Organism : Methanococcus maripaludis S2 | Module List :
MMP0955 sucD

succinyl-CoA synthetase subunit alpha

CircVis
Functional Annotations (12)
Function System
Succinyl-CoA synthetase, alpha subunit cog/ cog
succinate-CoA ligase (ADP-forming) activity go/ molecular_function
metabolic process go/ biological_process
succinate-CoA ligase complex (ADP-forming) go/ cellular_component
Citrate cycle (TCA cycle) kegg/ kegg pathway
Propanoate metabolism kegg/ kegg pathway
C5-Branched dibasic acid metabolism kegg/ kegg pathway
Carbon fixation pathways in prokaryotes kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
sucCoAalpha tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for MMP0955
(Mouseover regulator name to see its description)

MMP0955 is regulated by 5 influences and regulates 0 modules.
Regulators for MMP0955 sucD (5)
Regulator Module Operator
MMP0033
H2
60 combiner
MMP0052 60 tf
MMP0907
MMP1646
60 combiner
MMP1015 60 tf
MMP1303
MMP1646
60 combiner

Warning: MMP0955 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
781 1.80e+03 cGaATTtaCgG
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782 2.90e+03 CTCGCACC
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893 1.40e+04 GCGAaGG
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894 1.40e+04 CGtCAGC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for MMP0955

MMP0955 is enriched for 12 functions in 3 categories.
Enrichment Table (12)
Function System
Succinyl-CoA synthetase, alpha subunit cog/ cog
succinate-CoA ligase (ADP-forming) activity go/ molecular_function
metabolic process go/ biological_process
succinate-CoA ligase complex (ADP-forming) go/ cellular_component
Citrate cycle (TCA cycle) kegg/ kegg pathway
Propanoate metabolism kegg/ kegg pathway
C5-Branched dibasic acid metabolism kegg/ kegg pathway
Carbon fixation pathways in prokaryotes kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
sucCoAalpha tigr/ tigrfam
Module neighborhood information for MMP0955

MMP0955 has total of 34 gene neighbors in modules 60, 120
Gene neighbors (34)
Gene Common Name Description Module membership
MMP0013 argH argininosuccinate lyase 52, 120
MMP0073 argG argininosuccinate synthase 27, 120
MMP0080 glutamate synthase large subunit 7, 60
MMP0081 gltB glutamate synthase large subunit 16, 60, 112
MMP0133 guaB inosine-5'-monophosphate dehydrogenase 25, 120, 140
MMP0223 hypothetical protein MMP0223 120, 130
MMP0224 hemL glutamate-1-semialdehyde aminotransferase 60, 130, 140
MMP0297 aIF-2_beta translation initiation factor IF-2 subunit beta 60, 81
MMP0340 pycB pyruvate carboxylase subunit B 24, 86, 120, 141, 149
MMP0341 pycA pyruvate carboxylase subunit A 67, 86, 120
MMP0417 hisA 1-(5-phosphoribosyl)-5- 60, 137
MMP0418 carbohydrate kinase PfkB 60, 137, 143
MMP0696 proS prolyl-tRNA synthetase 7, 60
MMP0880 aksF isopropylmalate/isohomocitrate dehydrogenase 24, 60, 140, 143
MMP0893 pyrG CTP synthetase 7, 60
MMP0894 guaA GMP synthase subunit B 60, 112
MMP0955 sucD succinyl-CoA synthetase subunit alpha 60, 120
MMP1017 lysC aspartate kinase 24, 60, 112
MMP1101 acetylornithine aminotransferase 27, 120
MMP1113 transketoloase, C terminal half 96, 120
MMP1114 rpe Pentose-5-phosphate 3-epimerase 109, 120
MMP1115 transketolase, N terminal half 109, 120
MMP1146 purF amidophosphoribosyltransferase 7, 60, 137, 143
MMP1188 hypothetical protein MMP1188 60, 112
MMP1189 ribose-5-phosphate isomerase A 60, 139
MMP1222 radA DNA repair and recombination protein RadA 86, 120
MMP1253 hypothetical protein MMP1253 52, 120
MMP1254 purM phosphoribosylaminoimidazole synthetase 96, 120
MMP1255 pheT phenylalanyl-tRNA synthetase subunit beta 60, 120
MMP1314 phosphoesterase domain-containing protein 52, 120
MMP1316 korB 2-oxoglutarate ferredoxin oxidoreductase subunit beta 7, 120, 137
MMP1480 aconitase family 60, 87, 92
MMP1532 pgk phosphoglycerate kinase 120, 137
MMP1640 S-adenosylmethionine synthetase 16, 60
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for MMP0955
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend