Rv1002c CONSERVED MEMBRANE PROTEIN

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv1002c CONSERVED MEMBRANE PROTEIN CDS 1118428 1119939 - 1 512 503 FALSE

Rv1002c (CONSERVED MEMBRANE PROTEIN) is predicted to be co-regulated in modules bicluster_0048 with residual 0.53 and bicluster_0189 with residual 0.44.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 3.40 and 37.00 for bicluster_0048 and 13,000.00 and 13,000.00 for bicluster_0189 respectively.

These modules are enriched for following go terms: glycerol metabolic process, alditol metabolic process, polyol metabolic process, alcohol metabolic process, organic hydroxy compound metabolic proce..., aspartic-type endopeptidase activity, aspartic-type peptidase activity, ATP-dependent DNA helicase activity, DNA-dependent ATPase activity.

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Uncharacterized protein Rv1002c_MT1031
Operon # Operon
670
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608142 NP_215518.1 Run
GO:0035269

protein O-linked mannosylation

protein O-linked mannosylation

Details: 
The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.
GO Category: 
biological_process
1
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: