******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.10.0 (Release date: Wed May 21 10:35:36 2014 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= motifs/8/8.seqs.fa ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ 1088 1.0000 500 1116 1.0000 500 11646 1.0000 500 11661 1.0000 500 11851 1.0000 500 1761 1.0000 500 1934 1.0000 500 25033 1.0000 500 25692 1.0000 500 270309 1.0000 500 2874 1.0000 500 3270 1.0000 500 34265 1.0000 500 36641 1.0000 500 37640 1.0000 500 38707 1.0000 500 4612 1.0000 500 6983 1.0000 500 8806 1.0000 500 bd989 1.0000 500 ThpsCp035 1.0000 500 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme motifs/8/8.seqs.fa -oc motifs/8 -dna -minw 12 -maxw 21 -nmotifs 3 -maxsize 500000 model: mod= zoops nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 12 maxw= 21 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 2 maxsites= 21 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 global: substring= yes branching= no wbranch= no em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 10500 N= 21 strands: + sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.276 C 0.221 G 0.221 T 0.283 Background letter frequencies (from dataset with add-one prior applied): A 0.276 C 0.221 G 0.221 T 0.283 ******************************************************************************** ******************************************************************************** MOTIF 1 MEME width = 21 sites = 19 llr = 249 E-value = 3.4e-014 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A 62:761525427171175475 pos.-specific C 287149143252838923533 probability G ::::::2:2:3::::::1112 matrix T 2:32::24:5:11:1:11::: bits 2.2 2.0 * 1.7 * * 1.5 * * * Relative 1.3 ** * * ** Entropy 1.1 ** ** **** (18.9 bits) 0.9 ** ** ****** * 0.7 ****** ******* *** 0.4 ****** ************** 0.2 ********************* 0.0 --------------------- Multilevel ACCAACATATCACACCAACAA consensus C TTC TCCAGC C CACC sequence AG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 38707 247 4.42e-11 ATGCTGCTGA ACCAACATATGACACCAAAAA GACTCCGTAT 36641 247 4.42e-11 ATGCTGCTGA ACCAACATATGACACCAAAAA GACTCCGTAT 270309 248 4.42e-11 ATGCTGCTGA ACCAACATATGACACCAAAAA GACTCCGTAT 11661 248 4.42e-11 ATGCTGCTGA ACCAACATATGACACCAAAAA GACTCCGTAT 37640 457 4.27e-10 ACACCTCACT ACCAACACCAAACACCAACAA CCACACACTC 1761 479 1.08e-08 AGTGACCTCA CCCACCACAACACACAAACAC C 6983 422 6.71e-08 CCTTCTCCCC ACCACCACATCCAACCAACCG TTAAAGATAC 4612 458 1.40e-07 AACGCAACAA CACACCCAAACACACCACCAC CACGTGCACT 1116 375 7.89e-07 GGTACCTCCT ACCACCAACCGAAACCACGCA TCCACCAAAG 2874 478 1.01e-06 CCCACCTTAC ACCTCCTTGCCACACAACACA AC 8806 475 1.85e-06 ACTGCATTCG ACCTCCACATCATCACCACAA CGCTA 11851 438 2.14e-06 CAACTGGACC TCTTCATCATCACACCAACCA CTAACTAAGG 25692 434 2.64e-06 GTTGAACGGA ACTCACTAAACCCACCTCAAC AACCATGTCG ThpsCp035 170 3.96e-06 TTTTGAGTTA AATAACGTGAAACCCCAGCAG AACGTTTATT bd989 171 3.96e-06 TTTTGAGTTA AATAACGTGAAACCCCAGCAG AACGTTTATT 34265 220 4.80e-06 GGGACACCCC TCCAACAAGAGTCACCCCGAC GGCAGCTGCA 11646 396 7.81e-06 AACGCTTATC CCTAACGCCCCCCCCCCTCCA CCATTCATTC 1934 349 9.29e-06 CTTCGAAACT CCCCCCCTCTCACCTCAACGC CTCCAATGAT 25033 461 1.04e-05 CTGCGAGCAG TCCTACTCCTCCCCACTCAAC AACTCAGATA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 38707 4.4e-11 246_[+1]_233 36641 4.4e-11 246_[+1]_233 270309 4.4e-11 247_[+1]_232 11661 4.4e-11 247_[+1]_232 37640 4.3e-10 456_[+1]_23 1761 1.1e-08 478_[+1]_1 6983 6.7e-08 421_[+1]_58 4612 1.4e-07 457_[+1]_22 1116 7.9e-07 374_[+1]_105 2874 1e-06 477_[+1]_2 8806 1.8e-06 474_[+1]_5 11851 2.1e-06 437_[+1]_42 25692 2.6e-06 433_[+1]_46 ThpsCp035 4e-06 169_[+1]_310 bd989 4e-06 170_[+1]_309 34265 4.8e-06 219_[+1]_260 11646 7.8e-06 395_[+1]_84 1934 9.3e-06 348_[+1]_131 25033 1e-05 460_[+1]_19 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=21 seqs=19 38707 ( 247) ACCAACATATGACACCAAAAA 1 36641 ( 247) ACCAACATATGACACCAAAAA 1 270309 ( 248) ACCAACATATGACACCAAAAA 1 11661 ( 248) ACCAACATATGACACCAAAAA 1 37640 ( 457) ACCAACACCAAACACCAACAA 1 1761 ( 479) CCCACCACAACACACAAACAC 1 6983 ( 422) ACCACCACATCCAACCAACCG 1 4612 ( 458) CACACCCAAACACACCACCAC 1 1116 ( 375) ACCACCAACCGAAACCACGCA 1 2874 ( 478) ACCTCCTTGCCACACAACACA 1 8806 ( 475) ACCTCCACATCATCACCACAA 1 11851 ( 438) TCTTCATCATCACACCAACCA 1 25692 ( 434) ACTCACTAAACCCACCTCAAC 1 ThpsCp035 ( 170) AATAACGTGAAACCCCAGCAG 1 bd989 ( 171) AATAACGTGAAACCCCAGCAG 1 34265 ( 220) TCCAACAAGAGTCACCCCGAC 1 11646 ( 396) CCTAACGCCCCCCCCCCTCCA 1 1934 ( 349) CCCCCCCTCTCACCTCAACGC 1 25033 ( 461) TCCTACTCCTCCCCACTCAAC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 10080 bayes= 9.94725 E= 3.4e-014 119 -7 -1089 -84 -81 193 -1089 -1089 -1089 174 -1089 -10 131 -107 -1089 -42 107 93 -1089 -1089 -239 210 -1089 -1089 93 -107 -48 -42 -39 74 -1089 58 93 25 -7 -1089 42 -48 -1089 75 -81 125 52 -1089 142 -7 -1089 -242 -139 193 -1089 -242 131 52 -1089 -1089 -139 193 -1089 -242 -139 202 -1089 -1089 142 -48 -1089 -142 93 52 -107 -242 42 125 -107 -1089 131 25 -207 -1089 93 52 -48 -1089 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 19 E= 3.4e-014 0.631579 0.210526 0.000000 0.157895 0.157895 0.842105 0.000000 0.000000 0.000000 0.736842 0.000000 0.263158 0.684211 0.105263 0.000000 0.210526 0.578947 0.421053 0.000000 0.000000 0.052632 0.947368 0.000000 0.000000 0.526316 0.105263 0.157895 0.210526 0.210526 0.368421 0.000000 0.421053 0.526316 0.263158 0.210526 0.000000 0.368421 0.157895 0.000000 0.473684 0.157895 0.526316 0.315789 0.000000 0.736842 0.210526 0.000000 0.052632 0.105263 0.842105 0.000000 0.052632 0.684211 0.315789 0.000000 0.000000 0.105263 0.842105 0.000000 0.052632 0.105263 0.894737 0.000000 0.000000 0.736842 0.157895 0.000000 0.105263 0.526316 0.315789 0.105263 0.052632 0.368421 0.526316 0.105263 0.000000 0.684211 0.263158 0.052632 0.000000 0.526316 0.315789 0.157895 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- [AC]C[CT][AT][AC]C[AT][TCA][ACG][TA][CG][AC]C[AC]CCA[AC][CA][AC][AC] -------------------------------------------------------------------------------- Time 3.84 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 MEME width = 21 sites = 9 llr = 174 E-value = 3.7e-012 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A :::8:::1::9::94:4::2: pos.-specific C :7a::8::1:::612::2:1a probability G :1:21:a:991:1::73617: matrix T a2::92:9:1:a3:33229:: bits 2.2 * * * 2.0 * * * 1.7 * * * ** * * 1.5 * * * ** * * Relative 1.3 * * ******** * * * Entropy 1.1 * ********** * * * * (27.9 bits) 0.9 ************ * * *** 0.7 ************** * **** 0.4 ********************* 0.2 ********************* 0.0 --------------------- Multilevel TCCATCGTGGATCAAGAGTGC consensus T G T T TTGC A sequence C TT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 38707 2 1.79e-13 A TCCATCGTGGATCAAGAGTGC TGCAACTCGT 36641 2 1.79e-13 A TCCATCGTGGATCAAGAGTGC TGCAACTCGT 270309 3 1.79e-13 CA TCCATCGTGGATCAAGAGTGC TGCAACTCGT 11661 3 1.79e-13 CA TCCATCGTGGATCAAGAGTGC TGCAACTCGT ThpsCp035 134 7.49e-09 TTAAGTTCCA TCCGTTGTGGATTATTTCTAC GATTTTTTTG bd989 135 7.49e-09 TTAAGTTCCA TCCGTTGTGGATTATTTCTAC GATTTTTTTG 6983 233 1.15e-08 TTCGTTGATA TTCATCGTGGGTTCCGGGGGC AAAGAGTAAA 25692 11 1.69e-08 TGCACAAGAC TGCAGCGTCGATGATGGTTGC TCCAACGTCA 1934 393 3.28e-08 GAGCTCCTTA TTCATCGAGTATCACTGTTCC AGCGGGAAAA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 38707 1.8e-13 1_[+2]_478 36641 1.8e-13 1_[+2]_478 270309 1.8e-13 2_[+2]_477 11661 1.8e-13 2_[+2]_477 ThpsCp035 7.5e-09 133_[+2]_346 bd989 7.5e-09 134_[+2]_345 6983 1.1e-08 232_[+2]_247 25692 1.7e-08 10_[+2]_469 1934 3.3e-08 392_[+2]_87 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=21 seqs=9 38707 ( 2) TCCATCGTGGATCAAGAGTGC 1 36641 ( 2) TCCATCGTGGATCAAGAGTGC 1 270309 ( 3) TCCATCGTGGATCAAGAGTGC 1 11661 ( 3) TCCATCGTGGATCAAGAGTGC 1 ThpsCp035 ( 134) TCCGTTGTGGATTATTTCTAC 1 bd989 ( 135) TCCGTTGTGGATTATTTCTAC 1 6983 ( 233) TTCATCGTGGGTTCCGGGGGC 1 25692 ( 11) TGCAGCGTCGATGATGGTTGC 1 1934 ( 393) TTCATCGAGTATCACTGTTCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 10080 bayes= 10.2624 E= 3.7e-012 -982 -982 -982 182 -982 159 -99 -35 -982 218 -982 -982 149 -982 1 -982 -982 -982 -99 165 -982 182 -982 -35 -982 -982 218 -982 -131 -982 -982 165 -982 -99 201 -982 -982 -982 201 -134 169 -982 -99 -982 -982 -982 -982 182 -982 133 -99 24 169 -99 -982 -982 69 1 -982 24 -982 -982 159 24 69 -982 59 -35 -982 1 133 -35 -982 -982 -99 165 -31 -99 159 -982 -982 218 -982 -982 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 9 E= 3.7e-012 0.000000 0.000000 0.000000 1.000000 0.000000 0.666667 0.111111 0.222222 0.000000 1.000000 0.000000 0.000000 0.777778 0.000000 0.222222 0.000000 0.000000 0.000000 0.111111 0.888889 0.000000 0.777778 0.000000 0.222222 0.000000 0.000000 1.000000 0.000000 0.111111 0.000000 0.000000 0.888889 0.000000 0.111111 0.888889 0.000000 0.000000 0.000000 0.888889 0.111111 0.888889 0.000000 0.111111 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.555556 0.111111 0.333333 0.888889 0.111111 0.000000 0.000000 0.444444 0.222222 0.000000 0.333333 0.000000 0.000000 0.666667 0.333333 0.444444 0.000000 0.333333 0.222222 0.000000 0.222222 0.555556 0.222222 0.000000 0.000000 0.111111 0.888889 0.222222 0.111111 0.666667 0.000000 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- T[CT]C[AG]T[CT]GTGGAT[CT]A[ATC][GT][AGT][GCT]T[GA]C -------------------------------------------------------------------------------- Time 7.41 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 MEME width = 21 sites = 6 llr = 145 E-value = 1.8e-012 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A :a:82a:a:::3:8a72:::: pos.-specific C ::::::::::::8::3::a8: probability G 3:a28:2:::a722::8a:2a matrix T 7:::::8:aa::::::::::: bits 2.2 * * ** * 2.0 ** * * * * ** * 1.7 ** * **** * ** * 1.5 ** ** **** * * ***** Relative 1.3 ********** *** ***** Entropy 1.1 ********************* (35.0 bits) 0.9 ********************* 0.7 ********************* 0.4 ********************* 0.2 ********************* 0.0 --------------------- Multilevel TAGAGATATTGGCAAAGGCCG consensus G A C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 38707 77 2.17e-13 TGCTTGTTGA TAGAGATATTGGCAAAGGCCG TAGTTCTTGA 36641 77 2.17e-13 TGCTTGTTGA TAGAGATATTGGCAAAGGCCG TAGTTCTTGA 270309 78 2.17e-13 TGCTTGTTGA TAGAGATATTGGCAAAGGCCG TAGTTCTTGA 11661 78 2.17e-13 TGCTTGTTGA TAGAGATATTGGCAAAGGCCG TAGTTCTTGA 1116 89 1.05e-10 CGTCAGGCGA GAGAGATATTGACGACAGCGG TCGCGAAGAA 1761 320 1.70e-10 CAGTGTAGCA GAGGAAGATTGAGAACGGCCG TTCGAGGAAG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 38707 2.2e-13 76_[+3]_403 36641 2.2e-13 76_[+3]_403 270309 2.2e-13 77_[+3]_402 11661 2.2e-13 77_[+3]_402 1116 1.1e-10 88_[+3]_391 1761 1.7e-10 319_[+3]_160 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=21 seqs=6 38707 ( 77) TAGAGATATTGGCAAAGGCCG 1 36641 ( 77) TAGAGATATTGGCAAAGGCCG 1 270309 ( 78) TAGAGATATTGGCAAAGGCCG 1 11661 ( 78) TAGAGATATTGGCAAAGGCCG 1 1116 ( 89) GAGAGATATTGACGACAGCGG 1 1761 ( 320) GAGGAAGATTGAGAACGGCCG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 10080 bayes= 10.3721 E= 1.8e-012 -923 -923 59 124 186 -923 -923 -923 -923 -923 218 -923 159 -923 -41 -923 -73 -923 191 -923 186 -923 -923 -923 -923 -923 -41 156 186 -923 -923 -923 -923 -923 -923 182 -923 -923 -923 182 -923 -923 218 -923 27 -923 159 -923 -923 192 -41 -923 159 -923 -41 -923 186 -923 -923 -923 127 59 -923 -923 -73 -923 191 -923 -923 -923 218 -923 -923 218 -923 -923 -923 192 -41 -923 -923 -923 218 -923 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 6 E= 1.8e-012 0.000000 0.000000 0.333333 0.666667 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.833333 0.000000 0.166667 0.000000 0.166667 0.000000 0.833333 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.833333 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.333333 0.000000 0.666667 0.000000 0.000000 0.833333 0.166667 0.000000 0.833333 0.000000 0.166667 0.000000 1.000000 0.000000 0.000000 0.000000 0.666667 0.333333 0.000000 0.000000 0.166667 0.000000 0.833333 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.833333 0.166667 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- [TG]AGAGATATTG[GA]CAA[AC]GGCCG -------------------------------------------------------------------------------- Time 10.98 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 1088 1.50e-02 179_[+2(9.97e-05)]_53_\ [+3(3.66e-05)]_226 1116 7.95e-10 88_[+3(1.05e-10)]_265_\ [+1(7.89e-07)]_105 11646 1.70e-02 395_[+1(7.81e-06)]_84 11661 3.99e-25 2_[+2(1.79e-13)]_54_[+3(2.17e-13)]_\ 149_[+1(4.42e-11)]_232 11851 1.35e-02 437_[+1(2.14e-06)]_42 1761 4.60e-11 319_[+3(1.70e-10)]_138_\ [+1(1.08e-08)]_1 1934 7.10e-06 348_[+1(9.29e-06)]_23_\ [+2(3.28e-08)]_87 25033 1.59e-02 460_[+1(1.04e-05)]_19 25692 7.49e-08 10_[+2(1.69e-08)]_297_\ [+3(5.82e-05)]_84_[+1(2.64e-06)]_46 270309 3.99e-25 2_[+2(1.79e-13)]_54_[+3(2.17e-13)]_\ 149_[+1(4.42e-11)]_232 2874 7.94e-03 477_[+1(1.01e-06)]_2 3270 1.42e-01 500 34265 2.86e-03 198_[+3(8.71e-05)]_[+1(4.80e-06)]_\ 260 36641 3.99e-25 1_[+2(1.79e-13)]_54_[+3(2.17e-13)]_\ 149_[+1(4.42e-11)]_233 37640 3.41e-06 456_[+1(4.27e-10)]_23 38707 3.99e-25 1_[+2(1.79e-13)]_54_[+3(2.17e-13)]_\ 149_[+1(4.42e-11)]_233 4612 1.86e-04 457_[+1(1.40e-07)]_22 6983 1.58e-08 232_[+2(1.15e-08)]_168_\ [+1(6.71e-08)]_58 8806 2.32e-02 474_[+1(1.85e-06)]_5 bd989 1.29e-06 134_[+2(7.49e-09)]_15_\ [+1(3.96e-06)]_309 ThpsCp035 1.29e-06 133_[+2(7.49e-09)]_15_\ [+1(3.96e-06)]_310 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 3 reached. ******************************************************************************** CPU: seaotter.hsd1.wa.comcast.net ********************************************************************************