******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.10.0 (Release date: Wed May 21 10:35:36 2014 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= motifs/5/5.seqs.fa ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ 51345 1.0000 500 9197 1.0000 500 46577 1.0000 500 21316 1.0000 500 47890 1.0000 500 43627 1.0000 500 1372 1.0000 500 23253 1.0000 500 44334 1.0000 500 44863 1.0000 500 11843 1.0000 500 19762 1.0000 500 19835 1.0000 500 45529 1.0000 500 43819 1.0000 500 47170 1.0000 500 32775 1.0000 500 48308 1.0000 500 33639 1.0000 500 41628 1.0000 500 44925 1.0000 500 40722 1.0000 500 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme motifs/5/5.seqs.fa -oc motifs/5 -dna -minw 12 -maxw 21 -nmotifs 3 -maxsize 500000 model: mod= zoops nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 12 maxw= 21 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 2 maxsites= 22 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 global: substring= yes branching= no wbranch= no em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 11000 N= 22 strands: + sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.277 C 0.244 G 0.218 T 0.261 Background letter frequencies (from dataset with add-one prior applied): A 0.277 C 0.244 G 0.218 T 0.261 ******************************************************************************** ******************************************************************************** MOTIF 1 MEME width = 21 sites = 22 llr = 243 E-value = 6.7e-007 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A 1:315311:::111:1:143: pos.-specific C 3219::12:3::1121:5:31 probability G :81:22:3:519134::422: matrix T 6:5:4585a18:65489:429 bits 2.2 2.0 1.8 * 1.5 * * * Relative 1.3 * * * * * * Entropy 1.1 * * * * * * (16.0 bits) 0.9 * * * * ** ** * 0.7 ** * * **** ** * 0.4 ** **** ***** **** * 0.2 ******************* * 0.0 --------------------- Multilevel TGTCATTTTGTGTTTTTCTAT consensus C A TA G C GG GAC sequence C T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 40722 405 3.20e-10 TGATCTTCAT CGTCATTTTGTGTTCTTCAAT AGAACTACGA 41628 404 1.32e-09 TGATCTTCAT CGTCGTTTTGTGTTCTTCAAT AGAACTACGA 46577 163 8.48e-09 TCATAGTGTC TGTCTATATGTGTGTTTCTAT GTGACGAGAC 33639 404 5.90e-08 TGATCTCCAT CGTCGTTTTGTGTTCATCAAT AGAACTACGA 43819 219 1.74e-07 ACCGAGTGGA TGACTTTATCTGGTTTTGATT CGATAGAATT 9197 333 5.20e-07 AATCGGCCTT CGCCTGTCTGTGTGGTTATCT GCGCCTCACT 19762 399 1.16e-06 GAAACACACA TCACATTTTGTGGTTTTGGGC ACAGACGATC 44334 266 1.86e-06 TGTAAATATG TCACAGTTTGTGGTGTTCGAC AATTAGTGAT 1372 410 1.86e-06 AGATCCGCGG CGTCAATCTCGGCGGTTGGAT GGTGCTGGAA 43627 246 2.23e-06 AAAAGTTAAC CGGCAATGTGTATCGTTGACT TGTGCCGCAG 51345 202 2.44e-06 GCTTGTGCTT TGCCAGTGACTGTGGTTGTGT GAGTCCCCCT 44925 124 2.67e-06 TCCCAACTCA TCTCGATGTCTGTGTTTCTGA AATGAGAAGA 19835 239 2.92e-06 TTGTGTGGCG TGTTTTTGTGTGAGTTTATGT TGACCACAAA 48308 323 5.33e-06 CAGAGGCTGA TGGCTTTTTCTGCAGCTAATT CTATCAGGCA 21316 373 6.83e-06 CATTGATCGT TGTCTTCCTTTGTTCTACTTT TTGTGACAAT 44863 145 7.41e-06 AACATAGGAC AGACATATTGTGAATTTGGAT GGACGACAGA 11843 250 8.03e-06 GCTGCCGCCA TGGCTTTTTCGGTTTTCTTCT TTCAGCAACA 45529 268 1.10e-05 TCTAGAGCCA TCACTTCGTAGGTTTTTCATT TCTTTCGCAC 32775 170 2.32e-05 CATCATTATC AGTCAGTTTTTGCACCTGTTT ATAGGCAAAA 47170 278 3.78e-05 GGTAAGGTTT TGAAATTTTGAATTGTTCCCT GCGTGCAAAT 23253 375 6.39e-05 CTCGTACAGT TGTCGACCTCCGTCTATCACT CCTCACAAGT 47890 276 1.18e-04 TTTTGTAACA AGTAAAAGTGTCTTGCTGTCT