Organism : Bacteroides thetaiotaomicron VPI-5482 | Module List :
NP_811296.1 BT_2383

None

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for NP_811296.1
(Mouseover regulator name to see its description)

Warning: No Regulators were found for NP_811296.1!

Warning: NP_811296.1 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
6268 1.20e-09 TAtcTTTGca
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6269 2.40e+03 CAAAaAAg
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6400 1.10e-01 cgaAaactTGCAccgtcgaAAcAa
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6401 3.30e-01 CcCCcccc
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for NP_811296.1

Warning: No Functional annotations were found!

Module neighborhood information for NP_811296.1

NP_811296.1 has total of 57 gene neighbors in modules 273, 344
Gene neighbors (57)
Gene Common Name Description Module membership
NP_809085.1 BT_0172 None 272, 273
NP_809090.1 BT_0177 None 107, 344
NP_809110.1 BT_0197 None 252, 273
NP_809129.1 BT_0216 None 273, 357
NP_809153.1 BT_0240 None 273, 428
NP_809194.1 BT_0281 None 113, 273
NP_809478.1 BT_0565 None 344, 357
NP_809494.1 BT_0581 None 273, 405
NP_809675.1 BT_0762 None 273, 323
NP_809836.1 BT_0923 None 68, 273
NP_809879.1 BT_0966 None 273, 438
NP_809900.1 BT_0987 None 273, 349
NP_809965.1 BT_1052 None 200, 273
NP_810051.1 BT_1138 None 156, 273
NP_810052.1 BT_1139 None 273, 349
NP_810053.1 BT_1140 None 273, 405
NP_810083.1 BT_1170 None 285, 344
NP_810176.1 BT_1263 None 221, 273
NP_810200.1 BT_1287 None 344, 377
NP_810427.1 BT_1514 None 53, 273
NP_810522.1 BT_1609 None 53, 273
NP_810723.1 BT_1810 None 107, 344
NP_810820.1 BT_1907 None 273, 428
NP_810875.1 BT_1962 None 143, 344
NP_810944.1 BT_2031 None 1, 344
NP_811015.1 BT_2102 None 273, 358
NP_811293.1 BT_2380 None 273, 399
NP_811296.1 BT_2383 None 273, 344
NP_811451.1 BT_2538 None 177, 273
NP_811482.1 BT_2569 None 285, 344
NP_811504.1 BT_2591 None 273, 347
NP_811674.1 BT_2762 None 285, 344
NP_811700.1 BT_2788 None 273, 411
NP_811837.1 BT_2925 None 136, 273
NP_812041.1 BT_3129 None 273, 405
NP_812051.1 BT_3139 None 273, 405
NP_812182.1 BT_3270 None 273, 472
NP_812227.1 BT_3315 None 273, 415
NP_812369.1 BT_3457 None 285, 344
NP_812447.1 BT_3535 None 273, 438
NP_812452.1 BT_3540 None 126, 273
NP_812477.1 BT_3565 None 273, 349
NP_812482.1 BT_3570 None 80, 273
NP_812881.1 BT_3970 None 97, 273
NP_812892.1 BT_3981 None 273, 353
NP_812900.1 BT_3989 None 273, 405
NP_812916.1 BT_4005 None 344, 377
NP_813038.1 nagB None 14, 273
NP_813111.1 BT_4200 None 70, 273
NP_813160.1 BT_4249 None 70, 344
NP_813507.1 BT_4596 None 273, 378
NP_813546.1 BT_4635 None 168, 273
NP_813547.1 BT_4636 None 14, 273
NP_813551.1 BT_4640 None 96, 273
NP_813630.1 BT_4719 None 344, 377
NP_813631.1 BT_4720 None 344, 377
NP_813632.1 BT_4721 None 344, 377
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for NP_811296.1
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend