GO:0000165

MAPK cascade

Details: 
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267]
Evidence Code: 
ISO

PITA_231

Mega Cluster: 
2
Residual: 
0.14
Up.MEME Motif1 Matches: 
SP1_MA0079.2
Klf4_MA0039.2
SP1_MA0079.1
V$SP1_Q6_M00196
V$SP4_Q5_M01273
V$SP1_Q4_01_M00932
V$SP1_Q6_01_M00931
V$SP1_Q2_01_M00933
V$GC_01_M00255
V$SP1_03_M02281
V$ZFP281_01_M01597
V$SP1_02_M01303
V$MAZR_01_M00491
V$UF1H3BETA_Q6_M01068
V$GKLF_02_M01588
V$KLF7_03_M02773
V$SP2_01_M01783
V$SMAD4_04_M02898
V$E2F3_Q6_M02089
V$SP1_01_M00008
V$ZFP281_04_M02831
V$CKROX_Q2_M01175
V$SP4_03_M02810
V$ETF_Q6_M00695
V$SP1SP3_Q4_M01219
V$ZBP89_Q4_M01816
V$ZNF219_01_M01122
V$MAZ_Q6_01_M02023
V$BCL6B_04_M02844
V$KROX_Q6_M00982
V$CACBINDINGPROTEIN_Q6_M00720
V$ZFP410_04_M02936
V$MAZ_Q6_M00649
V$CACD_01_M01113
V$EGR1_Q6_M01873
V$KLF15_Q2_M01714
V$EGR1_06_M02744
V$ZFP740_03_M02834
V$FKLF_Q5_M01837
Klf7.1
Smad3.1
Sp4.1
Zfp281.2
Bcl6b.2
Zfp410.1
Egr1.1
Zfp740.1
Sp4.2
Ascl2.2
SP4_C2H2_full_monomeric_17_1
KLF16_C2H2_DBD_monomeric_11_1
SP1_C2H2_DBD_monomeric_11_1
SP3_C2H2_DBD_monomeric_11_1
KLF14_C2H2_DBD_monomeric_14_1
SP8_C2H2_DBD_monomeric_12_1
KLF13_C2H2_full_monomeric_18_1
Klf12_C2H2_DBD_monomeric_15_1
ZNF740_C2H2_full_monomeric_10_1
Up.WEEDER Motif1 Matches: 
NA