Organism : Clostridium acetobutylicum | Module List :
CAC0067

(FS) similar to ABC transporter (permease), YXDM B.subtilis ortholog (NCBI ptt file)

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for CAC0067
(Mouseover regulator name to see its description)

CAC0067 is regulated by 17 influences and regulates 0 modules.
Regulators for CAC0067 (17)
Regulator Module Operator
CAC0465 176 tf
CAC0550 176 tf
CAC0876 176 tf
CAC1333 176 tf
CAC3360 176 tf
CAC3695 176 tf
CAC0299 246 tf
CAC0627 246 tf
CAC0724 246 tf
CAC0766 246 tf
CAC0863 246 tf
CAC1070 246 tf
CAC1333 246 tf
CAC1469 246 tf
CAC1843 246 tf
CAC3214 246 tf
CAC3345 246 tf

Warning: CAC0067 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
7004 1.80e+00 gaggaGAG
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7005 1.40e+03 AAGCcC
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7144 2.50e+00 aaaTtAaagagatAa
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7145 1.60e+03 Ag.agGATG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for CAC0067

Warning: No Functional annotations were found!

Module neighborhood information for CAC0067

CAC0067 has total of 45 gene neighbors in modules 176, 246
Gene neighbors (45)
Gene Common Name Description Module membership
CAC0022 asd Aspartate-semialdehyde dehydrogenase (NCBI ptt file) 176, 231
CAC0050 CAC0050 Hypothetical protein, CF-3 family K28 (NCBI ptt file) 183, 246
CAC0051 CAC0051 Hypothetical protein, CF-3 family (NCBI ptt file) 224, 246
CAC0067 CAC0067 (FS) similar to ABC transporter (permease), YXDM B.subtilis ortholog (NCBI ptt file) 176, 246
CAC0068 CAC0068 (FS) similar to ABC transporter (permease), YXDM B.subtilis ortholog (NCBI ptt file) 40, 246
CAC0130 CAC0130 Uncharacterized membrane protein, YTAF B.subtilis ortholog (NCBI ptt file) 176, 341
CAC0349 CAC0349 Predicted membrane protein (NCBI ptt file) 246, 351
CAC0484 CAC0484 Phosphomannomutase (NCBI ptt file) 40, 246
CAC0550 CAC0550 Possible sigma factor (NCBI ptt file) 176, 253
CAC0652 CAC0652 Uncharacterized conserved membrane protein, similar to MDR (VANZ) ORF of Enterococcus (NCBI ptt file) 246, 353
CAC0691 CAC0691 Uncharacterized conserved protein, VanW of Enterococcus faecalis related (NCBI ptt file) 176, 253
CAC0693 CAC0693 Transcriptional regulator of the LacI family (NCBI ptt file) 176, 238
CAC0777 CAC0777 Acetyltransferase (the isoleucine patch superfamily) (NCBI ptt file) 176, 306
CAC0780 tyrZ Tyrosyl-tRNA synthetase (NCBI ptt file) 246, 306
CAC0816 CAC0816 Lipase-esterase related protein (NCBI ptt file) 176, 209
CAC1045 CAC1045 Predicted permease (NCBI ptt file) 80, 176
CAC1068 CAC1068 Hypothetical protein, CF-25 family (NCBI ptt file) 176, 267
CAC1167 CAC1167 Hypothetical protein (NCBI ptt file) 246, 351
CAC1188 CAC1188 Hypothetical protein (NCBI ptt file) 187, 246
CAC1213 CAC1213 Predicted membrane protein (NCBI ptt file) 246, 351
CAC1215 CAC1215 Hypothetical protein (NCBI ptt file) 4, 176
CAC1312 CAC1312 Hypothetical protein (NCBI ptt file) 109, 176
CAC1397 CAC1397 Predicted hydrolase of PHP superfamily (NCBI ptt file) 246, 306
CAC1400 CAC1400 ABC transporter, periplasmic binding component (NCBI ptt file) 246, 306
CAC1401 CAC1401 ABC transporter, ATPase component (NCBI ptt file) 246, 306
CAC1434 CAC1434 Alkaline phosphatase superfamily protein (NCBI ptt file) 176, 276
CAC1554 CAC1554 Heavy-metal-associated domain (N-terminus) and membrane-bounded cytochrome biogenesis cycZ-like domain, possible membrane copper tolerance protein (NCBI ptt file) 176, 206
CAC1780 CAC1780 Nicotinic acid phosphoribosyltransferase (NCBI ptt file) 246, 306
CAC1782 nadE NH(3)-dependent NAD(+) synthase (nadE) fused to amidohydrolase domain (NCBI ptt file) 246, 306
CAC1920 CAC1920 Zn-finger containing protein (NCBI ptt file) 54, 246
CAC1922 CAC1922 Hypothetical protein (NCBI ptt file) 117, 246
CAC1984 CAC1984 Predicted permease (NCBI ptt file) 176, 183
CAC2051 CAC2051 Predicted membrane protein (NCBI ptt file) 246, 336
CAC2069 CAC2069 Hypothetical protein (NCBI ptt file) 152, 176
CAC2505 CAC2505 Uncharacterized membrane protein, YXJN B.subtilis homolog (NCBI ptt file) 134, 176
CAC2751 CAC2751 Predicted acetyltransferase (NCBI ptt file) 176, 253
CAC2755 CAC2755 MDR-type ABC transporter (membrane associated ATPase) (NCBI ptt file) 140, 176
CAC2756 CAC2756 MDR-type ABC transporter (membrane associated ATPase) (NCBI ptt file) 102, 176
CAC2765 CAC2765 Similar to uncharacterized domain of sensory transducer protein (NCBI ptt file) 176, 309
CAC3360 CAC3360 Transcriptional regulator, LysR family (NCBI ptt file) 176, 277
CAC3386 CAC3386 Hypothetical protein (NCBI ptt file) 132, 176
CAC3404 CAC3404 Uncharactecterized conserved membrane protein, possible ABC-type MDR permease (NCBI ptt file) 246, 351
CAC3414 CAC3414 ABC-type multidrug/protein/lipid transport system, ATPase component (NCBI ptt file) 176, 253
CAC3600 dapA Dihydrodipicolinate synthase (NCBI ptt file) 176, 277
CAC3666 CAC3666 Membrane transporters of cations and cationic drugs (NCBI ptt file) 132, 246
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for CAC0067
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend