Module Functions 1 "Energy production and conversion:Glutamate 5-kinase:DNA primase (bacterial type):Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family:Thiol-disulfide isomerase and thioredoxins:Glutamate racemase:ABC-type spermidine/putrescine transport system, permease component II:Predicted membrane protein:Putative transcriptional regulator, homolog of Bvg accessory factor:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Arginine and proline metabolism:D-Glutamine and D-glutamate metabolism:Streptomycin biosynthesis:Inositol phosphate metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Function unknown:glut_race:baf:proB:thioredoxin:dnaG:Biosynthesis and degradation of murein sacculus and peptidoglycan:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Replication and Repair:Global:Metabolism:Energy metabolism:Electron transport:DNA metabolism:DNA replication, recombination, and repair:Amino acid biosynthesis:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 2 "ABC-type Fe3+-siderophore transport system, permease component:ABC-type Fe3+-hydroxamate transport system, periplasmic component:Putative heme iron utilization protein:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:Outer membrane receptor proteins, mostly Fe transport:Choline dehydrogenase and related flavoproteins:Outer membrane receptor for ferrienterochelin and colicins:Amino acid transport and metabolism:Coenzyme transport and metabolism:Inorganic ion transport and metabolism:Pentose phosphate pathway:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism:Carbohydrate Metabolism" 3 "Dihydroorotase:Periplasmic serine proteases (ClpP class):Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Sec-independent protein secretion pathway component TatC:Uncharacterized conserved protein:ABC-type enterochelin transport system, permease component:ABC-type enterochelin transport system, periplasmic component:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Protein export:Bacterial secretion system:Function unknown:hemN:SppA_dom:pyrC_dimer:tatC:Intracellular trafficking, secretion, and vesicular transport:Heme, porphyrin, and cobalamin:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 4 "Ribosomal protein L3:Ribosomal protein L4:Ribosomal protein L23:Ribosomal protein L2:Ribosomal protein L22:Ribosomal protein S3:Ribosomal protein L14:Ribosomal protein L5:Ribosomal protein S8:Ribosomal protein L6P/L9E:Ribosomal protein S5:Ribosomal protein L13:Ribosomal protein S19:Ribosomal protein S17:Ribosomal protein L16/L10E:Ribosomal protein S14:Ribosomal protein L18:Translation, ribosomal structure and biogenesis:Aminoacyl-tRNA biosynthesis:Ribosome:L29:L18_bact:rpsC_bact:rpsE_bact:rplV_bact:rpsS_bact:rplM_bact:rplN_bact:rplP_bact:rplB_bact:L3_bact:S17_bact:L6_bact:rplD_bact:Ribosomal proteins: synthesis and modification:Translation:Protein synthesis:Genetic Information Processing:Information storage and processing" 5 "ATPase components of ABC transporters with duplicated ATPase domains:Signal transduction histidine kinase:Aminoacyl-tRNA biosynthesis:Ribosome:General function prediction only:Signal transduction mechanisms:Poorly characterized:Translation:Cellular processes and signaling:Genetic Information Processing" 6 "Dethiobiotin synthetase:Trk-type K+ transport systems, membrane components:5,10-methylenetetrahydrofolate reductase:Shikimate kinase:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:Predicted phosphohydrolases:Predicted transcriptional regulators:Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB:Predicted metal-dependent hydrolase of the TIM-barrel fold:Predicted glycosyltransferase involved in capsule biosynthesis:Amino acid transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:One carbon pool by folate:Methane metabolism:Carbon fixation pathways in prokaryotes:Biotin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:fadh2:flhB_rel:2a38:Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Transport and binding proteins:Cations and iron carrying compounds:Unknown function:General:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 7 "Adenylosuccinate lyase:Cysteine synthase:Predicted sugar kinase:Superfamily I DNA and RNA helicases:Predicted GTPase:Exonuclease III:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type transport system involved in resistance to organic solvents, permease component:Apolipoprotein N-acyltransferase:Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis):ABC-type long-chain fatty acid transport system, fused permease and ATPase components:ABC-type Fe3+ transport system, permease component:Methylase involved in ubiquinone/menaquinone biosynthesis:Predicted transcriptional regulator:DNA polymerase III, gamma/tau subunits:Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism:Uncharacterized iron-regulated protein:Capsule polysaccharide export protein:ABC-type enterochelin transport system, ATPase component:ABC-type siderophore export system, fused ATPase and permease components:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00056:exoDNase_III:yjeF_cterm:small_GTP:RNAse_H_YqgF:lnt:purB:cysKM:cyc_pep_trnsptr:MenG_MenH_UbiE:dnaX_nterm:Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein modification and repair:Transport and binding proteins:Other:Hypothetical proteins:Conserved:Unknown function:General:Amino acid biosynthesis:Serine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 8 "Energy production and conversion:Anaerobic dehydrogenases, typically selenocysteine-containing:Ribosomal protein L19:Glutamyl-tRNA reductase:Carbamoylphosphate synthase small subunit:Uncharacterized membrane-associated protein:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Predicted endonuclease distantly related to archaeal Holliday junction resolvase:ABC-type metal ion transport system, periplasmic component/surface adhesin:Methyl-accepting chemotaxis protein:Predicted sugar nucleotidyltransferases:Predicted RNA-binding protein (contains KH domain):Anaerobic C4-dicarboxylate transporter:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Bacterial chemotaxis:Ribosome:General function prediction only:Function unknown:Signal transduction mechanisms:bisC_fam:Dcu:rplS_bact:hemA:CPSaseIIsmall:Cellular processes and signaling:Information storage and processing:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Ribosomal proteins: synthesis and modification:Protein synthesis:Pyrimidine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Metabolism:Nucleotide Metabolism:Poorly characterized" 9 "Energy production and conversion:GTPases - translation elongation factors:Ribosomal protein S2:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:Ribosomal protein L17:Co-chaperonin GroES (HSP10):Ribosomal protein L33:Chaperonin GroEL (HSP60 family):Single-stranded DNA-binding protein:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:NifU homolog involved in Fe-S cluster formation:Methyl-accepting chemotaxis protein:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Cytochrome c:Uncharacterized protein conserved in bacteria:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyrimidine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Ribosome:RNA degradation:RNA polymerase:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:L17:sensory_box:small_GTP:ssb:rpsB_bact:rpmJ_bact:rpmG_bact:gyrA:rpoB:GroEL:Information storage and processing:Nucleotide Metabolism:Genetic Information Processing:Transcription:Translation:Folding Sorting and Degradation:Replication and Repair:Global:Metabolism:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Transcription:DNA-dependent RNA polymerase:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein folding and stabilization:Unknown function:General:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 10 "Energy production and conversion:Alanyl-tRNA synthetase:Pentose-5-phosphate-3-epimerase:Diaminopimelate epimerase:Ni,Fe-hydrogenase I large subunit:Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase:CTP synthase (UTP-ammonia lyase):Biotin carboxyl carrier protein:IMP dehydrogenase/GMP reductase:Predicted PP-loop superfamily ATPase:Deoxycytidine deaminase:Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I):ABC-type metal ion transport system, periplasmic component/surface antigen:ATP sulfurylase (sulfate adenylyltransferase):Putative arginyl-tRNA:protein arginylyltransferase:Uncharacterized protein conserved in bacteria:ABC-type tungstate transport system, periplasmic component:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Pentose and glucuronate interconversions:Fatty acid biosynthesis:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Lysine biosynthesis:Selenocompound metabolism:Pyruvate metabolism:Propanoate metabolism:Sulfur metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:hypB:PyrG:alaS:TIGR00364:BCCP:DapF:rpe:IMP_dehydrog:NuoI:dCTP_deam:Aspartate family:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Pentose phosphate pathway:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:2'-Deoxyribonucleotide metabolism:Protein synthesis:tRNA aminoacylation:Protein fate:Protein modification and repair:Unknown function:General:Amino acid biosynthesis:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 11 "Energy production and conversion:Phenylalanyl-tRNA synthetase alpha subunit:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Malate/lactate dehydrogenases:Predicted sugar kinase:Predicted redox protein, regulator of disulfide bond formation:Aspartate/tyrosine/aromatic aminotransferase:Zn-dependent hydrolases, including glyoxylases:Threonine synthase:CDP-diglyceride synthetase:Bacterial nucleoid DNA-binding protein:Acetyl-CoA carboxylase beta subunit:Uncharacterized protein conserved in bacteria:CMP-2-keto-3-deoxyoctulosonic acid synthetase:Phosphatidylglycerophosphatase A and related proteins:Uncharacterized protein (competence- and mitomycin-induced):Tetraacyldisaccharide-1-P 4'-kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Fatty acid biosynthesis:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Lipopolysaccharide biosynthesis:Glycerophospholipid metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Vitamin B6 metabolism:Nicotinate and nicotinamide metabolism:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:acolac_lg:cinA_cterm:thrC:kdsB:pheS:accD:selenium_YedF:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Environmental Information Processing:Carbohydrate Metabolism:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Amino acid biosynthesis:Aspartate family:Pyruvate family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism:Amino Acid Metabolism" 12 "Hydrogenase maturation factor:Excinuclease ATPase subunit:Nuclease subunit of the excinuclease complex:Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family:K+ transport systems, NAD-binding component:Predicted permease:Predicted permeases:S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase):RecG-like helicase:Predicted membrane protein:Predicted permease:High-affinity K+ transport system, ATPase chain B:Cyanate permease:Hemolysin activation/secretion protein:ABC-type enterochelin transport system, permease component:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Streptomycin biosynthesis:Inositol phosphate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Nucleotide excision repair:Homologous recombination:General function prediction only:Function unknown:queA:hypF:uvrC:uvra:ATPase_P-type:adhes_NPXG:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Information storage and processing:Protein modification and repair:Protein fate:tRNA and rRNA base modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Poorly characterized:Carbohydrate Metabolism:Metabolism" 13 "Energy production and conversion:Imidazoleglycerol-phosphate synthase:Thiamine biosynthesis protein ThiC:Acetolactate synthase, small (regulatory) subunit:ATP-dependent Zn proteases:Rhodanese-related sulfurtransferase:Glutathionylspermidine synthase:Methyl-accepting chemotaxis protein:Lactate dehydrogenase and related dehydrogenases:Uncharacterized protein conserved in bacteria:DNA uptake lipoprotein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Valine leucine and isoleucine biosynthesis:Histidine metabolism:Glutathione metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Thiamine metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:acolac_sm:thiC:hisF:Poorly characterized:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Amino acid biosynthesis:Pyruvate family:Histidine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Cellular processes and signaling:Metabolism:Metabolism" 14 "Ribosomal protein L11:Ribosomal protein L1:Ribosomal protein L24:DNA-directed RNA polymerase, alpha subunit/40 kD subunit:Ribosomal protein L27:Ribosomal protein L7/L12:Ribosomal protein L10:Transcription antiterminator:Ribosomal protein L31:Ribosomal protein L21:Ribosomal protein S20:Predicted methyltransferases:Preprotein translocase subunit SecF:Preprotein translocase subunit SecD:Pseudouridylate synthases, 23S RNA-specific:Acetyl-CoA carboxylase alpha subunit:Predicted UDP-glucose 6-dehydrogenase:Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase:Phosphomannomutase:ATP-dependent protease Clp, ATPase subunit:Uncharacterized protein conserved in bacteria:ABC-type tungstate transport system, permease component:Outer membrane protein/protective antigen OMA87:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Pentose and glucuronate interconversions:Fructose and mannose metabolism:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Pyruvate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Ribosome:RNA polymerase:Protein export:Bacterial secretion system:General function prediction only:Function unknown:rluA_subfam:S20:L21:L27:TIGR00096:L31:clpX:accA:L12:2A0604s01:nusG:secE_bact:rpmF_bact:rplX_bact:rplA_bact:L11_bact:lipid_A_lpxA:rpoA:NDP-sugDHase:OM_YaeT:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:Enzymes of unknown specificity:Unknown function:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking:Protein fate:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification:Protein synthesis:Transcription factors:Metabolism:Global:DNA-dependent RNA polymerase:Metabolism:Membrane Transport:Environmental Information Processing:Transcription:Folding Sorting and Degradation:Biosynthesis:Translation:Fatty acid and phospholipid metabolism:Transcription:Genetic Information Processing:Glycan Biosynthesis and Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism" 15 "Energy production and conversion:Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis:Phosphoserine phosphatase:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Thiol:disulfide interchange protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyrimidine metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Mismatch repair:Homologous recombination:Function unknown:TIGR00006:hemN_rel:HAD-SF-IB:Enzymes of unknown specificity:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Global:Metabolism:Unknown function:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cellular processes and signaling:Metabolism:Poorly characterized" 16 "Peroxiredoxin:Thioredoxin reductase:Putative heme iron utilization protein:Catalase:ABC-type Fe3+ transport system, periplasmic component:Uncharacterized protein conserved in bacteria:Outer membrane receptor for ferrienterochelin and colicins:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:Tryptophan metabolism:Methane metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Function unknown:TRX_reduct:Electron transport:Cellular processes and signaling:Metabolism:Poorly characterized:Global:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Amino Acid Metabolism:Nucleotide Metabolism:Metabolism:Energy Metabolism:Metabolism:Energy metabolism" 17 "tRNA-dihydrouridine synthase:3-isopropylmalate dehydratase small subunit:Anthranilate/para-aminobenzoate synthases component I:Predicted GTPase:tRNA delta(2)-isopentenylpyrophosphate transferase:ATP-dependent Zn proteases:Kef-type K+ transport systems, membrane components:DnaJ-class molecular chaperone with C-terminal Zn finger domain:Predicted acid phosphatase:ATPases with chaperone activity, ATP-binding subunit:Predicted phosphatases:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Signal transduction histidine kinase:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:Signal peptidase I:Uncharacterized conserved protein:DnaK suppressor protein:Selenocysteine synthase [seryl-tRNASer selenium transferase]:Osmosensitive K+ channel histidine kinase:Uncharacterized protein conserved in bacteria:Outer membrane lipoprotein-sorting protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Valine leucine and isoleucine biosynthesis:Selenocompound metabolism:Polycyclic aromatic hydrocarbon degradation:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:C5-Branched dibasic acid metabolism:Nicotinate and nicotinamide metabolism:Folate biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Protein export:General function prediction only:Function unknown:Signal transduction mechanisms:surE:leuD:miaA:small_GTP:selA:FtsH_fam:fkbM_fam:HAD-SF-IA-v1:sigpep_I_bact:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Adaptations to atypical conditions:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Pyruvate family:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 18 "Energy production and conversion:Glutamyl- and glutaminyl-tRNA synthetases:Diaminopimelate decarboxylase:Tyrosyl-tRNA synthetase:Thiamine monophosphate synthase:Isocitrate/isopropylmalate dehydrogenase:Leucyl-tRNA synthetase:Predicted GTPase:tmRNA-binding protein:Uracil DNA glycosylase:Uncharacterized membrane protein (homolog of Drosophila rhomboid):Glutathionylspermidine synthase:UDP-N-acetylmuramyl tripeptide synthase:N-acetylmuramoyl-L-alanine amidase:NADH:ubiquinone oxidoreductase subunit 2 (chain N):CMP-N-acetylneuraminic acid synthetase:Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Hemerythrin:Na+/H+ antiporter:Uncharacterized protein conserved in bacteria:Isopenicillin N synthase and related dioxygenases:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Glutathione metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Methane metabolism:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Base excision repair:General function prediction only:Function unknown:smpB:leuB:tyrS:leuS_bact:gltX_bact:ung:thiE:NhaA:lysA:murE:hemeryth_dom:Obg_CgtA:PseF:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Global:Metabolism:Replication and Repair:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Energy Metabolism:Other:Carbohydrate Metabolism:tRNA aminoacylation:Transport and binding proteins:Cations and iron carrying compounds:Amino acid biosynthesis:Aspartate family:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 19 "Methionine aminopeptidase:Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain:Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase:AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful):Molybdenum cofactor biosynthesis enzyme:Phosphopantothenoylcysteine synthetase/decarboxylase:Selenocysteine lyase:Lipoproteins:Inosine-uridine nucleoside N-ribohydrolase:Beta-lactamase class D:DNA polymerase III, gamma/tau subunits:Arabinose efflux permease:Predicted hydrolase of the alpha/beta superfamily:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Purine metabolism:Pyrimidine metabolism:Histidine metabolism:One carbon pool by folate:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:DNA replication:Mismatch repair:Homologous recombination:Sulfur relay system:General function prediction only:Function unknown:TIGR00007:purH:rlpA:met_pdase_I:coaBC_dfp:moaC:FGAM_synth_II:dnaX_nterm:Defense mechanisms:Cellular processes and signaling:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein modification and repair:Amino acid biosynthesis:Histidine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Pantothenate and coenzyme A:Cell envelope:Other:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 20 "Energy production and conversion:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Signal transduction histidine kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Methyl-accepting chemotaxis protein:Polyphosphate kinase:Aspartate ammonia-lyase:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Na+/H+-dicarboxylate symporters:Flagellin and related hook-associated proteins:Succinate dehydrogenase/fumarate reductase, cytochrome b subunit:Heterodisulfide reductase, subunit B:Cbb3-type cytochrome oxidase, cytochrome c subunit:Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit:Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit:Predicted DNA-binding protein with an HTH domain:Amino acid transport and metabolism:Transcription:Cell motility:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Oxidative phosphorylation:Alanine aspartate and glutamate metabolism:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Flagellar assembly:RNA degradation:General function prediction only:Signal transduction mechanisms:dhsB:ccoO:aspA:TAT_signal_seq:cytochr_NrfH:poly_P_kin:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Phosphorus compounds:Energy metabolism:Amino acids and amines:Electron transport:TCA cycle:Protein fate:Protein and peptide secretion and trafficking:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 21 "Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Polyphosphate kinase:Mismatch repair ATPase (MutS family):Coenzyme transport and metabolism:Replication, recombination and repair:Inorganic ion transport and metabolism:Oxidative phosphorylation:Biotin metabolism:Metabolic pathways:RNA degradation:Mismatch repair:bioA:poly_P_kin:Metabolism:Central intermediary metabolism:Phosphorus compounds:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Information storage and processing:Metabolism:Global:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism:Energy Metabolism" 22 "Homoserine kinase:Pseudouridine synthase:Ribonuclease HII:Na+-dependent transporters of the SNF family:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Glycine serine and threonine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:DNA replication:General function prediction only:thrB:TruB:Protein synthesis:Amino Acid Metabolism:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Metabolism:tRNA and rRNA base modification:Amino acid biosynthesis:Aspartate family:Information storage and processing:Metabolism:Poorly characterized" 23 "3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:Homoserine kinase:Transcription elongation factor:Predicted rRNA methylase (SpoU class):Protoheme ferro-lyase (ferrochelatase):Biotin-(acetyl-CoA carboxylase) ligase:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Signal transduction histidine kinase:Exonuclease III:UDP-3-O-acyl-N-acetylglucosamine deacetylase:Predicted sugar phosphate isomerase involved in capsule formation:Periplasmic protein TonB, links inner and outer membranes:Predicted exporters of the RND superfamily:ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains):Flagellar biosynthesis pathway, component FlhA:Nicotinic acid phosphoribosyltransferase:DnaK suppressor protein:Uncharacterized protein conserved in bacteria:G:T/U mismatch-specific DNA glycosylase:Inactivated superfamily I helicase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Glycine serine and threonine metabolism:Lysine biosynthesis:Lipopolysaccharide biosynthesis:Nicotinate and nicotinamide metabolism:Biotin metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Flagellar assembly:Base excision repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:hemH:birA_ligase:TIGR00148:thrB:exoDNase_III:lpxC:kpsF:tonB_Cterm:FlhA:NAPRTase_put:NusA:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Sugars:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein fate:Protein modification and repair:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Chemotaxis and motility:Unknown function:General:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Pyridine nucleotides:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 24 "Prephenate dehydratase:Isopropylmalate/homocitrate/citramalate synthases:Glucose-6-phosphate isomerase:Selenocysteine lyase:Single-stranded DNA-specific exonuclease:Signal transduction histidine kinase:Predicted dehydrogenases and related proteins:Phosphoglyceromutase:Uncharacterized membrane protein (homolog of Drosophila rhomboid):Fucose permease:Predicted permeases:Diacylglycerol kinase:ABC-type metal ion transport system, periplasmic component/surface antigen:Metal-dependent amidase/aminoacylase/carboxypeptidase:Flagellar motor switch protein:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:Predicted glutamine amidotransferases:Sialic acid synthase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Oxidative phosphorylation:Valine leucine and isoleucine biosynthesis:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:Pyruvate metabolism:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Bacterial chemotaxis:Flagellar assembly:Base excision repair:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:taut:recJ:efflux_Bcr_CflA:leuA_bact:pgm_bpd_ind:fliM_switch:CM_P2:amidohydrolases:Information storage and processing:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Other:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Chemotaxis and motility:Amino acid biosynthesis:Aromatic