Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU2735 paaK-3

phenylacetate-coenzyme A ligase

CircVis
Functional Annotations (4)
Function System
Coenzyme F390 synthetase cog/ cog
metabolic process go/ biological_process
phenylacetate-CoA ligase activity go/ molecular_function
Phenylalanine metabolism kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU2735
(Mouseover regulator name to see its description)

DVU2735 is regulated by 29 influences and regulates 0 modules.
Regulators for DVU2735 paaK-3 (29)
Regulator Module Operator
DVU0110 62 tf
DVU0309
DVU1340
62 combiner
DVU0309
DVU1547
62 combiner
DVU0309
DVU3023
62 combiner
DVU1517 62 tf
DVU1561
DVU1584
62 combiner
DVU2547
DVU1730
62 combiner
DVU2567
DVU2675
62 combiner
DVU2960
DVU1730
62 combiner
DVU3080 62 tf
DVU3167 62 tf
DVUA0024 62 tf
DVU0030 236 tf
DVU0110
DVU0813
236 combiner
DVU0110
DVU1083
236 combiner
DVU0110
DVU1419
236 combiner
DVU0619 236 tf
DVU0653
DVU0813
236 combiner
DVU1584 236 tf
DVU1645
DVU2644
236 combiner
DVU1744 236 tf
DVU2423
DVU0653
236 combiner
DVU2423
DVU0936
236 combiner
DVU2644
DVU3066
236 combiner
DVU2836 236 tf
DVU3167 236 tf
DVU3167
DVU0309
236 combiner
DVU3167
DVU0813
236 combiner
DVU3193
DVU0813
236 combiner

Warning: DVU2735 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
121 1.70e-05 aattt.atGCcAGCCcTA.AGT
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RegPredict
122 3.60e+00 atAcaAaGATcAtTTTaT
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RegPredict
451 2.90e+02 AgTcaTc.CATTtTT
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RegPredict
452 7.90e+03 CatcActggaGgAA
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU2735

DVU2735 is enriched for 4 functions in 3 categories.
Enrichment Table (4)
Function System
Coenzyme F390 synthetase cog/ cog
metabolic process go/ biological_process
phenylacetate-CoA ligase activity go/ molecular_function
Phenylalanine metabolism kegg/ kegg pathway
Module neighborhood information for DVU2735

DVU2735 has total of 54 gene neighbors in modules 62, 236
Gene neighbors (54)
Gene Common Name Description Module membership
DVU0090 wcaG GDP-fucose synthetase 137, 236
DVU0247 response regulator 35, 62
DVU0250 hypothetical protein DVU0250 62, 280
DVU0274 hypothetical protein DVU0274 188, 236
DVU0290 lipoprotein 115, 236
DVU0319 NAD-dependent epimerase/dehydratase 62, 119
DVU0322 eno phosphopyruvate hydratase 229, 236
DVU0325 hypD hydrogenase expression/formation protein HypD 22, 62
DVU0349 NeuB family protein 62, 250
DVU0378 thioredoxin 137, 236
DVU0394 radical SAM domain-containing protein 62, 99
DVU0398 HMGL-like domain-containing protein 236, 292
DVU0418 lys1 saccharopine dehydrogenase 119, 236
DVU0499 hypothetical protein DVU0499 46, 62
DVU0523 flgM negative regulator of flagellin synthesis FlgM 62, 122
DVU0524 hypothetical protein DVU0524 62, 122
DVU0761 lipoprotein 35, 236
DVU0800 hypothetical protein DVU0800 62, 225
DVU0870 frr ribosome recycling factor 27, 236
DVU1072 hypothetical protein DVU1072 99, 236
DVU1368 rhodanese-like domain-containing protein 35, 236
DVU1412 glycerate dehydrogenase 236, 274
DVU1613 glutamate synthase subunit beta 192, 236
DVU1670 hypothetical protein DVU1670 53, 62
DVU1868 dapA dihydrodipicolinate synthase 62, 236
DVU1886 hypothetical protein DVU1886 128, 236
DVU1953 proA gamma-glutamyl phosphate reductase 46, 62
DVU1980 hypothetical protein DVU1980 115, 236
DVU2042 Fic family protein 62, 273
DVU2082 flagellin 62, 236
DVU2108 hypothetical protein DVU2108 66, 236
DVU2109 hypothetical protein DVU2109 236, 348
DVU2112 hypothetical protein DVU2112 27, 236
DVU2143 fba fructose-1,6-bisphosphate aldolase, class II 186, 236
DVU2203 L-PSP family endoribonuclease 62, 236
DVU2313 pgl 6-phosphogluconolactonase 115, 236
DVU2420 hypothetical protein DVU2420 119, 236
DVU2446 panB 3-methyl-2-oxobutanoate hydroxymethyltransferase 62, 115
DVU2460 hypothetical protein DVU2460 229, 236
DVU2475 ferredoxin-NADP(+) reductase subunit alpha 46, 62
DVU2490 histidinol phosphatase 35, 236
DVU2735 paaK-3 phenylacetate-coenzyme A ligase 62, 236
DVU2756 radical SAM domain-containing protein 62, 278
DVU2769 hypothetical protein DVU2769 27, 236
DVU2883 selA selenocysteine synthase 62, 162
DVU2884 aminopeptidase 1 62, 222
DVU2897 hypothetical protein DVU2897 62, 277
DVU2948 flagellin N-terminal domain-containing protein 62, 122
DVU3068 GAF domain/sensory box/EAL domain-containing protein 35, 62
DVU3208 membrane protein 62, 223
DVU3212 pyridine nucleotide-disulfide oxidoreductase 5, 236
DVU3351 queA S-adenosylmethionine:tRNA ribosyltransferase-isomerase 50, 236
DVU3352 lipoprotein 27, 236
DVU3364 hypothetical protein DVU3364 35, 62
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU2735
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend