Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU0107 glnH

glutamine ABC transporter periplasmic glutamine-binding protein

CircVis
Functional Annotations (7)
Function System
ABC-type amino acid transport/signal transduction systems, periplasmic component/domain cog/ cog
ionotropic glutamate receptor activity go/ molecular_function
extracellular-glutamate-gated ion channel activity go/ molecular_function
transport go/ biological_process
membrane go/ cellular_component
outer membrane-bounded periplasmic space go/ cellular_component
ABC transporters kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU0107
(Mouseover regulator name to see its description)

DVU0107 is regulated by 18 influences and regulates 0 modules.
Regulators for DVU0107 glnH (18)
Regulator Module Operator
DVU0936
DVU2275
221 combiner
DVU1419 221 tf
DVU1628
DVU1340
221 combiner
DVU1949 221 tf
DVU2275 221 tf
DVU2547
DVU2588
221 combiner
DVU2547
DVU2832
221 combiner
DVU3167 221 tf
DVU3381 221 tf
DVUA0024
DVU1628
221 combiner
DVU0525 255 tf
DVU0936 255 tf
DVU0946
DVU2114
255 combiner
DVU2836
DVU0653
255 combiner
DVU3186
DVU0942
255 combiner
DVU3186
DVU2394
255 combiner
DVU3186
DVUA0100
255 combiner
DVU3193 255 tf

Warning: DVU0107 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
421 9.50e+02 CGccaAtgATGttgctttaAT
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RegPredict
422 3.40e+02 CA.a.cAgGgcAAGGcaGG
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RegPredict
485 2.90e+00 TTTTTTaCtgC
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RegPredict
486 3.50e+03 T.TCgtATtcATGCA
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU0107

DVU0107 is enriched for 7 functions in 3 categories.
Enrichment Table (7)
Function System
ABC-type amino acid transport/signal transduction systems, periplasmic component/domain cog/ cog
ionotropic glutamate receptor activity go/ molecular_function
extracellular-glutamate-gated ion channel activity go/ molecular_function
transport go/ biological_process
membrane go/ cellular_component
outer membrane-bounded periplasmic space go/ cellular_component
ABC transporters kegg/ kegg pathway
Module neighborhood information for DVU0107

DVU0107 has total of 39 gene neighbors in modules 221, 255
Gene neighbors (39)
Gene Common Name Description Module membership
DVU0105 glutamine ABC transporter ATP-binding protein 78, 255
DVU0107 glnH glutamine ABC transporter periplasmic glutamine-binding protein 221, 255
DVU0225 hypothetical protein DVU0225 215, 255
DVU0226 hypothetical protein DVU0226 50, 255
DVU0227 hypothetical protein DVU0227 63, 255
DVU0356 tag DNA-3-methyladenine glycosylase I 255, 308
DVU0357 hypothetical protein DVU0357 6, 255
DVU0500 selB selenocysteine-specific translation elongation factor 157, 255
DVU0501 hypothetical protein DVU0501 64, 221
DVU0547 high-affinity branched chain amino acid ABC transporter periplasmic branched chain amino acid-binding protein 255, 342
DVU0624 NapC/NirT cytochrome c family protein 153, 255
DVU0625 cytochrome c nitrite reductase, catalytic subunit NfrA 153, 255
DVU0642 alpha/beta fold family hydrolase 52, 221
DVU0702 cytochrome c family protein 215, 255
DVU1066 gpt xanthine-guanine phosphoribosyltransferase 221, 254
DVU1067 Bmp family membrane protein 146, 221
DVU1069 branched chain amino acid ABC transporter permease 221, 306
DVU1070 branched chain amino acid ABC transporter ATP-binding protein 221, 251
DVU1238 amino acid ABC transporter periplasmic amino acid-binding protein 146, 255
DVU1271 general secretion pathway protein F 174, 221
DVU1272 general secretion pathway protein E 65, 221
DVU1275 hypothetical protein DVU1275 65, 221
DVU1290 nitrate reductase subunit gamma 255, 344
DVU1323 secY preprotein translocase subunit SecY 221, 344
DVU1742 prevent-host-death family protein 221, 308
DVU2200 hypothetical protein DVU2200 171, 255
DVU2205 tryptophan-specific transport protein 255, 262
DVU2355 trmH tRNA (guanosine-2'-O-)-methyltransferase 221, 258
DVU2356 hypothetical protein DVU2356 154, 221
DVU2407 hypothetical protein DVU2407 216, 255
DVU2930 hypothetical protein DVU2930 206, 221
DVU3051 mutT mutator mutT protein 221, 291
DVU3052 ABC transporter ATP-binding protein 221, 270
DVU3055 ribonuclease 221, 251
DVU3103 tolB protein 186, 221
DVUA0006 magnesium transporter MgtE 163, 255
DVUA0072 glycosyl transferase, group 1 family protein 255, 304
DVUA0073 asparagine synthase (glutamine-hydrolyzing) 255, 337
DVUA0075 radical SAM domain-containing protein 255, 337
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU0107
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend