Organism : Methanococcus maripaludis S2 | Module List :
MMP1605

pyruvate kinase

CircVis
Functional Annotations (12)
Function System
Pyruvate kinase cog/ cog
magnesium ion binding go/ molecular_function
pyruvate kinase activity go/ molecular_function
glycolysis go/ biological_process
potassium ion binding go/ molecular_function
Glycolysis / Gluconeogenesis kegg/ kegg pathway
Purine metabolism kegg/ kegg pathway
Pyruvate metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
pyruv_kin tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for MMP1605
(Mouseover regulator name to see its description)

MMP1605 is regulated by 8 influences and regulates 0 modules.
Regulators for MMP1605 (8)
Regulator Module Operator
MMP0032
MMP0257
1 combiner
MMP0209 1 tf
MMP1447 1 tf
H2 54 ef
MMP0499
MMP1065
54 combiner
MMP0527 54 tf
MMP0907
MMP1646
54 combiner
MMP1015 54 tf

Warning: MMP1605 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 8 motifs predicted.

Motif Table (8)
Motif Id e-value Consensus Motif Logo
663 3.00e+01 CgacCC.c.agG
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664 7.60e+03 CcgcTg
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769 9.40e+00 gaAA.CtcCc
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770 5.80e+02 GGctTGcagA
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943 1.30e+00 CtCCCCct
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944 1.90e+04 GGtAcgagCTTT.Ac.aG
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979 1.70e-05 ggGGGagtt
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980 2.00e+00 ctctTctCa.ATa.ccccGTA
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for MMP1605

MMP1605 is enriched for 12 functions in 3 categories.
Enrichment Table (12)
Function System
Pyruvate kinase cog/ cog
magnesium ion binding go/ molecular_function
pyruvate kinase activity go/ molecular_function
glycolysis go/ biological_process
potassium ion binding go/ molecular_function
Glycolysis / Gluconeogenesis kegg/ kegg pathway
Purine metabolism kegg/ kegg pathway
Pyruvate metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
pyruv_kin tigr/ tigrfam
Module neighborhood information for MMP1605

MMP1605 has total of 88 gene neighbors in modules 1, 54, 146, 166
Gene neighbors (88)
Gene Common Name Description Module membership
Antisense_2 None 1, 22
Antisense_23 None 1, 117
Antisense_5 None 1, 22
MMP0018 LysR family transcriptional regulator 85, 166
MMP0027 TrkA-N domain-containing protein 54, 57
MMP0070 tungsten containing formylmethanofruran dehydrogenase subunit C-like protein 54, 65
MMP0097 transcriptional regulator 58, 166
MMP0119 birA biotin--acetyl-CoA-carboxylase ligase 1, 75, 142
MMP0122 hypothetical protein MMP0122 57, 102, 146
MMP0128 cyclase family protein 73, 146, 153
MMP0153 aksA trans-homoaconitate synthase 1, 143
MMP0154 hypothetical protein MMP0154 1, 13
MMP0166 MATE family drug/sodium antiporter 1, 28
MMP0167 ABC transporter ATP-binding protein 1, 28
MMP0168 ParR family transcriptional regulator 1, 28
MMP0176 cell division protein CDC48 1, 46
MMP0180 ribC riboflavin synthase 1, 58
MMP0215 hypothetical protein MMP0215 54, 156
MMP0238 hypothetical protein MMP0238 160, 166
MMP0239 hypothetical protein MMP0239 1, 49, 75, 106
MMP0447 nitrogenase-like protein 4, 146
MMP0450 ferredoxin 1, 70
MMP0451 hypothetical protein MMP0451 1, 70
MMP0455 amino-acid ABC transporter 54, 146
MMP0482 hypothetical protein MMP0482 54, 55
MMP0483 hypothetical protein MMP0483 54, 55
MMP0499 hypothetical protein MMP0499 22, 28, 144, 146, 153
MMP0514 modA molybdenum ABC transporter periplasmic molybdate-binding protein 99, 146
MMP0520 HAD superfamily ATPase 73, 146
MMP0522 hypothetical protein MMP0522 42, 85, 146, 153
MMP0523 ABC transporter ATP-binding protein 42, 85, 146, 153
MMP0524 hypothetical protein MMP0524 4, 58, 146, 153, 163
MMP0525 hypothetical protein MMP0525 4, 146, 163
MMP0536 hypothetical protein MMP0536 1, 28
MMP0538 hypothetical protein MMP0538 85, 166
MMP0547 RecJ-like protein 22, 166
MMP0558 hypothetical protein MMP0558 50, 166
MMP0608 2-hydroxyglutaryl-CoA dehydratase subunit A-like protein 1, 28
MMP0612 LigT 2'-5' RNA ligase 54, 57
MMP0621 xylose isomerase domain-containing protein 54, 57
MMP0638 hypothetical protein MMP0638 54, 55
MMP0648 rtcA RNA 3'-terminal-phosphate cyclase 67, 146
MMP0652 hypothetical protein MMP0652 131, 166
MMP0672 binding-protein dependent transport system inner membrane protein 37, 54
MMP0685 N-6 adenine-specific DNA methylase 1, 144
MMP0693 aminoacyl-tRNA synthetase, class II 33, 54
MMP0756 hypothetical protein MMP0756 42, 166
MMP0757 hypothetical protein MMP0757 58, 146
MMP0758 HNH endonuclease:HNH nuclease 45, 166
MMP0759 hypothetical protein MMP0759 45, 166
MMP0775 hypothetical protein MMP0775 42, 146, 153, 163
MMP0785 dop chymotrypsin serine protease 2, 146, 159
MMP0813 hypothetical protein MMP0813 146, 166
MMP0835 hypothetical protein MMP0835 85, 146
MMP0842 hypothetical protein MMP0842 69, 166
MMP0863 CBS domain-containing protein 2, 54, 146
MMP0864 napA-2 Na+/H+ exchanger 50, 146, 166
MMP0871 hypothetical protein MMP0871 22, 153, 166
MMP0876 cofG FO synthase subunit 1 1, 129
MMP0903 hypothetical protein MMP0903 33, 54, 55
MMP1071 hypothetical protein MMP1071 1, 106
MMP1072 aminotransferase (subgroup I) aromatic aminotransferase 1, 106
MMP1110 hypothetical protein MMP1110 31, 146
MMP1124 thiamine-monophosphate kinase 102, 146
MMP1140 fdxA ferredoxin 1, 46
MMP1185 hydrogen uptake protein:hydrogenase maturation protease HycI 1, 46
MMP1234 UBA/THIF-type NAD/FAD binding protein 33, 54, 55, 106
MMP1238 bioB biotin synthase 1, 153
MMP1240 Sep-tRNA:Cys-tRNA synthetase 1, 55
MMP1241 hypothetical protein MMP1241 1, 55, 94, 117
MMP1243 UBA/THIF-type NAD/FAD binding protein 89, 146
MMP1268 hypothetical protein MMP1268 85, 166
MMP1291 glycoside hydrolase family protein 43, 166
MMP1292 glycoside hydrolase 15-like protein 43, 166
MMP1294 glgA starch synthase 43, 150, 166
MMP1296 pfkC ADP-specific phosphofructokinase 45, 166
MMP1549 AP endonuclease 1, 94, 152
MMP1550 NADP oxidoreductase, coenzyme F420-dependent 1, 58
MMP1552 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 54, 150
MMP1604 hypothetical protein MMP1604 43, 166
MMP1605 pyruvate kinase 1, 54, 146, 166
MMP1606 flavoprotein:DNA/pantothenate metabolism flavoprotein 1, 13, 49
MMP1641 soluble P-type ATPase 54, 57
MMP1653 hypothetical protein MMP1653 150, 166
MMP1654 hypothetical protein MMP1654 50, 166
MMP1664 hypothetical protein MMP1664 42, 146
Mma-sR04 None 100, 146
Unanno_10 None 64, 146
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for MMP1605
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend