unknown:asp_race:pept_deformyl:fabD:SP:DNA_bind_RsfA:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Sporulation and germination:Cellular processes:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Protein modification and repair:Protein fate:Biosynthesis:Fatty acid and phospholipid metabolism:Amino acids and amines:Energy metabolism" 92 "ABC-type antimicrobial peptide transport system, permease component:Periplasmic serine proteases (ClpP class):Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type antimicrobial peptide transport system, ATPase component:Predicted membrane protein:Deoxyinosine 3'endonuclease (endonuclease V):Predicted membrane protein/domain:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Predicted membrane protein:Predicted membrane protein:Uncharacterized small protein:Uncharacterized conserved protein:Lipid transport and metabolism:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:SppA_dom:T7_EssB:T7SS_EssA_Firm:T7_esaA_Nterm:WXG100_ESAT6:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking:Protein fate:Information storage and processing:Metabolism:Poorly characterized:Cellular processes and signaling" 93 "Energy production and conversion:Thioredoxin reductase:ABC-type Fe3+-siderophore transport system, permease component:ABC-type Fe3+-hydroxamate transport system, periplasmic component:High-affinity Fe2+/Pb2+ permease:Nitroreductase:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:Predicted periplasmic lipoprotein involved in iron transport:Predicted iron-dependent peroxidase:ABC-type Fe3+-citrate transport system, periplasmic component:ABC-type enterochelin transport system, ATPase component:ABC-type enterochelin transport system, permease component:ABC-type enterochelin transport system, permease component:ABC-type enterochelin transport system, periplasmic component:Coenzyme transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:ABC transporters:tat_substr_1:Cellular processes and signaling:Membrane Transport:Environmental Information Processing:Metabolism:Nucleotide Metabolism:Metabolism" 94 "Energy production and conversion:Integral membrane protein possibly involved in chromosome condensation:Predicted transcriptional regulators:Signal peptidase I:Shikimate kinase:Cell division protein FtsI/penicillin-binding protein 2:Ferredoxin:Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains:Predicted phosphohydrolases:Uncharacterized conserved protein:Transcriptional regulators:Homoserine trans-succinylase:Dioxygenases related to 2-nitropropane dioxygenase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Cysteine and methionine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Nitrogen metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Protein export:General function prediction only:Function unknown:TIGR00244:metA:sigpep_I_bact:Intracellular trafficking, secretion, and vesicular transport:DNA interactions:Regulatory functions:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Genetic Information Processing:Amino Acid Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Aspartate family:Amino acid biosynthesis:Protein and peptide secretion and trafficking:Protein fate" 95 "Energy production and conversion:Molybdenum cofactor biosynthesis enzyme:Predicted amidohydrolase:Zn-dependent protease with chaperone function:Predicted PP-loop superfamily ATPase:Permeases of the drug/metabolite transporter (DMT) superfamily:Predicted permeases:Gamma-aminobutyrate permease and related permeases:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulators:Glycosyl transferases, related to UDP-glucuronosyltransferase:Mn2+ and Fe2+ transporters of the NRAMP family:Uncharacterized host factor I protein:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:Phenolic acid decarboxylase:Uncharacterized small protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:RNA degradation:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00364:moaC:nramp:MGT:Hfq:oxido_grp_1:Cellular processes:Cations and iron carrying compounds:Transport and binding proteins:Other:Regulatory functions:Cellular processes and signaling:Folding Sorting and Degradation:Metabolism:Poorly characterized:Information storage and processing:Molybdopterin:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Enzymes of unknown specificity:Unknown function:Genetic Information Processing:Toxin production and resistance" 96 "Polyprenyltransferase (cytochrome oxidase assembly factor):Glycosyltransferase:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Permeases of the drug/metabolite transporter (DMT) superfamily:Predicted xylanase/chitin deacetylase:Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake:Methyl-accepting chemotaxis protein:Gamma-aminobutyrate permease and related permeases:Uncharacterized conserved protein:Putative effector of murein hydrolase:Putative effector of murein hydrolase LrgA:Predicted membrane protein/domain:ATP-dependent DNA ligase:Sulfite oxidase and related enzymes:Uncharacterized vancomycin resistance protein:Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis:Predicted Zn peptidase:Uncharacterized protein conserved in bacteria:Predicted permease, DMT superfamily:Spore coat protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Base excision repair:Nucleotide excision repair:Mismatch repair:Non-homologous end-joining:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:dprA:2A0309:cyoE_ctaB:Ku_bact:NHEJ_ligase_prk:spore_ger_x_C:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Information storage and processing:Energy Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Amino acids, peptides and amines:Cellular processes:DNA transformation:Sporulation and germination:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 97 "tRNA-dihydrouridine synthase:Riboflavin synthase beta-chain:3,4-dihydroxy-2-butanone 4-phosphate synthase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Anthranilate/para-aminobenzoate synthases component I:Protein chain release factor A:Dihydropteroate synthase and related enzymes:Cytidine deaminase:Riboflavin synthase alpha chain:Anthranilate/para-aminobenzoate synthases component II:Topoisomerase IA:ATPase involved in DNA replication initiation:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase:GTPase:Lysyl-tRNA synthetase (class II):Transcriptional regulator:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:Recombinational DNA repair protein (RecF pathway):Dihydroneopterin aldolase:Uncharacterized conserved protein:Transcriptional regulators:Pyrimidine reductase, riboflavin biosynthesis:DNA polymerase III, gamma/tau subunits:Signal transduction histidine kinase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Purine metabolism:Pyrimidine metabolism:Riboflavin metabolism:Folate biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Two-component system:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:prfB:lumazine-synth:ribE:ribD_Cterm:small_GTP:IMPACT_YIGZ:lytR_cpsA_psr:DnaA:lysS_bact:ribA:folB:trpG_papA:reco:nifR3_yhdG:topB:cyt_deam_tetra:DHPS:folK:dnaX_nterm:Salvage of nucleosides and nucleotides:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Replication and Repair:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Translation factors:Nucleotide Metabolism:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Riboflavin, FMN, and FAD:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:tRNA aminoacylation:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Other:Regulatory functions" 98 "Predicted GTPase, probable translation factor:Nucleotide-binding protein implicated in inhibition of septum formation:RecA/RadA recombinase:Predicted membrane metal-binding protein:Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Non-ribosomal peptide synthetase modules and related proteins:Predicted amidophosphoribosyltransferases:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:DNA segregation ATPase FtsK/SpoIIIE and related proteins:Type II secretory pathway, prepilin signal peptidase PulO and related peptidases:DNA repair proteins:Deoxycytidylate deaminase:Signal transduction histidine kinase:Genetic competence transcription factor:Predicted permease, DMT superfamily:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Starch and sucrose metabolism:Metabolic pathways:Phosphotransferase system (PTS):Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:TIGR00092:maf:comF:ComEC_N-term:radc:dprA:2A78:HEQRo_perm_3TM:AA-adenyl-dom:PTS-II-BC-sucr:tigrfam_recA:ComEB:Intracellular trafficking, secretion, and vesicular transport:General:Carbohydrate Metabolism:Nucleotide Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Amino acids, peptides and amines:Cellular processes:Cell division:DNA transformation:Unknown function:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 99 "Glycosyltransferase:Nucleoside-diphosphate-sugar epimerases:Adenylylsulfate kinase and related kinases:Predicted UDP-glucose 6-dehydrogenase:UDP-glucose pyrophosphorylase:ATP sulfurylase (sulfate adenylyltransferase):Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Galactose metabolism:Ascorbate and aldarate metabolism:Purine metabolism:Selenocompound metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:sopT:apsK:spore_dpaB:spore_dpaA:NDP-sugDHase:Cellular processes:Sporulation and germination:Cellular processes and signaling:Metabolism:Sulfur metabolism:Central intermediary metabolism:Metabolism:Metabolism:Global:Metabolism of Other Amino Acids:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism" 100 "Single-stranded DNA-binding protein:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Type II secretory pathway, component PulF:DNA uptake protein and related DNA-binding proteins:Type II secretory pathway, pseudopilin PulG:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein):Competence protein:Competence protein ComGC:Competence protein ComGF:Transcription:Replication, recombination and repair:Cell motility:General function prediction only:Signal transduction mechanisms:TIGR00426:ssb:IV_pilin_GFxxxE:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:DNA transformation:Cellular processes:Poorly characterized:Protein fate:DNA replication, recombination, and repair:DNA metabolism:Protein and peptide secretion and trafficking:Cellular processes and signaling" 101 "Energy production and conversion:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Nitrogen regulatory protein PII:Urea amidohydrolase (urease) alpha subunit:Urea amidohydrolase (urease) gamma subunit:Urea amidohydrolase (urease) beta subunit:Cellulase M and related proteins:Subtilisin-like serine proteases:Metal-dependent amidase/aminoacylase/carboxypeptidase:2'-5' RNA ligase:Acetyltransferases, including N-acetylases of ribosomal proteins:Glycosyl transferases, related to UDP-glucuronosyltransferase:Transcriptional regulators:Cytochrome P450:Predicted acyltransferase:Predicted aminopeptidases:Uncharacterized protein conserved in bacteria:Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides:Enterochelin esterase and related enzymes:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Lysine degradation:Arginine and proline metabolism:Phenylalanine metabolism:Bisphenol degradation:D-Arginine and D-ornithine metabolism:D-Alanine metabolism:Polycyclic aromatic hydrocarbon degradation:Aminobenzoate degradation:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:urease_beta:urease_gam:D_amino_aminoT:MGT:urease_alph:amidohydrolases:Energy metabolism:Nitrogen metabolism:Central intermediary metabolism:Metabolism:Global:Metabolism:Signal Transduction:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Poorly characterized:Nucleotide Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Toxin production and resistance:Cellular processes:Degradation of proteins, peptides, and glycopeptides:Protein fate:Amino acids and amines" 102 "Energy production and conversion:Arginyl-tRNA synthetase:Ribonucleotide reductase, beta subunit:Lactoylglutathione lyase and related lyases:Citrate synthase:UDP-N-acetylglucosamine 2-epimerase:Superfamily II DNA helicase:Glycine/D-amino acid oxidases (deaminating):Membrane carboxypeptidase (penicillin-binding protein):Periplasmic protease:ABC-type multidrug transport system, ATPase and permease components:Threonine dehydratase:Metal-dependent hydrolases of the beta-lactamase superfamily III:Methylase of chemotaxis methyl-accepting proteins:Predicted transcriptional regulators:Acyl dehydratase:Formate/nitrite family of transporters:Predicted permeases:Amino acid transport and metabolism:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine biosynthesis:Amino sugar and nucleotide sugar metabolism:Glyoxylate and dicarboxylate metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:RNA degradation:General function prediction only:Signal transduction mechanisms:prc:wecB:argS:recQ_fam:rarD:fnt:THD1:RNase_Z:Defense mechanisms:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:RNA processing:Protein synthesis:tRNA aminoacylation:Protein fate:Protein modification and repair:Transport and binding proteins:Unknown substrate:Anions:Amino acid biosynthesis:Pyruvate family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 103 "Ribosomal protein S2:Ribosomal protein L11:Ribosomal protein L1:Ribosomal protein L13:Ribosomal protein S9:Ribosomal protein L27:Ribosomal protein S18:Ribosomal protein L21:Translation initiation factor 3 (IF-3):Ribosomal protein L35:Ribosomal protein L20:Ribosomal protein L32:Single-stranded DNA-binding protein:Predicted ribosomal protein:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Ribosome:DNA replication:Mismatch repair:Homologous recombination:rpmI_bact:L21:L27:S18:infC:ssb:rpsB_bact:rpmF_bact:rplT_bact:rplM_bact:rplA_bact:L11_bact:Information storage and processing:Translation:Translation factors:Ribosomal proteins: synthesis and modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Genetic Information Processing:Replication and Repair" 104 "Ribosomal protein S7:Ribosomal protein S2:Ribosomal protein L11:Ribosomal protein L1:Ribosomal protein L7/L12:Ribosome recycling factor:Ribosomal protein L10:Translation elongation factor Ts:Uridylate kinase:FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor):Actin-like ATPase involved in cell morphogenesis:Ribosomal protein HS6-type (S12/L30/L7a):Cell shape-determining protein:Cell shape-determining protein:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Metabolic pathways:Ribosome:tig:tsf:mreC:frr:L12:mreB:rpsB_bact:rpsG_bact:rplA_bact:L11_bact:pyrH_bact:shape_MreD:Metabolism:Nucleotide Metabolism:Genetic Information Processing:Translation:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Protein synthesis:Ribosomal proteins: synthesis and modification:Translation factors:Protein fate:Protein folding and stabilization:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism" 105 "Nucleoside diphosphate kinase:Carbonic anhydrase:Signal transduction histidine kinase:Nucleotide transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Signal transduction mechanisms:Metabolism:Energy Metabolism:Nucleotide Metabolism:Environmental Information Processing:Signal Transduction:Global:Metabolism:Cellular processes and signaling:Metabolism" 106 "Energy production and conversion:Pentose-5-phosphate-3-epimerase:F0F1-type ATP synthase, beta subunit:F0F1-type ATP synthase, alpha subunit:Acetyltransferase (isoleucine patch superfamily):Pseudouridine synthase:F0F1-type ATP synthase, gamma subunit:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit):F0F1-type ATP synthase, subunit a:Serine/threonine protein kinase:Aspartokinases:Predicted phosphatases:Serine/threonine protein phosphatase:Prolipoprotein diacylglyceryltransferase:F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein):Predicted GTPases:Serine kinase of the HPr protein, regulates carbohydrate metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Pentose phosphate pathway:Pentose and glucuronate interconversions:Oxidative phosphorylation:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Signal transduction mechanisms:TIGR00157:TruB:lgt:asp_kin_monofn:dapA:hpr-ser:atpA:atpD:ATP_synt_6_or_A:ATP_synt_delta:ATPsyn_F1gamma:rpe:ATP_synt_epsi:ATP_synt_c:HAD-SF-IA-v3:Protein fate:Translation factors:tRNA and rRNA base modification:Protein synthesis:Pentose phosphate pathway:ATP-proton motive force interconversion:Energy metabolism:Metabolism:Metabolism:Global:Amino Acid Metabolism:Energy Metabolism:Enzymes of unknown specificity:Carbohydrate Metabolism:Amino acid biosynthesis:Aspartate family:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Unknown function:Protein modification and repair" 107 "Energy production and conversion:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Chorismate synthase:Tryptophan synthase beta chain:Indole-3-glycerol phosphate synthase:Phosphoribosylanthranilate isomerase:Anthranilate/para-aminobenzoate synthases component I:Tryptophan synthase alpha chain:Prephenate dehydrogenase:3-dehydroquinate synthetase:Anthranilate phosphoribosyltransferase:Nitroreductase:ABC-type metal ion transport system, periplasmic component/surface adhesin:Heme/copper-type cytochrome/quinol oxidases, subunit 1:ABC-type Mn2+/Zn2+ transport systems, permease components:ABC-type Mn/Zn transport systems, ATPase component:Heme/copper-type cytochrome/quinol oxidases, subunit 2:Protein-disulfide isomerase:Heme/copper-type cytochrome/quinol oxidase, subunit 3:HD-GYP domain:Heme/copper-type cytochrome/quinol oxidase, subunit 4:Chorismate mutase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Glycine serine and threonine metabolism:Histidine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Signal transduction mechanisms:aroC:trpA:trpB:HDIG:trpE_most:hisC:trpD:aroB:QOXA:CM_mono_aroH:QoxB:QoxC:QoxD:Energy Metabolism:Histidine family:Cellular processes and signaling:Metabolism:Amino acid biosynthesis:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Biosynthesis of Other Secondary Metabolites:Amino Acid Metabolism:Aromatic amino acid family" 108 "Membrane carboxypeptidase (penicillin-binding protein):Uncharacterized conserved protein:Putative NADH-flavin reductase:Uncharacterized conserved protein:Cell wall/membrane/envelope biogenesis:General function prediction only:Function unknown:PBP_1a_fam:Poorly characterized:Cellular processes and signaling:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope" 109 "Dihydrofolate reductase:Uncharacterized conserved protein:Transcriptional regulator:Hemolysins and related proteins containing CBS domains:Small primase-like proteins (Toprim domain):Predicted transcriptional regulators:Transcriptional regulators:Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family:Predicted Zn-dependent protease:Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis:Uncharacterized conserved protein:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00049:Poorly characterized:Metabolism:Information storage and processing:Other:Biosynthesis of cofactors, prosthetic groups, and carriers" 110 "Replicative DNA helicase:DNA polymerase III, alpha subunit:Single-stranded DNA-specific exonuclease:ATP-dependent DNA ligase:Uncharacterized protein conserved in bacteria:Replication, recombination and repair:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:Homologous recombination:Non-homologous end-joining:Function unknown:polc:recJ:Genetic Information Processing:Nucleotide Metabolism:Global:Metabolism:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Information storage and processing:Poorly characterized:Replication and Repair" 111 "Energy production and conversion:Dihydroxyacid dehydratase/phosphogluconate dehydratase:Lactoylglutathione lyase and related lyases:Predicted esterase:ATPase components of ABC transporters with duplicated ATPase domains:Cytosine/adenosine deaminases:NAD-dependent aldehyde dehydrogenases:Hydrolases of the alpha/beta superfamily:Transcriptional regulator:Predicted nucleotidyltransferase:Uncharacterized low-complexity proteins:Transcriptional regulators:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:Membrane transporters of cations and cationic drugs:Cation transport ATPase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Fatty acid metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Benzoate degradation:Tryptophan metabolism:beta-Alanine metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Propanoate metabolism:Pantothenate and CoA biosynthesis:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA polymerase:General function prediction only:Function unknown:taut:ilvD:ATPase_P-type:sigma70-ECF:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Energy metabolism:Other:Amino acid biosynthesis:Pyruvate family:Information storage and processing:Metabolism:Poorly characterized:Metabolism:Global:Transcription:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Metabolism" 112 "Aspartate oxidase:Ribosomal protein S7:Ribosomal protein S10:Ribosomal protein L3:Ribosomal protein L4:Ribosomal protein L23:Ribosomal protein L2:Ribosomal protein L22:Nicotinate-nucleotide pyrophosphorylase:Ribosomal protein S19:Quinolinate synthase:Threonyl-tRNA synthetase:Translation elongation factors (GTPases):FOG: LysM repeat:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Alanine aspartate and glutamate metabolism:Nicotinate and nicotinamide metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Ribosome:nadC:small_GTP:thrS:nadA:nadB:rpsG_bact:rplV_bact:rpsJ_bact:rpsS_bact:rplB_bact:spore_safA:L3_bact:rplD_bact:Pyridine nucleotides:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Global:Metabolism:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Cellular processes:Sporulation and germination:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism" 113 "Energy production and conversion:Lipoate-protein ligase A:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase:ATPases involved in chromosome partitioning:Predicted phosphatase/phosphohexomutase:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Hydrolases of the alpha/beta superfamily:Phosphomannomutase:ABC-type multidrug transport system, ATPase and permease components:Metal-dependent hydrolases of the beta-lactamase superfamily III:Arsenate reductase and related proteins, glutaredoxin family:Predicted esterase of the alpha-beta hydrolase superfamily:Di- and tripeptidases:Leucyl aminopeptidase (aminopeptidase T):Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides:3-carboxymuconate cyclase:Uncharacterized protein conserved in bacteria:Exopolysaccharide biosynthesis protein:Uncharacterized conserved protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Galactose metabolism:Purine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Lipoic acid metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:ispF:lipoyltrans:HAD-SF-IA-v3:arsC_related:peptidase-T:thiol_BshC:Defense mechanisms:Degradation of proteins, peptides, and glycopeptides:Protein fate:DNA interactions:Regulatory functions:Metabolism:Global:Metabolism:Signal Transduction:Environmental Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Cellular processes and signaling:Carbohydrate Metabolism:Metabolism:Poorly characterized:Glutathione and analogs:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function:Protein modification and repair" 114 "Energy production and conversion:3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase:Predicted transcriptional regulators:Monoamine oxidase:Transcriptional regulator:Subtilisin-like serine proteases:Acetyltransferases, including N-acetylases of ribosomal proteins:Glycosyl transferases, related to UDP-glucuronosyltransferase:Cytochrome P450:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:FOG: GAF domain:AraC-type DNA-binding domain-containing proteins:Uncharacterized protein conserved in bacteria:Endonuclease I:Transcriptional antiterminator:Sortase (surface protein transpeptidase):Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Bisphenol degradation:Polycyclic aromatic hydrocarbon degradation:Aminobenzoate degradation:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:Signal transduction mechanisms:sortase_fam:MGT:expor_sig_YdyF:Regulatory functions:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Poorly characterized:Metabolism of Terpenoids and Polyketides:Metabolism:Cellular processes and signaling:Information storage and processing:Toxin production and resistance:Cellular processes:Protein and peptide secretion and trafficking:Protein fate:Protein interactions" 115 "3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase:Integral membrane protein possibly involved in chromosome condensation:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Predicted transcriptional regulators:Putative intracellular protease/amidase:Shikimate kinase:Uncharacterized membrane protein (homolog of Drosophila rhomboid):Uncharacterized conserved protein:Membrane protein TerC, possibly involved in tellurium resistance:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Predicted phosphohydrolases:Transcriptional regulators:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:Na+/melibiose symporter and related transporters:Arabinose efflux permease:Uncharacterized protein conserved in bacteria:Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Transcriptional regulator, effector-binding domain/component:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Arginine and proline metabolism:Benzoate degradation:Phenylalanine tyrosine and tryptophan biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Base excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:taut:TIGR00278:crcB:2_A_01_02:R_switched_YjbE:Other:Energy metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism:Replication and Repair:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Poorly characterized:Amino Acid Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:General:Unknown function:Conserved:Hypothetical proteins" 116 "Lipoate synthase:DNA mismatch repair enzyme (predicted ATPase):Predicted hydrolases of the HAD superfamily:Predicted transcriptional regulators:Na+-dependent transporters of the SNF family:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Panthothenate kinase:Predicted SAM-dependent methyltransferases:Uncharacterized conserved protein:Uncharacterized low-complexity proteins:DNA segregation ATPase FtsK/SpoIIIE and related proteins:Predicted RNA-binding protein (contains KH domain):Uncharacterized bacitracin resistance protein:Transcriptional regulators:Uncharacterized protein conserved in bacteria:Predicted ATPase involved in cell division:Predicted membrane protein:Cell wall hydrolyses involved in spore germination:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Predicted glycosyltransferase:Cell cycle control, cell division, chromosome partitioning:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Fatty acid biosynthesis:Purine metabolism:Peptidoglycan biosynthesis:Pantothenate and CoA biosynthesis:Lipoic acid metabolism:Metabolic pathways:ABC transporters:Mismatch repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Cof-subfamily:lipA:panK_bact:mutl:undec_PP_bacA:FtsE:Defense mechanisms:Biosynthesis and degradation of murein sacculus and peptidoglycan:Lipid Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Cellular processes:Cell division:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Lipoate:Pantothenate and coenzyme A:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 117 "ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID:Carbohydrate transport and metabolism:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Phosphotransferase system (PTS):EII-Sor:EIID-AGA:pts-sorbose:Signal transduction:PTS:Metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Carbohydrate Metabolism" 118 "Micrococcal nuclease (thermonuclease) homologs:Acetyltransferases, including N-acetylases of ribosomal proteins:Site-specific recombinases, DNA invertase Pin homologs:Aminoglycoside N3'-acetyltransferase:DNA gyrase inhibitor:Uncharacterized conserved protein:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Function unknown:Defense mechanisms:Information storage and processing:Poorly characterized:Cellular processes and signaling" 119 "Energy production and conversion:Ribosomal protein S12:Lipoate-protein ligase A:Ribosomal protein L13:Ribosomal protein S15P/S13E:Ribosomal protein L28:Ribosomal protein L31:Phosphate/sulphate permeases:Ribosomal protein L19:Ribosomal protein S6:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Ribosomal protein S4 and related proteins:Rhodanese-related sulfurtransferase:Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Predicted RNA binding protein (contains ribosomal protein S1 domain):NADH dehydrogenase, FAD-containing subunit:Phosphate transport regulator (distant homolog of PhoU):Phosphotransferase system, HPr-related proteins:Uncharacterized conserved protein:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Lipoic acid metabolism:Metabolic pathways:Phosphotransferase system (PTS):Ribosome:Function unknown:L28:L31:S6:S15_bact:rpsL_bact:PTS_HPr_family:rpsD_bact:rplS_bact:rpmH_bact:rplM_bact:apt:PTS_I_fam:PTS:Signal transduction:Ribosomal proteins: synthesis and modification:Protein synthesis:Salvage of nucleosides and nucleotides:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Information storage and processing" 120 "Arabinose efflux permease:ABC-type polysaccharide transport system, permease component:Uncharacterized conserved protein:Carbohydrate transport and metabolism:Function unknown:Metabolism:Poorly characterized" 121 "Actin-like ATPase involved in cell morphogenesis:Transcriptional regulators:Uncharacterized protein with SCP/PR1 domains:Lysophospholipase L1 and related esterases:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Transcription:Function unknown:mreB:spore_YkwD:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope:Poorly characterized" 122 "Geranylgeranyl pyrophosphate synthase:Transcription elongation factor:DnaJ-class molecular chaperone with C-terminal Zn finger domain:Translation initiation factor 2 (IF-2; GTPase):2-methylthioadenine synthetase:Collagenase and related proteases:Ribosome-binding factor A:ABC-type cobalt transport system, ATPase component:Ribosomal protein HS6-type (S12/L30/L7a):Uncharacterized protein conserved in bacteria:Exonuclease VII small subunit:Ribosomal protein L11 methylase:Predicted nucleic-acid-binding protein implicated in transcription termination:Predicted O-methyltransferase:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Mismatch repair:General function prediction only:Function unknown:TIGR00046:rbfA:TIGR00089:small_GTP:prmA:xseB:NusA:DnaJ_bact:tRNA and rRNA base modification:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:Degradation of DNA:Transcription:Transcription factors:RNA processing:Protein synthesis:Ribosomal proteins: synthesis and modification:Metabolism:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 123 "Energy production and conversion:NhaP-type Na+/H+ and K+/H+ antiporters:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Ribosomal protein S14:Uncharacterized conserved protein:Kef-type K+ transport systems, membrane components:ATPase components of ABC transporters with duplicated ATPase domains:Thiol-disulfide isomerase and thioredoxins:Cytosine/adenosine deaminases:Methionine synthase II (cobalamin-independent):Signal peptidase I:Uncharacterized membrane protein (homolog of Drosophila rhomboid):Nitroreductase:Predicted transcriptional regulators:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:ABC-type multidrug transport system, ATPase and permease components:Uncharacterized conserved protein:Predicted nucleotidyltransferase:Transcriptional regulators:Ketopantoate reductase:Predicted membrane protein:Arabinose efflux permease:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Thiamine metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:Protein export:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:apbA_panE:a_cpa1:ilvE_II:sigpep_I_bact:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Pantothenate and coenzyme A:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyruvate family:Amino acid biosynthesis:Cations and iron carrying compounds:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Metabolism:Global:Folding Sorting and Degradation:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism" 124 "Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Predicted membrane protein:Outer membrane lipoprotein-sorting protein:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Uncharacterized small protein:Uncharacterized conserved protein:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:T7_EssB:T7SS_EssA_Firm:T7_esaA_Nterm:Metabolism:Cellular processes and signaling:Protein and peptide secretion and trafficking:Protein fate:Poorly characterized" 125 "Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family:tRNA-(guanine-N1)-methyltransferase:Superfamily II DNA and RNA helicases:Signal recognition particle GTPase:ABC-type antimicrobial peptide transport system, permease component:RimM protein, required for 16S rRNA processing:Membrane-fusion protein:ABC-type antimicrobial peptide transport system, ATPase component:Subtilisin-like serine proteases:Lysophospholipase L1 and related esterases:Rhs family protein:Predicted kinase:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Cysteine and methionine metabolism:Metabolic pathways:ABC transporters:Protein export:Bacterial secretion system:General function prediction only:ftsY:trmD:salvage_mtnA:YD_repeat_2x:MTRK:16S_RimM:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Aspartate family:Amino Acid Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transcription:RNA processing:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Amino acid biosynthesis:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 126 "Glucan phosphorylase:Glycogen synthase:Glycosidases:ADP-glucose pyrophosphorylase:Predicted hydrolases of the HAD superfamily:Superoxide dismutase:Cell division protein FtsI/penicillin-binding protein 2:ABC-type polar amino acid transport system, ATPase component:Squalene cyclase:D-alanyl-D-alanine carboxypeptidase:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Galactose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:Function unknown:Cof-subfamily:squalene_cyclas:glgC:glgD:P_ylase:glgA:spoVD_pbp:spore_III_AB:spore_II_P:spore_yhbH:DNA_bind_RsfA:Cellular processes and signaling:Enzymes of unknown specificity:Unknown function:Sporulation and germination:Cellular processes:Biosynthesis and degradation of polysaccharides:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Glycan Biosynthesis and Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism" 127 "Energy production and conversion:Pyrroline-5-carboxylate reductase:Asparagine synthase (glutamine-hydrolyzing):Aspartate/tyrosine/aromatic aminotransferase:Biotin carboxylase:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Predicted permeases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Cytochrome bd-type quinol oxidase, subunit 1:Membrane protein involved in the export of O-antigen and teichoic acid:Uncharacterized vancomycin resistance protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Lipid transport and metabolism:Inorganic ion transport and metabolism:Oxidative phosphorylation:Alanine aspartate and glutamate metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:2A0309:asn_synth_AEB:spore_ger_x_C:spore_V_B:spore_yutH:TIGR03833:Defense mechanisms:Poorly characterized:Energy Metabolism:Amino Acid Metabolism:Genetic Information Processing:Transcription:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transport and binding proteins:Amino acids, peptides and amines:Cellular processes:Sporulation and germination:Hypothetical proteins:Conserved:Amino acid biosynthesis:Aspartate family:Cellular processes and signaling:Metabolism:Metabolism" 128 "Energy production and conversion:Transketolase:Phosphoglycerate dehydrogenase and related dehydrogenases:Glycine/serine hydroxymethyltransferase:Thymidylate synthase:Putative translation initiation inhibitor, yjgF family:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Ribosomal protein S20:Lipoate synthase:Predicted hydrolases of the HAD superfamily:Exopolyphosphatase-related proteins:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:3-dehydroquinate dehydratase:Molybdopterin-guanine dinucleotide biosynthesis protein A:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:Bacterial nucleoid DNA-binding protein:Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Uncharacterized conserved protein:ABC-type metal ion transport system, periplasmic component/surface antigen:Metal-dependent amidase/aminoacylase/carboxypeptidase:Molybdopterin converting factor, small subunit:Cell division protein:Zn-dependent carboxypeptidase:Uncharacterized protein conserved in bacteria:Site-specific recombinase XerD:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Pentose phosphate pathway:Fatty acid biosynthesis:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine degradation:Lysine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Selenocompound metabolism:Cyanoamino acid metabolism:Pyruvate metabolism:One carbon pool by folate:Methane metabolism:Lipoic acid metabolism:Nitrogen metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Ribosome:Sulfur relay system:General function prediction only:Function unknown:TIGR00004:S20:Cof-subfamily:tktlase_bact:lipA:aroD:PGDH:lipoamide_DH:moaD:fabZ:amidohydrolases:recomb_XerD:thym_sym:Lipoate:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Pentose phosphate pathway:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Degradation of proteins, peptides, and glycopeptides:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aromatic amino acid family:Serine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Molybdopterin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 129 "Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Signal transduction histidine kinase:Predicted permeases:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Subtilisin-like serine proteases:Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases:Predicted membrane protein:Predicted membrane protein:Predicted membrane protein:3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase):Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Arginine and proline metabolism:Inositol phosphate metabolism:Metabolic pathways:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:2a69:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Transport and binding proteins:Metabolism:Global:Amino Acid Metabolism:Metabolism:Carbohydrate Metabolism" 130 "Energy production and conversion:Anaerobic dehydrogenases, typically selenocysteine-containing:L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D:Glycosyltransferases involved in cell wall biogenesis:Gamma-aminobutyrate permease and related permeases:Phosphotransferase system cellobiose-specific component IIC:Beta-fructosidases (levanase/invertase):Uncharacterized protein containing LysM domain:ABC-type Na+ efflux pump, permease component:Nitrate/nitrite transporter:Sugar phosphate permease:Response regulator of the LytR/AlgR family:Signal transduction histidine kinase regulating citrate/malate metabolism:Uncharacterized homolog of phage Mu protein gp47:Recombinational DNA repair protein (RecE pathway):ABC-type uncharacterized transport system, periplasmic component:ABC-type Na+ transport system, ATPase component:Phage-related minor tail protein:Phage-related protein, predicted endonuclease:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Cyanoamino acid metabolism:Starch and sucrose metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Phosphotransferase system (PTS):General function prediction only:Function unknown:Signal transduction mechanisms:cello_pts_IIC:asnASE_II:rect:2A0108:phage_rel_nuc:Information storage and processing:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Energy metabolism:Amino acids and amines:Transport and binding proteins:Anions:Mobile and extrachromosomal element functions:Prophage functions:Signal transduction:PTS:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 131 "Energy production and conversion:Acetyl-CoA acetyltransferase:Fe-S oxidoreductase:Zn-dependent hydrolases, including glyoxylases:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Adenine deaminase:Enoyl-CoA hydratase/carnithine racemase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):DNA-directed RNA polymerase specialized sigma subunit:3-hydroxyacyl-CoA dehydrogenase:Transcriptional regulator:Acyl-CoA dehydrogenases:Cytochrome c, mono- and diheme variants:Electron transfer flavoprotein, alpha subunit:Electron transfer flavoprotein, beta subunit:Serine phosphatase RsbU, regulator of sigma subunit:Uncharacterized protein containing a von Willebrand factor type A (vWA) domain:H+/citrate symporter:Signal transduction histidine kinase:Nucleotide transport and metabolism:Lipid transport and metabolism:Transcription:Fatty acid metabolism:Purine metabolism:Valine leucine and isoleucine degradation:Geraniol degradation:Benzoate degradation:alpha-Linolenic acid metabolism:Naphthalene degradation:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:sensory_box:citMHS:AcCoA-C-Actrans:spore_sigG:spore_II_E:Poorly characterized:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Transcription:Environmental Information Processing:Signal Transduction:Global:Metabolism:Fatty acid and phospholipid metabolism:Other:Regulatory functions:Small molecule interactions:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cellular processes:Sporulation and germination:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 132 "Predicted Co/Zn/Cd cation transporters:Predicted S-adenosylmethionine-dependent methyltransferase:ABC-type uncharacterized transport system, permease component:Aspartate/tyrosine/aromatic aminotransferase:rRNA methylases:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):ABC-type phosphate transport system, ATPase component:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase:Transcriptional regulator:Putative effector of murein hydrolase LrgA:Disulfide bond formation protein DsbB:Predicted transcriptional regulators:Transcriptional regulators:Serine phosphatase RsbU, regulator of sigma subunit:Predicted membrane protein:Predicted membrane protein:Predicted membrane protein:Signal transduction histidine kinase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00091:menD:sensory_box:TIGR00245:CDF:menH_SHCHC:Protein synthesis:Small molecule interactions:Regulatory functions:Metabolism:Global:Cellular processes and signaling:Metabolism of Cofactors and Vitamins:Metabolism:Poorly characterized:Information storage and processing:Menaquinone and ubiquinone:Biosynthesis of cofactors, prosthetic groups, and carriers:Conserved:Hypothetical proteins:Metabolism:Cations and iron carrying compounds:Transport and binding proteins:tRNA and rRNA base modification" 133 "Energy production and conversion:ABC-type sugar transport system, permease component:Zn-dependent hydrolases, including glyoxylases:Sugar kinases, ribokinase family:Predicted dehydrogenases and related proteins:Enoyl-CoA hydratase/carnithine racemase:ABC-type sugar transport system, ATPase component:Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components:ABC-type sugar transport systems, permease components:Transcriptional regulators:ABC-type sugar transport system, periplasmic component:ABC-type ribose transport system, auxiliary component:ABC-type sugar transport system, periplasmic component:Carbon starvation protein, predicted membrane protein:H+/citrate symporter:Alpha-L-arabinofuranosidase:ABC-type sugar transport systems, ATPase components:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Pentose phosphate pathway:Fatty acid metabolism:Valine leucine and isoleucine degradation:Geraniol degradation:Lysine degradation:Benzoate degradation:Tryptophan metabolism:beta-Alanine metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Inositol phosphate metabolism:Aminobenzoate degradation:Propanoate metabolism:Butanoate metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Bacterial chemotaxis:General function prediction only:Signal transduction mechanisms:citMHS:D_ribokin_bact:SASP_H:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Biosynthesis of Other Secondary Metabolites:Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Energy metabolism:Sugars:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cellular processes:Sporulation and germination:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 134 "Energy production and conversion:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit:Phosphotransacetylase:Glutamate dehydrogenase/leucine dehydrogenase:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Uncharacterized proteins, homologs of microcin C7 resistance protein MccF:D-aminopeptidase:Butyrate kinase:ABC-type oligopeptide transport system, periplasmic component:L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily:Amino acid transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Pyruvate metabolism:Propanoate metabolism:Butanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:lipoamide_DH:oligo_HPY:P_butyryltrans:butyr_kinase:Defense mechanisms:Energy Metabolism:Metabolism:Transport and binding proteins:Carbohydrate Metabolism:Amino acids, peptides and amines:Cellular processes and signaling:Metabolism:Poorly characterized:Fermentation:Energy metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Amino Acid Metabolism" 135 "Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase):Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:tRNA delta(2)-isopentenylpyrophosphate transferase:ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member:Superfamily II DNA and RNA helicases:Metal-dependent proteases with possible chaperone activity:Predicted hydrolase of the metallo-beta-lactamase superfamily:dUTPase:ABC-type multidrug transport system, ATPase component:Inactive homolog of metal-dependent proteases, putative molecular chaperone:GTPase subunit of restriction endonuclease:Phytoene/squalene synthetase:Uncharacterized protein conserved in bacteria:GTPases:Uncharacterized conserved protein:Cystathionine beta-lyase family protein involved in aluminum resistance:Nitric oxide synthase, oxygenase domain:Amino acid transport and metabolism:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Arginine and proline metabolism:One carbon pool by folate:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:RNA degradation:Homologous recombination:General function prediction only:Function unknown:miaA:gcp_kae1:MG423:parE_Gpos:parC_Gpos:purT:recD_rel:GTP_HflX:bact_YeaZ:Defense mechanisms:Metabolism:Cellular processes and signaling:Information storage and processing:General:Enzymes of unknown specificity:Unknown function:Conserved:Hypothetical proteins:Degradation of proteins, peptides, and glycopeptides:Protein fate:tRNA and rRNA base modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Poorly characterized:Nucleotide Metabolism" 136 "Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Urea amidohydrolase (urease) alpha subunit:Urea amidohydrolase (urease) gamma subunit:Urea amidohydrolase (urease) beta subunit:Threonine dehydrogenase and related Zn-dependent dehydrogenases:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Metal-dependent amidase/aminoacylase/carboxypeptidase:Uncharacterized proteins, homologs of microcin C7 resistance protein MccF:Galactose mutarotase and related enzymes:D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4):D-aminopeptidase:Beta-xylosidase:ABC-type oligopeptide transport system, periplasmic component:L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Lysine degradation:Arginine and proline metabolism:Phenylalanine metabolism:D-Arginine and D-ornithine metabolism:D-Alanine metabolism:Peptidoglycan biosynthesis:Chloroalkane and chloroalkene degradation:Methane metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:urease_beta:urease_gam:PBP4:D_amino_aminoT:oligo_HPY:urease_alph:amidohydrolases:fdhA_non_GSH:Defense mechanisms:Cellular processes and signaling:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:One-carbon metabolism:Nitrogen metabolism:Energy metabolism:Amino acids and amines:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Amino acids, peptides and amines:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Metabolism:Metabolism:Poorly characterized" 137 "Energy production and conversion:Short-chain dehydrogenases of various substrate specificities:Di- and tricarboxylate transporters:Serine/threonine protein kinase:Universal stress protein UspA and related nucleotide-binding proteins:Cytosine/adenosine deaminases:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):NAD-dependent aldehyde dehydrogenases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type proline/glycine betaine transport systems, permease component:Hemolysins and related proteins containing CBS domains:Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein):Uncharacterized conserved protein:Arabinose efflux permease:Predicted Zn-dependent protease:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Fatty acid metabolism:Purine metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Propanoate metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:dass:SP:Transport and binding proteins:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Metabolism:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 138 "Energy production and conversion:Ribosomal protein L10:Aspartate/tyrosine/aromatic aminotransferase:Hypoxanthine-guanine phosphoribosyltransferase:F0F1-type ATP synthase, subunit b:ABC-type molybdate transport system, periplasmic component:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Predicted transcriptional regulator containing the HTH domain:ABC-type metal ion transport system, periplasmic component/surface antigen:Predicted secreted protein containing a PDZ domain:Predicted oxidoreductase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Lysine biosynthesis:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Phosphotransferase system (PTS):Ribosome:General function prediction only:Signal transduction mechanisms:TIGR00281:EIIB_glc:ATP_synt_b:HGPRTase:modA:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:DNA metabolism:Chromosome-associated proteins:Transport and binding proteins:Anions:Signal transduction:PTS:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 139 "DNA-directed RNA polymerase, beta subunit/140 kD subunit:DNA-directed RNA polymerase, beta' subunit/160 kD subunit:Ribosomal protein S13:Ribosomal protein S11:DNA-directed RNA polymerase, alpha subunit/40 kD subunit:Ribosomal protein L17:Translation initiation factor 1 (IF-1):Translation elongation factors (GTPases):Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:ABC-type metal ion transport system, ATPase component:4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase:ABC-type metal ion transport system, permease component:Uncharacterized conserved protein:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Ribosome:RNA polymerase:Function unknown:infA:L17:ispE:small_GTP:rpmJ_bact:purR_Bsub:rpoB:rpoA:rpoC_TIGR:bact_S13:bact_S11:Biosynthesis of cofactors, prosthetic groups, and carriers:Nucleotide Metabolism:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Transcription:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Regulatory functions:DNA interactions:Transcription:DNA-dependent RNA polymerase:Protein synthesis:Ribosomal proteins: synthesis and modification:Translation factors:Unknown function:General:Metabolism:Other:Information storage and processing:Metabolism:Poorly characterized" 140 "Methionine aminopeptidase:Ribosomal protein S8:Ribosomal protein S5:Ribosomal protein S13:Ribosomal protein S11:Ribosomal protein L24:Ribosomal protein S14:Ribosomal protein L15:Preprotein translocase subunit SecY:Ribosomal protein L18:Translation initiation factor 1 (IF-1):Adenylate kinase and related kinases:Ribosomal protein L30/L7E:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Purine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:Protein export:Bacterial secretion system:infA:L18_bact:met_pdase_I:3a0501s007:rpsE_bact:rpmJ_bact:rplO_bact:rplX_bact:rpmD_bact:adk:bact_S13:bact_S11:Intracellular trafficking, secretion, and vesicular transport:Protein and peptide secretion and trafficking:Nucleotide Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Protein synthesis:Ribosomal proteins: synthesis and modification:Translation factors:Protein fate:Metabolism:Protein modification and repair:Information storage and processing:Cellular processes and signaling:Metabolism" 141 "Energy production and conversion:1,4-alpha-glucan branching enzyme:Asparagine synthase (glutamine-hydrolyzing):ADP-glucose pyrophosphorylase:Serine/threonine protein kinase:Predicted Fe-S oxidoreductases:DNA-directed RNA polymerase specialized sigma subunit:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Transcriptional regulator:Lysine 2,3-aminomutase:Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit:Cytochrome c, mono- and diheme variants:Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit:Adenosine deaminase:Serine phosphatase RsbU, regulator of sigma subunit:Methylase involved in ubiquinone/menaquinone biosynthesis:Uncharacterized protein containing a von Willebrand factor type A (vWA) domain:Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase:H+/citrate symporter:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Oxidative phosphorylation:Alanine aspartate and glutamate metabolism:Lysine degradation:Cyanoamino acid metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Phosphotransferase system (PTS):RNA polymerase:General function prediction only:Signal transduction mechanisms:TIGR00238:citMHS:PTBA:branching_enzym:asn_synth_AEB:glgD:pcaJ_scoB_fam:pcaI_scoA_fam:spore_sigG:spore_II_E:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Transcription:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Biosynthesis and degradation of polysaccharides:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cellular processes:Sporulation and germination:Amino acid biosynthesis:Aspartate family:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 142 "Energy production and conversion:ATPase components of ABC transporters with duplicated ATPase domains:ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member:Na+/proline symporter:MoxR-like ATPases:Type II restriction enzyme, methylase subunits:HD superfamily phosphohydrolases:Chromosome segregation ATPases:ABC-type transport system involved in multi-copper enzyme maturation, permease component:Uncharacterized conserved protein:Na+/H+-dicarboxylate symporters:Thymidine kinase:Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain):Predicted membrane protein:Barstar, RNAse (barnase) inhibitor:Arabinose efflux permease:5-keto 4-deoxyuronate isomerase:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Pentose and glucuronate interconversions:Pyrimidine metabolism:Metabolic pathways:ABC transporters:Homologous recombination:General function prediction only:Function unknown:sss:recD_rel:SMC_prok_B:nudix_YtkD:Defense mechanisms:Information storage and processing:Enzymes of unknown specificity:Unknown function:Cations and iron carrying compounds:Transport and binding proteins:Chromosome-associated proteins:DNA replication, recombination, and repair:DNA metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Nucleotide Metabolism:Carbohydrate Metabolism" 143 "ABC-type sugar transport system, permease component:ABC-type sugar transport systems, permease components:Phosphotransferase system cellobiose-specific component IIB:Phosphotransferase system cellobiose-specific component IIA:Phosphotransferase system cellobiose-specific component IIC:Phosphomannose isomerase:ABC-type sugar transport system, periplasmic component:Beta-galactosidase:Transcriptional regulator/sugar kinase:Transcriptional regulators:AraC-type DNA-binding domain-containing proteins:Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase:Lysophospholipase L1 and related esterases:Beta-mannanase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Fructose and mannose metabolism:Galactose metabolism:Cyanoamino acid metabolism:Starch and sucrose metabolism:Other glycan degradation:Amino sugar and nucleotide sugar metabolism:Sphingolipid metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Phosphotransferase system (PTS):manA:cello_pts_IIC:Sugars:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Lipid Metabolism:Information storage and processing:Carbohydrate Metabolism:Metabolism:PTS:Signal transduction" 144 "Energy production and conversion:Uroporphyrinogen-III methylase:Sulfite reductase, beta subunit (hemoprotein):Seryl-tRNA synthetase:3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes:Pyridoxine biosynthesis enzyme:Phosphate/sulphate permeases:Predicted glutamine amidotransferase involved in pyridoxine biosynthesis:Sulfite reductase, alpha subunit (flavoprotein):ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Adenylylsulfate kinase and related kinases:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type polar amino acid transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Metal-dependent amidase/aminoacylase/carboxypeptidase:Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain):ATP sulfurylase (sulfate adenylyltransferase):Uncharacterized conserved protein:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Arginine and proline metabolism:Selenocompound metabolism:Vitamin B6 metabolism:Porphyrin and chlorophyll metabolism:Sulfur metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:Signal transduction mechanisms:sopT:TIGR00343:serS:cysH:apsK:cobA_cysG_Cterm:cysG_Nterm:HEQRo_perm_3TM:oligo_HPY:amidohydrolases:cysJ:CysI:PLP_synth_Pdx2:FMN_nitrolo:Global:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Central intermediary metabolism:Sulfur metabolism:Protein synthesis:tRNA aminoacylation:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Amino acids, peptides and amines:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Pyridoxine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism" 145 "Energy production and conversion:Fumarase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Geranylgeranyl pyrophosphate synthase:Cell division GTPase:Dienelactone hydrolase and related enzymes:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:Actin-like ATPase involved in cell division:UDP-glucose 4-epimerase:Uncharacterized protein conserved in bacteria:Transcriptional regulator:Uncharacterized conserved protein:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Uncharacterized protein conserved in bacteria:Uncharacterized conserved small protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Citrate cycle (TCA cycle):Galactose metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Amino sugar and nucleotide sugar metabolism:Carbon fixation pathways in prokaryotes:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:Signal transduction mechanisms:ftsZ:lytR_cpsA_psr:DegV:fumC_II:ilvE_II:ftsA:galE:spore_sigH:sigma70-ECF:YvyF:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:TCA cycle:Sugars:Regulatory functions:Other:Cellular processes:Cell division:Sporulation and germination:Unknown function:General:Amino acid biosynthesis:Pyruvate family:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 146 "Dethiobiotin synthetase:7-keto-8-aminopelargonate synthetase and related enzymes:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Thiamine monophosphate synthase:Thiamine biosynthesis protein ThiC:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:Biotin synthase and related enzymes:ABC-type cobalt transport system, permease component CbiQ and related transporters:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Signal transduction histidine kinase:Glycine/D-amino acid oxidases (deaminating):Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Putative transcription activator:ATPase components of various ABC-type transport systems, contain duplicated ATPase:Pimeloyl-CoA synthetase:Uncharacterized enzyme of thiazole biosynthesis:Sulfur transfer protein involved in thiamine biosynthesis:Predicted membrane protein:Predicted membrane protein:Predicted membrane protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Transcription:Inorganic ion transport and metabolism:Arginine and proline metabolism:Thiamine metabolism:Biotin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Sulfur relay system:General function prediction only:Function unknown:Signal transduction mechanisms:HMP-P_kinase:thiC:bioD:bioB:bioA:bioF:bioW:thiS:DapE-ArgE:thiamin_ThiO:Metabolism:Cellular processes and signaling:Information storage and processing:Thiamine:Biotin:Biosynthesis of cofactors, prosthetic groups, and carriers:Degradation of proteins, peptides, and glycopeptides:Protein fate:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Poorly characterized:Amino Acid Metabolism" 147 "Glycosidases:Predicted dehydrogenases and related proteins:Catalase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Uncharacterized conserved protein:Uncharacterized anaerobic dehydrogenase:Mn-containing catalase:ABC-type sugar transport system, auxiliary component:Carbohydrate transport and metabolism:Lipid transport and metabolism:Inorganic ion transport and metabolism:Tryptophan metabolism:Starch and sucrose metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Fdh-alpha:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Global:Metabolism:Metabolism:Metabolism" 148 "Energy production and conversion:Methyl-accepting chemotaxis protein:NAD-dependent aldehyde dehydrogenases:Flagellar hook-associated protein:Flagellar motor component:Uncharacterized flagellar protein FlaG:Flagellin and related hook-associated proteins:Flagellar capping protein:Flagellar motor protein:Flagellin-specific chaperone FliS:Negative regulator of flagellin synthesis (anti-sigma28 factor):Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Fatty acid metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Propanoate metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Flagellar assembly:Signal transduction mechanisms:fliS:flgK_ends:flagell_flgL:FlgM_jcvi:Intracellular trafficking, secretion, and vesicular transport:Global:Carbohydrate Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Metabolism:Metabolism:Cellular processes:Chemotaxis and motility:Information storage and processing:Cellular processes and signaling:Metabolism" 149 "Energy production and conversion:Predicted sugar kinase:Malic enzyme:Short-chain dehydrogenases of various substrate specificities:Lactoylglutathione lyase and related lyases:Protein-tyrosine-phosphatase:Exoribonuclease R:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Transcription-repair coupling factor (superfamily II helicase):Uncharacterized conserved protein:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Esterase/lipase:Regulators of stationary/sporulation gene expression:Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog):Uncharacterized protein containing double-stranded beta helix domain:Galactose-1-phosphate uridyltransferase:L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily:Predicted Zn-dependent protease:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Galactose metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:RNA degradation:Nucleotide excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:yjeF_cterm:3_prime_RNase:ant_ant_sig:mfd:2A0118:galT_2:lp_hng_hel_AbrB:menC_lowGC/arch:Metabolism:Poorly characterized:Protein interactions:DNA interactions:Regulatory functions:Sugars:Energy metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Replication and Repair:Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:DNA metabolism:Carbohydrate Metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Information storage and processing:Cellular processes and signaling" 150 "Cysteine synthase:Co-chaperonin GroES (HSP10):Chaperonin GroEL (HSP60 family):IMP dehydrogenase/GMP reductase:Transcriptional regulator:Cystathionine beta-lyases/cystathionine gamma-synthases:Signal transduction histidine kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Non-ribosomal peptide synthetase modules and related proteins:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type multidrug transport system, ATPase component:Molybdopterin converting factor, small subunit:Uncharacterized conserved protein:Methylase involved in ubiquinone/menaquinone biosynthesis:Beta-lactamase class A:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Predicted membrane protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Pentose and glucuronate interconversions:Purine metabolism:Cysteine and methionine metabolism:Penicillin and cephalosporin biosynthesis:Selenocompound metabolism:Nitrogen metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:RNA degradation:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:NaPi_cotrn_rel:cysKM:IMP_dehydrog:moaD:AA-adenyl-dom:kduD:GroEL:TIGR03943:Defense mechanisms:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein fate:Protein folding and stabilization:Transport and binding proteins:Cations and iron carrying compounds:Amino acid biosynthesis:Serine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 151 "Energy production and conversion:Cysteine synthase:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:Predicted choline kinase involved in LPS biosynthesis:Superfamily II DNA helicase:ABC-type Fe3+-siderophore transport system, permease component:Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:Ferredoxin:DNA-directed RNA polymerase specialized sigma subunit:Predicted metal-dependent membrane protease:Cold shock proteins:Choline-glycine betaine transporter:Transcriptional regulator:DNA polymerase III, delta subunit:Micrococcal nuclease (thermonuclease) homologs:1,4-dihydroxy-2-naphthoate octaprenyltransferase:Predicted transcriptional regulators:Transcriptional regulators:Predicted acyltransferase:Putative NADPH-quinone reductase (modulator of drug activity B):Predicted membrane protein:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Terpenoid backbone biosynthesis:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:RNA degradation:RNA polymerase:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:ispG_gcpE:recQ_fam:menA:bcct:holA:cysKM:spore_sigI:Menaquinone and ubiquinone:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Serine family:Amino acid biosynthesis:Sporulation and germination:Cellular processes:Other:Transport and binding proteins:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Replication and Repair:Folding Sorting and Degradation:Transcription:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing" 152 "Energy production and conversion:Sugar kinases, ribokinase family:Transcriptional regulator:Predicted sugar phosphatases of the HAD superfamily:2-keto-3-deoxy-6-phosphogluconate aldolase:Ribulose kinase:ABC-type sugar transport systems, permease components:Transcriptional regulator:Beta-galactosidase:Glucuronate isomerase:L-arabinose isomerase:Maltose-binding periplasmic proteins/domains:Na+/melibiose symporter and related transporters:Arabinose efflux permease:H+/citrate symporter:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase regulating citrate/malate metabolism:Alpha-L-arabinofuranosidase:ABC-type maltose transport systems, permease component:Arabinogalactan endo-1,4-beta-galactosidase:Response regulator of citrate/malate metabolism:Carbohydrate transport and metabolism:Transcription:Pentose phosphate pathway:Pentose and glucuronate interconversions:Galactose metabolism:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Glyoxylate and dicarboxylate metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Bacterial chemotaxis:Function unknown:Signal transduction mechanisms:citMHS:gph:kdgT:eda:L-ribulokinase:HAD-SF-IIA:Cellular processes and signaling:Information storage and processing:Enzymes of unknown specificity:Unknown function:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Sugars:Entner-Doudoroff:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Membrane Transport:Environmental Information Processing:Amino Acid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism" 153 "Uncharacterized protein containing LysM domain:Mu-like prophage tail protein gpP:General function prediction only:Function unknown:holin_SPP1:phage_XkdX:Poorly characterized:Prophage functions:Mobile and extrachromosomal element functions" 154 "Energy production and conversion:Ribosomal protein L33:ATPase components of ABC transporters with duplicated ATPase domains:Superfamily II DNA and RNA helicases:Uncharacterized membrane-associated protein:Small-conductance mechanosensitive channel:Na+-dependent transporters of the SNF family:Cation/multidrug efflux pump:D-alanine-D-alanine ligase and related ATP-grasp enzymes:Uncharacterized conserved protein:Na+/H+-dicarboxylate symporters:Transcriptional regulator:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:Uncharacterized Fe-S protein:Transcriptional regulators:Predicted HD-superfamily hydrolase:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:D-Alanine metabolism:Peptidoglycan biosynthesis:Metabolic pathways:Ribosome:General function prediction only:Function unknown:TIGR00276:rpmG_bact:D_ala_D_alaTIGR:Defense mechanisms:Poorly characterized:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Translation:Global:Metabolism:Energy metabolism:Electron transport:Protein synthesis:Ribosomal proteins: synthesis and modification:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 155 "Energy production and conversion:Arginyl-tRNA synthetase:Aspartate-semialdehyde dehydrogenase:FAD/FMN-containing dehydrogenases:Preprotein translocase subunit SecD:Aspartate/tyrosine/aromatic aminotransferase:Pseudouridylate synthases, 23S RNA-specific:ABC-type antimicrobial peptide transport system, permease component:Predicted hydrolase of the metallo-beta-lactamase superfamily:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Signal peptidase I:RNase PH:Membrane-fusion protein:ABC-type antimicrobial peptide transport system, ATPase component:Threonine dehydratase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted transcriptional regulators:Transcriptional regulators:Uncharacterized bacitracin resistance protein:Uncharacterized protein involved in cation transport:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Peptidoglycan biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:RNA degradation:Protein export:Bacterial secretion system:General function prediction only:Function unknown:rluA_subfam:argS:MG423:undec_PP_bacA:DegV:2A0604s01:asd_B:ccpA:RNasePH:THD1:sigpep_I_bact:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Biosynthesis and degradation of murein sacculus and peptidoglycan:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Regulatory functions:DNA interactions:Transcription:RNA processing:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Hypothetical proteins:Conserved:Unknown function:General:Amino acid biosynthesis:Aspartate family:Pyruvate family:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 156 "Energy production and conversion:Cation transport ATPase:NAD-dependent aldehyde dehydrogenases:Gamma-aminobutyrate permease and related permeases:ABC-type sugar transport systems, permease components:Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit:Maltose-binding periplasmic proteins/domains:H+/gluconate symporter and related permeases:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase regulating citrate/malate metabolism:Uncharacterized conserved protein:Uncharacterized conserved protein:ABC-type maltose transport systems, permease component:Arabinogalactan endo-1,4-beta-galactosidase:Uncharacterized membrane protein:Response regulator of citrate/malate metabolism:Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain:Spore germination protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Fatty acid metabolism:Synthesis and degradation of ketone bodies:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Propanoate metabolism:Butanoate metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:ATPase-IIA1_Ca:pcaI_scoA_fam:RhaD_aldol-ADH:Metabolism:Global:Cell Motility:Cellular Processes:Metabolism:Signal Transduction:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Cations and iron carrying compounds:Transport and binding proteins" 157 "3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase:Ribonuclease HI:Predicted Na+-dependent transporter:Predicted SAM-dependent methyltransferases:Monoamine oxidase:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Transcriptional regulators:Acetyltransferases, including N-acetylases of ribosomal proteins:Predicted transcriptional regulators:Uncharacterized conserved protein:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Adenosine deaminase:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:AraC-type DNA-binding domain-containing proteins:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase:Transcriptional regulator, effector-binding domain/component:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Two-component system:DNA replication:Base excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00697:DegV:bass:Bac_small_yrzI:Information storage and processing:General:Unknown function:Conserved:Hypothetical proteins:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Signal Transduction:Environmental Information Processing:Genetic Information Processing:Replication and Repair:Poorly characterized:Metabolism:Cellular processes and signaling" 158 "Alanyl-tRNA synthetase:Gamma-glutamyl phosphate reductase:Phenylalanyl-tRNA synthetase alpha subunit:Isoleucyl-tRNA synthetase:Phenylalanyl-tRNA synthetase beta subunit:Histidyl-tRNA synthetase:Tryptophanyl-tRNA synthetase:Glutamate 5-kinase:Leucyl-tRNA synthetase:Superfamily II DNA and RNA helicases:Lysophospholipase L1 and related esterases:Rhs family protein:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Tryptophan metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:trpS:alaS:ileS:leuS_bact:proA:hisS:pheS:pheT_bact:proB:YD_repeat_2x:Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Global:Metabolism:Protein synthesis:tRNA aminoacylation:Amino acid biosynthesis:Glutamate family:Information storage and processing:Cellular processes and signaling:Metabolism" 159 "Signal peptidase I:Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain:Hemolysins and related proteins containing CBS domains:Cold shock proteins:Transcriptional regulator:DNA polymerase III, delta subunit:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Acetyltransferases, including N-acetylases of ribosomal proteins:Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein:Cytochrome P450:Na+/melibiose symporter and related transporters:Lysophospholipase L1 and related esterases:Cyanate permease:Uncharacterized conserved protein:Pectate lyase:Predicted permease, DMT superfamily:Predicted transmembrane transcriptional regulator (anti-sigma factor):Uncharacterized conserved protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:RNA polymerase:DNA replication:Protein export:Mismatch repair:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:lytR_cpsA_psr:CynX:holA:sigpep_I_bact:sigma70-ECF:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Nucleotide Metabolism:Genetic Information Processing:Transcription:Folding Sorting and Degradation:Replication and Repair:Global:Metabolism:Regulatory functions:Other:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 160 "Energy production and conversion:Glutamyl- and glutaminyl-tRNA synthetases:Formamidopyrimidine-DNA glycosylase:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Recombinational DNA repair protein (RecF pathway):Uncharacterized conserved protein:ATP-dependent Zn proteases:NTP pyrophosphohydrolases including oxidative damage repair enzymes:DNA polymerase III, alpha subunit:Ribose 5-phosphate isomerase RpiB:DNA polymerase I - 3'-5' exonuclease and polymerase domains:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Uncharacterized protein conserved in bacteria:Uncharacterized protein required for formate dehydrogenase activity:Predicted P-loop-containing kinase:Phosphotransferase system, HPr-related proteins:Arylamine N-acetyltransferase:Anti-sigma regulatory factor (Ser/Thr protein kinase):Serine phosphatase RsbU, regulator of sigma subunit:Molybdenum cofactor biosynthesis enzyme:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Purine metabolism:Caffeine metabolism:Pyrimidine metabolism:Vitamin B6 metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:Homologous recombination:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:HMP-P_kinase:fdhD_narQ:gltX_bact:fpg:pola:polc:recR:MG103:rpiB_lacA_lacB:PTS_HPr_family:FtsH_fam:TIGR01440:CofD_related:moaA:Metabolism:Global:Metabolism:Replication and Repair:Folding Sorting and Degradation:Translation:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:DNA replication, recombination, and repair:Carbohydrate Metabolism:Protein synthesis:tRNA aminoacylation:Protein fate:Degradation of proteins, peptides, and glycopeptides:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Thiamine:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:DNA metabolism:Electron transport:Energy metabolism" 161 "Energy production and conversion:FAD/FMN-containing dehydrogenases:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Protein-tyrosine-phosphatase:FOG: CBS domain:Predicted transcriptional regulators:Aldo/keto reductases, related to diketogulonate reductase:Nitroreductase:Predicted transcriptional regulators:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1:Co/Zn/Cd efflux system component:Predicted membrane protein:Predicted transcriptional regulators:Transcriptional regulators:Predicted flavoprotein involved in K+ transport:Cation transport ATPase:Putative NADPH-quinone reductase (modulator of drug activity B):Arabinose efflux permease:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:General function prediction only:Function unknown:Signal transduction mechanisms:CDF:ATPase_P-type:yecD_yerC:arsC_pI258_fam:TIGR03833:General:Unknown function:Conserved:Hypothetical proteins:Detoxification:Cellular processes:Cations and iron carrying compounds:Transport and binding proteins:Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing" 162 "Predicted Fe-S oxidoreductases:ABC-type antimicrobial peptide transport system, permease component:Periplasmic serine proteases (ClpP class):Membrane-fusion protein:Membrane-bound serine protease (ClpP class):Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold:ABC-type multidrug transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:Beta-propeller domains of methanol dehydrogenase type:Predicted membrane protein/domain:Phage shock protein A (IM30), suppresses sigma54-dependent transcription:Uncharacterized conserved protein:Predicted membrane protein:Putative virion core protein (lumpy skin disease virus):Uncharacterized protein conserved in bacteria:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycerolipid metabolism:Metabolic pathways:ABC transporters:General function prediction only:Function unknown:Signal transduction mechanisms:SppA_dom:RND_mfp:spore_yqfC:toxin_SdpC:export_SdpB:export_SdpA:rSAM_yydG:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Cellular processes and signaling:Lipid Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Regulatory functions:Protein interactions:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Unknown substrate:Cellular processes:Sporulation and germination:Information storage and processing:Metabolism:Poorly characterized" 163 "Lactoylglutathione lyase and related lyases:Putative GTPases (G3E family):Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Cytochrome P450:Amino acid transport and metabolism:Bisphenol degradation:Polycyclic aromatic hydrocarbon degradation:Aminobenzoate degradation:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:spore_YlmC_YmxH:Cellular processes:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Global:Metabolism:Metabolism:Sporulation and germination:Metabolism:Poorly characterized" 164 "Thymidine phosphorylase:Diaminopimelate epimerase:NTP pyrophosphohydrolases including oxidative damage repair enzymes:Na+-driven multidrug efflux pump:2-methylthioadenine synthetase:Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB):ABC-type multidrug transport system, ATPase component:Acyl carrier protein phosphodiesterase:RecG-like helicase:Phosphotransferase system, fructose-specific IIC component:Transcriptional regulators of sugar metabolism:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Transcriptional regulators:L-serine deaminase:Periplasmic molybdate-binding protein/domain:Nucleoside permease:AraC-type DNA-binding domain-containing proteins:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Phosphotransferase system (PTS):RNA polymerase:Homologous recombination:General function prediction only:Function unknown:TIGR00089:recG:DapF:sda_alpha:sda_beta:matE:nupC:FRU:excise:Y_phosphoryl:sigma70-ECF:1-PFK:Defense mechanisms:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Transcription:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Purines, pyrimidines, nucleosides, and nucleotides:Other:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Nucleosides, purines and pyrimidines:Other:Unknown function:General:Amino acid biosynthesis:Aspartate family:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 165 "Signal peptidase I:Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Alkaline phosphatase:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Synthesis and degradation of ketone bodies:Aminobenzoate degradation:Butanoate metabolism:Folate biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Protein export:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:PHB_DH:sigpep_I_bact:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Metabolism:Poorly characterized:Folding Sorting and Degradation:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Lipid Metabolism:Signal Transduction:Carbohydrate Metabolism:Global:Metabolism:Environmental Information Processing:Metabolism:Protein fate:Protein and peptide secretion and trafficking" 166 "Uncharacterized conserved protein:GTPases - translation elongation factors:Shikimate 5-dehydrogenase:Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis:ATP-dependent Zn proteases:Parvulin-like peptidyl-prolyl isomerase:Membrane-bound serine protease (ClpP class):Nicotinic acid mononucleotide adenylyltransferase:ABC-type multidrug transport system, ATPase component:Disulfide bond chaperones of the HSP33 family:Transcriptional regulator:Uncharacterized conserved protein:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Predicted membrane protein:Putative stress-responsive transcriptional regulator:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized protein involved in tellurite resistance:Uncharacterized protein conserved in bacteria:Predicted ABC-type exoprotein transport system, permease component:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted transmembrane transcriptional regulator (anti-sigma factor):Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Nicotinate and nicotinamide metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:RNA polymerase:Function unknown:Signal transduction mechanisms:TIGR00006:TIGR00106:cyt_tran_rel:small_GTP:TIGR00242:lytR_cpsA_psr:aroE:sigma70-ECF:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Metabolism of Cofactors and Vitamins:Poorly characterized:Amino Acid Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope:Aromatic amino acid family:Metabolism:Amino acid biosynthesis:General:Unknown function:Other:Regulatory functions:Metabolism:Global:Transcription:Genetic Information Processing" 167 "Transcriptional regulator:ABC-type metal ion transport system, periplasmic component/surface antigen:Transcriptional regulators:Multiple antibiotic transporter:FOG: EAL domain:Uncharacterized protein conserved in bacteria:Pleiotropic transcriptional repressor:Uncharacterized conserved protein:Transcription:Inorganic ion transport and metabolism:ABC transporters:Function unknown:Signal transduction mechanisms:TIGR00427:codY_Gpos:Intracellular trafficking, secretion, and vesicular transport:DNA interactions:Regulatory functions:Information storage and processing:Membrane Transport:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:General:Unknown function" 168 "Energy production and conversion:3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase:Deoxyribose-phosphate aldolase:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Isocitrate/isopropylmalate dehydrogenase:Sugar kinases, ribokinase family:Transcriptional regulator:2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:2-keto-3-deoxy-6-phosphogluconate aldolase:NAD-dependent aldehyde dehydrogenases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Phosphotransferase system, fructose-specific IIC component:Na+/H+-dicarboxylate symporters:Transcriptional regulators:Predicted membrane protein:Sugar phosphate permease:H+/gluconate symporter and related permeases:H+/citrate symporter:Beta-xylosidase:5-keto 4-deoxyuronate isomerase:L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose and glucuronate interconversions:Fructose and mannose metabolism:Ascorbate and aldarate metabolism:Fatty acid metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Phosphotransferase system (PTS):Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:deoC:citMHS:gntP:kdgT:FRU:eda:kduD:TTC:glucar-dehydr:KdgD:WXG100_ESAT6:Cellular processes and signaling:Carbohydrate Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Energy metabolism:Entner-Doudoroff:Biosynthesis and degradation of polysaccharides:Other:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Signal transduction:PTS:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 169 "Energy production and conversion:Malate/lactate dehydrogenases:Succinyl-CoA synthetase, beta subunit:Succinyl-CoA synthetase, alpha subunit:NAD synthase:Fe-S oxidoreductase:Malic enzyme:Glutamate dehydrogenase/leucine dehydrogenase:Citrate synthase:Glycine cleavage system T protein (aminomethyltransferase):Zn-dependent hydrolases, including glyoxylases:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:Isocitrate dehydrogenases:2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes:Cell wall-associated hydrolases (invasion-associated proteins):Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain:Lactate dehydrogenase and related dehydrogenases:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:ATPases involved in chromosome partitioning:Predicted transcriptional regulators:2'-5' RNA ligase:DNA segregation ATPase FtsK/SpoIIIE and related proteins:Succinate dehydrogenase/fumarate reductase, cytochrome b subunit:Uncharacterized conserved protein:Uncharacterized anaerobic dehydrogenase:Ornithine/acetylornithine aminotransferase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Citrate cycle (TCA cycle):Pentose phosphate pathway:Oxidative phosphorylation:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Lysine degradation:Arginine and proline metabolism:Tryptophan metabolism:Glutathione metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:One carbon pool by folate:Methane metabolism:Carbon fixation pathways in prokaryotes:Nicotinate and nicotinamide metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:parB_part:prok_nadp_idh:2oxo_dh_E1:gcvT:nadE:sucCoAbeta:sucCoAalpha:sucB:Fdh-alpha:MalateDH_bact:cit_synth_II:sdhA_Bsu:Orn_aminotrans:sdhC_b558_fam:2_5_ligase:Metabolism:Cellular processes and signaling:Information storage and processing:Pyridine nucleotides:Biosynthesis of cofactors, prosthetic groups, and carriers:RNA processing:Transcription:TCA cycle:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism" 170 "Shikimate 5-dehydrogenase:Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels:Na+-driven multidrug efflux pump:UDP-N-acetylglucosamine enolpyruvyl transferase:Cell division protein FtsI/penicillin-binding protein 2:UDP-N-acetylmuramyl pentapeptide synthase:Diacylglycerol kinase:Nicotinic acid mononucleotide adenylyltransferase:Hemolysins and related proteins containing CBS domains:Transcriptional regulator:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:Predicted membrane-associated HD superfamily hydrolase:Uncharacterized protein conserved in bacteria:Cell division septal protein:Uncharacterized proteins, homologs of microcin C7 resistance protein MccF:Ketopantoate reductase:Arginine/lysine/ornithine decarboxylases:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Predicted transcriptional regulator:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Pleiotropic transcriptional repressor:Protein required for the initiation of cell division:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Lysine biosynthesis:Arginine and proline metabolism:Histidine metabolism:Tyrosine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Selenocompound metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:Polycyclic aromatic hydrocarbon degradation:Nicotinate and nicotinamide metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:cyt_tran_rel:HDIG:lytR_cpsA_psr:rumA:aroE:apbA_panE:matE:murA:murF:ftsL_broad:codY_Gpos:Defense mechanisms:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Signal Transduction:Global:Metabolism:Regulatory functions:Other:DNA interactions:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Other:Cellular processes:Cell division:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 171 "Na+-driven multidrug efflux pump:Adenylate kinase and related kinases:Signal transduction histidine kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Predicted thioesterase:Sortase and related acyltransferases:DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog:Acetyltransferases, including N-acetylases of ribosomal proteins:Uncharacterized conserved protein:Transcriptional regulators:AraC-type DNA-binding domain-containing proteins:Uncharacterized protein conserved in bacteria:Beta-lactamase class D:Ketosteroid isomerase homolog:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Penicillin and cephalosporin biosynthesis:Biosynthesis of secondary metabolites:Two-component system:RNA polymerase:General function prediction only:Function unknown:Signal transduction mechanisms:matE:rpoN_sigma:Defense mechanisms:Environmental Information Processing:Transcription:Genetic Information Processing:Other:Biosynthesis of Other Secondary Metabolites:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Transport and binding proteins:Transcription factors:Transcription:Metabolism:Global:Signal Transduction" 172 "Energy production and conversion:F0F1-type ATP synthase, beta subunit:F0F1-type ATP synthase, alpha subunit:F0F1-type ATP synthase, gamma subunit:F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit):F0F1-type ATP synthase, subunit a:F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein):Predicted hydrolase (HAD superfamily):Non-ribosomal peptide synthetase modules and related proteins:Predicted membrane protein involved in D-alanine export:Putative regulator of cell autolysis:Response regulator of the LytR/AlgR family:Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein):Predicted membrane protein:Transcription:Cell wall/membrane/envelope biogenesis:Oxidative phosphorylation:D-Alanine metabolism:Metabolic pathways:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:atpA:atpD:ATP_synt_6_or_A:ATP_synt_delta:ATPsyn_F1gamma:ATP_synt_epsi:ATP_synt_c:HAD-SF-IA-v3:dltC:AA-adenyl-dom:int_mem_ywzB:LTA_dltB:LTA_DltD:Poorly characterized:Energy Metabolism:Metabolism of Other Amino Acids:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Unknown function:Enzymes of unknown specificity:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 173 "4-aminobutyrate aminotransferase and related aminotransferases:Uncharacterized conserved protein:Glutamyl-tRNA reductase:ATPase involved in DNA replication:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:ATPases involved in chromosome partitioning:Predicted transcriptional regulators:Phosphate starvation-inducible protein PhoH, predicted ATPase:Uncharacterized protein conserved in bacteria:Ketopantoate reductase:Uncharacterized protein with SCP/PR1 domains:Signal transduction histidine kinase, nitrogen specific:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine degradation:beta-Alanine metabolism:Propanoate metabolism:Butanoate metabolism:Pantothenate and CoA biosynthesis:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:DNA replication:Mismatch repair:Homologous recombination:Function unknown:Signal transduction mechanisms:TIGR00093:parB_part:sensory_box:holB:GABAtrnsam:apbA_panE:TIGR01033:hemA:spore_YkwD:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:DNA replication, recombination, and repair:DNA metabolism:Small molecule interactions:DNA interactions:Regulatory functions:Other:Central intermediary metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Protein synthesis:Carbohydrate Metabolism:tRNA and rRNA base modification" 174 "Energy production and conversion:Fe-S oxidoreductase:FAD/FMN-containing dehydrogenases:Predicted permease:5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases:Periplasmic protease:Flavodoxin reductases (ferredoxin-NADPH reductases) family 1:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Uncharacterized protein conserved in bacteria:Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family:Membrane transporters of cations and cationic drugs:Uncharacterized protein conserved in bacteria:Spore coat protein:Nucleotide transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Glyoxylate and dicarboxylate metabolism:Metabolic pathways:Microbial metabolism in diverse environments:RNA polymerase:General function prediction only:Function unknown:prc:glcD:yecD_yerC:sigma70-ECF:Information storage and processing:Carbohydrate Metabolism:Nucleotide Metabolism:Genetic Information Processing:Transcription:Global:Metabolism:Energy metabolism:Other:Protein fate:Protein modification and repair:Unknown function:General:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 175 "Energy production and conversion:Lactoylglutathione lyase and related lyases:Sulfite reductase, alpha subunit (flavoprotein):Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Predicted membrane protein:ABC-type Na+ efflux pump, permease component:Transcriptional regulators:Sugar phosphate permease:Predicted membrane protein:Predicted drug exporters of the RND superfamily:Arabinose efflux permease:L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Fatty acid metabolism:Tryptophan metabolism:Aminobenzoate degradation:Microbial metabolism in diverse environments:ABC transporters:Two-component system:General function prediction only:Function unknown:2A0114:metmalonyl_epim:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Amino Acid Metabolism:Lipid Metabolism" 176 "Glutamate synthase domain 2:Pseudouridylate synthase:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:Uridine kinase:ABC-type cobalt transport system, permease component CbiQ and related transporters:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:ABC-type cobalt transport system, ATPase component:ABC-type multidrug transport system, ATPase component:Transcriptional regulator:Uncharacterized proteins, homologs of lactam utilization protein B:Mn2+ and Fe2+ transporters of the NRAMP family:Allophanate hydrolase subunit 2:Allophanate hydrolase subunit 1:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Peptidoglycan biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:hisT_truA:udk:TIGR00370:urea_amlyse_rel:murG:GOGAT_sm_gam:Defense mechanisms:General:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:Protein synthesis:tRNA and rRNA base modification:Hypothetical proteins:Conserved:Unknown function:Metabolism:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 177 "Thioredoxin reductase:Mg2+ and Co2+ transporters:Protease subunit of ATP-dependent Clp proteases:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:Uncharacterized conserved protein:Purine-cytosine permease and related proteins:Predicted transcriptional regulator:O-Methyltransferase involved in polyketide biosynthesis:ABC-type molybdate transport system, permease component:Nucleotide transport and metabolism:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:mthyl_TIGR00027:corA:rrf2_super:modB_ABC:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Nucleotide Metabolism:Environmental Information Processing:Membrane Transport:Transport and binding proteins:Anions:Cations and iron carrying compounds:Unknown function:Enzymes of unknown specificity:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 178 "Energy production and conversion:Lactoylglutathione lyase and related lyases:ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components:Nitroreductase:Membrane protein TerC, possibly involved in tellurium resistance:Flavodoxin reductases (ferredoxin-NADPH reductases) family 1:Cytochrome bd-type quinol oxidase, subunit 1:Uncharacterized protein conserved in bacteria:Subtilisin-like serine proteases:Predicted membrane protein:L-lactate permease:Transcriptional regulators:Predicted membrane protein:Predicted drug exporters of the RND superfamily:DNA alkylation repair enzyme:Amino acid transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Metabolic pathways:ABC transporters:General function prediction only:Function unknown:lctP:SsuA_fam:xxxLxxG_by_4:R_switched_YkoY:Other:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Metabolism:Global:Membrane Transport:Environmental Information Processing:Poorly characterized:Energy Metabolism:Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing" 179 "Energy production and conversion:Anaerobic dehydrogenases, typically selenocysteine-containing:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Predicted naringenin-chalcone synthase:Pectate lyase:Carbohydrate transport and metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:spore_BofA:Global:Metabolism:Poorly characterized:Cellular processes:Metabolism:Sporulation and germination" 180 "Energy production and conversion:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:ABC-type antimicrobial peptide transport system, permease component:Permeases of the drug/metabolite transporter (DMT) superfamily:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:ADP-ribose pyrophosphatase:Threonine dehydrogenase and related Zn-dependent dehydrogenases:ABC-type multidrug transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:ABC-type Na+ efflux pump, permease component:Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit:Uncharacterized membrane protein, possible Na+ channel or pump:Glucuronate isomerase:Na+/melibiose symporter and related transporters:Altronate dehydratase:Arabinose efflux permease:Uncharacterized conserved protein:Predicted glycosyl hydrolase:Predicted integral membrane protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Fructose and mannose metabolism:Ascorbate and aldarate metabolism:Synthesis and degradation of ketone bodies:Valine leucine and isoleucine degradation:Butanoate metabolism:Metabolic pathways:ABC transporters:General function prediction only:Function unknown:gph:2A0309:tiny_TM_bacill:intg_mem_TP0381:pcaI_scoA_fam:spore_ger_x_C:galactar-dH20:Defense mechanisms:Cellular processes and signaling:Carbohydrate Metabolism:Lipid Metabolism:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transport and binding proteins:Amino acids, peptides and amines:Carbohydrates, organic alcohols, and acids:Cellular processes:Sporulation and germination:Hypothetical proteins:Conserved:Metabolism:Metabolism:Poorly characterized" 181 "Nucleotidyltransferase/DNA polymerase involved in DNA repair:Replication, recombination and repair:Information storage and processing" 182 "Energy production and conversion:Fructose/tagatose bisphosphate aldolase:Sugar kinases, ribokinase family:Predicted dehydrogenases and related proteins:NAD-dependent aldehyde dehydrogenases:Sugar phosphate isomerases/epimerases:Sugar phosphate permease:Uncharacterized enzyme involved in inositol metabolism:Acetolactate synthase:Predicted integral membrane protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Valine leucine and isoleucine degradation:Streptomycin biosynthesis:Inositol phosphate metabolism:Propanoate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Function unknown:cbbA:MMSDH:Glycolysis/gluconeogenesis:Carbohydrate Metabolism:Amino Acid Metabolism:Biosynthesis of Other Secondary Metabolites:Global:Metabolism:Energy metabolism:Amino acids and amines:Metabolism:Metabolism:Poorly characterized" 183 "Galactokinase:Predicted amidohydrolase:Membrane carboxypeptidase (penicillin-binding protein):Sporulation control protein:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Galactose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:General function prediction only:gal_kin:PBP_1a_fam:Cell envelope:Carbohydrate Metabolism:Global:Metabolism:Energy metabolism:Sugars:Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cellular processes and signaling:Metabolism:Poorly characterized" 184 "DNA-directed RNA polymerase specialized sigma subunit:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Anti-sigma regulatory factor (Ser/Thr protein kinase):Transcription:RNA polymerase:Signal transduction mechanisms:ant_ant_sig:spIIAB:spore_sigmaE:spore_II_GA:spore_sigF:Protein interactions:Transcription:Regulatory functions:Genetic Information Processing:Cellular processes:Sporulation and germination:Information storage and processing:Cellular processes and signaling" 185 "Uroporphyrinogen-III methylase:3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes:Phosphate/sulphate permeases:Adenylylsulfate kinase and related kinases:Flagellar biosynthesis/type III secretory pathway ATPase:Flagellar basal body-associated protein:Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain):Flagellar hook capping protein:Flagellar motor switch protein:ATP sulfurylase (sulfate adenylyltransferase):Uncharacterized conserved protein:Flagellar biosynthesis chaperone:Flagellar hook-length control protein:Uncharacterized conserved protein:Predicted nucleotidyltransferase:Flagellar basal body rod protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Selenocompound metabolism:Porphyrin and chlorophyll metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:sopT:cysH:apsK:fliI_yscN:fliM_switch:cobA_cysG_Cterm:cysG_Nterm:flagell_FliJ:fliN:flgF:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Energy Metabolism:Nucleotide Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Sulfur metabolism:Energy metabolism:ATP-proton motive force interconversion:Cellular processes:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cellular processes and signaling:Metabolism:Metabolism" 186 "7-keto-8-aminopelargonate synthetase and related enzymes:Sugar kinases, ribokinase family:Threonine dehydrogenase and related Zn-dependent dehydrogenases:ABC-type sugar transport system, ATPase component:Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components:Phosphotransferase system cellobiose-specific component IIB:Phosphotransferase system cellobiose-specific component IIA:Phosphotransferase system cellobiose-specific component IIC:Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases:Transcriptional regulators:ABC-type ribose transport system, auxiliary component:ABC-type sugar transport system, periplasmic component:Carbon starvation protein, predicted membrane protein:ABC-type sugar transport systems, ATPase components:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Glycine serine and threonine metabolism:ABC transporters:Bacterial chemotaxis:Phosphotransferase system (PTS):General function prediction only:Signal transduction mechanisms:cello_pts_IIC:tdh:EIIA-LAC:pts-lac:bioF:D_ribokin_bact:Signal transduction:Carbohydrate Metabolism:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Energy metabolism:Amino acids and amines:Sugars:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Metabolism:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 187 "Energy production and conversion:Xanthosine triphosphate pyrophosphatase:5-enolpyruvylshikimate-3-phosphate synthase:Ribonuclease HII:Prephenate dehydrogenase:Glycosyltransferase:Molybdopterin biosynthesis enzymes:Pseudouridylate synthases, 23S RNA-specific:Predicted phosphoesterase:RNase PH:Uncharacterized membrane protein (homolog of Drosophila rhomboid):Bacterial cell division membrane protein:NADH dehydrogenase, FAD-containing subunit:L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases:Uroporphyrinogen-III synthase:Uncharacterized proteins, LmbE homologs:Uncharacterized protein conserved in bacteria:Capsular polysaccharide biosynthesis protein:Uncharacterized integral membrane protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Oxidative phosphorylation:Purine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:General function prediction only:Function unknown:rluA_subfam:yfcE:TIGR00042:molyb_syn:aroA:RNasePH:IPP_isom_2:thiol_BshA:thiol_BshB1:Poorly characterized:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Replication and Repair:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:RNA processing:Protein synthesis:tRNA and rRNA base modification:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Glutathione and analogs:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 188 "Energy production and conversion:Glutamate-1-semialdehyde aminotransferase:Delta-aminolevulinic acid dehydratase:Porphobilinogen deaminase:Dephospho-CoA kinase:Formamidopyrimidine-DNA glycosylase:Protoheme ferro-lyase (ferrochelatase):Malic enzyme:Recombinational DNA repair protein (RecF pathway):Ribosomal protein L9:Uncharacterized conserved protein:Uroporphyrinogen-III decarboxylase:NTP pyrophosphohydrolases including oxidative damage repair enzymes:Uncharacterized protein conserved in bacteria:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:DNA polymerase I - 3'-5' exonuclease and polymerase domains:ABC-type transport system involved in cytochrome c biogenesis, permease component:Cell division protein FtsI/penicillin-binding protein 2:Protoporphyrinogen oxidase:Uncharacterized protein conserved in bacteria:Uroporphyrinogen-III synthase:Predicted P-loop-containing kinase:Phosphotransferase system, HPr-related proteins:Predicted membrane protein:Arylamine N-acetyltransferase:Signal transduction histidine kinase regulating citrate/malate metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Caffeine metabolism:Pyrimidine metabolism:Pyruvate metabolism:Pantothenate and CoA biosynthesis:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Ribosome:DNA replication:Base excision repair:Nucleotide excision repair:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:DNA_YbaB_EbfC:hemH:TIGR00152:L9:hemC:proto_IX_ox:fpg:pola:recR:MG103:hemL:PTS_HPr_family:hemE:CofD_related:spore_YtaF:PTS:Signal transduction:Pantothenate and coenzyme A:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Unknown function:Conserved:Hypothetical proteins:Sporulation and germination:Cellular processes:Ribosomal proteins: synthesis and modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Replication and Repair:Translation:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing" 189 "Energy production and conversion:Polyprenyltransferase (cytochrome oxidase assembly factor):Protoheme ferro-lyase (ferrochelatase):Uroporphyrinogen-III decarboxylase:Predicted Fe-S oxidoreductases:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Adenine deaminase:Protoporphyrinogen oxidase:NAD(P)H-nitrite reductase:Cytochrome bd-type quinol oxidase, subunit 1:Cytochrome bd-type quinol oxidase, subunit 2:FOG: WD40-like repeat:Uncharacterized protein required for cytochrome oxidase assembly:Cytochrome c, mono- and diheme variants:Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases:Predicted membrane protein:Signal transduction histidine kinase regulating citrate/malate metabolism:ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components:ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Amino sugar and nucleotide sugar metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:hemH:cydB:proto_IX_ox:hemE:cyoE_ctaB:nitri_red_nirB:nirD_assim_sml:CydD:CydC:integ_memb_HG:rSAM_more_4Fe4S:Information storage and processing:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Unknown function:Electron transport:Energy metabolism:Nitrogen metabolism:Central intermediary metabolism:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling" 190 "Arginase/agmatinase/formimionoglutamate hydrolase, arginase family:CTP synthase (UTP-ammonia lyase):Superfamily II DNA/RNA helicases, SNF2 family:ABC-type antimicrobial peptide transport system, permease component:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Amino acid transporters:Na+/alanine symporter:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:ABC-type multidrug transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:NAD(FAD)-utilizing enzyme possibly involved in translation:Flagellar motor component:Predicted transcriptional regulators:Predicted Na+/dicarboxylate symporter:FOG: GGDEF domain:Permeases:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell motility:Inorganic ion transport and metabolism:Pyrimidine metabolism:Arginine and proline metabolism:Histidine metabolism:Tyrosine metabolism:Selenocompound metabolism:Polycyclic aromatic hydrocarbon degradation:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Signal transduction mechanisms:gid_trmFO:GGDEF:PyrG:rumA:agcS:agmatinase:rSAM_HemZ:Defense mechanisms:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:tRNA and rRNA base modification:Protein synthesis:Pyrimidine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Cellular processes and signaling:Nucleotide Metabolism:Metabolism:Poorly characterized:Information storage and processing:Other:Signal transduction" 191 "Diaminopimelate decarboxylase:Riboflavin synthase beta-chain:3,4-dihydroxy-2-butanone 4-phosphate synthase:Riboflavin synthase alpha chain:DNA primase (bacterial type):Predicted transcriptional regulators:Endonuclease IV:Preprotein translocase subunit SecE:Na+-dependent transporters of the SNF family:ABC-type metal ion transport system, ATPase component:Predicted Fe-S oxidoreductase:Predicted membrane protein, hemolysin III homolog:Transcriptional regulator:Recombinational DNA repair protein (RecF pathway):Predicted transcriptional regulators:Predicted transcriptional regulators:Transcriptional regulators:Pyrimidine reductase, riboflavin biosynthesis:ABC-type metal ion transport system, permease component:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Cyanate permease:Uncharacterized conserved protein:ACT domain-containing protein:Predicted integral membrane protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Lysine biosynthesis:Histidine metabolism:Tyrosine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Selenocompound metabolism:Polycyclic aromatic hydrocarbon degradation:Riboflavin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:DNA replication:Protein export:Bacterial secretion system:Base excision repair:Homologous recombination:General function prediction only:Function unknown:lumazine-synth:parB_part:ribE:ribD_Cterm:rumA:ribA:nfo:reco:CynX:secE_bact:lysA:hlyIII:TIGR01212:dnaG:Intracellular trafficking, secretion, and vesicular transport:Global:Signal Transduction:Metabolism:Membrane Transport:Environmental Information Processing:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:DNA replication, recombination, and repair:Amino Acid Metabolism:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Other:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:DNA metabolism:Metabolism" 192 "Energy production and conversion:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Ketol-acid reductoisomerase:3-isopropylmalate dehydratase large subunit:3-isopropylmalate dehydratase small subunit:Homoserine kinase:Isopropylmalate/homocitrate/citramalate synthases:Dethiobiotin synthetase:7-keto-8-aminopelargonate synthetase and related enzymes:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Acetolactate synthase, small (regulatory) subunit:Homoserine dehydrogenase:Isocitrate/isopropylmalate dehydrogenase:Threonine synthase:Biotin synthase and related enzymes:Pyruvate carboxylase:Pimeloyl-CoA synthetase:Cytochrome P450:Amino acid transport and metabolism:Coenzyme transport and metabolism:Citrate cycle (TCA cycle):Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Bisphenol degradation:Pyruvate metabolism:Polycyclic aromatic hydrocarbon degradation:Aminobenzoate degradation:Butanoate metabolism:C5-Branched dibasic acid metabolism:Vitamin B6 metabolism:Pantothenate and CoA biosynthesis:Biotin metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:acolac_lg:acolac_sm:leuB:leuC:leuD:thrB:thrC:bioD:bioB:ilvC:bioA:bioF:leuA_bact:bioW:pyruv_carbox:Amino acid biosynthesis:Glycolysis/gluconeogenesis:Energy metabolism:Metabolism:Global:Xenobiotics Biodegradation and Metabolism:Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Metabolism:Carbohydrate Metabolism:Biotin:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyruvate family:Aspartate family" 193 "Energy production and conversion:EMAP domain:Cytidylate kinase:Predicted metal-dependent hydrolase:Spermidine synthase:Thiol-disulfide isomerase and thioredoxins:Ribosomal protein S1:Single-stranded DNA-specific exonuclease:Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit:tmRNA-binding protein:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:Bacterial cell division membrane protein:Diacylglycerol kinase:Multisubunit Na+/H+ antiporter, MnhC subunit:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog):L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases:Multisubunit Na+/H+ antiporter, MnhG subunit:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Multisubunit Na+/H+ antiporter, MnhE subunit:D-alanyl-D-alanine carboxypeptidase:Multisubunit Na+/H+ antiporter, MnhB subunit:Multisubunit Na+/H+ antiporter, MnhF subunit:Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:beta-Alanine metabolism:Glutathione metabolism:Peptidoglycan biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:RNA polymerase:Base excision repair:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:cmk:TIGR00043:smpB:speE:mazG:recJ:2a6301s01:2a6301s02:2a6301s04:murG:CPA3_mnhG_phaG:IPP_isom_2:sigma70-ECF:Poorly characterized:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Transcription:Translation:Replication and Repair:Global:Metabolism:Central intermediary metabolism:Polyamine biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Other:Transport and binding proteins:Cations and iron carrying compounds:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 194 "Energy production and conversion:Predicted sugar kinase:3-phosphoglycerate kinase:Enolase:Triosephosphate isomerase:Glucose-6-phosphate isomerase:Transaldolase:Fructose/tagatose bisphosphate aldolase:6-phosphofructokinase:Predicted enzyme with a TIM-barrel fold:6-phosphogluconate dehydrogenase:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:Phosphoglyceromutase:Amidases related to nicotinamidase:Uncharacterized protein conserved in bacteria:Nicotinic acid phosphoribosyltransferase:Uncharacterized conserved protein:Di- and tripeptidases:Uncharacterized conserved protein, contains S4-like domain:Uncharacterized protein conserved in bacteria:Negative regulator of septation ring formation:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Pentose phosphate pathway:Fructose and mannose metabolism:Galactose metabolism:Purine metabolism:Glutathione metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Inositol phosphate metabolism:Pyruvate metabolism:Methane metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00044:cbbA:tim:TIGR00726:gnd:fsa_talC_mipB:eno:pgm_bpd_ind:NAPRTase_put:PepT-like:PFKA_ATP:Nucleotide Metabolism:Energy Metabolism:Glycolysis/gluconeogenesis:Carbohydrate Metabolism:Pentose phosphate pathway:Unknown function:Enzymes of unknown specificity:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Cellular processes and signaling:Metabolism:Poorly characterized:Energy metabolism:Metabolism:Global:Folding Sorting and Degradation:Genetic Information Processing:Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids" 195 "Acetyltransferase (isoleucine patch superfamily):Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Glycosyltransferase:Glycosyltransferases involved in cell wall biogenesis:Nucleoside phosphorylase:Predicted nucleoside-diphosphate sugar epimerases:Predicted glycosyltransferases:Sugar transferases involved in lipopolysaccharide synthesis:Methylase involved in ubiquinone/menaquinone biosynthesis:Exopolysaccharide biosynthesis protein:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cysteine and methionine metabolism:Metabolic pathways:Protein export:General function prediction only:MTA/SAH-Nsdase:sigpep_I_arch:NeuD_NnaD:YqxM_for_SipW:cognate_SipW:Metabolism:Amino Acid Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:Cellular processes and signaling:Metabolism:Poorly characterized" 196 "Ribosomal protein S3:Ribosomal protein L14:Ribosomal protein L5:Ribosomal protein S8:Ribosomal protein L6P/L9E:Ribosomal protein S5:Ribosomal protein S17:Ribosomal protein L16/L10E:Ribosomal protein L24:Ribosomal protein S14:Ribosomal protein L15:Ribosomal protein L29:Ribosomal protein L18:Adenylate kinase and related kinases:Ribosomal protein L30/L7E:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Purine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:L29:L18_bact:rpsC_bact:rpsE_bact:rplN_bact:rplO_bact:rplX_bact:rplP_bact:rpmD_bact:adk:S17_bact:L6_bact:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide Metabolism:Nucleotide and nucleoside interconversions:Protein synthesis:Ribosomal proteins: synthesis and modification:Information storage and processing:Metabolism:Metabolism:Metabolism:Global:Translation:Genetic Information Processing" 197 "Predicted Co/Zn/Cd cation transporters:Lipoate-protein ligase A:Glycine/serine hydroxymethyltransferase:Ribosomal protein S15P/S13E:Predicted rRNA methylase (SpoU class):Ribosomal protein L28:Ribosomal protein S20:Ribosomal protein S4 and related proteins:Rhodanese-related sulfurtransferase:Bacterial nucleoid DNA-binding protein:Sortase and related acyltransferases:Deoxynucleoside kinases:Transcriptional regulators:Thiamine pyrophosphokinase:Muramidase (flagellum-specific):Uncharacterized proteins, LmbE homologs:DNA-directed RNA polymerase, delta subunit:Capsular polysaccharide biosynthesis protein:Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein):Predicted membrane protein:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cyanoamino acid metabolism:One carbon pool by folate:Methane metabolism:Thiamine metabolism:Lipoic acid metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:RNA polymerase:Function unknown:L28:S20:rRNA_methyl_2:S15_bact:rpsD_bact:CDF:thi_PPkinase:thiol_BshB2:Intracellular trafficking, secretion, and vesicular transport:Protein synthesis:Metabolism:Global:Metabolism:Translation:Transcription:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Metabolism:Energy Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing:Thiamine:Glutathione and analogs:Biosynthesis of cofactors, prosthetic groups, and carriers:Cations and iron carrying compounds:Transport and binding proteins:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification" 198 "ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Putative Ser protein kinase:Mn-containing catalase:Uncharacterized conserved protein:Amino acid transport and metabolism:Inorganic ion transport and metabolism:ABC transporters:Function unknown:Signal transduction mechanisms:HEQRo_perm_3TM:spore_gerQ:spore_IV_A:spore_III_D:spore_ytfJ:spore_ysxE:Sporulation and germination:Membrane Transport:Transport and binding proteins:Amino acids, peptides and amines:Cellular processes:Environmental Information Processing:Cellular processes and signaling:Metabolism:Poorly characterized" 199 "Prephenate dehydratase:tRNA delta(2)-isopentenylpyrophosphate transferase:Predicted amidohydrolase:Aspartate/tyrosine/aromatic aminotransferase:Permeases of the drug/metabolite transporter (DMT) superfamily:Amino acid transporters:Gamma-aminobutyrate permease and related permeases:Transcription termination factor:Putative threonine efflux protein:Predicted small molecule binding protein (contains 3H domain):Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC:Transcriptional regulators:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Zn-dependent carboxypeptidase:Signal transduction histidine kinase:Predicted membrane protein:Uncharacterized small protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cysteine and methionine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:RNA degradation:General function prediction only:Function unknown:Signal transduction mechanisms:miaA:rho:2A76:DivI1A_domain:Protein synthesis:Transcription factors:Transcription:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Poorly characterized:Amino Acid Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Amino acids, peptides and amines:Transport and binding proteins:tRNA and rRNA base modification" 200 "Energy production and conversion:Ribosomal protein S14:L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D:Ribosomal protein L33:Acetyltransferases:Pseudouridylate synthases, 23S RNA-specific:Transcriptional regulator:Permeases of the drug/metabolite transporter (DMT) superfamily:Nitroreductase:Predicted transcriptional regulators:Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis:Ribonuclease HIII:Predicted sulfurtransferase:Predicted transcriptional regulators:Transcriptional regulators:Membrane transporters of cations and cationic drugs:Uncharacterized protein conserved in bacteria:Phage-related replication protein:DNA alkylation repair enzyme:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Cyanoamino acid metabolism:Terpenoid backbone biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:DNA replication:General function prediction only:Function unknown:rluA_subfam:asnASE_II:ispG_gcpE:rnhC:rpmG_bact:SASP_sspL:DNA metabolism:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Replication and Repair:Translation:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Sporulation and germination:Energy Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Metabolism:Poorly characterized:Cellular processes:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification:Protein synthesis:DNA replication, recombination, and repair" 201 "Predicted Co/Zn/Cd cation transporters:Molybdenum cofactor biosynthesis enzyme:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Zn-dependent protease with chaperone function:Sec-independent protein secretion pathway component TatC:Gamma-aminobutyrate permease and related permeases:Predicted CoA-binding protein:Transcriptional regulator/sugar kinase:Putative homoserine kinase type II (protein kinase fold):AT-rich DNA-binding protein:Putative ammonia monooxygenase:Predicted HD-superfamily hydrolase:Membrane protein involved in cytochrome C biogenesis:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid metabolism:Metabolic pathways:Protein export:Bacterial secretion system:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:moaC:tatC:CDF:GABAperm:Gneg_AbrB_dup:Intracellular trafficking, secretion, and vesicular transport:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Information storage and processing:Lipid Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Molybdopterin:Biosynthesis of cofactors, prosthetic groups, and carriers:Cations and iron carrying compounds:Amino acids, peptides and amines" 202 "Glutamate 5-kinase:Pyrroline-5-carboxylate reductase:Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels:Signal transduction histidine kinase:Protease subunit of ATP-dependent Clp proteases:Gamma-aminobutyrate permease and related permeases:Flagellar motor protein:Predicted transcriptional regulators:DnaK suppressor protein:Predicted SAM-dependent methyltransferase:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Phage-related replication protein:Amino acid transport and metabolism:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Arginine and proline metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:proC:YbgI_SA1388:proB:Intracellular trafficking, secretion, and vesicular transport:Amino Acid Metabolism:Glutamate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:General:Unknown function:Metabolism:Global:Cell Motility:Cellular Processes:Amino acid biosynthesis" 203 "Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases:Predicted redox protein, regulator of disulfide bond formation:Predicted membrane protein:Mn-containing catalase:ABC-type sugar transport system, auxiliary component:Uncharacterized stress protein (general stress protein 26):Uncharacterized protein conserved in bacteria:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:organ_hyd_perox:Cellular processes and signaling:Detoxification:Cellular processes:Poorly characterized:Metabolism" 204 "NAD-dependent DNA ligase (contains BRCT domain type II):Membrane GTPase LepA:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Superfamily II DNA and RNA helicases:DNA polymerase sliding clamp subunit (PCNA homolog):Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Endonuclease IV:UDP-N-acetylmuramate-alanine ligase:Uncharacterized homolog of plant Iojap protein:Predicted GTPases:Predicted RNA-binding protein containing KH domain, possibly ribosomal protein:ABC-type polysaccharide/polyol phosphate export systems, permease component:Predicted HD superfamily hydrolase involved in NAD metabolism:Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Purine metabolism:Pyrimidine metabolism:D-Glutamine and D-glutamate metabolism:Peptidoglycan biosynthesis:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:iojap_ybeB:small_GTP:RNA_bind_YhbY:TIGR00488:hemN_rel:dnlj:nfo:dnan:murC:apt:T7_EssCb_Firm:Cell envelope:Nucleotide Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking:Unknown function:Enzymes of unknown specificity:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 205 "Predicted Co/Zn/Cd cation transporters:HD superfamily phosphohydrolases:ABC-type multidrug transport system, ATPase and permease components:Mn2+ and Fe2+ transporters of the NRAMP family:Zinc metalloprotease (elastase):Pectate lyase:Sporulation control protein:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Two-component system:General function prediction only:Signal transduction mechanisms:sensory_box:2A0309:nramp:CDF:phage_XkdX:Defense mechanisms:Prophage functions:Carbohydrate Metabolism:Environmental Information Processing:Signal Transduction:Regulatory functions:Small molecule interactions:Transport and binding proteins:Amino acids, peptides and amines:Cations and iron carrying compounds:Mobile and extrachromosomal element functions:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 206 "Energy production and conversion:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Glutaredoxin and related proteins:Lysine efflux permease:Uncharacterized membrane protein:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Formate/nitrite family of transporters:Uncharacterized conserved protein:Predicted transcriptional regulator containing CBS domains:Holliday junction resolvase:Phage-related holin (Lysis protein):N-acetylmuramoyl-L-alanine amidase:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:RNA polymerase:General function prediction only:Function unknown:fnt:holin_tox_secr:phage_XkdX:spo_II_M:sigma70-ECF:Transcription:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Genetic Information Processing:Mobile and extrachromosomal element functions:Sporulation and germination:Cellular processes:Anions:Transport and binding proteins:Prophage functions" 207 "Molecular chaperone (small heat shock protein):Cytochrome c biogenesis protein:Sec-independent protein secretion pathway component TatC:Site-specific recombinases, DNA invertase Pin homologs:SOS-response transcriptional repressors (RecA-mediated autopeptidases):AT-rich DNA-binding protein:Predicted phosphohydrolase (DHH superfamily):Putative ammonia monooxygenase:Spore coat assembly protein:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Protein export:Bacterial secretion system:General function prediction only:Signal transduction mechanisms:lexA:tatC:tatAE:spore_V_K:Gneg_AbrB_dup:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Regulatory functions:DNA interactions:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Sporulation and germination:Information storage and processing:Genetic Information Processing:Poorly characterized" 208 "3-polyprenyl-4-hydroxybenzoate decarboxylase:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Predicted permease:Sulfate permease and related transporters (MFS superfamily):NAD-dependent protein deacetylases, SIR2 family:DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog:Glycerol-3-phosphate responsive antiterminator (mRNA-binding):Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase):Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Endonuclease I:PEP phosphonomutase and related enzymes:Transcriptional antiterminator:Sortase (surface protein transpeptidase):Predicted metal-dependent enzyme:Predicted membrane protein:Response regulator of citrate/malate metabolism:Uncharacterized protein with a bacterial SH3 domain homologue:Uncharacterized protein conserved in bacteria:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:RNA polymerase:General function prediction only:Function unknown:Signal transduction mechanisms:ubiX_pad:pyro_pdase:sulP:sortase_fam:yxeA_fam:prpB:rpoN_sigma:spore_0_A:Unknown function:Carbohydrate Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Environmental Information Processing:Signal Transduction:Global:Metabolism:Transcription:Transcription factors:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Anions:Cellular processes:Sporulation and germination:Hypothetical proteins:Conserved:Metabolism:Enzymes of unknown specificity:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 209 "Micrococcal nuclease (thermonuclease) homologs:Acetyltransferases, including N-acetylases of ribosomal proteins:Site-specific recombinases, DNA invertase Pin homologs:Aminoglycoside N3'-acetyltransferase:Uncharacterized conserved protein:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Function unknown:Defense mechanisms:Information storage and processing:Poorly characterized:Cellular processes and signaling" 210 "Energy production and conversion:Glycosidases:Predicted phosphatase/phosphohexomutase:Predicted dehydrogenases and related proteins:Rieske Fe-S protein:Heme/copper-type cytochrome/quinol oxidases, subunit 1:ABC-type sugar transport systems, permease components:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases:Trehalose and maltose hydrolases (possible phosphorylases):Heme/copper-type cytochrome/quinol oxidases, subunit 2:Transcriptional regulators:Heme/copper-type cytochrome/quinol oxidase, subunit 3:Cytochrome c, mono- and diheme variants:Maltose-binding periplasmic proteins/domains:Heme/copper-type cytochrome/quinol oxidase, subunit 4:Predicted membrane protein:ABC-type maltose transport systems, permease component:Predicted integral membrane protein:Carbohydrate transport and metabolism:Transcription:Glycolysis / Gluconeogenesis:Oxidative phosphorylation:Starch and sucrose metabolism:Streptomycin biosynthesis:Inositol phosphate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Bacterial chemotaxis:Phosphotransferase system (PTS):General function prediction only:Function unknown:EIIB_glc:HAD-SF-IA-v3:caa3_CtaG:CoxB:CtaD_CoxA:CoxD_Bacillus:Signal transduction:Enzymes of unknown specificity:Unknown function:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Membrane Transport:Environmental Information Processing:Biosynthesis of Other Secondary Metabolites:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Information storage and processing:PTS" 211 "Superfamily I DNA and RNA helicases:NAD-dependent DNA ligase (contains BRCT domain type II):Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division:NAD/FAD-utilizing enzyme apparently involved in cell division:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:Predicted GTPase:Predicted Fe-S oxidoreductases:Deoxyxylulose-5-phosphate synthase:Predicted GTPases:Predicted rRNA methylase:Mismatch repair ATPase (MutS family):Metal-dependent hydrolases of the beta-lactamase superfamily I:DNA polymerase IV (family X):Tfp pilus assembly protein PilF:Predicted membrane protein:Cell cycle control, cell division, chromosome partitioning:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:Sulfur relay system:General function prediction only:Function unknown:gidA:gidB:dxs:small_GTP:trmU:tly:dnlj:mutS2:pcrA:Intracellular trafficking, secretion, and vesicular transport:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:DNA replication, recombination, and repair:Metabolism of Terpenoids and Polyketides:Protein synthesis:tRNA and rRNA base modification:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Other:DNA metabolism:Metabolism:Global:Metabolism" 212 "Ribosomal protein S16:Transcription antiterminator:Glycosyltransferase:Signal recognition particle GTPase:Uncharacterized membrane-associated protein:Septum formation inhibitor:Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain:Isochorismate synthase:Phosphatidylserine synthase:Predicted membrane GTPase involved in stress response:Predicted RNA-binding protein (contains KH domain):Growth inhibitor:Uncharacterized protein conserved in bacteria:Septum formation inhibitor-activating ATPase:Cell cycle control, cell division, chromosome partitioning:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Ubiquinone and other terpenoid-quinone biosynthesis:Glycine serine and threonine metabolism:Glycerophospholipid metabolism:Biosynthesis of siderophore group nonribosomal peptides:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:S16:small_GTP:pssA:isochor_syn:nusG:ffh:minC:minD_bact:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Transcription:Transcription factors:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Cell division:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 213 "DNA repair exonuclease:Predicted sugar phosphatases of the HAD superfamily:Transcriptional regulators:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Function unknown:HAD-SF-IIA-hyp2:spo_yunB:Metabolism:Information storage and processing:Enzymes of unknown specificity:Unknown function:Sporulation and germination:Cellular processes:Poorly characterized" 214 "Predicted transcriptional regulators:Site-specific recombinase XerC:Transcription:Replication, recombination and repair:Information storage and processing" 215 "Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Predicted hydrolase (HAD superfamily):Uncharacterized protein conserved in bacteria:Sec-independent protein secretion pathway components:FOG: GGDEF domain:Permeases of the major facilitator superfamily:Regulator of polyketide synthase expression:Arabinose efflux permease:Signal transduction histidine kinase, nitrogen specific:Uncharacterized protein conserved in bacteria:Carbohydrate transport and metabolism:Transcription:Chloroalkane and chloroalkene degradation:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:GGDEF:DegV:SP:tatAE:HAD-SF-IA-v1:excise:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Unknown function:Enzymes of unknown specificity:General:Signal transduction:Other:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 216 "5'-3' exonuclease (including N-terminal domain of PolI):Transcriptional regulator:Cytidylyltransferase:Predicted transcriptional regulators:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Uncharacterized membrane protein, required for colicin V production:Transcriptional regulator:Predicted transcriptional regulators:Acetyltransferases, including N-acetylases of ribosomal proteins:Predicted transcriptional regulators:Transcriptional regulators:Uncharacterized protein conserved in bacteria:AraC-type DNA-binding domain-containing proteins:Uncharacterized conserved protein:Arabinose efflux permease:Uncharacterized conserved protein:Uncharacterized integral membrane protein:Cell wall hydrolyses involved in spore germination:Negative regulator of genetic competence, sporulation and motility:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Glycerophospholipid metabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:YbaK_EbsC:cyt_tran_rel:Unknown function:Lipid Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:General" 217 "Energy production and conversion:NAD-dependent aldehyde dehydrogenases:Threonine dehydrogenase and related Zn-dependent dehydrogenases:Site-specific recombinases, DNA invertase Pin homologs:Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Replication, recombination and repair:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Fatty acid metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:Cyanoamino acid metabolism:Starch and sucrose metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Propanoate metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:tdh:spo_yunB:toxin_SdpC:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Metabolism:Xenobiotics Biodegradation and Metabolism:Carbohydrate Metabolism:Global:Metabolism:Energy metabolism:Amino acids and amines:Cellular processes:Sporulation and germination:Information storage and processing:Metabolism:Poorly characterized" 218 "Energy production and conversion:ABC-type Fe3+-siderophore transport system, permease component:ABC-type Fe3+-hydroxamate transport system, periplasmic component:Flavodoxins:Non-ribosomal peptide synthetase modules and related proteins:Peptide arylation enzymes:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:Isochorismate synthase:Isochorismate hydrolase:Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides:Predicted hydrolase of the alpha/beta superfamily:Coenzyme transport and metabolism:Lipid transport and metabolism:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Biosynthesis of siderophore group nonribosomal peptides:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:isochor_syn:AA-adenyl-dom:flav_short:DHB_AMP_lig:Poorly characterized:Metabolism:Menaquinone and ubiquinone:Biosynthesis of cofactors, prosthetic groups, and carriers:Cations and iron carrying compounds:Transport and binding proteins:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins" 219 "Energy production and conversion:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Signal transduction histidine kinase:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Amino acid transporters:Uncharacterized ABC-type transport system, permease component:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:Acetyltransferases, including N-acetylases of ribosomal proteins:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Transcriptional accessory protein:Sugar phosphate permease:ABC-type uncharacterized transport systems, ATPase components:Signal transduction histidine kinase, nitrogen specific:Transcriptional antiterminator:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Citrate cycle (TCA cycle):Oxidative phosphorylation:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Signal transduction mechanisms:sensory_box:dhsB:Regulatory functions:TCA cycle:Energy metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Metabolism:Global:Poorly characterized:Signal Transduction:Environmental Information Processing:Energy Metabolism:Small molecule interactions:Carbohydrate Metabolism" 220 "Energy production and conversion:Carbonic anhydrase:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Phosphate starvation-inducible protein PhoH, predicted ATPase:Sporulation protein and related proteins:Cell cycle control, cell division, chromosome partitioning:Transcription:Inorganic ion transport and metabolism:Oxidative phosphorylation:Metabolic pathways:RNA polymerase:Signal transduction mechanisms:SASP_gamma:RpoD_Cterm:SpoIID_LytB:Sporulation and germination:Energy Metabolism:Genetic Information Processing:Transcription:Global:Metabolism:Transcription:Transcription factors:Cellular processes:Metabolism:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism" 221 "Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:Putative translation initiation inhibitor, yjgF family:Predicted metal-dependent hydrolase:Queuine/archaeosine tRNA-ribosyltransferase:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Holliday junction resolvasome, DNA-binding subunit:S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase):Recombinational DNA repair ATPase (RecF pathway):Predicted membrane-associated HD superfamily hydrolase:Exonuclease VII, large subunit:Preprotein translocase subunit YajC:4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase:Holliday junction resolvasome, helicase subunit:Uncharacterized conserved protein:ACT domain-containing protein:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Phenylalanine tyrosine and tryptophan biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Protein export:Bacterial secretion system:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:TIGR00004:TIGR00043:ruvA:queA:ispE:xseA:HDIG:Q_tRNA_tgt:recf:ruvB:yajC:gyrB:gyrA:purR_Bsub:YaaA_near_RecF:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Regulatory functions:DNA interactions:DNA metabolism:Degradation of DNA:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Protein synthesis:Other:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Biosynthesis of cofactors, prosthetic groups, and carriers:Other" 222 "Energy production and conversion:Methylated DNA-protein cysteine methyltransferase:Zn-dependent hydrolases, including glyoxylases:Sugar kinases, ribokinase family:Peroxiredoxin:Hemolysins and related proteins containing CBS domains:Na+/H+-dicarboxylate symporters:Subtilisin-like serine proteases:Predicted transcriptional regulator:Di- and tripeptidases:Sugar phosphate permease:Uncharacterized conserved protein:Uncharacterized distant relative of cell wall-associated hydrolases:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Fructose and mannose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:General function prediction only:Function unknown:ogt:rrf2_super:peptidase-T:Poorly characterized:Carbohydrate Metabolism:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Degradation of proteins, peptides, and glycopeptides:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 223 "Integrase:Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster:Transcriptional regulators:Phosphotransferase system IIA components:Lysophospholipase L1 and related esterases:Predicted Zn peptidase:Predicted exonuclease:DNA gyrase inhibitor:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Glycolysis / Gluconeogenesis:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Phosphotransferase system (PTS):General function prediction only:Function unknown:PTBA:Metabolism:Carbohydrate Metabolism:Poorly characterized:Metabolism:Information storage and processing:PTS:Signal transduction:Membrane Transport:Environmental Information Processing" 224 "ADP-glucose pyrophosphorylase:Superoxide dismutase:ABC-type amino acid transport system, permease component:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type polar amino acid transport system, ATPase component:Acyl-CoA dehydrogenases:Uncharacterized conserved protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Inorganic ion transport and metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:HEQRo_perm_3TM:glgC:spore_III_AG:spore_II_P:spore_ytfJ:DNA_bind_RsfA:Amino acids, peptides and amines:Carbohydrate Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Transport and binding proteins:Metabolism:Cellular processes:Sporulation and germination:Metabolism:Poorly characterized" 225 "tRNA-dihydrouridine synthase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Thymidylate kinase:Anthranilate/para-aminobenzoate synthases component I:Dihydropteroate synthase and related enzymes:Predicted methyltransferases:Guanosine polyphosphate pyrophosphohydrolases/synthetases:Anthranilate/para-aminobenzoate synthases component II:Superfamily II DNA and RNA helicases:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase:Phosphomannomutase:Lysyl-tRNA synthetase (class II):Dihydroneopterin aldolase:Uncharacterized stress-induced protein:Uncharacterized homolog of PSP1:Transcriptional regulators:Arginine/lysine/ornithine decarboxylases:Sugar phosphate permease:Predicted endonuclease containing a URI domain:Predicted O-methyltransferase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Purine metabolism:Pyrimidine metabolism:Amino sugar and nucleotide sugar metabolism:Folate biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:General function prediction only:Function unknown:Signal transduction mechanisms:DTMP_kinase:TIGR00096:TIGR00255:lysS_bact:folB:trpG_papA:spoT_relA:efflux_EmrB:nifR3_yhdG:glmM:DHPS:folK:Enzymes of unknown specificity:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Global:Metabolism:Central intermediary metabolism:Amino sugars:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Other:Cellular processes:Adaptations to atypical conditions:Hypothetical proteins:Conserved:Unknown function:Metabolism:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 226 "Energy production and conversion:5'-3' exonuclease (including N-terminal domain of PolI):Nucleotidyltransferase/DNA polymerase involved in DNA repair:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:Transcriptional regulator:NADPH:quinone reductase and related Zn-dependent oxidoreductases:Cytidylyltransferase:Preprotein translocase subunit SecE:Putative intracellular protease/amidase:Preprotein translocase subunit YidC:Fe2+/Zn2+ uptake regulation proteins:Penicillin tolerance protein:Gamma-aminobutyrate permease and related permeases:Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain:Predicted metal-dependent membrane protease:Uncharacterized membrane protein, required for colicin V production:Predicted phosphohydrolases:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Uncharacterized conserved protein:Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC:Teichoic acid biosynthesis proteins:Homocysteine/selenocysteine methylase (S-methylmethionine-dependent):Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Glycerophospholipid metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:cyt_tran_rel:ispH_lytB:wecG_tagA_cpsF:secE_bact:yidC_oxa1_cterm:Intracellular trafficking, secretion, and vesicular transport:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Cellular processes and signaling:Lipid Metabolism:Metabolism:Poorly characterized:Information storage and processing:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Protein and peptide secretion and trafficking:Metabolism:Protein fate:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation" 227 "Ribonucleotide reductase, beta subunit:Ribonucleotide reductase, alpha subunit:Ketopantoate hydroxymethyltransferase:Panthothenate synthetase:SAM-dependent methyltransferases:Predicted GTPase:Uridine kinase:Phosphatidylserine decarboxylase:MoxR-like ATPases:Cation/multidrug efflux pump:Aspartate 1-decarboxylase:ABC-type polysaccharide/polyol phosphate transport system, ATPase component:Rad3-related DNA helicases:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Protein involved in ribonucleotide reduction:Predicted phosphoesterase (MutT family):Protein involved in sex pheromone biosynthesis:Site-specific recombinase XerD:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Purine metabolism:Pyrimidine metabolism:beta-Alanine metabolism:Glycerophospholipid metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:panC:PS_decarb:panB:panD:small_GTP:udk:nrdI:dnaq:recomb_XerC:NrdE_NrdA:Defense mechanisms:Degradation of DNA:DNA metabolism:2'-Deoxyribonucleotide metabolism:Salvage of nucleosides and nucleotides:Purines, pyrimidines, nucleosides, and nucleotides:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Nucleotide Metabolism:Pantothenate and coenzyme A:Lipid Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Unknown function:DNA replication, recombination, and repair" 228 "Energy production and conversion:Protein chain release factor A:Dephospho-CoA kinase:Dihydrofolate reductase:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Malic enzyme:GTP cyclohydrolase I:DNA mismatch repair enzyme (predicted ATPase):Uncharacterized conserved protein:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:RecG-like helicase:Predicted transcriptional regulators:DNA replication protein:Cell division septal protein:Na+/H+ antiporter:L-serine deaminase:Predicted transcriptional regulator:Predicted membrane protein:Signal transduction histidine kinase regulating citrate/malate metabolism:Replication initiation/membrane attachment protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Pyruvate metabolism:One carbon pool by folate:Methane metabolism:Thiamine metabolism:Pantothenate and CoA biosynthesis:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Mismatch repair:Homologous recombination:Sulfur relay system:Function unknown:Signal transduction mechanisms:prfB:folE:TIGR00152:parB_part:mutl:recG:sda_alpha:sda_beta:rrf2_super:antiport_nhaC:spore_YtaF:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Translation factors:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Sporulation and germination:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 229 "Energy production and conversion:Arginase/agmatinase/formimionoglutamate hydrolase, arginase family:2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway):Molecular chaperone, HSP90 family:Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain:Acetyltransferases:Proline dehydrogenase:Amino acid transporters:NAD-dependent aldehyde dehydrogenases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Ornithine/acetylornithine aminotransferase:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Fatty acid biosynthesis:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:sensory_box:rocF_arginase:D1pyr5carbox2:DAHP_synth_Bsub:Orn_aminotrans:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Amino Acid Metabolism:Cellular processes and signaling:Lipid Metabolism:Metabolism:Poorly characterized:Information storage and processing:Aromatic amino acid family:Amino acid biosynthesis:Small molecule interactions:Regulatory functions" 230 "Isopropylmalate/homocitrate/citramalate synthases:Acetyl-CoA acetyltransferase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Enoyl-CoA hydratase/carnithine racemase:3-hydroxyacyl-CoA dehydrogenase:Acetyl/propionyl-CoA carboxylase, alpha subunit:Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta):Amino acid transport and metabolism:Lipid transport and metabolism:Fatty acid biosynthesis:Fatty acid metabolism:Synthesis and degradation of ketone bodies:Valine leucine and isoleucine degradation:Geraniol degradation:Lysine degradation:Arginine and proline metabolism:Benzoate degradation:Tryptophan metabolism:beta-Alanine metabolism:Pyruvate metabolism:Aminobenzoate degradation:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Terpenoid backbone biosynthesis:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:DapE-ArgE:AcCoA-C-Actrans:spore_III_AC:spore_III_AD:GNAT_ablB:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Metabolism:Energy Metabolism:Environmental Information Processing:Carbohydrate Metabolism:Signal Transduction:Global:Metabolism:Fatty acid and phospholipid metabolism:Other:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Sporulation and germination:Metabolism:Xenobiotics Biodegradation and Metabolism" 231 "Dihydroorotase and related cyclic amidohydrolases:4-aminobutyrate aminotransferase and related aminotransferases:Predicted Na+-dependent transporter:Acetyltransferases:Sugar kinases, ribokinase family:Predicted permease:Signal peptidase I:3-dehydroquinate dehydratase:Predicted 6-phosphogluconate dehydrogenase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Hydrolases of the alpha/beta superfamily:Subtilisin-like serine proteases:Dipeptidyl aminopeptidases/acylaminoacyl-peptidases:Beta-fructosidases (levanase/invertase):Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family:Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit:Uncharacterized MobA-related protein:Sugar phosphate permease:Transthyretin-like protein:Mn-containing catalase:Uricase (urate oxidase):Transcriptional antiterminator:3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase):Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Fructose and mannose metabolism:Synthesis and degradation of ketone bodies:Purine metabolism:Caffeine metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine degradation:Phenylalanine tyrosine and tryptophan biosynthesis:beta-Alanine metabolism:Glutathione metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Inositol phosphate metabolism:Propanoate metabolism:Butanoate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Protein export:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:GABAtrnsam:gnd_rel:aroD:PHB_DH:sigpep_I_bact:pcaJ_scoB_fam:hdxy_isourate:UHCUDC:allantoinase:pucB:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Folding Sorting and Degradation:Global:Metabolism:Central intermediary metabolism:Other:Energy metabolism:Pentose phosphate pathway:Purines, pyrimidines, nucleosides, and nucleotides:Other:Protein fate:Protein and peptide secretion and trafficking:Amino acid biosynthesis:Aromatic amino acid family:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 232 "Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Bacterial nucleoid DNA-binding protein:Phage-related replication protein:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:General function prediction only:phage_XkdX:tape_meas_TP901:Poorly characterized:Cellular processes and signaling:Information storage and processing:Prophage functions:Mobile and extrachromosomal element functions" 233 "Putative translation factor (SUA5):Pyrroline-5-carboxylate reductase:Lactoylglutathione lyase and related lyases:Thioredoxin reductase:Predicted hydrolases of the HAD superfamily:Transcriptional regulator:Predicted permeases:Uncharacterized protein conserved in bacteria:Panthothenate kinase:ABC-type multidrug transport system, ATPase component:Metal-dependent hydrolases of the beta-lactamase superfamily III:Transcriptional regulator:Preprotein translocase subunit SecG:Mn-dependent transcriptional regulator:Transcriptional regulators:Chromate transport protein ChrA:Transcriptional regulators:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Uncharacterized small membrane protein:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Signal transduction histidine kinase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:Arginine and proline metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00057:Cof-subfamily:DNA_YbaB_EbfC:panK_bact:secG:RNase_Z:TIGR03943:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Cellular processes and signaling:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transcription:RNA processing:Protein fate:Protein and peptide secretion and trafficking:Unknown function:Enzymes of unknown specificity:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 234 "Geranylgeranyl pyrophosphate synthase:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:Single-stranded DNA-specific exonuclease:UDP-N-acetylmuramyl tripeptide synthase:UDP-N-acetylmuramoylalanine-D-glutamate ligase:Bacterial cell division membrane protein:Transcription termination factor:Collagenase and related proteases:Exonuclease VII, large subunit:D-alanyl-D-alanine carboxypeptidase:Exonuclease VII small subunit:16S RNA G1207 methylase RsmC:Predicted O-methyltransferase:Cell cycle control, cell division, chromosome partitioning:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Lysine biosynthesis:D-Glutamine and D-glutamate metabolism:Peptidoglycan biosynthesis:One carbon pool by folate:Carbon fixation pathways in prokaryotes:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Base excision repair:Mismatch repair:Homologous recombination:General function prediction only:xseA:mraY:recJ:murE:murD:xseB:nusB:ftsW:Metabolism:Poorly characterized:DNA metabolism:Metabolism:Global:Metabolism:Replication and Repair:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Degradation of DNA:Energy Metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Cellular processes:Cell division:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling" 235 "ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:Chemotaxis protein CheC, inhibitor of MCP methylation:Translation, ribosomal structure and biogenesis:Cell motility:Inorganic ion transport and metabolism:Bacterial chemotaxis:Signal transduction mechanisms:TIGR00093:Metabolism:Cell Motility:Protein synthesis:tRNA and rRNA base modification:Information storage and processing:Cellular processes and signaling:Cellular Processes" 236 "Uncharacterized conserved protein:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Mg2+ and Co2+ transporters:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Predicted nucleoside-diphosphate sugar epimerase:Hemolysins and related proteins containing CBS domains:Amidases related to nicotinamidase:Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase:Predicted membrane protein:Predicted glycosyl hydrolase:Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain:Lipid transport and metabolism:Inorganic ion transport and metabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00147:TIGR00149_YbjQ:yfcH:Enzymes of unknown specificity:Unknown function:Metabolism:Hypothetical proteins:Poorly characterized:Conserved" 237 "Energy production and conversion:Glutamate-1-semialdehyde aminotransferase:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Delta-aminolevulinic acid dehydratase:Porphobilinogen deaminase:Glutamyl-tRNA reductase:Protein-tyrosine-phosphatase:ABC-type transport system involved in Fe-S cluster assembly, ATPase component:Peroxiredoxin:Selenocysteine lyase:Predicted permease:Preprotein translocase subunit SecA (ATPase, RNA helicase):ABC-type transport system involved in Fe-S cluster assembly, permease component:Catalase:ABC-type transport system involved in cytochrome c biogenesis, permease component:NifU homolog involved in Fe-S cluster formation:Uncharacterized protein required for formate dehydrogenase activity:Uroporphyrinogen-III synthase:Uncharacterized protein conserved in bacteria:Zn-dependent proteases:Transcriptional regulator, contains sigma factor-related N-terminal domain:Molybdenum cofactor biosynthesis enzyme:Alpha-acetolactate decarboxylase:Alkyl hydroperoxide reductase, large subunit:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Valine leucine and isoleucine biosynthesis:Tryptophan metabolism:Selenocompound metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Methane metabolism:Thiamine metabolism:Pantothenate and CoA biosynthesis:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Protein export:Bacterial secretion system:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:fdhD_narQ:hemC:hemL:secA:hemA:acetolac_decarb:GAPDH-I:sufC:sufS:sufB:sufD:SUF_scaf_2:acolac_catab:moaA:AhpC:AhpF:Intracellular trafficking, secretion, and vesicular transport:Adaptations to atypical conditions:Cellular processes:Protein and peptide secretion and trafficking:Protein fate:Glycolysis/gluconeogenesis:Fermentation:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Molybdopterin:Heme, porphyrin, and cobalamin:Other:Biosynthesis of cofactors, prosthetic groups, and carriers" 238 "Energy production and conversion:Malate/lactate dehydrogenases:Malic enzyme:Permeases of the drug/metabolite transporter (DMT) superfamily:Predicted transcriptional regulators:Zn-dependent alcohol dehydrogenases:Nitrate reductase beta subunit:L-lactate permease:Phage terminase large subunit:Nitrate reductase delta subunit:Nitrate reductase gamma subunit:Nitrate/nitrite transporter:Predicted ring-cleavage extradiol dioxygenase:Arabinose efflux permease:Na+/citrate symporter:Inhibitor of the KinA pathway to sporulation, predicted exonuclease:Uncharacterized conserved protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Cysteine and methionine metabolism:Pyruvate metabolism:Propanoate metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:narI:narJ:ccs:lctP:phage_term_2:narH:L-LDH-NAD:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Anaerobic:Glycolysis/gluconeogenesis:Protein fate:Protein folding and stabilization:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Mobile and extrachromosomal element functions:Prophage functions:Unclassified:Role category not yet assigned:Information storage and processing:Metabolism:Metabolism" 239 "Lactoylglutathione lyase and related lyases:Transcriptional regulator:Predicted xylanase/chitin deacetylase:Cell wall-associated hydrolases (invasion-associated proteins):Phosphatidylglycerophosphatase A and related proteins:Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family:Cu/Zn superoxide dismutase:Membrane protein involved in the export of O-antigen and teichoic acid:Uncharacterized protein conserved in bacteria:Phage-related protein:N-acetylmuramoyl-L-alanine amidase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:General function prediction only:Function unknown:spore_YhcN_YlaJ:spore_V_B:spore_yutH:SASP_sspL:Information storage and processing:Sporulation and germination:Cellular processes:Metabolism:Poorly characterized:Cellular processes and signaling" 240 "Superfamily I DNA and RNA helicases:6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase:Sulfite reductase, alpha subunit (flavoprotein):Fructose-2,6-bisphosphatase:Transcriptional regulator:Amino acid transporters:Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Transcriptional regulator:Transcriptional regulator:Deoxynucleoside kinases:Uncharacterized proteins, homologs of lactam utilization protein B:Mn2+ and Fe2+ transporters of the NRAMP family:Large-conductance mechanosensitive channel:Allophanate hydrolase subunit 2:Allophanate hydrolase subunit 1:Predicted acyltransferase:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Fatty acid metabolism:Tryptophan metabolism:Amino sugar and nucleotide sugar metabolism:Aminobenzoate degradation:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Phosphotransferase system (PTS):Nucleotide excision repair:Mismatch repair:General function prediction only:Function unknown:mscL:TIGR00370:nagB:efflux_EmrB:urea_amlyse_rel:EIIB_glc:Cellular processes:Other:Transport and binding proteins:Amino sugars:Central intermediary metabolism:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Adaptations to atypical conditions:Carbohydrate Metabolism:Hypothetical proteins:Conserved:Unknown function:General:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 241 "Energy production and conversion:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Gamma-glutamyltransferase:Acetyltransferases:Carbamoylphosphate synthase large subunit (split gene in MJ):Predicted Fe-S oxidoreductases:Predicted Zn-dependent peptidases:Acetyl-CoA carboxylase beta subunit:Acetyl-CoA carboxylase alpha subunit:ABC-type multidrug transport system, ATPase component:S-adenosylmethionine decarboxylase:Na+/H+ antiporter:Phosphoenolpyruvate carboxykinase (ATP):Xylose isomerase:Uncharacterized small membrane protein:Transcriptional regulator:Predicted permease, DMT superfamily:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Pentose and glucuronate interconversions:Fructose and mannose metabolism:Fatty acid biosynthesis:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Taurine and hypotaurine metabolism:Selenocompound metabolism:Cyanoamino acid metabolism:Glutathione metabolism:Arachidonic acid metabolism:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:g_glut_trans:pckA:accA:accD:antiport_nhaC:2A78:CPSaseII_lrg:GAPDH-I:xylose_isom_A:SAM_DCase_Bsu:rSAM_more_4Fe4S:Defense mechanisms:Cations and iron carrying compounds:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Global:Metabolism:Central intermediary metabolism:Polyamine biosynthesis:Energy metabolism:Glycolysis/gluconeogenesis:Sugars:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Transport and binding proteins:Amino acids, peptides and amines:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Glutathione and analogs:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 242 "Protein involved in ribonucleotide reduction:Penicillin-binding protein-related factor A, putative recombinase:Nucleotide transport and metabolism:General function prediction only:nrdI:Poorly characterized:Metabolism:2'-Deoxyribonucleotide metabolism:Purines, pyrimidines, nucleosides, and nucleotides" 243 "Energy production and conversion:Glutamyl- and glutaminyl-tRNA synthetases:Mg-dependent DNase:Xanthosine triphosphate pyrophosphatase:Methionyl-tRNA synthetase:Molybdopterin biosynthesis enzyme:Molybdopterin converting factor, large subunit:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:ATP-dependent Zn proteases:ATP-dependent Lon protease, bacterial type:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:Molybdopterin biosynthesis enzymes:Predicted phosphoesterase:Molybdopterin-guanine dinucleotide biosynthesis protein A:NAD-dependent aldehyde dehydrogenases:Predicted glycosyltransferases:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Predicted metal-dependent hydrolase with the TIM-barrel fold:Molybdopterin-guanine dinucleotide biosynthesis protein:Anti-sigma regulatory factor (Ser/Thr protein kinase):Serine phosphatase RsbU, regulator of sigma subunit:Xanthine/uracil permeases:Uncharacterized conserved protein:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Fatty acid metabolism:Purine metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:Selenocompound metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Thiamine metabolism:Limonene and pinene degradation:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Sulfur relay system:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00010:yfcE:TIGR00042:mobB:molyb_syn:metG:gltX_bact:lon:FtsH_fam:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Protein fate:Degradation of proteins, peptides, and glycopeptides:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 244 "Energy production and conversion:Aspartyl/asparaginyl-tRNA synthetases:Nuclease subunit of the excinuclease complex:Predicted membrane protein:ATPase components of ABC transporters with duplicated ATPase domains:ABC-type Fe3+-siderophore transport system, permease component:Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:ABC-type multidrug transport system, ATPase component:FOG: HEAT repeat:Glycosyl transferases, related to UDP-glucuronosyltransferase:FOG: GGDEF domain:ATPase related to the helicase subunit of the Holliday junction resolvase:Arginine degradation protein (predicted deacylase):Uncharacterized protein conserved in bacteria:Response regulator of citrate/malate metabolism:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:ABC transporters:Two-component system:Nucleotide excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00023:uvrC:GGDEF:asnS:MGT:spore_ypjB:Defense mechanisms:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism:Replication and Repair:Translation:Genetic Information Processing:Sporulation and germination:Lipid Metabolism:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Toxin production and resistance:Cellular processes:tRNA aminoacylation" 245 "Energy production and conversion:Mismatch repair ATPase (MutS family):Folylpolyglutamate