GTCACGAGTG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 40722 3.2e-10 404_[+1]_75 41628 1.3e-09 403_[+1]_76 46577 8.5e-09 162_[+1]_317 33639 5.9e-08 403_[+1]_76 43819 1.7e-07 218_[+1]_261 9197 5.2e-07 332_[+1]_147 19762 1.2e-06 398_[+1]_81 44334 1.9e-06 265_[+1]_214 1372 1.9e-06 409_[+1]_70 43627 2.2e-06 245_[+1]_234 51345 2.4e-06 201_[+1]_278 44925 2.7e-06 123_[+1]_356 19835 2.9e-06 238_[+1]_241 48308 5.3e-06 322_[+1]_157 21316 6.8e-06 372_[+1]_107 44863 7.4e-06 144_[+1]_335 11843 8e-06 249_[+1]_230 45529 1.1e-05 267_[+1]_212 32775 2.3e-05 169_[+1]_310 47170 3.8e-05 277_[+1]_202 23253 6.4e-05 374_[+1]_105 47890 0.00012 275_[+1]_204 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=21 seqs=22 40722 ( 405) CGTCATTTTGTGTTCTTCAAT 1 41628 ( 404) CGTCGTTTTGTGTTCTTCAAT 1 46577 ( 163) TGTCTATATGTGTGTTTCTAT 1 33639 ( 404) CGTCGTTTTGTGTTCATCAAT 1 43819 ( 219) TGACTTTATCTGGTTTTGATT 1 9197 ( 333) CGCCTGTCTGTGTGGTTATCT 1 19762 ( 399) TCACATTTTGTGGTTTTGGGC 1 44334 ( 266) TCACAGTTTGTGGTGTTCGAC 1 1372 ( 410) CGTCAATCTCGGCGGTTGGAT 1 43627 ( 246) CGGCAATGTGTATCGTTGACT 1 51345 ( 202) TGCCAGTGACTGTGGTTGTGT 1 44925 ( 124) TCTCGATGTCTGTGTTTCTGA 1 19835 ( 239) TGTTTTTGTGTGAGTTTATGT 1 48308 ( 323) TGGCTTTTTCTGCAGCTAATT 1 21316 ( 373) TGTCTTCCTTTGTTCTACTTT 1 44863 ( 145) AGACATATTGTGAATTTGGAT 1 11843 ( 250) TGGCTTTTTCGGTTTTCTTCT 1 45529 ( 268) TCACTTCGTAGGTTTTTCATT 1 32775 ( 170) AGTCAGTTTTTGCACCTGTTT 1 47170 ( 278) TGAAATTTTGAATTGTTCCCT 1 23253 ( 375) TGTCGACCTCCGTCTATCACT 1 47890 ( 276) AGTAAAAGTGTCTTGCTGTCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 10560 bayes= 8.90388 E= 6.7e-007 -102 16 -1110 118 -1110 -43 191 -1110 -2 -142 -67 94 -161 182 -1110 -252 71 -1110 -26 48 -2 -1110 -26 106 -161 -84 -1110 157 -161 -43 33 80 -261 -1110 -1110 187 -261 38 133 -152 -261 -242 -67 157 -161 -242 199 -1110 -161 -84 -67 129 -102 -142 33 94 -1110 -10 74 65 -161 -84 -1110 157 -261 -242 -1110 180 -102 90 74 -252 39 -242 -26 65 20 16 -26 -20 -261 -142 -1110 173 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 22 E= 6.7e-007 0.136364 0.272727 0.000000 0.590909 0.000000 0.181818 0.818182 0.000000 0.272727 0.090909 0.136364 0.500000 0.090909 0.863636 0.000000 0.045455 0.454545 0.000000 0.181818 0.363636 0.272727 0.000000 0.181818 0.545455 0.090909 0.136364 0.000000 0.772727 0.090909 0.181818 0.272727 0.454545 0.045455 0.000000 0.000000 0.954545 0.045455 0.318182 0.545455 0.090909 0.045455 0.045455 0.136364 0.772727 0.090909 0.045455 0.863636 0.000000 0.090909 0.136364 0.136364 0.636364 0.136364 0.090909 0.272727 0.500000 0.000000 0.227273 0.363636 0.409091 0.090909 0.136364 0.000000 0.772727 0.045455 0.045455 0.000000 0.909091 0.136364 0.454545 0.363636 0.045455 0.363636 0.045455 0.181818 0.409091 0.318182 0.272727 0.181818 0.227273 0.045455 0.090909 0.000000 0.863636 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- [TC]G[TA]C[AT][TA]T[TG]T[GC]TGT[TG][TGC]TT[CG][TA][ACT]T -------------------------------------------------------------------------------- Time 4.07 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 MEME width = 21 sites = 7 llr = 137 E-value = 1.7e-005 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A :::7::3:1:::4::aa:1:: pos.