******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.10.0 (Release date: Wed May 21 10:35:36 2014 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= motifs/89/89.seqs.fa ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ 11166 1.0000 500 12846 1.0000 500 22374 1.0000 500 2415 1.0000 500 260768 1.0000 500 260772 1.0000 500 261357 1.0000 500 262611 1.0000 500 264043 1.0000 500 264676 1.0000 500 268060 1.0000 500 35197 1.0000 500 35501 1.0000 500 35544 1.0000 500 37158 1.0000 500 596 1.0000 500 6224 1.0000 500 bd137 1.0000 500 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme motifs/89/89.seqs.fa -oc motifs/89 -dna -minw 12 -maxw 21 -nmotifs 3 -maxsize 500000 model: mod= zoops nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 12 maxw= 21 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 2 maxsites= 18 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 global: substring= yes branching= no wbranch= no em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 9000 N= 18 strands: + sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.277 C 0.236 G 0.242 T 0.246 Background letter frequencies (from dataset with add-one prior applied): A 0.277 C 0.236 G 0.242 T 0.246 ******************************************************************************** ******************************************************************************** MOTIF 1 MEME width = 21 sites = 14 llr = 190 E-value = 3.6e-005 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A 1:493181443361623342: pos.-specific C 42:1:12::2:12:2:::2:: probability G 176:77:9647619184725a matrix T 41::::::1:::1:1:3:13: bits 2.1 * 1.9 * 1.7 * * * 1.5 * * * * Relative 1.3 * ** * * * Entropy 1.0 **** ** * * * * * (19.6 bits) 0.8 ******* ** * * * * 0.6 ******** ** * * * * 0.4 ****************** ** 0.2 ****************** ** 0.0 --------------------- Multilevel CGGAGGAGGGGGAGAGGGAGG consensus TCA A C AAAAC CAAACT sequence C T GA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 261357 211 1.52e-09 ACTCGTCCTA CGGAGGAGAGGGCGAGTGTGG ATGATGTTTG 2415 210 1.52e-09 ACTCGTCCTA CGGAGGAGAGGGCGAGTGTGG ATGATGTTTG 35501 25 1.77e-09 AAGATTAAAG TGAAGGAGGAGGAGCGAGAAG CATTGGTCAA 12846 154 7.74e-09 GGGAAGAACA TCAAGGAGGGGGGGAGTGATG ATGAGAGTGG bd137 7 6.63e-08 GGTGAG TTGAGGAGGCGGAGCGGGGAG GGCTTGTGAG 268060 223 6.63e-08 AAGCTGGTCT CGGAAGAGAGACAGAGGGCGG GGGAGAACAC 264043 377 1.10e-07 ACTAATGTTT CGGAGGAAGAGAAGAAGGATG GTGTGTTAGT 35197 210 3.31e-07 GATTCTGAAT TCGAGCCGGAGGAGAGTACTG CAGCCGAGTT 35544 426 1.06e-06 GCATGATTGA GCGAGGCGAGGGGGGGGAAGG AGCCAACGAC 11166 119 1.22e-06 ACAACACTCT TGACGGAGGCAGAAAGAGGGG ATAACAAAAG 596 294 1.31e-06 ACCAACAGTT CGAAGACGACGACGAGGAAAG CACTAGAAGT 264676 244 1.70e-06 ATCCACCTTG CGGAACAGGAGAAGTAGACGG ACTGATAGAG 260768 16 3.32e-06 GGCTGCAGAG AGAAAGAGGAAGTGGAAGAGG AACAACCCAG 37158 449 3.72e-06 TTATTTTTAG TGAAAAAGTGAAAGCGAGGTG ATATCATTCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 261357 1.5e-09 210_[+1]_269 2415 1.5e-09 209_[+1]_270 35501 1.8e-09 24_[+1]_455 12846 7.7e-09 153_[+1]_326 bd137 6.6e-08 6_[+1]_473 268060 6.6e-08 222_[+1]_257 264043 1.1e-07 376_[+1]_103 35197 3.3e-07 209_[+1]_270 35544 1.1e-06 425_[+1]_54 11166 1.2e-06 118_[+1]_361 596 1.3e-06 293_[+1]_186 264676 1.7e-06 243_[+1]_236 260768 3.3e-06 15_[+1]_464 37158 3.7e-06 448_[+1]_31 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=21 seqs=14 261357 ( 211) CGGAGGAGAGGGCGAGTGTGG 1 2415 ( 210) CGGAGGAGAGGGCGAGTGTGG 1 35501 ( 25) TGAAGGAGGAGGAGCGAGAAG 1 12846 ( 154) TCAAGGAGGGGGGGAGTGATG 1 bd137 ( 7) TTGAGGAGGCGGAGCGGGGAG 1 268060 ( 223) CGGAAGAGAGACAGAGGGCGG 1 264043 ( 377) CGGAGGAAGAGAAGAAGGATG 1 35197 ( 210) TCGAGCCGGAGGAGAGTACTG 1 35544 ( 426) GCGAGGCGAGGGGGGGGAAGG 1 11166 ( 119) TGACGGAGGCAGAAAGAGGGG 1 596 ( 294) CGAAGACGACGACGAGGAAAG 1 264676 ( 244) CGGAACAGGAGAAGTAGACGG 1 260768 ( 16) AGAAAGAGGAAGTGGAAGAGG 1 37158 ( 449) TGAAAAAGTGAAAGCGAGGTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 8640 bayes= 9.87364 E= 3.6e-005 -195 86 -176 80 -1045 -14 156 -178 63 -1045 124 -1045 175 -172 -1045 -1045 5 -1045 156 -1045 -95 -72 156 -1045 151 -14 -1045 -1045 -195 -1045 194 -1045 37 -1045 124 -178 37 -14 83 -1045 5 -1045 156 -1045 5 -172 141 -1045 105 -14 -76 -178 -195 -1045 194 -1045 105 -14 -76 -178 -37 -1045 170 -1045 5 -1045 83 22 5 -1045 156 -1045 63 -14 -17 -78 -37 -1045 105 22 -1045 -1045 205 -1045 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 14 E= 3.6e-005 0.071429 0.428571 0.071429 0.428571 0.000000 0.214286 0.714286 0.071429 0.428571 0.000000 0.571429 0.000000 0.928571 0.071429 0.000000 0.000000 0.285714 0.000000 0.714286 0.000000 0.142857 0.142857 0.714286 0.000000 0.785714 0.214286 0.000000 0.000000 0.071429 0.000000 0.928571 0.000000 0.357143 0.000000 0.571429 0.071429 0.357143 0.214286 0.428571 0.000000 0.285714 0.000000 0.714286 0.000000 0.285714 0.071429 0.642857 0.000000 0.571429 0.214286 0.142857 0.071429 0.071429 0.000000 0.928571 0.000000 0.571429 0.214286 0.142857 0.071429 0.214286 0.000000 0.785714 0.000000 0.285714 0.000000 0.428571 0.285714 0.285714 0.000000 0.714286 0.000000 0.428571 0.214286 0.214286 0.142857 0.214286 0.000000 0.500000 0.285714 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- [CT][GC][GA]A[GA]G[AC]G[GA][GAC][GA][GA][AC]G[AC][GA][GAT][GA][ACG][GTA]G -------------------------------------------------------------------------------- Time 2.82 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 MEME width = 12 sites = 18 llr = 170 E-value = 5.4e-004 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A :82:4::6:1:2 pos.-specific C 9::732a1313: probability G 11::1::2::7: matrix T :18328:27918 bits 2.1 * 1.9 * 1.7 * * 1.5 * * * Relative 1.3 * ** ** ** * Entropy 1.0 * ** ** ** * (13.6 bits) 0.8 **** ** **** 0.6 **** ** **** 0.4 **** ******* 0.2 ************ 0.0 ------------ Multilevel CATCATCATTGT consensus TCC GC CA sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ------------ 261357 142 2.79e-07 GATGCACCAT CATCATCGTTGT CGTTGACGAC 2415 141 2.79e-07 GATGCACCAT CATCATCGTTGT CGTTGACGAC 11166 262 2.79e-07 TATCAACCGC CATCTTCATTGT CGGCACCAAC 264043 142 2.00e-06 CCACCCCCAC CATCCTCACTCT ACGCAATATC 12846 297 3.23e-06 GTTGTGAGTG CATTGTCATTGT GATTCGATAA 260768 180 6.07e-06 GCCTTTAGTA CATCCTCGCTCT TTGAAGGAAC 35501 416 8.90e-06 GGACGGACCT CAACACCATTGT CTACCACGGG 596 194 1.43e-05 AGAGCAGTGT CTTCATCACTCT TTCATGGTGT bd137 143 1.55e-05 TTGTTATCCC CTTTTTCATTGT AACGACGACG 6224 5 1.84e-05 CTCC CATTCTCTTTGA AACTGGTCTG 37158 272 2.27e-05 TAAGGATTCA CATCCTCATACT CTTGACTACA 22374 181 2.27e-05 CTGCAAATGA CAACACCACTGT ACCCTCGGCT 260772 215 6.58e-05 TTCCAGCTGT CGTCGTCCTTGT GTTGGTCTCT 35544 141 7.08e-05 GTTTCTTCCG CGTCTTCATCGT CATCACGTCG 268060 75 7.51e-05 GTGGATGGTT GATTATCGTTGA TAGGTGCATA 262611 255 7.95e-05 GCCAGGCCAT CAACCTCACTTT CCAGTGCAGT 264676 19 8.52e-05 CTCTTCTACG CATTACCTTTCA GAATCCCGAG 35197 262 1.09e-04 ACGGAGAAAA GATCACCTTTGA AAGTCGCCAC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 261357 2.8e-07 141_[+2]_347 2415 2.8e-07 140_[+2]_348 11166 2.8e-07 261_[+2]_227 264043 2e-06 141_[+2]_347 12846 3.2e-06 296_[+2]_192 260768 6.1e-06 179_[+2]_309 35501 8.9e-06 415_[+2]_73 596 1.4e-05 193_[+2]_295 bd137 1.6e-05 142_[+2]_346 6224 1.8e-05 4_[+2]_484 37158 2.3e-05 271_[+2]_217 22374 2.3e-05 180_[+2]_308 260772 6.6e-05 214_[+2]_274 35544 7.1e-05 140_[+2]_348 268060 7.5e-05 74_[+2]_414 262611 7.9e-05 254_[+2]_234 264676 8.5e-05 18_[+2]_470 35197 0.00011 261_[+2]_227 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=12 seqs=18 261357 ( 142) CATCATCGTTGT 1 2415 ( 141) CATCATCGTTGT 1 11166 ( 262) CATCTTCATTGT 1 264043 ( 142) CATCCTCACTCT 1 12846 ( 297) CATTGTCATTGT 1 260768 ( 180) CATCCTCGCTCT 1 35501 ( 416) CAACACCATTGT 1 596 ( 194) CTTCATCACTCT 1 bd137 ( 143) CTTTTTCATTGT 1 6224 ( 5) CATTCTCTTTGA 1 37158 ( 272) CATCCTCATACT 1 22374 ( 181) CAACACCACTGT 1 260772 ( 215) CGTCGTCCTTGT 1 35544 ( 141) CGTCTTCATCGT 1 268060 ( 75) GATTATCGTTGA 1 262611 ( 255) CAACCTCACTTT 1 264676 ( 19) CATTACCTTTCA 1 35197 ( 262) GATCACCTTTGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 8802 bayes= 8.93074 E= 5.4e-004 -1081 191 -112 -1081 149 -1081 -112 -115 -73 -1081 -1081 176 -1081 161 -1081 17 68 24 -112 -56 -1081 -9 -1081 166 -1081 208 -1081 -1081 101 -208 -12 -56 -1081 24 -1081 155 -231 -208 -1081 185 -1081 24 146 -214 -32 -1081 -1081 166 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 18 E= 5.4e-004 0.000000 0.888889 0.111111 0.000000 0.777778 0.000000 0.111111 0.111111 0.166667 0.000000 0.000000 0.833333 0.000000 0.722222 0.000000 0.277778 0.444444 0.277778 0.111111 0.166667 0.000000 0.222222 0.000000 0.777778 0.000000 1.000000 0.000000 0.000000 0.555556 0.055556 0.222222 0.166667 0.000000 0.277778 0.000000 0.722222 0.055556 0.055556 0.000000 0.888889 0.000000 0.277778 0.666667 0.055556 0.222222 0.000000 0.000000 0.777778 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- CAT[CT][AC][TC]C[AG][TC]T[GC][TA] -------------------------------------------------------------------------------- Time 5.61 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 MEME width = 16 sites = 10 llr = 136 E-value = 7.5e-002 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A ::4:::::1:5:212: pos.-specific C :3::215::3:749:9 probability G 9::85:51:::3:::1 matrix T 176239:9975:4:8: bits 2.1 1.9 1.7 * * * 1.5 * * ** * * Relative 1.3 ** * * *** * *** Entropy 1.0 **** ******* *** (19.6 bits) 0.8 **** ******* *** 0.6 ************ *** 0.4 **************** 0.2 **************** 0.0 ---------------- Multilevel GTTGGTCTTTACCCTC consensus CATT G CTGT A sequence C A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ---------------- 22374 387 5.76e-10 AGTAGCAGTC GTTGGTCTTTTCCCTC TACACCAATG 261357 13 1.07e-08 TACTTTTTAC GTAGTTGTTTACTCTC CTTGTCAGAC 2415 12 1.07e-08 TACTTTTTAC GTAGTTGTTTACTCTC CTTGTCAGAC 260772 138 3.18e-08 CTGCCGATGT GTTGCTGTTCACTCTC TGTCCTTTGC 35501 257 2.95e-07 AAAACAATGC TTTTGTCTTTTCTCTC TCTCATATCA 596 421 5.88e-07 TTGAGCTCGC GTAGGCCTTCACACTC GTCTTGTGTC 11166 471 8.38e-07 CTCCACAGCT GCTGCTCTTCTGCCAC CACTGTACAA 260768 49 1.28e-06 CAACCCAGAT GCTGGTCGTTACACAC CGAGTGGGCA 35544 304 1.85e-06 GACTCTCTGC GCATGTGTATTGCCTC TTTGTGATGT 12846 319 2.14e-06 GATTCGATAA GTTGTTGTTTTGCATG TATTGTCGTG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 22374 5.8e-10 386_[+3]_98 261357 1.1e-08 12_[+3]_472 2415 1.1e-08 11_[+3]_473 260772 3.2e-08 137_[+3]_347 35501 3e-07 256_[+3]_228 596 5.9e-07 420_[+3]_64 11166 8.4e-07 470_[+3]_14 260768 1.3e-06 48_[+3]_436 35544 1.8e-06 303_[+3]_181 12846 2.1e-06 318_[+3]_166 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=16 seqs=10 22374 ( 387) GTTGGTCTTTTCCCTC 1 261357 ( 13) GTAGTTGTTTACTCTC 1 2415 ( 12) GTAGTTGTTTACTCTC 1 260772 ( 138) GTTGCTGTTCACTCTC 1 35501 ( 257) TTTTGTCTTTTCTCTC 1 596 ( 421) GTAGGCCTTCACACTC 1 11166 ( 471) GCTGCTCTTCTGCCAC 1 260768 ( 49) GCTGGTCGTTACACAC 1 35544 ( 304) GCATGTGTATTGCCTC 1 12846 ( 319) GTTGTTGTTTTGCATG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 16 n= 8730 bayes= 10.02 E= 7.5e-002 -997 -997 190 -130 -997 35 -997 151 53 -997 -997 128 -997 -997 173 -30 -997 -24 105 29 -997 -124 -997 187 -997 108 105 -997 -997 -997 -127 187 -146 -997 -997 187 -997 35 -997 151 85 -997 -997 102 -997 157 31 -997 -47 76 -997 70 -146 193 -997 -997 -47 -997 -997 170 -997 193 -127 -997 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 16 nsites= 10 E= 7.5e-002 0.000000 0.000000 0.900000 0.100000 0.000000 0.300000 0.000000 0.700000 0.400000 0.000000 0.000000 0.600000 0.000000 0.000000 0.800000 0.200000 0.000000 0.200000 0.500000 0.300000 0.000000 0.100000 0.000000 0.900000 0.000000 0.500000 0.500000 0.000000 0.000000 0.000000 0.100000 0.900000 0.100000 0.000000 0.000000 0.900000 0.000000 0.300000 0.000000 0.700000 0.500000 0.000000 0.000000 0.500000 0.000000 0.700000 0.300000 0.000000 0.200000 0.400000 0.000000 0.400000 0.100000 0.900000 0.000000 0.000000 0.200000 0.000000 0.000000 0.800000 0.000000 0.900000 0.100000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- G[TC][TA][GT][GTC]T[CG]TT[TC][AT][CG][CTA]C[TA]C -------------------------------------------------------------------------------- Time 8.47 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 11166 1.03e-08 118_[+1(1.22e-06)]_122_\ [+2(2.79e-07)]_197_[+3(8.38e-07)]_14 12846 2.20e-09 153_[+1(7.74e-09)]_18_\ [+1(5.84e-05)]_83_[+2(3.23e-06)]_10_[+3(2.14e-06)]_166 22374 2.48e-07 180_[+2(2.27e-05)]_194_\ [+3(5.76e-10)]_55_[+3(6.98e-05)]_27 2415 3.41e-13 11_[+3(1.07e-08)]_113_\ [+2(2.79e-07)]_57_[+1(1.52e-09)]_270 260768 6.27e-07 15_[+1(3.32e-06)]_12_[+3(1.28e-06)]_\ 115_[+2(6.07e-06)]_309 260772 3.77e-05 137_[+3(3.18e-08)]_61_\ [+2(6.58e-05)]_5_[+3(8.77e-05)]_142_[+3(7.80e-05)]_95 261357 3.41e-13 12_[+3(1.07e-08)]_113_\ [+2(2.79e-07)]_57_[+1(1.52e-09)]_269 262611 2.63e-01 254_[+2(7.95e-05)]_234 264043 3.71e-06 141_[+2(2.00e-06)]_223_\ [+1(1.10e-07)]_103 264676 1.82e-03 18_[+2(8.52e-05)]_213_\ [+1(1.70e-06)]_236 268060 8.33e-05 51_[+1(8.86e-05)]_2_[+2(7.51e-05)]_\ 136_[+1(6.63e-08)]_257 35197 1.92e-04 209_[+1(3.31e-07)]_270 35501 2.27e-10 24_[+1(1.77e-09)]_211_\ [+3(2.95e-07)]_143_[+2(8.90e-06)]_73 35544 2.80e-06 140_[+2(7.08e-05)]_151_\ [+3(1.85e-06)]_106_[+1(1.06e-06)]_54 37158 2.19e-04 271_[+2(2.27e-05)]_165_\ [+1(3.72e-06)]_31 596 2.88e-07 193_[+2(1.43e-05)]_88_\ [+1(1.31e-06)]_106_[+3(5.88e-07)]_64 6224 3.80e-02 4_[+2(1.84e-05)]_484 bd137 2.83e-05 6_[+1(6.63e-08)]_115_[+2(1.55e-05)]_\ 346 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 3 reached. ******************************************************************************** CPU: seaotter.hsd1.wa.comcast.net ********************************************************************************