Organism : Pseudomonas aeruginosa | Module List :
PA5252

probable ATP-binding component of ABC transporter (NCBI)

CircVis
Functional Annotations (3)
Function System
ATPase components of ABC transporters with duplicated ATPase domains cog/ cog
ATP binding go/ molecular_function
ATPase activity go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for PA5252
(Mouseover regulator name to see its description)

PA5252 is regulated by 36 influences and regulates 0 modules.
Regulators for PA5252 (36)
Regulator Module Operator
PA0236 490 tf
PA0456 490 tf
PA1754 490 tf
PA1853 490 tf
PA2047 490 tf
PA2093 490 tf
PA2447 490 tf
PA2497 490 tf
PA2921 490 tf
PA2957 490 tf
PA3007 490 tf
PA3322 490 tf
PA4275 490 tf
PA4451 490 tf
PA4745 490 tf
PA4764 490 tf
PA4769 490 tf
PA4853 490 tf
PA5125 490 tf
PA5344 490 tf
PA5438 490 tf
PA5483 490 tf
PA1128 151 tf
PA1422 151 tf
PA1504 151 tf
PA1653 151 tf
PA2028 151 tf
PA2921 151 tf
PA3322 151 tf
PA3583 151 tf
PA3864 151 tf
PA4196 151 tf
PA4745 151 tf
PA4890 151 tf
PA5261 151 tf
PA5403 151 tf

Warning: PA5252 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3132 1.40e-09 atgcgtCAaA..gcTtgaccgAaa
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3133 1.90e-05 AG.gTa.a.At..CtGA.CTGA.a
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3794 1.30e+02 tTttCgaGacAatcCcat
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3795 2.20e+01 tCGcCcTtcTaGagt
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for PA5252

PA5252 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
ATPase components of ABC transporters with duplicated ATPase domains cog/ cog
ATP binding go/ molecular_function
ATPase activity go/ molecular_function
Module neighborhood information for PA5252

PA5252 has total of 40 gene neighbors in modules 151, 490
Gene neighbors (40)
Gene Common Name Description Module membership
PA0308 PA0308 hypothetical protein (NCBI) 220, 490
PA0760 PA0760 hypothetical protein (NCBI) 135, 490
PA0772 recO DNA repair protein RecO (NCBI) 151, 387
PA0789 PA0789 probable amino acid permease (NCBI) 100, 490
PA1126 PA1126 hypothetical protein (NCBI) 265, 490
PA1375 pdxB erythronate-4-phosphate dehydrogenase (NCBI) 351, 490
PA1416 PA1416 hypothetical protein (NCBI) 151, 240
PA1417 PA1417 probable decarboxylase (NCBI) 151, 240
PA1418 PA1418 probable sodium:solute symport protein (NCBI) 151, 240
PA1419 PA1419 probable transporter (NCBI) 151, 240
PA1420 PA1420 hypothetical protein (NCBI) 151, 240
PA1421 gbuA guanidinobutyrase (NCBI) 151, 240
PA1422 gbuR GbuR (NCBI) 151, 517
PA1653 PA1653 probable transcriptional regulator (NCBI) 151, 550
PA1654 PA1654 probable aminotransferase (NCBI) 151, 462
PA1655 PA1655 probable glutathione S-transferase (NCBI) 151, 462
PA1853 PA1853 probable transcriptional regulator (NCBI) 117, 490
PA2503 PA2503 hypothetical protein (NCBI) 351, 490
PA2560 PA2560 hypothetical protein (NCBI) 151, 248
PA2561 PA2561 probable chemotaxis transducer (NCBI) 48, 151
PA2843 PA2843 probable aldolase (NCBI) 151, 374
PA2942 PA2942 probable magnesium chelatase (NCBI) 58, 490
PA2982 PA2982 hypothetical protein (NCBI) 387, 490
PA2983 PA2983 probable tolQ-type transport protein (NCBI) 143, 490
PA3208 PA3208 hypothetical protein (NCBI) 8, 490
PA3397 fpr ferredoxin--NADP+ reductase (NCBI) 371, 490
PA3537 argF ornithine carbamoyltransferase, anabolic (NCBI) 276, 490
PA3794 PA3794 hypothetical protein (NCBI) 139, 490
PA3862 PA3862 hypothetical protein (NCBI) 151, 517
PA3887 nhaP Na+/H+ antiporter NhaP (NCBI) 220, 490
PA4045 PA4045 hypothetical protein (NCBI) 126, 151
PA4640 mqoB malate:quinone oxidoreductase (NCBI) 398, 490
PA4801 PA4801 hypothetical protein (NCBI) 299, 490
PA5074 PA5074 probable ATP-binding component of ABC transporter (NCBI) 43, 151
PA5075 PA5075 probable permease of ABC transporter (NCBI) 151, 234
PA5250 PA5250 hypothetical protein (NCBI) 151, 480
PA5251 PA5251 hypothetical protein (NCBI) 82, 151
PA5252 PA5252 probable ATP-binding component of ABC transporter (NCBI) 151, 490
PA5351 rubA1 Rubredoxin 1 (NCBI) 117, 490
PA5516 pdxY pyridoxine kinase (NCBI) 151, 387
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for PA5252
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend