******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.10.0 (Release date: Wed May 21 10:35:36 2014 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= motifs/67/67.seqs.fa ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ 1077 1.0000 500 21931 1.0000 500 22907 1.0000 500 262254 1.0000 500 268458 1.0000 500 269448 1.0000 500 270246 1.0000 500 32216 1.0000 500 33454 1.0000 500 5289 1.0000 500 5511 1.0000 500 8636 1.0000 500 9271 1.0000 500 9605 1.0000 500 9830 1.0000 500 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme motifs/67/67.seqs.fa -oc motifs/67 -dna -minw 12 -maxw 21 -nmotifs 3 -maxsize 500000 model: mod= zoops nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 12 maxw= 21 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 2 maxsites= 15 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 global: substring= yes branching= no wbranch= no em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 7500 N= 15 strands: + sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.266 C 0.220 G 0.255 T 0.260 Background letter frequencies (from dataset with add-one prior applied): A 0.266 C 0.220 G 0.255 T 0.260 ******************************************************************************** ******************************************************************************** MOTIF 1 MEME width = 21 sites = 9 llr = 144 E-value = 3.6e-003 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A 111:::1::1::13:11::12 pos.-specific C 792a2a:a633a7237:7438 probability G 2:::1:1:1::::2:13261: matrix T ::7:7:8:367:227161:4: bits 2.2 * * * * 2.0 * * * * 1.7 * * * * * 1.5 * * * * * Relative 1.3 * * * * * * Entropy 1.1 * * * * ** * * * (23.1 bits) 0.9 ******** *** * ** * 0.7 ************* ***** * 0.4 ************* ***** * 0.2 ************* ******* 0.0 --------------------- Multilevel CCTCTCTCCTTCCATCTCGTC consensus G C C TCC TCC GGCCA sequence G T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 9830 202 2.55e-10 GGAGTGGAGC CCTCTCTCCTCCTGCCTCCCC GTGGAACCTC 5511 393 3.85e-10 GGGTGGTAGA GCTCTCTCGTTCCATCTCCTC TGTTTCACTC 21931 480 1.07e-09 TGGGCTTCGG CCCCCCTCCTTCCATTTCGTC 9605 115 8.43e-09 AACACCAAAA CATCTCTCTCTCTCTCGCGTC GATTCTTTAT 270246 437 2.11e-08 AGATCCTATC ACTCTCTCCTCCCTTCGCGGA AACCGATTTG 32216 41 5.53e-08 AAGAATGCCA CCTCGCTCTTTCCATATGGCA AACCTCGTCC 5289 462 7.42e-08 TTCTCCCTCG CCACTCGCCACCCGCCGCCCC TGCCACGGCC 1077 440 1.55e-07 ACACAAAAAG CCCCCCACTCTCCCTCTTGAC TCCCTCTGTT 269448 280 3.13e-07 AAGCACCTTT GCTCTCTCCCTCATCGAGCTC AGGTTGGCAC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 9830 2.6e-10 201_[+1]_278 5511 3.9e-10 392_[+1]_87 21931 1.1e-09 479_[+1] 9605 8.4e-09 114_[+1]_365 270246 2.1e-08 436_[+1]_43 32216 5.5e-08 40_[+1]_439 5289 7.4e-08 461_[+1]_18 1077 1.6e-07 439_[+1]_40 269448 3.1e-07 279_[+1]_200 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=21 seqs=9 9830 ( 202) CCTCTCTCCTCCTGCCTCCCC 1 5511 ( 393) GCTCTCTCGTTCCATCTCCTC 1 21931 ( 480) CCCCCCTCCTTCCATTTCGTC 1 9605 ( 115) CATCTCTCTCTCTCTCGCGTC 1 270246 ( 437) ACTCTCTCCTCCCTTCGCGGA 1 32216 ( 41) CCTCGCTCTTTCCATATGGCA 1 5289 ( 462) CCACTCGCCACCCGCCGCCCC 1 1077 ( 440) CCCCCCACTCTCCCTCTTGAC 1 269448 ( 280) GCTCTCTCCCTCATCGAGCTC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 7200 bayes= 9.77651 E= 3.6e-003 -126 160 -20 -982 -126 201 -982 -982 -126 2 -982 136 -982 218 -982 -982 -982 2 -119 136 -982 218 -982 -982 -126 -982 -119 158 -982 218 -982 -982 -982 134 -119 36 -126 60 -982 110 -982 60 -982 136 -982 218 -982 -982 -126 160 -982 -22 33 2 -20 -22 -982 60 -982 136 -126 160 -119 -122 -126 -982 39 110 -982 160 -20 -122 -982 101 112 -982 -126 60 -119 77 -26 182 -982 -982 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 9 E= 3.6e-003 0.111111 0.666667 0.222222 0.000000 0.111111 0.888889 0.000000 0.000000 0.111111 0.222222 0.000000 0.666667 0.000000 1.000000 0.000000 0.000000 0.000000 0.222222 0.111111 0.666667 0.000000 1.000000 0.000000 0.000000 0.111111 0.000000 0.111111 0.777778 0.000000 1.000000 0.000000 0.000000 0.000000 0.555556 0.111111 0.333333 0.111111 0.333333 0.000000 0.555556 0.000000 0.333333 0.000000 0.666667 0.000000 1.000000 0.000000 0.000000 0.111111 0.666667 0.000000 0.222222 0.333333 0.222222 0.222222 0.222222 0.000000 0.333333 0.000000 0.666667 0.111111 0.666667 0.111111 0.111111 0.111111 0.000000 0.333333 0.555556 0.000000 0.666667 0.222222 0.111111 0.000000 0.444444 0.555556 0.000000 0.111111 0.333333 0.111111 0.444444 0.222222 0.777778 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- [CG]C[TC]C[TC]CTC[CT][TC][TC]C[CT][ACGT][TC]C[TG][CG][GC][TC][CA] -------------------------------------------------------------------------------- Time 1.78 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 MEME width = 15 sites = 15 llr = 153 E-value = 8.6e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A :95:12:56:1974: pos.-specific C ::4::4::113:331 probability G 711991a51751:17 matrix T 3::1:3::331::22 bits 2.2 2.0 * 1.7 * 1.5 * * * Relative 1.3 * ** * * Entropy 1.1 ** ** * ** (14.7 bits) 0.9 ** ** ** * ** * 0.7 ***** ** * ** * 0.4 ***** ******* * 0.2 *************** 0.0 --------------- Multilevel GAAGGCGAAGGAAAG consensus T C T GTTC CCT sequence A T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------- 32216 264 7.07e-08 ATGCGTACAT GAAGGAGAAGGAACG TACCAAGAAG 262254 301 5.89e-07 GGTCGAGAGT GACGGTGGTGGAATG TGACAATGCG 9830 179 2.29e-06 TATGTTTTGT GAGGGCGGAGGAAGG AGTGGAGCCC 33454 326 2.84e-06 AACACACTGT TAAGGAGGATCAAAG TGCAGACTCA 270246 205 2.84e-06 AACACACTGT TAAGGAGGATCAAAG TGCAGACTCA 9271 431 3.90e-06 TGTGGCGTGG GAAGGCGATGTAATG CGTTTGATAT 9605 333 5.79e-06 TGTCCATGAC GACGGCGACGGGAAG CGGCAAACAA 5289 288 5.79e-06 TTTCTGAACC GACTGTGAAGCAACG GAGTGAGGTG 1077 331 6.33e-06 GGTTGAGAGC GAAGGGGAAGGACTT AGGAATTTTG 8636 159 1.08e-05 CGAAGACACG GACGGCGAAGAACAC CCAAAAAAGA 269448 430 1.08e-05 GGTGCAGAAA TAAGGTGGTTGAAAT TCAGTGTTGT 5511 447 1.18e-05 TCCGTCAGAA GACGGTGGTTGACCT CTCCCTCGCA 21931 351 2.93e-05 CTTGACCTCT GAAGGCGAGGAGACG GCTACCCTCT 268458 157 4.61e-05 CAATTTGAGT GGAGAGGAAGCAAAG TCGCTATCTG 22907 451 7.35e-05 GATCACCGAC TACGACGGACGACGG CCAACAACAC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 32216 7.1e-08 263_[+2]_222 262254 5.9e-07 300_[+2]_185 9830 2.3e-06 178_[+2]_307 33454 2.8e-06 325_[+2]_160 270246 2.8e-06 204_[+2]_281 9271 3.9e-06 430_[+2]_55 9605 5.8e-06 332_[+2]_153 5289 5.8e-06 287_[+2]_198 1077 6.3e-06 330_[+2]_155 8636 1.1e-05 158_[+2]_327 269448 1.1e-05 429_[+2]_56 5511 1.2e-05 446_[+2]_39 21931 2.9e-05 350_[+2]_135 268458 4.6e-05 156_[+2]_329 22907 7.3e-05 450_[+2]_35 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=15 seqs=15 32216 ( 264) GAAGGAGAAGGAACG 1 262254 ( 301) GACGGTGGTGGAATG 1 9830 ( 179) GAGGGCGGAGGAAGG 1 33454 ( 326) TAAGGAGGATCAAAG 1 270246 ( 205) TAAGGAGGATCAAAG 1 9271 ( 431) GAAGGCGATGTAATG 1 9605 ( 333) GACGGCGACGGGAAG 1 5289 ( 288) GACTGTGAAGCAACG 1 1077 ( 331) GAAGGGGAAGGACTT 1 8636 ( 159) GACGGCGAAGAACAC 1 269448 ( 430) TAAGGTGGTTGAAAT 1 5511 ( 447) GACGGTGGTTGACCT 1 21931 ( 351) GAAGGCGAGGAGACG 1 268458 ( 157) GGAGAGGAAGCAAAG 1 22907 ( 451) TACGACGGACGACGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 15 n= 7290 bayes= 8.92184 E= 8.6e-001 -1055 -1055 153 4 181 -1055 -193 -1055 100 86 -193 -1055 -1055 -1055 187 -196 -99 -1055 177 -1055 -41 86 -93 4 -1055 -1055 197 -1055 100 -1055 87 -1055 117 -172 -193 4 -1055 -172 139 4 -99 28 107 -196 170 -1055 -93 -1055 146 28 -1055 -1055 59 28 -93 -38 -1055 -172 153 -38 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 15 nsites= 15 E= 8.6e-001 0.000000 0.000000 0.733333 0.266667 0.933333 0.000000 0.066667 0.000000 0.533333 0.400000 0.066667 0.000000 0.000000 0.000000 0.933333 0.066667 0.133333 0.000000 0.866667 0.000000 0.200000 0.400000 0.133333 0.266667 0.000000 0.000000 1.000000 0.000000 0.533333 0.000000 0.466667 0.000000 0.600000 0.066667 0.066667 0.266667 0.000000 0.066667 0.666667 0.266667 0.133333 0.266667 0.533333 0.066667 0.866667 0.000000 0.133333 0.000000 0.733333 0.266667 0.000000 0.000000 0.400000 0.266667 0.133333 0.200000 0.000000 0.066667 0.733333 0.200000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- [GT]A[AC]GG[CTA]G[AG][AT][GT][GC]A[AC][ACT][GT] -------------------------------------------------------------------------------- Time 3.54 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 MEME width = 21 sites = 14 llr = 176 E-value = 1.1e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A 216:1:1:2:261:5:72:1: pos.-specific C 11:1211:::1::1:::1::3 probability G 72261672297::938:436: matrix T :623621861:4912233727 bits 2.2 2.0 1.7 1.5 * * Relative 1.3 * ** * Entropy 1.1 * * ** ** * * (18.2 bits) 0.9 * * * ***** ** * * 0.7 * * *** ***** ** *** 0.4 ***************** *** 0.2 ***************** *** 0.0 --------------------- Multilevel GTAGTGGTTGGATGAGAGTGT consensus AGGTCT GA AT GTTTGTC sequence T G T A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 5511 119 1.61e-09 AGCAAGCTAT GTGGTCGTTGGTTGAGAATGT TAGCAAGGGG 1077 221 1.06e-08 GTGGACAAGC ATAGTGGTGGGATGATACTGT TGTGGTTATG 33454 360 2.92e-08 AAAAGAAAGT GTATCGGTTGAATGAGTGTTT ATATTTCAGA 270246 239 2.92e-08 AAAAGAAAGT GTATCGGTTGAATGAGTGTTT ATATTTCAGA 268458 15 4.68e-08 ATTGCTCTGA GGATGGGGTGGATGTGAGTGT AGATGGGAAG 262254 46 3.40e-07 GATCGCATTT GGGGTGGGAGGTTGGGTTTGC CCTTTTTCAT 269448 146 3.73e-07 GTTCTGCGGG GAGGTTGTAGGTTGGGAGGGT TGGTGGTGTG 22907 196 5.37e-07 GTTAGACGAA GCTGTGGTTGGTTTGGATGGT GTGCTTCTCC 9830 98 2.00e-06 CCCTCTGCGT GTACTTGTTGCATGTTAATGC AAGTACTCCA 9605 17 3.34e-06 GATTGAGATT CTATTTCTTGATTGAGAGTAT ATGACGACTT 5289 227 4.40e-06 CATGGACCGC ATTGTGATGTGTTGGTATTGT ACCGTGAGCT 32216 300 5.37e-06 TTAACCTCTT GGAGAGGGAGGATGAGTCGTC AAAGGATAGG 9271 108 6.94e-06 GAGCGGCGGC GTTGGCATGGGAAGTGAATGT GGGATCGGAC 8636 472 6.94e-06 AGGGACTGTG ATAGCGTTTGGATCAGATGAC ATACAAAC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 5511 1.6e-09 118_[+3]_361 1077 1.1e-08 220_[+3]_259 33454 2.9e-08 359_[+3]_120 270246 2.9e-08 238_[+3]_241 268458 4.7e-08 14_[+3]_465 262254 3.4e-07 45_[+3]_434 269448 3.7e-07 145_[+3]_334 22907 5.4e-07 195_[+3]_284 9830 2e-06 97_[+3]_382 9605 3.3e-06 16_[+3]_463 5289 4.4e-06 226_[+3]_253 32216 5.4e-06 299_[+3]_180 9271 6.9e-06 107_[+3]_372 8636 6.9e-06 471_[+3]_8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=21 seqs=14 5511 ( 119) GTGGTCGTTGGTTGAGAATGT 1 1077 ( 221) ATAGTGGTGGGATGATACTGT 1 33454 ( 360) GTATCGGTTGAATGAGTGTTT 1 270246 ( 239) GTATCGGTTGAATGAGTGTTT 1 268458 ( 15) GGATGGGGTGGATGTGAGTGT 1 262254 ( 46) GGGGTGGGAGGTTGGGTTTGC 1 269448 ( 146) GAGGTTGTAGGTTGGGAGGGT 1 22907 ( 196) GCTGTGGTTGGTTTGGATGGT 1 9830 ( 98) GTACTTGTTGCATGTTAATGC 1 9605 ( 17) CTATTTCTTGATTGAGAGTAT 1 5289 ( 227) ATTGTGATGTGTTGGTATTGT 1 32216 ( 300) GGAGAGGGAGGATGAGTCGTC 1 9271 ( 108) GTTGGCATGGGAAGTGAATGT 1 8636 ( 472) ATAGCGTTTGGATCAGATGAC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 7200 bayes= 8.92329 E= 1.1e-001 -31 -162 149 -1045 -189 -162 -25 131 110 -1045 -25 -28 -1045 -162 134 14 -189 -4 -83 114 -1045 -62 134 -28 -89 -162 149 -186 -1045 -1045 -25 160 -31 -1045 -25 114 -1045 -1045 187 -186 -31 -162 149 -1045 110 -1045 -1045 72 -189 -1045 -1045 184 -1045 -162 175 -186 91 -1045 17 -28 -1045 -1045 162 -28 143 -1045 -1045 14 -31 -62 49 14 -1045 -1045 17 146 -89 -1045 134 -28 -1045 38 -1045 146 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 14 E= 1.1e-001 0.214286 0.071429 0.714286 0.000000 0.071429 0.071429 0.214286 0.642857 0.571429 0.000000 0.214286 0.214286 0.000000 0.071429 0.642857 0.285714 0.071429 0.214286 0.142857 0.571429 0.000000 0.142857 0.642857 0.214286 0.142857 0.071429 0.714286 0.071429 0.000000 0.000000 0.214286 0.785714 0.214286 0.000000 0.214286 0.571429 0.000000 0.000000 0.928571 0.071429 0.214286 0.071429 0.714286 0.000000 0.571429 0.000000 0.000000 0.428571 0.071429 0.000000 0.000000 0.928571 0.000000 0.071429 0.857143 0.071429 0.500000 0.000000 0.285714 0.214286 0.000000 0.000000 0.785714 0.214286 0.714286 0.000000 0.000000 0.285714 0.214286 0.142857 0.357143 0.285714 0.000000 0.000000 0.285714 0.714286 0.142857 0.000000 0.642857 0.214286 0.000000 0.285714 0.000000 0.714286 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- [GA][TG][AGT][GT][TC][GT]G[TG][TAG]G[GA][AT]TG[AGT][GT][AT][GTA][TG][GT][TC] -------------------------------------------------------------------------------- Time 5.21 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 1077 4.72e-10 220_[+3(1.06e-08)]_89_\ [+2(6.33e-06)]_94_[+1(1.55e-07)]_40 21931 1.39e-06 350_[+2(2.93e-05)]_23_\ [+1(3.91e-05)]_70_[+1(1.07e-09)] 22907 3.47e-04 195_[+3(5.37e-07)]_234_\ [+2(7.35e-05)]_35 262254 3.50e-06 45_[+3(3.40e-07)]_234_\ [+2(5.89e-07)]_185 268458 2.05e-05 14_[+3(4.68e-08)]_121_\ [+2(4.61e-05)]_329 269448 3.96e-08 145_[+3(3.73e-07)]_113_\ [+1(3.13e-07)]_129_[+2(1.08e-05)]_56 270246 8.97e-11 204_[+2(2.84e-06)]_19_\ [+3(2.92e-08)]_177_[+1(2.11e-08)]_43 32216 9.08e-10 40_[+1(5.53e-08)]_202_\ [+2(7.07e-08)]_21_[+3(5.37e-06)]_180 33454 2.47e-06 325_[+2(2.84e-06)]_19_\ [+3(2.92e-08)]_120 5289 5.73e-08 226_[+3(4.40e-06)]_40_\ [+2(5.79e-06)]_159_[+1(7.42e-08)]_18 5511 5.21e-13 75_[+2(6.57e-05)]_28_[+3(1.61e-09)]_\ 253_[+1(3.85e-10)]_33_[+2(1.18e-05)]_39 8636 3.29e-04 158_[+2(1.08e-05)]_298_\ [+3(6.94e-06)]_8 9271 1.79e-04 107_[+3(6.94e-06)]_302_\ [+2(3.90e-06)]_55 9605 6.03e-09 16_[+3(3.34e-06)]_77_[+1(8.43e-09)]_\ 197_[+2(5.79e-06)]_153 9830 6.17e-11 97_[+3(2.00e-06)]_60_[+2(2.29e-06)]_\ 8_[+1(2.55e-10)]_278 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 3 reached. ******************************************************************************** CPU: seaotter.hsd1.wa.comcast.net ********************************************************************************