******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.10.0 (Release date: Wed May 21 10:35:36 2014 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= motifs/203/203.seqs.fa ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ 13427 1.0000 500 20804 1.0000 500 21069 1.0000 500 22213 1.0000 500 22565 1.0000 500 2272 1.0000 500 23850 1.0000 500 25753 1.0000 500 262960 1.0000 500 263799 1.0000 500 269540 1.0000 500 270138 1.0000 500 27377 1.0000 500 3038 1.0000 500 33859 1.0000 500 5952 1.0000 500 5993 1.0000 500 6489 1.0000 500 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme motifs/203/203.seqs.fa -oc motifs/203 -dna -minw 12 -maxw 21 -nmotifs 3 -maxsize 500000 model: mod= zoops nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 12 maxw= 21 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 2 maxsites= 18 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 global: substring= yes branching= no wbranch= no em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 9000 N= 18 strands: + sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.260 C 0.244 G 0.237 T 0.260 Background letter frequencies (from dataset with add-one prior applied): A 0.260 C 0.244 G 0.237 T 0.260 ******************************************************************************** ******************************************************************************** MOTIF 1 MEME width = 16 sites = 18 llr = 191 E-value = 5.1e-004 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A 37631:83:9:45276 pos.-specific C 7127391:a:663724 probability G 12::1:::::3121:: matrix T :12:6117:12::111 bits 2.1 * 1.9 * 1.7 ** 1.5 * ** Relative 1.2 ** ** Entropy 1.0 * ***** (15.3 bits) 0.8 * * ***** * ** 0.6 **** ******* *** 0.4 **************** 0.2 **************** 0.0 ---------------- Multilevel CAACTCATCACCACAA consensus AGCAC A GACACC sequence G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ---------------- 270138 276 1.15e-08 CAACCACAAC CAACCCATCACAACAC TCCCAACCCA 33859 453 8.08e-08 GCTCTATCAT AAACTCATCAGCGCAA AACAATATCA 262960 212 1.46e-07 GTGTCCTCTA CAAATCATCACCGCCA CAGACCACCT 269540 158 1.69e-07 ATTAGTGCAT CAACTCATCATCAAAC ACCCACAAAG 27377 478 2.54e-07 GCCTGCCCAT CGCCCCATCACCACAC GTATCTC 25753 460 3.77e-07 AAAACGAATC CAACCCATCAGCCAAC AATCCAATCC 22213 475 9.82e-07 ACCAATCCAA CAACTCAACACCCTAA CAACATCAAT 22565 377 3.09e-06 GGCGTTTTGT CGTCGCATCACAACAA CAAAAAAAGA 263799 458 5.87e-06 AACCAACACC AACCACAACACCACCA GACCGACACA 5993 440 6.40e-06 AAGATCATCA AGAATCTTCACAACAA ATAGGCAAGG 2272 475 6.40e-06 ACGCCCATCA CAACTCAACATCACCT CTCACCATCT 21069 473 1.24e-05 AATCCACCAT CCAATCCACACAACAA CAAATCTTCA 3038 481 1.34e-05 TCGTCGAAAG CAACTTCTCACACAAC AACC 23850 262 2.58e-05 CACTTCCAGT GGTACCATCAGCCCAA ATGTTTTGAC 6489 141 3.37e-05 ATGATCTTTA CAACCTATCACAGATA GCTAACTGTG 5952 25 3.37e-05 AATCTGGGTG CACAACATCTGCCCAC TTCAACTGCC 20804 220 6.26e-05 ACTGTTTGAG AATATCATCAGGAGAC TTGTACGGCT 13427 342 7.85e-05 TTCTTCTACG ATCCTCAACATAGCCA CTGGTTCGGT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 270138 1.1e-08 275_[+1]_209 33859 8.1e-08 452_[+1]_32 262960 1.5e-07 211_[+1]_273 269540 1.7e-07 157_[+1]_327 27377 2.5e-07 477_[+1]_7 25753 3.8e-07 459_[+1]_25 22213 9.8e-07 474_[+1]_10 22565 3.1e-06 376_[+1]_108 263799 5.9e-06 457_[+1]_27 5993 6.4e-06 439_[+1]_45 2272 6.4e-06 474_[+1]_10 21069 1.2e-05 472_[+1]_12 3038 1.3e-05 480_[+1]_4 23850 2.6e-05 261_[+1]_223 6489 3.4e-05 140_[+1]_344 5952 3.4e-05 24_[+1]_460 20804 6.3e-05 219_[+1]_265 13427 7.8e-05 341_[+1]_143 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=16 seqs=18 270138 ( 276) CAACCCATCACAACAC 1 33859 ( 453) AAACTCATCAGCGCAA 1 262960 ( 212) CAAATCATCACCGCCA 1 269540 ( 158) CAACTCATCATCAAAC 1 27377 ( 478) CGCCCCATCACCACAC 1 25753 ( 460) CAACCCATCAGCCAAC 1 22213 ( 475) CAACTCAACACCCTAA 1 22565 ( 377) CGTCGCATCACAACAA 1 263799 ( 458) AACCACAACACCACCA 1 5993 ( 440) AGAATCTTCACAACAA 1 2272 ( 475) CAACTCAACATCACCT 1 21069 ( 473) CCAATCCACACAACAA 1 3038 ( 481) CAACTTCTCACACAAC 1 23850 ( 262) GGTACCATCAGCCCAA 1 6489 ( 141) CAACCTATCACAGATA 1 5952 ( 25) CACAACATCTGCCCAC 1 20804 ( 220) AATATCATCAGGAGAC 1 13427 ( 342) ATCCTCAACATAGCCA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 16 n= 8730 bayes= 8.91886 E= 5.1e-004 10 145 -209 -1081 136 -213 -9 -222 123 -13 -1081 -64 36 145 -1081 -1081 -122 19 -209 110 -1081 187 -1081 -122 168 -113 -1081 -222 10 -1081 -1081 147 -1081 204 -1081 -1081 186 -1081 -1081 -222 -1081 119 23 -64 58 119 -209 -1081 95 19 -9 -1081 -22 145 -209 -222 148 -13 -1081 -222 110 67 -1081 -222 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 16 nsites= 18 E= 5.1e-004 0.277778 0.666667 0.055556 0.000000 0.666667 0.055556 0.222222 0.055556 0.611111 0.222222 0.000000 0.166667 0.333333 0.666667 0.000000 0.000000 0.111111 0.277778 0.055556 0.555556 0.000000 0.888889 0.000000 0.111111 0.833333 0.111111 0.000000 0.055556 0.277778 0.000000 0.000000 0.722222 0.000000 1.000000 0.000000 0.000000 0.944444 0.000000 0.000000 0.055556 0.000000 0.555556 0.277778 0.166667 0.388889 0.555556 0.055556 0.000000 0.500000 0.277778 0.222222 0.000000 0.222222 0.666667 0.055556 0.055556 0.722222 0.222222 0.000000 0.055556 0.555556 0.388889 0.000000 0.055556 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- [CA][AG][AC][CA][TC]CA[TA]CA[CG][CA][ACG][CA][AC][AC] -------------------------------------------------------------------------------- Time 3.10 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 MEME width = 12 sites = 13 llr = 135 E-value = 1.2e+000 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A :183:72::538 pos.-specific C ::::::5:1:3: probability G a927a3:a9311 matrix T ::1:::4::232 bits 2.1 * * * 1.9 * * * 1.7 ** * ** 1.5 ** * ** Relative 1.2 ** ** ** Entropy 1.0 ****** ** * (15.0 bits) 0.8 ****** ** * 0.6 ********** * 0.4 ********** * 0.2 ************ 0.0 ------------ Multilevel GGAGGACGGAAA consensus A GT GC sequence T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ------------ 6489 444 4.82e-08 ACAGACAGAC GGAGGACGGACA GAGACGACGA 5952 327 1.47e-06 GACTTATGGC GGAGGGCGGGCA GATGTTGCTT 33859 195 1.47e-06 TCTTCTTCGT GGAGGAAGGATA CAGTTGCCTT 27377 314 1.47e-06 AGTCCAAGAA GGAAGATGGATA CAATAATGTA 20804 162 2.64e-06 CATTAGCCGA GGAGGAAGGGCA ACAGCAGTTT 269540 129 5.99e-06 GCCAGTCCGA GGAGGATGGACG AATGCAAATT 25753 416 9.67e-06 GCTTTTCGTT GGGGGACGGTAA GCGCCGACGA 3038 55 1.19e-05 ACTGGCTTTC GGTGGGCGGATA TGCAGATGAA 13427 161 1.51e-05 ATTGCCGGGA GGAAGATGGGTT GATGGTGATG 262960 289 1.74e-05 TCAGATCGTT GGAAGACGGTGA AGACAGTATC 263799 294 2.15e-05 AGGCAGATGT GAAAGATGGAAA CGATACCGCC 23850 174 2.42e-05 TGGTCAGGTG GGGGGGCGGAAT CATGAGTCGA 22213 328 2.60e-05 CAAAAGAGAG GGAGGGTGCGAA CGCATATATG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 6489 4.8e-08 443_[+2]_45 5952 1.5e-06 326_[+2]_162 33859 1.5e-06 194_[+2]_294 27377 1.5e-06 313_[+2]_175 20804 2.6e-06 161_[+2]_327 269540 6e-06 128_[+2]_360 25753 9.7e-06 415_[+2]_73 3038 1.2e-05 54_[+2]_434 13427 1.5e-05 160_[+2]_328 262960 1.7e-05 288_[+2]_200 263799 2.2e-05 293_[+2]_195 23850 2.4e-05 173_[+2]_315 22213 2.6e-05 327_[+2]_161 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=12 seqs=13 6489 ( 444) GGAGGACGGACA 1 5952 ( 327) GGAGGGCGGGCA 1 33859 ( 195) GGAGGAAGGATA 1 27377 ( 314) GGAAGATGGATA 1 20804 ( 162) GGAGGAAGGGCA 1 269540 ( 129) GGAGGATGGACG 1 25753 ( 416) GGGGGACGGTAA 1 3038 ( 55) GGTGGGCGGATA 1 13427 ( 161) GGAAGATGGGTT 1 262960 ( 289) GGAAGACGGTGA 1 263799 ( 294) GAAAGATGGAAA 1 23850 ( 174) GGGGGGCGGAAT 1 22213 ( 328) GGAGGGTGCGAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 8802 bayes= 9.93221 E= 1.2e+000 -1035 -1035 208 -1035 -175 -1035 196 -1035 157 -1035 -62 -175 25 -1035 155 -1035 -1035 -1035 208 -1035 141 -1035 38 -1035 -75 92 -1035 57 -1035 -1035 208 -1035 -1035 -166 196 -1035 105 -1035 38 -76 25 34 -162 24 157 -1035 -162 -76 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 13 E= 1.2e+000 0.000000 0.000000 1.000000 0.000000 0.076923 0.000000 0.923077 0.000000 0.769231 0.000000 0.153846 0.076923 0.307692 0.000000 0.692308 0.000000 0.000000 0.000000 1.000000 0.000000 0.692308 0.000000 0.307692 0.000000 0.153846 0.461538 0.000000 0.384615 0.000000 0.000000 1.000000 0.000000 0.000000 0.076923 0.923077 0.000000 0.538462 0.000000 0.307692 0.153846 0.307692 0.307692 0.076923 0.307692 0.769231 0.000000 0.076923 0.153846 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- GGA[GA]G[AG][CT]GG[AG][ACT]A -------------------------------------------------------------------------------- Time 5.82 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 MEME width = 12 sites = 18 llr = 162 E-value = 1.3e+000 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A ::1:1121::1: pos.-specific C ::41:3411122 probability G :a::9235::66 matrix T a:6914249922 bits 2.1 * 1.9 ** 1.7 ** * * 1.5 ** ** ** Relative 1.2 ** ** ** Entropy 1.0 ** ** ** (13.0 bits) 0.8 ***** ** 0.6 ***** *** * 0.4 ***** ***** 0.2 ************ 0.0 ------------ Multilevel TGTTGTCGTTGG consensus C CGT C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ------------ 5993 4 1.64e-07 TGC TGTTGTGGTTGG TCGGGGTGTT 3038 392 2.79e-07 TGGAATTTAC TGTTGCCGTTGG CACAAGGCTC 262960 30 9.41e-07 CTGTTTACTT TGTTGTCGTTGC GATGAGCTAT 263799 56 1.62e-06 GTGTCATCGT TGTTGTTTTTGG GAACTTGTGG 23850 67 3.05e-06 ATTTTACTGT TGCTGCTGTTGG TCCTCGTGAG 22213 30 4.03e-06 AAAGTGGATT TGTTGACTTTGG TACGACGATG 33859 226 1.15e-05 TGTAGCTTGT TGTTGCAGTTCG TTGCAGCAGA 269540 75 1.70e-05 TACACACCTA TGTTGTCTTTCT CTTCTTAACG 13427 269 2.09e-05 CGCCGAGGTA TGTTGGTGTTTG ATAACTCTGC 22565 209 3.51e-05 TCGTCGTTCA TGCTGTGTTCGG TGCGTTCGTG 2272 40 4.47e-05 GGGTGTGGTG TGCTGTGGTTAC TGTGTTGAGT 20804 285 5.62e-05 CACGTTGGTG TGATGTGTTTGT GTTGATCTAA 21069 385 7.64e-05 AAGTAATCTT TGCTGTAGCTTG CTCCTTGCTC 6489 46 1.40e-04 ATGGCTTGTT TGCTGCCGCTCT TTCCGGCTCT 27377 271 1.40e-04 GATTTGTACT TGCTAGCTTTGC TTAAAGAGCT 5952 129 1.58e-04 TCATTAGTAA TGTTGAACTTGC GTCTTGATGA 270138 382 1.77e-04 GTCACGGGAG TGCCGCCATTGG CTCCGCCCTC 25753 138 1.77e-04 GATTTGAAGG TGTTTGGTTTTG ATAGTCCATA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 5993 1.6e-07 3_[+3]_485 3038 2.8e-07 391_[+3]_97 262960 9.4e-07 29_[+3]_459 263799 1.6e-06 55_[+3]_433 23850 3.1e-06 66_[+3]_422 22213 4e-06 29_[+3]_459 33859 1.1e-05 225_[+3]_263 269540 1.7e-05 74_[+3]_414 13427 2.1e-05 268_[+3]_220 22565 3.5e-05 208_[+3]_280 2272 4.5e-05 39_[+3]_449 20804 5.6e-05 284_[+3]_204 21069 7.6e-05 384_[+3]_104 6489 0.00014 45_[+3]_443 27377 0.00014 270_[+3]_218 5952 0.00016 128_[+3]_360 270138 0.00018 381_[+3]_107 25753 0.00018 137_[+3]_351 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=12 seqs=18 5993 ( 4) TGTTGTGGTTGG 1 3038 ( 392) TGTTGCCGTTGG 1 262960 ( 30) TGTTGTCGTTGC 1 263799 ( 56) TGTTGTTTTTGG 1 23850 ( 67) TGCTGCTGTTGG 1 22213 ( 30) TGTTGACTTTGG 1 33859 ( 226) TGTTGCAGTTCG 1 269540 ( 75) TGTTGTCTTTCT 1 13427 ( 269) TGTTGGTGTTTG 1 22565 ( 209) TGCTGTGTTCGG 1 2272 ( 40) TGCTGTGGTTAC 1 20804 ( 285) TGATGTGTTTGT 1 21069 ( 385) TGCTGTAGCTTG 1 6489 ( 46) TGCTGCCGCTCT 1 27377 ( 271) TGCTAGCTTTGC 1 5952 ( 129) TGTTGAACTTGC 1 270138 ( 382) TGCCGCCATTGG 1 25753 ( 138) TGTTTGGTTTTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 8802 bayes= 9.0653 E= 1.3e+000 -1081 -1081 -1081 194 -1081 -1081 208 -1081 -222 67 -1081 110 -1081 -213 -1081 186 -222 -1081 191 -222 -122 19 -51 77 -64 67 23 -64 -222 -213 108 58 -1081 -113 -1081 177 -1081 -213 -1081 186 -222 -55 137 -64 -1081 -13 137 -64 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 18 E= 1.3e+000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.055556 0.388889 0.000000 0.555556 0.000000 0.055556 0.000000 0.944444 0.055556 0.000000 0.888889 0.055556 0.111111 0.277778 0.166667 0.444444 0.166667 0.388889 0.277778 0.166667 0.055556 0.055556 0.500000 0.388889 0.000000 0.111111 0.000000 0.888889 0.000000 0.055556 0.000000 0.944444 0.055556 0.166667 0.611111 0.166667 0.000000 0.222222 0.611111 0.166667 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- TG[TC]TG[TC][CG][GT]TTG[GC] -------------------------------------------------------------------------------- Time 8.66 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 13427 2.67e-04 160_[+2(1.51e-05)]_96_\ [+3(2.09e-05)]_61_[+1(7.85e-05)]_143 20804 1.14e-04 161_[+2(2.64e-06)]_46_\ [+1(6.26e-05)]_49_[+3(5.62e-05)]_204 21069 4.82e-03 384_[+3(7.64e-05)]_76_\ [+1(1.24e-05)]_12 22213 2.20e-06 29_[+3(4.03e-06)]_286_\ [+2(2.60e-05)]_112_[+1(7.02e-05)]_7_[+1(9.82e-07)]_10 22565 1.10e-03 208_[+3(3.51e-05)]_156_\ [+1(3.09e-06)]_108 2272 2.65e-03 39_[+3(4.47e-05)]_423_\ [+1(6.40e-06)]_10 23850 2.92e-05 66_[+3(3.05e-06)]_95_[+2(2.42e-05)]_\ 76_[+1(2.58e-05)]_223 25753 1.09e-05 415_[+2(9.67e-06)]_32_\ [+1(3.77e-07)]_25 262960 7.34e-08 29_[+3(9.41e-07)]_170_\ [+1(1.46e-07)]_61_[+2(1.74e-05)]_200 263799 4.07e-06 55_[+3(1.62e-06)]_226_\ [+2(2.15e-05)]_152_[+1(5.87e-06)]_27 269540 4.41e-07 74_[+3(1.70e-05)]_42_[+2(5.99e-06)]_\ 17_[+1(1.69e-07)]_327 270138 4.77e-05 275_[+1(1.15e-08)]_209 27377 1.17e-06 313_[+2(1.47e-06)]_152_\ [+1(2.54e-07)]_7 3038 1.04e-06 54_[+2(1.19e-05)]_325_\ [+3(2.79e-07)]_77_[+1(1.34e-05)]_4 33859 4.39e-08 194_[+2(1.47e-06)]_19_\ [+3(1.15e-05)]_215_[+1(8.08e-08)]_32 5952 9.78e-05 24_[+1(3.37e-05)]_286_\ [+2(1.47e-06)]_162 5993 1.84e-05 3_[+3(1.64e-07)]_424_[+1(6.40e-06)]_\ 45 6489 4.35e-06 140_[+1(3.37e-05)]_287_\ [+2(4.82e-08)]_45 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 3 reached. ******************************************************************************** CPU: seaotter.hsd1.wa.comcast.net ********************************************************************************