amino acid family:Pyruvate family:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 25 "Dihydroorotate dehydrogenase:Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):Guanosine polyphosphate pyrophosphohydrolases/synthetases:Predicted amidohydrolase:Methionine synthase II (cobalamin-independent):Molybdopterin-guanine dinucleotide biosynthesis protein:Flagellar biosynthesis/type III secretory pathway lipoprotein:Predicted phosphohydrolase (DHH superfamily):Predicted membrane protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell motility:Purine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Tryptophan metabolism:Cyanoamino acid metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Flagellar assembly:Mismatch repair:General function prediction only:Function unknown:Signal transduction mechanisms:efp:mobB:fliF:spoT_relA:pyrD_sub2:met_syn_B12ind:Intracellular trafficking, secretion, and vesicular transport:Molybdopterin:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Replication and Repair:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Protein synthesis:Translation factors:Cellular processes:Adaptations to atypical conditions:Chemotaxis and motility:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 26 "Energy production and conversion:Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Ribosomal protein S15P/S13E:Superfamily I DNA and RNA helicases:NAD-dependent DNA ligase (contains BRCT domain type II):Phosphate/sulphate permeases:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:Uncharacterized membrane-associated protein:Preprotein translocase subunit YidC:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:Bacterial cell division membrane protein:Acetyl-CoA carboxylase alpha subunit:NADH:ubiquinone oxidoreductase subunit 4 (chain M):DnaJ-domain-containing proteins 1:ABC-type antimicrobial peptide transport system, ATPase component:Predicted transcriptional regulators:Uncharacterized conserved protein:DNA segregation ATPase FtsK/SpoIIIE and related proteins:Flagellar biosynthesis pathway, component FliQ:Arabinose efflux permease:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Oxidative phosphorylation:Purine metabolism:Histidine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Pyruvate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Flagellar assembly:Ribosome:DNA replication:Protein export:Bacterial secretion system:Base excision repair:Nucleotide excision repair:Mismatch repair:Sulfur relay system:Function unknown:parB_part:trmU:accA:dnlj:S15_bact:fliQ:FGAM_synth_II:fabZ:NDH_I_M:potass_kdpF:yidC_oxa1_cterm:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Metabolism:Poorly characterized:Electron transport:Energy metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Membrane Transport:Environmental Information Processing:Metabolism:Replication and Repair:Folding Sorting and Degradation:Translation:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Fatty acid and phospholipid metabolism:Carbohydrate Metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Chemotaxis and motility:Information storage and processing:Cellular processes and signaling" 27 "Predicted rRNA methylase (SpoU class):Folylpolyglutamate synthase:Predicted amidohydrolase:tRNA nucleotidyltransferase/poly(A) polymerase:N6-adenine-specific methylase:Type II secretory pathway, component PulD:Outer membrane protein:Multidrug resistance efflux pump:Methylase involved in ubiquinone/menaquinone biosynthesis:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Arginine and proline metabolism:Histidine metabolism:Tyrosine metabolism:Selenocompound metabolism:Polycyclic aromatic hydrocarbon degradation:Folate biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:Bacterial secretion system:General function prediction only:TIGR00740:folC:RND_mfp:pilus_MshL:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Cellular processes and signaling:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transport and binding proteins:Unknown substrate:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Cell envelope:Surface structures:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 28 "Energy production and conversion:Glutamate synthase domain 2:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Fucose permease:NAD-dependent aldehyde dehydrogenases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Sugar phosphate permease:Altronate dehydratase:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Uncharacterized conserved protein:Predicted metal-dependent hydrolase of the TIM-barrel fold:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Pentose and glucuronate interconversions:Fatty acid biosynthesis:Alanine aspartate and glutamate metabolism:Lysine biosynthesis:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Nitrogen metabolism:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:fucP:TIGR02757:Metabolism:Cellular processes and signaling:Conserved:Hypothetical proteins:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Metabolism:Metabolism:Global:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism" 29 "tRNA-dihydrouridine synthase:Dihydroorotate dehydrogenase:ABC-type phosphate transport system, periplasmic component:Zn-dependent hydrolases, including glyoxylases:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:ABC-type phosphate transport system, permease component:Phosphatidylserine decarboxylase:Uncharacterized membrane protein, putative virulence factor:Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Peptidoglycan biosynthesis:Glycerophospholipid metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Two-component system:General function prediction only:Function unknown:PS_decarb:pyrD_sub2:apt:mviN:phosphate_pstC:Information storage and processing:Lipid Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Salvage of nucleosides and nucleotides:Transport and binding proteins:Anions:Unknown function:General:Metabolism:Metabolism:Poorly characterized" 30 "Ribosomal protein S12:Ribosomal protein S7:GTPases - translation elongation factors:Ribosomal protein S10:Ribosomal protein S2:Ribosomal protein L3:Ribosomal protein L4:Ribosomal protein L22:Ribosomal protein L14:Ribosomal protein S8:Ribosomal protein S13:Ribosomal protein S11:Ribosomal protein L13:Ribosomal protein S14:DNA-directed RNA polymerase, alpha subunit/40 kD subunit:Translation elongation factor Ts:Ribosomal protein L33:Ribosomal protein S4 and related proteins:Ribosomal protein L25 (general stress protein Ctc):Translation, ribosomal structure and biogenesis:Transcription:Purine metabolism:Pyrimidine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Ribosome:RNA polymerase:tsf:small_GTP:ctc_TL5:rpsL_bact:rpsB_bact:rpsD_bact:rpmJ_bact:rpmG_bact:rpsG_bact:rplV_bact:rpsJ_bact:rplM_bact:rplN_bact:rpoA:L3_bact:bact_S13:bact_S11:rplD_bact:Information storage and processing:General:Unknown function:Translation factors:Ribosomal proteins: synthesis and modification:Protein synthesis:DNA-dependent RNA polymerase:Transcription:Metabolism:Metabolism:Global:Translation:Transcription:Genetic Information Processing:Nucleotide Metabolism" 31 "Energy production and conversion:Ribosomal protein L28:Translation initiation factor 3 (IF-3):Carbamoylphosphate synthase small subunit:Aspartate 1-decarboxylase:Zn-dependent alcohol dehydrogenases:Flagellar biosynthesis/type III secretory pathway ATPase:Predicted membrane-associated, metal-dependent hydrolase:Cytochrome b subunit of formate dehydrogenase:Putative NADH-flavin reductase:Accessory colonization factor AcfC, contains ABC-type periplasmic domain:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell motility:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:beta-Alanine metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Flagellar assembly:Ribosome:General function prediction only:L28:infC:panD:fliI_yscN:CPSaseIIsmall:formate-DH-gamm:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis of cofactors, prosthetic groups, and carriers:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Electron transport:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Protein synthesis:Ribosomal proteins: synthesis and modification:Translation factors:Metabolism:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 32 "Energy production and conversion:Hydrogenase maturation factor:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Biopolymer transport proteins:ABC-type metal ion transport system, periplasmic component/surface antigen:Predicted membrane protein/domain:Sugar phosphate permease:H+/citrate symporter:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:General function prediction only:Function unknown:hypD:cas_Csn1:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Cellular processes and signaling:Other:Poorly characterized:Protein modification and repair:Protein fate:Mobile and extrachromosomal element functions" 33 "Energy production and conversion:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:tRNA and rRNA cytosine-C5-methylases:2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway):Folylpolyglutamate synthase:Predicted membrane protein:Panthothenate synthetase:ATPase involved in DNA repair:Exoribonuclease R:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:F0F1-type ATP synthase, subunit b:Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Periplasmic protein TonB, links inner and outer membranes:ABC-type long-chain fatty acid transport system, fused permease and ATPase components:Multidrug resistance efflux pump:Acyl-CoA hydrolase:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Heat shock protein:Predicted 3'-5' exonuclease related to the exonuclease domain of PolB:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Histidine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:beta-Alanine metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Pantothenate and CoA biosynthesis:Folate biosynthesis:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:panC:TIGR00023:sensory_box:TIGR00701:hisC:tonB_Cterm:folC:RND_mfp:Defense mechanisms:Poorly characterized:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Folding Sorting and Degradation:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:Transport and binding proteins:Unknown substrate:Cations and iron carrying compounds:Hypothetical proteins:Conserved:Amino acid biosynthesis:Histidine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 34 "Energy production and conversion:Glutamyl- and glutaminyl-tRNA synthetases:Isoleucyl-tRNA synthetase:Histidyl-tRNA synthetase:Methionyl-tRNA synthetase:Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases:Fructose-1,6-bisphosphatase:Histidinol phosphatase and related phosphatases:FAD/FMN-containing dehydrogenases:Phosphoheptose isomerase:Translation initiation factor 1 (IF-1):Nucleoside-diphosphate-sugar epimerases:rRNA methylases:ABC-type branched-chain amino acid transport systems, periplasmic component:Rieske Fe-S protein:RimM protein, required for 16S rRNA processing:Methyl-accepting chemotaxis protein:Cytochrome b subunit of the bc complex:Uncharacterized protein conserved in bacteria:Molybdopterin-guanine dinucleotide biosynthesis protein:Permeases:Cytochrome c1:ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Oxidative phosphorylation:Valine leucine and isoleucine biosynthesis:Selenocompound metabolism:Lipopolysaccharide biosynthesis:Methane metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:infA:cyt_tran_rel:gatA:mobB:rRNA_methyl_3:GmhB_yaeD:GGDEF:ileS:metG:gmhA:hisS:gltX_bact:Rieske_proteo:heptose_epim:16S_RimM:Information storage and processing:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Electron transport:Transcription:RNA processing:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Translation factors:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Signal transduction:Other:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 35 "Energy production and conversion:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:ATPases involved in chromosome partitioning:Predicted Fe-S-cluster oxidoreductase:NAD-dependent aldehyde dehydrogenases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Flagellar GTP-binding protein:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Predicted metal-dependent hydrolase of the TIM-barrel fold:Site-specific recombinase XerD:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Fatty acid biosynthesis:Lysine biosynthesis:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:cas_Csn1:FlhF:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Mobile and extrachromosomal element functions:Chemotaxis and motility:Cellular processes:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism" 36 "Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division:Phosphopantetheine adenylyltransferase:FOG: TPR repeat, SEL1 subfamily:Predicted ATP-dependent serine protease:ABC-type metal ion transport system, ATPase component:Predicted GTPases:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:Predicted phosphoribosyltransferases:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:cyt_tran_rel:gidB:small_GTP:sms:fkbM_fam:Protein synthesis:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Metabolism:tRNA and rRNA base modification:Unknown function:General:Cellular processes and signaling:Metabolism:Poorly characterized" 37 "Glycosyltransferases involved in cell wall biogenesis:Phosphoserine phosphatase:Prolipoprotein diacylglyceryltransferase:Restriction endonuclease S subunits:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase:Uracil-DNA glycosylase:ABC-type Fe3+ transport system, periplasmic component:Inosine-uridine nucleoside N-ribohydrolase:Pyrimidine reductase, riboflavin biosynthesis:Phosphohistidine phosphatase SixA:Na+/serine symporter:ABC-type spermidine/putrescine transport systems, ATPase components:Inactivated superfamily I helicase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Lipopolysaccharide biosynthesis:Riboflavin metabolism:Metabolic pathways:Signal transduction mechanisms:eubact_ribD:lgt:HAD-SF-IB:lipid_A_lpxD:Defense mechanisms:Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Protein fate:Protein modification and repair:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism" 38 "Histidinol phosphatase and related phosphatases:L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D:Phosphoheptose isomerase:Protein-tyrosine-phosphatase:Glycosyltransferase:RecA/RadA recombinase:Anthranilate/para-aminobenzoate synthases component II:Translation initiation factor 2 (IF-2; GTPase):Signal transduction histidine kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Carbon storage regulator (could also regulate swarming and quorum sensing):Methylase involved in ubiquinone/menaquinone biosynthesis:ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase:Uncharacterized small protein:Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Alanine aspartate and glutamate metabolism:Cyanoamino acid metabolism:Lipopolysaccharide biosynthesis:Folate biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Homologous recombination:Function unknown:Signal transduction mechanisms:cyt_tran_rel:csrA:GmhB_yaeD:sensory_box:small_GTP:gmhA:asnASE_II:trpG_papA:TIGR00740:tigrfam_recA:PseG:Cellular processes and signaling:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Amino acids and amines:Regulatory functions:RNA interactions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Unknown function:Enzymes of unknown specificity:General:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 39 "Energy production and conversion:Thymidylate kinase:Fructose-1,6-bisphosphatase:FAD/FMN-containing dehydrogenases:Molybdopterin biosynthesis enzyme:Panthothenate synthetase:Zn-dependent protease with chaperone function:DNA polymerase I - 3'-5' exonuclease and polymerase domains:Putative threonine efflux protein:Uncharacterized protein conserved in bacteria:Predicted membrane protein involved in D-alanine export:Predicted hydrolases of HD superfamily:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Sulfite oxidase and related enzymes:ATP sulfurylase (sulfate adenylyltransferase):Heterodisulfide reductase, subunit B:Flagellar basal body L-ring protein:Multiple antibiotic transporter:Anaerobic C4-dicarboxylate transporter:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein involved in formation of periplasmic nitrate reductase:Predicted periplasmic/secreted protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Pentose phosphate pathway:Fructose and mannose metabolism:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:beta-Alanine metabolism:Selenocompound metabolism:Butanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Pantothenate and CoA biosynthesis:Nitrogen metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Flagellar assembly:DNA replication:Base excision repair:Nucleotide excision repair:Homologous recombination:General function prediction only:Function unknown:panC:DTMP_kinase:pola:Dcu:Intracellular trafficking, secretion, and vesicular transport:DNA metabolism:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 40 "Membrane proteins related to metalloendopeptidases:Periplasmic protein TonB, links inner and outer membranes:Methyl-accepting chemotaxis protein:CMP-N-acetylneuraminic acid synthetase:Acyl-CoA hydrolase:Sulfite oxidase and related enzymes:Uncharacterized iron-regulated protein:Predicted phosphatase:ABC-type spermidine/putrescine transport systems, ATPase components:McrBC 5-methylcytosine restriction system component:Amino acid transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Amino sugar and nucleotide sugar metabolism:Biosynthesis of unsaturated fatty acids:Metabolic pathways:ABC transporters:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:tonB_Cterm:Defense mechanisms:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes and signaling:Metabolism:Poorly characterized" 41 "Energy production and conversion:5-enolpyruvylshikimate-3-phosphate synthase:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:Ribonucleotide reductase, alpha subunit:Type I restriction-modification system methyltransferase subunit:Glycosyltransferases involved in cell wall biogenesis:Organic radical activating enzymes:tRNA nucleotidyltransferase/poly(A) polymerase:Predicted permease:Uncharacterized membrane protein, putative virulence factor:Predicted permeases:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:N-acetylmuramoyl-L-alanine amidase:Exonuclease VII, large subunit:Ni,Fe-hydrogenase I small subunit:Phosphoserine aminotransferase:Uncharacterized protein conserved in bacteria:Dioxygenases related to 2-nitropropane dioxygenase:Holliday junction resolvasome, helicase subunit:ABC-type transport system involved in resistance to organic solvents, auxiliary component:Thiol:disulfide interchange protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Peptidoglycan biosynthesis:One carbon pool by folate:Methane metabolism:Carbon fixation pathways in prokaryotes:Vitamin B6 metabolism:Folate biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Mismatch repair:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00052:xseA:hydA:ruvB:aroA:serC_1:mviN:BioC:NrdE_NrdA:Defense mechanisms:Metabolism:Cellular processes and signaling:Information storage and processing:Biotin:Biosynthesis of cofactors, prosthetic groups, and carriers:Serine family:Aromatic amino acid family:Amino acid biosynthesis:General:Enzymes of unknown specificity:Unknown function:DNA replication, recombination, and repair:Degradation of DNA:DNA metabolism:2'-Deoxyribonucleotide metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Poorly characterized" 42 "Energy production and conversion:Ornithine carbamoyltransferase:Phosphoribosylamine-glycine ligase:Ribosomal protein L7/L12:Co-chaperonin GroES (HSP10):Dihydrodipicolinate reductase:Hydrogenase maturation factor:Hydrogenase maturation factor:Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase:Fe-S-cluster-containing hydrogenase components 1:DnaJ-class molecular chaperone with C-terminal Zn finger domain:Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:NADH:ubiquinone oxidoreductase subunit 6 (chain J):Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Lysyl-tRNA synthetase (class II):ABC-type metal ion transport system, periplasmic component/surface antigen:Flagellar biosynthesis/type III secretory pathway lipoprotein:Uncharacterized enzyme of thiazole biosynthesis:Transthyretin-like protein:Uncharacterized component of anaerobic dehydrogenases:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Oxidative phosphorylation:Purine metabolism:Lysine biosynthesis:Arginine and proline metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Thiamine metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Flagellar assembly:Ribosome:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:dapB:hypB:hypC_hupF:fliF:lysS_bact:ispG_gcpE:orni_carb_tr:L12:purD:TAT_signal_seq:3oxo_ACP_reduc:hypE:DnaJ_bact:thiF_fam2:hdxy_isourate:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Poorly characterized:Metabolism:Global:Cell Motility:Cellular Processes:Metabolism:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Translation:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Other:Purine ribonucleotide biosynthesis:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Cellular processes:Chemotaxis and motility:Amino acid biosynthesis:Aspartate family:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Thiamine:Information storage and processing:Cellular processes and signaling" 43 "Guanylate kinase:Thiamine monophosphate synthase:Signal peptidase I:FOG: CheY-like receiver:Sulfur transfer protein involved in thiamine biosynthesis:Predicted ATP-dependent endonuclease of the OLD family:Acetyl/propionyl-CoA carboxylase, alpha subunit:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Citrate cycle (TCA cycle):Purine metabolism:Pyruvate metabolism:Thiamine metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Protein export:Sulfur relay system:Signal transduction mechanisms:accC:thiS:sigpep_I_bact:guanyl_kin:Intracellular trafficking, secretion, and vesicular transport:Protein and peptide secretion and trafficking:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Protein fate:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism" 44 "Energy production and conversion:Mg-dependent DNase:Dephospho-CoA kinase:Glycosyltransferases involved in cell wall biogenesis:Transcriptional regulator:Thiamine monophosphate kinase:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:N6-adenine-specific methylase:DNA polymerase I - 3'-5' exonuclease and polymerase domains:UDP-N-acetylmuramyl tripeptide synthase:Serine acetyltransferase:Cytochrome bd-type quinol oxidase, subunit 1:Cytochrome bd-type quinol oxidase, subunit 2:Flagellar motor protein:Sugar phosphate permease:Arabinose efflux permease:Selenocysteine-specific translation elongation factor:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Histidine metabolism:Tyrosine metabolism:Selenocompound metabolism:Peptidoglycan biosynthesis:Polycyclic aromatic hydrocarbon degradation:Thiamine metabolism:Pantothenate and CoA biosynthesis:Sulfur metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Bacterial chemotaxis:Flagellar assembly:DNA replication:Base excision repair:Nucleotide excision repair:Homologous recombination:TIGR00010:TIGR00152:cydB:small_GTP:pola:murE:murG:cysE:Cell Motility:Cellular Processes:Replication and Repair:Genetic Information Processing:Metabolism:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Energy metabolism:Electron transport:DNA metabolism:DNA replication, recombination, and repair:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Serine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Global" 45 "Energy production and conversion:Malate/lactate dehydrogenases:Predicted Co/Zn/Cd cation transporters:3-isopropylmalate dehydratase large subunit:Tryptophan synthase beta chain:Methylated DNA-protein cysteine methyltransferase:Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):UDP-N-acetylglucosamine 2-epimerase:Glycosyltransferases involved in cell wall biogenesis:Serine acetyltransferase:ABC-type Mn/Zn transport systems, ATPase component:ABC-type multidrug transport system, ATPase and permease components:Flagellar basal body P-ring biosynthesis protein:Lauroyl/myristoyl acyltransferase:Uncharacterized protein conserved in bacteria:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Lipopolysaccharide biosynthesis:Pyruvate metabolism:Propanoate metabolism:C5-Branched dibasic acid metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:hypA:leuC:trpB:ogt:cysE:CDF:trmA_only:flgA_cterm:NeuC_NnaA:Defense mechanisms:Metabolism:Poorly characterized:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Global:Metabolism:Cell Motility:Cellular Processes:Membrane Transport:Environmental Information Processing:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Energy Metabolism:tRNA and rRNA base modification:Carbohydrate Metabolism:Protein fate:Protein modification and repair:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Chemotaxis and motility:Amino acid biosynthesis:Aromatic amino acid family:Pyruvate family:Serine family:Information storage and processing:Cellular processes and signaling" 46 "Geranylgeranyl pyrophosphate synthase:Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):Type I restriction-modification system methyltransferase subunit:Folate-dependent phosphoribosylglycinamide formyltransferase PurN:Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division:Type I site-specific restriction-modification system, R (restriction) subunit and related helicases:Holliday junction resolvasome, DNA-binding subunit:Na+-dependent transporters of the SNF family:Membrane carboxypeptidase (penicillin-binding protein):Uncharacterized conserved protein:Methyl-accepting chemotaxis protein:Na+/alanine symporter:Oligoendopeptidase F:Lauroyl/myristoyl acyltransferase:Cell shape-determining protein:Cation transport ATPase:Predicted phosphoribosyltransferases:ABC-type enterochelin transport system, permease component:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Purine metabolism:Lipopolysaccharide biosynthesis:One carbon pool by folate:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Bacterial chemotaxis:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:efp:ruvA:gidB:TIGR00278:hsdR:PurN:agcS:ATPase-IB1_Cu:PBP_1a_fam:Defense mechanisms:Poorly characterized:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Restriction/modification:Protein synthesis:tRNA and rRNA base modification:Translation factors:Transport and binding proteins:Cations and iron carrying compounds:Hypothetical proteins:Conserved:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 47 "Dihydroorotase and related cyclic amidohydrolases:Predicted sugar kinase:Superfamily I DNA and RNA helicases:Integral membrane protein possibly involved in chromosome condensation:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:RNase P protein component:Mg2+ and Co2+ transporters:ABC-type branched-chain amino acid transport systems, periplasmic component:Uracil DNA glycosylase:Preprotein translocase subunit YidC:1-deoxy-D-xylulose 5-phosphate reductoisomerase:Uncharacterized conserved protein:Methyl-accepting chemotaxis protein:GTPase:Predicted RNA-binding protein homologous to eukaryotic snRNP:Predicted signal transduction protein:Arabinose efflux permease:Uncharacterized protein, possibly involved in nitrogen fixation:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Pyrimidine metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Ribosome:Protein export:Bacterial secretion system:Base excision repair:Nucleotide excision repair:Mismatch repair:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00052:rnpA:yjeF_cterm:small_GTP:Dxr:TIGR00278:crcB:ung:ccoS:rpmH_bact:yidC_oxa1_cterm:Intracellular trafficking, secretion, and vesicular transport:Conserved:Nucleotide Metabolism:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:RNA processing:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Hypothetical proteins:Metabolism:Unknown function:Enzymes of unknown specificity:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 48 "Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Porphobilinogen deaminase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Aspartate/tyrosine/aromatic aminotransferase:Topoisomerase IA:Predicted dehydrogenases and related proteins:ABC-type polar amino acid transport system, ATPase component:Predicted CoA-binding protein:Flagellar motor switch protein:N-terminal domain of molybdenum-binding protein:Cell division protein:Surface lipoprotein:Uncharacterized protein conserved in bacteria:Predicted ATP-dependent endonuclease of the OLD family:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Glycerophospholipid metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Bacterial chemotaxis:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:hemC:topA_bact:lysidine_TilS_N:fliN:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Metabolism:Membrane Transport:Environmental Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Cellular processes:Lipid Metabolism:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:tRNA and rRNA base modification" 49 "Energy production and conversion:Methionyl-tRNA synthetase:Phosphoribosylaminoimidazole (AIR) synthetase:Glutamine synthetase:FAD/FMN-containing dehydrogenases:3-dehydroquinate synthetase:Polyferredoxin:ATP-dependent Zn proteases:NTP pyrophosphohydrolases including oxidative damage repair enzymes:Small-conductance mechanosensitive channel:Na+-dependent transporters of the SNF family:Membrane proteins related to metalloendopeptidases:Ribosomal protein S21:Pyridoxal phosphate biosynthesis protein:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:GTPase subunit of restriction endonuclease:Tetrahydrodipicolinate N-succinyltransferase:Nitrate reductase cytochrome c-type subunit:Heat shock protein:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Alanine aspartate and glutamate metabolism:Lysine biosynthesis:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Selenocompound metabolism:Glyoxylate and dicarboxylate metabolism:Thiamine metabolism:Vitamin B6 metabolism:Nitrogen metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Ribosome:RNA degradation:General function prediction only:Function unknown:S21p:mauM_napG:metG:pdxJ:GlnA:purM:aroB:napH_:thiH:Defense mechanisms:Metabolism:Global:Signal Transduction:Environmental Information Processing:Folding Sorting and Degradation:Metabolism:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism:Energy metabolism:Electron transport:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Amino acid biosynthesis:Aromatic amino acid family:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridoxine:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 50 "Geranylgeranyl pyrophosphate synthase:Ribonuclease HII:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:Helicase subunit of the DNA excision repair complex:ADP-heptose:LPS heptosyltransferase:Predicted alternative thymidylate synthase:Transcriptional regulator:Homoserine trans-succinylase:AraC-type DNA-binding domain-containing proteins:Uncharacterized protein conserved in bacteria:Uncharacterized small protein:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Lipopolysaccharide biosynthesis:One carbon pool by folate:Terpenoid backbone biosynthesis:Nitrogen metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:DNA replication:Nucleotide excision repair:General function prediction only:Function unknown:uvrb:metA:GOGAT_sm_gam:thyX:heptsyl_trn_II:Cellular processes and signaling:Metabolism:Poorly characterized:Amino acid biosynthesis:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Global:2'-Deoxyribonucleotide metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Replication and Repair:Genetic Information Processing:Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Aspartate family:Energy Metabolism:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing" 51 "Energy production and conversion:Putative translation factor (SUA5):Fe-S oxidoreductase:Guanosine polyphosphate pyrophosphohydrolases/synthetases:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:Thiol-disulfide isomerase and thioredoxins:Signal recognition particle GTPase:ATPase involved in DNA replication initiation:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:RimM protein, required for 16S rRNA processing:Periplasmic protein TonB, links inner and outer membranes:NAD-dependent protein deacetylases, SIR2 family:DNA polymerase III, epsilon subunit and related 3'-5' exonucleases:Transcription termination factor:Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog):Mismatch repair ATPase (MutS family):Co/Zn/Cd efflux system component:Hemolysins and related proteins containing CBS domains:Putative threonine efflux protein:Predicted Rossmann fold nucleotide-binding protein:DNA segregation ATPase FtsK/SpoIIIE and related proteins:Cation transport ATPase:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Predicted ATPase:Hemolysin activation/secretion protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Lysine biosynthesis:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:RNA degradation:DNA replication:Protein export:Bacterial secretion system:Mismatch repair:Homologous recombination:Sulfur relay system:General function prediction only:Signal transduction mechanisms:ftsY:DnaA:dnaq:spoT_relA:TIGR00730:rho:dapE_proteo:CDF:tonB_Cterm:ATPase-IB1_Cu:trmA_only:16S_RimM:tRNA_sel_U_synt:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Replication and Repair:Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Amino Acid Metabolism:Nucleotide Metabolism:DNA replication, recombination, and repair:Carbohydrate Metabolism:Transcription:Transcription factors:RNA processing:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Adaptations to atypical conditions:Hypothetical proteins:Conserved:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Degradation of DNA:DNA metabolism" 52 "Energy production and conversion:Uracil phosphoribosyltransferase:DNA-directed RNA polymerase, beta' subunit/160 kD subunit:Phosphoribosyl-AMP cyclohydrolase:Ribosomal protein S18:N-formylmethionyl-tRNA deformylase:Malic enzyme:Translation elongation factors (GTPases):Lipoprotein signal peptidase:Predicted sugar phosphatases of the HAD superfamily:Phosphatidylserine decarboxylase:NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K):Transcription termination factor:ABC-type Mn2+/Zn2+ transport systems, permease components:Peroxiredoxin:Predicted periplasmic solute-binding protein:Ni,Fe-hydrogenase I small subunit:LuxS protein involved in autoinducer AI2 synthesis:ABC-type metal ion transport system, permease component:Membrane transporters of cations and cationic drugs:Predicted metal-binding protein:Cytochrome c:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Histidine metabolism:Glycerophospholipid metabolism:Pyruvate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Ribosome:RNA polymerase:Protein export:General function prediction only:Signal transduction mechanisms:lspA:pept_deformyl:S18:small_GTP:hydA:upp:HAD-SF-IIA:nusB:rpoC_TIGR:histidine_hisI:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Poorly characterized:Electron transport:Energy metabolism:Metabolism:Global:Signal Transduction:Metabolism:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Translation:Transcription:Genetic Information Processing:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Carbohydrate Metabolism:Salvage of nucleosides and nucleotides:Transcription:DNA-dependent RNA polymerase:Transcription factors:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Histidine family:Information storage and processing:Cellular processes and signaling" 53 "Energy production and conversion:Alanyl-tRNA synthetase:Glycine/serine hydroxymethyltransferase:Leucyl aminopeptidase:Nucleotide-binding protein implicated in inhibition of septum formation:Helicase subunit of the DNA excision repair complex:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):Ni,Fe-hydrogenase maturation factor:Cell division protein FtsI/penicillin-binding protein 2:Cell wall-associated hydrolases (invasion-associated proteins):Nicotinic acid mononucleotide adenylyltransferase:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Na+/H+ antiporter:Predicted periplasmic solute-binding protein:Predicted phosphohydrolase (DHH superfamily):Fibronectin type 3 domain-containing protein:Predicted DNA-binding protein with an HTH domain:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Glycine serine and threonine metabolism:Cyanoamino acid metabolism:Glutathione metabolism:Peptidoglycan biosynthesis:One carbon pool by folate:Methane metabolism:Thiamine metabolism:Nicotinate and nicotinamide metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:RNA polymerase:Nucleotide excision repair:Sulfur relay system:General function prediction only:hydrog_prot:cyt_tran_rel:maf:alaS:uvrb:thiH:thiF_fam2:RpoD_Cterm:Biosynthesis of cofactors, prosthetic groups, and carriers:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein synthesis:tRNA aminoacylation:Cellular processes:Cell division:Metabolism:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 54 "Energy production and conversion:Aspartate-semialdehyde dehydrogenase:Uncharacterized membrane-associated protein:Predicted endonuclease distantly related to archaeal Holliday junction resolvase:NADH:ubiquinone oxidoreductase subunit 6 (chain J):ABC-type Mn2+/Zn2+ transport systems, permease components:Threonine dehydratase:Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase):4-diphosphocytidyl-2-methyl-D-erithritol synthase:Inactive homolog of metal-dependent proteases, putative molecular chaperone:Predicted CoA-binding protein:Predicted permease:Cell division protein:Osmosensitive K+ channel histidine kinase:Arabinose efflux permease:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:RNA degradation:General function prediction only:Function unknown:Signal transduction mechanisms:ispF:ilvA_1Cterm:asd_B:polynuc_phos:Information storage and processing:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyruvate family:Aspartate family:Amino acid biosynthesis:Degradation of RNA:Transcription:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Nucleotide Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Cellular processes and signaling" 55 "Fe2+ transport system protein B:Carbamoylphosphate synthase large subunit (split gene in MJ):DnaJ-class molecular chaperone with C-terminal Zn finger domain:ATPase components of ABC transporters with duplicated ATPase domains:Pseudouridylate synthases, 23S RNA-specific:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type Mn/Zn transport systems, ATPase component:ABC-type multidrug transport system, ATPase and permease components:Uncharacterized conserved protein:ABC-type Fe3+ transport system, periplasmic component:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Metabolic pathways:ABC transporters:General function prediction only:Function unknown:Signal transduction mechanisms:small_GTP:CPSaseII_lrg:DnaJ_bact:Defense mechanisms:Poorly characterized:Nucleotide Metabolism:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 56 "Aspartyl-tRNA synthetase:Protein chain release factor A:Queuine/archaeosine tRNA-ribosyltransferase:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Predicted Zn-dependent peptidases:Small-conductance mechanosensitive channel:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type dipeptide transport system, periplasmic component:Glycyl-tRNA synthetase, alpha subunit:ABC-type amino acid transport system, permease component:Transcription termination factor:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase:Uncharacterized protein conserved in bacteria:Predicted transcriptional regulators:Predicted transcriptional regulator:Carbon starvation protein, predicted membrane protein:Holliday junction resolvasome, helicase subunit:Predicted ATPase (AAA+ superfamily):Predicted ATPase involved in cell division:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Lysine degradation:Biotin metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:ABC transporters:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:prfB:GGDEF:glyQ:Q_tRNA_tgt:aspS_bact:ruvB:rrf2_super:HEQRo_perm_3TM:nusB:TIGR02757:Unknown function:Conserved:Hypothetical proteins:Amino acids, peptides and amines:Transport and binding proteins:Translation factors:tRNA and rRNA base modification:tRNA aminoacylation:Protein synthesis:Transcription factors:Transcription:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Replication and Repair:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Other:Amino Acid Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Signal transduction:General" 57 "Energy production and conversion:Xaa-Pro aminopeptidase:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Uncharacterized protein conserved in bacteria:Uncharacterized protein (competence- and mitomycin-induced):Carbon storage regulator (could also regulate swarming and quorum sensing):Pyridoxal phosphate biosynthesis protein:Cation transport ATPase:Cytochrome b subunit of formate dehydrogenase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Coenzyme transport and metabolism:Inorganic ion transport and metabolism:Polycyclic aromatic hydrocarbon degradation:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Methane metabolism:Vitamin B6 metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:DNA_YbaB_EbfC:cinA_cterm:csrA:ATPase-IB1_Cu:cas2:formate-DH-gamm:Unknown function:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Electron transport:Regulatory functions:RNA interactions:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Cations and iron carrying compounds:Mobile and extrachromosomal element functions:Other:Metabolism:General:Cellular processes and signaling:Metabolism:Poorly characterized" 58 "Phenylalanyl-tRNA synthetase beta subunit:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Methionyl-tRNA formyltransferase:Type I restriction-modification system methyltransferase subunit:K+ transport systems, NAD-binding component:Phosphatidylserine decarboxylase:Selenophosphate synthase:ABC-type amino acid transport system, permease component:S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase):Predicted exporters of the RND superfamily:Predicted transcriptional regulators:ATP-dependent DNA ligase:High-affinity K+ transport system, ATPase chain B:Lysophospholipase L1 and related esterases:Uncharacterized protein conserved in bacteria:Membrane-bound metallopeptidase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Selenocompound metabolism:Glycerophospholipid metabolism:One carbon pool by folate:Biotin metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Two-component system:Base excision repair:Nucleotide excision repair:Mismatch repair:General function prediction only:Function unknown:queA:PS_decarb:fmt:pheT_bact:selD:bioA:ATPase_P-type:HEQRo_perm_3TM:Defense mechanisms:Information storage and processing:Biotin:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino acids, peptides and amines:Transport and binding proteins:tRNA and rRNA base modification:tRNA aminoacylation:Protein synthesis:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Replication and Repair:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Poorly characterized:Lipid Metabolism:Metabolism:Cellular processes and signaling" 59 "Energy production and conversion:Anaerobic dehydrogenases, typically selenocysteine-containing:Valyl-tRNA synthetase:2-methylthioadenine synthetase:Predicted transcriptional regulators:Predicted HD superfamily hydrolase:ABC-type metal ion transport system, periplasmic component/surface antigen:ABC-type metal ion transport system, permease component:Cytochrome P450:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Isopenicillin N synthase and related dioxygenases:Translation, ribosomal structure and biogenesis:Transcription:Inorganic ion transport and metabolism:Valine leucine and isoleucine biosynthesis:Lipopolysaccharide biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00089:HDIG:valS:bisC_fam:autotrns_rpt:Metabolism:Information storage and processing:Pathogenesis:Cellular processes:tRNA aminoacylation:Protein synthesis:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Glycan Biosynthesis and Metabolism:Poorly characterized:Amino Acid Metabolism" 60 "Energy production and conversion:Shikimate 5-dehydrogenase:F0F1-type ATP synthase, gamma subunit:Na+-driven multidrug efflux pump:Phosphoserine phosphatase:Type I site-specific restriction-modification system, R (restriction) subunit and related helicases:Signal transduction histidine kinase:Phosphopantetheine adenylyltransferase:Predicted ATP-dependent serine protease:Phosphatidylserine synthase:Methylase of chemotaxis methyl-accepting proteins:Uracil-DNA glycosylase:Ribosomal protein L11 methylase:Predicted membrane protein:Na+/serine symporter:Predicted glycosyltransferase involved in capsule biosynthesis:Predicted hydrolase (HAD superfamily):Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Glycine serine and threonine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Glycerophospholipid metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:cyt_tran_rel:sensory_box:hsdR:sms:pssA:aroE:matE:ATPsyn_F1gamma:HAD-SF-IB:HAD-SF-IA-v1:Defense mechanisms:Poorly characterized:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:ATP-proton motive force interconversion:Energy Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Restriction/modification:Transport and binding proteins:Other:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aromatic amino acid family:Information storage and processing:Cellular processes and signaling:Metabolism" 61 "Predicted GTPase, probable translation factor:Diaminopimelate decarboxylase:Phosphoribosylamine-glycine ligase:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Hydrogenase maturation factor:NAD/FAD-utilizing enzyme apparently involved in cell division:Biotin synthase and related enzymes:Signal recognition particle GTPase:2-methylthioadenine synthetase:ABC-type branched-chain amino acid transport systems, periplasmic component:UDP-3-O-acyl-N-acetylglucosamine deacetylase:Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase:ABC-type (unclassified) transport system, ATPase component:Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog):Predicted membrane protein/domain:Saccharopine dehydrogenase and related proteins:Flagellar motor switch protein:Accessory colonization factor AcfC, contains ABC-type periplasmic domain:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Lysine biosynthesis:Lysine degradation:Lipopolysaccharide biosynthesis:One carbon pool by folate:Carbon fixation pathways in prokaryotes:Biotin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:Protein export:Bacterial secretion system:General function prediction only:Function unknown:TIGR00089:TIGR00092:gidA:lpxC:bioB:purD:ffh:lysA:lipid_A_lpxA:degP_htrA_DO:hypE:fliN:Intracellular trafficking, secretion, and vesicular transport:Cell envelope:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Chemotaxis and motility:Unknown function:General:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 62 "Adenylosuccinate lyase:3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:Thymidylate kinase:Ribonucleotide reductase, alpha subunit:Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis:Glycosyltransferase:Homoserine dehydrogenase:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):Membrane proteins related to metalloendopeptidases:ABC-type antimicrobial peptide transport system, ATPase component:Threonine dehydratase:Flagellar motor switch protein:Zn-ribbon protein, possibly nucleic acid-binding:Predicted hydrolases of HD superfamily:ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain:Beta-lactamase class D:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Surface lipoprotein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:RNA polymerase:Bacterial secretion system:General function prediction only:TIGR00006:DTMP_kinase:TIGR00148:fliG:purB:ilvA_1Cterm:RpoD_Cterm:NrdE_NrdA:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Biosynthesis and degradation of murein sacculus and peptidoglycan:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Purine ribonucleotide biosynthesis:2'-Deoxyribonucleotide metabolism:Transcription:Transcription factors:Cellular processes:Chemotaxis and motility:Unknown function:General:Amino acid biosynthesis:Pyruvate family:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 63 "Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Chorismate synthase:Phosphoglycerate dehydrogenase and related dehydrogenases:Tryptophanyl-tRNA synthetase:4-hydroxybenzoate polyprenyltransferase and related prenyltransferases:Membrane GTPase LepA:Transcriptional regulator:Thiamine monophosphate kinase:Shikimate kinase:Lipoproteins:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):CMP-N-acetylneuraminic acid synthetase:Predicted glycosyltransferases:Peroxiredoxin:Integral membrane protein CcmA involved in cell shape determination:Sialic acid synthase:Uncharacterized protein conserved in bacteria:O-acetylhomoserine sulfhydrylase:ABC-type uncharacterized transport system, permease component:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Ubiquinone and other terpenoid-quinone biosynthesis:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Tryptophan metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Amino sugar and nucleotide sugar metabolism:Methane metabolism:Thiamine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:aroC:small_GTP:trpS:rlpA:OAH_OAS_sulfhy:PGDH:ubiA_other:NeuB_NnaB:WbuX:Protein synthesis:Metabolism:Metabolism:Global:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Carbohydrate Metabolism:Menaquinone and ubiquinone:Cell envelope:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Serine family:Aromatic amino acid family:Amino acid biosynthesis:General:Unknown function:tRNA aminoacylation" 64 "Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog):Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Kef-type K+ transport systems, membrane components:DnaJ-class molecular chaperone with C-terminal Zn finger domain:Predicted phosphatases:Signal transduction histidine kinase:5,10-methylenetetrahydrofolate reductase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Predicted transcriptional regulators:Uncharacterized enzyme of thiazole biosynthesis:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:Methane metabolism:Carbon fixation pathways in prokaryotes:Thiamine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Signal transduction mechanisms:gatB:fadh2:HAD-SF-IA-v1:degP_htrA_DO:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Protein synthesis:tRNA aminoacylation:Protein fate:Degradation of proteins, peptides, and glycopeptides:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aspartate family:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 65 "Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Prephenate dehydrogenase:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Threonyl-tRNA synthetase:DNA polymerase sliding clamp subunit (PCNA homolog):ATPases involved in chromosome partitioning:Sialic acid synthase:Di- and tripeptidases:Uncharacterized protein related to Endonuclease III:Predicted ATPase (AAA+ superfamily):Uncharacterized protein conserved in bacteria:Collagen-binding surface adhesin SpaP (antigen I/II family):Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Purine metabolism:Pyrimidine metabolism:Arginine and proline metabolism:Histidine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:beta-Alanine metabolism:Glutathione metabolism:Amino sugar and nucleotide sugar metabolism:Thiamine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:HMP-P_kinase:thrS:dnan:gyrB:lp_:PseI:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Global:Carbohydrate Metabolism:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Cell envelope:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Replication and Repair:Translation:Genetic Information Processing:Metabolism" 66 "Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Dihydroorotase:Predicted divalent heavy-metal cations transporter:Prolyl-tRNA synthetase:ATPase involved in DNA repair:Exoribonuclease R:Protease subunit of ATP-dependent Clp proteases:Predicted membrane-associated Zn-dependent proteases 1:Outer membrane receptor proteins, mostly Fe transport:Flagellar hook protein FlgE:ATP-dependent DNA ligase:Hemerythrin:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:Histidine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Flagellar assembly:RNA degradation:Base excision repair:Nucleotide excision repair:Mismatch repair:Function unknown:TIGR00054:sensory_box:proS_fam_II:clpP:pyrC_dimer:hisC:hemeryth_dom:flgE_epsilon:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Regulatory functions:Pyrimidine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Global:Cell Motility:Cellular Processes:Metabolism:Replication and Repair:Folding Sorting and Degradation:Translation:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Amino Acid Metabolism:Small molecule interactions:Nucleotide Metabolism:Protein synthesis:tRNA aminoacylation:Protein fate:Degradation of proteins, peptides, and glycopeptides:Amino acid biosynthesis:Histidine family:Information storage and processing:Cellular processes and signaling:Metabolism" 67 "Diaminopimelate epimerase:Predicted enzyme with a TIM-barrel fold:UDP-N-acetylglucosamine 2-epimerase:Predicted membrane metal-binding protein:Predicted permeases:Non-ribosomal peptide synthetase modules and related proteins:Flagellar hook-associated protein:Disulfide bond formation protein DsbB:Micrococcal nuclease (thermonuclease) homologs:Dihydroneopterin aldolase:Putative NADPH-quinone reductase (modulator of drug activity B):Amino acid transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Lysine biosynthesis:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:TIGR00044:ComEC_N-term:DapF:flgK_ends:NeuC_NnaA:Aspartate family:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Cellular Processes:Cell Motility:Global:Metabolism:Cellular processes:Chemotaxis and motility:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 68 "Energy production and conversion:Uncharacterized conserved protein:FAD/FMN-containing dehydrogenases:Membrane proteins related to metalloendopeptidases:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:UDP-N-acetylglucosamine enolpyruvyl transferase:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Arginine decarboxylase (spermidine biosynthesis):DNA-directed RNA polymerase specialized sigma subunit:Flagellin and related hook-associated proteins:Predicted alternative thymidylate synthase:Uncharacterized conserved protein:Cell shape-determining protein:Tetrahydrodipicolinate N-succinyltransferase:Cation transport ATPase:Putative NADH-flavin reductase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Pyrimidine metabolism:Lysine biosynthesis:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Flagellar assembly:RNA polymerase:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00423:TIGR01033:murA:speA:ATPase-IB1_Cu:thyX:FliA_WhiG:Cellular processes and signaling:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Polyamine biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:Regulatory functions:DNA interactions:Transport and binding proteins:Cations and iron carrying compounds:Hypothetical proteins:Conserved:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 69 "Energy production and conversion:5-enolpyruvylshikimate-3-phosphate synthase:Geranylgeranyl pyrophosphate synthase:Cysteinyl-tRNA synthetase:Dihydrodipicolinate reductase:Aspartokinases:Uncharacterized membrane-associated protein:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:FOG: Ankyrin repeat:Thioredoxin-like proteins and domains:Penicillin tolerance protein:NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G):Predicted Na+/dicarboxylate symporter:Predicted ATPase involved in cell division:Peptidylarginine deiminase and related enzymes:Pyruvate/oxaloacetate carboxyltransferase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Oxidative phosphorylation:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Pyruvate metabolism:Porphyrin and chlorophyll metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:dapB:ispH_lytB:cysS:hemN_rel:asp_kin_monofn:aroA:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein synthesis:tRNA aminoacylation:Amino acid biosynthesis:Aromatic amino acid family:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 70 "Putative translation factor (SUA5):Predicted GTPase, probable translation factor:Transketolase:3-isopropylmalate dehydratase small subunit:Recombinational DNA repair protein (RecF pathway):NAD/FAD-utilizing enzyme apparently involved in cell division:Glycosyltransferases involved in cell wall biogenesis:Na+-driven multidrug efflux pump:Predicted Fe-S-cluster redox enzyme:Na+/H+ antiporter NhaD and related arsenite permeases:Deoxyxylulose-5-phosphate synthase:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1:Predicted phosphohydrolases:Methylase involved in ubiquinone/menaquinone biosynthesis:Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB:Lysophospholipase L1 and related esterases:Predicted metal-dependent hydrolase of the TIM-barrel fold:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose phosphate pathway:Ubiquinone and other terpenoid-quinone biosynthesis:Valine leucine and isoleucine biosynthesis:C5-Branched dibasic acid metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Homologous recombination:General function prediction only:Function unknown:TIGR00048:TIGR00092:gidA:leuD:dxs:tktlase_bact:recR:flhB_rel:matE:MenG_MenH_UbiE:Defense mechanisms:Unknown function:Other:Transport and binding proteins:tRNA and rRNA base modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Pentose phosphate pathway:Energy metabolism:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Amino acid biosynthesis:Carbohydrate Metabolism:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:General" 71 "3-polyprenyl-4-hydroxybenzoate decarboxylase:Pyrroline-5-carboxylate reductase:Aspartate carbamoyltransferase, catalytic chain:Glycine/D-amino acid oxidases (deaminating):ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Predicted rRNA methylase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Function unknown:proC:ubiX_pad:asp_carb_tr:MnmC_Cterm:Enzymes of unknown specificity:Amino acid biosynthesis:Glutamate family:Information storage and processing:Metabolism:Poorly characterized:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide Metabolism:Pyrimidine ribonucleotide biosynthesis:Protein synthesis:tRNA and rRNA base modification:Unknown function" 72 "Energy production and conversion:Xaa-Pro aminopeptidase:Hydrogenase maturation factor:3-polyprenyl-4-hydroxybenzoate decarboxylase:Trk-type K+ transport systems, membrane components:Conserved domain frequently associated with peptide methionine sulfoxide reductase:Pyrroline-5-carboxylate reductase:Nitroreductase:Formyltetrahydrofolate hydrolase:ADP-heptose:LPS heptosyltransferase:Predicted rRNA methylase:DNA polymerase III, delta subunit:Uncharacterized conserved protein:Aminoglycoside N3'-acetyltransferase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Pyrimidine metabolism:Arginine and proline metabolism:Lipopolysaccharide biosynthesis:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Mismatch repair:Homologous recombination:Function unknown:proC:hypF:TIGR00357:ubiX_pad:PurU:2a38:heptsyl_trn_II:Defense mechanisms:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein fate:Protein modification and repair:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Adaptations to atypical conditions:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Glutamate family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 73 "Molecular chaperone:ATPases with chaperone activity, ATP-binding subunit:Molecular chaperone GrpE (heat shock protein):Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Transcriptional regulator of heat shock gene:Choline dehydrogenase and related flavoproteins:Amino acid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Pentose phosphate pathway:Thiamine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:RNA degradation:Sulfur relay system:prok_dnaK:nifS_epsilon:Protein folding and stabilization:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Protein fate:Carbohydrate Metabolism" 74 "Energy production and conversion:Succinyl-CoA synthetase, alpha subunit:Nucleoside diphosphate kinase:Acyl carrier protein:Ni,Fe-hydrogenase I large subunit:IMP dehydrogenase/GMP reductase:FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor):DNA polymerase sliding clamp subunit (PCNA homolog):Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Amino acid permeases:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Phosphomannomutase:Flagellar motor component:L-serine deaminase:Ni,Fe-hydrogenase I cytochrome b subunit:Cytochrome c, mono- and diheme variants:FOG: PAS/PAC domain:Monomeric isocitrate dehydrogenase:Predicted membrane protein:Cbb3-type cytochrome oxidase, subunit 1:Fibronectin type 3 domain-containing protein:Short-chain alcohol dehydrogenase of unknown specificity:Cbb3-type cytochrome oxidase, subunit 3:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Glutathione metabolism:Amino sugar and nucleotide sugar metabolism:Propanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Flagellar assembly:DNA replication:Mismatch repair:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:tig:monomer_idh:sensory_box:acyl_carrier:dnan:sda_mono:ccoN:sucCoAalpha:IMP_dehydrog:glmM:sdhA_frdA_Gneg:CytB-hydogenase:cbb3_Q_epsi:Protein folding and stabilization:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Amino sugars:Energy metabolism:Electron transport:Glycolysis/gluconeogenesis:TCA cycle:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 75 "Energy production and conversion:Carbonic anhydrase:Polyferredoxin:Biotin carboxyl carrier protein:Restriction endonuclease S subunits:3-dehydroquinate dehydratase II:UDP-N-acetylmuramate-alanine ligase:Ribosomal protein S21:Chemotaxis signal transduction protein:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Predicted membrane protein:Amino acid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Fatty acid biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:D-Glutamine and D-glutamate metabolism:Peptidoglycan biosynthesis:Pyruvate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Flagellar assembly:Ribosome:Function unknown:Signal transduction mechanisms:S21p:BCCP:murC:aroQ:ccoG_rdxA_fixG:Defense mechanisms:Cell envelope:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Protein synthesis:Ribosomal proteins: synthesis and modification:Amino acid biosynthesis:Aromatic amino acid family:Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 76 "Transcription elongation factor:UDP-N-acetylmuramoylalanine-D-glutamate ligase:Actin-like ATPase involved in cell morphogenesis:Uncharacterized conserved protein:Predicted metal-dependent hydrolase:Arabinose efflux permease:Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen:Uncharacterized protein conserved in bacteria:Adenine-specific DNA methylase:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:D-Glutamine and D-glutamate metabolism:Peptidoglycan biosynthesis:Metabolic pathways:General function prediction only:Function unknown:mreB:murD:NusA:Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Global:Metabolism:Transcription:Transcription factors:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 77 "Protein chain release factor A:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:ATP-dependent Zn proteases:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:Phosphoserine phosphatase:Predicted membrane metal-binding protein:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):DnaJ-domain-containing proteins 1:Predicted membrane protein:Predicted periplasmic solute-binding protein:Aspartate racemase:Uncharacterized conserved protein:Cyclopropane fatty acid synthase and related methyltransferases:Predicted membrane protein:Arabinose efflux permease:Outer membrane lipoprotein-sorting protein:Capsule polysaccharide export protein:ABC-type transport system, involved in lipoprotein release, permease component:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycine serine and threonine metabolism:Peptidoglycan biosynthesis:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:prfA:asp_race:TIGR00247:serB:ComEC_N-term:mraY:yihY_not_rbn:Ac_CoA_lig_AcsA:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Amino acids and amines:Protein synthesis:Translation factors:Hypothetical proteins:Conserved:Unknown function:General:Amino acid biosynthesis:Serine family:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 78 "ABC-type phosphate transport system, periplasmic component:Thioredoxin reductase:ABC-type phosphate transport system, permease component:DNA-binding ferritin-like protein (oxidative damage protectant):Na+/alanine symporter:ABC-type phosphate transport system, ATPase component:Hemolysins and related proteins containing CBS domains:Uncharacterized protein conserved in bacteria:Sugar phosphate permease:Hemerythrin:Arabinose efflux permease:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:ABC transporters:Two-component system:General function prediction only:Function unknown:agcS:3a0107s01c2:phosphate_pstC:hemeryth_dom:Membrane Transport:Environmental Information Processing:Metabolism:Cellular processes and signaling:Anions:Transport and binding proteins:Signal Transduction:Poorly characterized" 79 "Peptide methionine sulfoxide reductase:Ribonuclease HI:Biotin synthase and related enzymes:DNA polymerase III, delta subunit:4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase:Hemerythrin:Uncharacterized protein conserved in bacteria:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Biotin metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Mismatch repair:Homologous recombination:Function unknown:ispE:msrA:bioB:BioC:hemeryth_dom:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Adaptations to atypical conditions:Metabolism:Global:Cellular processes:Metabolism:Replication and Repair:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Other:Nucleotide Metabolism:Biotin" 80 "Glutamate-1-semialdehyde aminotransferase:Molybdopterin biosynthesis enzyme:Carbamoylphosphate synthase large subunit (split gene in MJ):rRNA methylases:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Selenophosphate synthase:ABC-type polar amino acid transport system, ATPase component:ATPase related to the helicase subunit of the Holliday junction resolvase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Selenocompound metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:rRNA_methyl_3:selD:hemL:CPSaseII_lrg:tRNA and rRNA base modification:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Protein synthesis:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Metabolism:Poorly characterized" 81 "Energy production and conversion:NAD synthase:Orotidine-5'-phosphate decarboxylase:Molybdenum cofactor biosynthesis enzyme:Protein-tyrosine-phosphatase:Predicted GTPase:Threonine synthase:UDP-galactopyranose mutase:Na+-dependent transporters of the SNF family:ABC-type amino acid transport system, permease component:Predicted amidophosphoribosyltransferases:Lactate dehydrogenase and related dehydrogenases:FOG: LysM repeat:Integral membrane protein CcmA involved in cell shape determination:Sec-independent protein secretion pathway components:4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase:Sulfite oxidase and related enzymes:Phosphohistidine phosphatase SixA:Uncharacterized protein conserved in bacteria:Uncharacterized FlgJ-related protein:Selenocysteine-specific translation elongation factor:Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Pyrimidine metabolism:Glycine serine and threonine metabolism:Vitamin B6 metabolism:Nicotinate and nicotinamide metabolism:Terpenoid backbone biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Protein export:Bacterial secretion system:Sulfur relay system:General function prediction only:Function unknown:Signal transduction mechanisms:UDP-GALP_mutase:ispE:small_GTP:thrC:nadE:moaC:tatB:HEQRo_perm_3TM:pyrF:PseG:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Amino acids, peptides and amines:Unknown function:General:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Molybdopterin:Pyridine nucleotides:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 82 "Energy production and conversion:Riboflavin synthase beta-chain:Glycine/serine hydroxymethyltransferase:Biotin carboxylase:NTP pyrophosphohydrolases including oxidative damage repair enzymes:FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor):Predicted phosphatases:Chemotaxis protein histidine kinase and related kinases:F0F1-type ATP synthase, subunit b:Rieske Fe-S protein:Chemotaxis signal transduction protein:Uncharacterized membrane protein, required for colicin V production:Cytochrome b subunit of the bc complex:Flagellar capping protein:Rubrerythrin:Predicted periplasmic solute-binding protein:Predicted membrane protein:Cytochrome c1:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Fatty acid biosynthesis:Oxidative phosphorylation:Glycine serine and threonine metabolism:Cyanoamino acid metabolism:Pyruvate metabolism:Propanoate metabolism:One carbon pool by folate:Methane metabolism:Carbon fixation pathways in prokaryotes:Riboflavin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Flagellar assembly:RNA degradation:General function prediction only:Function unknown:Signal transduction mechanisms:lumazine-synth:tig:desulf_FeS4:accC:Rieske_proteo:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Electron transport:Fatty acid and phospholipid metabolism:Biosynthesis:Protein fate:Protein folding and stabilization:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 83 "Energy production and conversion:Arginyl-tRNA synthetase:Glutamine phosphoribosylpyrophosphate amidotransferase:ATP phosphoribosyltransferase:Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Ribosomal protein S12:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Histidinol dehydrogenase:Glucose-6-phosphate isomerase:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:Fructose/tagatose bisphosphate aldolase:Guanylate kinase:Ribosomal protein L27:Ribosome recycling factor:Malic enzyme:3-oxoacyl-(acyl-carrier-protein) synthase:Ribosomal protein S6:Fe2+/Zn2+ uptake regulation proteins:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Parvulin-like peptidyl-prolyl isomerase:Predicted transcriptional regulators:Cation/multidrug efflux pump:Ribosome-binding factor A:Membrane protein TerC, possibly involved in tellurium resistance:Uncharacterized membrane protein, required for colicin V production:Predicted membrane protein/domain:Dioxygenases related to 2-nitropropane dioxygenase:Putative NADPH-quinone reductase (modulator of drug activity B):O-acetylhomoserine sulfhydrylase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Fatty acid biosynthesis:Purine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Histidine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Nitrogen metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Ribosome:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:L27:hisD:hisG:rbfA:S6:cbbA:argS:frr:2A0602:rpsL_bact:gyrA:ilvE_I:purF:purE:OAH_OAS_sulfhy:fabF:guanyl_kin:Defense mechanisms:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Purine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Transcription:RNA processing:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Translation factors:Transport and binding proteins:Unknown substrate:Amino acid biosynthesis:Pyruvate family:Serine family:Histidine family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 84 "Energy production and conversion:Dihydroxyacid dehydratase/phosphogluconate dehydratase:Phosphoribosyl-AMP cyclohydrolase:Thiol-disulfide isomerase and thioredoxins:Flavodoxins:FKBP-type peptidyl-prolyl cis-trans isomerases 2:Uncharacterized protein conserved in bacteria:Capsule polysaccharide export protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Valine leucine and isoleucine biosynthesis:Histidine metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Function unknown:ilvD:thioredoxin:flav_long:histidine_hisI:Amino acid biosynthesis:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Metabolism:Pyruvate family:Histidine family:Cellular processes and signaling:Metabolism:Poorly characterized" 85 "Energy production and conversion:Thioredoxin reductase:Hemoglobin-like flavoprotein:ABC-type Fe3+ transport system, periplasmic component:Uncharacterized protein conserved in bacteria:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:Aminoacyl-tRNA biosynthesis:ABC transporters:Two-component system:Function unknown:TRX_reduct:Energy metabolism:Nucleotide Metabolism:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Signal Transduction:Metabolism:Electron transport:Cellular processes and signaling:Metabolism:Poorly characterized" 86 "Energy production and conversion:Argininosuccinate synthase:Argininosuccinate lyase:Phosphotransacetylase:Acetate kinase:Predicted membrane protein:Mg2+ and Co2+ transporters:Membrane-fusion protein:UDP-glucose pyrophosphorylase:Flagellar hook-associated protein:Flagellin and related hook-associated proteins:Uncharacterized conserved protein:Flagellar hook-basal body protein:Flagellar basal-body P-ring protein:Flagellar basal body protein:Flagellar hook capping protein:Flagellar basal body L-ring protein:Anaerobic C4-dicarboxylate transporter:Uncharacterized protein conserved in bacteria:Flagellar basal body rod protein:Amino acid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Galactose metabolism:Oxidative phosphorylation:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Taurine and hypotaurine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Flagellar assembly:General function prediction only:Function unknown:ackA:TIGR00023:argG:fliE:corA:pta:Dcu:argH:galU:FlgB:RND_mfp:flgG_G_neg:flgK_ends:FlgEFG_subfam:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Global:Cell Motility:Cellular Processes:Metabolism:Signal Transduction:Environmental Information Processing:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Energy metabolism:Fermentation:Fatty acid and phospholipid metabolism:Biosynthesis:Transport and binding proteins:Unknown substrate:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Cellular processes:Chemotaxis and motility:Amino acid biosynthesis:Glutamate family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Poorly characterized" 87 "Energy production and conversion:Inorganic pyrophosphatase:Anaerobic dehydrogenases, typically selenocysteine-containing:Polyferredoxin:Citrate synthase:Biotin carboxylase:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Predicted dehydrogenase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Aspartate ammonia-lyase:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Ferredoxin:Cytochrome c peroxidase:Cytochrome c, mono- and diheme variants:Uncharacterized protein conserved in bacteria:Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit:Nitrate reductase cytochrome c-type subunit:Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit:Cbb3-type cytochrome oxidase, subunit 3:Amino acid transport and metabolism:Lipid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Fatty acid biosynthesis:Oxidative phosphorylation:Alanine aspartate and glutamate metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:dhsB:TIGR00426:accC:aspA:TAT_signal_seq:cit_synth_I:cbb3_Q_epsi:ccoG_rdxA_fixG:cytochr_NrfH:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Global:Metabolism:Energy metabolism:Amino acids and amines:Electron transport:TCA cycle:Fatty acid and phospholipid metabolism:Biosynthesis:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:DNA transformation:Cellular processes and signaling:Metabolism:Metabolism" 88 "Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Phosphoribosylanthranilate isomerase:Dihydropteroate synthase and related enzymes:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Valyl-tRNA synthetase:Membrane carboxypeptidase (penicillin-binding protein):Methyl-accepting chemotaxis protein:CMP-N-acetylneuraminic acid synthetase:ABC-type polar amino acid transport system, ATPase component:ABC-type transport system involved in resistance to organic solvents, ATPase component:Transcription-repair coupling factor (superfamily II helicase):Metal-dependent amidase/aminoacylase/carboxypeptidase:Outer membrane protein:Periplasmic protein involved in polysaccharide export:Predicted signal transduction protein:Type II secretory pathway, pseudopilin PulG:ABC-type transport system involved in resistance to organic solvents, auxiliary component:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Valine leucine and isoleucine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Amino sugar and nucleotide sugar metabolism:Folate biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Bacterial secretion system:Nucleotide excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:valS:DHPS:amidohydrolases:PBP_1a_fam:IV_pilin_GFxxxE:PseF:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope:Folic acid:Biosynthesis of cofactors, prosthetic groups, and carriers:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking:Protein fate:tRNA aminoacylation:Protein synthesis:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Replication and Repair:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism" 89 "Prephenate dehydratase:Pseudouridylate synthase:Anthranilate/para-aminobenzoate synthases component I:Predicted EndoIII-related endonuclease:Replicative DNA helicase:Predicted enzyme with a TIM-barrel fold:3-dehydroquinate synthetase:ATP-dependent Zn proteases:ATPase involved in DNA replication initiation:2-methylthioadenine synthetase:Small-conductance mechanosensitive channel:Cell division protein FtsI/penicillin-binding protein 2:Enzyme related to GTP cyclohydrolase I:Oligoendopeptidase F:Arginine decarboxylase (spermidine biosynthesis):Disulfide bond formation protein DsbB:DNA/RNA endonuclease G, NUC1:Homoserine trans-succinylase:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Predicted membrane protein:Molybdenum cofactor biosynthesis enzyme:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Cysteine and methionine metabolism:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Peptidoglycan biosynthesis:Folate biosynthesis:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:DNA replication:Base excision repair:Sulfur relay system:General function prediction only:Function unknown:TIGR00044:hisT_truA:TIGR00089:DnaA:DnaB:metA:nth:speA:aroB:CM_P2:moaA:QueF-II:Poorly characterized:Energy Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:Central intermediary metabolism:Polyamine biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aromatic amino acid family:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 90 "Energy production and conversion:DNA-directed RNA polymerase, beta' subunit/160 kD subunit:Dihydroxyacid dehydratase/phosphogluconate dehydratase:Prephenate dehydrogenase:Thioredoxin reductase:Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily:Putative transcription activator:Uncharacterized flagellar protein FlaG:Arsenate reductase and related proteins, glutaredoxin family:Hemerythrin:Cytochrome c553:Collagen-binding surface adhesin SpaP (antigen I/II family):Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Valine leucine and isoleucine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Thiamine metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:RNA polymerase:General function prediction only:ilvD:rpoC_TIGR:hemeryth_dom:lp_:Poorly characterized:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Transcription:Global:Metabolism:Transcription:DNA-dependent RNA polymerase:Amino acid biosynthesis:Pyruvate family:Cell envelope:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 91 "Energy production and conversion:F0F1-type ATP synthase, alpha subunit:Phosphoribosylpyrophosphate synthetase:Pyruvate kinase:ATPase components of ABC transporters with duplicated ATPase domains:SAM-dependent methyltransferases:Ribosomal protein S1:Predicted phosphatases:Na+/proline symporter:Protease subunit of ATP-dependent Clp proteases:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type polar amino acid transport system, ATPase component:Flagellar basal body-associated protein:Rubrerythrin:Cytochrome c peroxidase:Cytochrome c553:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Oxidative phosphorylation:Purine metabolism:Pyruvate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Bacterial chemotaxis:Flagellar assembly:Ribosome:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:desulf_FeS4:clpP:sss:atpA:pyruv_kin:ribP_PPkin:HEQRo_perm_3TM:Pal_lipo:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Cations and iron carrying compounds:Amino acids, peptides and amines:Transport and binding proteins:Degradation of proteins, peptides, and glycopeptides:Protein fate:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Glycolysis/gluconeogenesis:Electron transport:ATP-proton motive force interconversion:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Nucleotide Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling" 92 "5-formyltetrahydrofolate cyclo-ligase:Metal-dependent proteases with possible chaperone activity:CDP-diglyceride synthetase:1-deoxy-D-xylulose 5-phosphate reductoisomerase:Molybdopterin-guanine dinucleotide biosynthesis protein A:ABC-type amino acid transport system, permease component:ABC-type transport system involved in resistance to organic solvents, permease component:Predicted transcriptional regulators:Predicted RNA-binding protein homologous to eukaryotic snRNP:DNA/RNA endonuclease G, NUC1:Sialic acid synthase:1-aminocyclopropane-1-carboxylate deaminase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Propanoate metabolism:One carbon pool by folate:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:TIGR00056:Dxr:gcp_kae1:HEQRo_perm_3TM:IV_pilin_GFxxxE:MTHFS_bact:Poorly characterized:Carbohydrate Metabolism:Lipid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:One-carbon metabolism:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Amino acids, peptides and amines:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 93 "Energy production and conversion:Molecular chaperone:ATPases with chaperone activity, ATP-binding subunit:ABC-type antimicrobial peptide transport system, permease component:High-affinity Fe2+/Pb2+ permease:Hemoglobin-like flavoprotein:ABC-type antimicrobial peptide transport system, ATPase component:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Truncated hemoglobins:Uncharacterized protein probably involved in high-affinity Fe2+ transport:Predicted membrane protein:ABC-type transport system, involved in lipoprotein release, permease component:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Aminoacyl-tRNA biosynthesis:RNA degradation:General function prediction only:Function unknown:prok_dnaK:Defense mechanisms:Genetic Information Processing:Poorly characterized:Metabolism:Cellular processes and signaling:Protein folding and stabilization:Protein fate:Folding Sorting and Degradation:Translation" 94 "Energy production and conversion:Isoleucyl-tRNA synthetase:Phosphoribosylaminoimidazole (AIR) synthetase:Peptidyl-tRNA hydrolase:Translation initiation factor 1 (IF-1):Aspartate/tyrosine/aromatic aminotransferase:ATPases involved in chromosome partitioning:Enoyl-[acyl-carrier-protein] reductase (NADH):Chemotaxis protein histidine kinase and related kinases:Small-conductance mechanosensitive channel:Bacterial nucleoid DNA-binding protein:Chemotaxis signal transduction protein:NADH:ubiquinone oxidoreductase 27 kD subunit:NADH:ubiquinone oxidoreductase subunit 1 (chain H):Flagellin and related hook-associated proteins:Uncharacterized protein conserved in bacteria:ABC-type metal ion transport system, periplasmic component/surface antigen:Protein-L-isoaspartate carboxylmethyltransferase:Uncharacterized protein involved in formation of periplasmic nitrate reductase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Oxidative phosphorylation:Purine metabolism:Valine leucine and isoleucine biosynthesis:Nitrogen metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Flagellar assembly:Function unknown:Signal transduction mechanisms:infA:pimt:ileS:mauM_napG:pth:purM:NuoC_fam:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Electron transport:Energy metabolism:Metabolism:Global:Metabolism:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Translation:Genetic Information Processing:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Protein fate:Energy Metabolism:Protein modification and repair:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation factors:tRNA aminoacylation:Other:Protein synthesis" 95 "Energy production and conversion:Peptidyl-tRNA hydrolase:Glycerol-3-phosphate dehydrogenase:Anaerobic dehydrogenases, typically selenocysteine-containing:GTP cyclohydrolase I:NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases:Phosphoribosylpyrophosphate synthetase:CTP synthase (UTP-ammonia lyase):NADH:ubiquinone oxidoreductase 49 kD subunit 7:F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein):UDP-N-acetylmuramate-alanine ligase:Transcription elongation factor:NADH:ubiquinone oxidoreductase subunit 3 (chain A):ABC-type metal ion transport system, periplasmic component/surface antigen:Ribosomal protein L25 (general stress protein Ctc):Allophanate hydrolase subunit 1:Membrane transporters of cations and cationic drugs:Permeases:Predicted nucleic-acid-binding protein implicated in transcription termination:Predicted membrane protein:Site-specific recombinase XerD:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose phosphate pathway:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:D-Glutamine and D-glutamate metabolism:Peptidoglycan biosynthesis:Glycerophospholipid metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Ribosome:General function prediction only:Function unknown:folE:PyrG:TIGR00370:pth:ctc_TL5:murC:ATP_synt_delta:ribP_PPkin:TAT_signal_seq:greA:nuoB_fam:NuoD:Cell envelope:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Electron transport:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:Transcription:Transcription factors:Protein synthesis:Other:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 96 "Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Predicted Co/Zn/Cd cation transporters:Acetyltransferase (isoleucine patch superfamily):7-keto-8-aminopelargonate synthetase and related enzymes:Superfamily I DNA and RNA helicases:Protoheme ferro-lyase (ferrochelatase):Predicted GTPase:Predicted GTPase:Acetylglutamate kinase:Cell division protein FtsI/penicillin-binding protein 2:UDP-N-acetylmuramate dehydrogenase:A/G-specific DNA glycosylase:Predicted membrane protein:Leu/Phe-tRNA-protein transferase:Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen:Ornithine/acetylornithine aminotransferase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Lysine biosynthesis:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Biotin metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Base excision repair:Nucleotide excision repair:Mismatch repair:General function prediction only:Function unknown:hemH:murB:small_GTP:aat:argD:argB:mutY:CDF:lysidine_TilS_N:Obg_CgtA:pbp2_mrdA:NeuD_NnaD:Cell envelope:Carbohydrate Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Other:tRNA and rRNA base modification:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Cations and iron carrying compounds:Unknown function:General:Amino acid biosynthesis:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 97 "Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Ribosomal protein S16:Predicted redox protein, regulator of disulfide bond formation:Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains:Pseudouridylate synthases, 23S RNA-specific:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Predicted RNA-binding protein (contains KH domain):Uncharacterized conserved protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:ABC transporters:Ribosome:General function prediction only:Function unknown:Signal transduction mechanisms:S16:rluA_subfam:glmS:selenium_YedF:WbuX:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification:Protein synthesis:Amino sugars:Central intermediary metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Amino Acid Metabolism:Carbohydrate Metabolism" 98 "Energy production and conversion:Imidazoleglycerol-phosphate dehydratase:Argininosuccinate synthase:Orotidine-5'-phosphate decarboxylase:3-oxoacyl-(acyl-carrier-protein) synthase:Cytosine deaminase and related metal-dependent hydrolases:Ketopantoate hydroxymethyltransferase:Prolyl-tRNA synthetase:GMP synthase, PP-ATPase domain/subunit:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:UDP-galactopyranose mutase:Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):ABC-type amino acid transport system, permease component:UDP-N-acetylglucosamine enolpyruvyl transferase:DNA polymerase III, epsilon subunit and related 3'-5' exonucleases:Uncharacterized bacitracin resistance protein:Molybdopterin converting factor, small subunit:Predicted membrane-associated, metal-dependent hydrolase:Hemerythrin:Cytochrome c553:Uncharacterized protein conserved in bacteria:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Histidine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:DNA replication:Mismatch repair:Homologous recombination:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:UDP-GALP_mutase:argG:panB:proS_fam_II:dnaq:undec_PP_bacA:guaA_Cterm:murA:hisB_Nterm:DAHP_synth_II:HEQRo_perm_3TM:pyrF:hemeryth_dom:fabF:Defense mechanisms:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:DNA metabolism:Degradation of DNA:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Amino acids, peptides and amines:Amino acid biosynthesis:Aromatic amino acid family:Glutamate family:Histidine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 99 "Ribosomal protein S16:ABC-type polysaccharide/polyol phosphate transport system, ATPase component:Primosomal protein N' (replication factor Y) - superfamily II helicase:Flagellar biosynthesis/type III secretory pathway protein:Predicted Na+/dicarboxylate symporter:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:ABC transporters:Flagellar assembly:Ribosome:Homologous recombination:General function prediction only:S16:priA:Intracellular trafficking, secretion, and vesicular transport:Ribosomal proteins: synthesis and modification:Translation:Replication and Repair:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Genetic Information Processing:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 100 "Indole-3-glycerol phosphate synthase:Predicted membrane-associated Zn-dependent proteases 1:Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis:ADP-heptose:LPS heptosyltransferase:Flagellar motor switch protein:Predicted O-methyltransferase:Amino acid transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Phenylalanine tyrosine and tryptophan biosynthesis:Lipopolysaccharide biosynthesis:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Flagellar assembly:Ribosome:General function prediction only:TIGR00054:ispG_gcpE:fliM_switch:heptsyl_trn_I:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Chemotaxis and motility:Metabolism:Other:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Poorly characterized" 101 "Energy production and conversion:Malate/lactate dehydrogenases:Acetyltransferase (isoleucine patch superfamily):UDP-N-acetylglucosamine 2-epimerase:Apolipoprotein N-acyltransferase:Biopolymer transport protein:ADP-heptose:LPS heptosyltransferase:CMP-N-acetylneuraminic acid synthetase:ABC-type sulfate/molybdate transport systems, ATPase component:Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Organic solvent tolerance protein OstA:ABC-type transport system involved in resistance to organic solvents, periplasmic component:Nicotinic acid phosphoribosyltransferase:Uncharacterized proteins of the AP superfamily:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Methylase of polypeptide chain release factors:ABC-type uncharacterized transport system, auxiliary component:Capsule polysaccharide export protein:McrBC 5-methylcytosine restriction system component:ABC-type siderophore export system, fused ATPase and permease components:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Cysteine and methionine metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Pyruvate metabolism:Propanoate metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:hemK_fam:lnt:cyc_pep_trnsptr:NAPRTase_put:heptsyl_trn_I:NeuC_NnaA:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Information storage and processing:Carbohydrate Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein fate:Protein modification and repair:Transport and binding proteins:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 102 "Energy production and conversion:Ketol-acid reductoisomerase:Fumarase:Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases:Acyl carrier protein:Ribosomal protein S6:Aspartate/tyrosine/aromatic aminotransferase:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Uncharacterized homolog of plant Iojap protein:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Phosphomannomutase:Predicted membrane GTPase involved in stress response:Zn-ribbon protein, possibly nucleic acid-binding:Phosphoenolpyruvate carboxykinase (ATP):FOG: PAS/PAC domain:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Valine leucine and isoleucine biosynthesis:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Carbon fixation pathways in prokaryotes:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Ribosome:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:iojap_ybeB:gatA:S6:pckA:sensory_box:small_GTP:ilvC:acyl_carrier:fumC_II:glmM:Amino acid biosynthesis:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Amino sugars:Energy metabolism:Glycolysis/gluconeogenesis:TCA cycle:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Unknown function:General:Metabolism:Pyruvate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 103 "Ribosome recycling factor:Fucose permease:CMP-2-keto-3-deoxyoctulosonic acid synthetase:Protein-disulfide isomerase:Arabinose efflux permease:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Lipopolysaccharide biosynthesis:Metabolic pathways:Ribosome:kdsB:frr:fucP:rpmH_bact:Transport and binding proteins:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Translation:Global:Metabolism:Protein synthesis:Ribosomal proteins: synthesis and modification:Translation factors:Metabolism:Carbohydrates, organic alcohols, and acids:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism" 104 "Acetylglutamate semialdehyde dehydrogenase:Undecaprenyl pyrophosphate synthase:Pseudouridylate synthase:Phosphoribosylanthranilate isomerase:AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful):Anthranilate/para-aminobenzoate synthases component I:7-keto-8-aminopelargonate synthetase and related enzymes:Tryptophan synthase alpha chain:FAD synthase:3-oxoacyl-[acyl-carrier-protein] synthase III:Cytosine deaminase and related metal-dependent hydrolases:ABC-type branched-chain amino acid transport systems, ATPase component:Acetyltransferases:Anthranilate phosphoribosyltransferase:Acetylglutamate kinase:UDP-N-acetylmuramoylalanine-D-glutamate ligase:Predicted permeases:Diacylglycerol kinase:Predicted amidophosphoribosyltransferases:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains):Predicted membrane protein:Flagellar biosynthesis pathway, component FliP:Predicted membrane protein:Type II secretory pathway, prepilin signal peptidase PulO and related peptidases:ABC-type branched-chain amino acid transport system, permease component:Ornithine/acetylornithine aminotransferase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Purine metabolism:Glycine serine and threonine metabolism:Lysine biosynthesis:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:D-Glutamine and D-glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:One carbon pool by folate:Riboflavin metabolism:Biotin metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Flagellar assembly:Bacterial secretion system:General function prediction only:Function unknown:uppS:hisT_truA:trpA:purH:trpG_papA:argD:OPT_sfam:fabH:argB:murD:fliP:glmU:argC:Intracellular trafficking, secretion, and vesicular transport:Amino sugars:Central intermediary metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Metabolism:Membrane Transport:Environmental Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Protein synthesis:Carbohydrate Metabolism:tRNA and rRNA base modification:Cellular processes:Chemotaxis and motility:Amino acid biosynthesis:Aromatic amino acid family:Glutamate family:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Biosynthesis:Fatty acid and phospholipid metabolism" 105 "Acetyltransferase (isoleucine patch superfamily):Pseudouridine synthase:Excinuclease ATPase subunit:Type I restriction-modification system methyltransferase subunit:Predicted Fe-S oxidoreductases:Predicted ATPase with chaperone activity:Methionine synthase II (cobalamin-independent):ABC-type sulfate/molybdate transport systems, ATPase component:Uncharacterized protein conserved in bacteria:ABC-type uncharacterized transport system, auxiliary component:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Ribosome:Nucleotide excision repair:General function prediction only:Function unknown:TIGR00368:TruB:uvra:met_syn_B12ind:Defense mechanisms:Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Unknown function:General:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 106 "Molybdopterin biosynthesis enzyme:3-oxoacyl-[acyl-carrier-protein] synthase III:Thiamine monophosphate synthase:Recombinational DNA repair protein (RecF pathway):Glycosyltransferase:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake:Type II restriction enzyme, methylase subunits:Predicted GTPases:RecG-like helicase:Flagellar biosynthesis pathway, component FlhB:Uncharacterized conserved protein:Molybdopterin converting factor, small subunit:Sulfur transfer protein involved in thiamine biosynthesis:Predicted ATPase:G:T/U mismatch-specific DNA glycosylase:ABC-type enterochelin transport system, permease component:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Lysine biosynthesis:Thiamine metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Flagellar assembly:Bacterial secretion system:Homologous recombination:Sulfur relay system:General function prediction only:Function unknown:small_GTP:flhB:recR:dapE_proteo:thiS:IV_pilin_GFxxxE:tRNA_sel_U_synt:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Amino acid biosynthesis:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Chemotaxis and motility:Unknown function:General:Metabolism:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 107 "ABC-type antimicrobial peptide transport system, permease component:High-affinity Fe2+/Pb2+ permease:Biopolymer transport proteins:Biopolymer transport protein:ABC-type antimicrobial peptide transport system, ATPase component:Disulfide bond formation protein DsbB:Outer membrane receptor proteins, mostly Fe transport:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Sulfite oxidase and related enzymes:Peroxiredoxin:Truncated hemoglobins:Uncharacterized protein probably involved in high-affinity Fe2+ transport:Predicted membrane protein:ABC-type transport system, involved in lipoprotein release, permease component:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Aminoacyl-tRNA biosynthesis:Bacterial secretion system:General function prediction only:Function unknown:ExbD_2:exbB2:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Genetic Information Processing:Translation:Poorly characterized:Metabolism:Cellular processes and signaling:Cations and iron carrying compounds:Transport and binding proteins:Membrane Transport:Environmental Information Processing" 108 "Adenylosuccinate lyase:UDP-N-acetylglucosamine 2-epimerase:Predicted amidohydrolase:Glycosyltransferases involved in cell wall biogenesis:Predicted Fe-S oxidoreductases:Rhodanese-related sulfurtransferase:Cystathionine beta-lyases/cystathionine gamma-synthases:ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains):ABC-type transport system involved in resistance to organic solvents, periplasmic component:Adenine-specific DNA methylase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Selenocompound metabolism:Amino sugar and nucleotide sugar metabolism:Nitrogen metabolism:Sulfur metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:purB:NeuC_NnaA:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Replication and Repair:Translation:Genetic Information Processing:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism" 109 "Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase:Acetyltransferase (isoleucine patch superfamily):Tryptophan synthase alpha chain:Exopolyphosphatase:Phosphoheptose isomerase:Thiamine monophosphate synthase:Glycosyltransferase:Nucleoside-diphosphate-sugar epimerases:Acetyltransferases:Adenylylsulfate kinase and related kinases:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Predicted dehydrogenases and related