-specific C ::9::911::19416::7:1: probability G :1::::4:::::1:3::::94 matrix T a913a1199a91:91::39:6 bits 2.2 2.0 * * * 1.8 * * * ** 1.5 * * * ** * Relative 1.3 *** ** ***** * ** ** Entropy 1.1 ****** ***** * ****** (28.2 bits) 0.9 ****** ***** * ****** 0.7 ****** ***** ******** 0.4 ****** ************** 0.2 ********************* 0.0 --------------------- Multilevel TTCATCGTTTTCATCAACTGT consensus T A C G T G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 40722 375 3.13e-13 ATCTTCGTAG TTCATCGTTTTCCTCAACTGT GATCTTCATC 41628 374 3.13e-13 ATCTTCGTAG TTCATCGTTTTCCTCAACTGT GATCTTCATC 33639 374 1.90e-12 ATCTTCGTAG TTCATCATTTTCCTCAACTGT GATCTCCATC 51345 53 3.04e-09 ACTTGCTTTA TTTTTCATTTTTATGAACTGG CAATATTGAG 19762 137 6.31e-09 ACAAAGTAGC TTCATTGTTTTCACGAATAGT TAGCAGATAG 48308 185 6.99e-09 TTTGAGAAGT TGCATCTTTTCCATTAATTGG TTTACTATCT 23253 348 1.58e-08 CTGGCTAGCG TTCTTCCCATTCGTCAACTCG TACAGTTGTC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 40722 3.1e-13 374_[+2]_105 41628 3.1e-13 373_[+2]_106 33639 1.9e-12 373_[+2]_106 51345 3e-09 52_[+2]_427 19762 6.3e-09 136_[+2]_343 48308 7e-09 184_[+2]_295 23253 1.6e-08 347_[+2]_132 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=21 seqs=7 40722 ( 375) TTCATCGTTTTCCTCAACTGT 1 41628 ( 374) TTCATCGTTTTCCTCAACTGT 1 33639 ( 374) TTCATCATTTTCCTCAACTGT 1 51345 ( 53) TTTTTCATTTTTATGAACTGG 1 19762 ( 137) TTCATTGTTTTCACGAATAGT 1 48308 ( 185) TGCATCTTTTCCATTAATTGG 1 23253 ( 348) TTCTTCCCATTCGTCAACTCG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 10560 bayes= 10.4018 E= 1.7e-005 -945 -945 -945 194 -945 -945 -61 171 -945 181 -945 -87 136 -945 -945 13 -945 -945 -945 194 -945 181 -945 -87 4 -77 98 -87 -945 -77 -945 171 -95 -945 -945 171 -945 -945 -945 194 -945 -77 -945 171 -945 181 -945 -87 63 81 -61 -945 -945 -77 -945 171 -945 123 39 -87 185 -945 -945 -945 185 -945 -945 -945 -945 155 -945 13 -95 -945 -945 171 -945 -77 198 -945 -945 -945 98 113 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 7 E= 1.7e-005 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.142857 0.857143 0.000000 0.857143 0.000000 0.142857 0.714286 0.000000 0.000000 0.285714 0.000000 0.000000 0.000000 1.000000 0.000000 0.857143 0.000000 0.142857 0.285714 0.142857 0.428571 0.142857 0.000000 0.142857 0.000000 0.857143 0.142857 0.000000 0.000000 0.857143 0.000000 0.000000 0.000000 1.000000 0.000000 0.142857 0.000000 0.857143 0.000000 0.857143 0.000000 0.142857 0.428571 0.428571 0.142857 0.000000 0.000000 0.142857 0.000000 0.857143 0.000000 0.571429 0.285714 0.142857 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.714286 0.000000 0.285714 0.142857 0.000000 0.000000 0.857143 0.000000 0.142857 0.857143 0.000000 0.000000 0.000000 0.428571 0.571429 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- TTC[AT]TC[GA]TTTTC[AC]T[CG]AA[CT]TG[TG] -------------------------------------------------------------------------------- Time 8.04 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 MEME width = 21 sites = 5 llr = 117 E-value = 7.3e-005 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A aa::a:88::::::a2:a:aa pos.-specific C :::::8::a::8:8:66:::: probability G ::8a:::2:a:::2:24:6:: matrix T ::2::22:::a2a:::::4:: bits 2.2 * * 2.0 * *** * 1.8 ** ** *** * * * ** 1.5 ** ** *** * * * ** Relative 1.3 ****** ******* * ** Entropy 1.1 *************** ***** (33.9 bits) 0.9 *************** ***** 0.7 ********************* 0.4 ********************* 0.2 ********************* 0.0 --------------------- Multilevel AAGGACAACGTCTCACCAGAA consensus T TTG T G AG T sequence G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 40722 240 3.12e-13 AACTCCTGGT AAGGACAACGTCTCACCAGAA GTTCAATCGC 41628 239 3.12e-13 AACTCCTAGT AAGGACAACGTCTCACCAGAA GTTCAATCGC 33639 239 3.12e-13 CGCCCCTGGT AAGGACAACGTCTCACCAGAA GTTCAATCGC 19762 202 4.31e-11 ATCCCAAAGA AAGGACAACGTTTCAAGATAA CGTGAGGAAG 23253 40 3.38e-10 TCGTAGTTTA AATGATTGCGTCTGAGGATAA AAGTGCCGGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 40722 3.1e-13 239_[+3]_240 41628 3.1e-13 238_[+3]_241 33639 3.1e-13 238_[+3]_241 19762 4.3e-11 201_[+3]_278 23253 3.4e-10 39_[+3]_440 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=21 seqs=5 40722 ( 240) AAGGACAACGTCTCACCAGAA 1 41628 ( 239) AAGGACAACGTCTCACCAGAA 1 33639 ( 239) AAGGACAACGTCTCACCAGAA 1 19762 ( 202) AAGGACAACGTTTCAAGATAA 1 23253 ( 40) AATGATTGCGTCTGAGGATAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 10560 bayes= 11.2954 E= 7.3e-005 185 -897 -897 -897 185 -897 -897 -897 -897 -897 188 -38 -897 -897 220 -897 185 -897 -897 -897 -897 171 -897 -38 153 -897 -897 -38 153 -897 -12 -897 -897 203 -897 -897 -897 -897 220 -897 -897 -897 -897 194 -897 171 -897 -38 -897 -897 -897 194 -897 171 -12 -897 185 -897 -897 -897 -47 130 -12 -897 -897 130 88 -897 185 -897 -897 -897 -897 -897 146 62 185 -897 -897 -897 185 -897 -897 -897 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 5 E= 7.3e-005 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.800000 0.200000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.800000 0.000000 0.200000 0.800000 0.000000 0.000000 0.200000 0.800000 0.000000 0.200000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.800000 0.000000 0.200000 0.000000 0.000000 0.000000 1.000000 0.000000 0.800000 0.200000 0.000000 1.000000 0.000000 0.000000 0.000000 0.200000 0.600000 0.200000 0.000000 0.000000 0.600000 0.400000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.600000 0.400000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- AA[GT]GA[CT][AT][AG]CGT[CT]T[CG]A[CAG][CG]A[GT]AA -------------------------------------------------------------------------------- Time 12.01 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 51345 4.82e-08 52_[+2(3.04e-09)]_128_\ [+1(2.44e-06)]_278 9197 1.48e-03 332_[+1(5.20e-07)]_147 46577 1.91e-05 162_[+1(8.48e-09)]_317 21316 2.72e-02 372_[+1(6.83e-06)]_107 47890 1.28e-01 500 43627 6.11e-03 245_[+1(2.23e-06)]_234 1372 1.88e-02 409_[+1(1.86e-06)]_70 23253 1.90e-11 39_[+3(3.38e-10)]_287_\ [+2(1.58e-08)]_6_[+1(6.39e-05)]_105 44334 1.63e-02 140_[+1(5.62e-05)]_104_\ [+1(1.86e-06)]_214 44863 2.64e-02 144_[+1(7.41e-06)]_335 11843 3.16e-03 249_[+1(8.03e-06)]_230 19762 2.64e-14 136_[+2(6.31e-09)]_44_\ [+3(4.31e-11)]_176_[+1(1.16e-06)]_81 19835 1.51e-02 238_[+1(2.92e-06)]_241 45529 7.68e-03 267_[+1(1.10e-05)]_15_\ [+3(8.16e-05)]_176 43819 1.59e-03 218_[+1(1.74e-07)]_261 47170 9.44e-02 277_[+1(3.78e-05)]_202 32775 8.35e-03 169_[+1(2.32e-05)]_310 48308 1.29e-06 184_[+2(6.99e-09)]_117_\ [+1(5.33e-06)]_157 33639 5.83e-21 238_[+3(3.12e-13)]_114_\ [+2(1.90e-12)]_9_[+1(5.90e-08)]_76 41628 2.61e-23 136_[+1(6.81e-05)]_81_\ [+3(3.12e-13)]_114_[+2(3.13e-13)]_9_[+1(1.32e-09)]_76 44925 2.00e-02 10_[+1(7.72e-05)]_92_[+1(2.67e-06)]_\ 356 40722 6.61e-24 239_[+3(3.12e-13)]_114_\ [+2(3.13e-13)]_9_[+1(3.20e-10)]_75 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 3 reached. ******************************************************************************** CPU: seaotter.hsd1.wa.comcast.net ********************************************************************************