Organism : Pseudomonas aeruginosa | Module List :
PA4358

probable ferrous iron transport protein (NCBI)

CircVis
Functional Annotations (9)
Function System
Fe2+ transport system protein B cog/ cog
nucleoside binding go/ molecular_function
GTP binding go/ molecular_function
intracellular go/ cellular_component
Gram-negative-bacterium-type cell wall go/ cellular_component
ferrous iron transmembrane transporter activity go/ molecular_function
ferrous iron transport go/ biological_process
integral to membrane go/ cellular_component
feoB tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for PA4358
(Mouseover regulator name to see its description)

PA4358 is regulated by 55 influences and regulates 0 modules.
Regulators for PA4358 (55)
Regulator Module Operator
PA0448 162 tf
PA0515 162 tf
PA0527 162 tf
PA1050 162 tf
PA1196 162 tf
PA2126 162 tf
PA2622 162 tf
PA3458 162 tf
PA3879 162 tf
PA3973 162 tf
PA4853 162 tf
PA5550 162 tf
PA0120 553 tf
PA0133 553 tf
PA0155 553 tf
PA0207 553 tf
PA0225 553 tf
PA0236 553 tf
PA0268 553 tf
PA0367 553 tf
PA0547 553 tf
PA0601 553 tf
PA0764 553 tf
PA1015 553 tf
PA1229 553 tf
PA1309 553 tf
PA1520 553 tf
PA1544 553 tf
PA1630 553 tf
PA1633 553 tf
PA1864 553 tf
PA1998 553 tf
PA2028 553 tf
PA2115 553 tf
PA2423 553 tf
PA2510 553 tf
PA2588 553 tf
PA2692 553 tf
PA2713 553 tf
PA2849 553 tf
PA3563 553 tf
PA3714 553 tf
PA3757 553 tf
PA3932 553 tf
PA3973 553 tf
PA3995 553 tf
PA4070 553 tf
PA4109 553 tf
PA4132 553 tf
PA4157 553 tf
PA4436 553 tf
PA4462 553 tf
PA4659 553 tf
PA4778 553 tf
PA5437 553 tf

Warning: PA4358 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3152 2.90e-10 tTGAtcCaggtCAa
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3153 2.70e-01 TTaa..aAg.aTTaa
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3918 1.10e-05 cgtccTTAAGcga.cctTAA
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3919 4.50e+03 ATaTAAA
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for PA4358

PA4358 is enriched for 9 functions in 3 categories.
Enrichment Table (9)
Function System
Fe2+ transport system protein B cog/ cog
nucleoside binding go/ molecular_function
GTP binding go/ molecular_function
intracellular go/ cellular_component
Gram-negative-bacterium-type cell wall go/ cellular_component
ferrous iron transmembrane transporter activity go/ molecular_function
ferrous iron transport go/ biological_process
integral to membrane go/ cellular_component
feoB tigr/ tigrfam
Module neighborhood information for PA4358

PA4358 has total of 39 gene neighbors in modules 162, 553
Gene neighbors (39)
Gene Common Name Description Module membership
PA0200 PA0200 hypothetical protein (NCBI) 162, 429
PA0527 dnr transcriptional regulator Dnr (NCBI) 162, 225
PA0545 PA0545 hypothetical protein (NCBI) 162, 375
PA1049 pdxH pyridoxamine 5'-phosphate oxidase (NCBI) 162, 225
PA1050 PA1050 hypothetical protein (NCBI) 162, 253
PA1076 PA1076 hypothetical protein (NCBI) 162, 416
PA1196 PA1196 probable transcriptional regulator (NCBI) 68, 162
PA1197 PA1197 NAD-dependent deacetylase (NCBI) 68, 162
PA1414 PA1414 hypothetical protein (NCBI) 162, 416
PA1429 PA1429 probable cation-transporting P-type ATPase (NCBI) 21, 162
PA1559 PA1559 hypothetical protein (NCBI) 5, 553
PA1560 PA1560 hypothetical protein (NCBI) 5, 553
PA2126 PA2126 hypothetical protein (NCBI) 162, 321
PA2127 PA2127 hypothetical protein (NCBI) 162, 225
PA3054 PA3054 hypothetical protein (NCBI) 162, 225
PA3458 PA3458 probable transcriptional regulator (NCBI) 38, 162
PA3552 PA3552 hypothetical protein (NCBI) 5, 553
PA3553 PA3553 probable glycosyl transferase (NCBI) 5, 553
PA3554 PA3554 hypothetical protein (NCBI) 5, 553
PA3555 PA3555 hypothetical protein (NCBI) 5, 553
PA3556 arnT inner membrane L-Ara4N transferase ArnT (NCBI) 5, 553
PA3557 PA3557 hypothetical protein (NCBI) 5, 553
PA3558 PA3558 hypothetical protein (NCBI) 5, 553
PA3559 PA3559 probable nucleotide sugar dehydrogenase (NCBI) 5, 553
PA3572 PA3572 hypothetical protein (NCBI) 162, 416
PA3839 PA3839 probable sodium:sulfate symporter (NCBI) 162, 225
PA3878 narX two-component sensor NarX (NCBI) 162, 225
PA3879 narL two-component response regulator NarL (NCBI) 38, 162
PA4235 bfrA bacterioferritin (NCBI) 162, 225
PA4357 PA4357 hypothetical protein (NCBI) 162, 553
PA4358 PA4358 probable ferrous iron transport protein (NCBI) 162, 553
PA4359 PA4359 hypothetical protein (NCBI) 162, 553
PA4610 PA4610 hypothetical protein (NCBI) 38, 162
PA4773 PA4773 hypothetical protein (NCBI) 5, 553
PA4774 PA4774 hypothetical protein (NCBI) 5, 553
PA4775 PA4775 hypothetical protein (NCBI) 5, 553
PA4776 pmrA PmrA: two-component regulator system response regulator PmrA (NCBI) 5, 553
PA4777 pmrB PmrB: two-component regulator system signal sensor kinase PmrB (NCBI) 5, 553
PA4782 PA4782 hypothetical protein (NCBI) 5, 553
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for PA4358
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend