******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.10.0 (Release date: Wed May 21 10:35:36 2014 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= motifs/367/367.seqs.fa ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ 10142 1.0000 500 22199 1.0000 500 2436 1.0000 500 262395 1.0000 500 263819 1.0000 500 264111 1.0000 500 31362 1.0000 500 33340 1.0000 500 34595 1.0000 500 411 1.0000 500 5083 1.0000 500 7141 1.0000 500 7656 1.0000 500 8101 1.0000 500 8844 1.0000 500 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme motifs/367/367.seqs.fa -oc motifs/367 -dna -minw 12 -maxw 21 -nmotifs 3 -maxsize 500000 model: mod= zoops nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 12 maxw= 21 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 2 maxsites= 15 wnsites= 0.8 theta: prob= 1 spmap= uni spfuzz= 0.5 global: substring= yes branching= no wbranch= no em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 data: n= 7500 N= 15 strands: + sample: seed= 0 seqfrac= 1 Letter frequencies in dataset: A 0.258 C 0.221 G 0.260 T 0.262 Background letter frequencies (from dataset with add-one prior applied): A 0.258 C 0.221 G 0.260 T 0.262 ******************************************************************************** ******************************************************************************** MOTIF 1 MEME width = 21 sites = 10 llr = 152 E-value = 2.7e-002 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A :921661a1:6::61172:46 pos.-specific C 1:::123:5:1a:141:::1: probability G 8139::6:2a::a:2838451 matrix T 1:5:32::2:3::33:::6:3 bits 2.2 * 2.0 * * ** 1.7 * * ** 1.5 * * * * ** Relative 1.3 * * * * ** * Entropy 1.1 ** * * * ** *** (21.9 bits) 0.9 ** * * * ** **** 0.7 ** ***** ***** ****** 0.4 ******** ***** ****** 0.2 ********************* 0.0 --------------------- Multilevel GATGAAGACGACGACGAGTGA consensus G TCC G T TT GAGAT sequence A T T G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 34595 312 1.18e-09 AGGAAGAGGA GATGATGACGACGATGAATAA AAATCCAAAC 10142 302 3.93e-09 GACGCAAGAC GAGATACACGACGACGAGTGA TACTACATTC 7656 175 5.59e-09 GACGCAGTTA GATGAAAACGACGAAGGGTGA AGTGTGGTAG 8101 393 6.35e-09 AGAAGGAAGA GATGACGACGACGAGGAGGAG GAGGTGCTAC 263819 239 2.14e-08 GTGATGTGCT GATGATGATGACGCCGAGGAT AGCGGCGAGG 31362 88 4.58e-08 GGCTGATCTG TATGACGAAGTCGACGAGGGA GGTGCTGACG 2436 333 7.04e-08 TGCGAGATGG GAGGTAGACGACGTGAGGTGT GTGGATTTGC 7141 240 2.54e-07 CGTTTGTTGT GGGGTACATGTCGTTGAGTAT GGTTTGGTAT 5083 175 2.70e-07 TGACTAGAAA CAAGAAGAGGCCGATCAGTGA TGAAAAGACG 262395 317 8.99e-07 CTGTGACACA GAAGCACAGGTCGTCGGAGCA GGCTAAACCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 34595 1.2e-09 311_[+1]_168 10142 3.9e-09 301_[+1]_178 7656 5.6e-09 174_[+1]_305 8101 6.4e-09 392_[+1]_87 263819 2.1e-08 238_[+1]_241 31362 4.6e-08 87_[+1]_392 2436 7e-08 332_[+1]_147 7141 2.5e-07 239_[+1]_240 5083 2.7e-07 174_[+1]_305 262395 9e-07 316_[+1]_163 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=21 seqs=10 34595 ( 312) GATGATGACGACGATGAATAA 1 10142 ( 302) GAGATACACGACGACGAGTGA 1 7656 ( 175) GATGAAAACGACGAAGGGTGA 1 8101 ( 393) GATGACGACGACGAGGAGGAG 1 263819 ( 239) GATGATGATGACGCCGAGGAT 1 31362 ( 88) TATGACGAAGTCGACGAGGGA 1 2436 ( 333) GAGGTAGACGACGTGAGGTGT 1 7141 ( 240) GGGGTACATGTCGTTGAGTAT 1 5083 ( 175) CAAGAAGAGGCCGATCAGTGA 1 262395 ( 317) GAAGCACAGGTCGTCGGAGCA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 7200 bayes= 9.74171 E= 2.7e-002 -997 -114 162 -139 180 -997 -137 -997 -37 -997 21 93 -137 -997 179 -997 122 -114 -997 20 122 -14 -997 -39 -137 44 121 -997 195 -997 -997 -997 -137 118 -38 -39 -997 -997 194 -997 122 -114 -997 20 -997 218 -997 -997 -997 -997 194 -997 122 -114 -997 20 -137 86 -38 20 -137 -114 162 -997 144 -997 21 -997 -37 -997 162 -997 -997 -997 62 120 63 -114 94 -997 122 -997 -137 20 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 10 E= 2.7e-002 0.000000 0.100000 0.800000 0.100000 0.900000 0.000000 0.100000 0.000000 0.200000 0.000000 0.300000 0.500000 0.100000 0.000000 0.900000 0.000000 0.600000 0.100000 0.000000 0.300000 0.600000 0.200000 0.000000 0.200000 0.100000 0.300000 0.600000 0.000000 1.000000 0.000000 0.000000 0.000000 0.100000 0.500000 0.200000 0.200000 0.000000 0.000000 1.000000 0.000000 0.600000 0.100000 0.000000 0.300000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.600000 0.100000 0.000000 0.300000 0.100000 0.400000 0.200000 0.300000 0.100000 0.100000 0.800000 0.000000 0.700000 0.000000 0.300000 0.000000 0.200000 0.000000 0.800000 0.000000 0.000000 0.000000 0.400000 0.600000 0.400000 0.100000 0.500000 0.000000 0.600000 0.000000 0.100000 0.300000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- GA[TGA]G[AT][ACT][GC]A[CGT]G[AT]CG[AT][CTG]G[AG][GA][TG][GA][AT] -------------------------------------------------------------------------------- Time 1.79 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 MEME width = 20 sites = 10 llr = 145 E-value = 7.9e-002 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A 1633a7:343a5:8622372 pos.-specific C 8236::a717:1a:284623 probability G 1:4::2::3::1:::::::: matrix T :2:1:1::2::3:22:4115 bits 2.2 * * 2.0 * * * * 1.7 * * * * 1.5 * * * * Relative 1.3 * * ** ** ** * Entropy 1.1 * * ** ** ** * (20.9 bits) 0.9 * ***** ** ** * ** 0.7 ** ***** ** **** ** 0.4 ******** ** ******** 0.2 ******************** 0.0 -------------------- Multilevel CAGCAACCACAACAACCCAT consensus CAA G AGA T TCATACC sequence TC T T A A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------------------- 8101 438 3.81e-09 TTCTGACGCT CAGCAACCCCAGCAACTCAC TAAAAAATAA 31362 476 1.38e-08 ACATTCGCCG CACAAACCTCAACTACCAAC AAACC 10142 473 2.44e-08 TAAAACCTCG CAACATCCACAACAAAACAT TGAACAAC 8844 478 5.09e-08 GGGCACAACA CAACAACAGAAACAACAAAA ATA 411 153 5.09e-08 GTCTTTCGGT CACCAACCGCATCATCTTCT TGTTCCGTCT 262395 146 6.18e-08 AGCACGCAGA CAGCAGCCACATCTCCTCCT TCACCCACCG 2436 420 1.08e-07 AAGTTCAAAC ACACAACCTCAACACCCAAT CTGCGCACCG 7141 386 3.86e-07 CCGTCCTCCA CCGTAACAAAAACAACCCTC TGAACCAACG 263819 476 3.86e-07 AGTCCGTCAC CTCAAACAAAATCATACCAT CAACA 33340 6 8.39e-07 AAGCG GTGAAGCCGCACCAACTCAA AACGCCTCTC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 8101 3.8e-09 437_[+2]_43 31362 1.4e-08 475_[+2]_5 10142 2.4e-08 472_[+2]_8 8844 5.1e-08 477_[+2]_3 411 5.1e-08 152_[+2]_328 262395 6.2e-08 145_[+2]_335 2436 1.1e-07 419_[+2]_61 7141 3.9e-07 385_[+2]_95 263819 3.9e-07 475_[+2]_5 33340 8.4e-07 5_[+2]_475 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=20 seqs=10 8101 ( 438) CAGCAACCCCAGCAACTCAC 1 31362 ( 476) CACAAACCTCAACTACCAAC 1 10142 ( 473) CAACATCCACAACAAAACAT 1 8844 ( 478) CAACAACAGAAACAACAAAA 1 411 ( 153) CACCAACCGCATCATCTTCT 1 262395 ( 146) CAGCAGCCACATCTCCTCCT 1 2436 ( 420) ACACAACCTCAACACCCAAT 1 7141 ( 386) CCGTAACAAAAACAACCCTC 1 263819 ( 476) CTCAAACAAAATCATACCAT 1 33340 ( 6) GTGAAGCCGCACCAACTCAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 20 n= 7215 bayes= 10.4372 E= 7.9e-002 -137 186 -137 -997 122 -14 -997 -39 22 44 62 -997 22 144 -997 -139 195 -997 -997 -997 144 -997 -38 -139 -997 218 -997 -997 22 166 -997 -997 63 -114 21 -39 22 166 -997 -997 195 -997 -997 -997 95 -114 -137 20 -997 218 -997 -997 163 -997 -997 -39 122 -14 -997 -39 -37 186 -997 -997 -37 86 -997 61 22 144 -997 -139 144 -14 -997 -139 -37 44 -997 93 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 20 nsites= 10 E= 7.9e-002 0.100000 0.800000 0.100000 0.000000 0.600000 0.200000 0.000000 0.200000 0.300000 0.300000 0.400000 0.000000 0.300000 0.600000 0.000000 0.100000 1.000000 0.000000 0.000000 0.000000 0.700000 0.000000 0.200000 0.100000 0.000000 1.000000 0.000000 0.000000 0.300000 0.700000 0.000000 0.000000 0.400000 0.100000 0.300000 0.200000 0.300000 0.700000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.500000 0.100000 0.100000 0.300000 0.000000 1.000000 0.000000 0.000000 0.800000 0.000000 0.000000 0.200000 0.600000 0.200000 0.000000 0.200000 0.200000 0.800000 0.000000 0.000000 0.200000 0.400000 0.000000 0.400000 0.300000 0.600000 0.000000 0.100000 0.700000 0.200000 0.000000 0.100000 0.200000 0.300000 0.000000 0.500000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- C[ACT][GAC][CA]A[AG]C[CA][AGT][CA]A[AT]C[AT][ACT][CA][CTA][CA][AC][TCA] -------------------------------------------------------------------------------- Time 3.84 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 MEME width = 21 sites = 15 llr = 180 E-value = 8.6e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A ::6:3113:41::1:::22:: pos.-specific C :11121:::111111631242 probability G 2733317:91:8:14117:17 matrix T 83:73827148197536:651 bits 2.2 2.0 1.7 1.5 Relative 1.3 * * * Entropy 1.1 * ** *** (17.3 bits) 0.9 ** * **** *** ** 0.7 **** **** *********** 0.4 **** **** *********** 0.2 **** **************** 0.0 --------------------- Multilevel TGATATGTGATGTTTCTGTTG consensus GTGGG TA T GTCAACC sequence T C C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- 33340 365 4.88e-10 GTTAAGTTTG TGATGTGTGTTGTTGGTGTTG TTGTTGATTG 263819 309 8.20e-10 CGTTCTAGCA TTATTTTTGTTGTTTCTGTTG TTGTGTTGTG 22199 226 2.86e-08 CGTTGAGCTC TGGTGTGAGGTGTTTCTATCG GTACCATCAA 8844 190 1.55e-07 AGAGAGCTGC TGATGTTTTGTGTTGTTGTCG GCTCATGGTT 31362 276 4.21e-07 TTGATGTGTT GGAGACGTGTTGTTGCCGACG GATGTAACGA 34595 120 7.33e-07 TGAGTTCGTT TGACCTGTGCTCTTTCCGATG TTTGCTTTCA 7656 219 1.04e-06 ATGTGAGGGG GGCGATGTGTTGTTTTTGCCT GCTGGCTGCG 8101 264 1.47e-06 GAAACGAGGG TCGGGTGAGATCTTTCTGTCC TCTAGAAATT 10142 4 1.47e-06 TAA TGATATATGATGTCTCTCTTT CTGTGAATTA 262395 437 1.73e-06 TGTGTTCAAA GTGTATGTGAAGTCTTCGTTG CATACAGACT 5083 432 4.11e-06 TTTCCGATGT TGATTTGTGTATCTTCCAATG ACTATGAGTT 2436 213 4.76e-06 GGTGTAGTAA TGAGCTGTTACGTTGGCATCG TAAAGGAAAG 411 82 6.81e-06 AAGAACTCGC TTATTTGAGATGTGCCGGTTC TTGCCTCGTT 264111 336 1.33e-05 ATGTATCGTT TGGTTGGAGATGTAGTTGCGG CAGGTGGAGC 7141 72 3.65e-05 CAGATATCAT TTCTCATTGTTGCAGCTGCTC TCTCTTTGCT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 33340 4.9e-10 364_[+3]_115 263819 8.2e-10 308_[+3]_171 22199 2.9e-08 225_[+3]_254 8844 1.6e-07 189_[+3]_290 31362 4.2e-07 275_[+3]_204 34595 7.3e-07 119_[+3]_360 7656 1e-06 218_[+3]_261 8101 1.5e-06 263_[+3]_216 10142 1.5e-06 3_[+3]_476 262395 1.7e-06 436_[+3]_43 5083 4.1e-06 431_[+3]_48 2436 4.8e-06 212_[+3]_267 411 6.8e-06 81_[+3]_398 264111 1.3e-05 335_[+3]_144 7141 3.6e-05 71_[+3]_408 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=21 seqs=15 33340 ( 365) TGATGTGTGTTGTTGGTGTTG 1 263819 ( 309) TTATTTTTGTTGTTTCTGTTG 1 22199 ( 226) TGGTGTGAGGTGTTTCTATCG 1 8844 ( 190) TGATGTTTTGTGTTGTTGTCG 1 31362 ( 276) GGAGACGTGTTGTTGCCGACG 1 34595 ( 120) TGACCTGTGCTCTTTCCGATG 1 7656 ( 219) GGCGATGTGTTGTTTTTGCCT 1 8101 ( 264) TCGGGTGAGATCTTTCTGTCC 1 10142 ( 4) TGATATATGATGTCTCTCTTT 1 262395 ( 437) GTGTATGTGAAGTCTTCGTTG 1 5083 ( 432) TGATTTGTGTATCTTCCAATG 1 2436 ( 213) TGAGCTGTTACGTTGGCATCG 1 411 ( 82) TTATTTGAGATGTGCCGGTTC 1 264111 ( 336) TGGTTGGAGATGTAGTTGCGG 1 7141 ( 72) TTCTCATTGTTGCAGCTGCTC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 21 n= 7200 bayes= 8.90388 E= 8.6e-001 -1055 -1055 -38 161 -1055 -172 136 3 122 -73 4 -1055 -1055 -172 4 135 5 -14 4 3 -195 -172 -196 161 -195 -1055 150 -39 5 -1055 -1055 149 -1055 -1055 174 -97 63 -172 -96 61 -95 -172 -1055 161 -1055 -73 162 -197 -1055 -73 -1055 173 -95 -73 -196 135 -1055 -172 62 103 -1055 144 -96 3 -1055 59 -196 120 -37 -172 150 -1055 -37 -14 -1055 120 -1055 86 -196 103 -1055 -14 136 -97 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 21 nsites= 15 E= 8.6e-001 0.000000 0.000000 0.200000 0.800000 0.000000 0.066667 0.666667 0.266667 0.600000 0.133333 0.266667 0.000000 0.000000 0.066667 0.266667 0.666667 0.266667 0.200000 0.266667 0.266667 0.066667 0.066667 0.066667 0.800000 0.066667 0.000000 0.733333 0.200000 0.266667 0.000000 0.000000 0.733333 0.000000 0.000000 0.866667 0.133333 0.400000 0.066667 0.133333 0.400000 0.133333 0.066667 0.000000 0.800000 0.000000 0.133333 0.800000 0.066667 0.000000 0.133333 0.000000 0.866667 0.133333 0.133333 0.066667 0.666667 0.000000 0.066667 0.400000 0.533333 0.000000 0.600000 0.133333 0.266667 0.000000 0.333333 0.066667 0.600000 0.200000 0.066667 0.733333 0.000000 0.200000 0.200000 0.000000 0.600000 0.000000 0.400000 0.066667 0.533333 0.000000 0.200000 0.666667 0.133333 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- [TG][GT][AG][TG][AGTC]T[GT][TA]G[AT]TGTT[TG][CT][TC][GA][TAC][TC][GC] -------------------------------------------------------------------------------- Time 5.56 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- 10142 8.38e-12 3_[+3(1.47e-06)]_132_[+2(8.30e-06)]_\ 42_[+2(4.25e-05)]_63_[+1(3.93e-09)]_150_[+2(2.44e-08)]_8 22199 6.12e-05 225_[+3(2.86e-08)]_254 2436 1.49e-09 212_[+3(4.76e-06)]_99_\ [+1(7.04e-08)]_66_[+2(1.08e-07)]_61 262395 3.69e-09 145_[+2(6.18e-08)]_151_\ [+1(8.99e-07)]_99_[+3(1.73e-06)]_43 263819 4.81e-13 118_[+1(1.52e-05)]_99_\ [+1(2.14e-08)]_49_[+3(8.20e-10)]_146_[+2(3.86e-07)]_5 264111 3.95e-02 335_[+3(1.33e-05)]_144 31362 1.52e-11 87_[+1(4.58e-08)]_63_[+1(3.39e-05)]_\ 83_[+3(4.21e-07)]_105_[+2(4.71e-06)]_54_[+2(1.38e-08)]_5 33340 1.55e-08 5_[+2(8.39e-07)]_339_[+3(4.88e-10)]_\ 115 34595 2.00e-08 119_[+3(7.33e-07)]_171_\ [+1(1.18e-09)]_168 411 5.46e-06 81_[+3(6.81e-06)]_50_[+2(5.09e-08)]_\ 328 5083 3.31e-05 174_[+1(2.70e-07)]_236_\ [+3(4.11e-06)]_48 7141 1.01e-07 71_[+3(3.65e-05)]_147_\ [+1(2.54e-07)]_15_[+2(5.68e-05)]_90_[+2(3.86e-07)]_95 7656 3.05e-07 119_[+1(4.39e-06)]_34_\ [+1(5.59e-09)]_23_[+3(1.04e-06)]_261 8101 2.30e-12 263_[+3(1.47e-06)]_108_\ [+1(6.35e-09)]_24_[+2(3.81e-09)]_43 8844 9.82e-08 189_[+3(1.55e-07)]_267_\ [+2(5.09e-08)]_3 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 3 reached. ******************************************************************************** CPU: seaotter.hsd1.wa.comcast.net ********************************************************************************