TFOE Searchable Data File

To investigate the MTB transcriptional landscape in a systematic manner, we developed a high-throughput approach to identify the genes controlled by nearly all predicted MTB TFs. We individually cloned and conditionally overexpressed 206 MTB TFs to induce the regulatory signature of each one. Using this approach we identified the sets of genes affected by TF overexpression (TFOE) and assembled them into an easily searchable map of transcriptional regulation in MTB.

Accessing large datasets like the TFOE expression data can be difficult when the data spreads over thousands of genes and hundreds of regulators. To address the difficulties usually associated with accessing large data sets, we have designed a simple Excel spreadsheet for querying TFOE data to find regulators of specific genes or sets of genes. (Rustad et al. Genome Biol. 2014)

Last update: 29/02/2015

TFOE Expression Data Records

Title Gene BioProject GEO Series Platform Accession Sample Method Sample Type References Release Date Repository
TFOE_4853_0302_C
TetR/ACRR family transcriptional regulator
PRJNA254351 GSE59086 GPL14824 GSM1426449 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_6324_0302
TetR/ACRR family transcriptional regulator
PRJNA254351 GSE59086 GPL14824 GSM1426450 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_2830_0042c
Transcriptional regulator, MarR family
PRJNA254351 GSE59086 GPL14824 GSM1426382 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_2455_0042c_C
Transcriptional regulator, MarR family
PRJNA254351 GSE59086 GPL14824 GSM1426381 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_8850_0038 PRJNA254351 GSE59086 GPL14824 GSM1426380 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_8173_0038_2 PRJNA254351 GSE59086 GPL14824 GSM1426379 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_8864_0042c_B
Transcriptional regulator, MarR family
PRJNA254351 GSE59086 GPL14824 GSM1426383 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_3297_0043c
Transcriptional regulator, GntR family
PRJNA254351 GSE59086 GPL14824 GSM1426384 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_5695_0043c
Transcriptional regulator, GntR family
PRJNA254351 GSE59086 GPL14824 GSM1426385 Tiling Array RNA 25232098 4-Jul-14 GEO
TFOE_9257_0043c
Transcriptional regulator, GntR family
PRJNA254351 GSE59086 GPL14824 GSM1426386 Tiling Array RNA 25232098 4-Jul-14 GEO