Module 460 Residual: 0.59

Title Bicluster Model Residual Score
bicluster_0460 v02 0.59 -12.23
Displaying 1 - 17 of 17
Rv0615 Possible membrane protein

Details for Rv0615 - Possible membrane protein

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.71 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0615

Tuberculist Genomic Region

Rv2553c FIG004453: protein YceG like

Details for Rv2553c - FIG004453: protein YceG like

GO Terms: GO:0005618

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: 0.28

Go to Gene Page: Rv2553c

Tuberculist Genomic Region

Rv1005c Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)

Details for Rv1005c - Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)

GO Terms: GO:0046820, GO:0005886, GO:0040007

PATRIC Pathways: Folate biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.08 | In vivo Essential: NA

Go to Gene Page: Rv1005c

Tuberculist Genomic Region

Rv1539 Lipoprotein signal peptidase (EC 3.4.23.36)

Details for Rv1539 - Lipoprotein signal peptidase (EC 3.4.23.36)

GO Terms: GO:0006497, GO:0009405, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.04 | In vitro Essential: 0.13 | In vivo Essential: NA

Go to Gene Page: Rv1539

Tuberculist Genomic Region

Rv1540 Ribosomal large subunit pseudouridine synthase D (EC 4.2.1.70)

Details for Rv1540 - Ribosomal large subunit pseudouridine synthase D (EC 4.2.1.70)

GO Terms: NA

PATRIC Pathways: Pyrimidine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1540

Tuberculist Genomic Region

Rv1599 Histidinol dehydrogenase (EC 1.1.1.23)

Details for Rv1599 - Histidinol dehydrogenase (EC 1.1.1.23)

GO Terms: GO:0004399, GO:0040007

PATRIC Pathways: Histidine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv1599

Tuberculist Genomic Region

Rv1600 Histidinol-phosphate aminotransferase (EC 2.6.1.9)

Details for Rv1600 - Histidinol-phosphate aminotransferase (EC 2.6.1.9)

GO Terms: GO:0004400, GO:0005618, GO:0005886, GO:0040007

PATRIC Pathways: Novobiocin biosynthesis, Tyrosine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Tropane, piperidine and pyridine alkaloid biosynthesis, Phenylalanine metabolism, Histidine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv1600

Tuberculist Genomic Region

Rv1601 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)

Details for Rv1601 - Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)

GO Terms: GO:0004424, GO:0040007

PATRIC Pathways: Histidine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.02 | In vivo Essential: NA

Go to Gene Page: Rv1601

Tuberculist Genomic Region

Rv1602 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)

Details for Rv1602 - Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)

GO Terms: GO:0003824, GO:0040007

PATRIC Pathways: Purine metabolism, Butirosin and neomycin biosynthesis

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.03 | In vivo Essential: NA

Go to Gene Page: Rv1602

Tuberculist Genomic Region

Rv2540c Chorismate synthase (EC 4.2.3.5)

Details for Rv2540c - Chorismate synthase (EC 4.2.3.5)

GO Terms: GO:0004107, GO:0004107, GO:0010181, GO:0016651, GO:0040007, GO:0051287

PATRIC Pathways: Phenylalanine, tyrosine and tryptophan biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv2540c

Tuberculist Genomic Region

Rv2555c Alanyl-tRNA synthetase (EC 6.1.1.7)

Details for Rv2555c - Alanyl-tRNA synthetase (EC 6.1.1.7)

GO Terms: GO:0004813, GO:0005829, GO:0005886, GO:0040007

PATRIC Pathways: Aminoacyl-tRNA biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.10 | In vivo Essential: NA

Go to Gene Page: Rv2555c

Tuberculist Genomic Region

Rv3411c Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)

Details for Rv3411c - Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)

GO Terms: GO:0003938, GO:0005886, GO:0040007

PATRIC Pathways: Drug metabolism - other enzymes, Purine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.08 | In vivo Essential: NA

Go to Gene Page: Rv3411c

Tuberculist Genomic Region

Rv3419c YgjD/Kae1/Qri7 family, required for threonylcarbamoyladenosine (t(6)A) formation in tRNA

Details for Rv3419c - YgjD/Kae1/Qri7 family, required for threonylcarbamoyladenosine (t(6)A) formation in tRNA

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.53 | In vitro Essential: NA | In vivo Essential: 0.25

Go to Gene Page: Rv3419c

Tuberculist Genomic Region

Rv3420c Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-)
Rv3421c Inactive homolog of metal-dependent proteases, putative molecular chaperone

Details for Rv3421c - Inactive homolog of metal-dependent proteases, putative molecular chaperone

GO Terms: GO:0008450, GO:0006508

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.53 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3421c

Tuberculist Genomic Region

Rv3422c ATPase YjeE, predicted to have essential role in cell wall biosynthesis

Details for Rv3422c - ATPase YjeE, predicted to have essential role in cell wall biosynthesis

GO Terms: GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.17 | In vitro Essential: 0.17 | In vivo Essential: NA

Go to Gene Page: Rv3422c

Tuberculist Genomic Region

Rv3423c Alanine racemase (EC 5.1.1.1)

Details for Rv3423c - Alanine racemase (EC 5.1.1.1)

GO Terms: GO:0008784, GO:0008784, GO:0040007

PATRIC Pathways: D-Alanine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.08 | In vivo Essential: NA

Go to Gene Page: Rv3423c

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 55 e-value: 160
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0009081 | GO:0006412 | GO:0003984 | GO:0043225 | GO:0003735 branched-chain amino acid metabolic proc... | translation | acetolactate synthase activity | anion transmembrane-transporting ATPase ... | structural constituent of ribosome
Displaying 1 - 22 of 22
GO:0005618 |

cell wall

GO:0046820 |

4-amino-4-deoxychorismate synthase activity

GO:0005886 |

plasma membrane

GO:0040007 |

growth

GO:0006497 |

protein lipidation

GO:0009405 |

pathogenesis

GO:0004399 |

histidinol dehydrogenase activity

GO:0004400 |

histidinol-phosphate transaminase activity

GO:0004424 |

imidazoleglycerol-phosphate dehydratase activity

GO:0003824 |

catalytic activity

GO:0004107 |

chorismate synthase activity

GO:0010181 |

FMN binding

GO:0016651 |

oxidoreductase activity, acting on NADH or NADPH

GO:0051287 |

NAD binding

GO:0004813 |

alanine-tRNA ligase activity

GO:0005829 |

cytosol

GO:0003938 |

IMP dehydrogenase activity

GO:0008080 |

N-acetyltransferase activity

GO:0008450 |

O-sialoglycoprotein endopeptidase activity

GO:0006508 |

proteolysis

GO:0008784 |

alanine racemase activity