******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.10.0 (Release date: Wed May 21 10:35:36 2014 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= motifs/479/479.seqs.fa ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ 22888 1.0000 500 23834 1.0000 500 24133 1.0000 500 264915 1.0000 500 2777 1.0000 500 2838 1.0000 500 3617 1.0000 500 3901 1.0000 500 5353 1.0000 500 6143 1.0000 500 6629 1.0000 500 6825 1.0000 500 7061 1.0000 500 7365 1.0000 500 7628 1.0000 500 8542 1.0000 500 9374 1.0000 500 9500 1.0000 500 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme motifs/479/479.seqs.fa -oc motifs/479 -dna -minw 12 -maxw 21 -nmotifs 3 -maxsize 500000 model: mod= zoops nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 12 maxw= 21 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 2 maxsites= 18 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 global: substring= yes branching= no wbranch= no em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 9000 N= 18 strands: + sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.281 C 0.225 G 0.230 T 0.264 Background letter frequencies (from dataset with add-one prior applied): A 0.281 C 0.225 G 0.230 T 0.264 ******************************************************************************** ******************************************************************************** MOTIF 1 MEME width = 16 sites = 17 llr = 177 E-value = 1.1e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A :8:12815:::22313 pos.-specific C :1::2:::2:13145: probability G 91993295286363:6 matrix T 111:3:::62221:41 bits 2.1 1.9 1.7 * * 1.5 * ** * Relative 1.3 * ** ** * Entropy 1.1 * ** *** * (15.1 bits) 0.9 * ** *** ** * 0.6 **** ****** * ** 0.4 **** ****** **** 0.2 **** ****** **** 0.0 ---------------- Multilevel GAGGGAGATGGCGCCG consensus T GCTTG ATA sequence A T G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ---------------- 9500 10 6.70e-10 TTCGAAGGG GAGGTAGGTGGCGCCG AGGAGAGGGT 6825 117 2.67e-07 GGACGCGGGA GAGGGAGGTGTTGATG GCGAGGAGGA 2777 314 4.52e-07 CGTGGCGTGT GAGGAAGACGTGGCTG TTGTTCATGG 264915 265 4.52e-07 TACCACTACT GAGGTAGATGGGGCAA TTTGCTACAT 7061 408 3.03e-06 ATGCGATAAC GATGCAGGTGTAGCCG ATAGTTGTAA 3901 87 3.35e-06 TGTCCAGTTG GATGCAGATGGAGATG AAAAGATTAA 9374 146 3.68e-06 ACTGGCGTTG GAGGTAGGTGCTACCA TTACGTTGGG 8542 249 4.88e-06 GTCGTTGTTG TAGGGAGGTGGCCGCG TAGAGCTACG 6143 309 5.86e-06 TTGTCTTCTC GTGGTAGACGTCGACG ATCATGTCAA 6629 120 9.02e-06 ACCTTCATCG GCGGGAGGGGGCTGCG AACGGAATGA 7628 35 9.79e-06 GTCGGTGGTG GGGGGAGGCTGGGGCA CGGTCATGTT 24133 104 9.79e-06 GGAGCACGTG GAGGCAAGGTGGGACG CAAGTTTAGT 3617 355 1.25e-05 ACCTGAACTT GAGAGAGATGGTACCA AGCCTGCCTG 5353 335 1.35e-05 CAGGAGGGGG GAGGAGGATTGAGGAG TGTGTTGGTG 23834 340 1.83e-05 TGGTGGTGTT GAGGAAGACTGGCATA CCGTTGTGTG 22888 198 2.82e-05 GACGAGTGGA GAGGAGGATGGCAGTT TGTCTTCATT 2838 170 1.23e-04 AGAAATGTAT GCGGTGAAGGCTGCTG GGCTTTGCTG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 9500 6.7e-10 9_[+1]_475 6825 2.7e-07 116_[+1]_368 2777 4.5e-07 313_[+1]_171 264915 4.5e-07 264_[+1]_220 7061 3e-06 407_[+1]_77 3901 3.3e-06 86_[+1]_398 9374 3.7e-06 145_[+1]_339 8542 4.9e-06 248_[+1]_236 6143 5.9e-06 308_[+1]_176 6629 9e-06 119_[+1]_365 7628 9.8e-06 34_[+1]_450 24133 9.8e-06 103_[+1]_381 3617 1.2e-05 354_[+1]_130 5353 1.4e-05 334_[+1]_150 23834 1.8e-05 339_[+1]_145 22888 2.8e-05 197_[+1]_287 2838 0.00012 169_[+1]_315 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=16 seqs=17 9500 ( 10) GAGGTAGGTGGCGCCG 1 6825 ( 117) GAGGGAGGTGTTGATG 1 2777 ( 314) GAGGAAGACGTGGCTG 1 264915 ( 265) GAGGTAGATGGGGCAA 1 7061 ( 408) GATGCAGGTGTAGCCG 1 3901 ( 87) GATGCAGATGGAGATG 1 9374 ( 146) GAGGTAGGTGCTACCA 1 8542 ( 249) TAGGGAGGTGGCCGCG 1 6143 ( 309) GTGGTAGACGTCGACG 1 6629 ( 120) GCGGGAGGGGGCTGCG 1 7628 ( 35) GGGGGAGGCTGGGGCA 1 24133 ( 104) GAGGCAAGGTGGGACG 1 3617 ( 355) GAGAGAGATGGTACCA 1 5353 ( 335) GAGGAGGATTGAGGAG 1 23834 ( 340) GAGGAAGACTGGCATA 1 22888 ( 198) GAGGAGGATGGCAGTT 1 2838 ( 170) GCGGTGAAGGCTGCTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 16 n= 8730 bayes= 9.07116 E= 1.1e-001 -1073 -1073 203 -216 144 -94 -196 -216 -1073 -1073 194 -116 -225 -1073 203 -1073 -26 -35 35 16 155 -1073 -38 -1073 -126 -1073 194 -1073 91 -1073 103 -1073 -1073 6 -38 116 -1073 -1073 173 -16 -1073 -94 149 -16 -67 38 35 -16 -67 -94 149 -216 7 87 35 -1073 -126 123 -1073 42 7 -1073 149 -216 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 16 nsites= 17 E= 1.1e-001 0.000000 0.000000 0.941176 0.058824 0.764706 0.117647 0.058824 0.058824 0.000000 0.000000 0.882353 0.117647 0.058824 0.000000 0.941176 0.000000 0.235294 0.176471 0.294118 0.294118 0.823529 0.000000 0.176471 0.000000 0.117647 0.000000 0.882353 0.000000 0.529412 0.000000 0.470588 0.000000 0.000000 0.235294 0.176471 0.588235 0.000000 0.000000 0.764706 0.235294 0.000000 0.117647 0.647059 0.235294 0.176471 0.294118 0.294118 0.235294 0.176471 0.117647 0.647059 0.058824 0.294118 0.411765 0.294118 0.000000 0.117647 0.529412 0.000000 0.352941 0.294118 0.000000 0.647059 0.058824 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- GAGG[GTA]AG[AG][TC][GT][GT][CGT]G[CAG][CT][GA] -------------------------------------------------------------------------------- Time 2.75 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 MEME width = 21 sites = 12 llr = 165 E-value = 2.0e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A ::312:63:22:331133:8: pos.-specific C 8518293:9:3a:758:47:8 probability G :2::3:2::32::::12::1: matrix T 236241:8154:8:4153322 bits 2.1 * 1.9 * 1.7 * * * 1.5 * * * * * Relative 1.3 * * * * * Entropy 1.1 * * * ** *** * * (19.9 bits) 0.9 * * * ** *** * *** 0.6 **** **** ***** *** 0.4 **** ***** ********** 0.2 **** **************** 0.0 --------------------- Multilevel CCTCTCATCTTCTCCCTCCAC consensus TA G CA GC AAT AAT sequence T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 7061 269 2.10e-10 CTCCCTTGAT CTTCTCGTCGTCTCTCTCCAC AGACACCCTC 9374 470 5.52e-09 CTCTATCTCT CCTCTCCTCTGCTCCGTACAC CCCTTGCAAC 7628 363 3.59e-08 TTCTCTCTCT TCTCTCCTCTCCTCTCTCTTC TCTCCTTTCT 6825 476 6.64e-08 AAGCCCAACA CCACCCAACAACTCTCGCCAC AGTC 2777 77 8.07e-08 CCGGTTCAAT CTTCACATCTACTCCAATCAC TTCAGCCACA 6629 425 1.18e-07 CTCTACAAGT CCACTCAACTTCAATCTACAT CAAGCACTCT 3901 414 1.84e-07 TTCCTGCTAC CTTCGTGTCTGCTACCTTCAC TCTCGAAGCA 7365 254 4.89e-07 AGACGCCCTG CTACGCAACGTCAACCAACGC CGTACCAACG 22888 324 7.62e-07 GCCAAGTTGT CCTTTCATTTTCTCCTAATAC CCGAGTTGTC 3617 86 8.78e-07 TTGCAAGGTC TGACCCATCATCAACCATCAC GTCATGATTT 24133 451 9.41e-07 TTCACACCTC CCCTGCCTCGCCTCTCGCTTC AACAGATATG 8542 389 2.31e-06 ATAGTATACT CGTAACATCGCCTCACTCTAT TGTCGTTAAT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 7061 2.1e-10 268_[+2]_211 9374 5.5e-09 469_[+2]_10 7628 3.6e-08 362_[+2]_117 6825 6.6e-08 475_[+2]_4 2777 8.1e-08 76_[+2]_403 6629 1.2e-07 424_[+2]_55 3901 1.8e-07 413_[+2]_66 7365 4.9e-07 253_[+2]_226 22888 7.6e-07 323_[+2]_156 3617 8.8e-07 85_[+2]_394 24133 9.4e-07 450_[+2]_29 8542 2.3e-06 388_[+2]_91 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=21 seqs=12 7061 ( 269) CTTCTCGTCGTCTCTCTCCAC 1 9374 ( 470) CCTCTCCTCTGCTCCGTACAC 1 7628 ( 363) TCTCTCCTCTCCTCTCTCTTC 1 6825 ( 476) CCACCCAACAACTCTCGCCAC 1 2777 ( 77) CTTCACATCTACTCCAATCAC 1 6629 ( 425) CCACTCAACTTCAATCTACAT 1 3901 ( 414) CTTCGTGTCTGCTACCTTCAC 1 7365 ( 254) CTACGCAACGTCAACCAACGC 1 22888 ( 324) CCTTTCATTTTCTCCTAATAC 1 3617 ( 86) TGACCCATCATCAACCATCAC 1 24133 ( 451) CCCTGCCTCGCCTCTCGCTTC 1 8542 ( 389) CGTAACATCGCCTCACTCTAT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 8640 bayes= 10.5905 E= 2.0e-001 -1023 189 -1023 -66 -1023 115 -46 34 25 -143 -1023 115 -175 173 -1023 -66 -75 -43 12 66 -1023 202 -1023 -166 105 15 -46 -1023 -17 -1023 -1023 151 -1023 202 -1023 -166 -75 -1023 53 92 -75 15 -46 66 -1023 215 -1023 -1023 -17 -1023 -1023 151 25 156 -1023 -1023 -175 115 -1023 66 -175 173 -146 -166 25 -1023 -46 92 25 89 -1023 -8 -1023 156 -1023 34 142 -1023 -146 -66 -1023 189 -1023 -66 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 12 E= 2.0e-001 0.000000 0.833333 0.000000 0.166667 0.000000 0.500000 0.166667 0.333333 0.333333 0.083333 0.000000 0.583333 0.083333 0.750000 0.000000 0.166667 0.166667 0.166667 0.250000 0.416667 0.000000 0.916667 0.000000 0.083333 0.583333 0.250000 0.166667 0.000000 0.250000 0.000000 0.000000 0.750000 0.000000 0.916667 0.000000 0.083333 0.166667 0.000000 0.333333 0.500000 0.166667 0.250000 0.166667 0.416667 0.000000 1.000000 0.000000 0.000000 0.250000 0.000000 0.000000 0.750000 0.333333 0.666667 0.000000 0.000000 0.083333 0.500000 0.000000 0.416667 0.083333 0.750000 0.083333 0.083333 0.333333 0.000000 0.166667 0.500000 0.333333 0.416667 0.000000 0.250000 0.000000 0.666667 0.000000 0.333333 0.750000 0.000000 0.083333 0.166667 0.000000 0.833333 0.000000 0.166667 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- C[CT][TA]C[TG]C[AC][TA]C[TG][TC]C[TA][CA][CT]C[TA][CAT][CT]AC -------------------------------------------------------------------------------- Time 5.33 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 MEME width = 12 sites = 14 llr = 143 E-value = 1.5e+000 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A 94:6:39129:4 pos.-specific C 149:a6196:95 probability G :::::::::11: matrix T :214:1::2::1 bits 2.1 * 1.9 * 1.7 * * 1.5 * * * * ** Relative 1.3 * * * ** ** Entropy 1.1 * * * ** ** (14.7 bits) 0.9 * ****** ** 0.6 * ********** 0.4 ************ 0.2 ************ 0.0 ------------ Multilevel AACACCACCACC consensus C T A A A sequence T T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ------------ 5353 24 9.21e-08 ACGATAATCC ACCACCACCACC AGATGTAGTA 6825 416 6.25e-07 TCAACCAAAA ACCACAACCACC GTCCACCGTC 7365 311 1.55e-06 TGCCCTCTTC ACCACCACAACA CGGTAGCTAT 2777 12 2.27e-06 CTGTCGTTGC AACTCAACCACA TCCAGAAATC 23834 455 2.97e-06 ACTCTCACAC ACCTCCCCCACC CGTCAAAATA 3617 484 7.06e-06 CTCTTCTTGC ATTACCACCACA GAACC 24133 483 7.06e-06 ACAGATATGT ACCTCCACCGCC CATACC 8542 124 1.15e-05 AACCGCCGCA AACACAAACACA GTTGACCAAG 6629 101 1.28e-05 AGAGTTGAAT CTCTCCACCACC TTCATCGGCG 22888 456 1.61e-05 CACTATCAAT AACACCACAAGC CCCGCCTTGC 6143 333 2.03e-05 CGATCATGTC AACTCTACTACC TTGAACCTCT 2838 381 2.21e-05 CTGAGTGATC ATCACCAATACA GCTGAGAGTT 7061 181 2.33e-05 TCCATTACCA AACACACCAACA ACTCACCGTA 264915 253 4.70e-05 TGACAGAATC AATACCACTACT GAGGTAGATG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 5353 9.2e-08 23_[+3]_465 6825 6.2e-07 415_[+3]_73 7365 1.6e-06 310_[+3]_178 2777 2.3e-06 11_[+3]_477 23834 3e-06 454_[+3]_34 3617 7.1e-06 483_[+3]_5 24133 7.1e-06 482_[+3]_6 8542 1.2e-05 123_[+3]_365 6629 1.3e-05 100_[+3]_388 22888 1.6e-05 455_[+3]_33 6143 2e-05 332_[+3]_156 2838 2.2e-05 380_[+3]_108 7061 2.3e-05 180_[+3]_308 264915 4.7e-05 252_[+3]_236 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=12 seqs=14 5353 ( 24) ACCACCACCACC 1 6825 ( 416) ACCACAACCACC 1 7365 ( 311) ACCACCACAACA 1 2777 ( 12) AACTCAACCACA 1 23834 ( 455) ACCTCCCCCACC 1 3617 ( 484) ATTACCACCACA 1 24133 ( 483) ACCTCCACCGCC 1 8542 ( 124) AACACAAACACA 1 6629 ( 101) CTCTCCACCACC 1 22888 ( 456) AACACCACAAGC 1 6143 ( 333) AACTCTACTACC 1 2838 ( 381) ATCACCAATACA 1 7061 ( 181) AACACACCAACA 1 264915 ( 253) AATACCACTACT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 8802 bayes= 10.5177 E= 1.5e+000 172 -166 -1045 -1045 61 66 -1045 -30 -1045 193 -1045 -88 119 -1045 -1045 44 -1045 215 -1045 -1045 2 151 -1045 -188 161 -66 -1045 -1045 -98 193 -1045 -1045 -39 134 -1045 -30 172 -1045 -168 -1045 -1045 204 -168 -1045 61 115 -1045 -188 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 14 E= 1.5e+000 0.928571 0.071429 0.000000 0.000000 0.428571 0.357143 0.000000 0.214286 0.000000 0.857143 0.000000 0.142857 0.642857 0.000000 0.000000 0.357143 0.000000 1.000000 0.000000 0.000000 0.285714 0.642857 0.000000 0.071429 0.857143 0.142857 0.000000 0.000000 0.142857 0.857143 0.000000 0.000000 0.214286 0.571429 0.000000 0.214286 0.928571 0.000000 0.071429 0.000000 0.000000 0.928571 0.071429 0.000000 0.428571 0.500000 0.000000 0.071429 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- A[ACT]C[AT]C[CA]AC[CAT]AC[CA] -------------------------------------------------------------------------------- Time 7.84 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 22888 6.36e-06 197_[+1(2.82e-05)]_110_\ [+2(7.62e-07)]_111_[+3(1.61e-05)]_33 23834 2.52e-04 339_[+1(1.83e-05)]_99_\ [+3(2.97e-06)]_34 24133 1.44e-06 103_[+1(9.79e-06)]_331_\ [+2(9.41e-07)]_11_[+3(7.06e-06)]_6 264915 3.55e-04 252_[+3(4.70e-05)]_[+1(4.52e-07)]_\ 220 2777 3.29e-09 11_[+3(2.27e-06)]_53_[+2(8.07e-08)]_\ 216_[+1(4.52e-07)]_171 2838 1.84e-02 380_[+3(2.21e-05)]_108 3617 1.68e-06 85_[+2(8.78e-07)]_248_\ [+1(1.25e-05)]_113_[+3(7.06e-06)]_5 3901 1.94e-05 86_[+1(3.35e-06)]_311_\ [+2(1.84e-07)]_66 5353 1.94e-05 23_[+3(9.21e-08)]_299_\ [+1(1.35e-05)]_150 6143 8.80e-04 308_[+1(5.86e-06)]_8_[+3(2.03e-05)]_\ 156 6629 3.48e-07 100_[+3(1.28e-05)]_7_[+1(9.02e-06)]_\ 289_[+2(1.18e-07)]_55 6825 5.09e-10 116_[+1(2.67e-07)]_283_\ [+3(6.25e-07)]_48_[+2(6.64e-08)]_4 7061 6.65e-10 180_[+3(2.33e-05)]_76_\ [+2(2.10e-10)]_118_[+1(3.03e-06)]_77 7365 2.38e-05 253_[+2(4.89e-07)]_36_\ [+3(1.55e-06)]_178 7628 5.79e-06 34_[+1(9.79e-06)]_312_\ [+2(3.59e-08)]_5_[+2(7.32e-08)]_91 8542 2.68e-06 123_[+3(1.15e-05)]_113_\ [+1(4.88e-06)]_124_[+2(2.31e-06)]_91 9374 8.68e-07 145_[+1(3.68e-06)]_308_\ [+2(5.52e-09)]_10 9500 2.04e-05 9_[+1(6.70e-10)]_475 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 3 reached. ******************************************************************************** CPU: seaotter.hsd1.wa.comcast.net ********************************************************************************