******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.10.0 (Release date: Wed May 21 10:35:36 2014 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= motifs/371/371.seqs.fa ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ 21653 1.0000 500 21923 1.0000 500 22253 1.0000 500 25188 1.0000 500 25527 1.0000 500 25528 1.0000 500 25776 1.0000 500 262272 1.0000 500 263371 1.0000 500 34855 1.0000 500 38110 1.0000 500 4609 1.0000 500 4800 1.0000 500 5136 1.0000 500 6398 1.0000 500 9122 1.0000 500 9874 1.0000 500 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme motifs/371/371.seqs.fa -oc motifs/371 -dna -minw 12 -maxw 21 -nmotifs 3 -maxsize 500000 model: mod= zoops nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 12 maxw= 21 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 2 maxsites= 17 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 global: substring= yes branching= no wbranch= no em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 8500 N= 17 strands: + sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.267 C 0.241 G 0.232 T 0.260 Background letter frequencies (from dataset with add-one prior applied): A 0.267 C 0.241 G 0.232 T 0.260 ******************************************************************************** ******************************************************************************** MOTIF 1 MEME width = 15 sites = 17 llr = 175 E-value = 5.1e-003 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A 369:257269445:a pos.-specific C 74186218316119: probability G :::::2:11::23:: matrix T ::122:2::::311: bits 2.1 1.9 * 1.7 * 1.5 * ** Relative 1.3 ** * ** Entropy 1.1 **** * ** ** (14.9 bits) 0.8 **** ***** ** 0.6 ***** ***** ** 0.4 *********** ** 0.2 *************** 0.0 --------------- Multilevel CAACCAACAACAACA consensus AC C C ATG sequence G G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------- 9874 332 1.35e-09 CCAGCAAAAG CAACCAACAACAACA TGACGACGGA 34855 484 3.74e-09 ACCTCGTACA CCACCAACAACAACA CA 6398 441 3.10e-07 TATATCATTG CAACTAACAAATACA GCACTGACAC 38110 136 4.77e-07 CAAGATTTTT CAACCGACAACGCCA AAAACCCCTC 21923 400 4.77e-07 AACTGATCTC AAACCAACCAAAGCA AGGTAATCGG 5136 452 4.66e-06 CACCCGCCCG CACCCAACCAATACA GGCCACTACA 25528 327 6.22e-06 GGACGGTCTC CCACCCAAAACCACA CCCCAGACCA 4800 368 7.40e-06 CACCTCCTTT CAACCAACGCCTACA CACACAGCAC 25188 381 8.83e-06 TAATATGTAG CCATCAAAAACATCA CGACGAGAAT 21653 246 8.83e-06 GAGACCGTCT CCACCCCCAACAATA AAGTAATGAA 4609 306 1.05e-05 GATGCTGCTG AAACTACCCACAGCA ATGGCGCCGA 22253 483 1.97e-05 AATTCACTCT CAACACTCAAAGTCA ACC 263371 206 2.27e-05 TTTAAAATAA ACACCGTCAACGATA TCGTTATCGT 25527 406 3.90e-05 ACATCCTCTG AATCAAACCAAAGCA ATCATACATC 9122 109 4.71e-05 GGATGTGAGA CAACACAAACAGGCA GACTGCTGGC 25776 49 5.00e-05 GGAGGCGGTG ACATCGTCAAATCCA TACTTTTCGT 262272 237 8.74e-05 TTGTATCACG CCATTGAGCACTGCA TTGCAAGCAC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 9874 1.4e-09 331_[+1]_154 34855 3.7e-09 483_[+1]_2 6398 3.1e-07 440_[+1]_45 38110 4.8e-07 135_[+1]_350 21923 4.8e-07 399_[+1]_86 5136 4.7e-06 451_[+1]_34 25528 6.2e-06 326_[+1]_159 4800 7.4e-06 367_[+1]_118 25188 8.8e-06 380_[+1]_105 21653 8.8e-06 245_[+1]_240 4609 1e-05 305_[+1]_180 22253 2e-05 482_[+1]_3 263371 2.3e-05 205_[+1]_280 25527 3.9e-05 405_[+1]_80 9122 4.7e-05 108_[+1]_377 25776 5e-05 48_[+1]_437 262272 8.7e-05 236_[+1]_249 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=15 seqs=17 9874 ( 332) CAACCAACAACAACA 1 34855 ( 484) CCACCAACAACAACA 1 6398 ( 441) CAACTAACAAATACA 1 38110 ( 136) CAACCGACAACGCCA 1 21923 ( 400) AAACCAACCAAAGCA 1 5136 ( 452) CACCCAACCAATACA 1 25528 ( 327) CCACCCAAAACCACA 1 4800 ( 368) CAACCAACGCCTACA 1 25188 ( 381) CCATCAAAAACATCA 1 21653 ( 246) CCACCCCCAACAATA 1 4609 ( 306) AAACTACCCACAGCA 1 22253 ( 483) CAACACTCAAAGTCA 1 263371 ( 206) ACACCGTCAACGATA 1 25527 ( 406) AATCAAACCAAAGCA 1 9122 ( 109) CAACACAAACAGGCA 1 25776 ( 49) ACATCGTCAAATCCA 1 262272 ( 237) CCATTGAGCACTGCA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 15 n= 8262 bayes= 8.99152 E= 5.1e-003 14 155 -1073 -1073 114 77 -1073 -1073 172 -203 -1073 -214 -1073 177 -1073 -56 -60 143 -1073 -56 98 -3 2 -1073 140 -103 -1073 -56 -60 167 -198 -1073 127 29 -198 -1073 172 -103 -1073 -1073 62 129 -1073 -1073 62 -203 2 18 82 -103 34 -114 -1073 187 -1073 -114 190 -1073 -1073 -1073 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 15 nsites= 17 E= 5.1e-003 0.294118 0.705882 0.000000 0.000000 0.588235 0.411765 0.000000 0.000000 0.882353 0.058824 0.000000 0.058824 0.000000 0.823529 0.000000 0.176471 0.176471 0.647059 0.000000 0.176471 0.529412 0.235294 0.235294 0.000000 0.705882 0.117647 0.000000 0.176471 0.176471 0.764706 0.058824 0.000000 0.647059 0.294118 0.058824 0.000000 0.882353 0.117647 0.000000 0.000000 0.411765 0.588235 0.000000 0.000000 0.411765 0.058824 0.235294 0.294118 0.470588 0.117647 0.294118 0.117647 0.000000 0.882353 0.000000 0.117647 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- [CA][AC]ACC[ACG]AC[AC]A[CA][ATG][AG]CA -------------------------------------------------------------------------------- Time 2.73 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 MEME width = 16 sites = 12 llr = 145 E-value = 1.1e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A :::3:1::1:::3:1: pos.-specific C 2:23:3::33::2::3 probability G :a:36:482:a1:715 matrix T 8:83476248:95383 bits 2.1 * * 1.9 * * 1.7 * * 1.5 * * ** Relative 1.3 *** * *** Entropy 1.1 *** * ** *** ** (17.4 bits) 0.8 *** **** *** ** 0.6 *** **** *** *** 0.4 *** **** ******* 0.2 *** ************ 0.0 ---------------- Multilevel TGTAGTTGTTGTTGTG consensus CTCG CC AT C sequence G T T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ---------------- 4800 237 2.15e-09 TACCATCGTT TGTTGTTGCTGTTGTG TTGTTCTTTT 25776 199 1.08e-08 CAAGGGTTCA TGTCGTTGTTGTTTTG AGTTTGTTGT 21923 161 4.36e-08 AACTTATTGA TGTTGTTGGTGTAGTG GATAGTATCC 25528 34 9.09e-07 TCGTTTTGGA TGTATTGTCTGTTGTT GTTTGTCTAA 6398 145 1.09e-06 TTGGTATCGT CGTCTTTGGTGTTGTC GGATGCACCT 262272 455 1.69e-06 CGCCGACGGC TGTGTCTGCTGTCTTC ATATAGATAT 4609 93 2.50e-06 AATACATTAT CGTTGTTGTCGTCGTC ATCAGCCGTA 25188 37 2.70e-06 GGGTAGCTCC TGCCTCGGCTGTATTG GTGTTTGTGG 38110 24 2.91e-06 GTCCTCTCAT TGTATTGTATGTAGTG TTCGCGCCTC 21653 450 4.71e-06 ACAATAGCAC TGCAGCTGTCGTTTTT TAGTTTCCTA 5136 150 5.02e-06 CGAGGACGTC TGTGGAGGTTGTTGGT ATGTAGATTG 34855 282 9.97e-06 GCAGGAGCAG TGTGGTGGTCGGAGAG CCGCAGTGCA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 4800 2.2e-09 236_[+2]_248 25776 1.1e-08 198_[+2]_286 21923 4.4e-08 160_[+2]_324 25528 9.1e-07 33_[+2]_451 6398 1.1e-06 144_[+2]_340 262272 1.7e-06 454_[+2]_30 4609 2.5e-06 92_[+2]_392 25188 2.7e-06 36_[+2]_448 38110 2.9e-06 23_[+2]_461 21653 4.7e-06 449_[+2]_35 5136 5e-06 149_[+2]_335 34855 1e-05 281_[+2]_203 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=16 seqs=12 4800 ( 237) TGTTGTTGCTGTTGTG 1 25776 ( 199) TGTCGTTGTTGTTTTG 1 21923 ( 161) TGTTGTTGGTGTAGTG 1 25528 ( 34) TGTATTGTCTGTTGTT 1 6398 ( 145) CGTCTTTGGTGTTGTC 1 262272 ( 455) TGTGTCTGCTGTCTTC 1 4609 ( 93) CGTTGTTGTCGTCGTC 1 25188 ( 37) TGCCTCGGCTGTATTG 1 38110 ( 24) TGTATTGTATGTAGTG 1 21653 ( 450) TGCAGCTGTCGTTTTT 1 5136 ( 150) TGTGGAGGTTGTTGGT 1 34855 ( 282) TGTGGTGGTCGGAGAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 16 n= 8245 bayes= 10.5229 E= 1.1e-001 -1023 -53 -1023 168 -1023 -1023 211 -1023 -1023 -53 -1023 168 -10 5 11 -6 -1023 -1023 133 68 -168 5 -1023 136 -1023 -1023 84 117 -1023 -1023 184 -64 -168 47 -48 68 -1023 5 -1023 153 -1023 -1023 211 -1023 -1023 -1023 -147 182 32 -53 -1023 94 -1023 -1023 152 36 -168 -1023 -147 168 -1023 5 111 -6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 16 nsites= 12 E= 1.1e-001 0.000000 0.166667 0.000000 0.833333 0.000000 0.000000 1.000000 0.000000 0.000000 0.166667 0.000000 0.833333 0.250000 0.250000 0.250000 0.250000 0.000000 0.000000 0.583333 0.416667 0.083333 0.250000 0.000000 0.666667 0.000000 0.000000 0.416667 0.583333 0.000000 0.000000 0.833333 0.166667 0.083333 0.333333 0.166667 0.416667 0.000000 0.250000 0.000000 0.750000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.083333 0.916667 0.333333 0.166667 0.000000 0.500000 0.000000 0.000000 0.666667 0.333333 0.083333 0.000000 0.083333 0.833333 0.000000 0.250000 0.500000 0.250000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- TGT[ACGT][GT][TC][TG]G[TC][TC]GT[TA][GT]T[GCT] -------------------------------------------------------------------------------- Time 5.71 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 MEME width = 12 sites = 17 llr = 156 E-value = 1.1e+000 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A :668:62491:3 pos.-specific C :::1:2::::21 probability G a1419186:872 matrix T :3:111::1114 bits 2.1 * 1.9 * 1.7 * * * 1.5 * * * Relative 1.3 * * * ** Entropy 1.1 * * * ***** (13.3 bits) 0.8 ***** ***** 0.6 ***** ***** 0.4 *********** 0.2 ************ 0.0 ------------ Multilevel GAAAGAGGAGGT consensus TG CAA CA sequence G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ------------ 22253 41 5.50e-08 ACTCTAGAGA GAAAGAGGAGGT TTAGGTACTC 9874 99 1.59e-07 ATGATCGAGT GAAAGAGGAGGA GAGTTTTGTG 5136 45 7.31e-07 GTTTGTTGCG GTAAGAGGAGGA GGTGTAATAA 25528 151 2.12e-06 TCAGACGATT GAGAGAGGAGCA ATACTGATGC 4609 434 3.60e-06 CTTGTAGCGG GAAAGAAAAGGT TGGTTGTGAG 25527 104 9.82e-06 AGATGGGGTA GTACGAGGAGGG TGTGTGTGTC 262272 351 1.26e-05 TGACATCGAT GTGAGTGAAGGT TGAAGGGATA 38110 412 1.74e-05 CCGTGATTAC GAGAGAGAAAGA GAGAGCGGCG 6398 328 3.52e-05 CGCAAGTGAA GAAAGTGAAGGC CTCTCTCTGT 9122 197 4.10e-05 ATCTGAGCGC GAACGGGGAGGG CAGTCTTGAA 21653 405 4.10e-05 GAGAGAGAGA GAGAGCGGAACT ACTGTGCTGA 263371 135 6.96e-05 CGACGAACCA GAAAGCAGATGT CAGCGCCGCA 25188 59 6.96e-05 ATTGGTGTTT GTGGGAGGAGCG TCGAAGTGCC 21923 211 6.96e-05 ATGTTGTTCG GAGAGCAGAGTT GTTGGTTGGT 34855 198 8.55e-05 CAACCGCGAC GAAATAGAAGCG ATCGCCGACT 25776 96 9.17e-05 CCGCTGTGGT GGGTGAGGAGGA TCGATCGATG 4800 415 1.94e-04 TTGCGGGATC GTAAGCAATGGT GGTGTTTGTG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 22253 5.5e-08 40_[+3]_448 9874 1.6e-07 98_[+3]_390 5136 7.3e-07 44_[+3]_444 25528 2.1e-06 150_[+3]_338 4609 3.6e-06 433_[+3]_55 25527 9.8e-06 103_[+3]_385 262272 1.3e-05 350_[+3]_138 38110 1.7e-05 411_[+3]_77 6398 3.5e-05 327_[+3]_161 9122 4.1e-05 196_[+3]_292 21653 4.1e-05 404_[+3]_84 263371 7e-05 134_[+3]_354 25188 7e-05 58_[+3]_430 21923 7e-05 210_[+3]_278 34855 8.6e-05 197_[+3]_291 25776 9.2e-05 95_[+3]_393 4800 0.00019 414_[+3]_74 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=12 seqs=17 22253 ( 41) GAAAGAGGAGGT 1 9874 ( 99) GAAAGAGGAGGA 1 5136 ( 45) GTAAGAGGAGGA 1 25528 ( 151) GAGAGAGGAGCA 1 4609 ( 434) GAAAGAAAAGGT 1 25527 ( 104) GTACGAGGAGGG 1 262272 ( 351) GTGAGTGAAGGT 1 38110 ( 412) GAGAGAGAAAGA 1 6398 ( 328) GAAAGTGAAGGC 1 9122 ( 197) GAACGGGGAGGG 1 21653 ( 405) GAGAGCGGAACT 1 263371 ( 135) GAAAGCAGATGT 1 25188 ( 59) GTGGGAGGAGCG 1 21923 ( 211) GAGAGCAGAGTT 1 34855 ( 198) GAAATAGAAGCG 1 25776 ( 96) GGGTGAGGAGGA 1 4800 ( 415) GTAAGCAATGGT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 8313 bayes= 9.00042 E= 1.1e+000 -1073 -1073 211 -1073 127 -1073 -198 18 114 -1073 83 -1073 152 -103 -198 -214 -1073 -1073 202 -214 114 -3 -198 -114 -18 -1073 172 -1073 40 -1073 148 -1073 181 -1073 -1073 -214 -118 -1073 183 -214 -1073 -3 161 -214 14 -203 2 66 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 17 E= 1.1e+000 0.000000 0.000000 1.000000 0.000000 0.647059 0.000000 0.058824 0.294118 0.588235 0.000000 0.411765 0.000000 0.764706 0.117647 0.058824 0.058824 0.000000 0.000000 0.941176 0.058824 0.588235 0.235294 0.058824 0.117647 0.235294 0.000000 0.764706 0.000000 0.352941 0.000000 0.647059 0.000000 0.941176 0.000000 0.000000 0.058824 0.117647 0.000000 0.823529 0.058824 0.000000 0.235294 0.705882 0.058824 0.294118 0.058824 0.235294 0.411765 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- G[AT][AG]AG[AC][GA][GA]AG[GC][TAG] -------------------------------------------------------------------------------- Time 8.73 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 21653 2.63e-05 245_[+1(8.83e-06)]_144_\ [+3(4.10e-05)]_33_[+2(4.71e-06)]_35 21923 4.55e-08 160_[+2(4.36e-08)]_34_\ [+3(6.96e-05)]_177_[+1(4.77e-07)]_86 22253 2.41e-05 40_[+3(5.50e-08)]_430_\ [+1(1.97e-05)]_3 25188 2.55e-05 36_[+2(2.70e-06)]_6_[+3(6.96e-05)]_\ 202_[+1(9.19e-05)]_93_[+1(8.83e-06)]_105 25527 2.66e-03 103_[+3(9.82e-06)]_290_\ [+1(3.90e-05)]_80 25528 3.17e-07 33_[+2(9.09e-07)]_101_\ [+3(2.12e-06)]_164_[+1(6.22e-06)]_159 25776 1.10e-06 48_[+1(5.00e-05)]_32_[+3(9.17e-05)]_\ 27_[+2(8.26e-05)]_48_[+2(1.08e-08)]_286 262272 2.82e-05 236_[+1(8.74e-05)]_99_\ [+3(1.26e-05)]_92_[+2(1.69e-06)]_30 263371 7.40e-03 134_[+3(6.96e-05)]_59_\ [+1(2.27e-05)]_280 34855 9.32e-08 197_[+3(8.55e-05)]_72_\ [+2(9.97e-06)]_158_[+1(2.27e-05)]_13_[+1(3.74e-09)]_2 38110 5.96e-07 23_[+2(2.91e-06)]_27_[+1(3.66e-05)]_\ 54_[+1(4.77e-07)]_261_[+3(1.74e-05)]_77 4609 2.03e-06 92_[+2(2.50e-06)]_197_\ [+1(1.05e-05)]_113_[+3(3.60e-06)]_55 4800 8.81e-08 236_[+2(2.15e-09)]_19_\ [+2(3.70e-05)]_80_[+1(7.40e-06)]_118 5136 4.37e-07 44_[+3(7.31e-07)]_93_[+2(5.02e-06)]_\ 286_[+1(4.66e-06)]_34 6398 3.12e-07 144_[+2(1.09e-06)]_167_\ [+3(3.52e-05)]_101_[+1(3.10e-07)]_45 9122 1.06e-02 108_[+1(4.71e-05)]_73_\ [+3(4.10e-05)]_292 9874 8.18e-09 98_[+3(1.59e-07)]_221_\ [+1(1.35e-09)]_154 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 3 reached. ******************************************************************************** CPU: seaotter.hsd1.wa.comcast.net ********************************************************************************