synthase:tRNA-(guanine-N1)-methyltransferase:Valyl-tRNA synthetase:Signal recognition particle GTPase:Phosphatidylglycerophosphate synthase:dsRNA-specific ribonuclease:Thiamine monophosphate kinase:Holliday junction resolvasome, DNA-binding subunit:Phosphopantetheinyl transferase (holo-ACP synthase):3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:Cell division protein FtsI/penicillin-binding protein 2:Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA:Chromosome segregation ATPases:NADH dehydrogenase, FAD-containing subunit:Uncharacterized protein conserved in bacteria:Preprotein translocase subunit YajC:Holliday junction resolvasome, helicase subunit:Cell cycle control, cell division, chromosome partitioning:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Fatty acid biosynthesis:Oxidative phosphorylation:Valine leucine and isoleucine biosynthesis:Glycerophospholipid metabolism:Thiamine metabolism:Pantothenate and CoA biosynthesis:Folate biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Protein export:Bacterial secretion system:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:ftsY:ruvA:trmD:molyb_syn:TIGR00282:valS:acpS:pgsA:ruvB:yajC:mutS1:thiL:folC:fabZ:SMC_prok_B:RNaseIII:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Replication and Repair:Folding Sorting and Degradation:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Chromosome-associated proteins:Transcription:RNA processing:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism" 246 "Energy production and conversion:Arginase/agmatinase/formimionoglutamate hydrolase, arginase family:Gamma-glutamyltransferase:Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit:Predicted membrane-associated Zn-dependent proteases 1:Alanine racemase:Amino acid transporters:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:TRAP-type C4-dicarboxylate transport system, periplasmic component:ABC-type Na+ efflux pump, permease component:Uncharacterized conserved protein:Response regulator of the LytR/AlgR family:Signal transduction histidine kinase regulating citrate/malate metabolism:Putative peptidoglycan-binding domain-containing protein:Mn-containing catalase:Uncharacterized protein conserved in bacteria:ABC-type Na+ transport system, ATPase component:Response regulator of citrate/malate metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Arginine and proline metabolism:Taurine and hypotaurine metabolism:Selenocompound metabolism:Cyanoamino acid metabolism:D-Alanine metabolism:Glutathione metabolism:Glycerophospholipid metabolism:Arachidonic acid metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Function unknown:Signal transduction mechanisms:g_glut_trans:alr:dctP:rocF_arginase:spore_IV_B:spore_SleB:spore_YpeB:spore_YhcN_YlaJ:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Metabolism:Global:Metabolism:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism of Other Amino Acids:Amino Acid Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Lipid Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cell envelope:Glutathione and analogs:Biosynthesis of cofactors, prosthetic groups, and carriers:Sporulation and germination:Cellular processes" 247 "Energy production and conversion:Xaa-Pro aminopeptidase:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit:Glucose-6-phosphate isomerase:Transaldolase:Fructose/tagatose bisphosphate aldolase:Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):Phosphotransacetylase:Aspartate/tyrosine/aromatic aminotransferase:Glycine cleavage system H protein (lipoate-binding):Predicted hydrolases of the HAD superfamily:Signal transduction histidine kinase:Predicted dehydrogenases and related proteins:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit:Inorganic pyrophosphatase/exopolyphosphatase:Amidases related to nicotinamidase:Cellulase M and related proteins:Predicted Rossmann fold nucleotide-binding protein:Predicted pyrophosphatase:Phosphoserine aminotransferase:Predicted membrane protein:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Predicted signal transduction protein containing EAL and modified HD-GYP domains:Uncharacterized protein involved in cation transport:Predicted glycosyl hydrolase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Pentose phosphate pathway:Fructose and mannose metabolism:Oxidative phosphorylation:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Taurine and hypotaurine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Propanoate metabolism:Butanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Vitamin B6 metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:efp:Cof-subfamily:cbbA:gcvH:pta:TIGR00730:fsa_talC_mipB:serC_1:SPP-subfamily:PDH_E1_alph_x:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Global:Metabolism:Energy metabolism:Amino acids and amines:Fermentation:Glycolysis/gluconeogenesis:Pentose phosphate pathway:Pyruvate dehydrogenase:Protein synthesis:Translation factors:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Serine family:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 248 "Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Transcriptional regulator:Phosphomannose isomerase:Beta-fructosidases (levanase/invertase):DNA-binding HTH domain-containing proteins:Carbohydrate transport and metabolism:Transcription:Glycolysis / Gluconeogenesis:Fructose and mannose metabolism:Galactose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Phosphotransferase system (PTS):manA:scrB_fam:Biosynthesis and degradation of polysaccharides:Sugars:Information storage and processing:Metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Energy metabolism:Carbohydrate Metabolism" 249 "Peptide methionine sulfoxide reductase:ABC-type phosphate transport system, periplasmic component:Conserved domain frequently associated with peptide methionine sulfoxide reductase:Protein-tyrosine-phosphatase:ATPases with chaperone activity, ATP-binding subunit:ABC-type phosphate transport system, permease component:ABC-type phosphate transport system, permease component:Universal stress protein UspA and related nucleotide-binding proteins:Predicted transcriptional regulators:Fe2+/Zn2+ uptake regulation proteins:Arsenite efflux pump ACR3 and related permeases:ABC-type phosphate transport system, ATPase component:Transcriptional regulator:Predicted transcriptional regulators:Cation transport ATPase:Uncharacterized conserved protein:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:ABC transporters:Two-component system:Function unknown:Signal transduction mechanisms:TIGR00357:msrA:acr3:3a0107s01c2:3a0107s02c:ATPase_P-type:ptsS_2:phosphate_pstC:arsC_pI258_fam:Information storage and processing:Adaptations to atypical conditions:Detoxification:Cellular processes:Anions:Transport and binding proteins:Environmental Information Processing:Signal Transduction:Poorly characterized:Membrane Transport:Metabolism:Cellular processes and signaling" 250 "Energy production and conversion:Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases:Glycerol dehydrogenase and related enzymes:ABC-type sugar transport system, permease component:Predicted sugar phosphatases of the HAD superfamily:Enoyl-CoA hydratase/carnithine racemase:Ribulose kinase:Sugar phosphate isomerases/epimerases:ABC-type sugar transport systems, permease components:Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases:Transcriptional regulators:ABC-type sugar transport system, periplasmic component:L-arabinose isomerase:Na+/melibiose symporter and related transporters:Predicted signal transduction protein with a C-terminal ATPase domain:Alpha-L-arabinofuranosidase:Predicted symporter:Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Pentose and glucuronate interconversions:Galactose metabolism:Fatty acid metabolism:Valine leucine and isoleucine degradation:Geraniol degradation:Lysine degradation:Benzoate degradation:Tryptophan metabolism:beta-Alanine metabolism:Amino sugar and nucleotide sugar metabolism:Glycerolipid metabolism:Sphingolipid metabolism:Aminobenzoate degradation:Propanoate metabolism:Butanoate metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:General function prediction only:Signal transduction mechanisms:araD:sss:SP:L-ribulokinase:HAD-SF-IIA:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Enzymes of unknown specificity:Unknown function:Cations and iron carrying compounds:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Metabolism:Global:Sugars:Signal Transduction:Energy metabolism:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism" 251 "" 252 "Energy production and conversion:Lipoate-protein ligase A:Nucleoside-diphosphate-sugar epimerases:Predicted hydrolases of the HAD superfamily:NADPH:quinone reductase and related Zn-dependent oxidoreductases:Predicted Zn-dependent peptidases:Predicted phosphatase/phosphohexomutase:Uncharacterized membrane protein (homolog of Drosophila rhomboid):Predicted permeases:5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Phosphomannomutase:Metal-dependent hydrolases of the beta-lactamase superfamily III:Cellulase M and related proteins:Arsenate reductase and related proteins, glutaredoxin family:Uroporphyrinogen-III synthase:Predicted esterase of the alpha-beta hydrolase superfamily:Uncharacterized conserved protein:Leucyl aminopeptidase (aminopeptidase T):Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Galactose metabolism:Fatty acid biosynthesis:Purine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Lipoic acid metabolism:Porphyrin and chlorophyll metabolism:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:lipoyltrans:SPP-subfamily:HAD-SF-IA-v3:arsC_related:oxido_YhdH:Metabolism:Cellular processes and signaling:Enzymes of unknown specificity:Unknown function:Protein modification and repair:Protein fate:DNA interactions:Regulatory functions:Metabolism:Metabolism:Global:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Lipid Metabolism:Poorly characterized:Carbohydrate Metabolism" 253 "6-phosphofructokinase:Translation elongation factor Ts:Prolyl-tRNA synthetase:Pyruvate kinase:FOG: CBS domain:FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor):CDP-diglyceride synthetase:Predicted Zn-dependent peptidases:Predicted xylanase/chitin deacetylase:1-deoxy-D-xylulose 5-phosphate reductoisomerase:Predicted membrane-associated Zn-dependent proteases 1:RimM protein, required for 16S rRNA processing:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Actin-like ATPase involved in cell morphogenesis:Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase):Cell shape-determining protein:Uncharacterized protein conserved in bacteria:Tetrahydrodipicolinate N-succinyltransferase:Cell shape-determining protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Galactose metabolism:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Lysine biosynthesis:Glycerophospholipid metabolism:Pyruvate metabolism:Methane metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00054:tig:tsf:mreC:Dxr:proS_fam_II:mreB:pyruv_kin:16S_RimM:PFKA_ATP:spore_ylxY:shape_MreD:DapD_Ac:polynuc_phos:Other:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Folding Sorting and Degradation:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Transcription:Degradation of RNA:RNA processing:Protein synthesis:tRNA aminoacylation:Translation factors:Protein fate:Protein folding and stabilization:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Sporulation and germination:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 254 "Predicted hydrolases of the HAD superfamily:FOG: CheY-like receiver:Hydrolases of the alpha/beta superfamily:Flagellar biosynthesis/type III secretory pathway ATPase:Flagellar biosynthesis/type III secretory pathway protein:Flagellar biosynthesis pathway, component FliP:Flagellar motor switch protein:Flagellar basal body rod protein:Flagellar basal body-associated protein:Flagellar hook-basal body protein:Flagellar biosynthesis/type III secretory pathway lipoprotein:Flagellar basal body protein:Flagellar hook capping protein:Flagellar motor switch protein:Putative cell wall-binding domain:Sporulation protein and related proteins:Flagellar biosynthesis chaperone:Flagellar hook-length control protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Flagellar basal body rod protein:Cell cycle control, cell division, chromosome partitioning:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:Cof-subfamily:fliE:fliF:fliG:fliI_yscN:fliP:FlgC:FlgB:fliM_switch:flagell_FliJ:fliN:flgF:SpoIID_LytB:FliH_bacil:Intracellular trafficking, secretion, and vesicular transport:Cellular processes:ATP-proton motive force interconversion:Energy metabolism:Chemotaxis and motility:Unknown function:Enzymes of unknown specificity:General:Cellular processes and signaling:Poorly characterized:Environmental Information Processing:Cell Motility:Cellular Processes:Signal Transduction" 255 "Glutamate-1-semialdehyde aminotransferase:Thymidylate synthase:Leucyl aminopeptidase:Predicted hydrolases of the HAD superfamily:Enoyl-[acyl-carrier-protein] reductase (NADH):Predicted sugar phosphatases of the HAD superfamily:Phosphopantetheinyl transferase (holo-ACP synthase):dUTPase:Amino acid transporters:Adenine deaminase:Putative threonine efflux protein:Transcriptional regulator:Amidases related to nicotinamidase:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:Transcriptional regulators:Type II secretory pathway, pullulanase PulA and related glycosidases:Predicted periplasmic solute-binding protein:Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase:Transcriptional regulators:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Uncharacterized conserved protein:Predicted permeases:Predicted signal transduction protein containing EAL and modified HD-GYP domains:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Glutathione metabolism:One carbon pool by folate:Pantothenate and CoA biosynthesis:Porphyrin and chlorophyll metabolism:Biosynthesis of siderophore group nonribosomal peptides:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:Cof-subfamily:TIGR00147:TIGR00247:acpS:rarD:hemL:2A76:ade:HAD-SF-IIA-hyp2:pulA_typeI:thym_sym:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Nucleotide Metabolism:Unknown function:Lipid Metabolism:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Conserved:Hypothetical proteins:Amino acids, peptides and amines:Unknown substrate:Transport and binding proteins:2'-Deoxyribonucleotide metabolism:Salvage of nucleosides and nucleotides:Purines, pyrimidines, nucleosides, and nucleotides" 256 "Energy production and conversion:Xaa-Pro aminopeptidase:Malate/lactate dehydrogenases:Succinyl-CoA synthetase, beta subunit:Succinyl-CoA synthetase, alpha subunit:Nucleoside diphosphate kinase:Fe-S oxidoreductase:Phosphotransacetylase:Glutamate dehydrogenase/leucine dehydrogenase:Citrate synthase:Peroxiredoxin:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:Isocitrate dehydrogenases:2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes:Predicted dehydrogenases and related proteins:Alanine dehydrogenase:ABC-type transport system involved in cytochrome c biogenesis, permease component:3-dehydroquinate dehydratase II:Cell wall-associated hydrolases (invasion-associated proteins):Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Uncharacterized conserved protein containing a ferredoxin-like domain:ResB protein required for cytochrome c biosynthesis:2'-5' RNA ligase:Uncharacterized conserved protein:Phosphoserine aminotransferase:Succinate dehydrogenase/fumarate reductase, cytochrome b subunit:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Lysine degradation:Arginine and proline metabolism:Tryptophan metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Taurine and hypotaurine metabolism:Glutathione metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Vitamin B6 metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:prok_nadp_idh:2oxo_dh_E1:TIGR00273:alaDH:pta:sucCoAbeta:sucCoAalpha:aroQ:sucB:serC_1:MalateDH_bact:cit_synth_II:sdhA_Bsu:sdhC_b558_fam:2_5_ligase:cytochr_II_ccsB:Nucleotide Metabolism:Metabolism:Energy Metabolism:TCA cycle:Carbohydrate Metabolism:Transcription:RNA processing:Protein fate:Protein modification and repair:Amino acid biosynthesis:Aromatic amino acid family:Serine family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Fermentation:Electron transport:Amino acids and amines:Energy metabolism:Metabolism:Global:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism" 257 "Dihydroorotase and related cyclic amidohydrolases:Acetyltransferase (isoleucine patch superfamily):Lactoylglutathione lyase and related lyases:ADP-ribose pyrophosphatase:ABC-type multidrug transport system, ATPase and permease components:Transcriptional regulators:Cytochrome P450:Regulator of polyketide synthase expression:V8-like Glu-specific endopeptidase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Transcription:Purine metabolism:Bisphenol degradation:Pyruvate metabolism:Polycyclic aromatic hydrocarbon degradation:Aminobenzoate degradation:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:allantoinase:Defense mechanisms:Cellular processes and signaling:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Global:Metabolism:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 258 "Energy production and conversion:Integral membrane protein possibly involved in chromosome condensation:L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D:Diaminopimelate epimerase:ATPase components of ABC transporters with duplicated ATPase domains:Glycerophosphoryl diester phosphodiesterase:Rhodanese-related sulfurtransferase:Predicted transcriptional regulators:Signal transduction histidine kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Predicted transcriptional regulators:Predicted hydrolase (HAD superfamily):Aspartate ammonia-lyase:Gamma-aminobutyrate permease and related permeases:Transcriptional regulator:Predicted transcriptional regulators:Predicted phosphohydrolases:Predicted transcriptional regulators:Predicted transcriptional regulators:Transcriptional regulators:Periplasmic molybdate-binding protein/domain:Glutaminase:Uncharacterized protein conserved in bacteria:Regulator of polyketide synthase expression:Dipeptide/tripeptide permease:Uncharacterized conserved protein:Predicted integral membrane protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Lysine biosynthesis:Arginine and proline metabolism:Cyanoamino acid metabolism:D-Glutamine and D-glutamate metabolism:Glycerophospholipid metabolism:Chloroalkane and chloroalkene degradation:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:asnASE_I:DapF:aspA:yjdL_sub1_fam:HAD-SF-IA-v1:excise:Gln_ase:Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Xenobiotics Biodegradation and Metabolism:Global:Metabolism:Energy metabolism:Amino acids and amines:Transport and binding proteins:Amino acids, peptides and amines:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 259 "Energy production and conversion:Uncharacterized conserved protein:Predicted GTPase:Thioredoxin reductase:Thiol-disulfide isomerase and thioredoxins:Glycerophosphoryl diester phosphodiesterase:Aldo/keto reductases, related to diketogulonate reductase:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Putative intracellular protease/amidase:NAD-dependent aldehyde dehydrogenases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Hemolysins and related proteins containing CBS domains:NADH:flavin oxidoreductases, Old Yellow Enzyme family:Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family:3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:Putative NADPH-quinone reductase (modulator of drug activity B):Uncharacterized protein conserved in bacteria:Predicted Zn-dependent protease:Penicillin V acylase and related amidases:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Fructose and mannose metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine degradation:Tyrosine metabolism:Bisphenol degradation:Glycerophospholipid metabolism:Chloroalkane and chloroalkene degradation:Butanoate metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:small_GTP:TIGR01033:thioredoxin:TRX_reduct:PfpI:SSADH:oxido_grp_1:Poorly characterized:Metabolism:Cellular processes and signaling:General:Enzymes of unknown specificity:Unknown function:Degradation of proteins, peptides, and glycopeptides:Protein fate:DNA interactions:Regulatory functions:Electron transport:Energy metabolism:Other:Central intermediary metabolism:Metabolism:Metabolism:Global:Xenobiotics Biodegradation and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism" 260 "Site-specific recombinase XerC:Replication, recombination and repair:Information storage and processing" 261 "EMAP domain:Molybdopterin biosynthesis enzyme:Molybdopterin converting factor, large subunit:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:Na+/proline symporter:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type proline/glycine betaine transport systems, ATPase components:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type proline/glycine betaine transport systems, permease component:Predicted transcriptional regulators:Predicted metal-dependent hydrolase with the TIM-barrel fold:Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein):Molybdopterin-guanine dinucleotide biosynthesis protein:AraC-type DNA-binding domain-containing proteins:Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides:Acetyl esterase (deacetylase):Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:ABC-type oligopeptide transport system, periplasmic component:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Penicillin and cephalosporin biosynthesis:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:mobB:molyb_syn:sensory_box:sss:proV:oligo_HPY:chap_CsaA:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Molybdopterin:Biosynthesis of cofactors, prosthetic groups, and carriers:Cations and iron carrying compounds:Amino acids, peptides and amines:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Small molecule interactions:Regulatory functions:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Energy Metabolism:Carbohydrate Metabolism" 262 "Energy production and conversion:Site-specific DNA methylase:Nuclease subunit of the excinuclease complex:Thiamine monophosphate synthase:Uncharacterized conserved protein:Signal peptidase I:Nitroreductase:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulator:Uncharacterized low-complexity proteins:Uncharacterized protein conserved in bacteria:Predicted phosphohydrolases:Transcriptional regulators:GAF domain-containing protein:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:Hydroxyethylthiazole kinase, sugar kinase family:Uncharacterized domain/protein associated with RNAses G and E:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cysteine and methionine metabolism:Thiamine metabolism:Metabolic pathways:Protein export:Nucleotide excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:uvrC:dcm:thiE:thiM:sigpep_I_bact:oxido_grp_1:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function:Protein and peptide secretion and trafficking:Protein fate:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Metabolism:Global:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Poorly characterized:Amino Acid Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Thiamine" 263 "Predicted 6-phosphogluconate dehydrogenase:Predicted membrane protein/domain:Putative NADH-flavin reductase:Uncharacterized conserved protein:Carbohydrate transport and metabolism:Pentose phosphate pathway:Glutathione metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA polymerase:General function prediction only:Function unknown:gnd_rel:spore_YhcN_YlaJ:Energy metabolism:Pentose phosphate pathway:Cellular processes:Sporulation and germination:Metabolism:Poorly characterized:Metabolism:Metabolism:Global:Transcription:Genetic Information Processing:Metabolism of Other Amino Acids:Carbohydrate Metabolism" 264 "Energy production and conversion:Exoribonuclease R:Transcriptional regulator:Aconitase A:Uncharacterized conserved protein:Uncharacterized conserved protein:Transcription:Citrate cycle (TCA cycle):Glyoxylate and dicarboxylate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:Function unknown:3_prime_RNase:aconitase_1:TCA cycle:Transcription:Degradation of RNA:Information storage and processing:Metabolism:Poorly characterized:Energy metabolism:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Genetic Information Processing:Energy Metabolism:Carbohydrate Metabolism" 265 "Predicted N6-adenine-specific DNA methylase:Protein chain release factor A:Thiamine biosynthesis ATP pyrophosphatase:Lactoylglutathione lyase and related lyases:UDP-N-acetylmuramate-alanine ligase:Predicted UDP-glucose 6-dehydrogenase:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Phosphomannomutase:ABC-type polysaccharide/polyol phosphate transport system, ATPase component:Predicted Fe-S oxidoreductase:Uncharacterized conserved protein:Mg/Co/Ni transporter MgtE (contains CBS domain):Arabinose efflux permease:Methylase of polypeptide chain release factors:Penicillin-binding protein-related factor A, putative recombinase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:D-Glutamine and D-glutamate metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Thiamine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Sulfur relay system:General function prediction only:Function unknown:prfA:TIGR00159:TIGR00342:mgtE:hemK_fam:recU:2A0121:murC:TIGR01212:glmM:NDP-sugDHase:T7_EssCb_Firm:Cell envelope:Carbohydrate Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Amino sugars:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Transport and binding proteins:Cations and iron carrying compounds:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 266 "Energy production and conversion:Predicted GTPase, probable translation factor:GTP cyclohydrolase I:Nucleotide-binding protein implicated in inhibition of septum formation:Superfamily II DNA and RNA helicases:Aspartokinases:Penicillin tolerance protein:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain:NADH dehydrogenase, FAD-containing subunit:Cold shock proteins:Uncharacterized conserved protein:Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC:DNA repair proteins:HD-GYP domain:Growth inhibitor:Uncharacterized conserved protein:Septum formation inhibitor-activating ATPase:SH3 domain protein:DNA-directed RNA polymerase, delta subunit:Predicted secreted protein:ABC-type enterochelin transport system, ATPase component:ABC-type enterochelin transport system, permease component:ABC-type enterochelin transport system, permease component:ABC-type enterochelin transport system, periplasmic component:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Folate biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Ribosome:RNA polymerase:Function unknown:Signal transduction mechanisms:S21p:folE:TIGR00092:maf:ispH_lytB:HDIG:radc:asp_kin_monofn:rpmH_bact:HEQRo_perm_3TM:minD_bact:Metabolism:Cellular processes and signaling:Information storage and processing:Folic acid:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Aspartate family:Amino acid biosynthesis:General:Unknown function:Cell division:Cellular processes:Amino acids, peptides and amines:Transport and binding proteins:Ribosomal proteins: synthesis and modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Translation:Transcription:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Poorly characterized:Energy Metabolism" 267 "Energy production and conversion:Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Dihydroorotase and related cyclic amidohydrolases:Adenylosuccinate synthase:Dihydroorotate dehydrogenase:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:Pyridoxine biosynthesis enzyme:Orotidine-5'-phosphate decarboxylase:Predicted glutamine amidotransferase involved in pyridoxine biosynthesis:Carbamoylphosphate synthase large subunit (split gene in MJ):Orotate phosphoribosyltransferase:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Carbamoylphosphate synthase small subunit:Aspartate carbamoyltransferase, catalytic chain:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:Transcription termination factor:Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase:Xanthine/uracil permeases:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Transcription:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:One carbon pool by folate:Carbon fixation pathways in prokaryotes:Vitamin B6 metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:purA:pyrE:TIGR00343:asp_carb_tr:ncs2:pyrC_multi:pyrD_sub1_fam:purE:CPSaseIIsmall:CPSaseII_lrg:pyrF:XPRTase:nusB:PLP_synth_Pdx2:Global:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Purine ribonucleotide biosynthesis:Energy Metabolism:Pyrimidine ribonucleotide biosynthesis:Salvage of nucleosides and nucleotides:Transcription:Transcription factors:Transport and binding proteins:Nucleosides, purines and pyrimidines:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridoxine:Information storage and processing:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism" 268 "Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Putative Ser protein kinase:Mn-containing catalase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Inorganic ion transport and metabolism:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:HEQRo_perm_3TM:spore_gerQ:spore_IV_A:spore_III_D:spore_ysxE:Poorly characterized:Membrane Transport:Transport and binding proteins:Amino acids, peptides and amines:Cellular processes:Sporulation and germination:Cellular processes and signaling:Metabolism:Environmental Information Processing" 269 "Uncharacterized protein containing LysM domain:Phage terminase large subunit:Uncharacterized homolog of phage Mu protein gp47:Phage terminase, small subunit:Phage-related protein:Bacteriophage capsid portal protein:N-acetylmuramoyl-L-alanine amidase:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:General function prediction only:Function unknown:portal_PBSX:phage_term_2:phage_XkdX:Cellular processes and signaling:Information storage and processing:Prophage functions:Mobile and extrachromosomal element functions:Poorly characterized" 270 "Thymidylate synthase:Dihydrofolate reductase:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Amino acid transporters:Transcriptional regulator:Signal transduction histidine kinase:Predicted permeases:Glutamate racemase:Transcriptional regulator:Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains:Phage terminase large subunit:Transcriptional regulators:Predicted acyltransferases:Transcriptional regulators:Predicted acyltransferase:Uncharacterized conserved protein:Predicted membrane protein:Transcriptional regulator:Arabinose efflux permease:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Pyrimidine metabolism:D-Glutamine and D-glutamate metabolism:One carbon pool by folate:Folate biosynthesis:Metabolic pathways:General function prediction only:Function unknown:Signal transduction mechanisms:glut_race:TIGR00244:phage_term_2:thym_sym:Metabolism:Global:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Poorly characterized:Nucleotide Metabolism:Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope:Prophage functions:Mobile and extrachromosomal element functions:DNA interactions:Regulatory functions:2'-Deoxyribonucleotide metabolism:Purines, pyrimidines, nucleosides, and nucleotides" 271 "Predicted N6-adenine-specific DNA methylase:Trk-type K+ transport systems, membrane components:Replicative DNA helicase:Superfamily II DNA/RNA helicases, SNF2 family:Uncharacterized membrane protein, putative virulence factor:ABC-type Mn2+/Zn2+ transport systems, permease components:ABC-type Mn/Zn transport systems, ATPase component:Rad3-related DNA helicases:Transglutaminase-like enzymes, putative cysteine proteases:Transcriptional regulator:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:ABC transporters:DNA replication:General function prediction only:Signal transduction mechanisms:TIGR00147:DnaB:efflux_EmrB:DNA replication, recombination, and repair:DNA metabolism:Membrane Transport:Environmental Information Processing:Information storage and processing:Replication and Repair:Cellular processes and signaling:Metabolism:Poorly characterized:Genetic Information Processing:Enzymes of unknown specificity:Unknown function:Other:Transport and binding proteins" 272 "tRNA and rRNA cytosine-C5-methylases:Guanylate kinase:Methionyl-tRNA formyltransferase:N-formylmethionyl-tRNA deformylase:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Queuine/archaeosine tRNA-ribosyltransferase:Dihydroxynaphthoic acid synthase:Phosphopantothenoylcysteine synthetase/decarboxylase:NTP pyrophosphohydrolases including oxidative damage repair enzymes:ATPase involved in DNA repair:Aspartokinases:S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase):Predicted Fe-S-cluster redox enzyme:Isochorismate synthase:Primosomal protein N' (replication factor Y) - superfamily II helicase:ATP-dependent protease HslVU (ClpYQ), ATPase subunit:Arginine repressor:DNA-directed RNA polymerase, subunit K/omega:Uncharacterized protein conserved in bacteria:Nitric oxide reductase activation protein:ATP-dependent protease HslVU (ClpYQ), peptidase subunit:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:One carbon pool by folate:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Biosynthesis of siderophore group nonribosomal peptides:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA polymerase:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00048:pept_deformyl:queA:hslU:Q_tRNA_tgt:fmt:coaBC_dfp:isochor_syn:rsmB:priA:recN:asp_kin_monofn:dapA:rpoZ:argR_whole:menB:guanyl_kin:ATP_dep_HslV:Menaquinone and ubiquinone:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Transcription:Translation:Replication and Repair:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Regulatory functions:DNA interactions:DNA metabolism:DNA replication, recombination, and repair:Transcription:DNA-dependent RNA polymerase:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein folding and stabilization:Degradation of proteins, peptides, and glycopeptides:Protein modification and repair:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 273 "Transketolase:Pseudouridine synthase:Acyl carrier protein:(acyl-carrier-protein) S-malonyltransferase:Preprotein translocase subunit SecD:Dihydroxynaphthoic acid synthase:Pyruvate kinase:Biotin carboxyl carrier protein:FOG: CBS domain:Predicted integral membrane protein:Phosphopentomutase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ATP-dependent protease HslVU (ClpYQ), ATPase subunit:Uncharacterized protein conserved in bacteria:Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins:Uncharacterized protein conserved in bacteria:Regulators of stationary/sporulation gene expression:Di- and tripeptidases:Uncharacterized conserved protein (small basic protein):Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein):Acetyl/propionyl-CoA carboxylase, alpha subunit:ATP-dependent protease HslVU (ClpYQ), peptidase subunit:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Fatty acid biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Pyruvate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:fabD:tktlase_bact:glpX:hslU:TruB:accC:acyl_carrier:BCCP:2A0604s01:pyruv_kin:lp_hng_hel_AbrB:deoB:3oxo_ACP_reduc:PepT-like:menB:ATP_dep_HslV:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Pentose phosphate pathway:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Other:Regulatory functions:DNA interactions:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein folding and stabilization:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 274 "Uncharacterized conserved protein:DNA repair photolyase:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:FOG: EAL domain:Beta-lactamase class A:Uncharacterized protein conserved in bacteria:Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta):Uncharacterized protein conserved in bacteria:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Valine leucine and isoleucine degradation:Penicillin and cephalosporin biosynthesis:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:RNA polymerase:Function unknown:Signal transduction mechanisms:sigma70-ECF:photo_TT_lyase:Defense mechanisms:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Transcription:Environmental Information Processing:Signal Transduction:Global:Metabolism:Cellular processes:Sporulation and germination:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 275 "Acetylglutamate semialdehyde dehydrogenase:Ornithine carbamoyltransferase:Argininosuccinate synthase:Argininosuccinate lyase:Carbamoylphosphate synthase large subunit (split gene in MJ):Carbamoylphosphate synthase small subunit:Acetylglutamate kinase:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type polar amino acid transport system, ATPase component:N-acetylglutamate synthase (N-acetylornithine aminotransferase):Ornithine/acetylornithine aminotransferase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Lysine biosynthesis:Arginine and proline metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Signal transduction mechanisms:argG:ArgJ:orni_carb_tr:argD:argB:argH:CPSaseIIsmall:CPSaseII_lrg:HEQRo_perm_3TM:argC:Metabolism:Cellular processes and signaling:Glutamate family:Amino acid biosynthesis:Amino acids, peptides and amines:Transport and binding proteins:Pyrimidine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Amino Acid Metabolism:Nucleotide Metabolism" 276 "Acetyltransferase (isoleucine patch superfamily):Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Glycosyltransferase:Glycosyltransferases involved in cell wall biogenesis:ATPases involved in chromosome partitioning:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Predicted nucleoside-diphosphate sugar epimerases:Predicted glycosyltransferases:Subtilisin-like serine proteases:FOG: WD40-like repeat:Uncharacterized protein conserved in bacteria:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Uncharacterized protein involved in propionate catabolism:Sugar transferases involved in lipopolysaccharide synthesis:Predicted aminoglycoside phosphotransferase:Ethanolamine utilization protein:Predicted naringenin-chalcone synthase:Capsular polysaccharide biosynthesis protein:Exopolysaccharide biosynthesis protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Metabolic pathways:Biosynthesis of secondary metabolites:Protein export:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:unchar_dom_1:eps_fam:sigpep_I_arch:NeuD_NnaD:YqxM_for_SipW:cognate_SipW:Folding Sorting and Degradation:Genetic Information Processing:Poorly characterized:Metabolism:Cellular processes and signaling:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Metabolism:Global" 277 "Energy production and conversion:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit:Nucleoside-diphosphate-sugar epimerases:Glycosyltransferases involved in cell wall biogenesis:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:Membrane proteins related to metalloendopeptidases:Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Peroxiredoxin:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Uncharacterized conserved protein:Membrane protein involved in the export of O-antigen and teichoic acid:Transcriptional activator of acetoin/glycerol metabolism:Uncharacterized conserved protein:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Pyruvate metabolism:Butanoate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:lipoamide_DH:TIGR04086_membr:Metabolism:Metabolism:Poorly characterized:Amino Acid Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Global:Carbohydrate Metabolism" 278 "Energy production and conversion:Citrate synthase:Glycosyltransferases involved in cell wall biogenesis:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Amino acid permeases:N-acetylglutamate synthase and related acetyltransferases:Acyl-CoA dehydrogenases:Predicted membrane protein:PEP phosphonomutase and related enzymes:H+/citrate symporter:Predicted integral membrane protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Citrate cycle (TCA cycle):Geraniol degradation:Naphthalene degradation:Glyoxylate and dicarboxylate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:citMHS:2A0309:intg_mem_TP0381:prpB:spore_II_R:spore_ger_x_C:Global:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Amino acids, peptides and amines:Carbohydrate Metabolism:Carbohydrates, organic alcohols, and acids:Cellular processes:Sporulation and germination:Cellular processes and signaling:Metabolism:Poorly characterized:Transport and binding proteins:Metabolism:Metabolism" 279 "Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Putative phage replication protein RstA:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Information storage and processing:Cellular processes and signaling" 280 "Glycosidases:Uncharacterized protein conserved in bacteria:Cytochrome P450:Methylase involved in ubiquinone/menaquinone biosynthesis:Uncharacterized protein conserved in bacteria:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Galactose metabolism:Starch and sucrose metabolism:Metabolic pathways:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:spore_yabG:spore_yqfC:spore_ylbJ:spore_yqfD:Sporulation and germination:Carbohydrate Metabolism:Global:Metabolism:Cellular processes:Metabolism:Metabolism:Poorly characterized" 281 "Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Glycosyltransferase:Nucleoside-diphosphate-sugar epimerases:Glycosyltransferases involved in cell wall biogenesis:Na+/H+ antiporter NhaD and related arsenite permeases:dTDP-D-glucose 4,6-dehydratase:dTDP-4-dehydrorhamnose reductase:dTDP-glucose pyrophosphorylase:Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog:Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:Putative homoserine kinase type II (protein kinase fold):Patatin:Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:dTDP_gluc_dehyt:rmlD:spore_yabG:spore_CotS:Poorly characterized:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Global:Metabolism:Cellular processes:Sporulation and germination:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Metabolism" 282 "Energy production and conversion:FAD/FMN-containing dehydrogenases:Glycosyltransferases involved in cell wall biogenesis:FOG: CBS domain:Threonine dehydrogenase and related Zn-dependent dehydrogenases:Cytochrome bd-type quinol oxidase, subunit 1:Cytochrome bd-type quinol oxidase, subunit 2:Predicted membrane protein:Uncharacterized conserved protein:Spore coat protein:Amino acid transport and metabolism:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Fatty acid metabolism:Oxidative phosphorylation:Purine metabolism:Tyrosine metabolism:Chloroalkane and chloroalkene degradation:Naphthalene degradation:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:SASP_tlp:SASP_sspI:export_SdpA:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Xenobiotics Biodegradation and Metabolism:Global:Metabolism:Cellular processes:Sporulation and germination:Cellular processes and signaling:Metabolism:Poorly characterized" 283 "Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains:N-acetylmuramoyl-L-alanine amidase:Transcriptional antiterminator:Transcription:Cell wall/membrane/envelope biogenesis:Alanine aspartate and glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:glmS:Central intermediary metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Global:Metabolism:Metabolism:Amino sugars:Information storage and processing:Cellular processes and signaling" 284 "6-phosphogluconate dehydrogenase:DNA repair exonuclease:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:Regulators of stationary/sporulation gene expression:Uncharacterized protein involved in propionate catabolism:H+/gluconate symporter and related permeases:Predicted membrane protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Pentose phosphate pathway:Glutathione metabolism:Propanoate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:TIGR00093:gntP:gnd:lp_hng_hel_AbrB:prpD:Metabolism:Poorly characterized:Pentose phosphate pathway:Energy metabolism:Metabolism:Metabolism:Global:Metabolism of Other Amino Acids:Regulatory functions:Carbohydrate Metabolism:DNA interactions:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Information storage and processing" 285 "Energy production and conversion:Acetyltransferase (isoleucine patch superfamily):Tyrosyl-tRNA synthetase:Deoxyribose-phosphate aldolase:Glycerophosphoryl diester phosphodiesterase:2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases:Multimeric flavodoxin WrbA:N-acetylmuramoyl-L-alanine amidase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type multidrug transport system, ATPase and permease components:Dipeptidyl aminopeptidases/acylaminoacyl-peptidases:Glycosyl transferases, related to UDP-glucuronosyltransferase:Sugar phosphate permease:Peptidase E:Sugar diacid utilization regulator:Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation:Phage-related replication protein:Predicted membrane protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Pentose phosphate pathway:Glycerophospholipid metabolism:Aminoacyl-tRNA biosynthesis:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:deoC:tyrS:glpT:MGT:GPR:Defense mechanisms:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Sporulation and germination:Toxin production and resistance:Cellular processes:Other:Transport and binding proteins:tRNA aminoacylation:Protein synthesis:Other:Energy metabolism:Translation:Genetic Information Processing:Lipid Metabolism:Carbohydrate Metabolism" 286 "Cation transport ATPase:Uncharacterized membrane protein:Membrane proteins related to metalloendopeptidases:Peroxiredoxin:Uncharacterized conserved protein:Uncharacterized membrane protein:Zn-dependent proteases:Membrane protein involved in the export of O-antigen and teichoic acid:Uncharacterized membrane protein, required for spore maturation in B.subtilis.:Uncharacterized protein conserved in bacteria:Uncharacterized membrane protein:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:General function prediction only:Function unknown:ATPase-IIA1_Ca:spore_III_AE:spo_II_M:spore_III_AD:spore_III_AA:spore_III_AF:TIGR04086_membr:Cellular processes:Metabolism:Cellular processes and signaling:Sporulation and germination:Poorly characterized:Cations and iron carrying compounds:Transport and binding proteins" 287 "Na+-driven multidrug efflux pump:Adenylate kinase and related kinases:Predicted thioesterase:Threonine dehydrogenase and related Zn-dependent dehydrogenases:Sortase and related acyltransferases:Subtilisin-like serine proteases:Acetyltransferases, including N-acetylases of ribosomal proteins:Galactose mutarotase and related enzymes:D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4):Predicted aminopeptidases:Beta-lactamase class D:Ketosteroid isomerase homolog:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Penicillin and cephalosporin biosynthesis:Peptidoglycan biosynthesis:Chloroalkane and chloroalkene degradation:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:PBP4:matE:fdhA_non_GSH:Defense mechanisms:Information storage and processing:Energy Metabolism:Glycan Biosynthesis and Metabolism:Biosynthesis of Other Secondary Metabolites:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Signal Transduction:Global:Metabolism:Central intermediary metabolism:One-carbon metabolism:Transport and binding proteins:Other:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 288 "tRNA and rRNA cytosine-C5-methylases:Guanylate kinase:Methionyl-tRNA formyltransferase:N-formylmethionyl-tRNA deformylase:Predicted methyltransferases:Phosphopantothenoylcysteine synthetase/decarboxylase:ATPase involved in DNA repair:Predicted Fe-S-cluster redox enzyme:Deoxyxylulose-5-phosphate synthase:Predicted rRNA methylase:Primosomal protein N' (replication factor Y) - superfamily II helicase:Arginine repressor:Uncharacterized stress-induced protein:DNA-directed RNA polymerase, subunit K/omega:Uncharacterized protein conserved in bacteria:Predicted endonuclease containing a URI domain:Predicted O-methyltransferase:Nitric oxide reductase activation protein:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:One carbon pool by folate:Pantothenate and CoA biosynthesis:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:RNA polymerase:Homologous recombination:General function prediction only:Function unknown:TIGR00048:pept_deformyl:TIGR00096:dxs:TIGR00255:fmt:tly:coaBC_dfp:rsmB:priA:recN:rpoZ:argR_whole:guanyl_kin:Biosynthesis of cofactors, prosthetic groups, and carriers:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Transcription:Translation:Replication and Repair:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Regulatory functions:DNA interactions:DNA metabolism:DNA replication, recombination, and repair:Transcription:DNA-dependent RNA polymerase:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein modification and repair:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:General:Metabolism:Pantothenate and coenzyme A:Thiamine:Information storage and processing:Metabolism:Poorly characterized" 289 "Pentose-5-phosphate-3-epimerase:Geranylgeranyl pyrophosphate synthase:Prolyl-tRNA synthetase:Biotin carboxyl carrier protein:Serine/threonine protein kinase:Predicted Fe-S oxidoreductases:Predicted hydrolase of the metallo-beta-lactamase superfamily:Predicted Zn-dependent peptidases:Serine/threonine protein phosphatase:Predicted xylanase/chitin deacetylase:1-deoxy-D-xylulose 5-phosphate reductoisomerase:Predicted membrane-associated Zn-dependent proteases 1:Purine-nucleoside phosphorylase:Predicted GTPases:Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase):Uncharacterized protein conserved in bacteria:Predicted kinase related to dihydroxyacetone kinase:Methylase involved in ubiquinone/menaquinone biosynthesis:Uncharacterized conserved protein, contains S4-like domain:Acetyl/propionyl-CoA carboxylase, alpha subunit:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Pentose phosphate pathway:Pentose and glucuronate interconversions:Fatty acid biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Pyrimidine metabolism:Pyruvate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Nicotinate and nicotinamide metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00054:deoD:TIGR00157:Dxr:proS_fam_II:accC:BCCP:MG423:rpe:MenG_MenH_UbiE:GerC3_HepT:spore_ylxY:polynuc_phos:YloV:Other:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Folding Sorting and Degradation:Global:Metabolism:Energy metabolism:Pentose phosphate pathway:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:Transcription:Degradation of RNA:Protein synthesis:tRNA aminoacylation:Translation factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Sporulation and germination:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Menaquinone and ubiquinone:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 290 "Uncharacterized conserved protein:Uncharacterized membrane protein, possible Na+ channel or pump:Sugar phosphate permease:Carbohydrate transport and metabolism:General function prediction only:Function unknown:2A0309:spore_ger_x_C:Metabolism:Sporulation and germination:Poorly characterized:Amino acids, peptides and amines:Transport and binding proteins:Cellular processes" 291 "Uncharacterized conserved protein:Glycosyltransferases involved in cell wall biogenesis:Putative GTPases (G3E family):Transcriptional regulator:Predicted transcriptional regulators:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Uncharacterized conserved protein:Putative threonine efflux protein:Putative effector of murein hydrolase:Uncharacterized protein conserved in bacteria:Sulfite oxidase and related enzymes:Arabinose efflux permease:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:N-acetylmuramoyl-L-alanine amidase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Starch and sucrose metabolism:Metabolic pathways:Phosphotransferase system (PTS):General function prediction only:Function unknown:TIGR00659:sortase_fam:PTS-II-BC-sucr:Protein fate:Metabolism:Global:Membrane Transport:Environmental Information Processing:Poorly characterized:Carbohydrate Metabolism:Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Conserved:Hypothetical proteins:Protein and peptide secretion and trafficking" 292 "Purine nucleoside phosphorylase:Uracil phosphoribosyltransferase:Ribosomal protein L9:Phosphoribosylpyrophosphate synthetase:NTP pyrophosphohydrolases including oxidative damage repair enzymes:Topoisomerase IA:Thioredoxin-like proteins and domains:Membrane carboxypeptidase (penicillin-binding protein):Glutamate racemase:Ribosome-binding factor A:Predicted GTPases:N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains):Mn-dependent transcriptional regulator:Uncharacterized conserved protein:DNA replication protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Transcriptional regulators:Uncharacterized protein involved in propionate catabolism:DNA polymerase III, gamma/tau subunits:Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Pentose phosphate pathway:Purine metabolism:Pyrimidine metabolism:D-Glutamine and D-glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Propanoate metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Ribosome:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:glut_race:rbfA:L9:TIGR00375:topA_bact:upp:glmU:ribP_PPkin:PNPH-PUNA-XAPA:PBP_1a_fam:prpD:dnaX_nterm:GTPase_YlqF:Biosynthesis and degradation of murein sacculus and peptidoglycan:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:Central intermediary metabolism:Amino sugars:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Salvage of nucleosides and nucleotides:DNA metabolism:DNA replication, recombination, and repair:Transcription:RNA processing:Protein synthesis:Other:Ribosomal proteins: synthesis and modification:Hypothetical proteins:Conserved:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 293 "Energy production and conversion:Predicted EndoIII-related endonuclease:L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D:Guanosine polyphosphate pyrophosphohydrolases/synthetases:Predicted xylanase/chitin deacetylase:Membrane carboxypeptidase (penicillin-binding protein):Acetyl-CoA carboxylase beta subunit:Acetyl-CoA carboxylase alpha subunit:NAD-dependent aldehyde dehydrogenases:Aspartate ammonia-lyase:Uncharacterized conserved protein:Alcohol dehydrogenase, class IV:Predicted transcriptional regulators:Transcriptional regulators:Transcriptional regulators:Predicted phosphate-binding enzymes, TIM-barrel fold:Integral membrane protein CcmA involved in cell shape determination:Na+/H+ antiporter:Membrane transporters of cations and cationic drugs:Transcriptional regulators:Arabinose efflux permease:Uncharacterized protein conserved in bacteria:Replication initiation/membrane attachment protein:Putative primosome component and related proteins:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Purine metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cyanoamino acid metabolism:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Base excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:YbgI_SA1388:accA:accD:asnASE_I:spoT_relA:aspA:antiport_nhaC:nth:DnaD_dom:GGGP-family:BADH:PBP_1a_fam:spore_pdaA:Fatty acid and phospholipid metabolism:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Transport and binding proteins:Carbohydrate Metabolism:Cations and iron carrying compounds:Cellular processes:Adaptations to atypical conditions:Sporulation and germination:Mobile and extrachromosomal element functions:Prophage functions:Unknown function:General:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:DNA replication, recombination, and repair:DNA metabolism:Biosynthesis" 294 "Na+/proline symporter:Predicted permeases:Predicted transcriptional regulators:ABC-type metal ion transport system, periplasmic component/surface adhesin:Membrane protein TerC, possibly involved in tellurium resistance:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Membrane transporters of cations and cationic drugs:Permeases:Phenolic acid decarboxylase:Uncharacterized protein conserved in bacteria:UV damage repair endonuclease:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:uvde:sss:R_switched_YkoY:DNA metabolism:Environmental Information Processing:Membrane Transport:Poorly characterized:Metabolism:Information storage and processing:Cations and iron carrying compounds:Transport and binding proteins:DNA replication, recombination, and repair" 295 "Predicted flavoprotein:Kef-type K+ transport systems, membrane components:Gamma-aminobutyrate permease and related permeases:Na+/alanine symporter:Transcriptional regulator/sugar kinase:Site-specific recombinases, DNA invertase Pin homologs:Predicted membrane protein:Putative homoserine kinase type II (protein kinase fold):Endoglucanase:Barstar, RNAse (barnase) inhibitor:ABC-type Fe3+-citrate transport system, periplasmic component:O-Glycosyl hydrolase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Starch and sucrose metabolism:ABC transporters:Two-component system:General function prediction only:Function unknown:agcS:GABAperm:Membrane Transport:Environmental Information Processing:Poorly characterized:Carbohydrate Metabolism:Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Amino acids, peptides and amines:Transport and binding proteins:Signal Transduction" 296 "3-hexulose-6-phosphate synthase and related proteins:ATPases involved in chromosome partitioning:Universal stress protein UspA and related nucleotide-binding proteins:DNA-binding ferritin-like protein (oxidative damage protectant):Predicted sugar phosphate isomerase involved in capsule formation:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type multidrug transport system, ATPase and permease components:Cellulase M and related proteins:2'-5' RNA ligase:Ribosome-associated protein Y (PSrp-1):Predicted transcriptional regulators:Glycerate kinase:Multiple antibiotic transporter:Predicted acyltransferase:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Enterochelin esterase and related enzymes:Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain:Uncharacterized protein conserved in bacteria:Gas vesicle protein:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Fatty acid biosynthesis:Glycine serine and threonine metabolism:Glycerolipid metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00045:TIGR00427:yfiA:RuMP_HxlB:RuMP_HxlA:WXG100_ESAT6:B_thiol_YtxJ:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Unknown function:Translation factors:Protein synthesis:Other:Energy metabolism:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Global:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Enzymes of unknown specificity:Carbohydrate Metabolism" 297 "Thymidylate kinase:Site-specific DNA methylase:Uncharacterized phage-encoded protein:Nucleotide transport and metabolism:Replication, recombination and repair:Cysteine and methionine metabolism:Metabolic pathways:Function unknown:dcm:phage_XkdX:phage_pRha:Mobile and extrachromosomal element functions:Amino Acid Metabolism:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Metabolism:Prophage functions:Information storage and processing:Metabolism:Poorly characterized" 298 "Energy production and conversion:Thiol-disulfide isomerase and thioredoxins:Predicted transcriptional regulators:Disulfide bond formation protein DsbB:ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain:Transcription:Posttranslational modification, protein turnover, chaperones:ABC transporters:Defense mechanisms:Environmental Information Processing:Metabolism:Cellular processes and signaling:Information storage and processing:Membrane Transport" 299 "Energy production and conversion:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Glycosidases:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Putative intracellular protease/amidase:Catalase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Predicted redox protein, regulator of disulfide bond formation:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Tryptophan metabolism:Starch and sucrose metabolism:Pyruvate metabolism:Methane metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:PfpI:TIGR02271:organ_hyd_perox:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Global:Metabolism:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Detoxification:Cellular processes and signaling:Metabolism:Poorly characterized" 300 "Isoleucyl-tRNA synthetase:Histidyl-tRNA synthetase:Seryl-tRNA synthetase:Aspartyl-tRNA synthetase:Cysteinyl-tRNA synthetase:Threonyl-tRNA synthetase:Leucyl-tRNA synthetase:Aspartokinases:rRNA methylases:Glycyl-tRNA synthetase, beta subunit:Glycyl-tRNA synthetase, alpha subunit:Serine acetyltransferase:DnaK suppressor protein:Uncharacterized protein conserved in bacteria:Predicted RNA-binding protein containing a PIN domain:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Sulfur metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:rRNA_methyl_3:glyS:glyQ:ileS:leuS_bact:serS:thrS:cysS:hisS:aspS_bact:asp_kin_monofn:cysE:Cellular processes and signaling:Information storage and processing:Serine family:Aspartate family:Amino acid biosynthesis:tRNA and rRNA base modification:tRNA aminoacylation:Protein synthesis:Metabolism:Metabolism:Global:Translation:Genetic Information Processing:Amino Acid Metabolism:Poorly characterized:Energy Metabolism:Metabolism" 301 "Energy production and conversion:Thymidylate synthase:Pseudouridylate synthases, 23S RNA-specific:Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit:Signal transduction histidine kinase:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Exonuclease III:Alanine racemase:Gamma-aminobutyrate permease and related permeases:Predicted membrane protein:Transcriptional regulators:Predicted membrane protein:Transcriptional accessory protein:Uncharacterized protein conserved in bacteria:ABC-type molybdate transport system, permease component:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pyrimidine metabolism:D-Alanine metabolism:One carbon pool by folate:Metabolic pathways:ABC transporters:Base excision repair:Function unknown:Signal transduction mechanisms:rluA_subfam:exoDNase_III:alr:modB_ABC:spore_ger_x_C:xxxLxxG_by_4:thym_sym:Poorly characterized:Nucleotide Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Anions:Cellular processes:Sporulation and germination:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 302 "EMAP domain:(acyl-carrier-protein) S-malonyltransferase:ABC-type sugar transport system, permease component:Aspartate/tyrosine/aromatic aminotransferase:Biotin carboxylase:Sugar kinases, ribokinase family:ABC-type Fe3+-hydroxamate transport system, periplasmic component:Predicted permeases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type sugar transport systems, permease components:FOG: LysM repeat:ABC-type sugar transport system, periplasmic component:Transcriptional regulators:Predicted sugar phosphate isomerase:Transcriptional regulators:Predicted phosphosugar isomerases:Predicted aminoglycoside phosphotransferase:ABC-type sugar transport systems, ATPase components:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Amino sugar and nucleotide sugar metabolism:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:TIGR00274:chap_CsaA:spore_safA:Membrane Transport:Environmental Information Processing:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope:Sporulation and germination:Cellular processes:Protein and peptide secretion and trafficking:Protein fate" 303 "Replicative DNA helicase:Single-stranded DNA-specific exonuclease:dUTPase:Intein/homing endonuclease:Nucleotide transport and metabolism:Replication, recombination and repair:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:recJ:intein_Cterm:DNA metabolism:Nucleotide Metabolism:Global:Metabolism:Metabolism:DNA replication, recombination, and repair:Information storage and processing:Metabolism" 304 "1,4-alpha-glucan branching enzyme:Glycogen synthase:Pyrroline-5-carboxylate reductase:Predicted permease:Glycine/D-amino acid oxidases (deaminating):Predicted xylanase/chitin deacetylase:Membrane proteins related to metalloendopeptidases:Cell division protein FtsI/penicillin-binding protein 2:N-acetylmuramoyl-L-alanine amidase:Na+/alanine symporter:ABC-type multidrug transport system, ATPase and permease components:Uncharacterized conserved protein:Predicted ATPase related to phosphate starvation-inducible protein PhoH:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Sporulation protein and related proteins:Uncharacterized conserved protein:V8-like Glu-specific endopeptidase:Predicted glycosyl hydrolase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Starch and sucrose metabolism:Metabolic pathways:General function prediction only:Function unknown:Signal transduction mechanisms:agcS:branching_enzym:glgA:spoVD_pbp:SpoIID_LytB:spore_ybaN_pdaB:spore_YyaC:spore_ytvI:spore_yhbH:spore_cwlD:spore_YlmC_YmxH:Defense mechanisms:Unknown function:Sporulation and germination:Cellular processes:Biosynthesis and degradation of polysaccharides:Energy metabolism:Metabolism:Metabolism:Global:Carbohydrate Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:General" 305 "Energy production and conversion:2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases:5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases:Sec-independent protein secretion pathway component TatC:Na+/alanine symporter:NAD(P)H-nitrite reductase:Uncharacterized protein containing LysM domain:Sec-independent protein secretion pathway components:Glutaminase:Xanthine/uracil permeases:Predicted drug exporters of the RND superfamily:Arabinose efflux permease:Uncharacterized homolog of phage Mu protein gp47:Phosphodiesterase/alkaline phosphatase D:Phage-related minor tail protein:Predicted integral membrane protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:D-Glutamine and D-glutamate metabolism:Aminobenzoate degradation:Folate biosynthesis:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Protein export:Bacterial secretion system:General function prediction only:Function unknown:ncs2:agcS:tatC:LPXTG_anchor:tatAE:nitri_red_nirB:Gln_ase:export_SdpA:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Central intermediary metabolism:Nitrogen metabolism:Energy metabolism:Amino acids and amines:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Nucleosides, purines and pyrimidines:Cell envelope:Other:Metabolism:Metabolism:Poorly characterized" 306 "Energy production and conversion:3-oxoacyl-(acyl-carrier-protein) synthase:(acyl-carrier-protein) S-malonyltransferase:Thiol-disulfide isomerase and thioredoxins:Predicted Fe-S oxidoreductases:Non-ribosomal peptide synthetase modules and related proteins:Enoyl-CoA hydratase/carnithine racemase:Disulfide bond formation protein DsbB:D-alanyl-D-alanine carboxypeptidase:ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain:Erythromycin esterase homolog:Polyketide synthase modules and related proteins:3-hydroxy-3-methylglutaryl CoA synthase:Uncharacterized protein conserved in bacteria:N-acetylmuramoyl-L-alanine amidase:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Fatty acid metabolism:Synthesis and degradation of ketone bodies:Valine leucine and isoleucine degradation:Geraniol degradation:Lysine degradation:Benzoate degradation:Tryptophan metabolism:beta-Alanine metabolism:Peptidoglycan biosynthesis:Aminobenzoate degradation:Propanoate metabolism:Butanoate metabolism:Terpenoid backbone biosynthesis:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:fabD:NRPS-para261:AA-adenyl-dom:export_SdpB:export_SdpA:rSAM_yydG:Defense mechanisms:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism:Metabolism of Terpenoids and Polyketides:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Metabolism:Carbohydrate Metabolism:Poorly characterized:Cellular processes and signaling:Protein interactions:Regulatory functions" 307 "3-oxoacyl-[acyl-carrier-protein] synthase III:Uncharacterized conserved protein:Amidases related to nicotinamidase:Uncharacterized conserved protein:Predicted membrane protein/domain:Cytochrome P450:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Predicted membrane protein:Predicted ring-cleavage extradiol dioxygenase:Lysophospholipase L1 and related esterases:Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis:Arabinose efflux permease:Uncharacterized protein conserved in bacteria:Ketosteroid isomerase-related protein:Signal transduction histidine kinase:Predicted permease, DMT superfamily:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Fatty acid biosynthesis:Biosynthesis of siderophore group nonribosomal peptides:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00294:fabH:toxin_SdpC:Information storage and processing:Conserved:Hypothetical proteins:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Global:Metabolism of Terpenoids and Polyketides:Metabolism:Lipid Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling" 308 "Transcriptional regulators:Transcriptional regulators:ABC-type sugar transport systems, ATPase components:Carbohydrate transport and metabolism:Transcription:Information storage and processing:Metabolism" 309 "3-oxoacyl-(acyl-carrier-protein) synthase:3-oxoacyl-[acyl-carrier-protein] synthase III:DNA primase (bacterial type):Fatty acid/phospholipid biosynthesis enzyme:Topoisomerase IA:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):Enoyl-[acyl-carrier-protein] reductase (NADH):Predicted xylanase/chitin deacetylase:Periplasmic protease:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Cold shock proteins:Uncharacterized protein conserved in bacteria:Nucleoside permease:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Predicted metal-binding protein related to the C-terminal domain of SecA:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Fatty acid biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Two-component system:RNA polymerase:DNA replication:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:plsX:prc:fabH:nupC:topB:dnaG:3oxo_ACP_reduc:RpoD_Cterm:spo_ytxC:fabF:Fatty acid and phospholipid metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Replication and Repair:Metabolism:Transcription:Genetic Information Processing:DNA metabolism:Lipid Metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein fate:Protein modification and repair:Transport and binding proteins:Nucleosides, purines and pyrimidines:Cellular processes:Sporulation and germination:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis" 310 "Energy production and conversion:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Predicted hydrolases of the HAD superfamily:K+ transport systems, NAD-binding component:Signal transduction histidine kinase:Predicted dehydrogenases and related proteins:Fucose permease:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Glutamate racemase:Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis):Acylphosphatases:Transcriptional regulators:FOG: GGDEF domain:Putative NADPH-quinone reductase (modulator of drug activity B):Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides:Regulator of polyketide synthase expression:Arabinose efflux permease:Signal transduction histidine kinase, nitrogen specific:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase:Uncharacterized protein conserved in bacteria:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:D-Glutamine and D-glutamate metabolism:Pyruvate metabolism:Aminobenzoate degradation:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:glut_race:RNAse_H_YqgF:GGDEF:SP:tatAE:HAD-SF-IIB:excise:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Other Amino Acids:Biosynthesis and degradation of murein sacculus and peptidoglycan:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cell envelope:Other:Signal transduction:General:Enzymes of unknown specificity:Unknown function:Carbohydrates, organic alcohols, and acids" 311 "Ribonuclease HI:Zn-dependent hydrolases, including glyoxylases:Superfamily II DNA helicase:Predicted hydrolases of the HAD superfamily:Na+/proline symporter:Predicted dehydrogenases and related proteins:Fucose permease:Ribonuclease HIII:Gamma-aminobutyrate permease and related permeases:Uncharacterized conserved protein:Predicted transcriptional regulator:Regulators of stationary/sporulation gene expression:Sugar phosphate permease:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Peptidase E:Uncharacterized protein conserved in bacteria:Predicted integral membrane protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:RNA degradation:DNA replication:General function prediction only:Function unknown:recQ_fam:TIGR00697:rnhC:rrf2_super:2A0306:lp_hng_hel_AbrB:HAD-SF-IIB:Poorly characterized:Folding Sorting and Degradation:Replication and Repair:Regulatory functions:DNA interactions:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Amino acids, peptides and amines:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:General:Information storage and processing:Metabolism:Genetic Information Processing" 312 "Ammonia permease:Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:Dihydrodipicolinate reductase:Lactoylglutathione lyase and related lyases:tRNA nucleotidyltransferase/poly(A) polymerase:Permeases of the drug/metabolite transporter (DMT) superfamily:Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Predicted ATPase or kinase:ABC-type multidrug transport system, ATPase component:Inactive homolog of metal-dependent proteases, putative molecular chaperone:Phytoene/squalene synthetase:Predicted pyrophosphatase:Methylglyoxal synthase:GTPases:Uncharacterized conserved protein:Sugar diacid utilization regulator:Cystathionine beta-lyase family protein involved in aluminum resistance:Putative virion core protein (lumpy skin disease virus):Nitric oxide synthase, oxygenase domain:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Lysine biosynthesis:Arginine and proline metabolism:Pyruvate metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:Signal transduction mechanisms:dapB:gatA:gatC:HI0065_YjeE:MGSA:amt:parE_Gpos:parC_Gpos:GTP_HflX:bact_YeaZ:Defense mechanisms:Aspartate family:Carbohydrate Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Other:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Cations and iron carrying compounds:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 313 "Energy production and conversion:Prephenate dehydratase:FAD/FMN-containing dehydrogenases:Predicted hydrolase of the metallo-beta-lactamase superfamily:Phosphopantetheine adenylyltransferase:Signal peptidase I:Preprotein translocase subunit YidC:N6-adenine-specific methylase:Purine-nucleoside phosphorylase:Membrane-fusion protein:Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold:ABC-type multidrug transport system, ATPase component:Metal-dependent amidase/aminoacylase/carboxypeptidase:Beta-propeller domains of methanol dehydrogenase type:Type II secretory pathway, pullulanase PulA and related glycosidases:Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase:ABC-type Na+ efflux pump, permease component:Beta-lactamase class C and other penicillin binding proteins:Predicted RNA-binding protein:Uncharacterized protein conserved in bacteria:Tetrahydrodipicolinate N-succinyltransferase:Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB:Predicted glycosyl hydrolase:ABC-type uncharacterized transport system, ATPase component:Predicted membrane protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Lysine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Glycerolipid metabolism:Nicotinate and nicotinamide metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:RNA degradation:Protein export:Bacterial secretion system:General function prediction only:Function unknown:TIGR00095:deoD:cyt_tran_rel:TIGR00147:MG423:flhB_rel:RND_mfp:amidohydrolases:pulA_typeI:sigpep_I_bact:DapD_Ac:yidC_oxa1_cterm:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Protein and peptide secretion and trafficking:Lipid Metabolism:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Unknown substrate:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Protein fate:tRNA and rRNA base modification:Protein synthesis:Salvage of nucleosides and nucleotides:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global" 314 "Energy production and conversion:Superfamily I DNA and RNA helicases:Glycerol-3-phosphate dehydrogenase:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division:NAD/FAD-utilizing enzyme apparently involved in cell division:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:Predicted GTPase:Alanine racemase:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Predicted GTPases:Mismatch repair ATPase (MutS family):A/G-specific DNA glycosylase:Metal-dependent hydrolases of the beta-lactamase superfamily I:Disulfide bond chaperones of the HSP33 family:Putative transcriptional regulator, homolog of Bvg accessory factor:Predicted phosphate-binding enzymes, TIM-barrel fold:DNA polymerase IV (family X):Predicted hydrolase of the HAD superfamily:Mg/Co/Ni transporter MgtE (contains CBS domain):Tfp pilus assembly protein PilF:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:D-Alanine metabolism:Glycerophospholipid metabolism:Thiamine metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Base excision repair:Nucleotide excision repair:Mismatch repair:Sulfur relay system:General function prediction only:Function unknown:gidA:gidB:small_GTP:mgtE:trmU:alr:baf:mutS2:pcrA:mutY:HAD-SF-IA-v1:GGGP-family:GTPase_YqeH:Intracellular trafficking, secretion, and vesicular transport:Cations and iron carrying compounds:Transport and binding proteins:tRNA and rRNA base modification:Other:Protein synthesis:DNA replication, recombination, and repair:Other:DNA metabolism:Metabolism:Metabolism:Global:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Cellular processes and signaling:Lipid Metabolism:Metabolism:Poorly characterized:Information storage and processing:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope:Pantothenate and coenzyme A:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Enzymes of unknown specificity:Unknown function" 315 "Energy production and conversion:D-Tyr-tRNAtyr deacylase:Transcriptional regulators:Cytochrome c, mono- and diheme variants:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase:Dipeptide/tripeptide permease:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Phenylalanine tyrosine and tryptophan biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:TIGR00256:yjdL_sub1_fam:DAHP_synth_Bsub:Amino acids, peptides and amines:Amino Acid Metabolism:Global:Metabolism:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Metabolism:Amino acid biosynthesis:Aromatic amino acid family:Information storage and processing:Metabolism" 316 "Predicted membrane protein/domain:Uncharacterized protein conserved in bacteria:Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta):Lipid transport and metabolism:Valine leucine and isoleucine degradation:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Microbial metabolism in diverse environments:Function unknown:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Global:Metabolism:Metabolism:Poorly characterized" 317 "Energy production and conversion:Geranylgeranyl pyrophosphate synthase:Aspartate/tyrosine/aromatic aminotransferase:Acetyltransferases:Hypoxanthine-guanine phosphoribosyltransferase:F0F1-type ATP synthase, subunit b:ABC-type molybdate transport system, periplasmic component:Glycosyltransferases, probably involved in cell wall biogenesis:Predicted transcriptional regulator containing the HTH domain:ABC-type metal ion transport system, periplasmic component/surface antigen:Integral membrane protein CcmA involved in cell shape determination:Regulators of stationary/sporulation gene expression:Uncharacterized conserved protein:Predicted secreted protein containing a PDZ domain:Uncharacterized protein conserved in bacteria:Predicted oxidoreductase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Lysine biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00281:ATP_synt_b:HGPRTase:modA:lp_hng_hel_AbrB:Information storage and processing:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:Regulatory functions:DNA interactions:DNA metabolism:Chromosome-associated proteins:Transport and binding proteins:Anions:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 318 "Energy production and conversion:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Mannitol-1-phosphate/altronate dehydrogenases:Zn-dependent hydrolases, including glyoxylases:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:ABC-type multidrug transport system, permease component:NAD-dependent aldehyde dehydrogenases:ABC-type multidrug transport system, ATPase component:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulator:Transcriptional regulators:Membrane transporters of cations and cationic drugs:Transcriptional regulators:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:FOG: GAF domain:Xanthine/uracil permeases:Altronate dehydratase:Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase:Arabinose efflux permease:Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation):Predicted signal transduction protein with a C-terminal ATPase domain:Signal transduction histidine kinase:Bacteriophage capsid portal protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Fatty acid metabolism:Purine metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Propanoate metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Phosphotransferase system (PTS):General function prediction only:Signal transduction mechanisms:ncs2:sortase_fam:portal_PBSX:hydantase:Defense mechanisms:Mobile and extrachromosomal element functions:Nucleosides, purines and pyrimidines:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Prophage functions:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Global:Metabolism:Signal Transduction:Poorly characterized:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism" 319 "tRNA-dihydrouridine synthase:Predicted rRNA methylase (SpoU class):CTP synthase (UTP-ammonia lyase):Amino acid transporters:Na+-driven multidrug efflux pump:Predicted hydrolases of the HAD superfamily:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Organic radical activating enzymes:Membrane-associated phospholipid phosphatase:6-pyruvoyl-tetrahydropterin synthase:Amino acid transporters:Branched-chain amino acid permeases:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase:Rad3-related DNA helicases:Transcriptional regulators of sugar metabolism:Predicted membrane-bound metal-dependent hydrolases:Predicted permease:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Predicted membrane protein:Predicted carboxypeptidase:Predicted membrane protein:Predicted membrane protein:Signal transduction histidine kinase:Predicted membrane protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Ubiquinone and other terpenoid-quinone biosynthesis:Pyrimidine metabolism:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:6PTHBS:Cof-subfamily:menD:rRNA_methyl_2:PyrG:livcs:matE:thia_yuaJ:Bsubt_queE:Defense mechanisms:Nucleotide Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Unknown function:Other:Amino acids, peptides and amines:Transport and binding proteins:tRNA and rRNA base modification:Protein synthesis:Pyrimidine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Enzymes of unknown specificity" 320 "Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Peptidyl-tRNA hydrolase:Glycosyltransferases involved in cell wall biogenesis:Predicted dehydrogenases and related proteins:DNA-binding ferritin-like protein (oxidative damage protectant):DNA-directed RNA polymerase specialized sigma subunit:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Arsenate reductase and related proteins, glutaredoxin family:DnaK suppressor protein:Ribosomal protein L25 (general stress protein Ctc):N-Dimethylarginine dimethylaminohydrolase:Anti-sigma regulatory factor (Ser/Thr protein kinase):Gluconolactonase:Uncharacterized stress protein (general stress protein 26):Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain:Gas vesicle protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pyruvate metabolism:Metabolic pathways:Ribosome:RNA polymerase:General function prediction only:Signal transduction mechanisms:ant_ant_sig:pth:ctc_TL5:arsC_related:rsbW_low_gc:sigma70-ECF:B_thiol_YtxJ:Cellular processes and signaling:Carbohydrate Metabolism:Genetic Information Processing:Transcription:Translation:Global:Metabolism:Regulatory functions:DNA interactions:Protein interactions:Protein synthesis:Other:Ribosomal proteins: synthesis and modification:Unknown function:Enzymes of unknown specificity:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 321 "Chromatin structure and dynamics:Deacetylases, including yeast histone deacetylase and acetoin utilization protein:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Glycosidases:FOG: CBS domain:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Phosphotransferase system cellobiose-specific component IIB:Phosphotransferase system cellobiose-specific component IIA:Phosphotransferase system cellobiose-specific component IIC:Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases:Transcriptional regulators:Na+/melibiose symporter and related transporters:Transcriptional activator of acetoin/glycerol metabolism:Beta-xylosidase:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Glycolysis / Gluconeogenesis:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Phosphotransferase system (PTS):Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:cello_pts_IIC:gph:EIIA-LAC:EIIB_glc:pts-lac:2A0309:trehalose_treC:trehalos_R_Bsub:spore_ger_x_C:Information storage and processing:Carbohydrate Metabolism:Energy Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Regulatory functions:DNA interactions:Transport and binding proteins:Amino acids, peptides and amines:Carbohydrates, organic alcohols, and acids:Cellular processes:Sporulation and germination:Signal transduction:PTS:Metabolism:Metabolism:Poorly characterized" 322 "Glutamate-1-semialdehyde aminotransferase:Diaminopimelate decarboxylase:Superfamily II DNA and RNA helicases:Predicted xylanase/chitin deacetylase:Nucleoside phosphorylase:Glutamate racemase:HD superfamily phosphohydrolases:Gamma-aminobutyrate permease and related permeases:Cold shock proteins:Transcriptional regulators:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:SH3 domain protein:Predicted metal-binding protein related to the C-terminal domain of SecA:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cysteine and methionine metabolism:Lysine biosynthesis:D-Glutamine and D-glutamate metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:glut_race:hemL:lysA:MTA/SAH-Nsdase:spo_ytxC:Sporulation and germination:Cellular processes:Salvage of nucleosides and nucleotides:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Heme, porphyrin, and cobalamin:Amino Acid Metabolism:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Aspartate family:Amino acid biosynthesis" 323 "Energy production and conversion:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Pyrroline-5-carboxylate reductase:Rhodanese-related sulfurtransferase:Mannose-6-phosphate isomerase:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):NAD-dependent aldehyde dehydrogenases:Sugar (pentulose and hexulose) kinases:Acylphosphatases:Transcriptional regulators of sugar metabolism:Acetyltransferases, including N-acetylases of ribosomal proteins:Transcriptional regulators:Transcriptional regulator/sugar kinase:Glutaminase:Uncharacterized protein conserved in bacteria:Beta-xylosidase:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Gas vesicle protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose and glucuronate interconversions:Galactose metabolism:Ascorbate and aldarate metabolism:Fatty acid metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:D-Glutamine and D-glutamate metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Aminobenzoate degradation:Propanoate metabolism:Limonene and pinene degradation:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:ROK_glcA_fam:gntK_FGGY:Gln_ase:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Metabolism:General:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Unknown function:Sugars:Amino acids and amines:Energy metabolism:Metabolism:Global:Xenobiotics Biodegradation and Metabolism:Biosynthesis of Other Secondary Metabolites" 324 "Energy production and conversion:Predicted sugar kinase:FAD synthase:Malic enzyme:ABC-type transport system involved in Fe-S cluster assembly, ATPase component:Peroxiredoxin:Selenocysteine lyase:Exopolyphosphatase-related proteins:ABC-type transport system involved in Fe-S cluster assembly, permease component:Parvulin-like peptidyl-prolyl isomerase:NifU homolog involved in Fe-S cluster formation:Predicted thioesterase:Membrane protein TerC, possibly involved in tellurium resistance:Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog):ATP-dependent protease Clp, ATPase subunit:Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1:Septum formation initiator:Alkyl hydroperoxide reductase, large subunit:Uncharacterized protein involved in tellurite resistance:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Selenocompound metabolism:Pyruvate metabolism:Thiamine metabolism:Riboflavin metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00051:ribF:clpX:sufC:sufS:sufB:sufD:SUF_scaf_2:spore_yabP:spore_yabQ:AhpC:AhpF:R_switched_YkoY:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Riboflavin, FMN, and FAD:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Unknown function:Sporulation and germination:Adaptations to atypical conditions:Cellular processes:Degradation of proteins, peptides, and glycopeptides:Protein fate:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Carbohydrate Metabolism" 325 "Undecaprenyl pyrophosphate synthase:Uracil phosphoribosyltransferase:S-adenosylmethionine synthetase:Superfamily I DNA and RNA helicases:Asparagine synthase (glutamine-hydrolyzing):Phosphoribosylpyrophosphate synthetase:Signal recognition particle GTPase:ABC-type Fe3+-siderophore transport system, permease component:Signal transduction histidine kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:UDP-N-acetylglucosamine enolpyruvyl transferase:Actin-like ATPase involved in cell morphogenesis:Gamma-aminobutyrate permease and related permeases:ABC-type antimicrobial peptide transport system, ATPase component:N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains):FOG: GGDEF domain:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose phosphate pathway:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:D-Alanine metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Terpenoid backbone biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Protein export:Bacterial secretion system:Nucleotide excision repair:Mismatch repair:Function unknown:Signal transduction mechanisms:uppS:GGDEF:mreB:ffh:metK:murA:upp:glmU:ribP_PPkin:asn_synth_AEB:dltC:int_mem_ywzB:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Amino sugars:Other:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Salvage of nucleosides and nucleotides:Protein fate:Protein and peptide secretion and trafficking:Amino acid biosynthesis:Aspartate family:Signal transduction:Other:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 326 "Energy production and conversion:Arginase/agmatinase/formimionoglutamate hydrolase, arginase family:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Amino acid transporters:ABC-type multidrug transport system, permease component:NAD-dependent aldehyde dehydrogenases:Na+/H+ antiporter NhaD and related arsenite permeases:Threonine dehydrogenase and related Zn-dependent dehydrogenases:ABC-type multidrug transport system, ATPase component:Imidazolonepropionase and related amidohydrolases:Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs:Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs:Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs:Putative multicopper oxidases:Na+/melibiose symporter and related transporters:Altronate dehydratase:Arabinose efflux permease:Histidine ammonia-lyase:Urocanate hydratase:Patatin:L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Fructose and mannose metabolism:Ascorbate and aldarate metabolism:Fatty acid metabolism:Purine metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Propanoate metabolism:Limonene and pinene degradation:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:gph:hutI:hutH:hutG:hutU:tiny_TM_bacill:pucD:pucE:pucC:galactar-dH20:KdgD:Defense mechanisms:Conserved:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Amino acids and amines:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Hypothetical proteins:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 327 "Uncharacterized conserved protein:Zn-dependent hydrolases, including glyoxylases:Predicted hydrolases of the HAD superfamily:Glycine/D-amino acid oxidases (deaminating):DNA or RNA helicases of superfamily II:Branched-chain amino acid permeases:Transcriptional regulator:Transcriptional regulators of sugar metabolism:Transcriptional regulators:Uncharacterized conserved protein:Homoserine trans-succinylase:Predicted transcriptional regulator:Chromate transport protein ChrA:Arabinose efflux permease:Predicted periplasmic or secreted protein:Predicted membrane protein:Uncharacterized integral membrane protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:Function unknown:Cof-subfamily:rrf2_super:livcs:metA:TIGR01033:SASP_gamma:spore_YlmC_YmxH:Amino acid biosynthesis:General:Enzymes of unknown specificity:Unknown function:Sporulation and germination:Cellular processes:Amino acids, peptides and amines:Transport and binding proteins:DNA interactions:Regulatory functions:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Amino Acid Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Information storage and processing:Aspartate family" 328 "Energy production and conversion:Fructose/tagatose bisphosphate aldolase:Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases:Glycerol dehydrogenase and related enzymes:ABC-type sugar transport system, permease component:Sugar kinases, ribokinase family:Predicted dehydrogenases and related proteins:NAD-dependent aldehyde dehydrogenases:Sugar phosphate isomerases/epimerases:ABC-type sugar transport system, periplasmic component:Na+/melibiose symporter and related transporters:Sugar phosphate permease:Predicted signal transduction protein with a C-terminal ATPase domain:Alpha-L-arabinofuranosidase:Uncharacterized enzyme involved in inositol metabolism:Acetolactate synthase:Predicted integral membrane protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Pentose and glucuronate interconversions:Valine leucine and isoleucine degradation:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Inositol phosphate metabolism:Propanoate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:cbbA:araD:SP:MMSDH:Poorly characterized:Metabolism:Cellular processes and signaling:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Sugars:Glycolysis/gluconeogenesis:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Biosynthesis of Other Secondary Metabolites:Amino Acid Metabolism:Carbohydrate Metabolism" 329 "Energy production and conversion:3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:3-polyprenyl-4-hydroxybenzoate decarboxylase:Glutamate dehydrogenase/leucine dehydrogenase:Amino acid transporters:NAD-dependent aldehyde dehydrogenases:Sortase and related acyltransferases:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Beta-fructosidases (levanase/invertase):Beta-lactamase class C and other penicillin binding proteins:Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein:Aspartate racemase:Transcriptional regulators:Thermophilic glucose-6-phosphate isomerase and related metalloenzymes:Sugar phosphate permease:Beta-glucanase/Beta-glucan synthetase:Erythromycin esterase homolog:Arabinose efflux permease:Phosphotransferase system, mannose/fructose-specific component IIA:Na+/citrate symporter:Arginine degradation protein (predicted deacylase):Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Ubiquinone and other terpenoid-quinone biosynthesis:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Glyoxylate and dicarboxylate metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Phosphotransferase system (PTS):General function prediction only:asp_race:TIGR00148:ubiX_pad:ccs:EIIA-man:EIIB_glc:SP:2A0114:D1pyr5carbox2:bicupin_oxalic:Defense mechanisms:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:General:Carbohydrate Metabolism:Unclassified:Role category not yet assigned:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Enzymes of unknown specificity:Unknown function:Carbohydrates, organic alcohols, and acids:Transport and binding proteins" 330 "Chromatin structure and dynamics:Energy production and conversion:Deacetylases, including yeast histone deacetylase and acetoin utilization protein:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Mannitol-1-phosphate/altronate dehydrogenases:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:FOG: CBS domain:Glycerol kinase:Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family):Sugar (pentulose and hexulose) kinases:ABC-type sugar transport systems, permease components:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Transcriptional regulators of sugar metabolism:L-lactate permease:Transcriptional regulators:Regulator of polyketide synthase expression:Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase:Uncharacterized conserved protein:Uncharacterized conserved protein:L-rhamnose isomerase:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Fructose and mannose metabolism:Fatty acid metabolism:Cyanoamino acid metabolism:Starch and sucrose metabolism:Glycerolipid metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Phosphotransferase system (PTS):Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:lctP:EIIB_glc:PTBA:MIP:glycerol_kin:rhaA:YiiL_rotase:rhamnulo_kin:RhaD_aldol-ADH:Membrane Transport:Environmental Information Processing:Metabolism of Other Amino Acids:Lipid Metabolism:Carbohydrates, organic alcohols, and acids:Carbohydrate Metabolism:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Unknown substrate:Transport and binding proteins:Sugars:Other:Energy metabolism:Metabolism:Metabolism:Global" 331 "dUTPase:Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase:Phage-related protein:Site-specific recombinase XerD:N-acetylmuramoyl-L-alanine amidase:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Pyrimidine metabolism:Metabolic pathways:Function unknown:holin_SPP1:Metabolism:Nucleotide Metabolism:Global:Metabolism:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 332 "" 333 "Energy production and conversion:FAD synthase:Transcriptional regulator:Glutaredoxin and related proteins:Predicted permeases:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type polar amino acid transport system, ATPase component:Metal-dependent amidase/aminoacylase/carboxypeptidase:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:ABC-type arginine/histidine transport system, permease component:Amino acid transport and metabolism:Coenzyme transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:General function prediction only:Signal transduction mechanisms:HEQRo_perm_3TM:amidohydrolases:oxido_grp_1:FMN_nitrolo:Information storage and processing:Enzymes of unknown specificity:Unknown function:Amino acids, peptides and amines:Transport and binding proteins:Degradation of proteins, peptides, and glycopeptides:Protein fate:Metabolism:Poorly characterized:Cellular processes and signaling" 334 "Energy production and conversion:Aspartate-semialdehyde dehydrogenase:Lactoylglutathione lyase and related lyases:6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase:Protein-tyrosine-phosphatase:Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain:Glycine cleavage system T protein (aminomethyltransferase):Superfamily II DNA helicase:NADPH:quinone reductase and related Zn-dependent oxidoreductases:Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain:Flagellar biosynthesis/type III secretory pathway protein:Methylase of chemotaxis methyl-accepting proteins:Flagellar motor switch protein:Flagellar basal body rod protein:Flagellar hook-basal body protein:Flagellar biosynthesis/type III secretory pathway lipoprotein:Flagellar basal body protein:N-acetylglucosamine-6-phosphate deacetylase:Nucleoside permease:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Transcriptional regulators:Sugar phosphate permease:Zinc metalloprotease (elastase):Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell motility:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Amino sugar and nucleotide sugar metabolism:One carbon pool by folate:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Flagellar assembly:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:fliE:fliF:fliG:nagA:unchar_dom_1:nagB:gcvT:recQ_fam:nupC:asd_B:FlgC:FlgB:FliH_bacil:Intracellular trafficking, secretion, and vesicular transport:Chemotaxis and motility:Cellular processes:Nucleosides, purines and pyrimidines:Transport and binding proteins:DNA replication, recombination, and repair:DNA metabolism:Amino acids and amines:Energy metabolism:Amino sugars:Central intermediary metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Metabolism:Carbohydrate Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing:Aspartate family:Amino acid biosynthesis" 335 "Predicted Zn-dependent peptidases:Non-ribosomal peptide synthetase modules and related proteins:ABC-type multidrug transport system, ATPase component:Deoxyinosine 3'endonuclease (endonuclease V):Arabinose efflux permease:Carbohydrate transport and metabolism:Replication, recombination and repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:NRPS-para261:Defense mechanisms:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing" 336 "Energy production and conversion:FAD synthase:ABC-type nitrate/sulfonate/bicarbonate transport system, permease component:ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:Metal-dependent amidase/aminoacylase/carboxypeptidase:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:ABC-type arginine/histidine transport system, permease component:Amino acid transport and metabolism:Coenzyme transport and metabolism:Inorganic ion transport and metabolism:ABC transporters:General function prediction only:Signal transduction mechanisms:HEQRo_perm_3TM:SsuA_fam:amidohydrolases:oxido_grp_1:alk_sulf_monoox:FMN_nitrolo:Cellular processes and signaling:Membrane Transport:Central intermediary metabolism:Sulfur metabolism:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Amino acids, peptides and amines:Other:Unknown function:Enzymes of unknown specificity:Environmental Information Processing:Metabolism:Poorly characterized" 337 "Nucleotidyltransferase/DNA polymerase involved in DNA repair:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase:Phage-related protein:Site-specific recombinase XerD:N-acetylmuramoyl-L-alanine amidase:Carbohydrate transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Function unknown:holin_SPP1:Information storage and processing:Prophage functions:Mobile and extrachromosomal element functions:Poorly characterized:Metabolism:Cellular processes and signaling" 338 "" 339 "ABC-type uncharacterized transport system, permease component:Amino acid transporters:rRNA methylases:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Predicted hydrolase (HAD superfamily):Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold:ABC-type phosphate transport system, ATPase component:ABC-type multidrug transport system, ATPase component:ABC-type multidrug transport system, ATPase and permease components:ABC-type antimicrobial peptide transport system, ATPase component:Predicted branched-chain amino acid permease (azaleucine resistance):Predicted transcriptional regulators:Transcriptional regulators:Predicted branched-chain amino acid permeases (azaleucine resistance):Predicted transcriptional regulators:Transcriptional regulators:Arabinose efflux permease:Predicted membrane protein:Putative regulator of cell autolysis:Response regulator of the LytR/AlgR family:Uncharacterized protein conserved in bacteria:Capsular polysaccharide biosynthesis protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00245:azlC:efflux_EmrB:HAD-SF-IA-v3:menH_SHCHC:Defense mechanisms:Enzymes of unknown specificity:Unknown function:Conserved:Hypothetical proteins:Other:Amino acids, peptides and amines:Transport and binding proteins:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Poorly characterized:Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Menaquinone and ubiquinone:Biosynthesis of cofactors, prosthetic groups, and carriers" 340 "Energy production and conversion:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit:Tyrosyl-tRNA synthetase:Phosphotransacetylase:Glutamate dehydrogenase/leucine dehydrogenase:Peroxiredoxin:Zn-dependent hydrolases, including glyoxylases:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:Predicted dehydrogenases and related proteins:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type transport system involved in cytochrome c biogenesis, permease component:Threonine dehydrogenase and related Zn-dependent dehydrogenases:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:ResB protein required for cytochrome c biosynthesis:Uncharacterized protein conserved in bacteria:Transcriptional regulator, contains sigma factor-related N-terminal domain:Uncharacterized conserved protein:Signal transduction histidine kinase regulating citrate/malate metabolism:Uncharacterized anaerobic dehydrogenase:Butyrate kinase:Signal transduction histidine kinase:Uncharacterized conserved protein:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Butanoate metabolism:Methane metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:tyrS:lipoamide_DH:Fdh-alpha:P_butyryltrans:butyr_kinase:cytochr_II_ccsB:Cellular processes and signaling:Information storage and processing:Protein modification and repair:Protein fate:tRNA aminoacylation:Protein synthesis:Fermentation:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Translation:Genetic Information Processing:Amino Acid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism" 341 "Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:NTP pyrophosphohydrolases including oxidative damage repair enzymes:SAM-dependent methyltransferases:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Transcriptional regulators:Arabinose efflux permease:Alpha-acetolactate decarboxylase:Predicted ABC-type exoprotein transport system, permease component:L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Ubiquinone and other terpenoid-quinone biosynthesis:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Starch and sucrose metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:acetolac_decarb:dipeptidaselike:menE:menC_lowGC/arch:acolac_catab:sigma70-ECF:Intracellular trafficking, secretion, and vesicular transport:Menaquinone and ubiquinone:Biosynthesis of cofactors, prosthetic groups, and carriers:Fermentation:Energy metabolism:Metabolism:Metabolism:Global:Transcription:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing" 342 "Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Cell wall-associated hydrolases (invasion-associated proteins):Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Carbon storage regulator (could also regulate swarming and quorum sensing):Uncharacterized protein conserved in bacteria:Beta- N-acetylglucosaminidase:Flagellar basal body rod protein:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Uncharacterized conserved protein:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Other glycan degradation:Two-component system:Bacterial chemotaxis:Flagellar assembly:Function unknown:Signal transduction mechanisms:csrA:GGDEF:FlgEFG_subfam:Cellular processes and signaling:Glycan Biosynthesis and Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Regulatory functions:RNA interactions:Signal transduction:Other:Metabolism:Metabolism:Poorly characterized" 343 "Energy production and conversion:Phenylalanyl-tRNA synthetase alpha subunit:Undecaprenyl pyrophosphate synthase:Phenylalanyl-tRNA synthetase beta subunit:Chorismate synthase:Acyl carrier protein:Folylpolyglutamate synthase:3-oxoacyl-(acyl-carrier-protein) synthase:(acyl-carrier-protein) S-malonyltransferase:3-oxoacyl-[acyl-carrier-protein] synthase III:3-dehydroquinate synthetase:Fatty acid/phospholipid biosynthesis enzyme:Valyl-tRNA synthetase:dsRNA-specific ribonuclease:CDP-diglyceride synthetase:UDP-N-acetylglucosamine enolpyruvyl transferase:Heme/copper-type cytochrome/quinol oxidases, subunit 1:Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins:Heme/copper-type cytochrome/quinol oxidases, subunit 2:Heme/copper-type cytochrome/quinol oxidase, subunit 3:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Heme/copper-type cytochrome/quinol oxidase, subunit 4:Chorismate mutase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Fatty acid biosynthesis:Oxidative phosphorylation:Valine leucine and isoleucine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:Folate biosynthesis:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:aroC:uppS:fabD:plsX:glpX:valS:pheS:pheT_bact:acyl_carrier:fabH:murA:aroB:QOXA:folC:CM_mono_aroH:RNaseIII:QoxB:QoxC:QoxD:fabF:Folic acid:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Global:Metabolism:Energy metabolism:Electron transport:Pentose phosphate pathway:Fatty acid and phospholipid metabolism:Biosynthesis:Transcription:RNA processing:Protein synthesis:tRNA aminoacylation:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism" 344 "Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Glutamate 5-kinase:Pyrroline-5-carboxylate reductase:Uncharacterized ABC-type transport system, permease component:ABC-type uncharacterized transport systems, ATPase components:ABC-type uncharacterized transport system, permease component:Amino acid transport and metabolism:Coenzyme transport and metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:proC:proB:ilvE_II:toxin_SdpC:Poorly characterized:Metabolism:Pyruvate family:Glutamate family:Amino acid biosynthesis:Metabolism:Metabolism:Global:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism" 345 "" 346 "" 347 "" 348 "" 349 "Energy production and conversion:ABC-type phosphate transport system, periplasmic component:ABC-type sugar transport system, permease component:Glycosyltransferase:Glycosyltransferases involved in cell wall biogenesis:ATPases involved in chromosome partitioning:Sugar kinases, ribokinase family:ABC-type phosphate transport system, permease component:ABC-type phosphate transport system, permease component:Predicted UDP-glucose 6-dehydrogenase:ABC-type phosphate transport system, ATPase component:ABC-type sugar transport systems, permease components:Cytochrome bd-type quinol oxidase, subunit 2:ABC-type sugar transport system, periplasmic component:Predicted phosphosugar isomerases:Membrane protein involved in the export of O-antigen and teichoic acid:Capsular polysaccharide biosynthesis protein:ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components:ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Oxidative phosphorylation:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:General function prediction only:cydB:3a0107s01c2:3a0107s02c:eps_fam:ptsS_2:phosphate_pstC:CydD:CydC:NDP-sugDHase:Carbohydrates, organic alcohols, and acids:Anions:Transport and binding proteins:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling" 350 "Energy production and conversion:3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Glycine/D-amino acid oxidases (deaminating):Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Beta-glucosidase-related glycosidases:Beta-lactamase class C and other penicillin binding proteins:Uncharacterized conserved protein:Transcriptional regulators:Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein:Predicted sugar phosphate isomerase:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase:Predicted permease, DMT superfamily:Predicted Zn-dependent protease:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Amino sugar and nucleotide sugar metabolism:ABC transporters:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00148:sensory_box:TIGR00274:oligo_HPY:Defense mechanisms:Small molecule interactions:Regulatory functions:Signal Transduction:Membrane Transport:Environmental Information Processing:Carbohydrate Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope:Metabolism:General:Unknown function:Amino acids, peptides and amines:Transport and binding proteins" 351 "" 352 "Ca2+/H+ antiporter:Protein-tyrosine-phosphatase:Predicted nucleoside-diphosphate sugar epimerase:Na+/alanine symporter:DNA-directed RNA polymerase specialized sigma subunit:Predicted membrane protein:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase:N-Dimethylarginine dimethylaminohydrolase:Anti-sigma regulatory factor (Ser/Thr protein kinase):Arabinose efflux permease:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycerophospholipid metabolism:Metabolic pathways:RNA polymerase:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00147:cax:yihY_not_rbn:agcS:SP:yfcH:rsbW_low_gc:sigma70-ECF:Information storage and processing:Lipid Metabolism:Genetic Information Processing:Transcription:Global:Metabolism:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:General:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 353 "Energy production and conversion:2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway):Predicted epimerase, PhzC/PhzF homolog:Acetyltransferases:Proline dehydrogenase:Transcriptional regulator:Mannose-6-phosphate isomerase:Cell wall-associated hydrolases (invasion-associated proteins):NAD-dependent aldehyde dehydrogenases:Non-ribosomal peptide synthetase modules and related proteins:Acyl carrier protein phosphodiesterase:Alkaline phosphatase:Uncharacterized protein, involved in the regulation of septum location:Carboxylesterase type B:Predicted thioesterase involved in non-ribosomal peptide biosynthesis:Zinc metalloprotease (elastase):Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Aminobenzoate degradation:Folate biosynthesis:Limonene and pinene degradation:Biosynthesis of unsaturated fatty acids:Nonribosomal peptide structures:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:sensory_box:PhzF_family:D1pyr5carbox2:AA-adenyl-dom:Metabolism:Cellular processes and signaling:Information storage and processing:Toxin production and resistance:Cellular processes:Small molecule interactions:Regulatory functions:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Poorly characterized:Lipid Metabolism" 354 "Methionine aminopeptidase:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:ATPase components of ABC transporters with duplicated ATPase domains:Signal transduction histidine kinase:Predicted transcriptional regulators:Predicted HD superfamily hydrolase:Small primase-like proteins (Toprim domain):Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted membrane-bound metal-dependent hydrolases:Uncharacterized proteins, LmbE homologs:Truncated hemoglobins:Arabinose efflux permease:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase regulating citrate/malate metabolism:Uncharacterized conserved protein:Uncharacterized domain/protein associated with RNAses G and E:Response regulator of citrate/malate metabolism:Negative regulator of genetic competence, sporulation and motility:Uncharacterized protein conserved in bacteria:Transcriptional regulator, effector-binding domain/component:Gas vesicle protein:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:HDIG:met_pdase_I:lysidine_TilS_N:thiol_BshB2:Signal Transduction:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Glutathione and analogs:Biosynthesis of cofactors, prosthetic groups, and carriers:Protein modification and repair:Protein fate:tRNA and rRNA base modification:Protein synthesis:Environmental Information Processing" 355 "Energy production and conversion:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog):3-phosphoglycerate kinase:Enolase:Triosephosphate isomerase:DNA-directed RNA polymerase, alpha subunit/40 kD subunit:Ribosomal protein L17:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:Phosphoglyceromutase:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit:Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Phosphotransferase system, HPr-related proteins:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Fructose and mannose metabolism:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Inositol phosphate metabolism:Pyruvate metabolism:Butanoate metabolism:Methane metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Phosphotransferase system (PTS):Ribosome:RNA degradation:RNA polymerase:L17:gatB:tim:PTS_HPr_family:eno:pgm_bpd_ind:lipoamide_DH:PTS_I_fam:GAPDH-I:rpoA:PDH_E1_alph_x:Pyruvate dehydrogenase:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Transcription:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Metabolism:Transcription:DNA-dependent RNA polymerase:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Signal transduction:PTS:Information storage and processing:Metabolism" 356 "Cytosine/adenosine deaminases:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type multidrug transport system, ATPase and permease components:Transcriptional regulators:Acyl-CoA dehydrogenases:Uncharacterized conserved protein:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Fatty acid biosynthesis:Purine metabolism:Biosynthesis of unsaturated fatty acids:Metabolic pathways:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Defense mechanisms:Poorly characterized:Lipid Metabolism:Nucleotide Metabolism:Genetic Information Processing:Transcription:Global:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 357 "ABC-type nitrate/sulfonate/bicarbonate transport system, permease component:Predicted membrane-associated Zn-dependent proteases 1:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Putative peptidoglycan-binding domain-containing protein:Uncharacterized protein conserved in bacteria:Putative glucose uptake permease:Spore coat protein:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose phosphate pathway:Microbial metabolism in diverse environments:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:RhaT:spore_V_AD:spore_IV_B:spore_sspJ:spore_sspO:spore_SleB:spore_YpeB:SASP_sspK:Cellular processes:Carbohydrate Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Metabolism:Sporulation and germination:Cellular processes and signaling:Metabolism:Poorly characterized" 358 "Energy production and conversion:Molecular chaperone (small heat shock protein):Peroxiredoxin:Aconitase A:Predicted membrane protein:Transcriptional regulators:Predicted phosphohydrolase (DHH superfamily):Spore coat assembly protein:Spore coat protein:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Glyoxylate and dicarboxylate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:aconitase_1:spore_V_K:Information storage and processing:Carbohydrate Metabolism:Energy Metabolism:Global:Metabolism:Energy metabolism:TCA cycle:Cellular processes:Sporulation and germination:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 359 "Energy production and conversion:Predicted sugar kinase:Dihydrofolate reductase:Peroxiredoxin:Thiol-disulfide isomerase and thioredoxins:DNA-binding ferritin-like protein (oxidative damage protectant):ABC-type multidrug transport system, ATPase and permease components:Highly conserved protein containing a thioredoxin domain:Beta-fructosidases (levanase/invertase):Uncharacterized host factor I protein:Cu/Zn superoxide dismutase:Putative NADP-dependent oxidoreductases:Permeases of the major facilitator superfamily:Carboxylesterase type B:Na+/citrate symporter:Signal transduction histidine kinase:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Galactose metabolism:Starch and sucrose metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Two-component system:RNA degradation:General function prediction only:Signal transduction mechanisms:sensory_box:ccs:scrB_fam:Hfq:expor_sig_YdyF:Defense mechanisms:Role category not yet assigned:Carbohydrate Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Regulatory functions:Other:Protein interactions:Small molecule interactions:Unclassified:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 360 "Energy production and conversion:ABC-type sugar transport system, permease component:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Predicted dehydrogenases and related proteins:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:ABC-type sugar transport systems, permease components:L-lactate permease:ABC-type sugar transport system, periplasmic component:Glycosyl transferases, related to UDP-glucuronosyltransferase:AraC-type DNA-binding domain-containing proteins:Lysophospholipase L1 and related esterases:ABC-type polysaccharide transport system, permease component:Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins:Predicted integral membrane protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:General function prediction only:Function unknown:Signal transduction mechanisms:lctP:MGT:Metabolism:Cellular processes and signaling:Information storage and processing:Toxin production and resistance:Cellular processes:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Poorly characterized" 361 "Acetyltransferase (isoleucine patch superfamily):6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase:DNA repair exonuclease:Predicted phosphatases:Signal transduction histidine kinase:Prolipoprotein diacylglyceryltransferase:Predicted nucleoside-diphosphate-sugar epimerases:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Gamma-aminobutyrate permease and related permeases:Chromosome segregation ATPases:Transcriptional regulator:Serine kinase of the HPr protein, regulates carbohydrate metabolism:TRAP-type C4-dicarboxylate transport system, periplasmic component:N-acetylglucosamine-6-phosphate deacetylase:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Predicted signal transduction protein with a C-terminal ATPase domain:Signal transduction histidine kinase regulating citrate/malate metabolism:Ketosteroid isomerase-related protein:Response regulator of citrate/malate metabolism:Signal transduction histidine kinase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Oxidative phosphorylation:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Two-component system:General function prediction only:Signal transduction mechanisms:nagA:nagB:lgt:sbcd:hpr-ser:dctP:HAD-SF-IA-v3:Information storage and processing:PTS:Signal transduction:Enzymes of unknown specificity:Unknown function:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Protein modification and repair:Protein fate:DNA replication, recombination, and repair:DNA metabolism:Amino sugars:Central intermediary metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling" 362 "" 363 "" 364 "Permeases of the drug/metabolite transporter (DMT) superfamily:Predicted transcriptional regulators:Uncharacterized conserved protein:Transcriptional regulators:Transcriptional regulators:FOG: GGDEF domain:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:ABC transporters:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:GGDEF:Signal transduction:Signal Transduction:Cellular processes and signaling:Membrane Transport:Metabolism:Poorly characterized:Environmental Information Processing:Information storage and processing:Other" 365 "Predicted Na+-dependent transporter:Zn-dependent hydrolases, including glyoxylases:Aspartokinases:Transcriptional regulator:ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Predicted redox protein, regulator of disulfide bond formation:Sugar phosphate permease:Arabinose efflux permease:Putative NADH-flavin reductase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Phosphotransferase system (PTS):General function prediction only:asp_kinases:EIIB_glc:bass:organ_hyd_perox:Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cellular processes:Detoxification:Amino acid biosynthesis:Aspartate family:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 366 "Energy production and conversion:Cell wall-associated hydrolases (invasion-associated proteins):Methyl-accepting chemotaxis protein:NAD-dependent aldehyde dehydrogenases:Flagellar motor component:Uncharacterized flagellar protein FlaG:Flagellar capping protein:Flagellar motor protein:Subtilisin-like serine proteases:Flagellin-specific chaperone FliS:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Fatty acid metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Arginine and proline metabolism:Histidine metabolism:Tryptophan metabolism:beta-Alanine metabolism:Glycerolipid metabolism:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Propanoate metabolism:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Flagellar assembly:Signal transduction mechanisms:fliS:Intracellular trafficking, secretion, and vesicular transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Metabolism:Carbohydrate Metabolism:Global:Metabolism:Cellular processes:Chemotaxis and motility:Cellular processes and signaling:Metabolism:Cell Motility:Cellular Processes:Signal Transduction" 367 "3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes:ABC-type nitrate/sulfonate/bicarbonate transport system, permease component:Periplasmic protease:Amino acid transporters:ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component:Uncharacterized conserved protein:Phosphosulfolactate phosphohydrolase and related enzymes:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Methane metabolism:Sulfur metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:prc:cysH:spore_V_AC:spore_V_AD:SASP_sspI:Cellular processes:Energy Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Sulfur metabolism:Protein fate:Protein modification and repair:Metabolism:Sporulation and germination:Cellular processes and signaling:Metabolism:Poorly characterized" 368 "" 369 "" 370 "Energy production and conversion:Anaerobic dehydrogenases, typically selenocysteine-containing:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Membrane carboxypeptidase (penicillin-binding protein):DNA or RNA helicases of superfamily II:Uncharacterized protein with SCP/PR1 domains:ATP-dependent nuclease, subunit B:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Arginine and proline metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Function unknown:DapE-ArgE:PBP_1a_fam:addB_Gpos:Cellular processes and signaling:Amino Acid Metabolism:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 371 "Energy production and conversion:ABC-type sugar transport system, permease component:Selenocysteine lyase:Predicted dehydrogenases and related proteins:DNA replication protein:ABC-type Na+ efflux pump, permease component:Regulator of polyketide synthase expression:Recombinational DNA repair protein (RecE pathway):Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins:ABC-type uncharacterized transport system, periplasmic component:Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain:Nitrate reductase alpha subunit:Phage-related protein, predicted endonuclease:Predicted integral membrane protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Replication, recombination and repair:Inorganic ion transport and metabolism:Nitrogen metabolism:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:rect:narG:phage_rel_nuc:Signal Transduction:Membrane Transport:Environmental Information Processing:Information storage and processing:Energy Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Prophage functions:Mobile and extrachromosomal element functions:Anaerobic:Energy metabolism:Metabolism:Metabolism:Global" 372 "Predicted flavoprotein:Permeases of the drug/metabolite transporter (DMT) superfamily:DNA replication protein:ABC-type sugar transport system, periplasmic component:Sec-independent protein secretion pathway components:Beta-galactosidase:AraC-type DNA-binding domain-containing proteins:Lysophospholipase L1 and related esterases:Phosphodiesterase/alkaline phosphatase D:ABC-type polysaccharide transport system, permease component:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Galactose metabolism:Other glycan degradation:Sphingolipid metabolism:Aminobenzoate degradation:Folate biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Protein export:Bacterial secretion system:General function prediction only:tatAE:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Poorly characterized:Information storage and processing:Protein and peptide secretion and trafficking:Protein fate:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Lipid Metabolism:Cellular processes and signaling:Carbohydrate Metabolism" 373 "Energy production and conversion:Peptide methionine sulfoxide reductase:Conserved domain frequently associated with peptide methionine sulfoxide reductase:N-formylmethionyl-tRNA deformylase:Methylated DNA-protein cysteine methyltransferase:ATPase components of ABC transporters with duplicated ATPase domains:Thiol-disulfide isomerase and thioredoxins:Hydrolases of the alpha/beta superfamily:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Predicted esterase of the alpha/beta hydrolase fold:Uncharacterized protein conserved in bacteria:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:General function prediction only:Function unknown:Signal transduction mechanisms:pept_deformyl:sensory_box:TIGR00357:msrA:ogt:ahpD_dom:Unknown function:Adaptations to atypical conditions:Cellular processes:Protein modification and repair:Poorly characterized:DNA replication, recombination, and repair:DNA metabolism:Small molecule interactions:Regulatory functions:Protein fate:Metabolism:Cellular processes and signaling:Information storage and processing:General" 374 "Pseudouridylate synthase:S-adenosylmethionine synthetase:Ribosomal protein S16:Translation initiation factor 3 (IF-3):Ribosomal protein L35:Ribosomal protein L20:GMP synthase, PP-ATPase domain/subunit:Uncharacterized protein conserved in bacteria:Uncharacterized homolog of plant Iojap protein:Septum formation inhibitor:ABC-type multidrug transport system, ATPase component:Predicted membrane GTPase involved in stress response:Predicted metal-binding, possibly nucleic acid-binding protein:Predicted RNA-binding protein containing KH domain, possibly ribosomal protein:Predicted HD superfamily hydrolase involved in NAD metabolism:Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Purine metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Ribosome:General function prediction only:Function unknown:Signal transduction mechanisms:rpmI_bact:S16:hisT_truA:iojap_ybeB:infC:small_GTP:RNA_bind_YhbY:TIGR00488:guaA_Cterm:rplT_bact:metK:minC:Defense mechanisms:Cellular processes and signaling:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Other:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Translation factors:Cellular processes:Cell division:Unknown function:Enzymes of unknown specificity:General:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 375 "" 376 "Thymidylate kinase:DNA polymerase III, alpha subunit:ATP-dependent DNA ligase:Phage-related replication protein:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Replication, recombination and repair:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:Homologous recombination:Non-homologous end-joining:General function prediction only:Function unknown:polc:Metabolism:Poorly characterized:Information storage and processing:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Nucleotide Metabolism" 377 "Ribosomal protein L31:Carbonic anhydrase:ATP-dependent Zn proteases:Cell division protein FtsI/penicillin-binding protein 2:Predicted RNA binding protein (contains ribosomal protein S1 domain):ABC-type multidrug transport system, ATPase and permease components:Predicted membrane protein:Putative stress-responsive transcriptional regulator:Uncharacterized protein conserved in bacteria:Dioxygenases related to 2-nitropropane dioxygenase:Outer membrane lipoprotein-sorting protein:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Predicted membrane protein:Protein required for the initiation of cell division:Uncharacterized conserved protein:Cell cycle control, cell division, chromosome partitioning:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Peptidoglycan biosynthesis:ABC transporters:Ribosome:General function prediction only:Function unknown:Signal transduction mechanisms:L31:TIGR00242:GMP_reduct_2:ftsL_broad:spore_BofA:spore_yabP:spore_yabQ:Defense mechanisms:General:Unknown function:Sporulation and germination:Cell division:Cellular processes:Ribosomal proteins: synthesis and modification:Protein synthesis:Nucleotide and nucleoside interconversions:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Glycan Biosynthesis and Metabolism:Poorly characterized:Nucleotide Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing" 378 "Energy production and conversion:Dihydrofolate reductase:Kef-type K+ transport systems, membrane components:Zn-dependent hydrolases, including glyoxylases:Transcriptional regulator:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Predicted transcriptional regulators:Nitroreductase:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Predicted transcriptional regulators:Predicted phosphohydrolases:Transcriptional regulators:Ketopantoate reductase:Uncharacterized conserved protein:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Arabinose efflux permease:Uncharacterized conserved small protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Inorganic ion transport and metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:apbA_panE:oxido_grp_1:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Pantothenate and coenzyme A:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function:Metabolism:Global:Signal Transduction" 379 "Polyprenyltransferase (cytochrome oxidase assembly factor):Lactoylglutathione lyase and related lyases:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:ATPases with chaperone activity, ATP-binding subunit:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Mannose-6-phosphate isomerase:Small-conductance mechanosensitive channel:Actin-like ATPase involved in cell morphogenesis:DNA-directed RNA polymerase specialized sigma subunit:Micrococcal nuclease (thermonuclease) homologs:Predicted flavoproteins:Predicted membrane protein:Aromatic ring hydroxylase:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Tyrosine metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00275:mreB:cyoE_ctaB:HpaB-1:spore_sigI:Information storage and processing:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Global:Metabolism:Cellular processes:Sporulation and germination:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 380 "" 381 "Energy production and conversion:Uncharacterized conserved protein:Methylated DNA-protein cysteine methyltransferase:Universal stress protein UspA and related nucleotide-binding proteins:Nitroreductase:ABC-type multidrug transport system, ATPase component:Metal-dependent amidase/aminoacylase/carboxypeptidase:Ribosome-associated protein Y (PSrp-1):Predicted transcriptional regulators:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted esterase of the alpha/beta hydrolase fold:Uncharacterized protein conserved in bacteria:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00049:ogt:yfiA:ahpD_dom:amidohydrolases:Defense mechanisms:Translation factors:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:General:Metabolism:Poorly characterized:Information storage and processing:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Cellular processes and signaling:Unknown function:Degradation of proteins, peptides, and glycopeptides:Protein fate" 382 "Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase):Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases:Dihydrodipicolinate reductase:Biotin-(acetyl-CoA carboxylase) ligase:Ketopantoate hydroxymethyltransferase:Panthothenate synthetase:Aspartate/tyrosine/aromatic aminotransferase:Glycosyltransferase:tRNA nucleotidyltransferase/poly(A) polymerase:Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit:Aspartate 1-decarboxylase:DNA-directed RNA polymerase specialized sigma subunit:Flagellar biosynthesis pathway, component FliR:Predicted pyrophosphatase:Methylglyoxal synthase:Uncharacterized proteins, LmbE homologs:Flagellar biogenesis protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Purine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Arginine and proline metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:beta-Alanine metabolism:Pyruvate metabolism:One carbon pool by folate:Pantothenate and CoA biosynthesis:Biotin metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Flagellar assembly:RNA polymerase:General function prediction only:Function unknown:panC:dapB:birA_ligase:gatA:gatC:MGSA:panB:panD:purT:fliR:FliA_WhiG:thiol_BshA:thiol_BshB1:Intracellular trafficking, secretion, and vesicular transport:Glutathione and analogs:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Aspartate family:Amino acid biosynthesis:Chemotaxis and motility:Cellular processes:Protein modification and repair:Protein fate:tRNA aminoacylation:Protein synthesis:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Other:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Translation:Transcription:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Pantothenate and coenzyme A:Carbohydrate Metabolism" 383 "Adenylosuccinate lyase:Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase):Glutamine phosphoribosylpyrophosphate amidotransferase:Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain:Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain:Adenylosuccinate synthase:AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful):Phosphoribosylaminoimidazole (AIR) synthetase:Phosphoribosylamine-glycine ligase:Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase:Folate-dependent phosphoribosylglycinamide formyltransferase PurN:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component:Xanthine/uracil permeases:Nucleotide transport and metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:One carbon pool by folate:Metabolic pathways:Biosynthesis of secondary metabolites:purC:purA:TIGR00302:purH:PurN:ncs2:purD:purM:purB:purF:purK:purE:FGAM_synth_II:FGAM_synth_I:XPRTase:Transport and binding proteins:Salvage of nucleosides and nucleotides:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Metabolism:Nucleotide Metabolism:Nucleosides, purines and pyrimidines" 384 "Energy production and conversion:Acetyl-CoA acetyltransferase:Fe-S oxidoreductase:Heme/copper-type cytochrome/quinol oxidases, subunit 1:Enoyl-CoA hydratase/carnithine racemase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):3-hydroxyacyl-CoA dehydrogenase:Transcriptional regulator:Heme/copper-type cytochrome/quinol oxidases, subunit 2:Heme/copper-type cytochrome/quinol oxidase, subunit 3:Acyl-CoA dehydrogenases:Electron transfer flavoprotein, alpha subunit:Electron transfer flavoprotein, beta subunit:Heme/copper-type cytochrome/quinol oxidase, subunit 4:Predicted membrane protein:Lipid transport and metabolism:Transcription:Fatty acid metabolism:Oxidative phosphorylation:Valine leucine and isoleucine degradation:Geraniol degradation:Benzoate degradation:alpha-Linolenic acid metabolism:Naphthalene degradation:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:AcCoA-C-Actrans:caa3_CtaG:CoxB:CtaD_CoxA:CoxD_Bacillus:Poorly characterized:Metabolism:Information storage and processing:Other:Fatty acid and phospholipid metabolism:Metabolism:Global:Electron transport:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Metabolism:Lipid Metabolism:Energy metabolism:Energy Metabolism" 385 "5-enolpyruvylshikimate-3-phosphate synthase:5-formyltetrahydrofolate cyclo-ligase:Phosphate/sulphate permeases:Biotin-(acetyl-CoA carboxylase) ligase:Aspartate/tyrosine/aromatic aminotransferase:Lipoprotein signal peptidase:Phosphopantetheine adenylyltransferase:Preprotein translocase subunit YidC:N6-adenine-specific methylase:Rad3-related DNA helicases:Deoxynucleoside kinases:Thiamine pyrophosphokinase:Beta-lactamase class C and other penicillin binding proteins:Predicted RNA-binding protein:D-alanyl-D-alanine carboxypeptidase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Peptidoglycan biosynthesis:One carbon pool by folate:Thiamine metabolism:Pantothenate and CoA biosynthesis:Biotin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Protein export:Bacterial secretion system:General function prediction only:Function unknown:lspA:TIGR00095:birA_ligase:cyt_tran_rel:dnaq:aroA:thi_PPkinase:MTHFS_bact:yidC_oxa1_cterm:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:One-carbon metabolism:DNA metabolism:Degradation of DNA:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 386 "Energy production and conversion:Acetylglutamate semialdehyde dehydrogenase:Phosphoglycerate dehydrogenase and related dehydrogenases:Argininosuccinate synthase:Argininosuccinate lyase:Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases:Anaerobic dehydrogenases, typically selenocysteine-containing:Methionine synthase II (cobalamin-independent):Cystathionine beta-lyases/cystathionine gamma-synthases:Methionine synthase I (cobalamin-dependent), methyltransferase domain:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Sugar (pentulose and hexulose) kinases:ABC-type polar amino acid transport system, ATPase component:N-acetylglutamate synthase (N-acetylornithine aminotransferase):Uncharacterized conserved protein, contains double-stranded beta-helix domain:Ribulose 1,5-bisphosphate carboxylase, large subunit:Arabinose efflux permease:Uncharacterized conserved protein, possibly involved in methylthioadenosine recycling:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Arginine and proline metabolism:Selenocompound metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Nitrogen metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Function unknown:Signal transduction mechanisms:argG:ArgJ:argH:2A0118:met_syn_B12ind:HAD-SF-IB:HEQRo_perm_3TM:argC:salvage_mtnB:salvage_mtnW:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Global:Metabolism:Central intermediary metabolism:Sulfur metabolism:Transport and binding proteins:Amino acids, peptides and amines:Carbohydrates, organic alcohols, and acids:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aspartate family:Glutamate family:Cellular processes and signaling:Metabolism:Poorly characterized" 387 "Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Lactoylglutathione lyase and related lyases:Sulfite reductase, alpha subunit (flavoprotein):Predicted permeases:Threonine dehydrogenase and related Zn-dependent dehydrogenases:Arabinose efflux permease:Fucose 4-O-acetylase and related acetyltransferases:Phage-related holin (Lysis protein):Bacteriophage capsid portal protein:Spore coat protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Fatty acid metabolism:Tyrosine metabolism:Tryptophan metabolism:Chloroalkane and chloroalkene degradation:Naphthalene degradation:Aminobenzoate degradation:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:2a69:portal_PBSX:holin_tox_secr:metmalonyl_epim:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Xenobiotics Biodegradation and Metabolism:Global:Metabolism:Transport and binding proteins:Other:Mobile and extrachromosomal element functions:Prophage functions:Cellular processes and signaling:Metabolism:Poorly characterized" 388 "Molecular chaperone:ATPases with chaperone activity, ATP-binding subunit:Molecular chaperone GrpE (heat shock protein):Preprotein translocase subunit SecA (ATPase, RNA helicase):Membrane protein TerC, possibly involved in tellurium resistance:Predicted ATP-dependent serine protease:4-diphosphocytidyl-2-methyl-D-erithritol synthase:Arsenate reductase and related proteins, glutaredoxin family:Transcriptional regulator of heat shock gene:Predicted nucleic-acid-binding protein (contains the HHH domain):Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1:Transcriptional regulator, contains sigma factor-related N-terminal domain:Uncharacterized protein involved in tellurite resistance:Arginine kinase:Uncharacterized protein with conserved CXXC pairs:Transcriptional repressor of class III stress genes:Integral membrane protein (PIN domain superfamily):Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:RNA degradation:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:hrcA:sms:ispD:secA:arsC_related:prok_dnaK:R_switched_YkoY:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Regulatory functions:DNA interactions:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein folding and stabilization:Protein and peptide secretion and trafficking:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 389 "Energy production and conversion:Xaa-Pro aminopeptidase:Glutathione peroxidase:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:ATPase components of ABC transporters with duplicated ATPase domains:Transcriptional regulator:Fe2+/Zn2+ uptake regulation proteins:Predicted transcriptional regulators:Predicted sulfurtransferase:UDP-glucose pyrophosphorylase:Predicted HD superfamily hydrolase:Transcriptional regulators:Predicted transcriptional regulators:Regulator of polyketide synthase expression:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Pentose and glucuronate interconversions:Galactose metabolism:Oxidative phosphorylation:Glutathione metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Arachidonic acid metabolism:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:dhsB:galU:Metabolism:Lipid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:TCA cycle:Energy metabolism:Metabolism:Global:Metabolism of Other Amino Acids" 390 "" 391 "Energy production and conversion:Peptidyl-tRNA hydrolase:Dihydrofolate reductase:Glycosyltransferases involved in cell wall biogenesis:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type multidrug transport system, ATPase and permease components:Transcription-repair coupling factor (superfamily II helicase):NADH dehydrogenase, FAD-containing subunit:Predicted membrane protein:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Arsenate reductase and related proteins, glutaredoxin family:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:DnaK suppressor protein:Ribosomal protein L25 (general stress protein Ctc):Phospholipid-binding protein:Gluconolactonase:Uncharacterized protein containing double-stranded beta helix domain:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose phosphate pathway:Oxidative phosphorylation:Glycerophospholipid metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Ribosome:Nucleotide excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:pth:TIGR00481:mfd:ctc_TL5:yihY_not_rbn:2A0118:arsC_related:Defense mechanisms:Information storage and processing:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Regulatory functions:DNA interactions:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Other:Ribosomal proteins: synthesis and modification:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Unknown function:General:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 392 "Cell wall-associated hydrolases (invasion-associated proteins):Methyl-accepting chemotaxis protein:Flagellar hook-associated protein:Flagellin and related hook-associated proteins:Subtilisin-like serine proteases:Negative regulator of flagellin synthesis (anti-sigma28 factor):Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Two-component system:Bacterial chemotaxis:Flagellar assembly:Signal transduction mechanisms:flgK_ends:flagell_flgL:FlgM_jcvi:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Signal Transduction:Cellular Processes:Cell Motility:Cellular processes:Chemotaxis and motility:Information storage and processing:Environmental Information Processing" 393 "Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA:Transcriptional regulator:Preprotein translocase subunit SecG:Transcriptional regulators:Transcriptional regulators:Fatty acid desaturase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Amino sugar and nucleotide sugar metabolism:Pantothenate and CoA biosynthesis:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Protein export:Bacterial secretion system:secG:ilvE_II:Intracellular trafficking, secretion, and vesicular transport:Amino acid biosynthesis:Carbohydrate Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Protein fate:Protein and peptide secretion and trafficking:Metabolism:Pyruvate family:Information storage and processing:Cellular processes and signaling:Metabolism" 394 "Single-stranded DNA-binding protein:Predicted membrane metal-binding protein:Predicted amidophosphoribosyltransferases:Type II secretory pathway, component PulF:DNA uptake protein and related DNA-binding proteins:Type II secretory pathway, prepilin signal peptidase PulO and related peptidases:Deoxycytidylate deaminase:Type II secretory pathway, pseudopilin PulG:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein):Competence protein:Competence protein ComGC:Signal transduction histidine kinase:Genetic competence transcription factor:Competence protein ComGF:Nucleotide transport and metabolism:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Metabolic pathways:General function prediction only:Signal transduction mechanisms:comF:ComEC_N-term:TIGR00426:ssb:IV_pilin_GFxxxE:ComEB:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Cellular processes and signaling:Information storage and processing:General:Unknown function:DNA transformation:Cellular processes:Protein and peptide secretion and trafficking:Protein fate:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Metabolism:Global:Nucleotide Metabolism:Poorly characterized" 395 "Energy production and conversion:Aspartyl/asparaginyl-tRNA synthetases:Predicted Co/Zn/Cd cation transporters:Ribosomal protein L33:Site-specific DNA methylase:Kef-type K+ transport systems, membrane components:ATPases involved in chromosome partitioning:ABC-type Fe3+-siderophore transport system, permease component:Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily:FOG: CheY-like receiver:ABC-type metal ion transport system, periplasmic component/surface adhesin:Uncharacterized membrane protein:FOG: HEAT repeat:Predicted membrane protein:Response regulator of citrate/malate metabolism:ABC-type Fe3+-citrate transport system, periplasmic component:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:ABC transporters:Two-component system:Bacterial chemotaxis:Ribosome:General function prediction only:Function unknown:Signal transduction mechanisms:asnS:dcm:eps_fam:rpmG_bact:CDF:spore_ypjB:Cations and iron carrying compounds:Amino Acid Metabolism:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Metabolism:Cellular processes:Sporulation and germination:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 396 "Predicted hydrolases of the HAD superfamily:Uncharacterized membrane protein:Squalene cyclase:D-alanyl-D-alanine carboxypeptidase:Zn-dependent proteases:Uncharacterized membrane protein, required for spore maturation in B.subtilis.:Uncharacterized protein conserved in bacteria:Spore germination protein:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Biosynthesis of secondary metabolites:General function prediction only:Function unknown:Cof-subfamily:squalene_cyclas:spore_III_AE:spore_III_AG:spore_III_AB:spore_III_AA:DNA_bind_RsfA:spore_III_AF:Cellular processes and signaling:Metabolism:Cellular processes:Sporulation and germination:Unknown function:Enzymes of unknown specificity:Global:Metabolism:Poorly characterized" 397 "Dimethyladenosine transferase (rRNA methylation):tRNA-dihydrouridine synthase:Trk-type K+ transport systems, membrane components:Predicted S-adenosylmethionine-dependent methyltransferase:Transcription antiterminator:Na+-driven multidrug efflux pump:K+ transport systems, NAD-binding component:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Sulfate permease and related transporters (MFS superfamily):Small-conductance mechanosensitive channel:Uncharacterized membrane protein, putative virulence factor:NAD(FAD)-utilizing enzyme possibly involved in translation:Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase:Small primase-like proteins (Toprim domain):ABC-type polysaccharide/polyol phosphate export systems, permease component:Predicted membrane protein:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:Function unknown:TIGR00091:gid_trmFO:TIGR00147:5S_RNA_mat_M5:ksgA:matE:sulP:nusG:2a38:rSAM_HemZ:Defense mechanisms:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function:Other:Cations and iron carrying compounds:Anions:Transport and binding proteins:tRNA and rRNA base modification:Protein synthesis:RNA processing:Transcription factors:Transcription:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Poorly characterized:Metabolism of Cofactors and Vitamins:Metabolism:Cellular processes and signaling:Information storage and processing" 398 "Energy production and conversion:EMAP domain:Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family:Zn-dependent hydrolases, including glyoxylases:Thioredoxin reductase:Thiol-disulfide isomerase and thioredoxins:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Superoxide dismutase:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Predicted thioesterase:Adenine-specific DNA methylase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Predicted RNA-binding protein homologous to eukaryotic snRNP:Cellulase M and related proteins:Predicted redox protein, regulator of disulfide bond formation:Peroxiredoxin:Predicted metal-sulfur cluster biosynthetic enzyme:Lysophospholipase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted small secreted protein:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:Streptomycin biosynthesis:Inositol phosphate metabolism:Glycerophospholipid metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00051:TRX_reduct:perox_SACOL1771:YtoQ_fam:Information storage and processing:General:Unknown function:Electron transport:Energy metabolism:Metabolism:Global:Biosynthesis of Other Secondary Metabolites:Nucleotide Metabolism:Lipid Metabolism:Metabolism:Carbohydrate Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling" 399 "Energy production and conversion:Isopropylmalate/homocitrate/citramalate synthases:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Acetyl-CoA acetyltransferase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Citrate synthase:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:ABC-type amino acid transport system, permease component:Enoyl-CoA hydratase/carnithine racemase:Predicted ATP-dependent protease:3-hydroxyacyl-CoA dehydrogenase:Lysine 2,3-aminomutase:Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit:Acyl-CoA dehydrogenases:Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit:Acetyl/propionyl-CoA carboxylase, alpha subunit:Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta):Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Fatty acid biosynthesis:Fatty acid metabolism:Synthesis and degradation of ketone bodies:Valine leucine and isoleucine degradation:Geraniol degradation:Lysine degradation:Arginine and proline metabolism:Benzoate degradation:Tryptophan metabolism:beta-Alanine metabolism:Pyruvate metabolism:Naphthalene degradation:Aminobenzoate degradation:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Terpenoid backbone biosynthesis:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:TIGR00238:HEQRo_perm_3TM:DapE-ArgE:AcCoA-C-Actrans:pcaJ_scoB_fam:pcaI_scoA_fam:spore_lonB:GNAT_ablB:Cellular processes and signaling:Metabolism:Degradation of proteins, peptides, and glycopeptides:Protein fate:Other:Fatty acid and phospholipid metabolism:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Transport and binding proteins:Carbohydrate Metabolism:Amino acids, peptides and amines:Cellular processes:Sporulation and germination" 400 "Bacterial nucleoid DNA-binding protein:Uncharacterized phage-encoded protein:Uncharacterized protein conserved in bacteria:Replication, recombination and repair:Function unknown:phage_pRha:Poorly characterized:Information storage and processing:Prophage functions:Mobile and extrachromosomal element functions" 401 "Phage terminase large subunit:Uncharacterized homolog of phage Mu protein gp47:Phage terminase, small subunit:Mu-like prophage tail protein gpP:Bacteriophage capsid portal protein:N-acetylmuramoyl-L-alanine amidase:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:General function prediction only:Function unknown:portal_PBSX:phage_term_2:holin_SPP1:Information storage and processing:Cellular processes and signaling:Poorly characterized:Prophage functions:Mobile and extrachromosomal element functions" 402 "Ribosomal protein L31:UDP-N-acetylglucosamine 2-epimerase:Glycosyltransferases involved in cell wall biogenesis:Thioredoxin reductase:Transcriptional regulator:Predicted transcriptional regulators:Membrane carboxypeptidase (penicillin-binding protein):Putative threonine efflux protein:Transcriptional regulators of sugar metabolism:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Muramidase (flagellum-specific):Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:O-Methyltransferase involved in polyketide biosynthesis:Cell division initiation protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Ribosome:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:mthyl_TIGR00027:L31:wecB:sigma70-ECF:DivI1A_domain:Bthiol_YpdA:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Carbohydrate Metabolism:Genetic Information Processing:Transcription:Translation:Global:Metabolism:Protein synthesis:Ribosomal proteins: synthesis and modification:Unknown function:Enzymes of unknown specificity:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 403 "Uncharacterized conserved protein:Mg2+ and Co2+ transporters:Catalase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Na+/alanine symporter:Hemolysins and related proteins containing CBS domains:Amidases related to nicotinamidase:Uncharacterized conserved protein:Uncharacterized anaerobic dehydrogenase:Predicted glycosyl hydrolase:Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain:Exopolysaccharide biosynthesis protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Tryptophan metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00149_YbjQ:agcS:Fdh-alpha:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Enzymes of unknown specificity:Unknown function:Metabolism:Global:Amino Acid Metabolism:Energy Metabolism:Cellular processes and signaling" 404 "Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:1-acyl-sn-glycerol-3-phosphate acyltransferase:K+ transport systems, NAD-binding component:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Predicted permease:Sulfate permease and related transporters (MFS superfamily):NAD-dependent protein deacetylases, SIR2 family:Peroxiredoxin:Phosphatidylglycerophosphatase A and related proteins:Transcriptional regulators, similar to M. xanthus CarD:Glycerol-3-phosphate responsive antiterminator (mRNA-binding):Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase):Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted metal-dependent enzyme:Predicted transcriptional regulator containing CBS domains:Predicted membrane protein:Response regulator of citrate/malate metabolism:Uncharacterized protein with a bacterial SH3 domain homologue:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:pyro_pdase:AGP_acyltrn:sulP:spore_0_A:Information storage and processing:Sporulation and germination:Cellular processes:Anions:Transport and binding proteins:Degradation of proteins, peptides, and glycopeptides:Protein fate:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism:Carbohydrate Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling" 405 "Energy production and conversion:Anaerobic dehydrogenases, typically selenocysteine-containing:Fe-S oxidoreductase:FAD/FMN-containing dehydrogenases:Zn-dependent alcohol dehydrogenases:Sugar (pentulose and hexulose) kinases:ABC-type antimicrobial peptide transport system, ATPase component:Nitrate reductase beta subunit:NAD(P)H-nitrite reductase:Putative effector of murein hydrolase:Putative effector of murein hydrolase LrgA:Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases:Nitrate reductase delta subunit:Nitrate reductase gamma subunit:Na+/melibiose symporter and related transporters:Nitrate/nitrite transporter:Arabinose efflux permease:Nitrate reductase alpha subunit:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Glyoxylate and dicarboxylate metabolism:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:General function prediction only:narI:glcD:narJ:gph:2A0108:XylB:narG:narH:nitri_red_nirB:nirD_assim_sml:Defense mechanisms:Protein folding and stabilization:Carbohydrate Metabolism:Energy Metabolism:Environmental Information Processing:Signal Transduction:Global:Metabolism:Central intermediary metabolism:Nitrogen metabolism:Energy metabolism:Anaerobic:Other:Sugars:Protein fate:Metabolism:Transport and binding proteins:Anions:Carbohydrates, organic alcohols, and acids:Cellular processes and signaling:Metabolism:Poorly characterized" 406 "Energy production and conversion:Malate/lactate dehydrogenases:Malic enzyme:ABC-type multidrug transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:ABC-type Na+ efflux pump, permease component:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Cytochrome P450:Adenosine deaminase:Fatty acid desaturase:Uncharacterized membrane protein:Phage-related replication protein:Signal transduction histidine kinase:ABC-type uncharacterized transport system, permease component:N-acetylmuramoyl-L-alanine amidase:Nucleotide transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Bisphenol degradation:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Polycyclic aromatic hydrocarbon degradation:Aminobenzoate degradation:Propanoate metabolism:Limonene and pinene degradation:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00294:L-LDH-NAD:Defense mechanisms:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Metabolism:Lipid Metabolism:Conserved:Carbohydrate Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Hypothetical proteins:Glycolysis/gluconeogenesis:Energy metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing" 407 "Energy production and conversion:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Glutamate dehydrogenase/leucine dehydrogenase:Asparagine synthase (glutamine-hydrolyzing):ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Amino acid transporters:NAD-dependent aldehyde dehydrogenases:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Sortase and related acyltransferases:Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific:Beta-glucosidase-related glycosidases:Beta-lactamase class C and other penicillin binding proteins:Thermophilic glucose-6-phosphate isomerase and related metalloenzymes:Uncharacterized protein conserved in bacteria:Arabinose efflux permease:Uncharacterized protein conserved in bacteria:Arginine degradation protein (predicted deacylase):Predicted Zn-dependent protease:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Glyoxylate and dicarboxylate metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Phosphotransferase system (PTS):Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:SP:D1pyr5carbox2:asn_synth_AEB:oligo_HPY:bicupin_oxalic:Defense mechanisms:Metabolism:Cellular processes and signaling:Aspartate family:Amino acid biosynthesis:Carbohydrates, organic alcohols, and acids:Amino acids, peptides and amines:Transport and binding proteins:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Poorly characterized" 408 "" 409 "Energy production and conversion:Pyrroline-5-carboxylate reductase:Glycosyltransferase:Membrane GTPase LepA:Topoisomerase IA:Transcriptional regulator:Organic radical activating enzymes:6-pyruvoyl-tetrahydropterin synthase:UDP-N-acetylmuramyl pentapeptide synthase:Bacterial cell division membrane protein:Enzyme related to GTP cyclohydrolase I:NAD-dependent aldehyde dehydrogenases:ABC-type Mn2+/Zn2+ transport systems, permease components:ABC-type Mn/Zn transport systems, ATPase component:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:Putative effector of murein hydrolase:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:Putative effector of murein hydrolase LrgA:Alcohol dehydrogenase, class IV:Predicted transcriptional regulators:Chromate transport protein ChrA:Membrane protein involved in the export of O-antigen and teichoic acid:Arabinose efflux permease:Transcriptional regulator, effector-binding domain/component:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycine serine and threonine metabolism:Lysine biosynthesis:Arginine and proline metabolism:Peptidoglycan biosynthesis:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:Signal transduction mechanisms:6PTHBS:TIGR00093:proC:small_GTP:TIGR00659:2_A_01_02:topA_bact:murF:BADH:QueF-II:Bsubt_queE:Biosynthesis and degradation of murein sacculus and peptidoglycan:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Cellular processes:Adaptations to atypical conditions:Hypothetical proteins:Conserved:Unknown function:General:Amino acid biosynthesis:Glutamate family:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 410 "" 411 "Energy production and conversion:Molecular chaperone (small heat shock protein):3-oxoacyl-[acyl-carrier-protein] synthase III:Citrate synthase:Isocitrate/isopropylmalate dehydrogenase:Superfamily II DNA/RNA helicases, SNF2 family:Glycerol-3-phosphate dehydrogenase:Glycerophosphoryl diester phosphodiesterase:Membrane proteins related to metalloendopeptidases:Cell division protein FtsI/penicillin-binding protein 2:Uncharacterized conserved protein:Acetyltransferases, including N-acetylases of ribosomal proteins:Alkaline phosphatase:Methylase involved in ubiquinone/menaquinone biosynthesis:Sugar phosphate permease:Predicted membrane protein:Inhibitor of the KinA pathway to sporulation, predicted exonuclease:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Fatty acid biosynthesis:Glycerophospholipid metabolism:Aminobenzoate degradation:Glyoxylate and dicarboxylate metabolism:Butanoate metabolism:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:glpT:fabH:TTC:Transport and binding proteins:Biosynthesis:Fatty acid and phospholipid metabolism:Other:Energy metabolism:Metabolism:Global:Metabolism:Signal Transduction:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Lipid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Other" 412 "Energy production and conversion:Lactoylglutathione lyase and related lyases:Nucleoside-diphosphate-sugar epimerases:Transcriptional regulator:Aldo/keto reductases, related to diketogulonate reductase:Putative intracellular protease/amidase:Nitroreductase:NAD-dependent aldehyde dehydrogenases:Oligoendopeptidase F:Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family:NADH:flavin oxidoreductases, Old Yellow Enzyme family:Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases:Predicted metal-sulfur cluster biosynthetic enzyme:Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides:Penicillin V acylase and related amidases:Uncharacterized conserved protein:Predicted small secreted protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Alanine aspartate and glutamate metabolism:Tyrosine metabolism:Butanoate metabolism:Metabolic pathways:Microbial metabolism in diverse environments:General function prediction only:Function unknown:pepF:PfpI:SSADH:oxido_grp_1:Information storage and processing:Enzymes of unknown specificity:Unknown function:Degradation of proteins, peptides, and glycopeptides:Protein fate:Other:Central intermediary metabolism:Metabolism:Metabolism:Global:Amino Acid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling" 413 ""