methotrexate binding

id: GO:0051870
name: methotrexate binding
namespace: molecular_function
type: go
obsolete: False

Description: Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Parent Functions