Organism : Pseudomonas aeruginosa | Module List :
PA1157

probable two-component response regulator (NCBI)

CircVis
Functional Annotations (6)
Function System
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain cog/ cog
two-component response regulator activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
DNA binding go/ molecular_function
regulation of transcription, DNA-dependent go/ biological_process
Two-component system kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for PA1157
(Mouseover regulator name to see its description)

PA1157 is regulated by 45 influences and regulates 0 modules.
Regulators for PA1157 (45)
Regulator Module Operator
PA0125 528 tf
PA0763 528 tf
PA0815 528 tf
PA1142 528 tf
PA1184 528 tf
PA1241 528 tf
PA1422 528 tf
PA1484 528 tf
PA1490 528 tf
PA2032 528 tf
PA2622 528 tf
PA2957 528 tf
PA3215 528 tf
PA3604 528 tf
PA3778 528 tf
PA3804 528 tf
PA3948 528 tf
PA5342 528 tf
PA5550 528 tf
PA5562 528 tf
PA0120 501 tf
PA0207 501 tf
PA0236 501 tf
PA0831 501 tf
PA0905 501 tf
PA1128 501 tf
PA1142 501 tf
PA1422 501 tf
PA1627 501 tf
PA2032 501 tf
PA2047 501 tf
PA2115 501 tf
PA2258 501 tf
PA2718 501 tf
PA3921 501 tf
PA4021 501 tf
PA4157 501 tf
PA4279 501 tf
PA4354 501 tf
PA4769 501 tf
PA4853 501 tf
PA4890 501 tf
PA5059 501 tf
PA5437 501 tf
PA5483 501 tf

Warning: PA1157 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3816 8.40e+01 TTTTTcaT
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3817 1.90e+02 GtatttccaggAA.G
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3870 8.80e+04 TAaaGTaAAAA
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3871 1.30e+03 ttAtaATGCgcgCcGctct
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for PA1157

PA1157 is enriched for 6 functions in 3 categories.
Module neighborhood information for PA1157

PA1157 has total of 38 gene neighbors in modules 501, 528
Gene neighbors (38)
Gene Common Name Description Module membership
PA0006 PA0006 hypothetical protein (NCBI) 384, 528
PA0040 PA0040 hypothetical protein (NCBI) 265, 501
PA0285 PA0285 hypothetical protein (NCBI) 517, 528
PA0541 PA0541 hypothetical protein (NCBI) 170, 528
PA0706 cat chloramphenicol acetyltransferase (NCBI) 384, 501
PA1142 PA1142 probable transcriptional regulator (NCBI) 306, 528
PA1157 PA1157 probable two-component response regulator (NCBI) 501, 528
PA1158 PA1158 probable two-component sensor (NCBI) 175, 528
PA1164 PA1164 hypothetical protein (NCBI) 139, 528
PA1788 PA1788 hypothetical protein (NCBI) 181, 528
PA1791 PA1791 hypothetical protein (NCBI) 265, 501
PA1839 PA1839 hypothetical protein (NCBI) 299, 501
PA2660 PA2660 hypothetical protein (NCBI) 478, 501
PA2806 PA2806 hypothetical protein (NCBI) 372, 528
PA3179 PA3179 hypothetical protein (NCBI) 404, 528
PA3215 PA3215 probable transcriptional regulator (NCBI) 268, 528
PA3539 PA3539 hypothetical protein (NCBI) 517, 528
PA3638 PA3638 hypothetical protein (NCBI) 315, 528
PA3677 PA3677 probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor (NCBI) 528, 550
PA3717 PA3717 probable peptidyl-prolyl cis-trans isomerase, FkbP-type (NCBI) 181, 528
PA3741 PA3741 hypothetical protein (NCBI) 404, 501
PA3777 xseA exodeoxyribonuclease VII large subunit (NCBI) 62, 528
PA3778 PA3778 probable transcriptional regulator (NCBI) 62, 528
PA3850 PA3850 hypothetical protein (NCBI) 265, 501
PA3984 lnt apolipoprotein N-acyltransferase (NCBI) 517, 528
PA4119 aph aminoglycoside 3'-phosphotransferase type IIb (NCBI) 65, 501
PA4543 PA4543 hypothetical protein (NCBI) 268, 528
PA4583 PA4583 hypothetical protein (NCBI) 61, 501
PA4585 rtcA RNA 3'-terminal-phosphate cyclase (NCBI) 61, 501
PA4724 PA4724 glutamyl-tRNA synthetase (NCBI) 286, 501
PA4800 PA4800 hypothetical protein (NCBI) 61, 501
PA4928 PA4928 hypothetical protein (NCBI) 207, 501
PA4952 PA4952 ribosome-associated GTPase (NCBI) 306, 501
PA5038 aroB 3-dehydroquinate synthase (NCBI) 78, 528
PA5048 PA5048 probable nuclease (NCBI) 135, 501
PA5120 PA5120 hypothetical protein (NCBI) 48, 501
PA5127 PA5127 probable rRNA methylase (NCBI) 181, 528
PA5567 PA5567 tRNA modification GTPase (NCBI) 60, 528
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for PA1157
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend