Organism : Clostridium acetobutylicum | Module List :
Cobyrinic acid a,c-diamide synthase CobB/CbiA (CBIB protein) (NCBI ptt file)
Functional Annotations (5)
|Cobalamin biosynthesis protein CobD/CbiB||cog/ cog|
|cobalamin biosynthetic process||go/ biological_process|
|integral to membrane||go/ cellular_component|
|adenosylcobinamide-phosphate synthase activity||go/ molecular_function|
Regulation information for CAC0582(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC0582
Module neighborhood information for CAC0582
|Gene||Common Name||Description||Module membership|
|CAC0035||CAC0035||Serine/threonine phosphatase (inactivated protein) (NCBI ptt file)||236, 353|
|CAC0182||CAC0182||Beta-glucosidase homolog (NCBI ptt file)||236, 320|
|CAC0184||CAC0184||Predicted acetyltransferase (NCBI ptt file)||236, 314|
|CAC0191||CAC0191||Transcriptional regulator, RpiR family (NCBI ptt file)||200, 236|
|CAC0202||CAC0202||Hydrolase of the alpha/beta superfamily (NCBI ptt file)||24, 288|
|CAC0203||CAC0203||Flavodoxin (NCBI ptt file)||24, 288|
|CAC0430||CAC0430||Glycerophosphoryl diester phosphodiesterase (NCBI ptt file)||165, 236|
|CAC0582||CAC0582||Cobyrinic acid a,c-diamide synthase CobB/CbiA (CBIB protein) (NCBI ptt file)||236, 288|
|CAC0726||CAC0726||Ribose 5-phosphate isomerase RpiB (NCBI ptt file)||288, 312|
|CAC0786||CAC0786||Uncharacterized conserved protein, repeats (NCBI ptt file)||154, 236|
|CAC0795||CAC0795||Glycosyltransferase involved in cell wall biogenesis (NCBI ptt file)||288, 342|
|CAC0799||psd||Phosphatidylserine decarboxylase (NCBI ptt file)||183, 236|
|CAC1054||CAC1054||Arginase (NCBI ptt file)||165, 236|
|CAC1466||CAC1466||Hypothetical protein (NCBI ptt file)||39, 236|
|CAC1766||CAC1766||Predicted sigma factor (NCBI ptt file)||200, 236|
|CAC2745||CAC2745||Membrane associated methyl-accepting chemotaxis protein (NCBI ptt file)||208, 236|
|CAC2834||CAC2834||Uncharacterized conserved protein, YHAD family (NCBI ptt file)||234, 288|
|CAC2835||gntP||Gluconate permease, gntP (NCBI ptt file)||270, 288|
|CAC2936||CAC2936||Alpha/beta superfamily hydrolase (NCBI ptt file)||236, 360|
|CAC2951||lacC||Tagatose-6-phosphate kinase (NCBI ptt file)||284, 288|
|CAC2952||gatY||Tagatose-bisphosphate aldolase (NCBI ptt file)||284, 288|
|CAC2953||lacB||Galactose-6-phosphate isomerase (NCBI ptt file)||284, 288|
|CAC2954||lacA||Galactose-6-phosphate isomerase (NCBI ptt file)||284, 288|
|CAC2955||lacR||Lactose phosphotransferase system repressor lacR (NCBI ptt file)||288, 342|
|CAC2963||lacG||6-Phospho-Beta-D-Galactosidase (NCBI ptt file)||284, 288|
|CAC2964||lacE||PTS system lactose-specific enzyme IIBC (NCBI ptt file)||288, 342|
|CAC2965||lacF||PTS system lactose-specific enzyme IIA (NCBI ptt file)||284, 288|
|CAC2966||lacR||Lactose phosphotransferase system repressor lacR (NCBI ptt file)||170, 288|
|CAC3343||CAC3343||Biotin synthase related domain containing protein (NCBI ptt file)||9, 236|
|CAC3344||CAC3344||Uncharacterized protein, homolog of hypothetical protein (GI:5918205) from Pseudomonas stutzeri (NCBI ptt file)||165, 236|
|CAC3356||CAC3356||Lactoylglutathione lyase (LGUL) family protein, diverged (NCBI ptt file)||236, 360|
|CAC3495||CAC3495||Multimeric flavodoxin WrbA family protein (NCBI ptt file)||108, 288|
|CAC3507||CAC3507||Transcriptional regulator, MerR family (NCBI ptt file)||236, 265|
|CAC3604||ilvD||Dihydroxyacid dehydratase (NCBI ptt file)||236, 288|
|CAC3605||gntP||High affinity gluconate/L-idonate permease (NCBI ptt file)||236, 288|
|CAC3688||CAC3688||Membrane-associated methyl-accepting chemotaxis protein with HAMP domain (NCBI ptt file)||165, 236|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
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