Rv3849 ESX-1 secreted protein regulator EspR

Rv3849 (ESX-1 secreted protein regulator EspR) is predicted to be co-regulated in modules bicluster_0033 with residual 0.56 and bicluster_0349 with residual 0.51.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0033 and 2.40 and 4,600.00 for bicluster_0349 respectively.

These modules are enriched for following go terms: lipopolysaccharide metabolic process, lipopolysaccharide biosynthetic process, carbon-carbon lyase activity, oxo-acid-lyase activity.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 31 - 40 of 46
Gene Target Differential Expression Distance Expression pvalue Type
Repressed -97 -1.15 0.00421357 Internal.TSS
PROBABLE PROLINE AND GLYCINE RICH TRANSMEMBRANE PROTEIN
Repressed -15 -1.78 0.00000886 Primary.TSS
No -96 0.01 0.991552 Primary.TSS
Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8)
Repressed 20 -0.73 0.000000000202 Primary.TSS
Daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC
No 63 -0.15 0.669659 CDS
PGL/p-HBAD biosynthesis glycosyltransferase
Repressed 26 -1.44 0.00000208 CDS
PE family protein
Repressed -85 -1.22 0.00229873 CDS
PPE family protein
Repressed -32 -0.71 0.00000527 Primary.TSS
Multidrug resistance protein B
No -37 0.2 0.215755 Internal.TSS
Sporulation regulatory protein WhiD
No -108 0.06 0.839832 Primary.TSS
not assigned to any KEGG Pathway.
GO:0003677

DNA binding

DNA binding

Details: 
Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).
GO Category: 
molecular_function
37
Total items in this category:  
GO:0005576

extracellular region

extracellular region

Details: 
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO Category: 
cellular_component
272
Total items in this category:  
GO:0005618

cell wall

cell wall

Details: 
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan.
GO Category: 
cellular_component
320
Total items in this category:  
GO:0005829

cytosol

cytosol

Details: 
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO Category: 
cellular_component
371
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0006355

regulation of transcription, DNA-dependent

regulation of transcription, DNA-dependent

Details: 
Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription.
GO Category: 
biological_process
15
Total items in this category:  
GO:0050708

regulation of protein secretion

regulation of protein secretion

Details: 
Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell or group of cells.
GO Category: 
biological_process
1
Total items in this category:  
GO:0052572

response to host immune response

response to host immune response

Details: 
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO Category: 
biological_process
62
Total items in this category:  
No TFOE experiment results were found

TRIP log2 fold abundance change

NA
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 13.23 U
D3I 3 3 3.83 13.51 I
D3U 3 3 3.83 13.04 U
D5I 9 5 6.00 11.14 I
D5U 17 5 6.00 13.45 U
D7I 18 7 8.14 9.66 I
D7U 19 7 8.14 13.18 U
D14I 4 14 15.63 5.61 I
D14U 4 14 15.63 11.74 U
D17I 3 17 19.15 I
D17U 3 17 19.15 11.46 U
D21I 4 21 23.23 6.02 I
D21U 4 21 23.23 11.59 U
D24I 3 24 26.60 I
D24U 3 24 26.60 11.34 U
D28I 4 28 30.61 3.90 I
D28U 4 28 30.61 11.36 U