proteins:Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake:Cell division protein FtsI/penicillin-binding protein 2:Predicted sugar phosphate isomerase involved in capsule formation:Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis):dTDP-D-glucose 4,6-dehydratase:A/G-specific DNA glycosylase:Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Predicted ATPase (AAA+ superfamily):Metal-dependent amidase/aminoacylase/carboxypeptidase:Predicted glutamine amidotransferases:Membrane transporters of cations and cationic drugs:Sugar transferases involved in lipopolysaccharide synthesis:Leu/Phe-tRNA-protein transferase:Uncharacterized protein conserved in bacteria:Predicted kinase related to galactokinase and mevalonate kinase:Uncharacterized protein conserved in bacteria:Predicted hydrolase (HAD superfamily):Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Purine metabolism:Glycine serine and threonine metabolism:Histidine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Selenocompound metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Peptidoglycan biosynthesis:Thiamine metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Base excision repair:General function prediction only:Function unknown:TIGR00007:RNAse_H_YqgF:trpA:kpsF:aat:thiE:mutY:HAD-SF-IA-v1:amidohydrolases:pbp2_mrdA:NeuD_NnaD:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope:Thiamine:Biosynthesis of cofactors, prosthetic groups, and carriers:Histidine family:Aromatic amino acid family:Amino acid biosynthesis:General:Enzymes of unknown specificity:Unknown function:Degradation of proteins, peptides, and glycopeptides:Protein fate:DNA replication, recombination, and repair:DNA metabolism:Sugars:Energy metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism" 110 "Energy production and conversion:Gamma-glutamyl phosphate reductase:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Malate/lactate dehydrogenases:Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog):Chorismate synthase:3,4-dihydroxy-2-butanone 4-phosphate synthase:3-phosphoglycerate kinase:Triosephosphate isomerase:Cysteinyl-tRNA synthetase:F0F1-type ATP synthase, gamma subunit:Riboflavin synthase alpha chain:Acetolactate synthase, small (regulatory) subunit:RecA/RadA recombinase:Predicted Zn-dependent peptidases:Putative intracellular protease/amidase:Collagenase and related proteases:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase:N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains):Methylase of chemotaxis methyl-accepting proteins:Uncharacterized conserved protein:Uncharacterized bacitracin resistance protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Fructose and mannose metabolism:Oxidative phosphorylation:Valine leucine and isoleucine biosynthesis:Lysine degradation:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Peptidoglycan biosynthesis:Inositol phosphate metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Riboflavin metabolism:Pantothenate and CoA biosynthesis:Biotin metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:aroC:acolac_lg:acolac_sm:gatB:ribE:proA:cysS:ribB:undec_PP_bacA:ATPsyn_F1gamma:glmU:not_thiJ:lipid_A_lpxD:tigrfam_recA:Defense mechanisms:Biosynthesis of cofactors, prosthetic groups, and carriers:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Amino sugars:Energy metabolism:ATP-proton motive force interconversion:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Unknown function:General:Amino acid biosynthesis:Aromatic amino acid family:Glutamate family:Pyruvate family:Metabolism:Riboflavin, FMN, and FAD:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 111 "Energy production and conversion:Cysteine synthase:ATP phosphoribosyltransferase:Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain:F0F1-type ATP synthase, beta subunit:Ribosomal protein S9:Delta-aminolevulinic acid dehydratase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Histidinol dehydrogenase:Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase:Ribosomal protein L17:Putative translation initiation inhibitor, yjgF family:Ribosomal protein L21:Ribosomal protein L20:Molecular chaperone, HSP90 family:Membrane protease subunits, stomatin/prohibitin homologs:Preprotein translocase subunit SecF:F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit):Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains:Phosphatidylglycerophosphate synthase:Superoxide dismutase:F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K:Flavodoxins:Nucleoside phosphorylase:Periplasmic protease:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):UDP-glucose 4-epimerase:Phosphomannomutase:LuxS protein involved in autoinducer AI2 synthesis:Preprotein translocase subunit YajC:Di- and tripeptidases:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Galactose metabolism:Oxidative phosphorylation:Purine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Histidine metabolism:beta-Alanine metabolism:Selenocompound metabolism:Glutathione metabolism:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Pantothenate and CoA biosynthesis:Porphyrin and chlorophyll metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:TIGR00004:L17:L21:hisD:hisG:purC:prc:pgsA:yajC:2A0604s01:rplT_bact:atpD:ilvE_I:glmS:cysKM:galE:ATP_synt_epsi:ATP_synt_c:MTA/SAH-Nsdase:FGAM_synth_I:flav_long:autotrns_rpt:Intracellular trafficking, secretion, and vesicular transport:Pyruvate family:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Amino sugars:Energy metabolism:ATP-proton motive force interconversion:Electron transport:Sugars:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Salvage of nucleosides and nucleotides:Transcription:Degradation of RNA:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Cellular processes:Pathogenesis:Amino acid biosynthesis:Metabolism:Serine family:Histidine family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 112 "Cell division GTPase:DNA polymerase III, alpha subunit:ABC-type metal ion transport system, periplasmic component/surface adhesin:Membrane protein TerC, possibly involved in tellurium resistance:Transthyretin-like protein:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Replication, recombination and repair:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:ftsZ:polc:hdxy_isourate:Other:Nucleotide Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Cellular processes:Cell division:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 113 "Energy production and conversion:Adenylosuccinate synthase:Fe-S oxidoreductase:L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D:Translation initiation factor 3 (IF-3):Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Purine metabolism:Alanine aspartate and glutamate metabolism:Cyanoamino acid metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:infC:purA:asnASE_II:Energy metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Global:Metabolism:Metabolism:Amino acids and amines:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:Translation factors:Information storage and processing:Metabolism" 114 "Cell division GTPase:Integral membrane protein, interacts with FtsH:ABC-type polysaccharide/polyol phosphate export systems, permease component:Predicted transcriptional regulator:Uncharacterized conserved protein:DNA uptake lipoprotein:Accessory colonization factor AcfC, contains ABC-type periplasmic domain:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:ABC transporters:General function prediction only:Function unknown:ftsZ:rrf2_super:Unknown function:Cell division:Cellular processes:Cellular processes and signaling:Membrane Transport:Metabolism:Poorly characterized:Environmental Information Processing:Information storage and processing:General" 115 "Energy production and conversion:Hydrogenase maturation factor:Molecular chaperone GrpE (heat shock protein):Superoxide dismutase:ABC-type Fe3+-siderophore transport system, permease component:Biopolymer transport proteins:NifU homolog involved in Fe-S cluster formation:Methyl-accepting chemotaxis protein:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Transcriptional regulator of heat shock gene:Uncharacterized protein required for formate dehydrogenase activity:Peroxiredoxin:Uncharacterized component of anaerobic dehydrogenases:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Thiamine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Sulfur relay system:General function prediction only:Function unknown:Signal transduction mechanisms:hypC_hupF:fdhD_narQ:exbB2:nifS_epsilon:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Carbohydrate Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Protein fate:Protein modification and repair:Transport and binding proteins:Cations and iron carrying compounds:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 116 "Gamma-glutamyl phosphate reductase:Pentose-5-phosphate-3-epimerase:Predicted EndoIII-related endonuclease:2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway):Molybdopterin biosynthesis enzyme:Replicative DNA helicase:Glycosyltransferases involved in cell wall biogenesis:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Signal recognition particle GTPase:Signal recognition particle GTPase:Ribose 5-phosphate isomerase RpiB:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:Bacterial cell division membrane protein:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Flagellar basal body P-ring biosynthesis protein:Flagellar biosynthesis pathway, component FliR:Sec-independent protein secretion pathway components:Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component:Allophanate hydrolase subunit 2:Predicted O-methyltransferase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Pentose phosphate pathway:Pentose and glucuronate interconversions:Purine metabolism:Arginine and proline metabolism:Peptidoglycan biosynthesis:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Flagellar assembly:DNA replication:Protein export:Bacterial secretion system:Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:ftsY:TIGR00302:proA:DnaB:rpiB_lacA_lacB:urea_amlyse_rel:ffh:nth:murG:rpe:fliR:tatB:folK:ftsW:flgA_cterm:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis and degradation of murein sacculus and peptidoglycan:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Pentose phosphate pathway:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Cell division:Chemotaxis and motility:Unknown function:General:Amino acid biosynthesis:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 117 "Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Anthranilate/para-aminobenzoate synthases component I:Transaldolase:Dihydropteroate synthase and related enzymes:Folate-dependent phosphoribosylglycinamide formyltransferase PurN:Fatty acid/phospholipid biosynthesis enzyme:Kef-type K+ transport systems, membrane components:Anthranilate phosphoribosyltransferase:Uncharacterized membrane-associated protein:ABC-type amino acid transport system, permease component:Cation/multidrug efflux pump:GTPase:Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Inactive homolog of metal-dependent proteases, putative molecular chaperone:Uncharacterized membrane protein, required for N-linked glycosylation:Type II secretory pathway, component PulD:Sialic acid synthase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Capsule polysaccharide export protein:ABC-type molybdate transport system, permease component:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Purine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:One carbon pool by folate:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Bacterial secretion system:General function prediction only:Function unknown:plsX:small_GTP:trpG_papA:PurN:tal_mycobact:DHPS:HEQRo_perm_3TM:modB_ABC:pilus_MshL:NeuB_NnaB:WbuX:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Cellular processes and signaling:Information storage and processing:Surface structures:Cell envelope:Folic acid:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Unknown function:Anions:Amino acids, peptides and amines:Transport and binding proteins:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Biosynthesis:Fatty acid and phospholipid metabolism:Pentose phosphate pathway:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Poorly characterized:Metabolism" 118 "Transketolase:N-formylmethionyl-tRNA deformylase:Putative translation initiation inhibitor, yjgF family:Ribonuclease HI:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Uroporphyrinogen-III decarboxylase:Glycosyltransferases involved in cell wall biogenesis:Leucyl-tRNA synthetase:dsRNA-specific ribonuclease:Membrane proteins related to metalloendopeptidases:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Uroporphyrinogen-III synthase:Preprotein translocase subunit YajC:Sugar transferases involved in lipopolysaccharide synthesis:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Pentose phosphate pathway:Valine leucine and isoleucine biosynthesis:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:DNA replication:Protein export:Bacterial secretion system:Signal transduction mechanisms:TIGR00004:pept_deformyl:HMP-P_kinase:tktlase_bact:leuS_bact:yajC:hemE:RNaseIII:Intracellular trafficking, secretion, and vesicular transport:Thiamine:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Pentose phosphate pathway:Transcription:Degradation of RNA:RNA processing:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism" 119 "Energy production and conversion:Succinyl-CoA synthetase, beta subunit:Glutamate synthase domain 2:Fe-S oxidoreductase:Phosphotransacetylase:Acetate kinase:Citrate synthase:Ribosomal protein S1:Aconitase B:Uncharacterized conserved protein containing a ferredoxin-like domain:Uncharacterized conserved protein:Uncharacterized proteins, homologs of lactam utilization protein B:Uncharacterized conserved protein:L-lactate permease:Sugar phosphate permease:Uncharacterized conserved protein:Altronate dehydratase:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Predicted membrane protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Citrate cycle (TCA cycle):Pentose and glucuronate interconversions:Alanine aspartate and glutamate metabolism:Taurine and hypotaurine metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:C5-Branched dibasic acid metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:General function prediction only:Function unknown:ackA:acnB:TIGR00273:pta:lctP:sucCoAbeta:cit_synth_I:PPK2_P_aer:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Translation:Global:Metabolism:Central intermediary metabolism:Phosphorus compounds:Energy metabolism:Electron transport:Fermentation:TCA cycle:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Information storage and processing:Metabolism:Metabolism" 120 "Energy production and conversion:Protein chain release factor A:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:ATPases involved in chromosome partitioning:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Predicted Zn-dependent peptidases:F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein):GTP cyclohydrolase II:UDP-glucose pyrophosphorylase:3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase:Uncharacterized proteins, homologs of lactam utilization protein B:ABC-type polysaccharide/polyol phosphate export systems, permease component:Allophanate hydrolase subunit 1:Methylase involved in ubiquinone/menaquinone biosynthesis:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Predicted membrane protein:Predicted membrane protein:Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Pentose and glucuronate interconversions:Galactose metabolism:Oxidative phosphorylation:Lysine degradation:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Riboflavin metabolism:Biotin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Flagellar assembly:General function prediction only:Function unknown:prfB:TIGR00370:dhsB:ribA:galU:ATP_synt_delta:Pal_lipo:PseC:PseB:TCA cycle:ATP-proton motive force interconversion:Energy metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Metabolism:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Protein synthesis:Carbohydrate Metabolism:Translation factors:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 121 "Energy production and conversion:3-phosphoglycerate kinase:Glutamine synthetase:Predicted S-adenosylmethionine-dependent methyltransferase:Glutamate 5-kinase:Chaperonin GroEL (HSP60 family):Nitroreductase:DNA-binding ferritin-like protein (oxidative damage protectant):NAD-dependent protein deacetylases, SIR2 family:Non-ribosomal peptide synthetase modules and related proteins:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Na+/H+-dicarboxylate symporters:Arsenate reductase and related proteins, glutaredoxin family:Na+/H+ antiporter:AraC-type DNA-binding domain-containing proteins:Uncharacterized protein conserved in bacteria:Aminoglycoside N3'-acetyltransferase:ABC-type enterochelin transport system, ATPase component:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00091:TIGR00423:GlnA:proB:GroEL:Defense mechanisms:tRNA and rRNA base modification:Protein synthesis:Metabolism:Global:Metabolism:Signal Transduction:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Amino Acid Metabolism:Energy Metabolism:Glutamate family:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Amino acid biosynthesis:Conserved:Hypothetical proteins:Protein folding and stabilization:Protein fate" 122 "Transaldolase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Queuine/archaeosine tRNA-ribosyltransferase:Glutamyl-tRNA reductase:Phosphoserine phosphatase:Predicted Zn-dependent peptidases:UDP-N-acetylmuramyl pentapeptide synthase:Alanine racemase:Transcriptional regulator:Organic solvent tolerance protein OstA:Predicted periplasmic solute-binding protein:Exonuclease VII, large subunit:Uncharacterized conserved protein:Predicted enzyme involved in methoxymalonyl-ACP biosynthesis:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Pentose phosphate pathway:Glycine serine and threonine metabolism:Lysine biosynthesis:Lysine degradation:D-Alanine metabolism:Peptidoglycan biosynthesis:Glycerophospholipid metabolism:Methane metabolism:Biotin metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Mismatch repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:xseA:TIGR00247:serB:Q_tRNA_tgt:alr:tal_mycobact:hemA:HAD-SF-IIIC:Cell envelope:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Energy metabolism:Pentose phosphate pathway:DNA metabolism:Degradation of DNA:Protein synthesis:tRNA and rRNA base modification:Hypothetical proteins:Conserved:Amino acid biosynthesis:Serine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 123 "Uncharacterized conserved protein:Ribosomal protein L28:Ribosomal protein L31:Aspartokinases:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:ABC-type molybdate transport system, periplasmic component:Uncharacterized homolog of plant Iojap protein:Aspartate 1-decarboxylase:Flagellar motor protein:Putative transcriptional regulator, homolog of Bvg accessory factor:Acetyltransferases, including N-acetylases of ribosomal proteins:Fe2+ transport system protein A:Membrane transporters of cations and cationic drugs:Cyanate permease:Uncharacterized protein conserved in bacteria:ABC-type tungstate transport system, permease component:Predicted metal-binding protein:ABC-type molybdate transport system, permease component:Accessory colonization factor AcfC, contains ABC-type periplasmic domain:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:beta-Alanine metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Bacterial chemotaxis:Flagellar assembly:Ribosome:General function prediction only:Function unknown:L28:iojap_ybeB:L31:panD:asp_kin_monofn:baf:TIGR01033:modA:modB_ABC:PseH:Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:DNA interactions:Protein synthesis:Ribosomal proteins: synthesis and modification:Transport and binding proteins:Anions:Unknown function:General:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 124 "tRNA and rRNA cytosine-C5-methylases:Molybdopterin-guanine dinucleotide biosynthesis protein A:ABC-type amino acid transport system, permease component:Uncharacterized protein conserved in bacteria:Outer membrane phospholipase A:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Glycerophospholipid metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Function unknown:HEQRo_perm_3TM:adhes_NPXG:Information storage and processing:Lipid Metabolism:Genetic Information Processing:Translation:Global:Metabolism:Transport and binding proteins:Amino acids, peptides and amines:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 125 "Energy production and conversion:Predicted sugar kinase:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Hydrogenase maturation factor:Glycosyltransferase:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:Translation initiation factor 2 (IF-2; GTPase):2-methylthioadenine synthetase:F0F1-type ATP synthase, subunit b:Penicillin tolerance protein:Alanine racemase:Ribosome-binding factor A:Ni,Fe-hydrogenase I small subunit:Predicted nucleic-acid-binding protein implicated in transcription termination:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Histidine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:D-Alanine metabolism:Peptidoglycan biosynthesis:Nicotinate and nicotinamide metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:hypD:rbfA:TIGR00089:ispH_lytB:small_GTP:hydA:mraY:alr:Cell envelope:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Electron transport:Transcription:RNA processing:Protein fate:Protein modification and repair:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism" 126 "Energy production and conversion:Succinyl-CoA synthetase, beta subunit:Succinyl-CoA synthetase, alpha subunit:Anaerobic dehydrogenases, typically selenocysteine-containing:Fe-S oxidoreductase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Amino acid permeases:Aconitase B:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Uncharacterized conserved protein containing a ferredoxin-like domain:Ferredoxin:Uncharacterized conserved protein:L-lactate permease:L-serine deaminase:Succinate dehydrogenase/fumarate reductase, cytochrome b subunit:Monomeric isocitrate dehydrogenase:Cbb3-type cytochrome oxidase, cytochrome c subunit:Cbb3-type cytochrome oxidase, subunit 1:Short-chain alcohol dehydrogenase of unknown specificity:Amino acid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Oxidative phosphorylation:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Glutathione metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:acnB:monomer_idh:TIGR00273:sda_mono:ccoN:ccoO:lctP:sucCoAbeta:sucCoAalpha:TAT_signal_seq:sdhA_frdA_Gneg:Poorly characterized:Metabolism:Cellular processes and signaling:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:TCA cycle:Glycolysis/gluconeogenesis:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism of Other Amino Acids:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism" 127 "Energy production and conversion:Imidazoleglycerol-phosphate synthase:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Na+/proline symporter:Mg2+ and Co2+ transporters:F0F1-type ATP synthase, subunit b:ABC-type amino acid transport system, permease component:Methyl-accepting chemotaxis protein:Predicted nucleoside-diphosphate sugar epimerases:Lysyl-tRNA synthetase (class II):Sialic acid synthase:Putative multicopper oxidases:Methylase involved in ubiquinone/menaquinone biosynthesis:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized protein, possibly involved in nitrogen fixation:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Oxidative phosphorylation:Lysine biosynthesis:Histidine metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:corA:lysS_bact:dapA:hisF:sss:ccoS:HEQRo_perm_3TM:PseI:PPK2_P_aer:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Phosphorus compounds:Protein synthesis:tRNA aminoacylation:Protein fate:Protein modification and repair:Transport and binding proteins:Amino acids, peptides and amines:Cations and iron carrying compounds:Amino acid biosynthesis:Aspartate family:Histidine family:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 128 "Energy production and conversion:Dimethyladenosine transferase (rRNA methylation):Ribosomal protein S9:Ribosomal protein L15:Preprotein translocase subunit SecY:5-formyltetrahydrofolate cyclo-ligase:Methionyl-tRNA formyltransferase:ABC-type branched-chain amino acid transport systems, ATPase component:Predicted divalent heavy-metal cations transporter:Peroxiredoxin:Glycosyltransferases involved in cell wall biogenesis:Branched-chain amino acid ABC-type transport system, permease components:Predicted hydrolase of the metallo-beta-lactamase superfamily:Predicted dehydrogenases and related proteins:ABC-type branched-chain amino acid transport systems, periplasmic component:Catalase:ABC-type transport system involved in cytochrome c biogenesis, permease component:Cation/multidrug efflux pump:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:ATPases involved in chromosome partitioning:Co/Zn/Cd efflux system component:Cytochrome bd-type quinol oxidase, subunit 2:Predicted ATPase (AAA+ superfamily):Predicted transcriptional regulators:Arabinose efflux permease:ABC-type branched-chain amino acid transport system, permease component:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Tryptophan metabolism:One carbon pool by folate:Methane metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Ribosome:RNA degradation:Protein export:Bacterial secretion system:General function prediction only:TIGR00093:parB_part:cydB:fmt:MG423:ksgA:3a0501s007:rplO_bact:CDF:MTHFS_bact:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Transport and binding proteins:Energy Metabolism:Cations and iron carrying compounds:Hypothetical proteins:Conserved:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Protein and peptide secretion and trafficking:Protein fate:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification:tRNA aminoacylation:Protein synthesis:Electron transport:Energy metabolism:One-carbon metabolism:Central intermediary metabolism" 129 "Phosphate/sulphate permeases:Fe2+ transport system protein B:ATP-dependent Lon protease, bacterial type:Predicted acid phosphatase:Holliday junction resolvasome, DNA-binding subunit:Formyltetrahydrofolate hydrolase:D-alanine-D-alanine ligase and related ATP-grasp enzymes:Flagellar biosynthesis pathway, component FlhB:DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog:Micrococcal nuclease (thermonuclease) homologs:Flagellar biosynthesis pathway, component FliR:Uncharacterized protein conserved in bacteria:Bacterial lipocalin:Nucleotide transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:D-Alanine metabolism:Peptidoglycan biosynthesis:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:Nicotinate and nicotinamide metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Flagellar assembly:RNA polymerase:Homologous recombination:General function prediction only:Function unknown:ruvA:surE:small_GTP:flhB:PurU:lon:D_ala_D_alaTIGR:fliR:rpoN_sigma:Intracellular trafficking, secretion, and vesicular transport:Unknown function:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Adaptations to atypical conditions:Chemotaxis and motility:Metabolism:General:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 130 "3,4-dihydroxy-2-butanone 4-phosphate synthase:NAD synthase:Ribosomal protein L9:Deoxycytidine deaminase:Uncharacterized flagellar protein FlaG:Flagellin and related hook-associated proteins:Flagellar capping protein:Flagellin-specific chaperone FliS:Uncharacterized conserved protein:Flagellar hook-basal body protein:Flagellar basal-body P-ring protein:Flagellar hook protein FlgE:Flagellar basal body protein:Flagellar hook capping protein:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:Uncharacterized protein conserved in bacteria:Flagellar basal body rod protein:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Riboflavin metabolism:Nicotinate and nicotinamide metabolism:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Flagellar assembly:Ribosome:General function prediction only:Function unknown:L9:fliE:fliS:ribB:nadE:FlgB:dCTP_deam:flgG_G_neg:flgE_epsilon:FlgEFG_subfam:PseB:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Energy Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:Protein synthesis:Ribosomal proteins: synthesis and modification:Cellular processes:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 131 "Glutamine amidotransferase:Protein chain release factor A:Predicted amidohydrolase:ATP-dependent Zn proteases:Fe2+/Zn2+ uptake regulation proteins:Lipid A disaccharide synthetase:Biopolymer transport protein:Zn-dependent alcohol dehydrogenases:Predicted phosphatase:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Histidine metabolism:Tryptophan metabolism:Cyanoamino acid metabolism:Lipopolysaccharide biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:prfA:lpxB:FtsH_fam:IMP_synth_hisH:ExbD_2:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Global:Metabolism:Protein synthesis:Translation factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Amino acid biosynthesis:Histidine family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 132 "Dephospho-CoA kinase:Uncharacterized conserved protein:tRNA-(guanine-N1)-methyltransferase:Di- and tricarboxylate transporters:Translation elongation factors (GTPases):ATPases involved in chromosome partitioning:ABC-type phosphate transport system, permease component:Mg2+ and Co2+ transporters:Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit:Glycyl-tRNA synthetase, beta subunit:Membrane-fusion protein:Actin-like ATPase involved in cell division:Predicted membrane GTPase involved in stress response:Preprotein translocase subunit SecG:Multiple antibiotic transporter:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Na+/H+ antiporter:Cell cycle control, cell division, chromosome partitioning:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:ABC transporters:Protein export:Bacterial secretion system:Function unknown:Signal transduction mechanisms:trmD:gatC:TIGR00152:glyS:small_GTP:YbgI_SA1388:NhaA:secG:3a0107s02c:ftsA:RND_mfp:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Protein and peptide secretion and trafficking:Protein fate:tRNA and rRNA base modification:tRNA aminoacylation:Protein synthesis:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Transport and binding proteins:Energy Metabolism:Unknown substrate:Anions:Cations and iron carrying compounds:Cellular processes:Cell division:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A" 133 "Energy production and conversion:Ketol-acid reductoisomerase:Phenylalanyl-tRNA synthetase beta subunit:Fumarase:Glutamine amidotransferase:Indole-3-glycerol phosphate synthase:Argininosuccinate lyase:Ribonucleotide reductase, beta subunit:Molybdopterin converting factor, large subunit:Membrane protease subunits, stomatin/prohibitin homologs:Preprotein translocase subunit SecD:Pyruvate kinase:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K:Integral membrane protein, interacts with FtsH:Predicted Fe-S-cluster oxidoreductase:UDP-glucose 4-epimerase:Uncharacterized membrane protein, required for N-linked glycosylation:Periplasmic protein involved in polysaccharide export:Phosphoenolpyruvate carboxykinase (ATP):Flagellar biosynthesis pathway, component FliQ:Cytochrome c553:Uncharacterized protein conserved in bacteria:Outer membrane protein/protective antigen OMA87:Uncharacterized conserved protein:Pyruvate/oxaloacetate carboxyltransferase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Galactose metabolism:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Histidine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Carbon fixation pathways in prokaryotes:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Flagellar assembly:Protein export:Bacterial secretion system:Sulfur relay system:General function prediction only:Function unknown:pckA:ilvC:pheT_bact:argH:2A0604s01:fumC_II:pyruv_kin:galE:ATP_synt_c:fliQ:IMP_synth_hisH:OM_YaeT:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Glycolysis/gluconeogenesis:TCA cycle:Sugars:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Chemotaxis and motility:Amino acid biosynthesis:Glutamate family:Pyruvate family:Histidine family:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 134 "Exopolyphosphatase:ABC-type amino acid transport system, permease component:Na+/H+ antiporter NhaD and related arsenite permeases:Primosomal protein N' (replication factor Y) - superfamily II helicase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Replication, recombination and repair:Inorganic ion transport and metabolism:Purine metabolism:Homologous recombination:Function unknown:priA:HEQRo_perm_3TM:Information storage and processing:Nucleotide Metabolism:Genetic Information Processing:Replication and Repair:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Amino acids, peptides and amines:Metabolism:Metabolism:Poorly characterized" 135 "Energy production and conversion:Isocitrate/isopropylmalate dehydrogenase:RNase P protein component:ABC-type amino acid transport system, permease component:Holliday junction resolvasome, endonuclease subunit:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type polar amino acid transport system, ATPase component:Predicted periplasmic/secreted protein:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Valine leucine and isoleucine biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Homologous recombination:Function unknown:Signal transduction mechanisms:leuB:rnpA:ruvC:HEQRo_perm_3TM:Cellular processes and signaling:Amino Acid Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:RNA processing:Transport and binding proteins:Amino acids, peptides and amines:Amino acid biosynthesis:Pyruvate family:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 136 "Glutamine amidotransferase:Preprotein translocase subunit SecA (ATPase, RNA helicase):Ribose 5-phosphate isomerase RpiB:Phosphopantetheinyl transferase (holo-ACP synthase):Membrane-fusion protein:Predicted sugar nucleotidyltransferases:Outer membrane protein:Cyclopropane fatty acid synthase and related methyltransferases:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Pentose phosphate pathway:Histidine metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Protein export:Bacterial secretion system:acpS:rpiB_lacA_lacB:secA:RND_mfp:outer_NodT:IMP_synth_hisH:Intracellular trafficking, secretion, and vesicular transport:Porins:Amino acid biosynthesis:Histidine family:Cellular processes and signaling:Metabolism:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Carbohydrate Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Unknown substrate" 137 "Energy production and conversion:F0F1-type ATP synthase, alpha subunit:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Ornithine carbamoyltransferase:Delta-aminolevulinic acid dehydratase:Enolase:Triosephosphate isomerase:Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase:Porphobilinogen deaminase:S-adenosylmethionine synthetase:Leucyl aminopeptidase:Molybdopterin converting factor, large subunit:Molecular chaperone, HSP90 family:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Ribosomal protein L19:Ribosomal protein L9:Thiamine biosynthesis protein ThiC:Enoyl-[acyl-carrier-protein] reductase (NADH):Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Putative intracellular protease/amidase:Thioredoxin-like proteins and domains:Actin-like ATPase involved in cell division:Predicted UDP-glucose 6-dehydrogenase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ATP-dependent protease HslVU (ClpYQ), ATPase subunit:Uncharacterized protein conserved in bacteria:Saccharopine dehydrogenase and related proteins:Sec-independent protein secretion pathway components:Cytochrome c peroxidase:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase:ATP-dependent protease HslVU (ClpYQ), peptidase subunit:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Fructose and mannose metabolism:Fatty acid biosynthesis:Oxidative phosphorylation:Purine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Lysine degradation:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Selenocompound metabolism:Glutathione metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Inositol phosphate metabolism:Methane metabolism:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:RNA degradation:Protein export:Bacterial secretion system:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:purC:L9:thiC:hemC:hslU:orni_carb_tr:dapA:atpA:rplS_bact:metK:eno:ftsA:DAHP_synth_II:not_thiJ:tatAE:GAPDH-I:potass_kdpF:pyruv_ox_red:NDP-sugDHase:ATP_dep_HslV:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis of cofactors, prosthetic groups, and carriers:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Other:Energy metabolism:ATP-proton motive force interconversion:Glycolysis/gluconeogenesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein folding and stabilization:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Cell division:Unknown function:General:Amino acid biosynthesis:Aromatic amino acid family:Aspartate family:Glutamate family:Metabolism:Heme, porphyrin, and cobalamin:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 138 "Glutamyl- and glutaminyl-tRNA synthetases:Imidazoleglycerol-phosphate dehydratase:Tyrosyl-tRNA synthetase:Ribosomal protein L15:Ribonucleotide reductase, beta subunit:Ribosomal protein S18:Integral membrane protein possibly involved in chromosome condensation:Putative translation initiation inhibitor, yjgF family:Ribosomal protein L35:Uroporphyrinogen-III decarboxylase:Orotate phosphoribosyltransferase:Glycosyltransferases involved in cell wall biogenesis:Uncharacterized membrane-associated protein:Single-stranded DNA-binding protein:Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily:tmRNA-binding protein:Sec-independent protein secretion pathway component TatC:Preprotein translocase subunit SecG:Outer membrane protein:Phosphoserine aminotransferase:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Histidine metabolism:Methane metabolism:Vitamin B6 metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:DNA replication:Protein export:Bacterial secretion system:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:rpmI_bact:smpB:S18:tyrS:gltX_bact:crcB:ssb:secG:tatC:rplO_bact:hisB_Nterm:serC_1:pyrE_Therm:hemE:Intracellular trafficking, secretion, and vesicular transport:Heme, porphyrin, and cobalamin:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Other:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Unknown function:General:Amino acid biosynthesis:Serine family:Histidine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 139 "Diaminopimelate decarboxylase:Imidazoleglycerol-phosphate synthase:Predicted redox protein, regulator of disulfide bond formation:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:Pseudouridylate synthases, 23S RNA-specific:Bacterial cell division membrane protein:Predicted thioesterase:dTDP-D-glucose 4,6-dehydratase:DNA-directed RNA polymerase specialized sigma subunit:Predicted transporter component:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Arginine and proline metabolism:Histidine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:RNA polymerase:Sulfur relay system:General function prediction only:Function unknown:TIGR00051:trmU:nspC:FliA_WhiG:ftsW:Poorly characterized:Amino Acid Metabolism:Genetic Information Processing:Transcription:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Central intermediary metabolism:Polyamine biosynthesis:Protein synthesis:tRNA and rRNA base modification:Cellular processes:Cell division:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 140 "Thioredoxin reductase:Phosphatidylglycerophosphate synthase:dsRNA-specific ribonuclease:Fe2+/Zn2+ uptake regulation proteins:Type II restriction enzyme, methylase subunits:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pyrimidine metabolism:Glycerophospholipid metabolism:Metabolic pathways:Secondary metabolites biosynthesis, transport and catabolism:pgsA:RNaseIII:Defense mechanisms:Information storage and processing:Lipid Metabolism:Nucleotide Metabolism:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Transcription:RNA processing:Metabolism:Cellular processes and signaling:Metabolism" 141 "Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Glutamine amidotransferase:Ribosomal protein S20:Nuclease subunit of the excinuclease complex:3-oxoacyl-[acyl-carrier-protein] synthase III:Glycosyltransferases involved in cell wall biogenesis:Zn-dependent hydrolases, including glyoxylases:Adenylylsulfate kinase and related kinases:Pseudouridylate synthases, 23S RNA-specific:6-pyruvoyl-tetrahydropterin synthase:Bacterial cell division membrane protein:Collagenase and related proteases:Type II restriction enzyme, methylase subunits:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:Flagellar biosynthesis/type III secretory pathway protein:Uncharacterized conserved protein:ABC-type metal ion transport system, periplasmic component/surface antigen:3-deoxy-D-manno-octulosonic-acid transferase:Tetraacyldisaccharide-1-P 4'-kinase:Low specificity phosphatase (HAD superfamily):Type II secretory pathway, prepilin signal peptidase PulO and related peptidases:ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Histidine metabolism:Selenocompound metabolism:Lipopolysaccharide biosynthesis:Folate biosynthesis:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Flagellar assembly:Ribosome:Bacterial secretion system:Nucleotide excision repair:General function prediction only:Function unknown:S20:TIGR00093:uvrC:purE:HAD-SF-IIIA:IMP_synth_hisH:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Enzymes of unknown specificity:Unknown function:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Membrane Transport:Environmental Information Processing:Replication and Repair:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Histidine family:Amino acid biosynthesis" 142 "Riboflavin synthase beta-chain:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Ketopantoate hydroxymethyltransferase:ATPase components of ABC transporters with duplicated ATPase domains:SAM-dependent methyltransferases:Uridylate kinase:Predicted dehydrogenase:FOG: CheY-like receiver:ABC-type polar amino acid transport system, ATPase component:Flagellar motor component:Ferritin-like protein:Flagellar basal body rod protein:Flagellar basal body-associated protein:Uncharacterized protein conserved in bacteria:DNA-directed RNA polymerase, subunit K/omega:Sec-independent protein secretion pathway components:Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component:3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Purine metabolism:Pyrimidine metabolism:Lipopolysaccharide biosynthesis:Pyruvate metabolism:Riboflavin metabolism:Pantothenate and CoA biosynthesis:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:RNA polymerase:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:lumazine-synth:panB:TIGR00302:rpoZ:KDO8P_synth:FlgC:tatAE:GAPDH-I:pyrH_bact:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Carbohydrate Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Purine ribonucleotide biosynthesis:Transcription:DNA-dependent RNA polymerase:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Riboflavin, FMN, and FAD:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 143 "Energy production and conversion:DNA primase (bacterial type):Molybdopterin biosynthesis enzymes:Fe-S oxidoreductases:Periplasmic protein TonB, links inner and outer membranes:Flagellar biosynthesis/type III secretory pathway ATPase:Flagellar biosynthesis pathway, component FlhA:ABC-type spermidine/putrescine transport systems, ATPase components:Predicted enzyme involved in methoxymalonyl-ACP biosynthesis:Amino acid transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:ABC transporters:Flagellar assembly:DNA replication:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:molyb_syn:fliI_yscN:tonB_Cterm:dnaG:FlhA:HAD-SF-IIIC:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Energy metabolism:ATP-proton motive force interconversion:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Chemotaxis and motility:Information storage and processing:Cellular processes and signaling:Genetic Information Processing" 144 "Methionine aminopeptidase:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Exopolyphosphatase:Glycosyltransferases involved in cell wall biogenesis:Zn-dependent protease with chaperone function:Na+-driven multidrug efflux pump:Uncharacterized conserved protein:Signal transduction histidine kinase:Predicted permeases:Cell wall-associated hydrolases (invasion-associated proteins):Pyridoxal phosphate biosynthesis protein:Flagellin and related hook-associated proteins:Uncharacterized conserved protein:Allophanate hydrolase subunit 2:Pyridoxal phosphate biosynthesis protein:Predicted hydrolase of the alpha/beta superfamily:Uncharacterized protein conserved in bacteria:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Methylase of polypeptide chain release factors:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Vitamin B6 metabolism:Metabolic pathways:Two-component system:Bacterial chemotaxis:Flagellar assembly:Ribosome:General function prediction only:Function unknown:Signal transduction mechanisms:tRNA_TruD_broad:met_pdase_I:hemK_fam:pdxJ:urea_amlyse_rel:matE:WbuX:Defense mechanisms:Information storage and processing:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein modification and repair:Transport and binding proteins:Other:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridoxine:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 145 "Glutamate-1-semialdehyde aminotransferase:Phenylalanyl-tRNA synthetase alpha subunit:Glutamine phosphoribosylpyrophosphate amidotransferase:Uracil phosphoribosyltransferase:Tryptophan synthase beta chain:Seryl-tRNA synthetase:FAD synthase:NAD-dependent DNA ligase (contains BRCT domain type II):Methylated DNA-protein cysteine methyltransferase:Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):ABC-type antimicrobial peptide transport system, permease component:Cystathionine beta-lyases/cystathionine gamma-synthases:Acetyl-CoA carboxylase beta subunit:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type (unclassified) transport system, ATPase component:Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase):FOG: LysM repeat:Arabinose efflux permease:ABC-type enterochelin transport system, periplasmic component:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Selenocompound metabolism:Pyruvate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Riboflavin metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Sulfur metabolism:Aminoacyl-tRNA biosynthesis:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:RNA degradation:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:hypA:trpB:serS:pheS:accD:dnlj:ogt:hemL:upp:purF:3oxo_ACP_reduc:polynuc_phos:Defense mechanisms:Membrane Transport:Environmental Information Processing:Replication and Repair:Folding Sorting and Degradation:Metabolism:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Salvage of nucleosides and nucleotides:DNA metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Protein synthesis:tRNA aminoacylation:Protein fate:Protein modification and repair:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Global" 146 "Adenylosuccinate lyase:Biotin-(acetyl-CoA carboxylase) ligase:Zn-dependent hydrolases, including glyoxylases:Preprotein translocase subunit SecA (ATPase, RNA helicase):3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:FKBP-type peptidyl-prolyl cis-trans isomerases 2:CMP-N-acetylneuraminic acid synthetase:Disulfide bond formation protein DsbB:ATPase related to the helicase subunit of the Holliday junction resolvase:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Biotin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:RNA polymerase:Protein export:Bacterial secretion system:General function prediction only:birA_ligase:purB:secA:fabZ:rpoB:Intracellular trafficking, secretion, and vesicular transport:Protein modification and repair:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Metabolism:Transcription:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Transcription:DNA-dependent RNA polymerase:Protein fate:Protein and peptide secretion and trafficking" 147 "1-acyl-sn-glycerol-3-phosphate acyltransferase:ABC-type Fe3+-hydroxamate transport system, periplasmic component:Membrane proteins related to metalloendopeptidases:Putative transcription activator:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Protein-disulfide isomerase:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Thiamine metabolism:Metabolic pathways:ABC transporters:Signal transduction mechanisms:AGP_acyltrn:Information storage and processing:Lipid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Metabolism:Cellular processes and signaling:Metabolism" 148 "3-isopropylmalate dehydratase large subunit:Phosphoglycerate dehydrogenase and related dehydrogenases:Xanthosine triphosphate pyrophosphatase:Phosphoheptose isomerase:Nucleoside-diphosphate-sugar epimerases:DNA polymerase III, alpha subunit:ABC-type molybdate transport system, periplasmic component:Fucose permease:Actin-like ATPase involved in cell morphogenesis:ABC-type Fe3+ transport system, permease component:Uncharacterized conserved protein:Uroporphyrinogen-III synthase:Predicted Rossmann fold nucleotide-binding protein:Arabinose efflux permease:Capsule polysaccharide export protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine biosynthesis:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Pyruvate metabolism:C5-Branched dibasic acid metabolism:Methane metabolism:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:TIGR00042:leuC:polc:efflux_Bcr_CflA:TIGR00730:mreB:modA:PGDH:Biosynthesis and degradation of murein sacculus and peptidoglycan:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Anions:Hypothetical proteins:Conserved:Amino acid biosynthesis:Pyruvate family:Serine family:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 149 "4-hydroxybenzoate polyprenyltransferase and related prenyltransferases:Metal-dependent proteases with possible chaperone activity:Pseudouridylate synthases, 23S RNA-specific:Organic radical activating enzymes:Signal transduction histidine kinase:6-pyruvoyl-tetrahydropterin synthase:Membrane proteins related to metalloendopeptidases:FOG: CheY-like receiver:Predicted Fe-S-cluster redox enzyme:Deoxyxylulose-5-phosphate synthase:Predicted glycosyltransferases:Uncharacterized protein conserved in bacteria:3-deoxy-D-manno-octulosonic-acid transferase:Pyrimidine reductase, riboflavin biosynthesis:Uncharacterized conserved protein:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Ubiquinone and other terpenoid-quinone biosynthesis:Lipopolysaccharide biosynthesis:Riboflavin metabolism:Folate biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00046:TIGR00048:dxs:eubact_ribD:gcp_kae1:ubiA_other:Protein fate:tRNA and rRNA base modification:Protein synthesis:Metabolism:Metabolism:Global:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Information storage and processing:Glycan Biosynthesis and Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Thiamine:Riboflavin, FMN, and FAD:Menaquinone and ubiquinone:Biosynthesis of cofactors, prosthetic groups, and carriers:Degradation of proteins, peptides, and glycopeptides" 150 "Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Predicted metal-dependent hydrolase:(acyl-carrier-protein) S-malonyltransferase:Phosphoserine phosphatase:Phosphatidylserine decarboxylase:Predicted permeases:Biopolymer transport proteins:Periplasmic component of the Tol biopolymer transport system:Phosphatidylserine synthase:Amidases related to nicotinamidase:Predicted membrane protein/domain:Uncharacterized protein related to Endonuclease III:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Fatty acid biosynthesis:Glycine serine and threonine metabolism:Glycerophospholipid metabolism:Metabolic pathways:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00043:fabD:pssA:gyrB:HAD-SF-IB:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Lipid Metabolism:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Other:Unknown function:Enzymes of unknown specificity:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 151 "Energy production and conversion:Dimethyladenosine transferase (rRNA methylation):Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:F0F1-type ATP synthase, beta subunit:Preprotein translocase subunit SecY:Ribosomal protein L35:Ribosomal protein L20:Predicted methyltransferases:Predicted metal-dependent hydrolase:(acyl-carrier-protein) S-malonyltransferase:3-oxoacyl-[acyl-carrier-protein] synthase III:F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit):ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:Fatty acid/phospholipid biosynthesis enzyme:Threonyl-tRNA synthetase:Branched-chain amino acid ABC-type transport system, permease components:Predicted hydrolase of the metallo-beta-lactamase superfamily:Predicted sugar phosphatases of the HAD superfamily:ABC-type transport system involved in cytochrome c biogenesis, permease component:Nucleoside phosphorylase:Biopolymer transport proteins:Periplasmic component of the Tol biopolymer transport system:Transcription-repair coupling factor (superfamily II helicase):ATP-dependent protease Clp, ATPase subunit:Cytochrome bd-type quinol oxidase, subunit 1:Amidases related to nicotinamidase:Low specificity phosphatase (HAD superfamily):Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Fatty acid biosynthesis:Oxidative phosphorylation:Cysteine and methionine metabolism:Lipopolysaccharide biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:ABC transporters:Ribosome:RNA degradation:Protein export:Bacterial secretion system:Nucleotide excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:rpmI_bact:TIGR00043:TIGR00096:fabD:plsX:clpX:thrS:MG423:fabH:ksgA:3a0501s007:rpmF_bact:rplT_bact:atpD:ATP_synt_epsi:HAD-SF-IIA:HAD-SF-IIIA:MTA/SAH-Nsdase:Intracellular trafficking, secretion, and vesicular transport:Environmental Information Processing:Replication and Repair:Folding Sorting and Degradation:Metabolism:Translation:Genetic Information Processing:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Lipid Metabolism:Fatty acid and phospholipid metabolism:Energy Metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:Protein synthesis:Other:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:ATP-proton motive force interconversion:Energy metabolism:Metabolism:Global:Membrane Transport" 152 "tRNA delta(2)-isopentenylpyrophosphate transferase:Anthranilate/para-aminobenzoate synthases component II:Uncharacterized conserved protein:Predicted ATPase with chaperone activity:UDP-N-acetylmuramate dehydrogenase:Nicotinic acid mononucleotide adenylyltransferase:ABC-type spermidine/putrescine transport system, permease component II:GTPase subunit of restriction endonuclease:Uncharacterized protein predicted to be involved in DNA repair:Uncharacterized proteins of the AP superfamily:Acetyltransferases, including N-acetylases of ribosomal proteins:ABC-type spermidine/putrescine transport systems, ATPase components:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyrimidine metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Nicotinate and nicotinamide metabolism:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:tRNA_TruD_broad:cyt_tran_rel:miaA:murB:TIGR00368:trpG_papA:PseH:cas1_NMENI:Defense mechanisms:Metabolism:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Nucleotide Metabolism:tRNA and rRNA base modification:Carbohydrate Metabolism:Unknown function:General:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Protein synthesis:Metabolism:Global" 153 "Energy production and conversion:Peptide methionine sulfoxide reductase:ATPases with chaperone activity, ATP-binding subunit:Lipid A disaccharide synthetase:Predicted periplasmic solute-binding protein:Uncharacterized protein required for formate dehydrogenase activity:N-terminal domain of molybdenum-binding protein:Predicted kinase related to galactokinase and mevalonate kinase:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Lipopolysaccharide biosynthesis:Metabolic pathways:General function prediction only:fdhD_narQ:lpxB:sensory_box:msrA:Cell envelope:Glycan Biosynthesis and Metabolism:Global:Metabolism:Energy metabolism:Electron transport:Regulatory functions:Small molecule interactions:Cellular processes:Adaptations to atypical conditions:Metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Poorly characterized" 154 "Energy production and conversion:Na+-dependent transporters of the SNF family:Enzyme related to GTP cyclohydrolase I:FOG: CheY-like receiver:Biopolymer transport proteins:Holliday junction resolvasome, endonuclease subunit:Outer membrane receptor proteins, mostly Fe transport:Uncharacterized protein, possibly involved in aromatic compounds catabolism:H+/citrate symporter:Cytochrome c:Uncharacterized protein conserved in bacteria:Replication, recombination and repair:Inorganic ion transport and metabolism:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:ruvC:cas2:QueF-II:Intracellular trafficking, secretion, and vesicular transport:Genetic Information Processing:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Mobile and extrachromosomal element functions:DNA replication, recombination, and repair:DNA metabolism:Replication and Repair" 155 "Imidazoleglycerol-phosphate synthase:Carbonic anhydrase:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase:GTP cyclohydrolase II:D-alanine-D-alanine ligase and related ATP-grasp enzymes:DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog:Uncharacterized protein predicted to be involved in DNA repair:Predicted membrane protein involved in D-alanine export:Flagellar hook protein FlgE:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Molybdenum cofactor biosynthesis enzyme:ABC-type tungstate transport system, periplasmic component:Amino acid transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Histidine metabolism:D-Alanine metabolism:Peptidoglycan biosynthesis:Riboflavin metabolism:Folate biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Flagellar assembly:RNA polymerase:Bacterial secretion system:Sulfur relay system:General function prediction only:taut:ribA:D_ala_D_alaTIGR:GOGAT_sm_gam:folK:rpoN_sigma:moaA:FlgEFG_subfam:cas1_NMENI:Intracellular trafficking, secretion, and vesicular transport:Riboflavin, FMN, and FAD:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Transcription factors:Transcription:Other:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Transcription:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Folic acid:Energy Metabolism:Molybdopterin" 156 "Energy production and conversion:Acetylglutamate semialdehyde dehydrogenase:Adenylosuccinate synthase:Predicted redox protein, regulator of disulfide bond formation:Fe-S-cluster-containing hydrogenase components 1:Orotate phosphoribosyltransferase:Topoisomerase IA:Predicted permeases:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Methyl-accepting chemotaxis protein:Predicted membrane protein:Flagellar motor switch protein:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Predicted transporter component:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Lysine biosynthesis:Arginine and proline metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:purA:fliG:OPT_sfam:topA_bact:pyrE_Therm:argC:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Cellular processes:Chemotaxis and motility:Amino acid biosynthesis:Glutamate family:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 157 "Arginyl-tRNA synthetase:Fructose/tagatose bisphosphate aldolase:Predicted S-adenosylmethionine-dependent methyltransferase:Conserved domain frequently associated with peptide methionine sulfoxide reductase:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Nucleotide-binding protein implicated in inhibition of septum formation:Thioredoxin reductase:Parvulin-like peptidyl-prolyl isomerase:Periplasmic protease:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Predicted nucleoside-diphosphate sugar epimerases:ABC-type phosphate transport system, ATPase component:Predicted HD superfamily hydrolase:Outer membrane protein:Aspartate racemase:Anaerobic C4-dicarboxylate transporter:Arabinose efflux permease:Putative arginyl-tRNA:protein arginylyltransferase:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Pyrimidine metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:asp_race:TIGR00091:cbbA:maf:prc:HDIG:TIGR00357:TIGR00423:argS:Dcu:3a0107s01c2:Ac_CoA_lig_AcsA:Intracellular trafficking, secretion, and vesicular transport:Hypothetical proteins:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Amino acids and amines:Glycolysis/gluconeogenesis:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein modification and repair:Transport and binding proteins:Anions:Carbohydrates, organic alcohols, and acids:Cellular processes:Cell division:Adaptations to atypical conditions:Metabolism:Conserved:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 158 "Energy production and conversion:Undecaprenyl pyrophosphate synthase:Xanthosine triphosphate pyrophosphatase:Ribosomal protein S15P/S13E:Di- and tricarboxylate transporters:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:ABC-type antimicrobial peptide transport system, permease component:Predicted PP-loop superfamily ATPase:2-methylthioadenine synthetase:ABC-type dipeptide transport system, periplasmic component:Glycyl-tRNA synthetase, alpha subunit:Uncharacterized protein conserved in bacteria:Predicted ATPase or kinase:Cation/multidrug efflux pump:4-diphosphocytidyl-2-methyl-D-erithritol synthase:Phosphatidylglycerophosphatase A and related proteins:Predicted metal-dependent hydrolase:Uncharacterized protein conserved in bacteria:Predicted transcriptional regulators:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:Carbon starvation protein, predicted membrane protein:Membrane transporters of cations and cationic drugs:Arabinose efflux permease:Uncharacterized FlgJ-related protein:Na+/H+ antiporter:Delta 1-pyrroline-5-carboxylate dehydrogenase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Glycerophospholipid metabolism:Methane metabolism:Thiamine metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Ribosome:Sulfur relay system:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00042:uppS:TIGR00089:HI0065_YjeE:ispF:TIGR00364:glyQ:NhaA:2A0602:S15_bact:Defense mechanisms:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Enzymes of unknown specificity:Unknown function:Cations and iron carrying compounds:Unknown substrate:Transport and binding proteins:Ribosomal proteins: synthesis and modification:tRNA aminoacylation:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Translation:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing" 159 "Energy production and conversion:Aspartate-semialdehyde dehydrogenase:Seryl-tRNA synthetase:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Predicted permeases:Selenocysteine synthase [seryl-tRNASer selenium transferase]:Cytochrome c:Acetyl/propionyl-CoA carboxylase, alpha subunit:Amino acid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Citrate cycle (TCA cycle):Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Selenocompound metabolism:Pyruvate metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:serS:selA:accC:asd_B:Amino acid biosynthesis:Aspartate family:Information storage and processing:Metabolism:Poorly characterized:tRNA aminoacylation:Protein synthesis:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Metabolism:Global:Translation:Genetic Information Processing:Metabolism of Other Amino Acids:Amino Acid Metabolism:Carbohydrate Metabolism" 160 "Energy production and conversion:Glutamyl- and glutaminyl-tRNA synthetases:Enolase:Translation elongation factor Ts:GTP cyclohydrolase I:Riboflavin synthase alpha chain:tRNA-(guanine-N1)-methyltransferase:F0F1-type ATP synthase, subunit a:Membrane GTPase LepA:Single-stranded DNA-specific exonuclease:Phosphoglyceromutase:Uncharacterized protein conserved in bacteria:Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit:Glycyl-tRNA synthetase, beta subunit:Transcription elongation factor:Predicted ATPase or kinase:Predicted thioesterase:Flagellar biosynthesis pathway, component FliP:Flagellin-specific chaperone FliS:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Ribosomal protein L11 methylase:Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit:ATP-dependent protease HslVU (ClpYQ), peptidase subunit:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Oxidative phosphorylation:Methane metabolism:Riboflavin metabolism:Folate biosynthesis:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Flagellar assembly:RNA degradation:Base excision repair:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00051:folE:trmD:DNA_YbaB_EbfC:tsf:gatC:HI0065_YjeE:ribE:fliS:glyS:small_GTP:gltX_bact:recJ:eno:fliP:ATP_synt_6_or_A:pgm_bpd_ind:greA:ATP_dep_HslV:Intracellular trafficking, secretion, and vesicular transport:Folic acid:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Glycolysis/gluconeogenesis:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Translation factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Chemotaxis and motility:Unknown function:Enzymes of unknown specificity:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Riboflavin, FMN, and FAD:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 161 "Diaminopimelate decarboxylase:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Type II restriction enzyme, methylase subunits:ABC-type polysaccharide/polyol phosphate transport system, ATPase component:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Metal-dependent amidase/aminoacylase/carboxypeptidase:Dihydroneopterin aldolase:Fe2+ transport system protein A:Putative multicopper oxidases:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Pyruvate metabolism:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00046:yihY_not_rbn:nspC:apt:amidohydrolases:Defense mechanisms:Poorly characterized:Metabolism:Metabolism:Cellular processes and signaling:General:Unknown function:Degradation of proteins, peptides, and glycopeptides:Protein fate:tRNA and rRNA base modification:Protein synthesis:Salvage of nucleosides and nucleotides:Purines, pyrimidines, nucleosides, and nucleotides:Polyamine biosynthesis:Central intermediary metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism" 162 "Energy production and conversion:Dihydroorotase and related cyclic amidohydrolases:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Na+-driven multidrug efflux pump:Glycine/D-amino acid oxidases (deaminating):Ni,Fe-hydrogenase maturation factor:Prolipoprotein diacylglyceryltransferase:FOG: TPR repeat, SEL1 subfamily:ABC-type transport system involved in resistance to organic solvents, ATPase component:1-aminocyclopropane-1-carboxylate deaminase:Predicted double-glycine peptidase:ABC-type sugar transport systems, ATPase components:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pyrimidine metabolism:Propanoate metabolism:Metabolic pathways:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:hydrog_prot:lgt:matE:MnmC_Cterm:Defense mechanisms:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein modification and repair:Transport and binding proteins:Other:Cellular processes and signaling:Metabolism:Poorly characterized" 163 "Ribosomal protein S7:Ribosomal protein S10:Ribosomal protein L11:Ribosomal protein L1:Ribosomal protein L23:Ribosomal protein L2:Ribosomal protein S3:Ribosomal protein L5:Ribosomal protein L6P/L9E:Ribosomal protein S5:Ribosomal protein S13:Ribosomal protein S11:Ribosomal protein S19:Ribosomal protein S17:Ribosomal protein L16/L10E:Ribosomal protein L24:Ribosomal protein L10:Transcription antiterminator:Ribosomal protein L18:Ribosomal protein S4 and related proteins:Translation, ribosomal structure and biogenesis:Transcription:Ribosome:Protein export:Bacterial secretion system:L29:L18_bact:nusG:secE_bact:rpsC_bact:rpsD_bact:rpsE_bact:rpsG_bact:rpsJ_bact:rpsS_bact:rplX_bact:rplP_bact:rplA_bact:rplB_bact:L11_bact:bact_S13:bact_S11:S17_bact:L6_bact:Translation:Information storage and processing:Protein fate:Ribosomal proteins: synthesis and modification:Protein synthesis:Transcription factors:Transcription:Genetic Information Processing:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Protein and peptide secretion and trafficking" 164 "Energy production and conversion:Dethiobiotin synthetase:Fe-S oxidoreductases:UDP-N-acetylmuramyl pentapeptide synthase:Glutamate racemase:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Outer membrane phospholipase A:Predicted double-glycine peptidase:ABC-type sugar transport systems, ATPase components:ABC-type uncharacterized transport system, permease component:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Lysine biosynthesis:D-Glutamine and D-glutamate metabolism:Peptidoglycan biosynthesis:Glycerophospholipid metabolism:Biotin metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:ABC transporters:General function prediction only:Signal transduction mechanisms:glut_race:Biosynthesis and degradation of murein sacculus and peptidoglycan:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Cell envelope:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 165 "Energy production and conversion:Mg-dependent DNase:Isopropylmalate/homocitrate/citramalate synthases:Shikimate 5-dehydrogenase:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Homoserine dehydrogenase:ATP-dependent Lon protease, bacterial type:Molybdopterin biosynthesis enzymes:Thiol-disulfide isomerase and thioredoxins:ABC-type phosphate transport system, permease component:Lipoprotein signal peptidase:Phosphopantetheinyl transferase (holo-ACP synthase):Predicted membrane protein:Type II secretory pathway, pseudopilin PulG:Sugar phosphate permease:Predicted 3'-5' exonuclease related to the exonuclease domain of PolB:Delta 1-pyrroline-5-carboxylate dehydrogenase:Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Pyruvate metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Protein export:Bacterial secretion system:Sulfur relay system:General function prediction only:Function unknown:TIGR00010:lspA:molyb_syn:aroE:acpS:TIGR00701:lon:leuA_bact:3a0107s02c:IV_pilin_GFxxxE:PseC:Intracellular trafficking, secretion, and vesicular transport:Protein fate:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Transport and binding proteins:Carbohydrate Metabolism:Anions:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aromatic amino acid family:Pyruvate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking" 166 "Energy production and conversion:Histidyl-tRNA synthetase:Tryptophanyl-tRNA synthetase:Glycerol-3-phosphate dehydrogenase:Anaerobic dehydrogenases, typically selenocysteine-containing:F0F1-type ATP synthase, subunit a:NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases:Nucleoside-diphosphate-sugar epimerases:Adenylate kinase and related kinases:NADH:ubiquinone oxidoreductase 49 kD subunit 7:NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K):3-dehydroquinate dehydratase II:NADH:ubiquinone oxidoreductase subunit 3 (chain A):Membrane-fusion protein:NADH:ubiquinone oxidoreductase 27 kD subunit:NADH:ubiquinone oxidoreductase subunit 1 (chain H):NADH:ubiquinone oxidoreductase subunit 2 (chain N):NADH:ubiquinone oxidoreductase subunit 4 (chain M):NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G):Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I):Transcription termination factor:Protein-L-isoaspartate carboxylmethyltransferase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Tryptophan metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Lipopolysaccharide biosynthesis:Glycerophospholipid metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:Function unknown:pimt:trpS:hisS:rho:aroQ:ATP_synt_6_or_A:RND_mfp:nuoB_fam:NuoC_fam:NuoD:NuoI:NDH_I_M:NDH_I_L:heptose_epim:Energy metabolism:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Translation:Genetic Information Processing:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Transcription:Carbohydrate Metabolism:Transcription factors:Protein synthesis:tRNA aminoacylation:Protein fate:Protein modification and repair:Transport and binding proteins:Unknown substrate:Amino acid biosynthesis:Aromatic amino acid family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Electron transport:ATP-proton motive force interconversion" 167 "Exopolyphosphatase:Phosphopantothenoylcysteine synthetase/decarboxylase:Aspartate carbamoyltransferase, catalytic chain:Biopolymer transport protein:ABC-type metal ion transport system, ATPase component:Predicted transcriptional regulator:Arabinose efflux permease:Uncharacterized protein conserved in bacteria:Bacterial lipocalin:Membrane-bound metallopeptidase:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:ABC transporters:Function unknown:coaBC_dfp:asp_carb_tr:Intracellular trafficking, secretion, and vesicular transport:Pantothenate and coenzyme A:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyrimidine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Poorly characterized:Nucleotide Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing" 168 "1-acyl-sn-glycerol-3-phosphate acyltransferase:Outer membrane protein:Predicted membrane protein:Peptidylarginine deiminase and related enzymes:ABC-type transport system, involved in lipoprotein release, permease component:Amino acid transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Glycerolipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:Function unknown:AGP_acyltrn:outer_NodT:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Lipid Metabolism:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Transport and binding proteins:Porins:Metabolism:Metabolism:Poorly characterized" 169 "Energy production and conversion:Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain:Uncharacterized conserved protein:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Periplasmic serine proteases (ClpP class):Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:FOG: Ankyrin repeat:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Flagellar GTP-binding protein:Cytochrome P450:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:YbgI_SA1388:hemN:SppA_dom:FGAM_synth_I:NDH_I_L:FlhF:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Unknown function:Chemotaxis and motility:Cellular processes:Degradation of proteins, peptides, and glycopeptides:Protein fate:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:General:Energy Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cellular processes and signaling:Metabolism" 170 "Energy production and conversion:Nucleoside diphosphate kinase:Aspartyl-tRNA synthetase:S-adenosylmethionine synthetase:Inorganic pyrophosphatase:Polyferredoxin:GMP synthase, PP-ATPase domain/subunit:Uridylate kinase:Adenylate kinase and related kinases:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Fe2+/Zn2+ uptake regulation proteins:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ATP-dependent protease HslVU (ClpYQ), ATPase subunit:Ferritin-like protein:Flagellar basal body rod protein:Ni,Fe-hydrogenase I small subunit:DNA-directed RNA polymerase, subunit K/omega:Cytochrome c peroxidase:Ni,Fe-hydrogenase I cytochrome b subunit:3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Lipopolysaccharide biosynthesis:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Flagellar assembly:RNA polymerase:Signal transduction mechanisms:hslU:hydA:TIGR00426:aspS_bact:rpoZ:guaA_Cterm:metK:KDO8P_synth:FlgC:pyrH_bact:CytB-hydogenase:napH_:pyruv_ox_red:Cell envelope:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Translation:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Other:Energy metabolism:Electron transport:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Purine ribonucleotide biosynthesis:Transcription:DNA-dependent RNA polymerase:Protein synthesis:tRNA aminoacylation:Protein fate:Protein folding and stabilization:Cellular processes:DNA transformation:Chemotaxis and motility:Metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism"