******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.10.0 (Release date: Wed May 21 10:35:36 2014 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= motifs/457/457.seqs.fa ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ 3281 1.0000 500 37417 1.0000 500 47416 1.0000 500 15338 1.0000 500 43442 1.0000 500 49214 1.0000 500 49954 1.0000 500 8141 1.0000 500 51283 1.0000 500 44040 1.0000 500 2432 1.0000 500 7876 1.0000 500 12550 1.0000 500 31861 1.0000 500 34633 1.0000 500 49474 1.0000 500 43906 1.0000 500 43825 1.0000 500 45946 1.0000 500 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme motifs/457/457.seqs.fa -oc motifs/457 -dna -minw 12 -maxw 21 -nmotifs 3 -maxsize 500000 model: mod= zoops nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 12 maxw= 21 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 2 maxsites= 19 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 global: substring= yes branching= no wbranch= no em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 9500 N= 19 strands: + sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.267 C 0.247 G 0.239 T 0.247 Background letter frequencies (from dataset with add-one prior applied): A 0.267 C 0.247 G 0.239 T 0.247 ******************************************************************************** ******************************************************************************** MOTIF 1 MEME width = 19 sites = 11 llr = 153 E-value = 1.8e-002 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A 19a55a211:1319::851 pos.-specific C 1::12:24:9::4:14:36 probability G 81:51:2171974:96:2: matrix T ::::2:552:::21::2:3 bits 2.1 1.9 * * 1.7 * * ** * 1.4 ** * ** ** Relative 1.2 *** * *** ** * Entropy 1.0 *** * **** **** (20.1 bits) 0.8 *** * **** **** * 0.6 **** * **** ****** 0.4 **** * ***** ****** 0.2 ******************* 0.0 ------------------- Multilevel GAAAAATTGCGGCAGGAAC consensus G C AG C CT sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ------------------- 49954 237 2.90e-09 TCCCGGAAGT GAAAAATGGCGGGAGGACC TGTCCAAAAA 49474 445 3.38e-09 GAAGCATGAC GAAGAATTGCGGAAGGAGC TCTAGGAGAA 44040 304 1.70e-08 CATGGCCCCG GAAGCATTGCGACAGGTAC ACACAAGTTA 2432 77 1.12e-07 AGCATGCGCC GAAAAAGCGCAGTAGGAAT GAAACGCCCA 15338 73 1.44e-07 TGTACGGACA GAAGTAACACGGCAGGAGC ACAATCGTCT 51283 112 1.86e-07 GCTCCTCCAA GAAATACTGCGGGAGCTCT TTTCCCACTT 45946 377 2.57e-07 TGAAGACGAA GAAACAGATCGGCAGGAAT CGATCTTTCC 3281 68 2.99e-07 AAACGACAAG GAAGGAATGGGAGAGGAAC CGGAACCGGA 12550 115 5.78e-07 GTCATTTTGC CGACAATCGCGGCAGCAAC CAGACTTTCG 47416 7 5.78e-07 ATATGA AAAGAATTGCGAGTGCACC AAGCGAGGGT 37417 206 1.71e-06 CAATGACTCG GAAAAACCTCGGTACCAAA ATTGCGTAGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 49954 2.9e-09 236_[+1]_245 49474 3.4e-09 444_[+1]_37 44040 1.7e-08 303_[+1]_178 2432 1.1e-07 76_[+1]_405 15338 1.4e-07 72_[+1]_409 51283 1.9e-07 111_[+1]_370 45946 2.6e-07 376_[+1]_105 3281 3e-07 67_[+1]_414 12550 5.8e-07 114_[+1]_367 47416 5.8e-07 6_[+1]_475 37417 1.7e-06 205_[+1]_276 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=19 seqs=11 49954 ( 237) GAAAAATGGCGGGAGGACC 1 49474 ( 445) GAAGAATTGCGGAAGGAGC 1 44040 ( 304) GAAGCATTGCGACAGGTAC 1 2432 ( 77) GAAAAAGCGCAGTAGGAAT 1 15338 ( 73) GAAGTAACACGGCAGGAGC 1 51283 ( 112) GAAATACTGCGGGAGCTCT 1 45946 ( 377) GAAACAGATCGGCAGGAAT 1 3281 ( 68) GAAGGAATGGGAGAGGAAC 1 12550 ( 115) CGACAATCGCGGCAGCAAC 1 47416 ( 7) AAAGAATTGCGAGTGCACC 1 37417 ( 206) GAAAAACCTCGGTACCAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 19 n= 9158 bayes= 10.0551 E= 1.8e-002 -155 -144 178 -1010 177 -1010 -139 -1010 190 -1010 -1010 -1010 77 -144 93 -1010 103 -44 -139 -44 190 -1010 -1010 -1010 -55 -44 -39 88 -155 56 -139 88 -155 -1010 161 -44 -1010 188 -139 -1010 -155 -1010 193 -1010 3 -1010 161 -1010 -155 56 61 -44 177 -1010 -1010 -144 -1010 -144 193 -1010 -1010 56 141 -1010 161 -1010 -1010 -44 103 14 -39 -1010 -155 137 -1010 14 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 19 nsites= 11 E= 1.8e-002 0.090909 0.090909 0.818182 0.000000 0.909091 0.000000 0.090909 0.000000 1.000000 0.000000 0.000000 0.000000 0.454545 0.090909 0.454545 0.000000 0.545455 0.181818 0.090909 0.181818 1.000000 0.000000 0.000000 0.000000 0.181818 0.181818 0.181818 0.454545 0.090909 0.363636 0.090909 0.454545 0.090909 0.000000 0.727273 0.181818 0.000000 0.909091 0.090909 0.000000 0.090909 0.000000 0.909091 0.000000 0.272727 0.000000 0.727273 0.000000 0.090909 0.363636 0.363636 0.181818 0.909091 0.000000 0.000000 0.090909 0.000000 0.090909 0.909091 0.000000 0.000000 0.363636 0.636364 0.000000 0.818182 0.000000 0.000000 0.181818 0.545455 0.272727 0.181818 0.000000 0.090909 0.636364 0.000000 0.272727 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- GAA[AG]AAT[TC]GCG[GA][CG]AG[GC]A[AC][CT] -------------------------------------------------------------------------------- Time 3.40 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 MEME width = 12 sites = 16 llr = 156 E-value = 7.6e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A :11::::1:::: pos.-specific C 812:2:22::81 probability G 233::a3:7::9 matrix T 154a8:573a31 bits 2.1 * * * 1.9 * * * 1.7 * * * 1.4 * * * * Relative 1.2 *** **** Entropy 1.0 * *** **** (14.0 bits) 0.8 * *** ***** 0.6 * ********* 0.4 ** ********* 0.2 ************ 0.0 ------------ Multilevel CTTTTGTTGTCG consensus GG G T T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ------------ 49954 31 9.19e-08 GGTTCATCAA CTGTTGTTGTCG ATTTATGACC 45946 223 4.09e-07 CAGGCCAATC CTTTTGTTTTCG GGATAAGTGG 12550 202 8.22e-07 AAAGTCAGGA CTATTGTTGTCG ATCTAGCGAC 37417 47 1.28e-06 GCAAACTCTG CTTTCGTTGTCG TTTCATGGAT 43825 69 4.23e-06 TAGCTATTCT GGTTTGGTGTCG GCGCCGCGCA 49474 95 9.54e-06 GGTCATCTTC CAGTTGTCGTCG TGGGCAGGGC 3281 189 9.54e-06 TCCTTGTTGA GGCTTGGTGTCG ATCATGGTTG 15338 270 1.67e-05 CTTGCAAGCA CTCTTGCAGTCG GCACAAATGC 2432 289 1.80e-05 TCTATAGAGT GGCTTGTTGTTG GCAATTACAT 31861 312 1.95e-05 CGTGGGTTTC CAGTTGTTTTTG GTTTCACTTA 43442 100 2.73e-05 GCCTGTGTCT CGATTGTCGTTG GCTTCGCTGC 44040 126 3.17e-05 AAACCTCCCG CGTTCGGAGTCG GCCAAAGGTT 47416 107 3.97e-05 GGCTTCTGTA TTTTTGCTTTCG GATGTCGGAA 7876 265 5.54e-05 GCGTGGACAC CTGTTGCTGTTC CATTACGTCG 49214 274 6.23e-05 AGCGTTTCGC CCGTCGGTTTCG TCCAACCGGA 51283 449 7.52e-05 ATTGATATTC CTTTTGGCTTCT GGAACAAAAT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 49954 9.2e-08 30_[+2]_458 45946 4.1e-07 222_[+2]_266 12550 8.2e-07 201_[+2]_287 37417 1.3e-06 46_[+2]_442 43825 4.2e-06 68_[+2]_420 49474 9.5e-06 94_[+2]_394 3281 9.5e-06 188_[+2]_300 15338 1.7e-05 269_[+2]_219 2432 1.8e-05 288_[+2]_200 31861 1.9e-05 311_[+2]_177 43442 2.7e-05 99_[+2]_389 44040 3.2e-05 125_[+2]_363 47416 4e-05 106_[+2]_382 7876 5.5e-05 264_[+2]_224 49214 6.2e-05 273_[+2]_215 51283 7.5e-05 448_[+2]_40 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=12 seqs=16 49954 ( 31) CTGTTGTTGTCG 1 45946 ( 223) CTTTTGTTTTCG 1 12550 ( 202) CTATTGTTGTCG 1 37417 ( 47) CTTTCGTTGTCG 1 43825 ( 69) GGTTTGGTGTCG 1 49474 ( 95) CAGTTGTCGTCG 1 3281 ( 189) GGCTTGGTGTCG 1 15338 ( 270) CTCTTGCAGTCG 1 2432 ( 289) GGCTTGTTGTTG 1 31861 ( 312) CAGTTGTTTTTG 1 43442 ( 100) CGATTGTCGTTG 1 44040 ( 126) CGTTCGGAGTCG 1 47416 ( 107) TTTTTGCTTTCG 1 7876 ( 265) CTGTTGCTGTTC 1 49214 ( 274) CCGTCGGTTTCG 1 51283 ( 449) CTTTTGGCTTCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 12 n= 9291 bayes= 10.5026 E= 7.6e-001 -1064 160 -35 -198 -109 -198 39 101 -109 -40 39 60 -1064 -1064 -1064 201 -1064 -40 -1064 172 -1064 -1064 207 -1064 -1064 -40 39 101 -109 -40 -1064 147 -1064 -1064 153 34 -1064 -1064 -1064 201 -1064 160 -1064 2 -1064 -198 187 -198 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 12 nsites= 16 E= 7.6e-001 0.000000 0.750000 0.187500 0.062500 0.125000 0.062500 0.312500 0.500000 0.125000 0.187500 0.312500 0.375000 0.000000 0.000000 0.000000 1.000000 0.000000 0.187500 0.000000 0.812500 0.000000 0.000000 1.000000 0.000000 0.000000 0.187500 0.312500 0.500000 0.125000 0.187500 0.000000 0.687500 0.000000 0.000000 0.687500 0.312500 0.000000 0.000000 0.000000 1.000000 0.000000 0.750000 0.000000 0.250000 0.000000 0.062500 0.875000 0.062500 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- C[TG][TG]TTG[TG]T[GT]T[CT]G -------------------------------------------------------------------------------- Time 6.82 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 MEME width = 16 sites = 17 llr = 177 E-value = 4.8e+001 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A 61213:6:::611::: pos.-specific C 46:1652:::252:21 probability G :14::4:4:5:11a:5 matrix T :2481126a5236:84 bits 2.1 * * 1.9 * * 1.7 * * 1.4 * ** Relative 1.2 * * ** Entropy 1.0 * * *** ** (15.0 bits) 0.8 * ** *** ** 0.6 ** ******** **** 0.4 **************** 0.2 **************** 0.0 ---------------- Multilevel ACTTCCATTTACTGTG consensus CTG AGCG GCT T sequence A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- ---------------- 43442 12 2.45e-08 TCATTGGAAG ATGTCCATTTACTGTG GATTTTGCGT 45946 338 4.34e-08 GAAACATGGA ACTTCGATTGACCGTG GCAGTTAATT 47416 469 7.41e-07 AAGTCACCTC ACGTCCATTTTCCGTT GCTCACGTCA 8141 97 8.46e-07 AAGCCCCCCA ACGACGCTTGACTGTG AAGCACCAGC 31861 329 1.21e-06 TTTTGGTTTC ACTTACAGTTACTGCT ACGAATTGAC 51283 41 2.40e-06 TCCGTCGCTA CTTTCCTTTGTCTGTG CAACTATGGA 37417 273 2.99e-06 CGAGCCTTTA CTATACCTTGACTGTG GATCCAATGC 43825 331 3.66e-06 TAAACGAACC CCTTAGAGTTACAGTT ACGATTCACA 49954 189 4.45e-06 CATGGTATCG ACTCACAGTTACTGTT AGTCAATTTT 49214 332 4.92e-06 TCTGTGTTCC ACGTCTTTTTATCGTG TGTTGTGTGC 49474 282 1.64e-05 GGCATCCTTG CCGTAGCTTTTTTGTC GTGTTCAACA 34633 438 2.21e-05 TCGACACAAG ATTTCTCTTTCATGTT CCTGTTAACA 12550 391 2.37e-05 GACGAAAACT ACAACCTTTGCATGTG GAGAGGTATC 2432 316 2.72e-05 TACATTATTG ACTTTGAGTTCTTGCT GAACGAAATT 3281 151 2.91e-05 AAAGCTACAA CAATCCAGTGATTGTC TCTTGTTGTG 43906 80 3.33e-05 GTTTGCTTGA CGATCGATTGATGGTG GGCGATATTA 7876 417 4.82e-05 TGTCTGGGCC ACGTCGAGTGCGAGCG TCGCCACGTC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 43442 2.4e-08 11_[+3]_473 45946 4.3e-08 337_[+3]_147 47416 7.4e-07 468_[+3]_16 8141 8.5e-07 96_[+3]_388 31861 1.2e-06 328_[+3]_156 51283 2.4e-06 40_[+3]_444 37417 3e-06 272_[+3]_212 43825 3.7e-06 330_[+3]_154 49954 4.5e-06 188_[+3]_296 49214 4.9e-06 331_[+3]_153 49474 1.6e-05 281_[+3]_203 34633 2.2e-05 437_[+3]_47 12550 2.4e-05 390_[+3]_94 2432 2.7e-05 315_[+3]_169 3281 2.9e-05 150_[+3]_334 43906 3.3e-05 79_[+3]_405 7876 4.8e-05 416_[+3]_68 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=16 seqs=17 43442 ( 12) ATGTCCATTTACTGTG 1 45946 ( 338) ACTTCGATTGACCGTG 1 47416 ( 469) ACGTCCATTTTCCGTT 1 8141 ( 97) ACGACGCTTGACTGTG 1 31861 ( 329) ACTTACAGTTACTGCT 1 51283 ( 41) CTTTCCTTTGTCTGTG 1 37417 ( 273) CTATACCTTGACTGTG 1 43825 ( 331) CCTTAGAGTTACAGTT 1 49954 ( 189) ACTCACAGTTACTGTT 1 49214 ( 332) ACGTCTTTTTATCGTG 1 49474 ( 282) CCGTAGCTTTTTTGTC 1 34633 ( 438) ATTTCTCTTTCATGTT 1 12550 ( 391) ACAACCTTTGCATGTG 1 2432 ( 316) ACTTTGAGTTCTTGCT 1 3281 ( 151) CAATCCAGTGATTGTC 1 43906 ( 80) CGATCGATTGATGGTG 1 7876 ( 417) ACGTCGAGTGCGAGCG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 16 n= 9215 bayes= 9.87545 E= 4.8e+001 128 52 -1073 -1073 -218 139 -202 -7 -18 -1073 56 73 -118 -207 -1073 173 14 139 -1073 -207 -1073 93 79 -107 114 -7 -1073 -49 -1073 -1073 56 139 -1073 -1073 -1073 201 -1073 -1073 98 110 114 -7 -1073 -49 -118 110 -202 25 -118 -48 -202 139 -1073 -1073 207 -1073 -1073 -48 -1073 173 -1073 -107 115 51 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 16 nsites= 17 E= 4.8e+001 0.647059 0.352941 0.000000 0.000000 0.058824 0.647059 0.058824 0.235294 0.235294 0.000000 0.352941 0.411765 0.117647 0.058824 0.000000 0.823529 0.294118 0.647059 0.000000 0.058824 0.000000 0.470588 0.411765 0.117647 0.588235 0.235294 0.000000 0.176471 0.000000 0.000000 0.352941 0.647059 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.470588 0.529412 0.588235 0.235294 0.000000 0.176471 0.117647 0.529412 0.058824 0.294118 0.117647 0.176471 0.058824 0.647059 0.000000 0.000000 1.000000 0.000000 0.000000 0.176471 0.000000 0.823529 0.000000 0.117647 0.529412 0.352941 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- [AC][CT][TGA]T[CA][CG][AC][TG]T[TG][AC][CT]TGT[GT] -------------------------------------------------------------------------------- Time 10.05 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 3281 1.79e-06 67_[+1(2.99e-07)]_64_[+3(2.91e-05)]_\ 22_[+2(9.54e-06)]_300 37417 1.81e-07 46_[+2(1.28e-06)]_147_\ [+1(1.71e-06)]_48_[+3(2.99e-06)]_212 47416 4.29e-07 6_[+1(5.78e-07)]_81_[+2(3.97e-05)]_\ 350_[+3(7.41e-07)]_16 15338 6.28e-05 72_[+1(1.44e-07)]_178_\ [+2(1.67e-05)]_219 43442 1.21e-05 11_[+3(2.45e-08)]_72_[+2(2.73e-05)]_\ 389 49214 6.48e-04 273_[+2(6.23e-05)]_46_\ [+3(4.92e-06)]_153 49954 6.38e-11 30_[+2(9.19e-08)]_146_\ [+3(4.45e-06)]_32_[+1(2.90e-09)]_245 8141 4.15e-03 96_[+3(8.46e-07)]_388 51283 7.87e-07 40_[+3(2.40e-06)]_55_[+1(1.86e-07)]_\ 318_[+2(7.52e-05)]_40 44040 1.20e-05 125_[+2(3.17e-05)]_166_\ [+1(1.70e-08)]_178 2432 1.23e-06 76_[+1(1.12e-07)]_193_\ [+2(1.80e-05)]_15_[+3(2.72e-05)]_169 7876 9.47e-03 264_[+2(5.54e-05)]_140_\ [+3(4.82e-05)]_68 12550 2.96e-07 114_[+1(5.78e-07)]_68_\ [+2(8.22e-07)]_177_[+3(2.37e-05)]_94 31861 3.39e-04 311_[+2(1.95e-05)]_5_[+3(1.21e-06)]_\ 156 34633 1.41e-01 437_[+3(2.21e-05)]_47 49474 1.81e-08 94_[+2(9.54e-06)]_175_\ [+3(1.64e-05)]_147_[+1(3.38e-09)]_37 43906 7.55e-02 79_[+3(3.33e-05)]_405 43825 1.55e-04 68_[+2(4.23e-06)]_250_\ [+3(3.66e-06)]_154 45946 2.24e-10 222_[+2(4.09e-07)]_103_\ [+3(4.34e-08)]_23_[+1(2.57e-07)]_105 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 3 reached. ******************************************************************************** CPU: seaotter.hsd1.wa.comcast.net ********************************************************************************