phosphorylation of RNA polymerase II C-terminal domain

id: GO:0070816
name: phosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
type: go
obsolete: False

Description: The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.

Child Functions

idname
GO:0071619phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
GO:0071620phosphorylation of RNA polymerase II C-terminal domain serine 5 residues

Parent Functions

idname
GO:0006357regulation of transcription from RNA polymerase II promoter
GO:0006468protein phosphorylation