Organism : Synechococcus elongatus PCC 7942 | Module List :
Synpcc7942_0349

hypothetical protein

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for Synpcc7942_0349
(Mouseover regulator name to see its description)

Warning: No Regulators were found for Synpcc7942_0349!

Warning: Synpcc7942_0349 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 6 motifs predicted.

Motif Table (6)
Motif Id e-value Consensus Motif Logo
1556 1.00e+04 aTGa.AGAgAAacT
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1557 1.40e+05 GCCtGAAtCAC
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1558 9.10e+04 TTtcCcatgtTgtaGcT.CT
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1634 2.50e+00 TTGtcaaAgTCTTgGGtCAA
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1635 1.70e+02 AtgtTgtTcaaataaCCTaAGGtA
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1636 1.80e+03 CAGCcTA
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for Synpcc7942_0349

Warning: No Functional annotations were found!

Module neighborhood information for Synpcc7942_0349

Synpcc7942_0349 has total of 56 gene neighbors in modules 12, 38
Gene neighbors (56)
Gene Common Name Description Module membership
Synpcc7942_0046 Methylase involved in ubiquinone/menaquinone biosynthesis-like 31, 38
Synpcc7942_0076 "amino acid ABC transporter substrate-binding protein, PAAT family (TC 3.A.1.3.-) (IMGterm)" 12, 163
Synpcc7942_0092 hypothetical protein 2, 12
Synpcc7942_0139 "acetolactate synthase, large subunit (EC 2.2.1.6) (IMGterm)" 38, 181
Synpcc7942_0236 cyclic nucleotide-binding domain (cNMP-BD) protein 38, 180
Synpcc7942_0255 ATPase 38, 121
Synpcc7942_0258 hypothetical protein 12, 41
Synpcc7942_0266 Heat shock protein DnaJ-like 12, 90
Synpcc7942_0276 glycolate oxidase subunit GlcD (EC:1.1.3.15) 38, 90
Synpcc7942_0281 "probable glycosyltransferase (EC:2.7.8.-, EC:2.7.8.-)" 12, 46
Synpcc7942_0349 hypothetical protein 12, 38
Synpcc7942_0360 hypothetical protein 38, 117
Synpcc7942_0365 response regulator receiver domain protein (CheY-like) 12, 90
Synpcc7942_0410 hypothetical protein 38, 181
Synpcc7942_0462 hypothetical protein 12, 130
Synpcc7942_0463 protein tyrosine phosphatase (IMGterm) 12, 130
Synpcc7942_0607 hypothetical protein 38, 94
Synpcc7942_0608 acireductone dioxygenase apoprotein (IMGterm) 38, 107
Synpcc7942_0860 CheW protein (IMGterm) 38, 100
Synpcc7942_0873 hypothetical protein 12, 44
Synpcc7942_0886 SSU ribosomal protein S7P (IMGterm) 12, 141
Synpcc7942_0909 HesB/YadR/YfhF 29, 38
Synpcc7942_0985 hypothetical protein 12, 90
Synpcc7942_1015 methyl-accepting chemotaxis sensory transducer (IMGterm) 38, 117
Synpcc7942_1224 ABC-transporter membrane fusion protein 12, 13
Synpcc7942_1259 arsenite efflux ATP-binding protein ArsA (TC 3.A.4.1.1) (IMGterm) 29, 38
Synpcc7942_1281 hypothetical protein 12, 117
Synpcc7942_1287 VCBS 12, 186
Synpcc7942_1414 ATPase 38, 72
Synpcc7942_1429 hypothetical protein 38, 121
Synpcc7942_1430 hypothetical protein 38, 121
Synpcc7942_1451 hypothetical protein 2, 38
Synpcc7942_1478 cytochrome CytM 12, 122
Synpcc7942_1510 "RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG (IMGterm)" 38, 86
Synpcc7942_1561 hypothetical protein 12, 80
Synpcc7942_1562 ADP-ribosylglycohydrolase-like (EC:3.2.-) 12, 92
Synpcc7942_1578 Sec-independent protein translocase TatC (IMGterm) 12, 72
Synpcc7942_1733 transcriptional regulator (IMGterm) 38, 117
Synpcc7942_1755 hypothetical protein 12, 46
Synpcc7942_1837 hypothetical protein 38, 107
Synpcc7942_1951 hypothetical protein 38, 72
Synpcc7942_1977 NADH dehydrogenase subunit L (EC 1.6.5.3) (IMGterm) 12, 194
Synpcc7942_1983 three-step phytoene desaturase (EC 1.3.99.-) / zeta-carotene desaturase (EC 1.3.99.-) (IMGterm) 12, 140
Synpcc7942_1986 "processing protease (EC:3.4.99.-, EC:3.4.24.64)" 38, 117
Synpcc7942_2144 nuclease (SNase-like) (EC:3.1.31.1) 38, 121
Synpcc7942_2171 starvation induced DNA binding protein 38, 90
Synpcc7942_2190 Methionine sulfoxide reductase B (EC:1.8.4.12) 29, 38
Synpcc7942_2240 conserved hypothetical protein YCF52 38, 90
Synpcc7942_2282 GAF sensor signal transduction histidine kinase (EC 2.7.13.3) (IMGterm) 38, 90
Synpcc7942_2338 hypothetical protein 5, 12
Synpcc7942_2420 serine O-acetyltransferase (EC 2.3.1.30) (IMGterm) 38, 50
Synpcc7942_2423 glucose inhibited division protein A 12, 38
Synpcc7942_2424 hypothetical protein 12, 132
Synpcc7942_2438 "putative CheA signal transduction histidine kinase, no good domain identification" 12, 41
Synpcc7942_2460 DNA-cytosine methyltransferase (EC:2.1.1.37) 12, 31
Synpcc7942_2480 "Prolyl 4-hydroxylase, alpha subunit" 38, 61
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for Synpcc7942_0349
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend