Rv2667 ATP-dependent protease ATP-binding subunit ClpC2

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2667 clpC2 ATP-dependent protease ATP-binding subunit ClpC2 CDS 2983896 2984654 + 759 252 FALSE

Rv2667 (ATP-dependent protease ATP-binding subunit ClpC2) is predicted to be co-regulated in modules bicluster_0346 with residual 0.51 and bicluster_0394 with residual 0.56.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.14 for bicluster_0346 and 26.00 and 340.00 for bicluster_0394 respectively.

These modules are enriched for following go terms: cellular protein metabolic process, macromolecular complex, cytoplasmic part.

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Uncharacterized protein Rv2667_MT2741 ATP-dependent protease ATP-binding subunit ClpC2
Operon # Operon
1749 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
57117011 YP_177897.1 Run



The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.830000 1.27

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: