GO:0004662

CAAX-protein geranylgeranyltransferase activity

Details: 
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
GO Category: 
MF
Trans_IPPS_HT
PT_UbiA_COQ2
(GGPS5) Trans_IPPS_HT
Trans_IPPS_HH
(GGTB1) PLN03201
FTase
BET4
PT_UbiA_Cox10