Organism : Bacteroides thetaiotaomicron VPI-5482 | Module List :
NP_812308.1 BT_3396

None

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for NP_812308.1
(Mouseover regulator name to see its description)

Warning: No Regulators were found for NP_812308.1!

Warning: NP_812308.1 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
6414 7.00e-03 Cccc.ggGc.gtgg.g..tCcGtg
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6415 7.90e+02 TtTtTcgTaT.tttG
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6468 3.10e-12 tTTaTtt.TActTTTGc.a
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6469 1.20e+03 cGTATcTTtGc
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for NP_812308.1

Warning: No Functional annotations were found!

Module neighborhood information for NP_812308.1

NP_812308.1 has total of 38 gene neighbors in modules 351, 378
Gene neighbors (38)
Gene Common Name Description Module membership
NP_809101.1 BT_0188 None 6, 378
NP_809424.1 BT_0511 None 215, 378
NP_809481.1 BT_0568 None 322, 378
NP_809590.1 BT_0677 None 371, 378
NP_809730.1 BT_0817 None 215, 378
NP_809803.1 BT_0890 None 117, 378
NP_809809.1 BT_0896 None 96, 378
NP_809865.1 BT_0952 None 96, 378
NP_810146.1 BT_1233 None 208, 378
NP_810147.1 BT_1234 None 68, 378
NP_810423.1 BT_1510 None 326, 351
NP_810683.1 BT_1770 None 141, 378
NP_810752.1 BT_1839 None 299, 378
NP_810801.1 BT_1888 None 117, 378
NP_810943.1 BT_2030 None 1, 351
NP_811079.1 BT_2166 None 197, 351
NP_811331.1 BT_2418 None 104, 378
NP_811404.1 BT_2491 None 351, 446
NP_811405.1 BT_2492 None 351, 446
NP_811582.1 BT_2669 None 371, 378
NP_811590.1 BT_2678 None 207, 351
NP_811693.1 BT_2781 None 104, 378
NP_811738.1 BT_2826 None 378, 429
NP_811909.1 BT_2997 None 177, 351
NP_811910.1 BT_2998 None 177, 351
NP_812308.1 BT_3396 None 351, 378
NP_812309.1 BT_3397 None 197, 351
NP_812945.1 BT_4034 None 197, 351
NP_812946.1 BT_4035 None 197, 351
NP_812947.1 BT_4036 None 197, 351
NP_812968.1 BT_4057 None 147, 351
NP_813102.1 BT_4191 None 136, 378
NP_813107.1 BT_4196 None 219, 351
NP_813413.1 BT_4502 None 197, 351
NP_813480.1 BT_4569 None 197, 351
NP_813481.1 BT_4570 None 197, 351
NP_813482.1 BT_4571 None 197, 351
NP_813507.1 BT_4596 None 273, 378
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for NP_812308.1
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend