Module Functions 1 "Chromatin structure and dynamics:Chromatin structure and dynamics:Deacetylases, including yeast histone deacetylase and acetoin utilization protein:Deacetylases, including yeast histone deacetylase and acetoin utilization protein:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Mismatch repair ATPase (MutS family):Mismatch repair ATPase (MutS family):ABC-type transport system involved in resistance to organic solvents, auxiliary component:ABC-type transport system involved in resistance to organic solvents, auxiliary component:signal transducer activity:iron ion binding:ATP binding:electron transport:mismatch repair:cellular amino acid metabolic process:chemotaxis:signal transduction:electron carrier activity:oxidoreductase activity:heme binding:mismatched DNA binding:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Mismatch repair:Mismatch repair:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:Signal transduction mechanisms:Signal transduction mechanisms:Signal Transduction:Cellular Processes:Cell Motility:Information storage and processing:Cellular processes and signaling:Metabolism:Cellular Processes:Environmental Information Processing:Genetic Information Processing:Cell Motility:Signal Transduction:Information storage and processing:Replication and Repair:Cellular processes and signaling:Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing" 2 "ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:DNA polymerase III, epsilon subunit and related 3'-5' exonucleases:DNA polymerase III, epsilon subunit and related 3'-5' exonucleases:Predicted ATPase:Predicted ATPase:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Amino acid transport and metabolism:nucleic acid binding:DNA-directed DNA polymerase activity:exonuclease activity:ATP binding:ATPase activity:Replication, recombination and repair:Replication, recombination and repair:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:DNA replication:DNA replication:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Function unknown:Function unknown:primase_Cterm:primase_Cterm:Global:Metabolism:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Metabolism:Poorly characterized:Membrane Transport:Replication and Repair:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:Prophage functions:Mobile and extrachromosomal element functions:Nucleotide Metabolism:Information storage and processing:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport" 3 "ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:Predicted transcriptional regulators:Predicted transcriptional regulators:Chromate transport protein ChrA:Chromate transport protein ChrA:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:ATP binding:DNA repair:regulation of transcription, DNA-dependent:cell cycle:cyclic nucleotide biosynthetic process:peptidoglycan biosynthetic process:chromate transmembrane transporter activity:chromate transport:transferase activity, transferring pentosyl groups:phosphorus-oxygen lyase activity:ATPase activity:intracellular signal transduction:Transcription:Transcription:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:2A51:2A51:mono_pep_trsgly:mono_pep_trsgly:Transport and binding proteins:Anions:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Glycan Biosynthesis and Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Anions:Regulatory functions:Transport and binding proteins:Cell envelope:Small molecule interactions:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Glycan Biosynthesis and Metabolism:Regulatory functions:Small molecule interactions" 4 "Cysteine synthase:Cysteine synthase:Dihydroorotate dehydrogenase:Dihydroorotate dehydrogenase:DNA mismatch repair enzyme (predicted ATPase):DNA mismatch repair enzyme (predicted ATPase):ATPases with chaperone activity, ATP-binding subunit:ATPases with chaperone activity, ATP-binding subunit:Exoribonuclease R:Exoribonuclease R:Molecular chaperone GrpE (heat shock protein):Molecular chaperone GrpE (heat shock protein):Membrane-fusion protein:Membrane-fusion protein:Serine acetyltransferase:Serine acetyltransferase:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Highly conserved protein containing a thioredoxin domain:Highly conserved protein containing a thioredoxin domain:Uncharacterized conserved protein:Uncharacterized conserved protein:Outer membrane protein:Outer membrane protein:Ribosome-associated protein Y (PSrp-1):Ribosome-associated protein Y (PSrp-1):Tetraacyldisaccharide-1-P 4'-kinase:Tetraacyldisaccharide-1-P 4'-kinase:Cation transport ATPase:Cation transport ATPase:Protein affecting phage T7 exclusion by the F plasmid:Protein affecting phage T7 exclusion by the F plasmid:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:adenyl-nucleotide exchange factor activity:DNA binding:RNA binding:protein disulfide isomerase activity:catalytic activity:copper-exporting ATPase activity:cysteine synthase activity:dihydroorotate dehydrogenase activity:dihydroorotate oxidase activity:dihydrouracil dehydrogenase (NAD+) activity:cysteine-type endopeptidase activity:ribonuclease activity:thymidylate kinase activity:transporter activity:copper ion binding:protein binding:ATP binding:'de novo' pyrimidine base biosynthetic process:UMP biosynthetic process:mismatch repair:mRNA catabolic process:protein folding:proteolysis:cysteine biosynthetic process from serine:glycerol ether metabolic process:copper ion transport:metabolic process:endopeptidase Clp activity:transaminase activity:protein transporter activity:exoribonuclease II activity:ribonuclease R activity:serine O-acetyltransferase activity:tetraacyldisaccharide 4'-kinase activity:electron carrier activity:lipid A biosynthetic process:protein secretion:protein transport:protein disulfide oxidoreductase activity:RNA metabolic process:nucleoside-triphosphatase activity:pyridoxal phosphate binding:mismatched DNA binding:cysteine desulfurase activity:protein homodimerization activity:cell redox homeostasis:metal ion transmembrane transporter activity:chaperone mediated protein folding requiring cofactor:chaperone binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Selenocompound metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Thiamine metabolism:Thiamine metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:RNA degradation:RNA degradation:Mismatch repair:Mismatch repair:Sulfur relay system:Sulfur relay system:General function prediction only:General function prediction only:Function unknown:Function unknown:TIGR00003:TIGR00003:3_prime_RNase:3_prime_RNase:mutl:mutl:lpxK:lpxK:yfiA:yfiA:pyrD_sub1_fam:pyrD_sub1_fam:thioredoxin:thioredoxin:cysKM:cysKM:RND_mfp:RND_mfp:type_I_sec_TolC:type_I_sec_TolC:chaperone_ClpB:chaperone_ClpB:FeS_nifS:FeS_nifS:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:DNA metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Protein synthesis:Translation factors:Protein fate:Protein folding and stabilization:Transport and binding proteins:Unknown substrate:Cations and iron carrying compounds:Porins:Amino acid biosynthesis:Serine family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Serine family:Energy metabolism:DNA metabolism:Transcription:Protein synthesis:Protein fate:Transport and binding proteins:Amino acid biosynthesis:Cell envelope:Porins:Cations and iron carrying compounds:Unknown substrate:Protein folding and stabilization:Translation factors:Degradation of RNA:DNA replication, recombination, and repair:Electron transport:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Nucleotide Metabolism:Global:Amino Acid Metabolism:Genetic Information Processing:Metabolism of Other Amino Acids:Metabolism:Glycan Biosynthesis and Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Replication and Repair:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Global:Metabolism:Energy metabolism:Electron transport" 5 "Energy production and conversion:Energy production and conversion:Adenylosuccinate synthase:Adenylosuccinate synthase:Tryptophan synthase beta chain:Tryptophan synthase beta chain:Uncharacterized NAD(FAD)-dependent dehydrogenases:Uncharacterized NAD(FAD)-dependent dehydrogenases:Glycosyltransferases involved in cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:Transcriptional regulator:Transcriptional regulator:2-methylthioadenine synthetase:2-methylthioadenine synthetase:Phosphoglyceromutase:Phosphoglyceromutase:Nitroreductase:Nitroreductase:Uncharacterized homolog of plant Iojap protein:Uncharacterized homolog of plant Iojap protein:Predicted Fe-S-cluster redox enzyme:Predicted Fe-S-cluster redox enzyme:Cation/multidrug efflux pump:Cation/multidrug efflux pump:Membrane-fusion protein:Membrane-fusion protein:GTPase:GTPase:Predicted GTPases:Predicted GTPases:4-diphosphocytidyl-2-methyl-D-erithritol synthase:4-diphosphocytidyl-2-methyl-D-erithritol synthase:Hemolysins and related proteins containing CBS domains:Hemolysins and related proteins containing CBS domains:Transcriptional regulator:Transcriptional regulator:Predicted HD superfamily hydrolase:Predicted HD superfamily hydrolase:Outer membrane protein:Outer membrane protein:Transcriptional regulators:Transcriptional regulators:ABC-type proline/glycine betaine transport system, ATPase component:ABC-type proline/glycine betaine transport system, ATPase component:Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein:Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:sequence-specific DNA binding transcription factor activity:RNA binding:structural constituent of ribosome:catalytic activity:GTPase activity:adenylosuccinate synthase activity:metalloendopeptidase activity:phosphoglycerate mutase activity:tryptophan synthase activity:transporter activity:ATP binding:GTP binding:glucose catabolic process:glycolysis:electron transport:purine nucleotide biosynthetic process:regulation of transcription, DNA-dependent:translation:proteolysis:tryptophan metabolic process:transport:amino acid transport:metabolic process:lipid binding:protein transporter activity:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity:protein secretion:ferrous iron transmembrane transporter activity:amino acid transmembrane transporter activity:quaternary-ammonium-compound-transporting ATPase activity:glycine betaine/proline porter activity:ferrous iron transport:terpenoid biosynthetic process:oxidoreductase activity:specific transcriptional repressor activity:ATPase activity:manganese ion binding:pyridoxal phosphate binding:2-alkenal reductase [NAD(P)] activity:cell redox homeostasis:negative regulation of transcription, DNA-dependent:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity:iron-sulfur cluster binding:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Purine metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:One carbon pool by folate:One carbon pool by folate:Methane metabolism:Methane metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:RNA degradation:RNA degradation:General function prediction only:General function prediction only:Function unknown:Function unknown:TIGR00048:TIGR00048:TIGR00089:TIGR00089:iojap_ybeB:iojap_ybeB:ispF:ispF:purA:purA:small_GTP:small_GTP:trpB:trpB:HDIG:HDIG:2A0602:2A0602:proV:proV:pgm_bpd_ind:pgm_bpd_ind:RND_mfp:RND_mfp:outer_NodT:outer_NodT:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Folding Sorting and Degradation:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Folding Sorting and Degradation:Membrane Transport:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:Glycolysis/gluconeogenesis:Purine ribonucleotide biosynthesis:tRNA and rRNA base modification:Unknown substrate:Amino acids, peptides and amines:Porins:General:Aromatic amino acid family:Other:Energy metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Protein synthesis:Transport and binding proteins:Unknown function:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Unknown substrate:Amino acids, peptides and amines:Porins:Unknown function:General:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 6 "Energy production and conversion:Energy production and conversion:Transaldolase:Transaldolase:ABC-type Co2+ transport system, permease component:ABC-type Co2+ transport system, permease component:Predicted transcriptional regulators:Predicted transcriptional regulators:Fe-S-cluster-containing hydrogenase components 2:Fe-S-cluster-containing hydrogenase components 2:Adenylate cyclase, class 2 (thermophilic):Adenylate cyclase, class 2 (thermophilic):Dihydroxyacetone kinase:Dihydroxyacetone kinase:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:sequence-specific DNA binding transcription factor activity:glycerone kinase activity:membrane-associated guanylate kinase:guanylate kinase activity:sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity:ATP binding:carbohydrate metabolic process:glycerol metabolic process:electron transport:cAMP biosynthetic process:regulation of transcription, DNA-dependent:calcium- and calmodulin-responsive adenylate cyclase activity:formate dehydrogenase (NAD+) activity:pyruvate, water dikinase activity:electron carrier activity:cobalamin biosynthetic process:phosphorylation:iron-sulfur cluster binding:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pentose phosphate pathway:Pentose phosphate pathway:Purine metabolism:Purine metabolism:Glycerolipid metabolism:Glycerolipid metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Function unknown:Function unknown:fsa_talC_mipB:fsa_talC_mipB:dha_L_ycgS:dha_L_ycgS:Pal_lipo:Pal_lipo:Metabolism:Membrane Transport:Environmental Information Processing:Global:Nucleotide Metabolism:Carbohydrate Metabolism:Energy metabolism:Energy metabolism:Pentose phosphate pathway:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Lipid Metabolism:Nucleotide Metabolism:Pentose phosphate pathway:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Lipid Metabolism:Global" 7 "DNA repair exonuclease:DNA repair exonuclease:DNA modification methylase:DNA modification methylase:Sec-independent protein secretion pathway components:Sec-independent protein secretion pathway components:Bacteriophage tail assembly protein:Bacteriophage tail assembly protein:DNA binding:DNA primase activity:iron ion transmembrane transporter activity:DNA replication:DNA methylation:iron ion transport:N-methyltransferase activity:zinc ion binding:protein transporter activity:site-specific DNA-methyltransferase (adenine-specific) activity:protein transport:hydrolase activity:Replication, recombination and repair:Replication, recombination and repair:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:tonB_Cterm:tonB_Cterm:tatAE:tatAE:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Genetic Information Processing:Folding Sorting and Degradation:Information storage and processing:Environmental Information Processing:Membrane Transport:Transport and binding proteins:Protein fate:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Cations and iron carrying compounds:Information storage and processing:Cellular processes and signaling:Poorly characterized:Cations and iron carrying compounds:Protein and peptide secretion and trafficking:Environmental Information Processing:Genetic Information Processing:Membrane Transport:Cellular processes and signaling:Folding Sorting and Degradation:Poorly characterized" 8 "Protein-tyrosine-phosphatase:Protein-tyrosine-phosphatase:Acyl carrier protein phosphodiesterase:Acyl carrier protein phosphodiesterase:AT-rich DNA-binding protein:AT-rich DNA-binding protein:Chloramphenicol O-acetyltransferase:Chloramphenicol O-acetyltransferase:Predicted transcriptional regulator:Predicted transcriptional regulator:DNA binding:protein tyrosine phosphatase activity:electron transport:regulation of transcription, DNA-dependent:protein dephosphorylation:zinc ion binding:arsenate reductase (glutaredoxin) activity:chloramphenicol O-acetyltransferase activity:oxidoreductase activity:transcription repressor activity:negative regulation of transcription, DNA-dependent:coenzyme binding:response to redox state:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:Defense mechanisms:Defense mechanisms:Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Poorly characterized:Poorly characterized:Cellular processes and signaling:Information storage and processing" 9 "Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Tryptophanyl-tRNA synthetase:Tryptophanyl-tRNA synthetase:Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family:Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Biotin synthase and related enzymes:Biotin synthase and related enzymes:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Enoyl-[acyl-carrier-protein] reductase (NADH):Enoyl-[acyl-carrier-protein] reductase (NADH):Predicted permease:Predicted permease:Formyltetrahydrofolate hydrolase:Formyltetrahydrofolate hydrolase:Amino acid permeases:Amino acid permeases:Apolipoprotein N-acyltransferase:Apolipoprotein N-acyltransferase:Uncharacterized membrane protein, required for colicin V production:Uncharacterized membrane protein, required for colicin V production:Zn-dependent proteases:Zn-dependent proteases:Uncharacterized protein conserved in archaea:Uncharacterized protein conserved in archaea:Predicted membrane protein:Predicted membrane protein:Na+/panthothenate symporter:Na+/panthothenate symporter:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:histidine biosynthetic process:catalytic activity:acid phosphatase activity:alkaline phosphatase activity:biotin synthase activity:metalloendopeptidase activity:enoyl-[acyl-carrier-protein] reductase (NADH) activity:enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity:histidinol-phosphate transaminase activity:methenyltetrahydrofolate cyclohydrolase activity:methylenetetrahydrofolate dehydrogenase (NADP+) activity:tryptophan-tRNA ligase activity:transporter activity:ATP binding:'de novo' IMP biosynthetic process:translation:tryptophanyl-tRNA aminoacylation:protein modification process:proteolysis:fatty acid biosynthetic process:nitrogen compound metabolic process:transport:sodium ion transport:amino acid transport:tRNA processing:metabolic process:zinc ion binding:formyltetrahydrofolate deformylase activity:biotin biosynthetic process:cobalamin biosynthetic process:folic acid-containing compound biosynthetic process:toxin biosynthetic process:sodium ion transmembrane transporter activity:amino acid transmembrane transporter activity:pantothenate transmembrane transporter activity:pantothenate transmembrane transport:N-acyltransferase activity:amino acid binding:hydroxymethyl-, formyl- and related transferase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:ligase activity, forming carbon-nitrogen bonds:pyridoxal phosphate binding:sodium ion binding:lipoprotein biosynthetic process:cobyrinic acid a,c-diamide synthase activity:cellular biosynthetic process:S-methyl-5-thioribose-1-phosphate isomerase activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Fatty acid biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Histidine metabolism:Histidine metabolism:Tyrosine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Tryptophan metabolism:Tryptophan metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Novobiocin biosynthesis:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:One carbon pool by folate:Biotin metabolism:Biotin metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Function unknown:Function unknown:trpS:trpS:bioB:bioB:salvage_mtnA:salvage_mtnA:lnt:lnt:PurU:PurU:sss:sss:araaP:araaP:hisC:hisC:lysidine_TilS_N:lysidine_TilS_N:Biotin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation:Biosynthesis of Other Secondary Metabolites:Membrane Transport:Cell Motility:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:Purine ribonucleotide biosynthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein modification and repair:Amino acids, peptides and amines:Cations and iron carrying compounds:Aspartate family:Histidine family:Biotin:Purines, pyrimidines, nucleosides, and nucleotides:Protein synthesis:Protein fate:Transport and binding proteins:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein modification and repair:Transport and binding proteins:Amino acids, peptides and amines:Cations and iron carrying compounds:Amino acid biosynthesis:Aspartate family:Histidine family:Biosynthesis of cofactors, prosthetic groups, and carriers" 10 "Glutamine phosphoribosylpyrophosphate amidotransferase:Glutamine phosphoribosylpyrophosphate amidotransferase:Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain:Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain:Ribosomal protein S12:Ribosomal protein S12:Ribosomal protein S7:Ribosomal protein S7:Histidyl-tRNA synthetase:Histidyl-tRNA synthetase:Transcription elongation factor:Transcription elongation factor:Protein chain release factor A:Protein chain release factor A:Ribosomal protein S18:Ribosomal protein S18:Transcription antiterminator:Transcription antiterminator:3-oxoacyl-[acyl-carrier-protein] synthase III:3-oxoacyl-[acyl-carrier-protein] synthase III:Carbamoylphosphate synthase large subunit (split gene in MJ):Carbamoylphosphate synthase large subunit (split gene in MJ):Phosphoribosylpyrophosphate synthetase:Phosphoribosylpyrophosphate synthetase:Translation elongation factors (GTPases):Translation elongation factors (GTPases):Superfamily II DNA and RNA helicases:Superfamily II DNA and RNA helicases:Translation initiation factor 2 (IF-2; GTPase):Translation initiation factor 2 (IF-2; GTPase):Preprotein translocase subunit YidC:Preprotein translocase subunit YidC:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase):Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase):Predicted membrane GTPase involved in stress response:Predicted membrane GTPase involved in stress response:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted RNA-binding protein:Predicted RNA-binding protein:Deoxycytidylate deaminase:Deoxycytidylate deaminase:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Predicted metal-dependent enzyme:Predicted metal-dependent enzyme:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:nucleotide binding:3'-5'-exoribonuclease activity:magnesium ion binding:nucleic acid binding:sequence-specific DNA binding transcription factor activity:transcription elongation regulator activity:RNA binding:structural constituent of ribosome:translation initiation factor activity:translation elongation factor activity:GTPase activity:amidophosphoribosyltransferase activity:aminoacyl-tRNA hydrolase activity:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity:dCMP deaminase activity:3-oxoacyl-[acyl-carrier-protein] synthase activity:phosphoribosylformylglycinamidine synthase activity:polyribonucleotide nucleotidyltransferase activity:ribose phosphate diphosphokinase activity:histidine-tRNA ligase activity:phenylalanine-tRNA ligase activity:protein binding:ATP binding:GTP binding:'de novo' IMP biosynthetic process:regulation of transcription, DNA-dependent:RNA processing:mRNA catabolic process:translation:translational initiation:translational elongation:translational termination:histidyl-tRNA aminoacylation:phenylalanyl-tRNA aminoacylation:arginine biosynthetic process:fatty acid biosynthetic process:ATP-dependent helicase activity:zinc ion binding:protein-synthesizing GTPase activity:purine base biosynthetic process:nucleoside metabolic process:ribonucleoside monophosphate biosynthetic process:translation release factor activity, codon specific:hydrolase activity:lipoate-protein ligase activity:pyrimidine base biosynthetic process:regulation of transcription termination, DNA-dependent:protein insertion into membrane:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Pentose phosphate pathway:Pentose phosphate pathway:Fatty acid biosynthesis:Fatty acid biosynthesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Ribosome:Ribosome:RNA degradation:RNA degradation:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:prfA:prfA:S18:S18:small_GTP:small_GTP:hisS:hisS:fabH:fabH:nusG:nusG:rpsL_bact:rpsL_bact:rpsG_bact:rpsG_bact:purF:purF:ribP_PPkin:ribP_PPkin:CPSaseII_lrg:CPSaseII_lrg:NusA:NusA:polynuc_phos:polynuc_phos:yidC_oxa1_cterm:yidC_oxa1_cterm:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:Transcription:Degradation of RNA:Transcription factors:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Unknown function:Protein fate:Protein synthesis:Transcription:Purines, pyrimidines, nucleosides, and nucleotides:Fatty acid and phospholipid metabolism:General:Protein and peptide secretion and trafficking:Translation factors:Ribosomal proteins: synthesis and modification:tRNA aminoacylation:Transcription factors:Degradation of RNA:Pyrimidine ribonucleotide biosynthesis:Purine ribonucleotide biosynthesis:Biosynthesis:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Membrane Transport:Translation:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Folding Sorting and Degradation:Global:Metabolism:Environmental Information Processing:Folding Sorting and Degradation:Translation:Genetic Information Processing:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism" 11 "Energy production and conversion:Energy production and conversion:Polyprenyltransferase (cytochrome oxidase assembly factor):Polyprenyltransferase (cytochrome oxidase assembly factor):Signal transduction histidine kinase:Signal transduction histidine kinase:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Heme/copper-type cytochrome/quinol oxidases, subunit 2:Heme/copper-type cytochrome/quinol oxidases, subunit 2:Type II secretory pathway, prepilin signal peptidase PulO and related peptidases:Type II secretory pathway, prepilin signal peptidase PulO and related peptidases:Uncharacterized conserved protein:Uncharacterized conserved protein:Flp pilus assembly protein, protease CpaA:Flp pilus assembly protein, protease CpaA:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:cytochrome-c oxidase activity:dihydropteroate synthase activity:hydrolase activity, hydrolyzing O-glycosyl compounds:signal transducer activity:transporter activity:iron ion binding:copper ion binding:ATP binding:carbohydrate metabolic process:electron transport:regulation of transcription, DNA-dependent:heme biosynthetic process:transport:chemotaxis:signal transduction:protoheme IX farnesyltransferase activity:prepilin peptidase activity:electron carrier activity:folic acid-containing compound biosynthetic process:aa3-type cytochrome c oxidase:ba3-type cytochrome c oxidase:caa3-type cytochrome c oxidase:cbb3-type cytochrome c oxidase:peptidyl-histidine phosphorylation:heme binding:metal ion binding:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Oxidative phosphorylation:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:hemeryth_dom:hemeryth_dom:CoxB:CoxB:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins:Energy Metabolism:Metabolism:Energy metabolism:Environmental Information Processing:Cellular Processes:Global:Electron transport:Small molecule interactions:Energy metabolism:Regulatory functions:Cell Motility:Signal Transduction:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Metabolism:Electron transport:Regulatory functions:Small molecule interactions" 12 "3,4-dihydroxy-2-butanone 4-phosphate synthase:3,4-dihydroxy-2-butanone 4-phosphate synthase:Glycosyltransferase:Glycosyltransferase:Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family:Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family:Helicase subunit of the DNA excision repair complex:Helicase subunit of the DNA excision repair complex:Predicted exonuclease of the beta-lactamase fold involved in RNA processing:Predicted exonuclease of the beta-lactamase fold involved in RNA processing:Methionine synthase I, cobalamin-binding domain:Methionine synthase I, cobalamin-binding domain:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:NCAIR mutase (PurE)-related proteins:NCAIR mutase (PurE)-related proteins:Phosphate starvation-inducible protein PhoH, predicted ATPase:Phosphate starvation-inducible protein PhoH, predicted ATPase:Uncharacterized conserved protein:Uncharacterized conserved protein:ABC-type transport system involved in cytochrome c biogenesis, permease component:ABC-type transport system involved in cytochrome c biogenesis, permease component:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Nucleoside 2-deoxyribosyltransferase:Nucleoside 2-deoxyribosyltransferase:ATP-dependent protease HslVU (ClpYQ), peptidase subunit:ATP-dependent protease HslVU (ClpYQ), peptidase subunit:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:sequence-specific DNA binding transcription factor activity:GTP cyclohydrolase II activity:aspartate kinase activity:dihydropteroate synthase activity:threonine-type endopeptidase activity:helicase activity:phosphoribosylaminoimidazole carboxylase activity:ATP binding:'de novo' IMP biosynthetic process:nucleotide-excision repair:regulation of transcription, DNA-dependent:ubiquitin-dependent protein catabolic process:signal transduction:transcription factor binding:3,4-dihydroxy-2-butanone-4-phosphate synthase activity:methionine synthase activity:homocysteine S-methyltransferase activity:inositol monophosphate phosphatase activity:biosynthetic process:methionine biosynthetic process:riboflavin biosynthetic process:excinuclease ABC activity:folic acid-containing compound biosynthetic process:heme transporter activity:heme transport:cellular response to phosphate starvation:hydrolase activity:cytochrome complex assembly:nucleoside-triphosphatase activity:cobalamin binding:metal ion binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Inositol phosphate metabolism:Inositol phosphate metabolism:One carbon pool by folate:One carbon pool by folate:Riboflavin metabolism:Riboflavin metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Nucleotide excision repair:Nucleotide excision repair:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:ribB:ribB:uvrb:uvrb:MJ0042_CXXC:MJ0042_CXXC:ATP_dep_HslV:ATP_dep_HslV:Carbohydrate Metabolism:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Degradation of proteins, peptides, and glycopeptides:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Poorly characterized:Metabolism:Cellular processes and signaling:Carbohydrate Metabolism:Information storage and processing:Biosynthesis of cofactors, prosthetic groups, and carriers:Protein fate:DNA metabolism:Riboflavin, FMN, and FAD:Degradation of proteins, peptides, and glycopeptides:DNA replication, recombination, and repair:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Replication and Repair:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Replication and Repair:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Amino Acid Metabolism:Global:Metabolism" 13 "Glutamate synthase domain 1:Glutamate synthase domain 1:Glutamate synthase domain 2:Glutamate synthase domain 2:Glutamate synthase domain 3:Glutamate synthase domain 3:Molybdopterin biosynthesis enzyme:Molybdopterin biosynthesis enzyme:Nucleotide-binding protein implicated in inhibition of septum formation:Nucleotide-binding protein implicated in inhibition of septum formation:Acetylglutamate kinase:Acetylglutamate kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Phage shock protein A (IM30), suppresses sigma54-dependent transcription:Phage shock protein A (IM30), suppresses sigma54-dependent transcription:Putative stress-responsive transcriptional regulator:Putative stress-responsive transcriptional regulator:K+-transporting ATPase, A chain:K+-transporting ATPase, A chain:K+-transporting ATPase, c chain:K+-transporting ATPase, c chain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:High-affinity K+ transport system, ATPase chain B:High-affinity K+ transport system, ATPase chain B:Leucyl aminopeptidase (aminopeptidase T):Leucyl aminopeptidase (aminopeptidase T):Predicted membrane protein:Predicted membrane protein:Plasmid maintenance system killer protein:Plasmid maintenance system killer protein:Flp pilus assembly protein, pilin Flp:Flp pilus assembly protein, pilin Flp:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:acetylglutamate kinase activity:aminopeptidase activity:glutamate synthase (NADPH) activity:calcium ion binding:ATP binding:electron transport:regulation of transcription, DNA-dependent:proteolysis:arginine biosynthetic process:glutamate biosynthetic process:Mo-molybdopterin cofactor biosynthetic process:potassium ion transport:signal transduction:transcription factor binding:metabolic process:potassium-transporting ATPase activity:electron carrier activity:glutamate synthase (NADH) activity:nucleoside-triphosphatase activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Lysine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:maf:maf:kdpA:kdpA:kdpC:kdpC:argB:argB:ATPase_P-type:ATPase_P-type:phageshock_pspF:phageshock_pspF:phageshock_pspB:phageshock_pspB:phageshock_pspA:phageshock_pspA:phageshock_pspC:phageshock_pspC:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Transport and binding proteins:Cellular processes:Amino acid biosynthesis:Adaptations to atypical conditions:Cell division:Cations and iron carrying compounds:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Environmental Information Processing:Signal Transduction:Global:Metabolism:Regulatory functions:DNA interactions:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Cell division:Adaptations to atypical conditions:Amino acid biosynthesis:Glutamate family:Information storage and processing:Regulatory functions:Metabolism:Poorly characterized:DNA interactions:Global:Environmental Information Processing:Metabolism:Metabolism:Signal Transduction:Amino Acid Metabolism:Glutamate family" 14 "Energy production and conversion:Energy production and conversion:Fumarase:Fumarase:Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain:Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain:Glycosyltransferase:Glycosyltransferase:Glycosyltransferases involved in cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:Carbamoylphosphate synthase small subunit:Carbamoylphosphate synthase small subunit:Glycerol-3-phosphate dehydrogenase:Glycerol-3-phosphate dehydrogenase:Permeases of the drug/metabolite transporter (DMT) superfamily:Permeases of the drug/metabolite transporter (DMT) superfamily:Adenine deaminase:Adenine deaminase:Aconitase A:Aconitase A:Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Uncharacterized conserved protein:Uncharacterized conserved protein:Metal-dependent amidase/aminoacylase/carboxypeptidase:Metal-dependent amidase/aminoacylase/carboxypeptidase:D-Tyr-tRNAtyr deacylase:D-Tyr-tRNAtyr deacylase:Cytochrome c-type biogenesis protein CcmE:Cytochrome c-type biogenesis protein CcmE:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Paraquat-inducible protein B:Paraquat-inducible protein B:Uncharacterized protein conserved in archaea:Uncharacterized protein conserved in archaea:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:ABC-type uncharacterized transport system, periplasmic component:ABC-type uncharacterized transport system, periplasmic component:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:adenine deaminase activity:two-component sensor activity:two-component signal transduction system (phosphorelay):aconitate hydratase activity:aminoacyl-tRNA hydrolase activity:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity:dihydrolipoyl dehydrogenase activity:fumarate hydratase activity:glycerol-3-phosphate dehydrogenase activity:glycine cleavage system:glycine dehydrogenase (decarboxylating) activity:protein serine/threonine phosphatase activity:calcium-dependent protein serine/threonine phosphatase activity:magnesium-dependent protein serine/threonine phosphatase activity:transporter activity:sugar:hydrogen symporter activity:ATP binding:glycerol-3-phosphate metabolic process:tricarboxylic acid cycle:fumarate metabolic process:electron transport:adenine catabolic process:regulation of transcription, DNA-dependent:aminoacyl-tRNA hydrolase reaction:proteolysis:glutamine metabolic process:glycine metabolic process:nitrogen compound metabolic process:transport:signal transduction:metallopeptidase activity:CTD phosphatase activity:calcium-dependent protein serine/threonine phosphatase regulator activity:cellular amino acid biosynthetic process:biosynthetic process:phosphoenolpyruvate-dependent sugar phosphotransferase system:oxidoreductase activity:hydrolase activity:hydrolase activity, acting on ester bonds:antibiotic biosynthetic process:cytochrome complex assembly:myosin phosphatase activity:myosin phosphatase regulator activity:peptidyl-histidine phosphorylation:D-amino acid catabolic process:pyridoxal phosphate binding:cell redox homeostasis:protein dimerization activity:glucose-1-phosphate cytidylyltransferase activity:hippurate hydrolase activity:flavin adenine dinucleotide binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine degradation:Arginine and proline metabolism:Arginine and proline metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Pyruvate metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:TIGR00256:TIGR00256:fumC_II:fumC_II:ade:ade:acon_putative:acon_putative:CPSaseIIsmall:CPSaseIIsmall:amidohydrolases:amidohydrolases:G1P_cyt_trans:G1P_cyt_trans:Poorly characterized:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Degradation of proteins, peptides, and glycopeptides:tRNA aminoacylation:Small molecule interactions:Salvage of nucleosides and nucleotides:Pyrimidine ribonucleotide biosynthesis:TCA cycle:Global:Metabolism:Metabolism:Amino Acid Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Lipid Metabolism:Poorly characterized:Metabolism:Metabolism:Carbohydrate Metabolism:Cellular processes and signaling:Information storage and processing:Lipid Metabolism:Nucleotide Metabolism:Cell envelope:Protein fate:Amino Acid Metabolism:Protein synthesis:Regulatory functions:Purines, pyrimidines, nucleosides, and nucleotides:Energy metabolism:Global:Metabolism:Energy metabolism:TCA cycle:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Salvage of nucleosides and nucleotides:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA aminoacylation:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism" 15 "Imidazoleglycerol-phosphate synthase:Imidazoleglycerol-phosphate synthase:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:Signal transduction histidine kinase:Signal transduction histidine kinase:UDP-N-acetylmuramate dehydrogenase:UDP-N-acetylmuramate dehydrogenase:Predicted glycosyltransferases:Predicted glycosyltransferases:Putative multicopper oxidases:Putative multicopper oxidases:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Nitrate/nitrite transporter:Nitrate/nitrite transporter:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:histidine biosynthetic process:imidazoleglycerol-phosphate synthase activity:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:DNA-directed DNA polymerase activity:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity:signal transducer activity:transporter activity:copper ion binding:ATP binding:malate metabolic process:DNA repair:regulation of transcription, DNA-dependent:RNA processing:transport:signal transduction:tRNA processing:transcription factor binding:UDP-N-acetylmuramate dehydrogenase activity:cyclic nucleotide biosynthetic process:peptidoglycan biosynthetic process:oxidoreductase activity:malate dehydrogenase activity:phosphorus-oxygen lyase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:intracellular signal transduction:flavin adenine dinucleotide binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Histidine metabolism:Histidine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Sulfur relay system:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:murB:murB:GGDEF:GGDEF:trmU:trmU:hisF:hisF:Amino acid biosynthesis:Histidine family:Signal transduction:Other:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Signal Transduction:Folding Sorting and Degradation:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Carbohydrate Metabolism:Protein synthesis:Biosynthesis and degradation of murein sacculus and peptidoglycan:Amino acid biosynthesis:Signal transduction:Cell envelope:Other:Histidine family:tRNA and rRNA base modification:Global:Environmental Information Processing:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Genetic Information Processing:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Protein synthesis:tRNA and rRNA base modification" 16 "Energy production and conversion:Energy production and conversion:Diaminopimelate decarboxylase:Diaminopimelate decarboxylase:Protein chain release factor A:Protein chain release factor A:Mismatch repair ATPase (MutS family):Mismatch repair ATPase (MutS family):Diaminopimelate epimerase:Diaminopimelate epimerase:Aspartate/tyrosine/aromatic aminotransferase:Aspartate/tyrosine/aromatic aminotransferase:Glycosyltransferase:Glycosyltransferase:Protease subunit of ATP-dependent Clp proteases:Protease subunit of ATP-dependent Clp proteases:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase:Predicted Zn-dependent peptidases, insulinase-like:Predicted Zn-dependent peptidases, insulinase-like:Transcriptional regulators, similar to M. xanthus CarD:Transcriptional regulators, similar to M. xanthus CarD:Flagellar motor protein:Flagellar motor protein:D-alanyl-D-alanine carboxypeptidase:D-alanyl-D-alanine carboxypeptidase:Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family:Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family:AT-rich DNA-binding protein:AT-rich DNA-binding protein:Predicted transcriptional regulator with C-terminal CBS domains:Predicted transcriptional regulator with C-terminal CBS domains:ACT domain-containing protein:ACT domain-containing protein:Amino acid transport and metabolism:Amino acid transport and metabolism:damaged DNA binding:sequence-specific DNA binding transcription factor activity:structural constituent of ribosome:catalytic activity:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity:GTPase activity:acetolactate synthase activity:aminoacyl-tRNA hydrolase activity:metalloendopeptidase activity:transporter activity:ATP binding:mismatch repair:regulation of transcription, DNA-dependent:translation:translational termination:proteolysis:transport:metabolic process:zinc ion binding:endopeptidase Clp activity:protein-synthesizing GTPase activity:diaminopimelate decarboxylase activity:diaminopimelate epimerase activity:serine-type D-Ala-D-Ala carboxypeptidase activity:biosynthetic process:lysine biosynthetic process via diaminopimelate:folic acid-containing compound biosynthetic process:L,L-diaminopimelate aminotransferase activity:translation release factor activity, codon specific:oxidoreductase activity:transcription repressor activity:amino acid binding:transferase activity, transferring nitrogenous groups:pyridoxal phosphate binding:mismatched DNA binding:negative regulation of transcription, DNA-dependent:metal ion binding:response to redox state:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Lysine biosynthesis:Lysine biosynthesis:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Folate biosynthesis:Folate biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Mismatch repair:Mismatch repair:General function prediction only:General function prediction only:prfB:prfB:rlpA:rlpA:clpP:clpP:DapF:DapF:lysA:lysA:mutS1:mutS1:folK:folK:DapC_direct:DapC_direct:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Other:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Translation factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Cell envelope:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Cell Motility:Replication and Repair:Information storage and processing:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Cellular Processes:Folic acid:Global:DNA replication, recombination, and repair:Translation factors:Degradation of proteins, peptides, and glycopeptides:Aspartate family:Cell envelope:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino acid biosynthesis:Protein fate:Protein synthesis:DNA metabolism:Cellular Processes:Cell Motility:Replication and Repair:Global:Metabolism:Genetic Information Processing:Metabolism of Cofactors and Vitamins" 17 "Energy production and conversion:Energy production and conversion:Purine nucleoside phosphorylase:Purine nucleoside phosphorylase:Triosephosphate isomerase:Triosephosphate isomerase:Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases:Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases:Peroxiredoxin:Peroxiredoxin:Molybdopterin biosynthesis enzymes:Molybdopterin biosynthesis enzymes:Transcriptional regulator:Transcriptional regulator:Fe2+/Zn2+ uptake regulation proteins:Fe2+/Zn2+ uptake regulation proteins:Phosphomannomutase:Phosphomannomutase:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Cytochrome bd-type quinol oxidase, subunit 1:Cytochrome bd-type quinol oxidase, subunit 1:Cytochrome bd-type quinol oxidase, subunit 2:Cytochrome bd-type quinol oxidase, subunit 2:Predicted alternative 3-dehydroquinate synthase:Predicted alternative 3-dehydroquinate synthase:Beta-glucosidase-related glycosidases:Beta-glucosidase-related glycosidases:Rubrerythrin:Rubrerythrin:Predicted signal transduction protein:Predicted signal transduction protein:Rubredoxin:Rubredoxin:DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes:DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes:Pyridoxal phosphate biosynthesis protein:Pyridoxal phosphate biosynthesis protein:Transcriptional accessory protein:Transcriptional accessory protein:Predicted membrane protein:Predicted membrane protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Molybdopterin-binding protein:Molybdopterin-binding protein:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:double-stranded RNA adenosine deaminase activity:catalytic activity:3-deoxy-7-phosphoheptulonate synthase activity:3-dehydroquinate synthase activity:fructose-bisphosphate aldolase activity:phosphomannomutase activity:phosphopyruvate hydratase activity:polyribonucleotide nucleotidyltransferase activity:purine-nucleoside phosphorylase activity:triose-phosphate isomerase activity:ATP binding:carbohydrate metabolic process:glycolysis:electron transport:nucleobase-containing compound metabolic process:DNA recombination:regulation of transcription, DNA-dependent:Mo-molybdopterin cofactor biosynthetic process:transport:4-alpha-hydroxytetrahydrobiopterin dehydratase activity:transcription factor binding:metabolic process:zinc ion binding:cation transmembrane transporter activity:pyridoxine biosynthetic process:L-fuculose-phosphate aldolase activity:electron carrier activity:nucleoside metabolic process:nucleotide metabolic process:DNA integration:molybdate transmembrane-transporting ATPase activity:nickel-transporting ATPase activity:beta-N-acetylglucosaminidase activity:oxidoreductase activity:hydrolase activity:hydrolase activity, acting on ester bonds:nucleoside-triphosphatase activity:molybdenum ion binding:metal ion binding:transition metal ion binding:glycolaldehyde dehydrogenase activity:4-hydroxythreonine-4-phosphate dehydrogenase activity:NAD binding:peroxiredoxin activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Fructose and mannose metabolism:Fructose and mannose metabolism:Oxidative phosphorylation:Oxidative phosphorylation:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Inositol phosphate metabolism:Inositol phosphate metabolism:Vitamin B6 metabolism:Vitamin B6 metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:YaeB_AF0241:YaeB_AF0241:molyb_syn:molyb_syn:cydB:cydB:HDIG:HDIG:tim:tim:pdxA:pdxA:Mop:Mop:PNPH-PUNA-XAPA:PNPH-PUNA-XAPA:AroFGH_arch:AroFGH_arch:argP:argP:Unknown function:Transport and binding proteins:Regulatory functions:Energy metabolism:Pyridoxine:Enzymes of unknown specificity:Anions:DNA interactions:Glycolysis/gluconeogenesis:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Electron transport:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Glycolysis/gluconeogenesis:Regulatory functions:DNA interactions:Transport and binding proteins:Anions:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridoxine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Global:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Energy Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers" 18 "Energy production and conversion:Energy production and conversion:GTPases - translation elongation factors:GTPases - translation elongation factors:Ribosomal protein S10:Ribosomal protein S10:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:Ribosomal protein L27:Ribosomal protein L27:Ribosomal protein S16:Ribosomal protein S16:Ribosomal protein L21:Ribosomal protein L21:Ribosomal protein L19:Ribosomal protein L19:Threonyl-tRNA synthetase:Threonyl-tRNA synthetase:FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor):FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor):Single-stranded DNA-binding protein:Single-stranded DNA-binding protein:RimM protein, required for 16S rRNA processing:RimM protein, required for 16S rRNA processing:Ferredoxin:Ferredoxin:Preprotein translocase subunit SecG:Preprotein translocase subunit SecG:Uncharacterized protein (competence- and mitomycin-induced):Uncharacterized protein (competence- and mitomycin-induced):Predicted RNA-binding protein (contains KH domain):Predicted RNA-binding protein (contains KH domain):Transposase and inactivated derivatives:Transposase and inactivated derivatives:nucleotide binding:nucleic acid binding:DNA binding:single-stranded DNA binding:RNA binding:structural constituent of ribosome:translation elongation factor activity:peptidyl-prolyl cis-trans isomerase activity:DNA topoisomerase (ATP-hydrolyzing) activity:GTPase activity:ribonuclease P activity:cyclophilin:threonine-tRNA ligase activity:ATP binding:GTP binding:electron transport:DNA replication:DNA topological change:DNA unwinding involved in replication:rRNA processing:translation:translational elongation:threonyl-tRNA aminoacylation:protein folding:protein-synthesizing GTPase activity:agmatinase activity:electron carrier activity:protein secretion:protein transport:DNA integration:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:FK506-sensitive peptidyl-prolyl cis-trans isomerase:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:ribosome binding:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Ribosome:Ribosome:DNA replication:DNA replication:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:S16:S16:S21p:S21p:L21:L21:L27:L27:tig:tig:cinA_cterm:cinA_cterm:small_GTP:small_GTP:thrS:thrS:ssb:ssb:secG:secG:rplS_bact:rplS_bact:rpmH_bact:rpmH_bact:rpsJ_bact:rpsJ_bact:gyrA:gyrA:16S_RimM:16S_RimM:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Environmental Information Processing:RNA processing:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Protein folding and stabilization:Protein and peptide secretion and trafficking:General:DNA metabolism:Transcription:Protein synthesis:Protein fate:Unknown function:Genetic Information Processing:Membrane Transport:Replication and Repair:Folding Sorting and Degradation:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Genetic Information Processing:Translation:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:DNA metabolism:DNA replication, recombination, and repair:Transcription:RNA processing:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Protein fate:Protein folding and stabilization:Protein and peptide secretion and trafficking:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:DNA replication, recombination, and repair" 19 "Superfamily II DNA and RNA helicases:Superfamily II DNA and RNA helicases:Signal transduction histidine kinase:Signal transduction histidine kinase:Shikimate kinase:Shikimate kinase:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Cobalamin biosynthesis protein CbiG:Cobalamin biosynthesis protein CbiG:Predicted phosphoesterases, related to the Icc protein:Predicted phosphoesterases, related to the Icc protein:Predicted membrane protein:Predicted membrane protein:ABC-type uncharacterized transport system, auxiliary component:ABC-type uncharacterized transport system, auxiliary component:Site-specific recombinase XerD:Site-specific recombinase XerD:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:catalytic activity:shikimate kinase activity:signal transducer activity:sugar:hydrogen symporter activity:ATP binding:DNA recombination:regulation of transcription, DNA-dependent:cellular amino acid metabolic process:chemotaxis:signal transduction:ATP-dependent helicase activity:metabolic process:cobalamin biosynthetic process:nitrogen fixation:phosphoenolpyruvate-dependent sugar phosphotransferase system:DNA integration:nitrogenase activity:oxidoreductase activity:hydrolase activity:peptidyl-histidine phosphorylation:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:RNA degradation:RNA degradation:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Cell Motility:Signal Transduction:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Small molecule interactions:Regulatory functions:Global:Cellular Processes:Environmental Information Processing:Genetic Information Processing:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:Small molecule interactions" 20 "Putative translation initiation inhibitor, yjgF family:Putative translation initiation inhibitor, yjgF family:HrpA-like helicases:HrpA-like helicases:1-aminocyclopropane-1-carboxylate deaminase:1-aminocyclopropane-1-carboxylate deaminase:Uncharacterized homolog of phage Mu protein gp47:Uncharacterized homolog of phage Mu protein gp47:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Mu-like prophage DNA circulation protein:Mu-like prophage DNA circulation protein:Mu-like prophage tail protein gpP:Mu-like prophage tail protein gpP:Mu-like prophage protein gp46:Mu-like prophage protein gp46:Mu-like prophage protein gp45:Mu-like prophage protein gp45:Amino acid transport and metabolism:Amino acid transport and metabolism:nucleic acid binding:helicase activity:ATP binding:DNA packaging:metabolic process:1-aminocyclopropane-1-carboxylate deaminase activity:phosphorylation:transferase activity, transferring phosphorus-containing groups:D-cysteine desulfhydrase activity:pyridoxal phosphate binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cysteine and methionine metabolism:Cysteine and methionine metabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:TIGR00004:TIGR00004:ACC_deam_rel:ACC_deam_rel:phage_P2_V:phage_P2_V:DEAH_box_HrpB:DEAH_box_HrpB:Poorly characterized:Transcription:Enzymes of unknown specificity:Prophage functions:Degradation of RNA:Metabolism:Amino Acid Metabolism:Mobile and extrachromosomal element functions:Unknown function:Information storage and processing:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Transcription:Degradation of RNA:Mobile and extrachromosomal element functions:Prophage functions:Unknown function:Enzymes of unknown specificity:Information storage and processing:Metabolism" 21 "Integrase:Integrase:Membrane-bound lytic murein transglycosylase:Membrane-bound lytic murein transglycosylase:Mu-like prophage FluMu protein gp28:Mu-like prophage FluMu protein gp28:DNA binding:hydrolase activity, hydrolyzing O-glycosyl compounds:DNA recombination:peptidoglycan turnover:DNA integration:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:General function prediction only:General function prediction only:tape_meas_nterm:tape_meas_nterm:Poorly characterized:Cellular processes and signaling:Information storage and processing:Poorly characterized:Cellular processes and signaling:Information storage and processing" 22 "Asparagine synthase (glutamine-hydrolyzing):Asparagine synthase (glutamine-hydrolyzing):Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Hydrogenase maturation factor:Hydrogenase maturation factor:Transcriptional regulator:Transcriptional regulator:Flagellar biosynthesis pathway, component FlhA:Flagellar biosynthesis pathway, component FlhA:Flagellin and related hook-associated proteins:Flagellin and related hook-associated proteins:Flagellar capping protein:Flagellar capping protein:Flagellin-specific chaperone FliS:Flagellin-specific chaperone FliS:Flagellar hook protein FlgE:Flagellar hook protein FlgE:Flagellar hook capping protein:Flagellar hook capping protein:Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog:Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog:Flagellar biosynthesis pathway, component FliQ:Flagellar biosynthesis pathway, component FliQ:FOG: GGDEF domain:FOG: GGDEF domain:Tfp pilus assembly protein PilF:Tfp pilus assembly protein PilF:Amino acid transport and metabolism:Amino acid transport and metabolism:ciliary or flagellar motility:sequence-specific DNA binding transcription factor activity:motor activity:catalytic activity:asparagine synthase (glutamine-hydrolyzing) activity:structural molecule activity:binding:regulation of transcription, DNA-dependent:asparagine biosynthetic process:cell adhesion:metabolic process:methyltransferase activity:lipopolysaccharide biosynthetic process:cyclic nucleotide biosynthetic process:flagellum assembly:protein secretion:oligosaccharide biosynthetic process:nodulation:protein transport:phosphorus-oxygen lyase activity:pyridoxal phosphate binding:intracellular signal transduction:metal ion binding:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Flagellar assembly:Flagellar assembly:Signal transduction mechanisms:Signal transduction mechanisms:hypD:hypD:fliS:fliS:GGDEF:GGDEF:FlhA:FlhA:fliQ:fliQ:asn_synth_AEB:asn_synth_AEB:flagell_flgL:flagell_flgL:FlgEFG_subfam:FlgEFG_subfam:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Metabolism:Metabolism:Metabolism:Cell Motility:Signal Transduction:Amino Acid Metabolism:Energy Metabolism:Aspartate family:Other:Protein fate:Cellular processes:Amino acid biosynthesis:Signal transduction:Chemotaxis and motility:Protein modification and repair:Global:Cellular Processes:Environmental Information Processing:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Energy Metabolism:Amino Acid Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Protein fate:Protein modification and repair:Cellular processes:Chemotaxis and motility:Amino acid biosynthesis:Aspartate family:Signal transduction:Other:Information storage and processing" 23 "Glutamate-1-semialdehyde aminotransferase:Glutamate-1-semialdehyde aminotransferase:Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Isoleucyl-tRNA synthetase:Isoleucyl-tRNA synthetase:Xanthosine triphosphate pyrophosphatase:Xanthosine triphosphate pyrophosphatase:5-enolpyruvylshikimate-3-phosphate synthase:5-enolpyruvylshikimate-3-phosphate synthase:Imidazoleglycerol-phosphate dehydratase:Imidazoleglycerol-phosphate dehydratase:Predicted EndoIII-related endonuclease:Predicted EndoIII-related endonuclease:Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family:Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family:Recombinational DNA repair protein (RecF pathway):Recombinational DNA repair protein (RecF pathway):ATPase involved in DNA repair:ATPase involved in DNA repair:Sugar kinases, ribokinase family:Sugar kinases, ribokinase family:ABC-type Fe3+-siderophore transport system, permease component:ABC-type Fe3+-siderophore transport system, permease component:ABC-type Fe3+-hydroxamate transport system, periplasmic component:ABC-type Fe3+-hydroxamate transport system, periplasmic component:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Precorrin-2 methylase:Precorrin-2 methylase:DNA polymerase III, gamma/tau subunits:DNA polymerase III, gamma/tau subunits:Predicted exonuclease:Predicted exonuclease:ABC-type sugar transport systems, ATPase components:ABC-type sugar transport systems, ATPase components:UDP-glucose pyrophosphorylase:UDP-glucose pyrophosphorylase:Cobalamin biosynthesis protein CbiK, Co2+ chelatase:Cobalamin biosynthesis protein CbiK, Co2+ chelatase:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:histidine biosynthetic process:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:DNA-directed DNA polymerase activity:DNA-(apurinic or apyrimidinic site) lyase activity:UTP:glucose-1-phosphate uridylyltransferase activity:adenosine kinase activity:imidazoleglycerol-phosphate dehydratase activity:endonuclease activity:phosphoribosylaminoimidazole carboxylase activity:isoleucine-tRNA ligase activity:transporter activity:iron ion transmembrane transporter activity:binding:ATP binding:'de novo' IMP biosynthetic process:DNA metabolic process:DNA replication:DNA repair:base-excision repair:DNA recombination:regulation of transcription, DNA-dependent:isoleucyl-tRNA aminoacylation:transport:high-affinity iron ion transport:transcription factor binding:NADH dehydrogenase (ubiquinone) activity:metabolic process:zinc ion binding:transaminase activity:cobalamin biosynthetic process:four-way junction helicase activity:glycerol-3-phosphate-transporting ATPase activity:iron-chelate-transporting ATPase activity:transferase activity, transferring alkyl or aryl (other than methyl) groups:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances:sirohydrochlorin cobaltochelatase activity:ATPase activity:nucleoside-triphosphatase activity:pyridoxal phosphate binding:precorrin-2 C20-methyltransferase activity:tetrapyrrole biosynthetic process:glutamate-1-semialdehyde 2,1-aminomutase activity:cobalt-factor II C20-methyltransferase activity:cellular biosynthetic process:S-methyl-5-thioribose-1-phosphate isomerase activity:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Pentose and glucuronate interconversions:Galactose metabolism:Galactose metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Histidine metabolism:Histidine metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Thiamine metabolism:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:DNA replication:DNA replication:Base excision repair:Base excision repair:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00042:TIGR00042:DNA_YbaB_EbfC:DNA_YbaB_EbfC:ileS:ileS:salvage_mtnA:salvage_mtnA:recR:recR:hemL:hemL:nth:nth:purE:purE:cobI_cbiL:cobI_cbiL:dnaX_nterm:dnaX_nterm:tol_pal_ybgF:tol_pal_ybgF:DNA replication, recombination, and repair:Global:Purine ribonucleotide biosynthesis:DNA replication, recombination, and repair:tRNA aminoacylation:General:Aspartate family:Heme, porphyrin, and cobalamin:Purines, pyrimidines, nucleosides, and nucleotides:DNA metabolism:Protein synthesis:Unknown function:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Replication and Repair:Translation:Metabolism of Cofactors and Vitamins:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:DNA metabolism:Environmental Information Processing:Protein synthesis:tRNA aminoacylation:Unknown function:General:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Carbohydrate Metabolism" 24 "Mu-like prophage protein gp29:Mu-like prophage protein gp29:Mu-like prophage protein gpG:Mu-like prophage protein gpG:nucleotide binding:General function prediction only:General function prediction only:Function unknown:Function unknown:tail_comp_S:tail_comp_S:Prophage functions:Poorly characterized:Mobile and extrachromosomal element functions:Poorly characterized:Mobile and extrachromosomal element functions:Prophage functions" 25 "Energy production and conversion:Energy production and conversion:Thioredoxin reductase:Thioredoxin reductase:Integrase:Integrase:Transcriptional regulator:Transcriptional regulator:Endonuclease IV:Endonuclease IV:DNA polymerase I - 3'-5' exonuclease and polymerase domains:DNA polymerase I - 3'-5' exonuclease and polymerase domains:Diacylglycerol kinase:Diacylglycerol kinase:Precorrin-3B methylase:Precorrin-3B methylase:NAD(FAD)-utilizing enzyme possibly involved in translation:NAD(FAD)-utilizing enzyme possibly involved in translation:CMP-2-keto-3-deoxyoctulosonic acid synthetase:CMP-2-keto-3-deoxyoctulosonic acid synthetase:Recombinational DNA repair protein (RecF pathway):Recombinational DNA repair protein (RecF pathway):Cobyric acid synthase:Cobyric acid synthase:Pyruvate-formate lyase:Pyruvate-formate lyase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Site-specific recombinase XerD:Site-specific recombinase XerD:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA-directed DNA polymerase activity:diacylglycerol kinase activity:thioredoxin-disulfide reductase activity:carbohydrate metabolic process:glucose metabolic process:electron transport:DNA replication:DNA repair:DNA recombination:regulation of transcription, DNA-dependent:tRNA processing:5'-3' exonuclease activity:phospholipid biosynthetic process:3-deoxy-manno-octulosonate cytidylyltransferase activity:deoxyribonuclease IV (phage-T4-induced) activity:formate C-acetyltransferase activity:biosynthetic process:lipopolysaccharide biosynthetic process:cyclic nucleotide biosynthetic process:cobalamin biosynthetic process:protein secretion:pathogenesis:disulfide oxidoreductase activity:DNA integration:type III protein (virulence-related) secretor activity:phosphotransferase activity, alcohol group as acceptor:nucleotidyltransferase activity:phosphorus-oxygen lyase activity:molybdenum ion binding:pyridoxal phosphate binding:protein secretion by the type III secretion system:precorrin-3B C17-methyltransferase activity:intracellular signal transduction:cobyrinic acid a,c-diamide synthase activity:regulation of GTPase activity:flavin adenine dinucleotide binding:negative regulation of protein secretion:adenosylcobyric acid synthase (glutamine-hydrolyzing) activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Glycerolipid metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Butanoate metabolism:Butanoate metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:DNA replication:DNA replication:Bacterial secretion system:Bacterial secretion system:Base excision repair:Base excision repair:Nucleotide excision repair:Nucleotide excision repair:Homologous recombination:Homologous recombination:Function unknown:Function unknown:cyt_tran_rel:cyt_tran_rel:gid_trmFO:gid_trmFO:cobQ:cobQ:kdsB:kdsB:nfo:nfo:reco:reco:cobJ_cbiH:cobJ_cbiH:type_III_tyeA:type_III_tyeA:Poorly characterized:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Replication and Repair:Membrane Transport:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:DNA replication, recombination, and repair:tRNA and rRNA base modification:Heme, porphyrin, and cobalamin:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:DNA metabolism:Protein synthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism" 26 "Energy production and conversion:Energy production and conversion:Ribonuclease HII:Ribonuclease HII:Phosphopantetheinyl transferase (holo-ACP synthase):Phosphopantetheinyl transferase (holo-ACP synthase):N6-adenine-specific methylase:N6-adenine-specific methylase:Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold:Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold:ABC-type transport system involved in resistance to organic solvents, ATPase component:ABC-type transport system involved in resistance to organic solvents, ATPase component:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Multidrug resistance efflux pump:Multidrug resistance efflux pump:Predicted periplasmic or secreted lipoprotein:Predicted periplasmic or secreted lipoprotein:Surface lipoprotein:Surface lipoprotein:Uncharacterized iron-regulated protein:Uncharacterized iron-regulated protein:Response regulator of the LytR/AlgR family:Response regulator of the LytR/AlgR family:Molybdopterin-binding protein:Molybdopterin-binding protein:Ferredoxin-thioredoxin reductase, catalytic subunit:Ferredoxin-thioredoxin reductase, catalytic subunit:Membrane-bound metallopeptidase:Membrane-bound metallopeptidase:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:two-component response regulator activity:two-component signal transduction system (phosphorelay):magnesium ion binding:nucleic acid binding:DNA binding:RNA binding:catalytic activity:metalloendopeptidase activity:endoribonuclease activity:ribonuclease H activity:signal transducer activity:protein binding:ATP binding:DNA recombination:regulation of transcription, DNA-dependent:RNA catabolic process:proteolysis:fatty acid biosynthetic process:transport:signal transduction:metabolic process:methyltransferase activity:zinc ion binding:protein transporter activity:phospholipid biosynthetic process:cardiolipin synthase activity:holo-[acyl-carrier-protein] synthase activity:macromolecule biosynthetic process:protein secretion:DNA integration:molybdate transmembrane-transporting ATPase activity:ATPase activity:molybdenum ion binding:methylation:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:DNA replication:DNA replication:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00095:TIGR00095:acpS:acpS:Mop:Mop:C4_traR_proteo:C4_traR_proteo:Defense mechanisms:Defense mechanisms:Metabolism:Metabolism:Replication and Repair:Metabolism of Cofactors and Vitamins:Lipid Metabolism:Mobile and extrachromosomal element functions:Transport and binding proteins:Protein synthesis:Fatty acid and phospholipid metabolism:Prophage functions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Lipid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Anions:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Anions:tRNA and rRNA base modification:Biosynthesis:Global:Genetic Information Processing" 27 "Energy production and conversion:Energy production and conversion:Ribosome recycling factor:Ribosome recycling factor:Cytosine deaminase and related metal-dependent hydrolases:Cytosine deaminase and related metal-dependent hydrolases:Transcriptional regulator:Transcriptional regulator:tRNA nucleotidyltransferase/poly(A) polymerase:tRNA nucleotidyltransferase/poly(A) polymerase:Nitroreductase:Nitroreductase:6Fe-6S prismane cluster-containing protein:6Fe-6S prismane cluster-containing protein:Metal-dependent hydrolases of the beta-lactamase superfamily II:Metal-dependent hydrolases of the beta-lactamase superfamily II:Adenylate cyclase, class 2 (thermophilic):Adenylate cyclase, class 2 (thermophilic):4-alpha-glucanotransferase:4-alpha-glucanotransferase:Esterase/lipase:Esterase/lipase:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted periplasmic solute-binding protein:Predicted periplasmic solute-binding protein:Putative glycerate kinase:Putative glycerate kinase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:ABC-type molybdate transport system, ATPase component:ABC-type molybdate transport system, ATPase component:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:ABC-type Co2+ transport system, periplasmic component:ABC-type Co2+ transport system, periplasmic component:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:nucleic acid binding:sequence-specific DNA binding transcription factor activity:GTPase activity:carboxylesterase activity:4-alpha-glucanotransferase activity:polynucleotide adenylyltransferase activity:transporter activity:binding:iron ion binding:ATP binding:carbohydrate metabolic process:electron transport:cAMP biosynthetic process:regulation of transcription, DNA-dependent:translation:proteolysis:transport:serine-type peptidase activity:calcium- and calmodulin-responsive adenylate cyclase activity:protein-synthesizing GTPase activity:guanine deaminase activity:biosynthetic process:oxidoreductase activity:hydroxypyruvate reductase activity:oxidoreductase activity, acting on other nitrogenous compounds as donors:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen:hydrolase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:ATPase activity:carbohydrate binding:cation binding:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:RNA degradation:RNA degradation:General function prediction only:General function prediction only:Function unknown:Function unknown:malQ:malQ:frr:frr:TAT_signal_seq:TAT_signal_seq:hybrid_clust:hybrid_clust:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Information storage and processing:Energy metabolism:Amino acids and amines:Biosynthesis and degradation of polysaccharides:Protein synthesis:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Information storage and processing:Metabolism:Poorly characterized:Energy metabolism:Protein and peptide secretion and trafficking:Translation factors:Biosynthesis and degradation of polysaccharides:Amino acids and amines:Global:Genetic Information Processing:Protein synthesis:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Folding Sorting and Degradation:Amino Acid Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Protein fate:Nucleotide Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Metabolism" 28 "Energy production and conversion:Energy production and conversion:Undecaprenyl pyrophosphate synthase:Undecaprenyl pyrophosphate synthase:Glutamate decarboxylase and related PLP-dependent proteins:Glutamate decarboxylase and related PLP-dependent proteins:Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases:Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases:Porphobilinogen deaminase:Porphobilinogen deaminase:Methionyl-tRNA formyltransferase:Methionyl-tRNA formyltransferase:Lipoate-protein ligase B:Lipoate-protein ligase B:DNA primase (bacterial type):DNA primase (bacterial type):Fatty acid/phospholipid biosynthesis enzyme:Fatty acid/phospholipid biosynthesis enzyme:Membrane GTPase LepA:Membrane GTPase LepA:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:DnaJ-class molecular chaperone with C-terminal Zn finger domain:DnaJ-class molecular chaperone with C-terminal Zn finger domain:IMP dehydrogenase/GMP reductase:IMP dehydrogenase/GMP reductase:Uridylate kinase:Uridylate kinase:Signal recognition particle GTPase:Signal recognition particle GTPase:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):CDP-diglyceride synthetase:CDP-diglyceride synthetase:Glycyl-tRNA synthetase, beta subunit:Glycyl-tRNA synthetase, beta subunit:Glycyl-tRNA synthetase, alpha subunit:Glycyl-tRNA synthetase, alpha subunit:Cell division protein FtsI/penicillin-binding protein 2:Cell division protein FtsI/penicillin-binding protein 2:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:Mismatch repair ATPase (MutS family):Mismatch repair ATPase (MutS family):Predicted metal-binding, possibly nucleic acid-binding protein:Predicted metal-binding, possibly nucleic acid-binding protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA primase activity:DNA-directed RNA polymerase activity:GMP reductase activity:GTPase activity:IMP dehydrogenase activity:amidase activity:glycerol-3-phosphate O-acyltransferase activity:hydroxymethylbilane synthase activity:methionyl-tRNA formyltransferase activity:phosphatidate cytidylyltransferase activity:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity:arginine-tRNA ligase activity:glycine-tRNA ligase activity:ATP binding:GTP binding:electron transport:GMP biosynthetic process:pyrimidine nucleotide biosynthetic process:DNA replication, synthesis of RNA primer:DNA repair:mismatch repair:DNA modification:transcription initiation, DNA-dependent:regulation of transcription, DNA-dependent:RNA processing:translation:arginyl-tRNA aminoacylation:glutamyl-tRNA aminoacylation:glycyl-tRNA aminoacylation:methionyl-tRNA aminoacylation:protein folding:protein modification process:cellular amino acid metabolic process:SRP-dependent cotranslational protein targeting to membrane:fatty acid biosynthetic process:cell cycle:tRNA processing:transcription factor binding:metabolic process:zinc ion binding:7S RNA binding:protein-synthesizing GTPase activity:signal-recognition-particle GTPase activity:cellular amino acid biosynthetic process:phospholipid biosynthetic process:penicillin binding:di-trans,poly-cis-decaprenylcistransferase activity:peptidoglycan glycosyltransferase activity:uridylate kinase activity:lipoate biosynthetic process:peptidoglycan-based cell wall biogenesis:response to heat:carboxy-lyase activity:carbon-nitrogen ligase activity, with glutamine as amido-N-donor:ATPase activity:sigma factor activity:nucleoside-triphosphatase activity:carboxylic acid metabolic process:pyridoxal phosphate binding:thiamine pyrophosphate binding:mismatched DNA binding:heat shock protein binding:tetrapyrrole biosynthetic process:indolepyruvate ferredoxin oxidoreductase activity:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity:unfolded protein binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Histidine metabolism:Histidine metabolism:Tyrosine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Tryptophan metabolism:Tryptophan metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Glycerolipid metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:One carbon pool by folate:One carbon pool by folate:Lipoic acid metabolism:Lipoic acid metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:RNA polymerase:RNA polymerase:DNA replication:DNA replication:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Mismatch repair:Mismatch repair:Sulfur relay system:Sulfur relay system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:uppS:uppS:gatA:gatA:plsX:plsX:glyS:glyS:hemC:hemC:lipB:lipB:small_GTP:small_GTP:glyQ:glyQ:trmU:trmU:fmt:fmt:ffh:ffh:IMP_dehydrog:IMP_dehydrog:dnaG:dnaG:pyrH_bact:pyrH_bact:DnaJ_bact:DnaJ_bact:RpoD_Cterm:RpoD_Cterm:IOR_alpha:IOR_alpha:pbp2_mrdA:pbp2_mrdA:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Purines, pyrimidines, nucleosides, and nucleotides:Fatty acid and phospholipid metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Biosynthesis and degradation of murein sacculus and peptidoglycan:Heme, porphyrin, and cobalamin:General:Protein modification and repair:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Purine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Protein and peptide secretion and trafficking:tRNA and rRNA base modification:tRNA aminoacylation:Transcription factors:DNA replication, recombination, and repair:Purine ribonucleotide biosynthesis:Nucleotide and nucleoside interconversions:Biosynthesis:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Signal Transduction:Membrane Transport:Replication and Repair:Folding Sorting and Degradation:Translation:Transcription:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Amino Acid Metabolism:Lipid Metabolism:Nucleotide Metabolism:Nucleotide Metabolism:Lipid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Poorly characterized:Metabolism:Cellular processes and signaling:Metabolism of Terpenoids and Polyketides:Information storage and processing:Genetic Information Processing:Transcription:Translation:Cell envelope:Folding Sorting and Degradation:Biosynthesis of cofactors, prosthetic groups, and carriers:Unknown function:Replication and Repair:Protein fate:Protein synthesis:Environmental Information Processing:Membrane Transport:Transcription:Signal Transduction:DNA metabolism:Global:Metabolism" 29 "Arginyl-tRNA synthetase:Arginyl-tRNA synthetase:Glutamine phosphoribosylpyrophosphate amidotransferase:Glutamine phosphoribosylpyrophosphate amidotransferase:3-polyprenyl-4-hydroxybenzoate decarboxylase:3-polyprenyl-4-hydroxybenzoate decarboxylase:Seryl-tRNA synthetase:Seryl-tRNA synthetase:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):Phosphoheptose isomerase:Phosphoheptose isomerase:Carbamoylphosphate synthase large subunit (split gene in MJ):Carbamoylphosphate synthase large subunit (split gene in MJ):DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):DNA polymerase sliding clamp subunit (PCNA homolog):DNA polymerase sliding clamp subunit (PCNA homolog):Sulfate permease and related transporters (MFS superfamily):Sulfate permease and related transporters (MFS superfamily):Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit:Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit:Membrane proteins related to metalloendopeptidases:Membrane proteins related to metalloendopeptidases:Predicted ATP-dependent protease:Predicted ATP-dependent protease:NCAIR mutase (PurE)-related proteins:NCAIR mutase (PurE)-related proteins:4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase:4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase:Ribosomal protein L11 methylase:Ribosomal protein L11 methylase:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:sequence-specific DNA binding transcription factor activity:translation elongation factor activity:DNA-directed DNA polymerase activity:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:DNA topoisomerase (ATP-hydrolyzing) activity:GTPase activity:amidophosphoribosyltransferase activity:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity:carbonate dehydratase activity:ATP-dependent peptidase activity:metalloendopeptidase activity:serine-type endopeptidase activity:phosphoribosylaminoimidazole carboxylase activity:arginine-tRNA ligase activity:serine-tRNA ligase activity:ATP binding:carbohydrate metabolic process:'de novo' IMP biosynthetic process:DNA replication:DNA topological change:DNA unwinding involved in replication:transcription initiation, DNA-dependent:regulation of transcription, DNA-dependent:translational elongation:arginyl-tRNA aminoacylation:glutamyl-tRNA aminoacylation:seryl-tRNA aminoacylation:regulation of translational fidelity:protein methylation:proteolysis:arginine biosynthetic process:ubiquinone biosynthetic process:secondary active sulfate transmembrane transporter activity:sulfate transport:protein methyltransferase activity:3'-5' exonuclease activity:protein-synthesizing GTPase activity:3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity:D-sedoheptulose 7-phosphate isomerase activity:purine base biosynthetic process:nucleoside metabolic process:lipopolysaccharide core region biosynthetic process:terpenoid biosynthetic process:phosphorylation:carboxy-lyase activity:sigma factor activity:pyrimidine base biosynthetic process:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:RNA polymerase:RNA polymerase:DNA replication:DNA replication:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:efp:efp:gatC:gatC:ispE:ispE:serS:serS:ubiX_pad:ubiX_pad:argS:argS:dnan:dnan:sulP:sulP:gyrB:gyrB:gyrA:gyrA:purF:purF:CPSaseII_lrg:CPSaseII_lrg:sigma70-ECF:sigma70-ECF:Transcription:Replication and Repair:Metabolism:Metabolism:Genetic Information Processing:Global:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:DNA replication, recombination, and repair:tRNA aminoacylation:Translation factors:Anions:Enzymes of unknown specificity:Other:Purines, pyrimidines, nucleosides, and nucleotides:DNA metabolism:Protein synthesis:Transport and binding proteins:Unknown function:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Transcription:Translation:Replication and Repair:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Translation factors:Transport and binding proteins:Anions:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation" 30 "Energy production and conversion:Energy production and conversion:Pseudouridylate synthase:Pseudouridylate synthase:Methionyl-tRNA synthetase:Methionyl-tRNA synthetase:Glutamate 5-kinase:Glutamate 5-kinase:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Uncharacterized conserved protein:Uncharacterized conserved protein:Glycosyltransferases involved in cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:Glycerophosphoryl diester phosphodiesterase:Glycerophosphoryl diester phosphodiesterase:Selenophosphate synthase:Selenophosphate synthase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:dTDP-D-glucose 4,6-dehydratase:dTDP-D-glucose 4,6-dehydratase:dTDP-4-dehydrorhamnose reductase:dTDP-4-dehydrorhamnose reductase:GTPase:GTPase:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized FAD-dependent dehydrogenases:Uncharacterized FAD-dependent dehydrogenases:Predicted transcriptional regulator with C-terminal CBS domains:Predicted transcriptional regulator with C-terminal CBS domains:DNA uptake lipoprotein:DNA uptake lipoprotein:Cobalamin biosynthesis protein CbiK, Co2+ chelatase:Cobalamin biosynthesis protein CbiK, Co2+ chelatase:Amino acid transport and metabolism:Amino acid transport and metabolism:tRNA binding:pseudouridine synthesis:nucleic acid binding:RNA binding:catalytic activity:biotin synthase activity:glutamate 5-kinase activity:pseudouridylate synthase activity:selenide, water dikinase activity:methionine-tRNA ligase activity:binding:ATP binding:GTP binding:glycerol metabolic process:electron transport:tRNA modification:tRNA aminoacylation for protein translation:methionyl-tRNA aminoacylation:proline biosynthetic process:metabolic process:dTDP-glucose 4,6-dehydratase activity:dTDP-4-dehydrorhamnose reductase activity:glycerophosphodiester phosphodiesterase activity:hydroxymethylpyrimidine kinase activity:phosphomethylpyrimidine kinase activity:nucleotide-sugar metabolic process:thiamine biosynthetic process:pseudouridine synthase activity:ferrous iron transmembrane transporter activity:ferrous iron transport:oxidoreductase activity:sirohydrochlorin cobaltochelatase activity:indolepyruvate ferredoxin oxidoreductase activity:extracellular polysaccharide biosynthetic process:coenzyme binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Arginine and proline metabolism:Arginine and proline metabolism:Selenocompound metabolism:Selenocompound metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Polyketide sugar unit biosynthesis:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Thiamine metabolism:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:General function prediction only:General function prediction only:Function unknown:Function unknown:HMP-P_kinase:HMP-P_kinase:small_GTP:small_GTP:metG:metG:selD:selD:proB:proB:dTDP_gluc_dehyt:dTDP_gluc_dehyt:rmlD:rmlD:Metabolism:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Metabolism:Poorly characterized:Protein synthesis:tRNA aminoacylation:Unknown function:General:Amino acid biosynthesis:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Cell envelope:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino acid biosynthesis:Unknown function:Protein synthesis:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Thiamine:Lipid Metabolism:Glutamate family:General:tRNA aminoacylation:Global:Genetic Information Processing:Metabolism:Metabolism:Translation:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Genetic Information Processing:Translation:Global" 31 "Energy production and conversion:Energy production and conversion:Ammonia permease:Ammonia permease:Nitrogen regulatory protein PII:Nitrogen regulatory protein PII:Predicted GTPase:Predicted GTPase:Glycerol-3-phosphate dehydrogenase:Glycerol-3-phosphate dehydrogenase:Signal transduction histidine kinase:Signal transduction histidine kinase:Uncharacterized protein required for formate dehydrogenase activity:Uncharacterized protein required for formate dehydrogenase activity:ATP sulfurylase (sulfate adenylyltransferase):ATP sulfurylase (sulfate adenylyltransferase):Peroxiredoxin:Peroxiredoxin:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Predicted signal-transduction protein containing cAMP-binding and CBS domains:Predicted signal-transduction protein containing cAMP-binding and CBS domains:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Site-specific recombinase XerD:Site-specific recombinase XerD:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:sulfate assimilation:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:GTPase activity:glycerol-3-phosphate dehydrogenase activity:sulfate adenylyltransferase (ATP) activity:ATP binding:GTP binding:glycerol-3-phosphate metabolic process:electron transport:DNA recombination:regulation of transcription, DNA-dependent:tRNA modification:sulfur compound metabolic process:regulation of nitrogen utilization:transport:response to oxidative stress:cell cycle:chromosome segregation:signal transduction:transcription factor binding:metabolic process:thioredoxin peroxidase activity:ammonium transmembrane transporter activity:formate dehydrogenase (NAD+) activity:cyclic nucleotide biosynthetic process:DNA integration:ferrous iron transmembrane transporter activity:ferrous iron transport:phosphorus-oxygen lyase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:enzyme regulator activity:intracellular signal transduction:cell division:Replication, recombination and repair:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Selenocompound metabolism:Selenocompound metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:small_GTP:small_GTP:sopT:sopT:amt:amt:recomb_XerD:recomb_XerD:phageshock_pspF:phageshock_pspF:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Cations and iron carrying compounds:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Metabolism:Metabolism:Environmental Information Processing:Global:Sulfur metabolism:DNA interactions:Small molecule interactions:DNA replication, recombination, and repair:Cations and iron carrying compounds:General:Central intermediary metabolism:Regulatory functions:DNA metabolism:Transport and binding proteins:Unknown function:Signal Transduction:Metabolism of Other Amino Acids:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Metabolism of Other Amino Acids:Environmental Information Processing:Signal Transduction:Global:Metabolism:Central intermediary metabolism:Sulfur metabolism:Regulatory functions:DNA interactions:Small molecule interactions" 32 "Chorismate synthase:Chorismate synthase:Orotidine-5'-phosphate decarboxylase:Orotidine-5'-phosphate decarboxylase:Lipoate-protein ligase B:Lipoate-protein ligase B:Homoserine dehydrogenase:Homoserine dehydrogenase:Single-stranded DNA-specific exonuclease:Single-stranded DNA-specific exonuclease:Shikimate kinase:Shikimate kinase:Chromate transport protein ChrA:Chromate transport protein ChrA:Signal transduction histidine kinase:Signal transduction histidine kinase:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:catalytic activity:chorismate synthase activity:homoserine dehydrogenase activity:orotidine-5'-phosphate decarboxylase activity:shikimate kinase activity:transporter activity:ATP binding:'de novo' pyrimidine base biosynthetic process:DNA repair:DNA recombination:regulation of transcription, DNA-dependent:protein modification process:transport:5'-3' exonuclease activity:cellular amino acid biosynthetic process:aromatic amino acid family biosynthetic process:lipoate biosynthetic process:chromate transmembrane transporter activity:chromate transport:amino acid binding:peptidyl-histidine phosphorylation:manganese ion binding:sequence-specific DNA binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Lysine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Lipoic acid metabolism:Lipoic acid metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Base excision repair:Base excision repair:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:Signal transduction mechanisms:Signal transduction mechanisms:aroC:aroC:lipB:lipB:sensory_box:sensory_box:recJ:recJ:2A51:2A51:pyrF:pyrF:DNA metabolism:Genetic Information Processing:Replication and Repair:Regulatory functions:Purines, pyrimidines, nucleosides, and nucleotides:Aromatic amino acid family:Global:Metabolism:Anions:Protein modification and repair:DNA replication, recombination, and repair:Small molecule interactions:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein modification and repair:Transport and binding proteins:Anions:Amino acid biosynthesis:Aromatic amino acid family:Information storage and processing:Cellular processes and signaling:Metabolism:Pyrimidine ribonucleotide biosynthesis:Global:Genetic Information Processing:Metabolism:Metabolism:Replication and Repair:Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Metabolism:Nucleotide Metabolism:Cellular processes and signaling:Amino Acid Metabolism:Information storage and processing:Amino acid biosynthesis:Transport and binding proteins:Protein fate:Metabolism of Cofactors and Vitamins" 33 "Energy production and conversion:Energy production and conversion:Phosphate/sulphate permeases:Phosphate/sulphate permeases:4-hydroxybenzoate polyprenyltransferase and related prenyltransferases:4-hydroxybenzoate polyprenyltransferase and related prenyltransferases:Permeases of the drug/metabolite transporter (DMT) superfamily:Permeases of the drug/metabolite transporter (DMT) superfamily:Uncharacterized membrane protein, putative virulence factor:Uncharacterized membrane protein, putative virulence factor:Membrane proteins related to metalloendopeptidases:Membrane proteins related to metalloendopeptidases:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Pyridoxal phosphate biosynthesis protein:Pyridoxal phosphate biosynthesis protein:ABC-type cobalt transport system, ATPase component:ABC-type cobalt transport system, ATPase component:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted signal transduction protein:Predicted signal transduction protein:ABC-type Na+ efflux pump, permease component:ABC-type Na+ efflux pump, permease component:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Predicted membrane protein:Uncharacterized conserved protein:Uncharacterized conserved protein:ABC-type phosphate/phosphonate transport system, permease component:ABC-type phosphate/phosphonate transport system, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:sequence-specific DNA binding transcription factor activity:catalytic activity:cysteine-type endopeptidase activity:metalloendopeptidase activity:hydroxymethylbilane synthase activity:prenyltransferase activity:signal transducer activity:inorganic phosphate transmembrane transporter activity:ATP binding:regulation of transcription, DNA-dependent:proteolysis:transport:phosphate ion transport:chemotaxis:signal transduction:pyridoxine biosynthetic process:cyclic nucleotide biosynthetic process:pathogenesis:phosphonate transmembrane transporter activity:phosphonate transport:phosphorus-oxygen lyase activity:ATPase activity:tetrapyrrole biosynthetic process:intracellular signal transduction:ATPase activity, coupled to transmembrane movement of substances:sequence-specific DNA binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Vitamin B6 metabolism:Vitamin B6 metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00159:TIGR00159:GGDEF:GGDEF:pdxJ:pdxJ:PhnE:PhnE:ubiA_other:ubiA_other:mviN:mviN:Poorly characterized:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Anions:Global:Conserved:General:Menaquinone and ubiquinone:Pyridoxine:Other:Transport and binding proteins:Hypothetical proteins:Unknown function:Biosynthesis of cofactors, prosthetic groups, and carriers:Signal transduction:Cellular Processes:Environmental Information Processing:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Transport and binding proteins:Anions:Hypothetical proteins:Conserved:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Pyridoxine:Signal transduction:Other:Cellular processes and signaling:Metabolism" 34 "Energy production and conversion:Energy production and conversion:7-keto-8-aminopelargonate synthetase and related enzymes:7-keto-8-aminopelargonate synthetase and related enzymes:Fe2+ transport system protein B:Fe2+ transport system protein B:Flavodoxins:Flavodoxins:Fe2+ transport system protein A:Fe2+ transport system protein A:FOG: GGDEF domain:FOG: GGDEF domain:AraC-type DNA-binding domain-containing proteins:AraC-type DNA-binding domain-containing proteins:Cation transport ATPase:Cation transport ATPase:DNA gyrase inhibitor:DNA gyrase inhibitor:nucleoside binding:DNA binding:sequence-specific DNA binding transcription factor activity:copper-exporting ATPase activity:receptor activity:transporter activity:iron ion binding:ATP binding:GTP binding:electron transport:regulation of transcription, DNA-dependent:transport:microtubule-based process:metabolic process:cation transmembrane transporter activity:8-amino-7-oxononanoate synthase activity:electron carrier activity:biosynthetic process:cyclic nucleotide biosynthetic process:FMN binding:ferrous iron transmembrane transporter activity:ferrous iron transport:transferase activity, transferring nitrogenous groups:phosphorus-oxygen lyase activity:metal ion transport:pyridoxal phosphate binding:intracellular signal transduction:sequence-specific DNA binding:metal ion binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Biotin metabolism:Biotin metabolism:Metabolic pathways:Metabolic pathways:Signal transduction mechanisms:Signal transduction mechanisms:GGDEF:GGDEF:feoB:feoB:ATPase-IB_hvy:ATPase-IB_hvy:flav_short:flav_short:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Other:Cations and iron carrying compounds:Electron transport:Global:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Signal transduction:Transport and binding proteins:Energy metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Energy metabolism:Electron transport:Transport and binding proteins:Cations and iron carrying compounds" 35 "Energy production and conversion:Energy production and conversion:Aspartyl/asparaginyl-tRNA synthetases:Aspartyl/asparaginyl-tRNA synthetases:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Aspartate-semialdehyde dehydrogenase:Aspartate-semialdehyde dehydrogenase:Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase:Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase:Predicted hydrolase of the alpha/beta-hydrolase fold:Predicted hydrolase of the alpha/beta-hydrolase fold:Uncharacterized NAD(FAD)-dependent dehydrogenases:Uncharacterized NAD(FAD)-dependent dehydrogenases:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Zn-dependent hydrolases, including glyoxylases:Zn-dependent hydrolases, including glyoxylases:ATPase components of various ABC-type transport systems, contain duplicated ATPase:ATPase components of various ABC-type transport systems, contain duplicated ATPase:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Uncharacterized conserved protein:Uncharacterized conserved protein:Histidinol phosphatase and related hydrolases of the PHP family:Histidinol phosphatase and related hydrolases of the PHP family:Alcohol dehydrogenase, class IV:Alcohol dehydrogenase, class IV:Multidrug resistance efflux pump:Multidrug resistance efflux pump:Uncharacterized conserved protein:Uncharacterized conserved protein:FOG: PAS/PAC domain:FOG: PAS/PAC domain:Hemerythrin:Hemerythrin:Uncharacterized protein involved in outer membrane biogenesis:Uncharacterized protein involved in outer membrane biogenesis:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Response regulator containing a CheY-like receiver domain and a GGDEF domain:ABC-type spermidine/putrescine transport systems, ATPase components:ABC-type spermidine/putrescine transport systems, ATPase components:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:histidine biosynthetic process:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:DNA-directed DNA polymerase activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:aspartate-semialdehyde dehydrogenase activity:branched-chain-amino-acid transaminase activity:histidinol-phosphatase activity:hydroxyacylglutathione hydrolase activity:endonuclease activity:aspartate-tRNA ligase activity:asparagine-tRNA ligase activity:signal transducer activity:binding:ATP binding:electron transport:DNA replication:mismatch repair:regulation of transcription, DNA-dependent:asparaginyl-tRNA aminoacylation:aspartyl-tRNA aminoacylation:protein complex assembly:signal transduction:metabolic process:protein transporter activity:biosynthetic process:methionine biosynthetic process:threonine biosynthetic process:cyclic nucleotide biosynthetic process:cobalamin biosynthetic process:protein secretion:putrescine-importing ATPase activity:spermidine-importing ATPase activity:nickel ion binding:oxidoreductase activity:transcription repressor activity:transferase activity, transferring nitrogenous groups:hydrolase activity:phosphorus-oxygen lyase activity:ATPase activity:peptidyl-histidine phosphorylation:pyridoxal phosphate binding:mismatched DNA binding:intracellular signal transduction:cobyrinic acid a,c-diamide synthase activity:cell redox homeostasis:negative regulation of transcription, DNA-dependent:metal ion binding:protein dimerization activity:NADP binding:coenzyme binding:NAD binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Lysine biosynthesis:Histidine metabolism:Histidine metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:hypB:hypB:sensory_box:sensory_box:asnS:asnS:asd_B:asd_B:hisJ_fam:hisJ_fam:hemeryth_dom:hemeryth_dom:Defense mechanisms:Defense mechanisms:Protein fate:Protein modification and repair:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Regulatory functions:Aspartate family:Protein modification and repair:Amino acid biosynthesis:Protein synthesis:tRNA aminoacylation:Small molecule interactions:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Small molecule interactions:Regulatory functions:Metabolism:Membrane Transport:Translation:Metabolism of Cofactors and Vitamins:Metabolism:Global:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Protein synthesis:Amino Acid Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Protein fate:tRNA aminoacylation" 36 "Energy production and conversion:Energy production and conversion:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Glycerol-3-phosphate dehydrogenase:Glycerol-3-phosphate dehydrogenase:ABC-type antimicrobial peptide transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:Flagellar basal body protein:Flagellar basal body protein:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Soluble P-type ATPase:Soluble P-type ATPase:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:motor activity:glycerol-3-phosphate dehydrogenase activity:monooxygenase activity:structural molecule activity:ATP binding:glycerol-3-phosphate metabolic process:regulation of transcription, DNA-dependent:cellular aromatic compound metabolic process:metabolic process:transaminase activity:cyclic nucleotide biosynthetic process:phosphorus-oxygen lyase activity:ATPase activity:peptidyl-histidine phosphorylation:pyridoxal phosphate binding:intracellular signal transduction:serine-glyoxylate transaminase activity:Cell motility:Cell motility:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:GGDEF:GGDEF:FlgB:FlgB:flgA_cterm:flgA_cterm:glycerol3P_GlpA:glycerol3P_GlpA:Defense mechanisms:Defense mechanisms:Other:Energy metabolism:Anaerobic:Regulatory functions:Small molecule interactions:Cellular processes:Chemotaxis and motility:Signal transduction:Other:Cellular processes and signaling:Metabolism:Poorly characterized:Chemotaxis and motility:Small molecule interactions:Anaerobic:Cellular Processes:Metabolism:Cell Motility:Lipid Metabolism:Signal transduction:Cellular processes:Regulatory functions:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Lipid Metabolism:Energy metabolism:Cellular Processes:Cell Motility" 37 "Energy production and conversion:Energy production and conversion:Aspartate/tyrosine/aromatic aminotransferase:Aspartate/tyrosine/aromatic aminotransferase:Acetyltransferases:Acetyltransferases:Cation transport ATPase:Cation transport ATPase:UDP-glucose 4-epimerase:UDP-glucose 4-epimerase:Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain:Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain:Uncharacterized flagellar protein FlaG:Uncharacterized flagellar protein FlaG:Flagellar motor protein:Flagellar motor protein:Predicted signal transduction protein:Predicted signal transduction protein:Na+/H+ antiporter:Na+/H+ antiporter:Chemotaxis protein; stimulates methylation of MCP proteins:Chemotaxis protein; stimulates methylation of MCP proteins:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized homolog of phage Mu protein gp47:Uncharacterized homolog of phage Mu protein gp47:Response regulator:Response regulator:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):catalytic activity:UDP-glucose 4-epimerase activity:L-aspartate:2-oxoglutarate aminotransferase activity:ATP binding:carbohydrate metabolic process:galactose metabolic process:regulation of transcription, DNA-dependent:sodium ion transport:regulation of pH:N-acetyltransferase activity:metabolic process:biosynthetic process:sodium:hydrogen antiporter activity:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism:proton transport:transferase activity, transferring nitrogenous groups:pyridoxal phosphate binding:protein-glutamine glutaminase activity:coenzyme binding:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Galactose metabolism:Galactose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:antiport_nhaC:antiport_nhaC:galE:galE:ATPase_P-type:ATPase_P-type:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cations and iron carrying compounds:Transport and binding proteins:Cellular Processes:Energy Metabolism:Sugars:Global:Carbohydrate Metabolism:Metabolism:Poorly characterized:Cellular Processes:Metabolism:Metabolism:Cell Motility:Energy Metabolism:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Energy metabolism:Metabolism:Global:Cell Motility:Energy metabolism:Sugars:Transport and binding proteins:Cations and iron carrying compounds" 38 "Nitrogen regulatory protein PII:Nitrogen regulatory protein PII:Predicted esterase of the alpha-beta hydrolase superfamily:Predicted esterase of the alpha-beta hydrolase superfamily:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Response regulator containing a CheY-like receiver domain and a GGDEF domain:ABC-type molybdate transport system, ATPase component:ABC-type molybdate transport system, ATPase component:Mu-like prophage tail protein gpP:Mu-like prophage tail protein gpP:Mu-like prophage protein gp46:Mu-like prophage protein gp46:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):catalytic activity:ATP binding:regulation of transcription, DNA-dependent:lipid metabolic process:regulation of nitrogen utilization:cyclic nucleotide biosynthetic process:phosphorus-oxygen lyase activity:ATPase activity:enzyme regulator activity:intracellular signal transduction:nutrient reservoir activity:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Nitrogen metabolism:Nitrogen metabolism:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:GGDEF:GGDEF:Cellular processes and signaling:Signal transduction:Other:Cellular processes and signaling:Metabolism:Poorly characterized:Signal transduction:Other:Environmental Information Processing:Metabolism:Membrane Transport:Energy Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Metabolism:Environmental Information Processing:Membrane Transport" 39 "Predicted amidohydrolase:Predicted amidohydrolase:Uncharacterized NAD(FAD)-dependent dehydrogenases:Uncharacterized NAD(FAD)-dependent dehydrogenases:Predicted transcriptional regulator:Predicted transcriptional regulator:Predicted permease, DMT superfamily:Predicted permease, DMT superfamily:DNA binding:amidase activity:formamidase activity:iron ion binding:nitrogen compound metabolic process:transcription repressor activity:negative regulation of transcription, DNA-dependent:Transcription:Transcription:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Nitrogen metabolism:Nitrogen metabolism:General function prediction only:General function prediction only:rrf2_super:rrf2_super:General:Information storage and processing:Poorly characterized:Energy Metabolism:Carbohydrate Metabolism:General:Metabolism:Unknown function:Information storage and processing:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Unknown function" 40 "Mu-like prophage FluMu protein gp28:Mu-like prophage FluMu protein gp28:Mu-like prophage protein gp16:Mu-like prophage protein gp16:Mu-like prophage protein gp36:Mu-like prophage protein gp36:Phage-related terminase:Phage-related terminase:General function prediction only:General function prediction only:Function unknown:Function unknown:Poorly characterized:Poorly characterized" 41 "Shikimate 5-dehydrogenase:Shikimate 5-dehydrogenase:5-formyltetrahydrofolate cyclo-ligase:5-formyltetrahydrofolate cyclo-ligase:FOG: CheY-like receiver:FOG: CheY-like receiver:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):shikimate 3-dehydrogenase (NADP+) activity:transporter activity:binding:ATP binding:regulation of transcription, DNA-dependent:transport:folic acid-containing compound biosynthetic process:peptidyl-histidine phosphorylation:5-formyltetrahydrofolate cyclo-ligase activity:quinate/shikimate dehydrogenase activity:NADP binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:One carbon pool by folate:One carbon pool by folate:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:aroE:aroE:MTHFS_bact:MTHFS_bact:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism:Global:Metabolism:Metabolism:Cellular processes and signaling:Amino acid biosynthesis:Regulatory functions:Central intermediary metabolism:Central intermediary metabolism:One-carbon metabolism:Regulatory functions:Small molecule interactions:Amino acid biosynthesis:Aromatic amino acid family:Cellular processes and signaling:Metabolism:Aromatic amino acid family:Small molecule interactions:One-carbon metabolism:Global:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism" 42 "Periplasmic serine proteases (ClpP class):Periplasmic serine proteases (ClpP class):Transposase and inactivated derivatives:Transposase and inactivated derivatives:DNA binding:transposase activity:transposition, DNA-mediated:proteolysis:peptidase activity:Replication, recombination and repair:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Information storage and processing:Cellular processes and signaling:Cellular processes and signaling" 43 "Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain):Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain):Predicted metal-dependent hydrolase of the TIM-barrel fold:Predicted metal-dependent hydrolase of the TIM-barrel fold:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Phage-related holin (Lysis protein):Phage-related holin (Lysis protein):Flp pilus assembly protein TadD, contains TPR repeats:Flp pilus assembly protein TadD, contains TPR repeats:two-component signal transduction system (phosphorelay):nucleotide binding:sequence-specific DNA binding transcription factor activity:catalytic activity:binding:ATP binding:carbohydrate metabolic process:regulation of transcription, DNA-dependent:transcription factor binding:metabolic process:nitrogen fixation:transcription activator activity:nucleoside-triphosphatase activity:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Two-component system:Two-component system:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:CoA_E_activ:CoA_E_activ:holin_tox_secr:holin_tox_secr:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Environmental Information Processing:Signal Transduction:Mobile and extrachromosomal element functions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Signal Transduction:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Prophage functions" 44 "Glutamine amidotransferase:Glutamine amidotransferase:Pseudouridine synthase:Pseudouridine synthase:Ribosomal protein S15P/S13E:Ribosomal protein S15P/S13E:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Cytosine/adenosine deaminases:Cytosine/adenosine deaminases:Biopolymer transport proteins:Biopolymer transport proteins:Biopolymer transport protein:Biopolymer transport protein:Phosphate transport regulator (distant homolog of PhoU):Phosphate transport regulator (distant homolog of PhoU):Mg/Co/Ni transporter MgtE (contains CBS domain):Mg/Co/Ni transporter MgtE (contains CBS domain):Membrane protein involved in colicin uptake:Membrane protein involved in colicin uptake:Predicted membrane protein:Predicted membrane protein:Site-specific recombinase XerC:Site-specific recombinase XerC:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:histidine biosynthetic process:DNA binding:RNA binding:structural constituent of ribosome:catalytic activity:dCMP deaminase activity:long-chain fatty acid-CoA ligase activity:pseudouridylate synthase activity:transporter activity:iron ion transmembrane transporter activity:ATP binding:DNA recombination:tRNA modification:translation:glutamine metabolic process:sulfur compound metabolic process:transport:cation transport:iron ion transport:metabolic process:zinc ion binding:cation transmembrane transporter activity:protein transporter activity:pyruvate, water dikinase activity:pseudouridine synthase activity:protein transport:DNA integration:proton transport:phosphorylation:transferase activity, transferring pentosyl groups:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances:tRNA pseudouridine synthesis:short-chain fatty acid-CoA ligase activity:medium-chain fatty acid-CoA ligase activity:very long-chain fatty acid-CoA ligase activity:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Histidine metabolism:Histidine metabolism:Pyruvate metabolism:Pyruvate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Ribosome:Ribosome:Function unknown:Function unknown:mgtE:mgtE:TruB:TruB:S15_bact:S15_bact:tonB_Cterm:tonB_Cterm:IMP_synth_hisH:IMP_synth_hisH:tolQ:tolQ:tolR:tolR:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Cellular processes and signaling:Information storage and processing:Metabolism:tRNA and rRNA base modification:Protein synthesis:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Pathogenesis:Amino acid biosynthesis:Histidine family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation:Amino Acid Metabolism:Metabolism:Energy Metabolism:Carbohydrate Metabolism:Genetic Information Processing:Cations and iron carrying compounds:Global:Ribosomal proteins: synthesis and modification:Amino acid biosynthesis:Cellular processes:Transport and binding proteins:Protein synthesis:Histidine family:Pathogenesis:Energy Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Carbohydrate Metabolism:Global:Metabolism:Metabolism:Poorly characterized" 45 "Ribosomal protein L11:Ribosomal protein L11:Ribosomal protein L3:Ribosomal protein L3:Ribosomal protein S13:Ribosomal protein S13:Ribosomal protein S11:Ribosomal protein S11:Ribosomal protein L13:Ribosomal protein L13:DNA-directed RNA polymerase, alpha subunit/40 kD subunit:DNA-directed RNA polymerase, alpha subunit/40 kD subunit:Ribosomal protein L17:Ribosomal protein L17:Ribosomal protein L10:Ribosomal protein L10:Phosphoribosylpyrophosphate synthetase:Phosphoribosylpyrophosphate synthetase:Ribosomal protein S4 and related proteins:Ribosomal protein S4 and related proteins:Ribosomal protein L25 (general stress protein Ctc):Ribosomal protein L25 (general stress protein Ctc):Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:magnesium ion binding:DNA binding:RNA binding:structural constituent of ribosome:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:ribose phosphate diphosphokinase activity:transcription, DNA-dependent:translation:5S rRNA binding:nucleoside metabolic process:ribonucleoside monophosphate biosynthetic process:lipoate-protein ligase activity:rRNA binding:ribosome biogenesis:protein dimerization activity:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Pentose phosphate pathway:Pentose phosphate pathway:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Ribosome:Ribosome:RNA polymerase:RNA polymerase:L17:L17:ctc_TL5:ctc_TL5:rpsD_bact:rpsD_bact:rpmJ_bact:rpmJ_bact:rplM_bact:rplM_bact:ribP_PPkin:ribP_PPkin:L11_bact:L11_bact:rpoA:rpoA:L3_bact:L3_bact:bact_S13:bact_S13:bact_S11:bact_S11:Translation:Transcription:Genetic Information Processing:Nucleotide Metabolism:Carbohydrate Metabolism:Metabolism:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Transcription:DNA-dependent RNA polymerase:Protein synthesis:Ribosomal proteins: synthesis and modification:Information storage and processing:Metabolism:Metabolism:Information storage and processing:Carbohydrate Metabolism:Nucleotide Metabolism:Transcription:Translation:Protein synthesis:Transcription:Purines, pyrimidines, nucleosides, and nucleotides:Ribosomal proteins: synthesis and modification:DNA-dependent RNA polymerase:Purine ribonucleotide biosynthesis:Global:Genetic Information Processing:Metabolism:Metabolism:Global" 46 "Energy production and conversion:Energy production and conversion:Gamma-glutamyl phosphate reductase:Gamma-glutamyl phosphate reductase:3-isopropylmalate dehydratase large subunit:3-isopropylmalate dehydratase large subunit:3-isopropylmalate dehydratase small subunit:3-isopropylmalate dehydratase small subunit:Isopropylmalate/homocitrate/citramalate synthases:Isopropylmalate/homocitrate/citramalate synthases:Uncharacterized conserved protein:Uncharacterized conserved protein:Isocitrate/isopropylmalate dehydrogenase:Isocitrate/isopropylmalate dehydrogenase:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:K+ transport systems, NAD-binding component:K+ transport systems, NAD-binding component:ABC-type antimicrobial peptide transport system, permease component:ABC-type antimicrobial peptide transport system, permease component:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:A/G-specific DNA glycosylase:A/G-specific DNA glycosylase:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Precorrin isomerase:Precorrin isomerase:Uncharacterized conserved protein:Uncharacterized conserved protein:Outer membrane lipoprotein-sorting protein:Outer membrane lipoprotein-sorting protein:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Amino acid transport and metabolism:Amino acid transport and metabolism:sequence-specific DNA binding transcription factor activity:2-isopropylmalate synthase activity:3-isopropylmalate dehydratase activity:3-isopropylmalate dehydrogenase activity:biotin synthase activity:ferredoxin-NADP+ reductase activity:glutamate-5-semialdehyde dehydrogenase activity:glutamate synthase (NADPH) activity:endonuclease activity:phosphogluconate dehydrogenase (decarboxylating) activity:iron ion binding:calcium ion binding:ATP binding:pentose-phosphate shunt:electron transport:pyrimidine nucleotide biosynthetic process:base-excision repair:regulation of transcription, DNA-dependent:protein dephosphorylation:proline biosynthetic process:potassium ion transport:transcription factor binding:protein tyrosine/serine/threonine phosphatase activity:metabolic process:cation transmembrane transporter activity:electron carrier activity:leucine biosynthetic process:biotin biosynthetic process:thiamine biosynthetic process:cobalamin biosynthetic process:protein transport:NADPH-adrenodoxin reductase activity:oxidoreductase activity:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:precorrin-8X methylmutase activity:nucleoside-triphosphatase activity:DNA N-glycosylase activity:(R)-2-methylmalate dehydratase activity:flavin adenine dinucleotide binding:NADP binding:iron-sulfur cluster binding:2 iron, 2 sulfur cluster binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Pyruvate metabolism:Pyruvate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Thiamine metabolism:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Base excision repair:Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00149_YbjQ:TIGR00149_YbjQ:leuB:leuB:unchar_dom_1:unchar_dom_1:proA:proA:lolA:lolA:leuA_bact:leuA_bact:mutY:mutY:hacA_fam:hacA_fam:LEUD_arch:LEUD_arch:thiH:thiH:Defense mechanisms:Defense mechanisms:Amino acid biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Glutamate family:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Protein fate:DNA metabolism:Poorly characterized:Metabolism:Thiamine:Pyruvate family:Glutamate family:Enzymes of unknown specificity:Protein and peptide secretion and trafficking:DNA replication, recombination, and repair:Carbohydrate Metabolism:Global:Biosynthesis of cofactors, prosthetic groups, and carriers:Replication and Repair:Genetic Information Processing:Metabolism:Metabolism of Cofactors and Vitamins:Information storage and processing:Amino Acid Metabolism:Cellular processes and signaling:Metabolism:Carbohydrate Metabolism:Global:Genetic Information Processing:Metabolism:Metabolism:Replication and Repair:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Unknown function" 47 "Energy production and conversion:Energy production and conversion:Nitrogenase molybdenum-iron protein, alpha and beta chains:Nitrogenase molybdenum-iron protein, alpha and beta chains:Predicted permease, DMT superfamily:Predicted permease, DMT superfamily:DNA binding:electron transport:nitrogen fixation:nitrogenase activity:transcription repressor activity:iron-iron nitrogenase activity:molybdenum-iron nitrogenase activity:vanadium-iron nitrogenase activity:negative regulation of transcription, DNA-dependent:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:nifK:nifK:EpsI_fam:EpsI_fam:Metabolism:Energy Metabolism:Global:Xenobiotics Biodegradation and Metabolism:Metabolism:Global:Metabolism:Unknown substrate:Xenobiotics Biodegradation and Metabolism:Central intermediary metabolism:Nitrogen fixation:Transport and binding proteins:Unknown substrate:Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Central intermediary metabolism:Transport and binding proteins:Nitrogen fixation:Metabolism:Poorly characterized" 48 "Energy production and conversion:Energy production and conversion:Trk-type K+ transport systems, membrane components:Trk-type K+ transport systems, membrane components:Anaerobic dehydrogenases, typically selenocysteine-containing:Anaerobic dehydrogenases, typically selenocysteine-containing:1,4-alpha-glucan branching enzyme:1,4-alpha-glucan branching enzyme:Predicted divalent heavy-metal cations transporter:Predicted divalent heavy-metal cations transporter:Predicted permease:Predicted permease:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Adenine deaminase:Adenine deaminase:Predicted ATP-dependent serine protease:Predicted ATP-dependent serine protease:Heme/copper-type cytochrome/quinol oxidase, subunit 3:Heme/copper-type cytochrome/quinol oxidase, subunit 3:Sugar transferases involved in lipopolysaccharide synthesis:Sugar transferases involved in lipopolysaccharide synthesis:Surface lipoprotein:Surface lipoprotein:Predicted ATPase involved in cell division:Predicted ATPase involved in cell division:Chemotaxis protein:Chemotaxis protein:Predicted periplasmic protein:Predicted periplasmic protein:Predicted permease, DMT superfamily:Predicted permease, DMT superfamily:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:adenine deaminase activity:succinate dehydrogenase activity:damaged DNA binding:1,4-alpha-glucan branching enzyme activity:methylated-DNA-[protein]-cysteine S-methyltransferase activity:hydrogen-transporting two-sector ATPase activity:cytochrome-c oxidase activity:ATP-dependent peptidase activity:aspartic-type endopeptidase activity:serine-type endopeptidase activity:hydrolase activity, hydrolyzing O-glycosyl compounds:transporter activity:binding:iron ion binding:ATP binding:glycogen biosynthetic process:electron transport:adenine catabolic process:DNA repair:regulation of transcription, DNA-dependent:proteolysis:transport:cation transport:electron carrier activity:aa3-type cytochrome c oxidase:ba3-type cytochrome c oxidase:caa3-type cytochrome c oxidase:cbb3-type cytochrome c oxidase:oxidoreductase activity:ATPase activity:nucleoside-triphosphatase activity:heme binding:metal ion transport:cation binding:metal ion transmembrane transporter activity:hydrogen ion transporting ATP synthase activity, rotational mechanism:proton-transporting ATPase activity, rotational mechanism:undecaprenyl-phosphate galactose phosphotransferase activity:cell division:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Oxidative phosphorylation:Oxidative phosphorylation:Purine metabolism:Purine metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Butanoate metabolism:Butanoate metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sms:sms:ade:ade:branching_enzym:branching_enzym:caa3_sub_IV:caa3_sub_IV:FtsE:FtsE:EpsB_2:EpsB_2:Signal Transduction:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Membrane Transport:Signal Transduction:Cell Motility:Metabolism:Metabolism:Environmental Information Processing:Cellular Processes:Global:Electron transport:Biosynthesis and degradation of polysaccharides:Salvage of nucleosides and nucleotides:DNA replication, recombination, and repair:Cell division:Energy metabolism:Purines, pyrimidines, nucleosides, and nucleotides:DNA metabolism:Cellular processes:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Electron transport:Biosynthesis and degradation of polysaccharides:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:DNA metabolism:DNA replication, recombination, and repair:Cellular processes:Cell division:Cellular processes and signaling:Metabolism:Poorly characterized" 49 "Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:peptidyl-prolyl cis-trans isomerase activity:cyclophilin:protein folding:FK506-sensitive peptidyl-prolyl cis-trans isomerase:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Cellular processes and signaling:Cellular processes and signaling" 50 "Phosphopantothenoylcysteine synthetase/decarboxylase:Phosphopantothenoylcysteine synthetase/decarboxylase:S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase):S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase):ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Protein-disulfide isomerase:Protein-disulfide isomerase:DNA gyrase inhibitor:DNA gyrase inhibitor:Amino acid transport and metabolism:Amino acid transport and metabolism:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:phosphopantothenate--cysteine ligase activity:phosphopantothenoylcysteine decarboxylase activity:transporter activity:regulation of transcription, DNA-dependent:transport:queuosine biosynthetic process:S-adenosylmethionine-dependent methyltransferase activity:protein disulfide oxidoreductase activity:sequence-specific DNA binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Signal transduction mechanisms:Signal transduction mechanisms:queA:queA:coaBC_dfp:coaBC_dfp:Protein synthesis:tRNA and rRNA base modification:Biosynthesis of cofactors, prosthetic groups, and carriers:Biosynthesis of cofactors, prosthetic groups, and carriers:Information storage and processing:Cellular processes and signaling:Metabolism:Protein synthesis:Pantothenate and coenzyme A:tRNA and rRNA base modification:Global:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism" 51 "tRNA and rRNA cytosine-C5-methylases:tRNA and rRNA cytosine-C5-methylases:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:FOG: TPR repeat, SEL1 subfamily:FOG: TPR repeat, SEL1 subfamily:DNA segregation ATPase FtsK/SpoIIIE and related proteins:DNA segregation ATPase FtsK/SpoIIIE and related proteins:GTPases:GTPases:Predicted ATPase:Predicted ATPase:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:DNA binding:catalytic activity:binding:ATP binding:GTP binding:regulation of transcription, DNA-dependent:cell cycle:chromosome segregation:ferrous iron transmembrane transporter activity:ferrous iron transport:nucleoside-triphosphatase activity:cell division:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Base excision repair:Base excision repair:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:GTP_HflX:GTP_HflX:tRNA_sel_U_synt:tRNA_sel_U_synt:tRNA and rRNA base modification:Unknown function:General:Information storage and processing:Cellular processes and signaling:Genetic Information Processing:Cellular processes and signaling:Information storage and processing:Unknown function:Protein synthesis:General:tRNA and rRNA base modification:Genetic Information Processing:Replication and Repair:Poorly characterized:Replication and Repair:Poorly characterized:Protein synthesis" 52 "Energy production and conversion:Energy production and conversion:Orotate phosphoribosyltransferase:Orotate phosphoribosyltransferase:Pseudouridylate synthases, 23S RNA-specific:Pseudouridylate synthases, 23S RNA-specific:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Lipoprotein signal peptidase:Lipoprotein signal peptidase:Ni,Fe-hydrogenase maturation factor:Ni,Fe-hydrogenase maturation factor:ABC-type transport system involved in cytochrome c biogenesis, permease component:ABC-type transport system involved in cytochrome c biogenesis, permease component:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:Lipoproteins:Lipoproteins:Phosphomannomutase:Phosphomannomutase:Cytochrome c biogenesis factor:Cytochrome c biogenesis factor:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted CoA-binding protein:Predicted CoA-binding protein:Polysulphide reductase:Polysulphide reductase:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:pseudouridine synthesis:DNA binding:RNA binding:catalytic activity:nicotinate-nucleotide diphosphorylase (carboxylating) activity:orotate phosphoribosyltransferase activity:pseudouridylate synthase activity:binding:carbohydrate metabolic process:pyrimidine nucleotide biosynthetic process:proteolysis:fatty acid biosynthetic process:cellular aromatic compound metabolic process:enzyme activator activity:peptidase activity:respiratory chain complex IV assembly:phosphoglucosamine mutase activity:signal peptidase II activity:nucleoside metabolic process:protein secretion:NAD biosynthetic process:RNA modification:pseudouridine synthase activity:heme transporter activity:heme transport:hydrolase activity:hydro-lyase activity:cytochrome complex assembly:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Fatty acid biosynthesis:Fatty acid biosynthesis:Pyrimidine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Vitamin B6 metabolism:Vitamin B6 metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Protein export:Protein export:General function prediction only:General function prediction only:Function unknown:Function unknown:hydrog_prot:hydrog_prot:lspA:lspA:TIGR00282:TIGR00282:pyrE:pyrE:rlpA:rlpA:glmM:glmM:fabZ:fabZ:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Pyrimidine ribonucleotide biosynthesis:Protein fate:Protein and peptide secretion and trafficking:Unknown function:Enzymes of unknown specificity:Cell envelope:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Pyrimidine ribonucleotide biosynthesis:Biosynthesis:Protein and peptide secretion and trafficking:Enzymes of unknown specificity:Other:Central intermediary metabolism:Fatty acid and phospholipid metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Protein fate:Unknown function:Cell envelope:Amino sugars:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Amino sugars:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides" 53 "Energy production and conversion:Energy production and conversion:6-phosphofructokinase:6-phosphofructokinase:Uncharacterized flavoproteins:Uncharacterized flavoproteins:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Transcriptional regulator:Transcriptional regulator:Permeases of the drug/metabolite transporter (DMT) superfamily:Permeases of the drug/metabolite transporter (DMT) superfamily:Predicted permeases:Predicted permeases:FOG: CheY-like receiver:FOG: CheY-like receiver:Cell wall-associated hydrolases (invasion-associated proteins):Cell wall-associated hydrolases (invasion-associated proteins):Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:MinD superfamily P-loop ATPase containing an inserted ferredoxin domain:MinD superfamily P-loop ATPase containing an inserted ferredoxin domain:ABC-type Fe3+ transport system, permease component:ABC-type Fe3+ transport system, permease component:Lysine efflux permease:Lysine efflux permease:Predicted N-acetylglucosaminyl transferase:Predicted N-acetylglucosaminyl transferase:Heat shock protein:Heat shock protein:Predicted membrane protein:Predicted membrane protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:structural constituent of ribosome:6-phosphofructokinase activity:transporter activity:binding:protein binding:ATP binding:glycolysis:electron transport:regulation of transcription, DNA-dependent:translation:transport:amino acid transport:chemotaxis:tRNA processing:pyruvate, water dikinase activity:electron carrier activity:cobalamin biosynthetic process:FMN binding:phosphorylation:oxidoreductase activity:sulfurtransferase activity:hydrolase activity:cobyrinic acid a,c-diamide synthase activity:iron-sulfur cluster binding:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Fructose and mannose metabolism:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:argP:argP:selenium_YedF:selenium_YedF:Poorly characterized:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Carbohydrate Metabolism:Cellular processes and signaling:Information storage and processing:DNA interactions:Small molecule interactions:Regulatory functions:Cell Motility:Cellular Processes:Signal Transduction:Regulatory functions:DNA interactions:Small molecule interactions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Carbohydrate Metabolism:Metabolism" 54 "Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Prephenate dehydratase:Prephenate dehydratase:5-enolpyruvylshikimate-3-phosphate synthase:5-enolpyruvylshikimate-3-phosphate synthase:Tryptophan synthase beta chain:Tryptophan synthase beta chain:Indole-3-glycerol phosphate synthase:Indole-3-glycerol phosphate synthase:Phosphoribosylanthranilate isomerase:Phosphoribosylanthranilate isomerase:Anthranilate/para-aminobenzoate synthases component I:Anthranilate/para-aminobenzoate synthases component I:Tryptophan synthase alpha chain:Tryptophan synthase alpha chain:Leucyl aminopeptidase:Leucyl aminopeptidase:Prephenate dehydrogenase:Prephenate dehydrogenase:Lipoate synthase:Lipoate synthase:Glycosyltransferases involved in cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Anthranilate/para-aminobenzoate synthases component II:Anthranilate/para-aminobenzoate synthases component II:Anthranilate phosphoribosyltransferase:Anthranilate phosphoribosyltransferase:Membrane-fusion protein:Membrane-fusion protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:HD-GYP domain:HD-GYP domain:ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain:ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain:Uncharacterized metal-binding protein:Uncharacterized metal-binding protein:Site-specific recombinase XerD:Site-specific recombinase XerD:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):tryptophan biosynthetic process:DNA binding:sequence-specific DNA binding transcription factor activity:3-phosphoshikimate 1-carboxyvinyltransferase activity:anthranilate phosphoribosyltransferase activity:anthranilate synthase activity:chorismate mutase activity:leucyl aminopeptidase activity:aspartic-type endopeptidase activity:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity:indole-3-glycerol-phosphate synthase activity:monooxygenase activity:phosphoribosylanthranilate isomerase activity:prephenate dehydratase activity:prephenate dehydrogenase (NADP+) activity:tryptophan synthase activity:signal transducer activity:iron ion transmembrane transporter activity:iron ion binding:ATP binding:glucose metabolic process:glycolysis:electron transport:DNA recombination:regulation of transcription, DNA-dependent:proteolysis:glutamine metabolic process:tryptophan metabolic process:tyrosine biosynthetic process:transport:anion transport:iron ion transport:signal transduction:transcription factor binding:metabolic process:peptidase activity:protein transporter activity:prephenate dehydrogenase activity:protein-glutamate methylesterase activity:electron carrier activity:biosynthetic process:L-phenylalanine biosynthetic process:lipoate biosynthetic process:cobalamin biosynthetic process:protein secretion:protein transport:DNA integration:amino acid binding:ligase activity:lipoate synthase activity:nucleoside-triphosphatase activity:glyceraldehyde-3-phosphate metabolic process:manganese ion binding:pyridoxal phosphate binding:cobyrinic acid a,c-diamide synthase activity:ATPase activity, coupled to transmembrane movement of substances:4-amino-4-deoxychorismate synthase activity:cyclohexadienyl dehydrogenase activity:NAD binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Novobiocin biosynthesis:Glutathione metabolism:Glutathione metabolism:Lipoic acid metabolism:Lipoic acid metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:trpA:trpA:trpB:trpB:lipA:lipA:trpG_papA:trpG_papA:trpD:trpD:GAPDH-I:GAPDH-I:type_I_hlyD:type_I_hlyD:type_I_sec_LssB:type_I_sec_LssB:Defense mechanisms:Defense mechanisms:Metabolism of Cofactors and Vitamins:Pathogenesis:Energy metabolism:Glycolysis/gluconeogenesis:Regulatory functions:Small molecule interactions:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Pathogenesis:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Lipoate:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Other Amino Acids:Metabolism:Amino Acid Metabolism:Carbohydrate Metabolism:Metabolism:Biosynthesis of Other Secondary Metabolites:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Carbohydrate Metabolism:Protein and peptide secretion and trafficking:Metabolism:Cellular processes and signaling:Information storage and processing:Global:Glycolysis/gluconeogenesis:Small molecule interactions:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino acid biosynthesis:Cellular processes:Protein fate:Regulatory functions:Energy metabolism:Lipoate:Aromatic amino acid family:Global:Metabolism:Biosynthesis of Other Secondary Metabolites" 55 "Acetyltransferase (isoleucine patch superfamily):Acetyltransferase (isoleucine patch superfamily):Predicted rRNA methylase (SpoU class):Predicted rRNA methylase (SpoU class):Folate-dependent phosphoribosylglycinamide formyltransferase PurN:Folate-dependent phosphoribosylglycinamide formyltransferase PurN:Uncharacterized conserved protein:Uncharacterized conserved protein:Orotate phosphoribosyltransferase:Orotate phosphoribosyltransferase:Glycosyltransferases involved in cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:Lipoproteins:Lipoproteins:Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain:Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain:Uroporphyrinogen-III synthase:Uroporphyrinogen-III synthase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:DNA gyrase inhibitor:DNA gyrase inhibitor:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:orotate phosphoribosyltransferase activity:phosphoribosylglycinamide formyltransferase activity:uroporphyrin-III C-methyltransferase activity:uroporphyrinogen-III synthase activity:ATP binding:'de novo' IMP biosynthetic process:pyrimidine nucleotide biosynthetic process:regulation of transcription, DNA-dependent:RNA processing:translation:proteolysis:porphyrin-containing compound biosynthetic process:RNA methyltransferase activity:peptidase activity:biosynthetic process:nucleoside metabolic process:RNA modification:transferase activity:transferase activity, transferring acyl groups:peptidyl-histidine phosphorylation:sequence-specific DNA binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:One carbon pool by folate:One carbon pool by folate:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:pyrE:pyrE:rlpA:rlpA:PurN:PurN:cobA_cysG_Cterm:cobA_cysG_Cterm:Purine ribonucleotide biosynthesis:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Metabolism:Metabolism:Global:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:Small molecule interactions:Heme, porphyrin, and cobalamin:Other:Purines, pyrimidines, nucleosides, and nucleotides:Regulatory functions:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 56 "Energy production and conversion:Energy production and conversion:tRNA-dihydrouridine synthase:tRNA-dihydrouridine synthase:Predicted GTPase:Predicted GTPase:Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:Ribosomal protein S1:Ribosomal protein S1:Thiamine monophosphate kinase:Thiamine monophosphate kinase:Periplasmic serine proteases (ClpP class):Periplasmic serine proteases (ClpP class):Fe-S oxidoreductases:Fe-S oxidoreductases:3-dehydroquinate dehydratase II:3-dehydroquinate dehydratase II:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:Predicted permeases:Predicted permeases:Predicted thioesterase:Predicted thioesterase:Nicotinic acid mononucleotide adenylyltransferase:Nicotinic acid mononucleotide adenylyltransferase:4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase:4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase:Amino acid transport and metabolism:Amino acid transport and metabolism:nucleotide binding:nucleic acid binding:RNA binding:structural constituent of ribosome:translation elongation factor activity:catalytic activity:3-dehydroquinate dehydratase activity:GTPase activity:nicotinate-nucleotide adenylyltransferase activity:transporter activity:ATP binding:GTP binding:translation:translational elongation:proteolysis:transport:tRNA processing:metabolic process:endopeptidase Clp activity:protein-synthesizing GTPase activity:thiamine-phosphate kinase activity:aromatic amino acid family biosynthetic process:thiamine biosynthetic process:NAD biosynthetic process:ferrous iron transmembrane transporter activity:ferrous iron transport:terpenoid biosynthetic process:phosphorylation:oxidoreductase activity:hydrolase activity:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Thiamine metabolism:Thiamine metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Ribosome:Ribosome:General function prediction only:General function prediction only:Function unknown:Function unknown:efp:efp:TIGR00051:TIGR00051:ispE:ispE:TIGR00482:TIGR00482:SppA_dom:SppA_dom:rpsA:rpsA:thiL:thiL:HEQRo_perm_3TM:HEQRo_perm_3TM:GTPase_YsxC:GTPase_YsxC:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Amino acids, peptides and amines:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Thiamine:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Other:Global:Ribosomal proteins: synthesis and modification:Translation factors:Degradation of proteins, peptides, and glycopeptides:Amino acids, peptides and amines:General:Other:Thiamine:Pyridine nucleotides:Protein synthesis:Protein fate:Transport and binding proteins:Unknown function:Biosynthesis of cofactors, prosthetic groups, and carriers:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein synthesis:Other:Ribosomal proteins: synthesis and modification:Translation factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins" 57 "Energy production and conversion:Energy production and conversion:Mg-dependent DNase:Mg-dependent DNase:Delta-aminolevulinic acid dehydratase:Delta-aminolevulinic acid dehydratase:DNA mismatch repair enzyme (predicted ATPase):DNA mismatch repair enzyme (predicted ATPase):ATP-dependent Lon protease, bacterial type:ATP-dependent Lon protease, bacterial type:Acetylglutamate kinase:Acetylglutamate kinase:Predicted permeases:Predicted permeases:Ribose 5-phosphate isomerase RpiB:Ribose 5-phosphate isomerase RpiB:Predicted sugar phosphate isomerase involved in capsule formation:Predicted sugar phosphate isomerase involved in capsule formation:Collagenase and related proteases:Collagenase and related proteases:Fe-S oxidoreductase:Fe-S oxidoreductase:Arginine decarboxylase (spermidine biosynthesis):Arginine decarboxylase (spermidine biosynthesis):ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Inactive homolog of metal-dependent proteases, putative molecular chaperone:Inactive homolog of metal-dependent proteases, putative molecular chaperone:Histidinol phosphatase and related hydrolases of the PHP family:Histidinol phosphatase and related hydrolases of the PHP family:Acyl-CoA hydrolase:Acyl-CoA hydrolase:Transcriptional regulators:Transcriptional regulators:DNA repair proteins:DNA repair proteins:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA-directed DNA polymerase activity:acetylglutamate kinase activity:ATP-dependent peptidase activity:porphobilinogen synthase activity:ribose-5-phosphate isomerase activity:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity:ATP binding:sugar binding:carbohydrate metabolic process:pentose-phosphate shunt:electron transport:DNA replication:DNA repair:nucleotide-excision repair:mismatch repair:regulation of transcription, DNA-dependent:proteolysis:ATP-dependent proteolysis:arginine biosynthetic process:arginine catabolic process:tRNA processing:metabolic process:peptidase activity:spermidine biosynthetic process:O-sialoglycoprotein endopeptidase activity:arginine decarboxylase activity:endopeptidase La activity:thiamine biosynthetic process:cobalamin biosynthetic process:excinuclease ABC activity:oxidoreductase activity:nucleoside-triphosphatase activity:arabinose-5-phosphate isomerase activity:heme binding:mismatched DNA binding:tetrapyrrole biosynthetic process:cobyrinic acid a,c-diamide synthase activity:sequence-specific DNA binding:metal ion binding:transition metal ion binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Pentose phosphate pathway:Pentose phosphate pathway:Lysine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Limonene and pinene degradation:Limonene and pinene degradation:Biosynthesis of unsaturated fatty acids:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Nucleotide excision repair:Nucleotide excision repair:Mismatch repair:Mismatch repair:General function prediction only:General function prediction only:TIGR00010:TIGR00010:uvrC:uvrC:kpsF:kpsF:mutl:mutl:radc:radc:rpiB_lacA_lacB:rpiB_lacA_lacB:argB:argB:lon:lon:speA:speA:bact_YeaZ:bact_YeaZ:TIGR03905_4_Cys:TIGR03905_4_Cys:sam_1_link_chp:sam_1_link_chp:Cellular processes and signaling:Metabolism:Poorly characterized:Replication and Repair:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Energy metabolism:Central intermediary metabolism:DNA metabolism:Protein fate:Unknown function:Amino acid biosynthesis:Glutamate family:General:Enzymes of unknown specificity:Degradation of proteins, peptides, and glycopeptides:DNA replication, recombination, and repair:Sugars:Polyamine biosynthesis:Global:Genetic Information Processing:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Replication and Repair:Global:Metabolism:Central intermediary metabolism:Polyamine biosynthesis:Energy metabolism:Sugars:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Degradation of proteins, peptides, and glycopeptides:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Glutamate family:Information storage and processing" 58 "Uncharacterized homolog of phage Mu protein gp47:Uncharacterized homolog of phage Mu protein gp47:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Mu-like prophage DNA circulation protein:Mu-like prophage DNA circulation protein:Mu-like prophage protein gp46:Mu-like prophage protein gp46:Mu-like prophage protein gp45:Mu-like prophage protein gp45:Mu-like prophage tail sheath protein gpL:Mu-like prophage tail sheath protein gpL:Bacteriophage capsid protein:Bacteriophage capsid protein:DNA binding:General function prediction only:General function prediction only:Function unknown:Function unknown:portal_lambda:portal_lambda:phage_P2_V:phage_P2_V:Mobile and extrachromosomal element functions:Poorly characterized:Mobile and extrachromosomal element functions:Prophage functions:Poorly characterized:Prophage functions" 59 "Periplasmic serine proteases (ClpP class):Periplasmic serine proteases (ClpP class):Predicted phosphoglycerate mutase, AP superfamily:Predicted phosphoglycerate mutase, AP superfamily:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Flp pilus assembly protein, ATPase CpaF:Flp pilus assembly protein, ATPase CpaF:Flp pilus assembly protein TadD, contains TPR repeats:Flp pilus assembly protein TadD, contains TPR repeats:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):binding:ATP binding:GTP binding:regulation of transcription, DNA-dependent:proteolysis:transport:microtubule-based process:peptidase activity:peptidyl-histidine phosphorylation:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity:metal ion binding:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Cellular processes and signaling:Regulatory functions:Small molecule interactions:Regulatory functions:Cellular processes and signaling:Metabolism:Small molecule interactions" 60 "Energy production and conversion:Energy production and conversion:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Glucan phosphorylase:Glucan phosphorylase:Glutamine synthetase:Glutamine synthetase:Membrane protease subunits, stomatin/prohibitin homologs:Membrane protease subunits, stomatin/prohibitin homologs:Uncharacterized flavoproteins:Uncharacterized flavoproteins:Translation elongation factors (GTPases):Translation elongation factors (GTPases):Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Cytosine/adenosine deaminases:Cytosine/adenosine deaminases:Putative intracellular protease/amidase:Putative intracellular protease/amidase:Glutaredoxin and related proteins:Glutaredoxin and related proteins:UDP-glucose pyrophosphorylase:UDP-glucose pyrophosphorylase:Rubrerythrin:Rubrerythrin:Predicted Rossmann fold nucleotide-binding protein:Predicted Rossmann fold nucleotide-binding protein:Rubredoxin:Rubredoxin:Desulfoferrodoxin:Desulfoferrodoxin:Bacterioferritin (cytochrome b1):Bacterioferritin (cytochrome b1):FOG: GAF domain:FOG: GAF domain:Dihydroxyacetone kinase:Dihydroxyacetone kinase:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:magnesium ion binding:GTPase activity:UTP:glucose-1-phosphate uridylyltransferase activity:acetolactate synthase activity:cytosine deaminase activity:glutamate-ammonia ligase activity:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity:glycerone kinase activity:iron ion binding:GTP binding:carbohydrate metabolic process:glucose metabolic process:UDP-glucose metabolic process:glycerol metabolic process:glycolysis:electron transport:translation:glutamine biosynthetic process:Mo-molybdopterin cofactor biosynthetic process:iron ion transport:cellular iron ion homeostasis:response to stress:glycogen phosphorylase activity:ferric iron binding:zinc ion binding:protein-synthesizing GTPase activity:electron carrier activity:biosynthetic process:nitrogen fixation:FMN binding:protein disulfide oxidoreductase activity:oxidoreductase activity:hydrolase activity:hydrolase activity, acting on glycosyl bonds:glyceraldehyde-3-phosphate metabolic process:pyridoxal phosphate binding:thiamine pyrophosphate binding:cell redox homeostasis:metal ion binding:transition metal ion binding:superoxide reductase activity:NAD binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Pentose and glucuronate interconversions:Galactose metabolism:Galactose metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glycerolipid metabolism:Glycerolipid metabolism:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:desulf_FeS4:desulf_FeS4:TIGR00730:TIGR00730:galU:galU:PfpI:PfpI:GAPDH-I:GAPDH-I:more_P_ylases:more_P_ylases:dhaK1:dhaK1:Glycolysis/gluconeogenesis:Protein fate:Degradation of proteins, peptides, and glycopeptides:Hypothetical proteins:Conserved:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Carbohydrate Metabolism:Information storage and processing:Cell envelope:Hypothetical proteins:Protein fate:Energy metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Conserved:Degradation of proteins, peptides, and glycopeptides:Glycolysis/gluconeogenesis:Electron transport:Global:Environmental Information Processing:Metabolism:Metabolism:Signal Transduction:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Global:Metabolism:Signal Transduction:Energy metabolism:Electron transport" 61 "Energy production and conversion:Energy production and conversion:Formate hydrogenlyase subunit 4:Formate hydrogenlyase subunit 4:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:ABC-type antimicrobial peptide transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Multidrug resistance efflux pump:Multidrug resistance efflux pump:Arabinose efflux permease:Arabinose efflux permease:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:transporter activity:binding:ATP binding:electron transport:mitochondrial electron transport, NADH to ubiquinone:regulation of transcription, DNA-dependent:transport:transcription factor binding:NADH dehydrogenase (ubiquinone) activity:protein transporter activity:cobalamin biosynthetic process:protein secretion:pathogenesis:ATPase activity:nucleoside-triphosphatase activity:cobyrinic acid a,c-diamide synthase activity:ATP synthesis coupled electron transport:regulation of protein secretion:iron-sulfur cluster binding:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Methane metabolism:Methane metabolism:Defense mechanisms:Defense mechanisms:Cellular processes and signaling:Energy Metabolism:Metabolism:Metabolism:Cellular processes and signaling:Energy Metabolism:Metabolism:Metabolism" 62 "Energy production and conversion:Energy production and conversion:Gamma-glutamyl phosphate reductase:Gamma-glutamyl phosphate reductase:Putative translation initiation inhibitor, yjgF family:Putative translation initiation inhibitor, yjgF family:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Predicted membrane protein:Predicted membrane protein:Hydrogenase maturation factor:Hydrogenase maturation factor:Ketopantoate hydroxymethyltransferase:Ketopantoate hydroxymethyltransferase:Uncharacterized conserved protein:Uncharacterized conserved protein:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:UDP-glucose 4-epimerase:UDP-glucose 4-epimerase:Flagellin and related hook-associated proteins:Flagellin and related hook-associated proteins:Predicted dioxygenase:Predicted dioxygenase:Aspartyl aminopeptidase:Aspartyl aminopeptidase:Coenzyme F390 synthetase:Coenzyme F390 synthetase:Uncharacterized conserved protein:Uncharacterized conserved protein:Selenocysteine synthase [seryl-tRNASer selenium transferase]:Selenocysteine synthase [seryl-tRNASer selenium transferase]:Sialic acid synthase:Sialic acid synthase:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):selenocysteine incorporation:ciliary or flagellar motility:catalytic activity:3-methyl-2-oxobutanoate hydroxymethyltransferase activity:UDP-glucose 4-epimerase activity:L-seryl-tRNASec selenium transferase activity:aminopeptidase I activity:ferredoxin-NADP+ reductase activity:glutamate-5-semialdehyde dehydrogenase activity:glycerol-3-phosphate O-acyltransferase activity:signal transducer activity:structural molecule activity:protein binding:ATP binding:carbohydrate metabolic process:electron transport:pyrimidine nucleotide biosynthetic process:regulation of transcription, DNA-dependent:proteolysis:proline biosynthetic process:signal transduction:tRNA processing:metabolic process:dTDP-4-dehydrorhamnose reductase activity:dihydrodipicolinate synthase activity:cyclic nucleotide biosynthetic process:NADPH-adrenodoxin reductase activity:pantothenate biosynthetic process:carbohydrate biosynthetic process:selenocysteine biosynthetic process:oxidoreductase activity:transcription repressor activity:transferase activity:sulfurtransferase activity:phosphorus-oxygen lyase activity:diaminopimelate biosynthetic process:pyridoxal phosphate binding:intracellular signal transduction:aspartyl aminopeptidase activity:cellular metabolic process:extracellular polysaccharide biosynthetic process:negative regulation of transcription, DNA-dependent:metal ion binding:N-acylneuraminate-9-phosphate synthase activity:phenylacetate-CoA ligase activity:N-acetylneuraminate synthase activity:flavin adenine dinucleotide binding:NADP binding:coenzyme binding:iron-sulfur cluster binding:2 iron, 2 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Galactose metabolism:Galactose metabolism:Lysine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Selenocompound metabolism:Selenocompound metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glycerolipid metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00004:TIGR00004:TIGR00023:TIGR00023:hypD:hypD:TIGR00149_YbjQ:TIGR00149_YbjQ:panB:panB:sensory_box:sensory_box:proA:proA:TIGR00423:TIGR00423:selA:selA:dapA:dapA:selenium_YedF:selenium_YedF:FlgM_jcvi:FlgM_jcvi:Protein fate:Protein modification and repair:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aspartate family:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cell Motility:Signal Transduction:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:Biosynthesis:Small molecule interactions:Degradation of RNA:tRNA aminoacylation:Protein modification and repair:Conserved:Enzymes of unknown specificity:Aspartate family:Glutamate family:Pantothenate and coenzyme A:Fatty acid and phospholipid metabolism:Regulatory functions:Transcription:Protein synthesis:Protein fate:Hypothetical proteins:Unknown function:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Translation:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:Transcription:Degradation of RNA:Protein synthesis:tRNA aminoacylation" 63 "Energy production and conversion:Energy production and conversion:Predicted sugar kinase:Predicted sugar kinase:Cysteinyl-tRNA synthetase:Cysteinyl-tRNA synthetase:Fe-S oxidoreductase:Fe-S oxidoreductase:Putative translation initiation inhibitor, yjgF family:Putative translation initiation inhibitor, yjgF family:RecA/RadA recombinase:RecA/RadA recombinase:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:D-alanine-D-alanine ligase and related ATP-grasp enzymes:D-alanine-D-alanine ligase and related ATP-grasp enzymes:Transcriptional regulators:Transcriptional regulators:Protein-disulfide isomerase:Protein-disulfide isomerase:Transcriptional regulators:Transcriptional regulators:Preprotein translocase subunit YajC:Preprotein translocase subunit YajC:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Outer membrane protein:Outer membrane protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:fatty-acyl-CoA binding:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:DNA binding:damaged DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:NAD+ kinase activity:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity:cysteine-tRNA ligase activity:calcium-transporting ATPase activity:protein binding:ATP binding:carbohydrate metabolic process:electron transport:DNA metabolic process:DNA repair:DNA recombination:regulation of transcription, DNA-dependent:cysteinyl-tRNA aminoacylation:chemotaxis:DNA-dependent ATPase activity:transcription factor binding:metabolic process:D-alanine-D-alanine ligase activity:electron carrier activity:peptidoglycan biosynthetic process:protein disulfide oxidoreductase activity:hydrolase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:nucleoside-triphosphatase activity:regulation of fatty acid metabolic process:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:D-Alanine metabolism:D-Alanine metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00004:TIGR00004:cysS:cysS:yajC:yajC:D_ala_D_alaTIGR:D_ala_D_alaTIGR:tigrfam_recA:tigrfam_recA:TIGR03905_4_Cys:TIGR03905_4_Cys:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Unknown function:General:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Signal Transduction:Membrane Transport:Replication and Repair:Folding Sorting and Degradation:Translation:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Degradation of RNA:DNA replication, recombination, and repair:tRNA aminoacylation:Protein and peptide secretion and trafficking:General:Biosynthesis and degradation of murein sacculus and peptidoglycan:DNA metabolism:Transcription:Protein synthesis:Protein fate:Unknown function:Cell envelope:Global:Cellular Processes:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Cell Motility:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Protein synthesis" 64 "Nucleoside diphosphate kinase:Nucleoside diphosphate kinase:Glutamine amidotransferase:Glutamine amidotransferase:Pseudouridine synthase:Pseudouridine synthase:Fructose-1,6-bisphosphatase:Fructose-1,6-bisphosphatase:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Ribosomal protein L35:Ribosomal protein L35:(acyl-carrier-protein) S-malonyltransferase:(acyl-carrier-protein) S-malonyltransferase:Pyrroline-5-carboxylate reductase:Pyrroline-5-carboxylate reductase:Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division:Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division:GMP synthase, PP-ATPase domain/subunit:GMP synthase, PP-ATPase domain/subunit:DNA polymerase sliding clamp subunit (PCNA homolog):DNA polymerase sliding clamp subunit (PCNA homolog):Transcription elongation factor:Transcription elongation factor:Predicted Fe-S-cluster redox enzyme:Predicted Fe-S-cluster redox enzyme:Acetyl-CoA carboxylase alpha subunit:Acetyl-CoA carboxylase alpha subunit:Sec-independent protein secretion pathway components:Sec-independent protein secretion pathway components:Predicted RNA-binding protein:Predicted RNA-binding protein:Phosphotransferase system, HPr-related proteins:Phosphotransferase system, HPr-related proteins:Long-chain fatty acid transport protein:Long-chain fatty acid transport protein:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:histidine biosynthetic process:nucleic acid binding:DNA binding:transcription elongation regulator activity:RNA binding:structural constituent of ribosome:catalytic activity:DNA-directed DNA polymerase activity:DNA topoisomerase (ATP-hydrolyzing) activity:GMP synthase activity:GMP synthase (glutamine-hydrolyzing) activity:acetyl-CoA carboxylase activity:asparagine synthase (glutamine-hydrolyzing) activity:[acyl-carrier-protein] S-malonyltransferase activity:nucleoside diphosphate kinase activity:phosphogluconate dehydrogenase (decarboxylating) activity:pseudouridylate synthase activity:pyrroline-5-carboxylate reductase activity:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity:sugar:hydrogen symporter activity:ATP binding:carbohydrate metabolic process:gluconeogenesis:pentose-phosphate shunt:electron transport:GMP biosynthetic process:GTP biosynthetic process:UTP biosynthetic process:CTP biosynthetic process:DNA replication:DNA topological change:regulation of transcription, DNA-dependent:tRNA modification:translation:asparagine biosynthetic process:glutamine metabolic process:proline biosynthetic process:fatty acid biosynthetic process:cell cycle:tRNA processing:3'-5' exonuclease activity:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity:protein secretion:phosphoenolpyruvate-dependent sugar phosphotransferase system:pseudouridine synthase activity:protein transport:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:transferase activity:transferase activity, transferring pentosyl groups:tRNA pseudouridine synthesis:fructose 1,6-bisphosphate 1-phosphatase activity:iron-sulfur cluster binding:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Fructose and mannose metabolism:Fructose and mannose metabolism:Fatty acid biosynthesis:Fatty acid biosynthesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Histidine metabolism:Histidine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Phosphotransferase system (PTS):Phosphotransferase system (PTS):Ribosome:Ribosome:DNA replication:DNA replication:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:rpmI_bact:rpmI_bact:TIGR00048:TIGR00048:proC:proC:fabD:fabD:TruB:TruB:dnan:dnan:guaA_Cterm:guaA_Cterm:PTS_HPr_family:PTS_HPr_family:gyrB:gyrB:tatB:tatB:greA:greA:IMP_synth_hisH:IMP_synth_hisH:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Transcription:Transcription factors:Protein synthesis:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Amino acid biosynthesis:Glutamate family:Histidine family:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Energy Metabolism:Carbohydrate Metabolism:Purine ribonucleotide biosynthesis:Protein and peptide secretion and trafficking:Glutamate family:Histidine family:PTS:Fatty acid and phospholipid metabolism:Purines, pyrimidines, nucleosides, and nucleotides:DNA metabolism:Transcription:Protein synthesis:Protein fate:Amino acid biosynthesis:Signal transduction:Ribosomal proteins: synthesis and modification:Transcription factors:DNA replication, recombination, and repair:Purine ribonucleotide biosynthesis:Biosynthesis:Global:Environmental Information Processing:Genetic Information Processing:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Metabolism:Metabolism:Membrane Transport:Replication and Repair:Energy Metabolism:Lipid Metabolism:Folding Sorting and Degradation:Nucleotide Metabolism:Translation:Amino Acid Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:tRNA and rRNA base modification:DNA metabolism:DNA replication, recombination, and repair" 65 "Imidazoleglycerol-phosphate synthase:Imidazoleglycerol-phosphate synthase:Predicted EndoIII-related endonuclease:Predicted EndoIII-related endonuclease:Integral membrane protein possibly involved in chromosome condensation:Integral membrane protein possibly involved in chromosome condensation:Histidinol phosphatase and related phosphatases:Histidinol phosphatase and related phosphatases:Glycosyltransferase:Glycosyltransferase:Membrane GTPase LepA:Membrane GTPase LepA:Leucyl-tRNA synthetase:Leucyl-tRNA synthetase:Sugar kinases, ribokinase family:Sugar kinases, ribokinase family:Uridylate kinase:Uridylate kinase:Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:CDP-diglyceride synthetase:CDP-diglyceride synthetase:DNA polymerase III, alpha subunit:DNA polymerase III, alpha subunit:6-pyruvoyl-tetrahydropterin synthase:6-pyruvoyl-tetrahydropterin synthase:Transcription termination factor:Transcription termination factor:Holliday junction resolvasome, endonuclease subunit:Holliday junction resolvasome, endonuclease subunit:Predicted UDP-glucose 6-dehydrogenase:Predicted UDP-glucose 6-dehydrogenase:Threonine aldolase:Threonine aldolase:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Predicted exonuclease:Predicted exonuclease:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:histidine biosynthetic process:imidazoleglycerol-phosphate synthase activity:nucleic acid binding:DNA binding:transcription termination factor activity:RNA binding:catalytic activity:6-pyruvoyltetrahydropterin synthase activity:DNA-directed DNA polymerase activity:DNA-(apurinic or apyrimidinic site) lyase activity:GTPase activity:UDP-glucose 6-dehydrogenase activity:adenosine kinase activity:histidinol-phosphatase activity:endonuclease activity:phosphatidate cytidylyltransferase activity:threonine aldolase activity:leucine-tRNA ligase activity:ATP binding:GTP binding:electron transport:pyrimidine nucleotide biosynthetic process:DNA replication:DNA repair:base-excision repair:DNA recombination:transcription termination, DNA-dependent:regulation of transcription, DNA-dependent:translation:leucyl-tRNA aminoacylation:cellular amino acid metabolic process:transport:metabolic process:zinc ion binding:3'-5' exonuclease activity:protein-synthesizing GTPase activity:cellular amino acid biosynthetic process:phospholipid biosynthetic process:crossover junction endodeoxyribonuclease activity:uridylate kinase activity:biosynthetic process:pilus assembly:protein secretion:nutrient import:lipoate-protein ligase activity:pyridoxal phosphate binding:sequence-specific DNA binding:NAD binding:iron-sulfur cluster binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Pentose and glucuronate interconversions:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Ascorbate and aldarate metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Histidine metabolism:Histidine metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Folate biosynthesis:Folate biosynthesis:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:DNA replication:DNA replication:Base excision repair:Base excision repair:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:ruvC:ruvC:small_GTP:small_GTP:HDIG:HDIG:leuS_bact:leuS_bact:crcB:crcB:polc:polc:hisF:hisF:nth:nth:Histidinol-ppas:Histidinol-ppas:nusB:nusB:pyrH_bact:pyrH_bact:C4_traR_proteo:C4_traR_proteo:IV_pilus_PilQ:IV_pilus_PilQ:NDP-sugDHase:NDP-sugDHase:queuosine_QueD:queuosine_QueD:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Global:Nucleotide and nucleoside interconversions:DNA replication, recombination, and repair:Transcription factors:tRNA aminoacylation:tRNA and rRNA base modification:Prophage functions:General:Histidine family:Surface structures:Purines, pyrimidines, nucleosides, and nucleotides:DNA metabolism:Transcription:Protein synthesis:Mobile and extrachromosomal element functions:Unknown function:Amino acid biosynthesis:Cell envelope:Metabolism:Replication and Repair:Translation:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Mobile and extrachromosomal element functions:Prophage functions:Unknown function:General:Amino acid biosynthesis:Histidine family:Cell envelope:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Genetic Information Processing" 66 "Energy production and conversion:Energy production and conversion:Excinuclease ATPase subunit:Excinuclease ATPase subunit:Thiamine monophosphate synthase:Thiamine monophosphate synthase:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Acylphosphatases:Acylphosphatases:Uncharacterized conserved protein:Uncharacterized conserved protein:Hydroxyethylthiazole kinase, sugar kinase family:Hydroxyethylthiazole kinase, sugar kinase family:FOG: GGDEF domain:FOG: GGDEF domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Signal transduction histidine kinase:Signal transduction histidine kinase:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:acylphosphatase activity:hydroxyethylthiazole kinase activity:thiamine-phosphate diphosphorylase activity:ATP binding:electron transport:pyrimidine nucleotide biosynthetic process:nucleotide-excision repair:regulation of transcription, DNA-dependent:protein folding:response to stress:transcription factor binding:metabolic process:cyclic nucleotide biosynthetic process:thiamine biosynthetic process:excinuclease ABC activity:oxidoreductase activity:phosphorus-oxygen lyase activity:ATPase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:heat shock protein binding:phosphopantetheine binding:intracellular signal transduction:flavin adenine dinucleotide binding:unfolded protein binding:2 iron, 2 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Pyruvate metabolism:Pyruvate metabolism:Thiamine metabolism:Thiamine metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Nucleotide excision repair:Nucleotide excision repair:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:GGDEF:GGDEF:uvra:uvra:thiE:thiE:thiM:thiM:Genetic Information Processing:Replication and Repair:Information storage and processing:Environmental Information Processing:Signal Transduction:Signal transduction:Global:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:DNA metabolism:Regulatory functions:Other:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Thiamine:DNA replication, recombination, and repair:Small molecule interactions:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Poorly characterized:Replication and Repair:Metabolism of Cofactors and Vitamins:Carbohydrate Metabolism:Signal Transduction:Metabolism:Carbohydrate Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Cellular processes and signaling" 67 "Energy production and conversion:Energy production and conversion:EMAP domain:EMAP domain:Anaerobic dehydrogenases, typically selenocysteine-containing:Anaerobic dehydrogenases, typically selenocysteine-containing:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:tRNA binding:methionine-tRNA ligase activity:ATP binding:electron transport:protein transporter activity:formate dehydrogenase (NAD+) activity:pyruvate, water dikinase activity:protein transport:phosphorylation:molybdenum ion binding:cellular respiration:Pyruvate metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:formate-DH-alph:formate-DH-alph:chap_CsaA:chap_CsaA:CxxC_CxxC_SSSS:CxxC_CxxC_SSSS:Carbohydrate Metabolism:Regulatory functions:Energy metabolism:Energy Metabolism:Protein and peptide secretion and trafficking:Global:Metabolism:DNA interactions:Electron transport:Global:Poorly characterized:Protein fate:Energy metabolism:Electron transport:Regulatory functions:DNA interactions:Protein fate:Protein and peptide secretion and trafficking:Metabolism:Poorly characterized:Metabolism:Metabolism:Energy Metabolism:Carbohydrate Metabolism:Metabolism:Metabolism" 68 "Energy production and conversion:Energy production and conversion:NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases:NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases:ABC-type phosphate transport system, permease component:ABC-type phosphate transport system, permease component:Signal transduction histidine kinase:Signal transduction histidine kinase:Formate hydrogenlyase subunit 4:Formate hydrogenlyase subunit 4:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:Membrane-fusion protein:Membrane-fusion protein:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Acyl-CoA synthetase (NDP forming):Acyl-CoA synthetase (NDP forming):ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Flagellar motor protein:Flagellar motor protein:L-serine deaminase:L-serine deaminase:Cobalamin biosynthesis protein CbiD:Cobalamin biosynthesis protein CbiD:Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain:Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain:Predicted phosphoesterases, related to the Icc protein:Predicted phosphoesterases, related to the Icc protein:TRAP-type C4-dicarboxylate transport system, small permease component:TRAP-type C4-dicarboxylate transport system, small permease component:CO dehydrogenase maturation factor:CO dehydrogenase maturation factor:ABC-type spermidine/putrescine transport systems, ATPase components:ABC-type spermidine/putrescine transport systems, ATPase components:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:L-serine ammonia-lyase activity:fumarate hydratase activity:transporter activity:binding:ATP binding:gluconeogenesis:electron transport:mitochondrial electron transport, NADH to ubiquinone:regulation of transcription, DNA-dependent:transport:anion transport:NADH dehydrogenase (ubiquinone) activity:protein transporter activity:cobalamin biosynthetic process:protein secretion:putrescine-importing ATPase activity:spermidine-importing ATPase activity:polyamine transport:transferase activity:hydrolase activity:peptidyl-histidine phosphorylation:cobyrinic acid a,c-diamide synthase activity:ATP synthesis coupled electron transport:iron-sulfur cluster binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Methane metabolism:Methane metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:cbiD:cbiD:sda_mono:sda_mono:ttdA_fumA_fumB:ttdA_fumA_fumB:potA:potA:RND_mfp:RND_mfp:nuoB_fam:nuoB_fam:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Carbohydrate Metabolism:Energy metabolism:Electron transport:Glycolysis/gluconeogenesis:Regulatory functions:Small molecule interactions:Transport and binding proteins:Unknown substrate:Amino acids, peptides and amines:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis of cofactors, prosthetic groups, and carriers:Transport and binding proteins:Regulatory functions:Energy metabolism:Heme, porphyrin, and cobalamin:Amino acids, peptides and amines:Unknown substrate:Small molecule interactions:Glycolysis/gluconeogenesis:Electron transport:Global:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Cellular Processes:Signal Transduction:Cell Motility:Membrane Transport:Environmental Information Processing:Global:Metabolism" 69 "Energy production and conversion:Energy production and conversion:Uncharacterized conserved protein:Uncharacterized conserved protein:Acetyltransferases:Acetyltransferases:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Uncharacterized membrane protein (homolog of Drosophila rhomboid):Uncharacterized membrane protein (homolog of Drosophila rhomboid):ABC-type Mn2+/Zn2+ transport systems, permease components:ABC-type Mn2+/Zn2+ transport systems, permease components:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:NADH dehydrogenase, FAD-containing subunit:NADH dehydrogenase, FAD-containing subunit:Uncharacterized conserved protein:Uncharacterized conserved protein:TRAP-type C4-dicarboxylate transport system, large permease component:TRAP-type C4-dicarboxylate transport system, large permease component:Predicted membrane protein:Predicted membrane protein:Predicted flavoproteins:Predicted flavoproteins:FOG: GGDEF domain:FOG: GGDEF domain:Sugar phosphate permease:Sugar phosphate permease:Putative hemolysin:Putative hemolysin:ABC-type phosphate/phosphonate transport system, periplasmic component:ABC-type phosphate/phosphonate transport system, periplasmic component:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Na+/panthothenate symporter:Na+/panthothenate symporter:Site-specific recombinase XerD:Site-specific recombinase XerD:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:DNA binding:sequence-specific DNA binding transcription factor activity:actin binding:catalytic activity:NADH dehydrogenase activity:alkaline phosphatase activity:aminoacyl-tRNA ligase activity:signal transducer activity:transporter activity:ATP binding:electron transport:DNA recombination:regulation of transcription, DNA-dependent:tRNA aminoacylation for protein translation:transport:sodium ion transport:signal transduction:N-acetyltransferase activity:metabolic process:methyltransferase activity:biosynthetic process:cyclic nucleotide biosynthetic process:DNA integration:sodium ion transmembrane transporter activity:pantothenate transmembrane transporter activity:phosphonate transmembrane transporter activity:phosphonate transport:pantothenate transmembrane transport:oxidoreductase activity:transferase activity, transferring acyl groups:transferase activity, transferring nitrogenous groups:phosphorus-oxygen lyase activity:peptidyl-histidine phosphorylation:pyridoxal phosphate binding:sodium ion binding:intracellular signal transduction:ATPase activity, coupled to transmembrane movement of substances:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:ABC transporters:ABC transporters:Two-component system:Two-component system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:GGDEF:GGDEF:TIGR00275:TIGR00275:dctM:dctM:sss:sss:Metabolism:Poorly characterized:Signal Transduction:Membrane Transport:Environmental Information Processing:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Carbohydrates, organic alcohols, and acids:Small molecule interactions:Signal Transduction:Environmental Information Processing:Signal transduction:Unknown function:Transport and binding proteins:Regulatory functions:Other:Enzymes of unknown specificity:Cations and iron carrying compounds:Membrane Transport:Regulatory functions:Small molecule interactions:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Unknown function:Enzymes of unknown specificity:Signal transduction:Other:Information storage and processing:Cellular processes and signaling" 70 "Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Phosphate uptake regulator:Phosphate uptake regulator:Predicted membrane protein:Predicted membrane protein:Predicted flavin-nucleotide-binding protein:Predicted flavin-nucleotide-binding protein:nucleic acid binding:response to stress:FMN binding:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:phoU_full:phoU_full:Metabolism:Poorly characterized:Cellular processes and signaling:Anions:Transport and binding proteins:Poorly characterized:Metabolism:Cellular processes and signaling:Transport and binding proteins:Anions" 71 "Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Molecular chaperone (small heat shock protein):Molecular chaperone (small heat shock protein):Superfamily I DNA and RNA helicases:Superfamily I DNA and RNA helicases:Diaminopimelate epimerase:Diaminopimelate epimerase:Phosphoglycerate mutase 1:Phosphoglycerate mutase 1:Cytosine/adenosine deaminases:Cytosine/adenosine deaminases:Predicted xylanase/chitin deacetylase:Predicted xylanase/chitin deacetylase:FOG: CheY-like receiver:FOG: CheY-like receiver:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase:Predicted glycosyltransferases:Predicted glycosyltransferases:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Flagellar basal body-associated protein:Flagellar basal body-associated protein:Predicted Rossmann fold nucleotide-binding protein:Predicted Rossmann fold nucleotide-binding protein:Anti-sigma regulatory factor (Ser/Thr protein kinase):Anti-sigma regulatory factor (Ser/Thr protein kinase):FOG: GAF domain:FOG: GAF domain:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:DNA binding:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity:ATP-dependent DNA helicase activity:cytosine deaminase activity:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity:hydrolase activity, hydrolyzing O-glycosyl compounds:phosphoglycerate mutase activity:protein kinase CK2 activity:binding:ATP binding:carbohydrate metabolic process:glucose metabolic process:glycolysis:DNA repair:regulation of transcription, DNA-dependent:sulfur compound metabolic process:chemotaxis:zinc ion binding:diaminopimelate epimerase activity:lysine biosynthetic process via diaminopimelate:folic acid-containing compound biosynthetic process:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:glyceraldehyde-3-phosphate metabolic process:antisigma factor binding:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity:NAD binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Lysine biosynthesis:Lysine biosynthesis:Methane metabolism:Methane metabolism:Folate biosynthesis:Folate biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:ant_ant_sig:ant_ant_sig:DapF:DapF:TIGR00730:TIGR00730:pgm_1:pgm_1:folK:folK:GAPDH-I:GAPDH-I:Regulatory functions:Metabolism of Cofactors and Vitamins:Signal Transduction:Cell Motility:Metabolism:Metabolism:Environmental Information Processing:Cellular Processes:Global:Glycolysis/gluconeogenesis:Protein interactions:Conserved:Aspartate family:Folic acid:Energy metabolism:Regulatory functions:Hypothetical proteins:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Energy Metabolism:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Amino Acid Metabolism:Protein interactions:Hypothetical proteins:Conserved:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 72 "Energy production and conversion:Energy production and conversion:Glutamate dehydrogenase/leucine dehydrogenase:Glutamate dehydrogenase/leucine dehydrogenase:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:Nitrogenase molybdenum-iron protein, alpha and beta chains:Nitrogenase molybdenum-iron protein, alpha and beta chains:Predicted phosphoglycerate mutase, AP superfamily:Predicted phosphoglycerate mutase, AP superfamily:Mu-like prophage protein gp16:Mu-like prophage protein gp16:Phage-related terminase:Phage-related terminase:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:ATP binding:electron transport:cellular amino acid metabolic process:nitrogen fixation:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:nitrogenase activity:oxidoreductase activity:iron-iron nitrogenase activity:molybdenum-iron nitrogenase activity:vanadium-iron nitrogenase activity:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity:metal ion binding:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:nifK:nifK:Membrane Transport:Global:Metabolism:Energy Metabolism:Central intermediary metabolism:Nitrogen fixation:Metabolism:Poorly characterized:Xenobiotics Biodegradation and Metabolism:Central intermediary metabolism:Nitrogen fixation:Global:Environmental Information Processing:Metabolism:Metabolism:Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport" 73 "Predicted membrane protein:Predicted membrane protein:Phage-related holin (Lysis protein):Phage-related holin (Lysis protein):Mu-like prophage protein gpG:Mu-like prophage protein gpG:Bacteriophage capsid protein:Bacteriophage capsid protein:Bacteriophage tail assembly protein:Bacteriophage tail assembly protein:DNA binding:General function prediction only:General function prediction only:Function unknown:Function unknown:portal_lambda:portal_lambda:holin_tox_secr:holin_tox_secr:tail_comp_S:tail_comp_S:Mobile and extrachromosomal element functions:Prophage functions:Poorly characterized:Prophage functions:Poorly characterized:Mobile and extrachromosomal element functions" 74 "Energy production and conversion:Energy production and conversion:F0F1-type ATP synthase, beta subunit:F0F1-type ATP synthase, beta subunit:F0F1-type ATP synthase, alpha subunit:F0F1-type ATP synthase, alpha subunit:F0F1-type ATP synthase, gamma subunit:F0F1-type ATP synthase, gamma subunit:Anaerobic dehydrogenases, typically selenocysteine-containing:Anaerobic dehydrogenases, typically selenocysteine-containing:F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit):F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit):F0F1-type ATP synthase, subunit a:F0F1-type ATP synthase, subunit a:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Adenylate kinase and related kinases:Adenylate kinase and related kinases:F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K:F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K:F0F1-type ATP synthase, subunit b:F0F1-type ATP synthase, subunit b:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Ferredoxin:Ferredoxin:Heterodisulfide reductase, subunit A and related polyferredoxins:Heterodisulfide reductase, subunit A and related polyferredoxins:Inorganic pyrophosphatase/exopolyphosphatase:Inorganic pyrophosphatase/exopolyphosphatase:Predicted metal-dependent hydrolase:Predicted metal-dependent hydrolase:ATP sulfurylase (sulfate adenylyltransferase):ATP sulfurylase (sulfate adenylyltransferase):Nitrate reductase gamma subunit:Nitrate reductase gamma subunit:Polysulphide reductase:Polysulphide reductase:Nucleotide transport and metabolism:Nucleotide transport and metabolism:sulfate assimilation:hydrogen-transporting two-sector ATPase activity:adenylate kinase activity:dihydrolipoyl dehydrogenase activity:inorganic diphosphatase activity:sulfate adenylyltransferase (ATP) activity:structural molecule activity:ATP binding:electron transport:nucleobase-containing compound metabolic process:sulfur compound metabolic process:phosphorus metabolic process:hydrogen-exporting ATPase activity, phosphorylative mechanism:electron carrier activity:adenylyl-sulfate reductase activity:sulfate assimilation via adenylyl sulfate reduction:methanogenesis:ATP synthesis coupled proton transport:proton transport:hydrogen-translocating F-type ATPase activity:oxidoreductase activity:sulfide oxidation, using siroheme sulfite reductase:manganese ion binding:molybdenum ion binding:hydrogen ion transporting ATP synthase activity, rotational mechanism:proton-transporting ATPase activity, rotational mechanism:flavin adenine dinucleotide binding:iron-sulfur cluster binding:CoB--CoM heterodisulfide reductase activity:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Oxidative phosphorylation:Oxidative phosphorylation:Purine metabolism:Purine metabolism:Selenocompound metabolism:Selenocompound metabolism:Methane metabolism:Methane metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:sopT:sopT:atpA:atpA:atpD:atpD:ATP_synt_6_or_A:ATP_synt_6_or_A:ATPsyn_F1gamma:ATPsyn_F1gamma:ATP_synt_epsi:ATP_synt_epsi:ATP_synt_c:ATP_synt_c:aprB:aprB:aprA:aprA:Metabolism:Poorly characterized:Metabolism:Metabolism:Metabolism of Other Amino Acids:Energy metabolism:Nucleotide Metabolism:Energy Metabolism:Central intermediary metabolism:Sulfur metabolism:Central intermediary metabolism:Energy metabolism:Metabolism:Global:Metabolism of Other Amino Acids:Nucleotide Metabolism:Energy Metabolism:Metabolism:Poorly characterized:Metabolism:Global:Sulfur metabolism:ATP-proton motive force interconversion:ATP-proton motive force interconversion" 75 "Aspartate oxidase:Aspartate oxidase:Chloride channel protein EriC:Chloride channel protein EriC:Geranylgeranyl pyrophosphate synthase:Geranylgeranyl pyrophosphate synthase:FAD synthase:FAD synthase:Quinolinate synthase:Quinolinate synthase:ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member:ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member:Lipoprotein signal peptidase:Lipoprotein signal peptidase:Na+-dependent transporters of the SNF family:Na+-dependent transporters of the SNF family:Bacterial cell division membrane protein:Bacterial cell division membrane protein:Predicted alternative thymidylate synthase:Predicted alternative thymidylate synthase:Exonuclease VII, large subunit:Exonuclease VII, large subunit:Integral membrane protein CcmA involved in cell shape determination:Integral membrane protein CcmA involved in cell shape determination:Methylase involved in ubiquinone/menaquinone biosynthesis:Methylase involved in ubiquinone/menaquinone biosynthesis:Xanthine/uracil permeases:Xanthine/uracil permeases:Mg/Co/Ni transporter MgtE (contains CBS domain):Mg/Co/Ni transporter MgtE (contains CBS domain):Holliday junction resolvasome, helicase subunit:Holliday junction resolvasome, helicase subunit:Ribosomal protein L11 methylase:Ribosomal protein L11 methylase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:ABC-type phosphate/phosphonate transport system, ATPase component:ABC-type phosphate/phosphonate transport system, ATPase component:ABC-type phosphate/phosphonate transport system, permease component:ABC-type phosphate/phosphonate transport system, permease component:ABC-type tungstate transport system, periplasmic component:ABC-type tungstate transport system, periplasmic component:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):nucleotide binding:nucleic acid binding:DNA binding:catalytic activity:methylated-DNA-[protein]-cysteine S-methyltransferase activity:FMN adenylyltransferase activity:geranyltranstransferase activity:uracil phosphoribosyltransferase activity:transporter activity:voltage-gated chloride channel activity:neurotransmitter:sodium symporter activity:ATP binding:electron transport:dTMP biosynthetic process:DNA repair:DNA catabolic process:DNA recombination:regulation of transcription, DNA-dependent:protein methylation:proteolysis:transport:cation transport:chloride transport:neurotransmitter transport:cell cycle:signal transduction:metabolic process:methyltransferase activity:protein methyltransferase activity:isoprenoid biosynthetic process:cation transmembrane transporter activity:regulation of cell shape:riboflavin kinase activity:L-aspartate oxidase activity:crossover junction endodeoxyribonuclease activity:exodeoxyribonuclease V activity:exodeoxyribonuclease VII activity:quinolinate synthetase A activity:signal peptidase II activity:riboflavin biosynthetic process:protein secretion:four-way junction helicase activity:NAD biosynthetic process:phosphonate transmembrane-transporting ATPase activity:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:phosphonate transport:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:flavin adenine dinucleotide binding:thymidylate synthase (FAD) activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:One carbon pool by folate:One carbon pool by folate:Riboflavin metabolism:Riboflavin metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Protein export:Protein export:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:lspA:lspA:ribF:ribF:sensory_box:sensory_box:xseA:xseA:mgtE:mgtE:nadB:nadB:ruvB:ruvB:ncs2:ncs2:PhnE:PhnE:recD_rel:recD_rel:thyX:thyX:rodA_shape:rodA_shape:ABC_phnC:ABC_phnC:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Nucleosides, purines and pyrimidines:Cations and iron carrying compounds:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:Regulatory functions:Small molecule interactions:DNA metabolism:Degradation of DNA:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Anions:Cations and iron carrying compounds:Nucleosides, purines and pyrimidines:Cellular processes:Cell division:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Anions:Protein and peptide secretion and trafficking:DNA replication, recombination, and repair:Degradation of DNA:Small molecule interactions:2'-Deoxyribonucleotide metabolism:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Replication and Repair:Folding Sorting and Degradation:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Riboflavin, FMN, and FAD:Biosynthesis of cofactors, prosthetic groups, and carriers:Unknown function:Nucleotide Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Cellular processes:Amino Acid Metabolism:Transport and binding proteins:Metabolism of Cofactors and Vitamins:Protein fate:DNA metabolism:Regulatory functions:Metabolism of Terpenoids and Polyketides:Purines, pyrimidines, nucleosides, and nucleotides:Genetic Information Processing:Folding Sorting and Degradation:Pyridine nucleotides:Replication and Repair:Riboflavin, FMN, and FAD:Enzymes of unknown specificity:Environmental Information Processing:Membrane Transport:Cell division:Global:Metabolism" 76 "ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Ribosomal protein S1:Ribosomal protein S1:Predicted permeases:Predicted permeases:Predicted glycosyltransferases:Predicted glycosyltransferases:Flagellar GTP-binding protein:Flagellar GTP-binding protein:Predicted transcriptional regulators:Predicted transcriptional regulators:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:ABC-type tungstate transport system, permease component:ABC-type tungstate transport system, permease component:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:structural constituent of ribosome:ATP-dependent peptidase activity:ATP binding:electron transport:regulation of transcription, DNA-dependent:translation:proteolysis:transcription factor binding:7S RNA binding:endopeptidase La activity:cobalamin biosynthetic process:oxidoreductase activity:nucleoside-triphosphatase activity:plasmid partitioning:cobyrinic acid a,c-diamide synthase activity:sequence-specific DNA binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell motility:Cell motility:ABC transporters:ABC transporters:Flagellar assembly:Flagellar assembly:Ribosome:Ribosome:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:parB_part:parB_part:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Genetic Information Processing:Cellular Processes:Poorly characterized:Metabolism:Information storage and processing:Environmental Information Processing:Genetic Information Processing:Cell Motility:Membrane Transport:Translation:Cellular processes and signaling:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Translation" 77 "Energy production and conversion:Energy production and conversion:Ni,Fe-hydrogenase I large subunit:Ni,Fe-hydrogenase I large subunit:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Glycerol kinase:Glycerol kinase:Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family):Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family):Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Membrane-fusion protein:Membrane-fusion protein:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:FOG: HEAT repeat:FOG: HEAT repeat:Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs:Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs:Outer membrane protein:Outer membrane protein:Predicted signal transduction protein:Predicted signal transduction protein:Ni,Fe-hydrogenase I small subunit:Ni,Fe-hydrogenase I small subunit:Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain:Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain:Flp pilus assembly protein CpaB:Flp pilus assembly protein CpaB:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Flp pilus assembly protein, ATPase CpaE:Flp pilus assembly protein, ATPase CpaE:Flp pilus assembly protein, secretin CpaC:Flp pilus assembly protein, secretin CpaC:Signal transduction histidine kinase:Signal transduction histidine kinase:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):catalytic activity:fumarate hydratase activity:glycerol kinase activity:signal transducer activity:transporter activity:binding:iron ion binding:ATP binding:carbohydrate metabolic process:glycerol-3-phosphate metabolic process:electron transport:mitochondrial electron transport, NADH to ubiquinone:regulation of transcription, DNA-dependent:transport:chemotaxis:signal transduction:NADH dehydrogenase (ubiquinone) activity:lipid binding:protein transporter activity:formate dehydrogenase (NAD+) activity:glycerophosphodiester phosphodiesterase activity:ferredoxin hydrogenase activity:electron carrier activity:nucleotide metabolic process:cobalamin biosynthetic process:protein secretion:nickel ion binding:hydrolase activity:peptidyl-histidine phosphorylation:pyruvate synthase activity:heme binding:thiamine pyrophosphate binding:hydrogenase (acceptor) activity:cobyrinic acid a,c-diamide synthase activity:metal ion binding:2-oxoglutarate synthase activity:iron-sulfur cluster binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Glycerolipid metabolism:Glycerolipid metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:HDIG:HDIG:hydA:hydA:ttdB_fumA_fumB:ttdB_fumA_fumB:MIP:MIP:glycerol_kin:glycerol_kin:RND_mfp:RND_mfp:outer_NodT:outer_NodT:PorB_KorB:PorB_KorB:TIGR02687:TIGR02687:pilus_cpaB:pilus_cpaB:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Electron transport:Other:Regulatory functions:Small molecule interactions:Transport and binding proteins:Unknown substrate:Porins:Cellular processes and signaling:Metabolism:Metabolism:Metabolism:Cellular processes and signaling:Transport and binding proteins:Regulatory functions:Energy metabolism:Porins:Unknown substrate:Small molecule interactions:Other:Electron transport:Global:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Lipid Metabolism:Energy Metabolism:Global:Metabolism:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Carbohydrate Metabolism:Energy metabolism" 78 "Purine nucleoside phosphorylase:Purine nucleoside phosphorylase:tRNA-dihydrouridine synthase:tRNA-dihydrouridine synthase:Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases:Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases:Leucyl aminopeptidase:Leucyl aminopeptidase:tRNA delta(2)-isopentenylpyrophosphate transferase:tRNA delta(2)-isopentenylpyrophosphate transferase:Translation initiation factor 1 (IF-1):Translation initiation factor 1 (IF-1):ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member:ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member:Single-stranded DNA-binding protein:Single-stranded DNA-binding protein:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:Sec-independent protein secretion pathway component TatC:Sec-independent protein secretion pathway component TatC:Acetyl-CoA carboxylase alpha subunit:Acetyl-CoA carboxylase alpha subunit:Predicted ATP-dependent protease:Predicted ATP-dependent protease:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:ABC-type transport system involved in resistance to organic solvents, ATPase component:ABC-type transport system involved in resistance to organic solvents, ATPase component:Flagellar motor component:Flagellar motor component:Uncharacterized protein (competence- and mitomycin-induced):Uncharacterized protein (competence- and mitomycin-induced):Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:nucleotide binding:single-stranded DNA binding:RNA binding:structural constituent of ribosome:translation initiation factor activity:DNA-directed DNA polymerase activity:GTPase activity:acetyl-CoA carboxylase activity:dimethylallyltranstransferase activity:ATP-dependent peptidase activity:leucyl aminopeptidase activity:serine-type endopeptidase activity:ribonuclease P activity:purine-nucleoside phosphorylase activity:transporter activity:ATP binding:nucleobase-containing compound metabolic process:DNA replication:tRNA modification:translation:translational initiation:proteolysis:fatty acid biosynthetic process:transport:tRNA processing:protein-synthesizing GTPase activity:protein transporter activity:L-fuculose-phosphate aldolase activity:exodeoxyribonuclease V activity:biosynthetic process:nucleoside metabolic process:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:oxidoreductase activity:ATPase activity:nucleoside-triphosphatase activity:manganese ion binding:metal ion binding:flavin adenine dinucleotide binding:tRNA dimethylallyltransferase activity:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Fructose and mannose metabolism:Fructose and mannose metabolism:Fatty acid biosynthesis:Fatty acid biosynthesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Glutathione metabolism:Glutathione metabolism:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Ribosome:Ribosome:DNA replication:DNA replication:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:infA:infA:YaeB_AF0241:YaeB_AF0241:miaA:miaA:cinA_cterm:cinA_cterm:ssb:ssb:tatC:tatC:rpmH_bact:rpmH_bact:recD_rel:recD_rel:PNPH-PUNA-XAPA:PNPH-PUNA-XAPA:HEQRo_perm_3TM:HEQRo_perm_3TM:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Translation:Replication and Repair:Membrane Transport:Signal Transduction:Cell Motility:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:DNA replication, recombination, and repair:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Translation factors:Protein and peptide secretion and trafficking:Amino acids, peptides and amines:Enzymes of unknown specificity:DNA metabolism:Protein synthesis:Protein fate:Transport and binding proteins:Unknown function:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Amino acids, peptides and amines:Unknown function:Enzymes of unknown specificity:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Folding Sorting and Degradation" 79 "Aspartate ammonia-lyase:Aspartate ammonia-lyase:Predicted metal-dependent hydrolase:Predicted metal-dependent hydrolase:Predicted metal-dependent hydrolase:Predicted metal-dependent hydrolase:Mu-like prophage protein gp45:Mu-like prophage protein gp45:Amino acid transport and metabolism:Amino acid transport and metabolism:fumarate metabolic process:proteolysis:aspartate metabolic process:metallopeptidase activity:zinc ion binding:aspartate ammonia-lyase activity:phosphorylation:transferase activity, transferring phosphorus-containing groups:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:General function prediction only:General function prediction only:Function unknown:Function unknown:phage_P2_V:phage_P2_V:Global:Metabolism:Mobile and extrachromosomal element functions:Prophage functions:Metabolism:Poorly characterized:Amino Acid Metabolism:Global:Metabolism:Prophage functions:Mobile and extrachromosomal element functions:Metabolism:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Amino Acid Metabolism:Energy Metabolism" 80 "Energy production and conversion:Energy production and conversion:Putative translation initiation inhibitor, yjgF family:Putative translation initiation inhibitor, yjgF family:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Na+/H+ antiporter:Na+/H+ antiporter:Uncharacterized conserved protein:Uncharacterized conserved protein:Phage terminase, small subunit:Phage terminase, small subunit:Amino acid transport and metabolism:Amino acid transport and metabolism:DNA binding:deoxyribonuclease activity:transporter activity:DNA methylation:transport:sodium ion transport:regulation of pH:sodium:hydrogen antiporter activity:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Metabolic pathways:Metabolic pathways:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00004:TIGR00004:dcm:dcm:sm_term_P27:sm_term_P27:tape_meas_TP901:tape_meas_TP901:Transcription:Degradation of RNA:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Amino Acid Metabolism:DNA metabolism:Prophage functions:Transcription:Mobile and extrachromosomal element functions:Degradation of RNA:DNA replication, recombination, and repair:Global:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair" 81 "Energy production and conversion:Energy production and conversion:Xaa-Pro aminopeptidase:Xaa-Pro aminopeptidase:Transketolase:Transketolase:Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain:Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain:Acetyltransferase (isoleucine patch superfamily):Acetyltransferase (isoleucine patch superfamily):Dihydroxyacid dehydratase/phosphogluconate dehydratase:Dihydroxyacid dehydratase/phosphogluconate dehydratase:S-adenosylmethionine synthetase:S-adenosylmethionine synthetase:Dihydrodipicolinate reductase:Dihydrodipicolinate reductase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Panthothenate synthetase:Panthothenate synthetase:Nucleoside-diphosphate-sugar epimerases:Nucleoside-diphosphate-sugar epimerases:Methionine synthase II (cobalamin-independent):Methionine synthase II (cobalamin-independent):Predicted ATPase or kinase:Predicted ATPase or kinase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Long-chain acyl-CoA synthetases (AMP-forming):Long-chain acyl-CoA synthetases (AMP-forming):Lactate dehydrogenase and related dehydrogenases:Lactate dehydrogenase and related dehydrogenases:Na+/H+ antiporter NhaD and related arsenite permeases:Na+/H+ antiporter NhaD and related arsenite permeases:ABC-type spermidine/putrescine transport system, permease component I:ABC-type spermidine/putrescine transport system, permease component I:Oxygen-sensitive ribonucleoside-triphosphate reductase:Oxygen-sensitive ribonucleoside-triphosphate reductase:Flagellar biosynthesis pathway, component FlhB:Flagellar biosynthesis pathway, component FlhB:Flagellar biosynthesis pathway, component FliR:Flagellar biosynthesis pathway, component FliR:Cell division protein:Cell division protein:Outer membrane protein:Outer membrane protein:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:catalytic activity:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity:IMP cyclohydrolase activity:UDP-glucose 4-epimerase activity:dihydroxy-acid dehydratase activity:X-Pro dipeptidase activity:fatty-acyl-CoA synthase activity:long-chain fatty acid-CoA ligase activity:methionine adenosyltransferase activity:pantoate-beta-alanine ligase activity:phosphoglycerate dehydrogenase activity:phosphoribosylformylglycinamidine synthase activity:phosphoribosylaminoimidazolecarboxamide formyltransferase activity:transketolase activity:transporter activity:protein binding:ATP binding:pentose-phosphate shunt:electron transport:purine nucleotide biosynthetic process:proteolysis:methionine metabolic process:creatine metabolic process:protein targeting:cellular aromatic compound metabolic process:one-carbon metabolic process:transport:metabolic process:metalloexopeptidase activity:zinc ion binding:2-dehydro-3-deoxyglucarate aldolase activity:dihydrodipicolinate reductase activity:ribonucleoside-triphosphate reductase activity:branched chain family amino acid biosynthetic process:methionine biosynthetic process:lysine biosynthetic process via diaminopimelate:protein secretion:pantothenate biosynthetic process:transferase activity, transferring acyl groups:creatinase activity:pyridoxal phosphate binding:short-chain fatty acid-CoA ligase activity:medium-chain fatty acid-CoA ligase activity:very long-chain fatty acid-CoA ligase activity:cellular metabolic process:2-oxoglutarate synthase activity:methionine adenosyltransferase regulator activity:coenzyme binding:NAD binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Pentose phosphate pathway:Pentose phosphate pathway:Galactose metabolism:Galactose metabolism:Ascorbate and aldarate metabolism:Ascorbate and aldarate metabolism:Fatty acid metabolism:Fatty acid metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Lysine biosynthesis:Selenocompound metabolism:Selenocompound metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Methane metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:panC:panC:dapB:dapB:ilvD:ilvD:HI0065_YjeE:HI0065_YjeE:tktlase_bact:tktlase_bact:flhB:flhB:metK:metK:met_syn_B12ind:met_syn_B12ind:fliR:fliR:NrdD:NrdD:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Purines, pyrimidines, nucleosides, and nucleotides:Other:Pentose phosphate pathway:2'-Deoxyribonucleotide metabolism:Chemotaxis and motility:Enzymes of unknown specificity:Aspartate family:Pyruvate family:Pantothenate and coenzyme A:Central intermediary metabolism:Energy metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Cellular processes:Unknown function:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Other:Energy metabolism:Pentose phosphate pathway:Global:2'-Deoxyribonucleotide metabolism:Cellular processes:Chemotaxis and motility:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aspartate family:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Cellular processes and signaling:Metabolism:Poorly characterized:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Cellular Processes" 82 "Energy production and conversion:Energy production and conversion:Peptidyl-tRNA hydrolase:Peptidyl-tRNA hydrolase:Fe-S oxidoreductase:Fe-S oxidoreductase:Ribonuclease HI:Ribonuclease HI:Predicted GTPase:Predicted GTPase:Cytosine/adenosine deaminases:Cytosine/adenosine deaminases:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:DNA polymerase I - 3'-5' exonuclease and polymerase domains:DNA polymerase I - 3'-5' exonuclease and polymerase domains:UDP-N-acetylglucosamine enolpyruvyl transferase:UDP-N-acetylglucosamine enolpyruvyl transferase:Periplasmic protein TonB, links inner and outer membranes:Periplasmic protein TonB, links inner and outer membranes:DNA modification methylase:DNA modification methylase:Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities:Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities:Predicted glycosyltransferases:Predicted glycosyltransferases:TRAP-type C4-dicarboxylate transport system, periplasmic component:TRAP-type C4-dicarboxylate transport system, periplasmic component:Pyruvate-formate lyase:Pyruvate-formate lyase:Membrane transporters of cations and cationic drugs:Membrane transporters of cations and cationic drugs:Putative multicopper oxidases:Putative multicopper oxidases:GTPases:GTPases:Aldehyde:ferredoxin oxidoreductase:Aldehyde:ferredoxin oxidoreductase:ABC-type phosphate/phosphonate transport system, periplasmic component:ABC-type phosphate/phosphonate transport system, periplasmic component:Type II secretory pathway, component ExeA (predicted ATPase):Type II secretory pathway, component ExeA (predicted ATPase):Uncharacterized conserved protein:Uncharacterized conserved protein:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:DNA-directed DNA polymerase activity:GTPase activity:aminoacyl-tRNA hydrolase activity:coproporphyrinogen oxidase activity:cystathionine beta-lyase activity:dCMP deaminase activity:ribonuclease H activity:sugar:hydrogen symporter activity:iron ion transmembrane transporter activity:copper ion binding:ATP binding:GTP binding:glucose metabolic process:electron transport:DNA replication:DNA methylation:regulation of transcription, DNA-dependent:tRNA modification:RNA catabolic process:translation:aminoacyl-tRNA hydrolase reaction:porphyrin-containing compound biosynthetic process:transport:iron ion transport:signal transduction:N-methyltransferase activity:zinc ion binding:5'-3' exonuclease activity:protein transporter activity:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity:formate C-acetyltransferase activity:phosphoenolpyruvate-protein phosphotransferase activity:site-specific DNA-methyltransferase (adenine-specific) activity:electron carrier activity:biosynthetic process:phosphoenolpyruvate-dependent sugar phosphotransferase system:protein transport:ferrous iron transmembrane transporter activity:phosphonate transmembrane transporter activity:ferrous iron transport:phosphonate transport:phosphorylation:oxidoreductase activity:transferase activity, transferring nitrogenous groups:peptidyl-histidine phosphorylation:UDP-N-acetylgalactosamine biosynthetic process:pyridoxal phosphate binding:aldehyde ferredoxin oxidoreductase activity:iron-sulfur cluster binding:coproporphyrinogen dehydrogenase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Selenocompound metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Butanoate metabolism:Butanoate metabolism:Thiamine metabolism:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Nitrogen metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Phosphotransferase system (PTS):Phosphotransferase system (PTS):DNA replication:DNA replication:Base excision repair:Base excision repair:Nucleotide excision repair:Nucleotide excision repair:Homologous recombination:Homologous recombination:Sulfur relay system:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:small_GTP:small_GTP:pth:pth:hemN_rel:hemN_rel:dctP:dctP:murA:murA:tonB_Cterm:tonB_Cterm:PTS_I_fam:PTS_I_fam:GTP_HflX:GTP_HflX:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Membrane Transport:Regulatory functions:Small molecule interactions:Protein synthesis:Other:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Folding Sorting and Degradation:Replication and Repair:Cell envelope:Biosynthesis of cofactors, prosthetic groups, and carriers:Unknown function:Transport and binding proteins:Protein synthesis:Regulatory functions:Biosynthesis and degradation of murein sacculus and peptidoglycan:Heme, porphyrin, and cobalamin:General:Cations and iron carrying compounds:Carbohydrates, organic alcohols, and acids:Other:Small molecule interactions:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing" 83 "Energy production and conversion:Energy production and conversion:Glucose-6-phosphate isomerase:Glucose-6-phosphate isomerase:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Glycogen synthase:Glycogen synthase:4-hydroxybenzoate polyprenyltransferase and related prenyltransferases:4-hydroxybenzoate polyprenyltransferase and related prenyltransferases:Cytosine deaminase and related metal-dependent hydrolases:Cytosine deaminase and related metal-dependent hydrolases:Glycosyltransferase:Glycosyltransferase:Signal transduction histidine kinase:Signal transduction histidine kinase:Predicted nucleoside-diphosphate-sugar epimerases:Predicted nucleoside-diphosphate-sugar epimerases:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:Fe-S-cluster-containing hydrogenase components 2:Fe-S-cluster-containing hydrogenase components 2:Predicted membrane protein, hemolysin III homolog:Predicted membrane protein, hemolysin III homolog:Putative threonine efflux protein:Putative threonine efflux protein:DNA-binding protein, stimulates sugar fermentation:DNA-binding protein, stimulates sugar fermentation:Predicted signal transduction protein:Predicted signal transduction protein:Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family:Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family:Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase:Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized conserved protein:Uncharacterized conserved protein:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Predicted integral membrane protein:Predicted integral membrane protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:catalytic activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:serine-type endopeptidase activity:glucose-6-phosphate isomerase activity:prenyltransferase activity:protein histidine kinase activity:binding:protein binding:ATP binding:glycogen biosynthetic process:gluconeogenesis:glycolysis:electron transport:regulation of transcription, DNA-dependent:proteolysis:amino acid transport:chemotaxis:response to stress:transcription factor binding:metabolic process:methyltransferase activity:isoprenoid biosynthetic process:cobinamide phosphate guanylyltransferase activity:formate dehydrogenase (NAD+) activity:protein-glutamate methylesterase activity:starch synthase activity:electron carrier activity:biosynthetic process:cobalamin biosynthetic process:glucan biosynthetic process:oxidoreductase activity:transferase activity:hydrolase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:cytolysis:cobyrinic acid a,c-diamide synthase activity:adenosylcobinamide kinase activity:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity:cellular metabolic process:metal ion binding:coenzyme binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Fatty acid metabolism:Fatty acid metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Tyrosine metabolism:Tyrosine metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Naphthalene degradation:Naphthalene degradation:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:sfsA:sfsA:hlyIII:hlyIII:ubiA_other:ubiA_other:glgA:glgA:Cell Motility:Signal Transduction:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Energy metabolism:Regulatory functions:Energy metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Menaquinone and ubiquinone:Small molecule interactions:Lipid Metabolism:Other:Amino Acid Metabolism:Biosynthesis and degradation of polysaccharides:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Global:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Biosynthesis and degradation of polysaccharides:Regulatory functions:Other:Small molecule interactions:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Cellular processes and signaling:Metabolism:Poorly characterized:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism" 84 "Putative translation factor (SUA5):Putative translation factor (SUA5):tRNA and rRNA cytosine-C5-methylases:tRNA and rRNA cytosine-C5-methylases:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Pseudouridylate synthases, 23S RNA-specific:Pseudouridylate synthases, 23S RNA-specific:Single-stranded DNA-specific exonuclease:Single-stranded DNA-specific exonuclease:Cobalamin biosynthesis protein CobD/CbiB:Cobalamin biosynthesis protein CobD/CbiB:N-acetylglutamate synthase (N-acetylornithine aminotransferase):N-acetylglutamate synthase (N-acetylornithine aminotransferase):Asparaginase:Asparaginase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Amino acid transport and metabolism:pseudouridine synthesis:nucleic acid binding:RNA binding:catalytic activity:adenosylmethionine-8-amino-7-oxononanoate transaminase activity:acetyl-CoA:L-glutamate N-acetyltransferase activity:asparaginase activity:glutamate N-acetyltransferase activity:DNA repair:DNA recombination:glycoprotein catabolic process:arginine biosynthetic process:zinc ion binding:5'-3' exonuclease activity:beta-aspartyl-peptidase activity:biotin biosynthetic process:cobalamin biosynthetic process:pseudouridine synthase activity:manganese ion binding:pyridoxal phosphate binding:adenosylcobinamide-phosphate synthase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Arginine and proline metabolism:Arginine and proline metabolism:Thiamine metabolism:Thiamine metabolism:Biotin metabolism:Biotin metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Base excision repair:Base excision repair:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:Sulfur relay system:Sulfur relay system:Function unknown:Function unknown:TIGR00057:TIGR00057:ArgJ:ArgJ:bioA:bioA:recJ:recJ:C4_traR_proteo:C4_traR_proteo:Metabolism:Replication and Repair:Poorly characterized:Metabolism:Information storage and processing:Global:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino acid biosynthesis:Unknown function:Mobile and extrachromosomal element functions:DNA metabolism:DNA metabolism:DNA replication, recombination, and repair:Mobile and extrachromosomal element functions:Prophage functions:Unknown function:General:Amino acid biosynthesis:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Information storage and processing:Metabolism:Poorly characterized:Biotin:Glutamate family:General:Prophage functions:DNA replication, recombination, and repair:Global:Genetic Information Processing:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Replication and Repair:Amino Acid Metabolism:Genetic Information Processing:Folding Sorting and Degradation" 85 "Energy production and conversion:Energy production and conversion:ATPase components of ABC transporters with duplicated ATPase domains:ATPase components of ABC transporters with duplicated ATPase domains:Superfamily II DNA and RNA helicases:Superfamily II DNA and RNA helicases:Predicted amidophosphoribosyltransferases:Predicted amidophosphoribosyltransferases:ABC-type transport system involved in resistance to organic solvents, periplasmic component:ABC-type transport system involved in resistance to organic solvents, periplasmic component:Predicted metal-dependent hydrolase:Predicted metal-dependent hydrolase:Ni,Fe-hydrogenase III large subunit:Ni,Fe-hydrogenase III large subunit:Flp pilus assembly protein, pilin Flp:Flp pilus assembly protein, pilin Flp:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:two-component sensor activity:two-component signal transduction system (phosphorelay):nucleotide binding:nucleic acid binding:actin binding:ATP binding:electron transport:regulation of transcription, DNA-dependent:ATP-dependent helicase activity:NADH dehydrogenase (ubiquinone) activity:ferredoxin hydrogenase activity:electron carrier activity:nucleoside metabolic process:nickel ion binding:oxidoreductase activity:ATPase activity:peptidyl-histidine phosphorylation:heme binding:NAD binding:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Methane metabolism:Methane metabolism:RNA degradation:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Metabolism:Poorly characterized:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Regulatory functions:Small molecule interactions:Genetic Information Processing:Metabolism:Folding Sorting and Degradation:Energy Metabolism:Genetic Information Processing:Energy Metabolism:Folding Sorting and Degradation:Metabolism:Regulatory functions:Small molecule interactions:Information storage and processing" 86 "Energy production and conversion:Energy production and conversion:EMAP domain:EMAP domain:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:ATPase components of ABC transporters with duplicated ATPase domains:ATPase components of ABC transporters with duplicated ATPase domains:Predicted sugar phosphatases of the HAD superfamily:Predicted sugar phosphatases of the HAD superfamily:Cell division protein FtsI/penicillin-binding protein 2:Cell division protein FtsI/penicillin-binding protein 2:UDP-N-acetylmuramate dehydrogenase:UDP-N-acetylmuramate dehydrogenase:Pyruvate-formate lyase-activating enzyme:Pyruvate-formate lyase-activating enzyme:Flagellar motor protein:Flagellar motor protein:Uncharacterized conserved protein:Uncharacterized conserved protein:ATP:corrinoid adenosyltransferase:ATP:corrinoid adenosyltransferase:Butyrate kinase:Butyrate kinase:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Site-specific recombinase XerD:Site-specific recombinase XerD:Flp pilus assembly protein TadD, contains TPR repeats:Flp pilus assembly protein TadD, contains TPR repeats:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:tRNA binding:two-component sensor activity:two-component signal transduction system (phosphorelay):DNA binding:actin binding:4-nitrophenylphosphatase activity:acetate-CoA ligase activity:methionine-tRNA ligase activity:binding:iron ion binding:ATP binding:fermentation:electron transport:DNA recombination:regulation of transcription, DNA-dependent:cell cycle:chromosome segregation:metabolic process:protein transporter activity:penicillin binding:UDP-N-acetylmuramate dehydrogenase activity:cob(I)yrinic acid a,c-diamide adenosyltransferase activity:peptidoglycan glycosyltransferase activity:electron carrier activity:cobalamin biosynthetic process:peptidoglycan biosynthetic process:peptidoglycan-based cell wall biogenesis:protein transport:DNA integration:phosphorylation:phosphotransferase activity, carboxyl group as acceptor:hydrolase activity:ATPase activity:peptidyl-histidine phosphorylation:heme binding:[formate-C-acetyltransferase]-activating enzyme activity:butyrate kinase activity:flavin adenine dinucleotide binding:cell division:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Butanoate metabolism:Butanoate metabolism:Methane metabolism:Methane metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:murB:murB:sensory_box:sensory_box:HAD-SF-IIA:HAD-SF-IIA:chap_CsaA:chap_CsaA:recomb_XerD:recomb_XerD:butyr_kinase:butyr_kinase:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Carbohydrate Metabolism:Global:DNA replication, recombination, and repair:Small molecule interactions:DNA replication, recombination, and repair:Protein and peptide secretion and trafficking:Enzymes of unknown specificity:Biosynthesis and degradation of murein sacculus and peptidoglycan:Energy metabolism:Regulatory functions:DNA metabolism:Protein fate:Unknown function:Cell envelope:Cellular Processes:Metabolism:Metabolism:Cell Motility:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Fermentation:Regulatory functions:Small molecule interactions:DNA metabolism:Fermentation:Protein fate:Protein and peptide secretion and trafficking:Unknown function:Enzymes of unknown specificity:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Energy Metabolism" 87 "Energy production and conversion:Energy production and conversion:tRNA-dihydrouridine synthase:tRNA-dihydrouridine synthase:Glycosyltransferase:Glycosyltransferase:Predicted phosphatases:Predicted phosphatases:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:UDP-glucose 4-epimerase:UDP-glucose 4-epimerase:Protoporphyrinogen oxidase:Protoporphyrinogen oxidase:Alcohol dehydrogenase, class IV:Alcohol dehydrogenase, class IV:DNA-binding protein, stimulates sugar fermentation:DNA-binding protein, stimulates sugar fermentation:Predicted signal transduction protein:Predicted signal transduction protein:Sialic acid synthase:Sialic acid synthase:Methylase involved in ubiquinone/menaquinone biosynthesis:Methylase involved in ubiquinone/menaquinone biosynthesis:Sugar phosphate permease:Sugar phosphate permease:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Predicted membrane protein:Predicted membrane protein:Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain:Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):UDP-glucose 4-epimerase activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:protein histidine kinase activity:signal transducer activity:transporter activity:ATP binding:electron transport:regulation of transcription, DNA-dependent:transport:chemotaxis:response to stress:signal transduction:tRNA processing:metabolic process:methyltransferase activity:UDP-galactopyranose mutase activity:phosphoglycolate phosphatase activity:biosynthetic process:cyclic nucleotide biosynthetic process:carbohydrate biosynthetic process:oxidoreductase activity:hydrolase activity:phosphorus-oxygen lyase activity:peptidyl-histidine phosphorylation:intracellular signal transduction:cellular metabolic process:metal ion binding:N-acylneuraminate-9-phosphate synthase activity:N-acetylneuraminate synthase activity:flavin adenine dinucleotide binding:coenzyme binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Galactose metabolism:Galactose metabolism:Fatty acid metabolism:Fatty acid metabolism:Tyrosine metabolism:Tyrosine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Naphthalene degradation:Naphthalene degradation:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:sfsA:sfsA:GGDEF:GGDEF:HAD-SF-IA-v1:HAD-SF-IA-v1:Xenobiotics Biodegradation and Metabolism:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Small molecule interactions:Other:Enzymes of unknown specificity:Other:Regulatory functions:Unknown function:Signal transduction:Global:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:Other:Small molecule interactions:Unknown function:Enzymes of unknown specificity:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Signal Transduction" 88 "Predicted Co/Zn/Cd cation transporters:Predicted Co/Zn/Cd cation transporters:Phosphoribosylaminoimidazole (AIR) synthetase:Phosphoribosylaminoimidazole (AIR) synthetase:Superfamily II DNA and RNA helicases:Superfamily II DNA and RNA helicases:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Periplasmic serine proteases (ClpP class):Periplasmic serine proteases (ClpP class):ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:Flagellar motor component:Flagellar motor component:Putative transcriptional regulator, homolog of Bvg accessory factor:Putative transcriptional regulator, homolog of Bvg accessory factor:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:ciliary or flagellar motility:nucleic acid binding:motor activity:catalytic activity:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity:pantothenate kinase activity:phosphoribosylformylglycinamidine cyclo-ligase activity:transporter activity:ATP binding:'de novo' IMP biosynthetic process:proteolysis:transport:cation transport:chemotaxis:signal transduction:ATP-dependent helicase activity:cation transmembrane transporter activity:endopeptidase Clp activity:transcription activator activity:peptidyl-histidine phosphorylation:positive regulation of transcription, DNA-dependent:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:RNA degradation:RNA degradation:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:baf:baf:SppA_dom:SppA_dom:purM:purM:CDF:CDF:HEQRo_perm_3TM:HEQRo_perm_3TM:MotA1:MotA1:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Cations and iron carrying compounds:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Cell Motility:Metabolism:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:Purine ribonucleotide biosynthesis:Degradation of proteins, peptides, and glycopeptides:Amino acids, peptides and amines:Cations and iron carrying compounds:Pantothenate and coenzyme A:Purines, pyrimidines, nucleosides, and nucleotides:Protein fate:Transport and binding proteins:Biosynthesis of cofactors, prosthetic groups, and carriers:Signal Transduction:Membrane Transport:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Amino acids, peptides and amines" 89 "Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:protein histidine kinase activity:ATP binding:peptidyl-histidine phosphorylation:Signal transduction mechanisms:Signal transduction mechanisms:Cellular processes and signaling:Cellular processes and signaling" 90 "Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog:DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog:Ribosome-associated protein Y (PSrp-1):Ribosome-associated protein Y (PSrp-1):Predicted transcriptional regulators:Predicted transcriptional regulators:Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type):Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type):Nitrate/nitrite transporter:Nitrate/nitrite transporter:Plasmid maintenance system antidote protein:Plasmid maintenance system antidote protein:Plasmid maintenance system killer protein:Plasmid maintenance system killer protein:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:signal transducer activity:transporter activity:sugar:hydrogen symporter activity:binding:transcription initiation, DNA-dependent:regulation of transcription, DNA-dependent:transport:chemotaxis:signal transduction:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity:phosphoenolpyruvate-dependent sugar phosphotransferase system:response to salt stress:sigma factor activity:sequence-specific DNA binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Phosphotransferase system (PTS):Phosphotransferase system (PTS):RNA polymerase:RNA polymerase:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:yfiA:yfiA:chp_urease_rgn:chp_urease_rgn:rpoN_sigma:rpoN_sigma:PEP_exosort:PEP_exosort:antidote_HigA:antidote_HigA:Mobile and extrachromosomal element functions:Signal Transduction:Protein synthesis:Cellular Processes:Cell Motility:Transcription:Transcription:Transcription factors:Protein synthesis:Translation factors:Mobile and extrachromosomal element functions:Other:Hypothetical proteins:Conserved:Cell envelope:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Surface structures:Conserved:Other:Translation factors:Transcription factors:Cellular Processes:Environmental Information Processing:Genetic Information Processing:Cell Motility:Signal Transduction:Cell envelope:Transcription:Membrane Transport:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Genetic Information Processing:Transcription:Hypothetical proteins:Environmental Information Processing:Membrane Transport" 91 "" 92 "Energy production and conversion:Energy production and conversion:Cobalamin-5-phosphate synthase:Cobalamin-5-phosphate synthase:Signal transduction histidine kinase:Signal transduction histidine kinase:Outer membrane protein:Outer membrane protein:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:MinD superfamily P-loop ATPase containing an inserted ferredoxin domain:MinD superfamily P-loop ATPase containing an inserted ferredoxin domain:Predicted rRNA methylase:Predicted rRNA methylase:TRAP-type C4-dicarboxylate transport system, large permease component:TRAP-type C4-dicarboxylate transport system, large permease component:TRAP-type C4-dicarboxylate transport system, periplasmic component:TRAP-type C4-dicarboxylate transport system, periplasmic component:N-terminal domain of molybdenum-binding protein:N-terminal domain of molybdenum-binding protein:Transcriptional regulator, contains sigma factor-related N-terminal domain:Transcriptional regulator, contains sigma factor-related N-terminal domain:TRAP-type C4-dicarboxylate transport system, small permease component:TRAP-type C4-dicarboxylate transport system, small permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:sequence-specific DNA binding transcription factor activity:RNA binding:protein histidine kinase activity:ATP binding:electron transport:regulation of transcription, DNA-dependent:transport:cobalamin 5'-phosphate synthase activity:electron carrier activity:cobalamin biosynthetic process:peptidyl-histidine phosphorylation:hemolysis by symbiont of host erythrocytes:carbohydrate binding:transcription regulator activity:cobyrinic acid a,c-diamide synthase activity:adenosylcobinamide-GDP ribazoletransferase activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:tly:tly:dctM:dctM:dctP:dctP:Metabolism:Cellular processes and signaling:Information storage and processing:Unknown function:Transport and binding proteins:General:Carbohydrates, organic alcohols, and acids:Global:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Cofactors and Vitamins:Metabolism:Global:Metabolism:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Poorly characterized" 93 "Uncharacterized conserved protein:Uncharacterized conserved protein:purine-nucleoside phosphorylase activity:Function unknown:Function unknown:Poorly characterized:Poorly characterized" 94 "Adenylosuccinate synthase:Adenylosuccinate synthase:3,4-dihydroxy-2-butanone 4-phosphate synthase:3,4-dihydroxy-2-butanone 4-phosphate synthase:Glycosyltransferases involved in cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:Amino acid transporters:Amino acid transporters:2-methylthioadenine synthetase:2-methylthioadenine synthetase:Holliday junction resolvasome, DNA-binding subunit:Holliday junction resolvasome, DNA-binding subunit:Selenophosphate synthase:Selenophosphate synthase:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Cation/multidrug efflux pump:Cation/multidrug efflux pump:Membrane-fusion protein:Membrane-fusion protein:Predicted GTPases:Predicted GTPases:Outer membrane protein:Outer membrane protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Transcriptional regulators:Transcriptional regulators:Pyrimidine reductase, riboflavin biosynthesis:Pyrimidine reductase, riboflavin biosynthesis:Membrane transporters of cations and cationic drugs:Membrane transporters of cations and cationic drugs:FOG: GGDEF domain:FOG: GGDEF domain:ABC-type proline/glycine betaine transport system, permease component:ABC-type proline/glycine betaine transport system, permease component:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein:Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:GTPase activity:GTP cyclohydrolase II activity:adenylosuccinate synthase activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:selenide, water dikinase activity:transporter activity:protein binding:ATP binding:GTP binding:purine nucleotide biosynthetic process:DNA repair:DNA recombination:regulation of transcription, DNA-dependent:translation:tRNA aminoacylation for protein translation:transport:amino acid transport:chemotaxis:metabolic process:zinc ion binding:lipid binding:protein transporter activity:3,4-dihydroxy-2-butanone-4-phosphate synthase activity:5-amino-6-(5-phosphoribosylamino)uracil reductase activity:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity:cyclic nucleotide biosynthetic process:riboflavin biosynthetic process:protein secretion:four-way junction helicase activity:response to salt stress:ferrous iron transmembrane transporter activity:amino acid transmembrane transporter activity:quaternary-ammonium-compound-transporting ATPase activity:glycine betaine/proline porter activity:ferrous iron transport:phosphorus-oxygen lyase activity:carbon-nitrogen ligase activity, with glutamine as amido-N-donor:2-alkenal reductase [NAD(P)] activity:intracellular signal transduction:cellular protein metabolic process:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Selenocompound metabolism:Selenocompound metabolism:Riboflavin metabolism:Riboflavin metabolism:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00089:TIGR00089:purA:purA:small_GTP:small_GTP:GGDEF:GGDEF:eubact_ribD:eubact_ribD:selD:selD:ribB:ribB:2A0602:2A0602:RND_mfp:RND_mfp:outer_NodT:outer_NodT:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Membrane Transport:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Replication and Repair:Membrane Transport:Signal Transduction:Cell Motility:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:Purine ribonucleotide biosynthesis:Unknown substrate:Porins:General:Riboflavin, FMN, and FAD:Other:Purines, pyrimidines, nucleosides, and nucleotides:Transport and binding proteins:Unknown function:Biosynthesis of cofactors, prosthetic groups, and carriers:Signal transduction:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Transport and binding proteins:Unknown substrate:Porins:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 95 "Tryptophan synthase beta chain:Tryptophan synthase beta chain:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Translation elongation factors (GTPases):Translation elongation factors (GTPases):Biotin synthase and related enzymes:Biotin synthase and related enzymes:Predicted xylanase/chitin deacetylase:Predicted xylanase/chitin deacetylase:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Predicted GTPases:Predicted GTPases:Predicted membrane-associated HD superfamily hydrolase:Predicted membrane-associated HD superfamily hydrolase:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:translation elongation factor activity:catalytic activity:GTPase activity:biotin synthase activity:tryptophan synthase activity:GTP binding:carbohydrate metabolic process:translational elongation:tryptophan metabolic process:metabolic process:protein-synthesizing GTPase activity:biosynthetic process:biotin biosynthetic process:phosphotransferase activity, alcohol group as acceptor:nucleotidyltransferase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:pyridoxal phosphate binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Thiamine metabolism:Thiamine metabolism:Biotin metabolism:Biotin metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:General function prediction only:General function prediction only:cyt_tran_rel:cyt_tran_rel:small_GTP:small_GTP:trpB:trpB:HDIG:HDIG:rSAM_HydG:rSAM_HydG:rSAM_HydE:rSAM_HydE:Amino Acid Metabolism:General:Amino acid biosynthesis:Protein fate:Unknown function:Amino acid biosynthesis:Protein modification and repair:Global:Metabolism:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Protein fate:Protein modification and repair:Unknown function:General:Aromatic amino acid family:Aromatic amino acid family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins" 96 "tRNA and rRNA cytosine-C5-methylases:tRNA and rRNA cytosine-C5-methylases:Predicted permeases:Predicted permeases:Uncharacterized conserved protein:Uncharacterized conserved protein:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:rRNA modification:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:RNA binding:regulation of transcription, DNA-dependent:rRNA methyltransferase activity:protein-glutamate methylesterase activity:sequence-specific DNA binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:Poorly characterized:Cellular processes and signaling:Poorly characterized:Cellular processes and signaling:Information storage and processing:Information storage and processing" 97 "Energy production and conversion:Energy production and conversion:ABC-type phosphate transport system, permease component:ABC-type phosphate transport system, permease component:Rhodanese-related sulfurtransferase:Rhodanese-related sulfurtransferase:Signal transduction histidine kinase:Signal transduction histidine kinase:Endonuclease IV:Endonuclease IV:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:Precorrin-3B methylase:Precorrin-3B methylase:Pyruvate-formate lyase-activating enzyme:Pyruvate-formate lyase-activating enzyme:ATP-utilizing enzymes of the PP-loop superfamily:ATP-utilizing enzymes of the PP-loop superfamily:Predicted esterase of the alpha-beta hydrolase superfamily:Predicted esterase of the alpha-beta hydrolase superfamily:Pyruvate-formate lyase:Pyruvate-formate lyase:Cobalamin biosynthesis protein CbiD:Cobalamin biosynthesis protein CbiD:Chromate transport protein ChrA:Chromate transport protein ChrA:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized conserved protein:Uncharacterized conserved protein:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:thiosulfate sulfurtransferase activity:transporter activity:ATP binding:glucose metabolic process:electron transport:DNA repair:regulation of transcription, DNA-dependent:lipid metabolic process:oxygen and reactive oxygen species metabolic process:transport:signal transduction:transcription factor binding:sulfate transport:deoxyribonuclease IV (phage-T4-induced) activity:formate C-acetyltransferase activity:electron carrier activity:cobalamin biosynthetic process:chromate transmembrane transporter activity:chromate transport:transferase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:methylamine metabolic process:precorrin-3B C17-methyltransferase activity:[formate-C-acetyltransferase]-activating enzyme activity:nutrient reservoir activity:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Butanoate metabolism:Butanoate metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Two-component system:Two-component system:Base excision repair:Base excision repair:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:cbiD:cbiD:nfo:nfo:2A51:2A51:cobJ_cbiH:cobJ_cbiH:C_GCAxxG_C_C:C_GCAxxG_C_C:PFLE_PFLC:PFLE_PFLC:Biosynthesis of cofactors, prosthetic groups, and carriers:Environmental Information Processing:Global:DNA replication, recombination, and repair:Anions:Heme, porphyrin, and cobalamin:DNA metabolism:Transport and binding proteins:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Anions:Genetic Information Processing:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Signal Transduction:Replication and Repair:Metabolism of Cofactors and Vitamins:Carbohydrate Metabolism:Metabolism" 98 "Energy production and conversion:Energy production and conversion:Aspartate oxidase:Aspartate oxidase:1-acyl-sn-glycerol-3-phosphate acyltransferase:1-acyl-sn-glycerol-3-phosphate acyltransferase:Glycosyltransferase:Glycosyltransferase:FKBP-type peptidyl-prolyl cis-trans isomerases 2:FKBP-type peptidyl-prolyl cis-trans isomerases 2:Ferredoxin:Ferredoxin:Transcriptional regulator:Transcriptional regulator:Organic solvent tolerance protein OstA:Organic solvent tolerance protein OstA:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:sequence-specific DNA binding transcription factor activity:peptidyl-prolyl cis-trans isomerase activity:1-acylglycerol-3-phosphate O-acyltransferase activity:cyclophilin:electron transport:regulation of transcription, DNA-dependent:protein folding:sulfotransferase activity:metabolic process:L-aspartate oxidase activity:electron carrier activity:biosynthetic process:NAD biosynthetic process:response to organic substance:cellular membrane organization:specific transcriptional repressor activity:FK506-sensitive peptidyl-prolyl cis-trans isomerase:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:negative regulation of transcription, DNA-dependent:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycerolipid metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Metabolic pathways:Function unknown:Function unknown:nadB:nadB:Lipid Metabolism:Pyridine nucleotides:Global:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism" 99 "Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:ABC-type phosphate transport system, permease component:ABC-type phosphate transport system, permease component:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Predicted permeases:Predicted permeases:FOG: CheY-like receiver:FOG: CheY-like receiver:Esterase/lipase:Esterase/lipase:Sulfur transfer protein involved in thiamine biosynthesis:Sulfur transfer protein involved in thiamine biosynthesis:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):magnesium ion binding:DNA binding:structural constituent of ribosome:catalytic activity:acetolactate synthase activity:carboxylesterase activity:transporter activity:binding:ATP binding:regulation of transcription, DNA-dependent:translation:proteolysis:sulfur compound metabolic process:transport:response to stress:transcription factor binding:metabolic process:serine-type peptidase activity:pyruvate, water dikinase activity:tartronate-semialdehyde synthase activity:branched chain family amino acid biosynthetic process:phosphorylation:amino acid binding:nucleoside-triphosphatase activity:thiamine pyrophosphate binding:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Sulfur relay system:Sulfur relay system:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:acolac_lg:acolac_lg:thiS:thiS:Folding Sorting and Degradation:Metabolism:Global:Metabolism:Cellular processes and signaling:Information storage and processing:Amino acid biosynthesis:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino acid biosynthesis:Thiamine:Pyruvate family:Global:Genetic Information Processing:Metabolism:Metabolism:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Carbohydrate Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Poorly characterized:Genetic Information Processing" 100 "Collagenase and related proteases:Collagenase and related proteases:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Predicted membrane protein:Predicted membrane protein:nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:signal transducer activity:DNA recombination:regulation of transcription, DNA-dependent:proteolysis:chemotaxis:signal transduction:peptidase activity:DNA integration:sequence-specific DNA binding:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:CxxC_CxxC_SSSS:CxxC_CxxC_SSSS:Regulatory functions:Cellular Processes:Cell Motility:DNA interactions:Cellular processes and signaling:Regulatory functions:DNA interactions:Cellular processes and signaling:Poorly characterized:Environmental Information Processing:Cellular Processes:Environmental Information Processing:Poorly characterized:Cell Motility:Signal Transduction:Signal Transduction" 101 "nucleotide binding" 102 "Energy production and conversion:Energy production and conversion:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Integrase:Integrase:Signal transduction histidine kinase:Signal transduction histidine kinase:Chemotaxis protein histidine kinase and related kinases:Chemotaxis protein histidine kinase and related kinases:ABC-type dipeptide transport system, periplasmic component:ABC-type dipeptide transport system, periplasmic component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Heme/copper-type cytochrome/quinol oxidases, subunit 1:Heme/copper-type cytochrome/quinol oxidases, subunit 1:Hemolysins and related proteins containing CBS domains:Hemolysins and related proteins containing CBS domains:FOG: HEAT repeat:FOG: HEAT repeat:ABC-type transport system involved in resistance to organic solvents, periplasmic component:ABC-type transport system involved in resistance to organic solvents, periplasmic component:Uncharacterized enzyme of thiazole biosynthesis:Uncharacterized enzyme of thiazole biosynthesis:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):DNA binding:catalytic activity:cytochrome-c oxidase activity:protein histidine kinase activity:signal transducer activity:ionotropic glutamate receptor activity:transporter activity:extracellular-glutamate-gated ion channel activity:sugar:hydrogen symporter activity:binding:iron ion binding:ATP binding:electron transport:DNA recombination:transport:chemotaxis:signal transduction:metabolic process:biosynthetic process:aerobic respiration:thiamine biosynthetic process:phosphoenolpyruvate-dependent sugar phosphotransferase system:aa3-type cytochrome c oxidase:ba3-type cytochrome c oxidase:caa3-type cytochrome c oxidase:cbb3-type cytochrome c oxidase:DNA integration:kinase activity:transferase activity, transferring nitrogenous groups:peptidyl-histidine phosphorylation:heme binding:pyridoxal phosphate binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Oxidative phosphorylation:Oxidative phosphorylation:Thiamine metabolism:Thiamine metabolism:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:CtaD_CoxA:CtaD_CoxA:Membrane Transport:Energy Metabolism:Metabolism of Cofactors and Vitamins:Membrane Transport:Signal Transduction:Cell Motility:Metabolism:Metabolism:Environmental Information Processing:Cellular Processes:Global:Electron transport:Small molecule interactions:Energy metabolism:Regulatory functions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Electron transport:Regulatory functions:Small molecule interactions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 103 "Energy production and conversion:Energy production and conversion:3-isopropylmalate dehydratase large subunit:3-isopropylmalate dehydratase large subunit:3-isopropylmalate dehydratase small subunit:3-isopropylmalate dehydratase small subunit:Isopropylmalate/homocitrate/citramalate synthases:Isopropylmalate/homocitrate/citramalate synthases:Isocitrate/isopropylmalate dehydrogenase:Isocitrate/isopropylmalate dehydrogenase:Phosphatidylserine decarboxylase:Phosphatidylserine decarboxylase:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Membrane protein TerC, possibly involved in tellurium resistance:Membrane protein TerC, possibly involved in tellurium resistance:Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases:Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized FAD-dependent dehydrogenases:Uncharacterized FAD-dependent dehydrogenases:Amino acid transport and metabolism:Amino acid transport and metabolism:2-isopropylmalate synthase activity:3-isopropylmalate dehydratase activity:3-isopropylmalate dehydrogenase activity:phosphatidylserine decarboxylase activity:signal transducer activity:binding:chemotaxis:signal transduction:phospholipid biosynthetic process:leucine biosynthetic process:thiamine biosynthetic process:carbohydrate biosynthetic process:oxidoreductase activity:transferase activity, transferring hexosyl groups:(R)-2-methylmalate dehydratase activity:4 iron, 4 sulfur cluster binding:Lipid transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Pyruvate metabolism:Pyruvate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:PS_decarb_rel:PS_decarb_rel:leuB:leuB:leuA_bact:leuA_bact:hacA_fam:hacA_fam:LEUD_arch:LEUD_arch:R_switched_Alx:R_switched_Alx:Cellular processes and signaling:Unknown function:General:Amino acid biosynthesis:Pyruvate family:Cellular processes and signaling:Metabolism:Poorly characterized:Amino acid biosynthesis:Unknown function:Pyruvate family:General:Global:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Amino Acid Metabolism:Lipid Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism:Environmental Information Processing:Signal Transduction:Poorly characterized:Cellular Processes:Cell Motility:Metabolism:Global:Metabolism" 104 "Molecular chaperone (small heat shock protein):Molecular chaperone (small heat shock protein):Co-chaperonin GroES (HSP10):Co-chaperonin GroES (HSP10):Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Molecular chaperone, HSP90 family:Molecular chaperone, HSP90 family:Molecular chaperone:Molecular chaperone:Chaperonin GroEL (HSP60 family):Chaperonin GroEL (HSP60 family):Zn-dependent hydrolases, including glyoxylases:Zn-dependent hydrolases, including glyoxylases:Predicted Zn-dependent peptidases:Predicted Zn-dependent peptidases:Uncharacterized conserved protein:Uncharacterized conserved protein:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:two-component response regulator activity:two-component signal transduction system (phosphorelay):chaperonin ATPase activity:metalloendopeptidase activity:serine-type endopeptidase activity:protein binding:ATP binding:regulation of transcription, DNA-dependent:protein folding:proteolysis:chemotaxis:zinc ion binding:protein-glutamate methylesterase activity:hydrolase activity:2-alkenal reductase [NAD(P)] activity:cellular protein metabolic process:unfolded protein binding:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:RNA degradation:RNA degradation:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:degP_htrA_DO:degP_htrA_DO:GroEL:GroEL:prok_dnaK:prok_dnaK:Protein fate:Protein folding and stabilization:Degradation of proteins, peptides, and glycopeptides:Cellular processes and signaling:Poorly characterized:Signal Transduction:Cellular processes and signaling:Environmental Information Processing:Protein fate:Degradation of proteins, peptides, and glycopeptides:Protein folding and stabilization:Cellular Processes:Environmental Information Processing:Genetic Information Processing:Cell Motility:Signal Transduction:Folding Sorting and Degradation:Cellular Processes:Genetic Information Processing:Cell Motility:Poorly characterized:Folding Sorting and Degradation" 105 "Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Signal transduction histidine kinase:Signal transduction histidine kinase:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Pyruvate-formate lyase-activating enzyme:Pyruvate-formate lyase-activating enzyme:N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains):N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains):Flagellar motor component:Flagellar motor component:Uncharacterized conserved protein:Uncharacterized conserved protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized protein, homolog of phage Mu protein gp30:Uncharacterized protein, homolog of phage Mu protein gp30:Predicted HD-superfamily hydrolase:Predicted HD-superfamily hydrolase:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Mu-like prophage protein gpG:Mu-like prophage protein gpG:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:nucleic acid binding:sequence-specific DNA binding transcription factor activity:motor activity:catalytic activity:UDP-N-acetylglucosamine diphosphorylase activity:acetyl-CoA:L-glutamate N-acetyltransferase activity:diamine N-acetyltransferase activity:metalloendopeptidase activity:protein histidine kinase activity:signal transducer activity:ATP binding:carbohydrate metabolic process:regulation of transcription, DNA-dependent:proteolysis:Mo-molybdopterin cofactor biosynthetic process:transport:chemotaxis:response to stress:signal transduction:transcription factor binding:metabolic process:zinc ion binding:isoprenoid biosynthetic process:protein transporter activity:lipopolysaccharide biosynthetic process:pathogenesis:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:glucosamine-1-phosphate N-acetyltransferase activity:[formate-C-acetyltransferase]-activating enzyme activity:regulation of protein secretion:iron-sulfur cluster binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Metabolic pathways:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Sulfur relay system:Sulfur relay system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:HDIG:HDIG:glmU:glmU:tail_comp_S:tail_comp_S:phageSPP1_gp7:phageSPP1_gp7:Poorly characterized:Cell Motility:Signal Transduction:Folding Sorting and Degradation:Carbohydrate Metabolism:Metabolism:Regulatory functions:Environmental Information Processing:Cellular Processes:Global:Amino sugars:Small molecule interactions:Prophage functions:Central intermediary metabolism:Regulatory functions:Mobile and extrachromosomal element functions:Metabolism:Cellular processes and signaling:Poorly characterized:Metabolism:Carbohydrate Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Amino sugars:Genetic Information Processing:Small molecule interactions:Mobile and extrachromosomal element functions:Prophage functions:Cellular processes and signaling" 106 "Energy production and conversion:Energy production and conversion:Succinyl-CoA synthetase, beta subunit:Succinyl-CoA synthetase, beta subunit:Permeases of the drug/metabolite transporter (DMT) superfamily:Permeases of the drug/metabolite transporter (DMT) superfamily:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Ferredoxin:Ferredoxin:N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains):N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains):Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Bacteriophage capsid protein:Bacteriophage capsid protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:UDP-N-acetylglucosamine diphosphorylase activity:acetyl-CoA:L-glutamate N-acetyltransferase activity:diamine N-acetyltransferase activity:succinate-CoA ligase (ADP-forming) activity:ATP binding:electron transport:regulation of transcription, DNA-dependent:chemotaxis:transcription factor binding:metabolic process:isoprenoid biosynthetic process:electron carrier activity:lipopolysaccharide biosynthetic process:ATPase activity:nucleoside-triphosphatase activity:glucosamine-1-phosphate N-acetyltransferase activity:iron-sulfur cluster binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Propanoate metabolism:Propanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sucCoAalpha:sucCoAalpha:glmU:glmU:portal_lambda:portal_lambda:Carbohydrate Metabolism:TCA cycle:Amino sugars:Prophage functions:Central intermediary metabolism:Energy metabolism:Mobile and extrachromosomal element functions:Global:Environmental Information Processing:Metabolism:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Amino sugars:Energy metabolism:TCA cycle:Mobile and extrachromosomal element functions:Prophage functions:Cellular processes and signaling:Metabolism:Poorly characterized:Membrane Transport" 107 "Energy production and conversion:Energy production and conversion:Predicted GTPase:Predicted GTPase:Uncharacterized phage-encoded protein:Uncharacterized phage-encoded protein:Thiol:disulfide interchange protein:Thiol:disulfide interchange protein:catalytic activity:glycerol ether metabolic process:electron carrier activity:protein disulfide oxidoreductase activity:cytochrome complex assembly:cell redox homeostasis:protein-disulfide reductase activity:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:General function prediction only:General function prediction only:Function unknown:Function unknown:phage_pRha:phage_pRha:Cellular processes and signaling:Metabolism:Poorly characterized:Poorly characterized:Mobile and extrachromosomal element functions:Cellular processes and signaling:Prophage functions:Mobile and extrachromosomal element functions:Metabolism:Prophage functions" 108 "" 109 "Predicted Co/Zn/Cd cation transporters:Predicted Co/Zn/Cd cation transporters:Hydrogenase maturation factor:Hydrogenase maturation factor:Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Predicted permeases:Predicted permeases:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):ABC-type transport system involved in resistance to organic solvents, ATPase component:ABC-type transport system involved in resistance to organic solvents, ATPase component:ADP-ribosylglycohydrolase:ADP-ribosylglycohydrolase:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Multidrug resistance efflux pump:Multidrug resistance efflux pump:Sec-independent protein secretion pathway components:Sec-independent protein secretion pathway components:ABC-type proline/glycine betaine transport systems, periplasmic components:ABC-type proline/glycine betaine transport systems, periplasmic components:FOG: HPt domain:FOG: HPt domain:Lysophospholipase L1 and related esterases:Lysophospholipase L1 and related esterases:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:catalytic activity:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity:transporter activity:sugar:hydrogen symporter activity:binding:calcium ion binding:ATP binding:electron transport:lipid metabolic process:transport:cation transport:response to stress:metabolic process:cation transmembrane transporter activity:protein transporter activity:phospholipid biosynthetic process:cardiolipin synthase activity:phosphoenolpyruvate-protein phosphotransferase activity:electron carrier activity:protein secretion:phosphoenolpyruvate-dependent sugar phosphotransferase system:protein transport:phosphorylation:hydrolase activity, acting on ester bonds:ATPase activity:Lipid transport and metabolism:Lipid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Fructose and mannose metabolism:Fatty acid biosynthesis:Fatty acid biosynthesis:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Biosynthesis of unsaturated fatty acids:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:Phosphotransferase system (PTS):Phosphotransferase system (PTS):Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:hypC_hupF:hypC_hupF:PTS_HPr_family:PTS_HPr_family:CDF:CDF:tatAE:tatAE:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Cations and iron carrying compounds:Environmental Information Processing:Global:Protein and peptide secretion and trafficking:Protein modification and repair:Cations and iron carrying compounds:PTS:Protein fate:Transport and binding proteins:Signal transduction:Metabolism:Membrane Transport:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Transport and binding proteins:Genetic Information Processing:Signal transduction:PTS:Cellular processes and signaling:Metabolism:Poorly characterized:Folding Sorting and Degradation:Lipid Metabolism:Carbohydrate Metabolism:Metabolism" 110 "Energy production and conversion:Energy production and conversion:Arginase/agmatinase/formimionoglutamate hydrolase, arginase family:Arginase/agmatinase/formimionoglutamate hydrolase, arginase family:Dihydroorotate dehydrogenase:Dihydroorotate dehydrogenase:Lactoylglutathione lyase and related lyases:Lactoylglutathione lyase and related lyases:Thiamine monophosphate synthase:Thiamine monophosphate synthase:Predicted transcriptional regulators:Predicted transcriptional regulators:Predicted permeases:Predicted permeases:1-deoxy-D-xylulose 5-phosphate reductoisomerase:1-deoxy-D-xylulose 5-phosphate reductoisomerase:Nitroreductase:Nitroreductase:Alanine racemase:Alanine racemase:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Membrane-fusion protein:Membrane-fusion protein:Acyl carrier protein phosphodiesterase:Acyl carrier protein phosphodiesterase:DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog:DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog:Outer membrane protein:Outer membrane protein:Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:Putative NADPH-quinone reductase (modulator of drug activity B):Putative NADPH-quinone reductase (modulator of drug activity B):Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:dihydroorotate dehydrogenase activity:dihydroorotate oxidase activity:dihydrouracil dehydrogenase (NAD+) activity:thiamine-phosphate diphosphorylase activity:signal transducer activity:transporter activity:binding:GTP binding:electron transport:'de novo' pyrimidine base biosynthetic process:UMP biosynthetic process:nucleotide-excision repair:transcription initiation, DNA-dependent:regulation of transcription, DNA-dependent:alanine metabolic process:polyamine biosynthetic process:cellular aromatic compound metabolic process:chemotaxis:microtubule-based process:signal transduction:ferrous iron binding:isoprenoid biosynthetic process:protein transporter activity:[acyl-carrier-protein] phosphodiesterase activity:agmatinase activity:alanine racemase activity:thiamine biosynthetic process:protein secretion:excinuclease ABC activity:protein transport:oxidoreductase activity:sigma factor activity:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity:sequence-specific DNA binding:metal ion binding:coenzyme binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Pyrimidine metabolism:Pyrimidine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:D-Alanine metabolism:D-Alanine metabolism:Thiamine metabolism:Thiamine metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:RNA polymerase:RNA polymerase:Nucleotide excision repair:Nucleotide excision repair:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:uvrC:uvrC:Dxr:Dxr:alr:alr:thiE:thiE:pyrD_sub1_fam:pyrD_sub1_fam:agmatinase:agmatinase:RND_mfp:RND_mfp:type_I_sec_TolC:type_I_sec_TolC:chp_urease_rgn:chp_urease_rgn:rpoN_sigma:rpoN_sigma:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Porins:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Thiamine:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:DNA replication, recombination, and repair:Transcription factors:Unknown substrate:Porins:Conserved:Other:Thiamine:Biosynthesis and degradation of murein sacculus and peptidoglycan:DNA metabolism:Transcription:Transport and binding proteins:Hypothetical proteins:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Cell Motility:Signal Transduction:Replication and Repair:Transcription:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Transcription:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Transport and binding proteins:Unknown substrate" 111 "HD superfamily phosphohydrolases:HD superfamily phosphohydrolases:Micrococcal nuclease (thermonuclease) homologs:Micrococcal nuclease (thermonuclease) homologs:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Uncharacterized conserved protein:Uncharacterized conserved protein:two-component sensor activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:nuclease activity:endonuclease activity:ATP binding:DNA modification:DNA methylation:regulation of transcription, DNA-dependent:response to osmotic stress:transcription factor binding:methyltransferase activity:N-methyltransferase activity:Type II site-specific deoxyribonuclease activity:DNA restriction-modification system:nucleoside-triphosphatase activity:methylation:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:Poorly characterized:Poorly characterized:Cellular processes and signaling:Information storage and processing:Information storage and processing:Small molecule interactions:Regulatory functions:Small molecule interactions:Regulatory functions:Cellular processes and signaling" 112 "Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:SAM-dependent methyltransferases:SAM-dependent methyltransferases:Signal transduction histidine kinase:Signal transduction histidine kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Predicted glycosyltransferases:Predicted glycosyltransferases:Peroxiredoxin:Peroxiredoxin:FOG: PAS/PAC domain:FOG: PAS/PAC domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:ABC-type phosphate/phosphonate transport system, periplasmic component:ABC-type phosphate/phosphonate transport system, periplasmic component:DNA uptake lipoprotein:DNA uptake lipoprotein:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Predicted membrane protein:Predicted membrane protein:Mu-like prophage host-nuclease inhibitor protein Gam:Mu-like prophage host-nuclease inhibitor protein Gam:Membrane-bound metallopeptidase:Membrane-bound metallopeptidase:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:metalloendopeptidase activity:endonuclease activity:signal transducer activity:binding:ATP binding:carbohydrate metabolic process:regulation of transcription, DNA-dependent:proteolysis:Mo-molybdopterin cofactor biosynthetic process:signal transduction:transcription factor binding:metabolic process:methyltransferase activity:zinc ion binding:lipid biosynthetic process:cyclopropane-fatty-acyl-phospholipid synthase activity:phosphonate transmembrane transporter activity:phosphonate transport:transcription repressor activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:pyridoxal phosphate binding:negative regulation of transcription, DNA-dependent:peroxiredoxin activity:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyruvate metabolism:Pyruvate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Sulfur relay system:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:Environmental Information Processing:Regulatory functions:Small molecule interactions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Folding Sorting and Degradation:Genetic Information Processing:Energy Metabolism:Carbohydrate Metabolism:Metabolism:Signal Transduction:Metabolism:Cellular processes and signaling:Information storage and processing:Regulatory functions:Small molecule interactions:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Signal Transduction:Membrane Transport:Folding Sorting and Degradation:Energy Metabolism:Carbohydrate Metabolism:Poorly characterized:Global:Metabolism:Membrane Transport" 113 "Energy production and conversion:Energy production and conversion:Glutamyl- and glutaminyl-tRNA synthetases:Glutamyl- and glutaminyl-tRNA synthetases:ATP phosphoribosyltransferase:ATP phosphoribosyltransferase:Histidyl-tRNA synthetase:Histidyl-tRNA synthetase:Phosphoribosyl-AMP cyclohydrolase:Phosphoribosyl-AMP cyclohydrolase:Histidinol dehydrogenase:Histidinol dehydrogenase:Aspartyl-tRNA synthetase:Aspartyl-tRNA synthetase:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Enoyl-[acyl-carrier-protein] reductase (NADH):Enoyl-[acyl-carrier-protein] reductase (NADH):UDP-3-O-acyl-N-acetylglucosamine deacetylase:UDP-3-O-acyl-N-acetylglucosamine deacetylase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Sec-independent protein secretion pathway components:Sec-independent protein secretion pathway components:Predicted membrane protein:Predicted membrane protein:Methylase of polypeptide chain release factors:Methylase of polypeptide chain release factors:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:ABC-type arginine/histidine transport system, permease component:ABC-type arginine/histidine transport system, permease component:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:histidine biosynthetic process:nucleic acid binding:sequence-specific DNA binding transcription factor activity:catalytic activity:ATP phosphoribosyltransferase activity:enoyl-[acyl-carrier-protein] reductase (NADH) activity:enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity:histidinol dehydrogenase activity:phosphoribosyl-AMP cyclohydrolase activity:phosphoribosyl-ATP diphosphatase activity:aspartate-tRNA ligase activity:glutamate-tRNA ligase activity:histidine-tRNA ligase activity:phenylalanine-tRNA ligase activity:transporter activity:ATP binding:electron transport:regulation of transcription, DNA-dependent:aspartyl-tRNA aminoacylation:glutamyl-tRNA aminoacylation:histidyl-tRNA aminoacylation:phenylalanyl-tRNA aminoacylation:protein methylation:fatty acid biosynthetic process:transport:transcription factor binding:metabolic process:zinc ion binding:protein methyltransferase activity:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity:cobalamin biosynthetic process:lipid A biosynthetic process:protein secretion:protein transport:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:nucleoside-triphosphatase activity:L-malate dehydrogenase activity:cobyrinic acid a,c-diamide synthase activity:indolepyruvate ferredoxin oxidoreductase activity:NAD binding:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Fatty acid biosynthesis:Fatty acid biosynthesis:Histidine metabolism:Histidine metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Flagellar assembly:Flagellar assembly:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:hisD:hisD:hisG:hisG:lpxC:lpxC:hisS:hisS:aspS_bact:aspS_bact:gltX_bact:gltX_bact:hemK_fam:hemK_fam:tatB:tatB:HEQRo_perm_3TM:HEQRo_perm_3TM:hyd_TM1266:hyd_TM1266:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Protein modification and repair:Transport and binding proteins:Amino acids, peptides and amines:Amino acid biosynthesis:Histidine family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Folding Sorting and Degradation:Translation:Membrane Transport:Cell Motility:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:DNA interactions:tRNA aminoacylation:Protein and peptide secretion and trafficking:Protein modification and repair:Amino acids, peptides and amines:Histidine family:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Regulatory functions:Protein synthesis:Protein fate:Transport and binding proteins:Amino acid biosynthesis:Cell envelope:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Lipid Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Lipid Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:DNA interactions:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking" 114 "Molecular chaperone (small heat shock protein):Molecular chaperone (small heat shock protein):ATP-dependent Lon protease, bacterial type:ATP-dependent Lon protease, bacterial type:Zn-dependent protease with chaperone function:Zn-dependent protease with chaperone function:Predicted Zn-dependent peptidases:Predicted Zn-dependent peptidases:Predicted hydrolase (HAD superfamily):Predicted hydrolase (HAD superfamily):Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:ATP-dependent peptidase activity:metalloendopeptidase activity:ATP binding:proteolysis:ATP-dependent proteolysis:metabolic process:zinc ion binding:endopeptidase La activity:hydrolase activity:nucleoside-triphosphatase activity:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:unchar_dom_1:unchar_dom_1:lon:lon:Poorly characterized:Metabolism:Cellular processes and signaling:Degradation of proteins, peptides, and glycopeptides:Protein fate:Poorly characterized:Metabolism:Cellular processes and signaling:Protein fate:Degradation of proteins, peptides, and glycopeptides" 115 "Energy production and conversion:Energy production and conversion:6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase:6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase:Ketopantoate hydroxymethyltransferase:Ketopantoate hydroxymethyltransferase:Translation elongation factors (GTPases):Translation elongation factors (GTPases):2-methylthioadenine synthetase:2-methylthioadenine synthetase:Signal transduction histidine kinase:Signal transduction histidine kinase:BioD-like N-terminal domain of phosphotransacetylase:BioD-like N-terminal domain of phosphotransacetylase:Flavodoxin reductases (ferredoxin-NADPH reductases) family 1:Flavodoxin reductases (ferredoxin-NADPH reductases) family 1:Flagellar motor switch/type III secretory pathway protein:Flagellar motor switch/type III secretory pathway protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted HD-superfamily hydrolase:Predicted HD-superfamily hydrolase:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:nucleic acid binding:sequence-specific DNA binding transcription factor activity:motor activity:catalytic activity:3-methyl-2-oxobutanoate hydroxymethyltransferase activity:GTPase activity:ATP-dependent peptidase activity:calcium ion binding:ATP binding:GTP binding:pentose-phosphate shunt:electron transport:regulation of transcription, DNA-dependent:translation:proteolysis:chemotaxis:signal transduction:transcription factor binding:metabolic process:protein-synthesizing GTPase activity:endopeptidase La activity:response to external stimulus:pantothenate biosynthetic process:oxidoreductase activity:6-phosphogluconolactonase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:carbohydrate binding:2-alkenal reductase [NAD(P)] activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Pentose phosphate pathway:Pentose phosphate pathway:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00089:TIGR00089:panB:panB:sensory_box:sensory_box:HDIG:HDIG:pgl:pgl:fliN:fliN:PEP_exosort:PEP_exosort:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Global:Cell Motility:Cellular Processes:Energy metabolism:Pentose phosphate pathway:Regulatory functions:Small molecule interactions:Cellular processes:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Cell envelope:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cellular Processes:Metabolism:Metabolism of Cofactors and Vitamins:Metabolism:Carbohydrate Metabolism:Regulatory functions:Cell Motility:Metabolism of Cofactors and Vitamins:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Global:Pentose phosphate pathway:Small molecule interactions:Chemotaxis and motility:Pantothenate and coenzyme A:Surface structures:Cell envelope:Biosynthesis of cofactors, prosthetic groups, and carriers:Cellular processes:Energy metabolism" 116 "Anthranilate/para-aminobenzoate synthases component II:Anthranilate/para-aminobenzoate synthases component II:Ca2+/Na+ antiporter:Ca2+/Na+ antiporter:Membrane protein TerC, possibly involved in tellurium resistance:Membrane protein TerC, possibly involved in tellurium resistance:Phosphate transport regulator (distant homolog of PhoU):Phosphate transport regulator (distant homolog of PhoU):Amino acid transport and metabolism:Amino acid transport and metabolism:anthranilate synthase activity:glutamine metabolic process:biosynthetic process:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Folate biosynthesis:Folate biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:R_switched_Alx:R_switched_Alx:Amino Acid Metabolism:Metabolism:Global:Metabolism:Metabolism:Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins" 117 "Aspartyl/asparaginyl-tRNA synthetases:Aspartyl/asparaginyl-tRNA synthetases:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Thymidylate kinase:Thymidylate kinase:Trk-type K+ transport systems, membrane components:Trk-type K+ transport systems, membrane components:Superfamily I DNA and RNA helicases:Superfamily I DNA and RNA helicases:Hydrogenase maturation factor:Hydrogenase maturation factor:Predicted metal-dependent hydrolase:Predicted metal-dependent hydrolase:Glutamyl-tRNA reductase:Glutamyl-tRNA reductase:Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase:Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase:Zn-dependent hydrolases, including glyoxylases:Zn-dependent hydrolases, including glyoxylases:Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:Signal transduction histidine kinase:Signal transduction histidine kinase:ABC-type transport system involved in cytochrome c biogenesis, permease component:ABC-type transport system involved in cytochrome c biogenesis, permease component:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:Predicted nucleoside-diphosphate sugar epimerase:Predicted nucleoside-diphosphate sugar epimerase:ATPase components of various ABC-type transport systems, contain duplicated ATPase:ATPase components of various ABC-type transport systems, contain duplicated ATPase:Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain):Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain):Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized protein related to Endonuclease III:Uncharacterized protein related to Endonuclease III:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):magnesium ion binding:nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA-(apurinic or apyrimidinic site) lyase activity:hydrogen-transporting two-sector ATPase activity:acetolactate synthase activity:ATP-dependent DNA helicase activity:aspartic-type endopeptidase activity:hydroxyacylglutathione hydrolase activity:shikimate 3-dehydrogenase (NADP+) activity:thymidylate kinase activity:aspartate-tRNA ligase activity:asparagine-tRNA ligase activity:transporter activity:binding:ATP binding:electron transport:dTDP biosynthetic process:dTTP biosynthetic process:DNA repair:base-excision repair:mismatch repair:regulation of transcription, DNA-dependent:asparaginyl-tRNA aminoacylation:aspartyl-tRNA aminoacylation:protein complex assembly:proteolysis:porphyrin-containing compound biosynthetic process:transport:cation transport:signal transduction:transcription factor binding:metabolic process:respiratory chain complex IV assembly:glutamyl-tRNA reductase activity:thiamine-phosphate kinase activity:branched chain family amino acid biosynthetic process:valine biosynthetic process:nickel ion binding:oxidoreductase activity:transferase activity:hydrolase activity:ATPase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:thiamine pyrophosphate binding:mismatched DNA binding:tetrapyrrole biosynthetic process:sequence-specific DNA binding:cellular metabolic process:hydrogen ion transporting ATP synthase activity, rotational mechanism:proton-transporting ATPase activity, rotational mechanism:flavin adenine dinucleotide binding:NADP binding:coenzyme binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Nucleotide excision repair:Nucleotide excision repair:Mismatch repair:Mismatch repair:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:DTMP_kinase:DTMP_kinase:TIGR00043:TIGR00043:hypB:hypB:acolac_lg:acolac_lg:asnS:asnS:hemA:hemA:cysG_Nterm:cysG_Nterm:yfcH:yfcH:hypE:hypE:Poorly characterized:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Genetic Information Processing:Protein fate:Global:Nucleotide and nucleoside interconversions:Other:tRNA aminoacylation:Protein modification and repair:Conserved:Pyruvate family:Heme, porphyrin, and cobalamin:Purines, pyrimidines, nucleosides, and nucleotides:Protein synthesis:Protein fate:Hypothetical proteins:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Metabolism:Membrane Transport:Replication and Repair:Translation:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Protein synthesis:Other:tRNA aminoacylation:Environmental Information Processing:Protein modification and repair:Hypothetical proteins:Conserved:Amino acid biosynthesis:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism" 118 "Type I site-specific restriction-modification system, R (restriction) subunit and related helicases:Type I site-specific restriction-modification system, R (restriction) subunit and related helicases:DNA modification methylase:DNA modification methylase:Aspartate ammonia-lyase:Aspartate ammonia-lyase:Predicted metal-dependent hydrolase:Predicted metal-dependent hydrolase:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted membrane protein:Predicted membrane protein:ABC-type uncharacterized transport system, auxiliary component:ABC-type uncharacterized transport system, auxiliary component:Amino acid transport and metabolism:Amino acid transport and metabolism:nucleotide binding:DNA binding:iron ion transmembrane transporter activity:ATP binding:fumarate metabolic process:DNA methylation:proteolysis:aspartate metabolic process:iron ion transport:N-methyltransferase activity:metallopeptidase activity:zinc ion binding:protein transporter activity:aspartate ammonia-lyase activity:site-specific DNA-methyltransferase (adenine-specific) activity:Type I site-specific deoxyribonuclease activity:DNA restriction-modification system:protein transport:Replication, recombination and repair:Replication, recombination and repair:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:General function prediction only:General function prediction only:Function unknown:Function unknown:hsdR:hsdR:tonB_Cterm:tonB_Cterm:Defense mechanisms:Defense mechanisms:Energy Metabolism:Global:Metabolism:Metabolism:Poorly characterized:Metabolism:DNA metabolism:Restriction/modification:Transport and binding proteins:Cations and iron carrying compounds:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cellular processes and signaling:Energy Metabolism:Information storage and processing:Transport and binding proteins:DNA metabolism:Cations and iron carrying compounds:Restriction/modification:Global:Metabolism:Metabolism:Amino Acid Metabolism:Amino Acid Metabolism" 119 "Energy production and conversion:Energy production and conversion:ABC-type phosphate transport system, periplasmic component:ABC-type phosphate transport system, periplasmic component:Uncharacterized conserved protein:Uncharacterized conserved protein:Glycosyltransferase:Glycosyltransferase:Na+-driven multidrug efflux pump:Na+-driven multidrug efflux pump:Organic radical activating enzymes:Organic radical activating enzymes:Predicted PP-loop superfamily ATPase:Predicted PP-loop superfamily ATPase:Rhodanese-related sulfurtransferase:Rhodanese-related sulfurtransferase:Predicted sugar phosphate isomerase involved in capsule formation:Predicted sugar phosphate isomerase involved in capsule formation:Holliday junction resolvasome, endonuclease subunit:Holliday junction resolvasome, endonuclease subunit:UDP-glucose 4-epimerase:UDP-glucose 4-epimerase:Arginine decarboxylase (spermidine biosynthesis):Arginine decarboxylase (spermidine biosynthesis):ATP-dependent protease HslVU (ClpYQ), ATPase subunit:ATP-dependent protease HslVU (ClpYQ), ATPase subunit:Acylphosphatases:Acylphosphatases:Acyl-CoA hydrolase:Acyl-CoA hydrolase:Acetyltransferases, including N-acetylases of ribosomal proteins:Acetyltransferases, including N-acetylases of ribosomal proteins:Saccharopine dehydrogenase and related proteins:Saccharopine dehydrogenase and related proteins:Arylsulfatase A and related enzymes:Arylsulfatase A and related enzymes:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID:Uncharacterized conserved protein:Uncharacterized conserved protein:Bacteriophage tail assembly protein:Bacteriophage tail assembly protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:nucleic acid binding:DNA binding:catalytic activity:DNA-directed DNA polymerase activity:UDP-glucose 4-epimerase activity:acylphosphatase activity:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity:thiosulfate sulfurtransferase activity:protein binding:ATP binding:sugar binding:carbohydrate metabolic process:DNA replication:DNA repair:DNA recombination:arginine catabolic process:transport:drug transmembrane transport:metabolic process:sulfate transport:spermidine biosynthetic process:endopeptidase Clp activity:sulfuric ester hydrolase activity:arginine decarboxylase activity:crossover junction endodeoxyribonuclease activity:dTDP-4-dehydrorhamnose reductase activity:ribosomal-protein-alanine N-acetyltransferase activity:biosynthetic process:lysine biosynthetic process:HslUV protease activity:phosphoenolpyruvate-dependent sugar phosphotransferase system:drug transmembrane transporter activity:antiporter activity:ATPase activity:lipoate-protein ligase activity:arabinose-5-phosphate isomerase activity:heme binding:cellular metabolic process:extracellular polysaccharide biosynthetic process:transition metal ion binding:coenzyme binding:iron-sulfur cluster binding:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Fructose and mannose metabolism:Galactose metabolism:Galactose metabolism:Lysine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Pyruvate metabolism:Limonene and pinene degradation:Limonene and pinene degradation:Biosynthesis of unsaturated fatty acids:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Phosphotransferase system (PTS):Phosphotransferase system (PTS):Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Function unknown:Function unknown:ruvC:ruvC:TIGR00364:TIGR00364:hslU:hslU:kpsF:kpsF:matE:matE:speA:speA:ptsS_2:ptsS_2:Defense mechanisms:Defense mechanisms:Replication and Repair:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Central intermediary metabolism:Polyamine biosynthesis:Energy metabolism:Sugars:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein folding and stabilization:Transport and binding proteins:Anions:Other:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Unknown function:Transport and binding proteins:Protein fate:DNA metabolism:Energy metabolism:Central intermediary metabolism:Carbohydrate Metabolism:General:Other:Anions:Protein folding and stabilization:DNA replication, recombination, and repair:Sugars:Polyamine biosynthesis:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Signal Transduction:Membrane Transport:Replication and Repair:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Lipid Metabolism:Membrane Transport:Signal Transduction:Global:Metabolism:Environmental Information Processing" 120 "Arginase/agmatinase/formimionoglutamate hydrolase, arginase family:Arginase/agmatinase/formimionoglutamate hydrolase, arginase family:ATP-dependent Zn proteases:ATP-dependent Zn proteases:Na+-driven multidrug efflux pump:Na+-driven multidrug efflux pump:Uncharacterized membrane protein (homolog of Drosophila rhomboid):Uncharacterized membrane protein (homolog of Drosophila rhomboid):Serine acetyltransferase:Serine acetyltransferase:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:ATP-dependent protease Clp, ATPase subunit:ATP-dependent protease Clp, ATPase subunit:Nitrate/nitrite transporter:Nitrate/nitrite transporter:Protein affecting phage T7 exclusion by the F plasmid:Protein affecting phage T7 exclusion by the F plasmid:Amino acid transport and metabolism:Amino acid transport and metabolism:metalloendopeptidase activity:transporter activity:ATP binding:GTP binding:DNA repair:DNA recombination:proteolysis:cysteine biosynthetic process from serine:polyamine biosynthetic process:transport:drug transmembrane transport:microtubule-based process:metabolic process:zinc ion binding:endopeptidase Clp activity:transaminase activity:agmatinase activity:serine O-acetyltransferase activity:four-way junction helicase activity:protein transport:drug transmembrane transporter activity:antiporter activity:ATPase activity:nucleoside-triphosphatase activity:protein metabolic process:protein catabolic process:pyridoxal phosphate binding:cysteine desulfurase activity:metal ion binding:protein dimerization activity:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Thiamine metabolism:Thiamine metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Sulfur relay system:Sulfur relay system:General function prediction only:General function prediction only:clpX:clpX:matE:matE:agmatinase:agmatinase:FtsH_fam:FtsH_fam:FeS_nifS:FeS_nifS:Defense mechanisms:Defense mechanisms:Poorly characterized:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Folding Sorting and Degradation:Metabolism:Metabolism:Genetic Information Processing:Global:Degradation of proteins, peptides, and glycopeptides:Other:Protein fate:Transport and binding proteins:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Global:Metabolism:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Other:Cellular processes and signaling:Metabolism" 121 "Site-specific DNA methylase:Site-specific DNA methylase:Glycosyltransferase:Glycosyltransferase:Uncharacterized membrane-associated protein:Uncharacterized membrane-associated protein:Uncharacterized protein predicted to be involved in DNA repair:Uncharacterized protein predicted to be involved in DNA repair:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Predicted HD superfamily hydrolase:Predicted HD superfamily hydrolase:Isochorismate hydrolase:Isochorismate hydrolase:Predicted signal transduction protein:Predicted signal transduction protein:Sec-independent protein secretion pathway components:Sec-independent protein secretion pathway components:Transposase and inactivated derivatives:Transposase and inactivated derivatives:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Transposase and inactivated derivatives:Transposase and inactivated derivatives:Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain:Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:RNA binding:structural constituent of ribosome:catalytic activity:DNA (cytosine-5-)-methyltransferase activity:cysteine-type endopeptidase activity:transposase activity:GTP binding:DNA methylation:transposition, DNA-mediated:regulation of transcription, DNA-dependent:translation:proteolysis:metabolic process:isochorismatase activity:biosynthetic process:cyclic nucleotide biosynthetic process:protein secretion:protein transport:DNA integration:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:transferase activity, transferring acyl groups other than amino-acyl groups:phosphorus-oxygen lyase activity:intracellular signal transduction:antisigma factor binding:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:HDIG:HDIG:ant_ant_sig:ant_ant_sig:dcm:dcm:tatAE:tatAE:autotrans_barl:autotrans_barl:cas2:cas2:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Amino Acid Metabolism:Metabolism:Poorly characterized:Metabolism:Regulatory functions:Protein interactions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Pathogenesis:Mobile and extrachromosomal element functions:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing:Mobile and extrachromosomal element functions:Cellular processes:Protein fate:DNA metabolism:Regulatory functions:Other:Pathogenesis:Protein and peptide secretion and trafficking:DNA replication, recombination, and repair:Small molecule interactions:Protein interactions:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Folding Sorting and Degradation:Amino Acid Metabolism" 122 "ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:Fe2+/Zn2+ uptake regulation proteins:Fe2+/Zn2+ uptake regulation proteins:FOG: CheY-like receiver:FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Amidases related to nicotinamidase:Amidases related to nicotinamidase:Flagellin and related hook-associated proteins:Flagellin and related hook-associated proteins:Isochorismate hydrolase:Isochorismate hydrolase:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Carbon starvation protein, predicted membrane protein:Carbon starvation protein, predicted membrane protein:FOG: GGDEF domain:FOG: GGDEF domain:Predicted membrane protein:Predicted membrane protein:Heat shock protein:Heat shock protein:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:sequence-specific DNA binding transcription factor activity:catalytic activity:signal transducer activity:structural molecule activity:binding:regulation of transcription, DNA-dependent:chemotaxis:signal transduction:metabolic process:isochorismatase activity:cyclic nucleotide biosynthetic process:cellular response to starvation:transcription repressor activity:phosphorus-oxygen lyase activity:intracellular signal transduction:negative regulation of transcription, DNA-dependent:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:GGDEF:GGDEF:FlgM_jcvi:FlgM_jcvi:Signal transduction:Regulatory functions:Other:Small molecule interactions:Global:Cellular Processes:Environmental Information Processing:Metabolism:Cell Motility:Cellular processes and signaling:Signal Transduction:Metabolism:Poorly characterized:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:Small molecule interactions:Signal transduction:Other:Cellular processes and signaling:Metabolism:Poorly characterized" 123 "Energy production and conversion:Energy production and conversion:Molybdopterin biosynthesis enzyme:Molybdopterin biosynthesis enzyme:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Phosphatidylglycerophosphate synthase:Phosphatidylglycerophosphate synthase:2-methylthioadenine synthetase:2-methylthioadenine synthetase:FOG: CheY-like receiver:FOG: CheY-like receiver:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Flagellar motor component:Flagellar motor component:Flagellar GTP-binding protein:Flagellar GTP-binding protein:Periplasmic protein involved in polysaccharide export:Periplasmic protein involved in polysaccharide export:Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase:Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Leu/Phe-tRNA-protein transferase:Leu/Phe-tRNA-protein transferase:ABC-type transport system involved in resistance to organic solvents, auxiliary component:ABC-type transport system involved in resistance to organic solvents, auxiliary component:Uncharacterized iron-regulated protein:Uncharacterized iron-regulated protein:Outer membrane lipoprotein:Outer membrane lipoprotein:Ferredoxin-thioredoxin reductase, catalytic subunit:Ferredoxin-thioredoxin reductase, catalytic subunit:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:DNA binding:sequence-specific DNA binding transcription factor activity:motor activity:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity:uracil phosphoribosyltransferase activity:protein binding:ATP binding:electron transport:regulation of transcription, DNA-dependent:proteolysis:Mo-molybdopterin cofactor biosynthetic process:transport:chemotaxis:transcription factor binding:metabolic process:7S RNA binding:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity:protein transporter activity:phospholipid biosynthetic process:leucyltransferase activity:protein-glutamate methylesterase activity:nucleoside metabolic process:cobalamin biosynthetic process:pathogenesis:polysaccharide transmembrane transporter activity:polysaccharide transport:oxidoreductase activity:nucleoside-triphosphatase activity:heme binding:protein catabolic process:2-alkenal reductase [NAD(P)] activity:cobyrinic acid a,c-diamide synthase activity:regulation of protein secretion:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Fatty acid biosynthesis:Fatty acid biosynthesis:Pyrimidine metabolism:Pyrimidine metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Biosynthesis of unsaturated fatty acids:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Metabolic pathways:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00089:TIGR00089:pgsA:pgsA:aat:aat:Metabolism:Poorly characterized:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Protein fate:Fatty acid and phospholipid metabolism:Degradation of proteins, peptides, and glycopeptides:Biosynthesis:Global:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Cell Motility:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Signal Transduction:Cellular Processes:Signal Transduction:Global:Metabolism:Environmental Information Processing:Fatty acid and phospholipid metabolism:Biosynthesis:Protein fate:Degradation of proteins, peptides, and glycopeptides:Information storage and processing:Cellular processes and signaling" 124 "Chromatin structure and dynamics:Chromatin structure and dynamics:Energy production and conversion:Energy production and conversion:Molecular chaperone (small heat shock protein):Molecular chaperone (small heat shock protein):Chorismate synthase:Chorismate synthase:Deacetylases, including yeast histone deacetylase and acetoin utilization protein:Deacetylases, including yeast histone deacetylase and acetoin utilization protein:Fatty acid/phospholipid biosynthesis enzyme:Fatty acid/phospholipid biosynthesis enzyme:Aspartate ammonia-lyase:Aspartate ammonia-lyase:Hemolysins and related proteins containing CBS domains:Hemolysins and related proteins containing CBS domains:Predicted periplasmic solute-binding protein:Predicted periplasmic solute-binding protein:Cobalamin biosynthesis protein CbiG:Cobalamin biosynthesis protein CbiG:Predicted hydrolase (metallo-beta-lactamase superfamily):Predicted hydrolase (metallo-beta-lactamase superfamily):Arabinose efflux permease:Arabinose efflux permease:Ni,Fe-hydrogenase III large subunit:Ni,Fe-hydrogenase III large subunit:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:recombinase activity:catalytic activity:chorismate synthase activity:glycerol-3-phosphate O-acyltransferase activity:transporter activity:electron transport:DNA recombination:fatty acid biosynthetic process:transport:NADH dehydrogenase (ubiquinone) activity:metabolic process:aspartate ammonia-lyase activity:ferredoxin hydrogenase activity:aromatic amino acid family biosynthetic process:cobalamin biosynthetic process:nitrogen fixation:nickel ion binding:nitrogenase activity:hydrolase activity:NAD binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Glycerolipid metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Methane metabolism:Methane metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:aroC:aroC:plsX:plsX:Amino acid biosynthesis:Fatty acid and phospholipid metabolism:Biosynthesis:Amino acid biosynthesis:Aromatic amino acid family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:Lipid Metabolism:Energy Metabolism:Metabolism:Poorly characterized:Energy Metabolism:Fatty acid and phospholipid metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Metabolism:Global:Biosynthesis:Aromatic amino acid family:Global:Metabolism:Metabolism of Cofactors and Vitamins" 125 "Energy production and conversion:Energy production and conversion:Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:Membrane proteins related to metalloendopeptidases:Membrane proteins related to metalloendopeptidases:Fe-S oxidoreductase:Fe-S oxidoreductase:Flagellar biosynthesis/type III secretory pathway ATPase:Flagellar biosynthesis/type III secretory pathway ATPase:Flagellar biosynthesis/type III secretory pathway protein:Flagellar biosynthesis/type III secretory pathway protein:Flagellar motor switch protein:Flagellar motor switch protein:Flagellar basal body rod protein:Flagellar basal body rod protein:Flagellar hook-basal body protein:Flagellar hook-basal body protein:Flagellar basal-body P-ring protein:Flagellar basal-body P-ring protein:Flagellar biosynthesis/type III secretory pathway lipoprotein:Flagellar biosynthesis/type III secretory pathway lipoprotein:Flagellar basal body L-ring protein:Flagellar basal body L-ring protein:Flagellar basal body rod protein:Flagellar basal body rod protein:ciliary or flagellar motility:motor activity:catalytic activity:hydrogen-transporting two-sector ATPase activity:metalloendopeptidase activity:structural molecule activity:ATP binding:proteolysis:cation transport:chemotaxis:metabolic process:cation transmembrane transporter activity:flagellum assembly:protein transport:ATP synthesis coupled proton transport:cobalamin binding:flagellum organization:metal ion binding:hydrogen ion transporting ATP synthase activity, rotational mechanism:proton-transporting ATPase activity, rotational mechanism:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity:iron-sulfur cluster binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:fliE:fliE:fliF:fliF:fliG:fliG:fliI_yscN:fliI_yscN:FlgC:FlgC:flagell_FliJ:flagell_FliJ:flgG_G_neg:flgG_G_neg:flgF:flgF:flgK_ends:flgK_ends:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Cellular Processes:Cell Motility:Metabolism:Cellular processes and signaling:Energy metabolism:ATP-proton motive force interconversion:Cellular processes:Chemotaxis and motility:Cellular processes and signaling:Poorly characterized:Poorly characterized:Cellular processes:Energy metabolism:Chemotaxis and motility:ATP-proton motive force interconversion:Cellular Processes:Cell Motility" 126 "Energy production and conversion:Energy production and conversion:Polyferredoxin:Polyferredoxin:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:Predicted phosphatases:Predicted phosphatases:Topoisomerase IA:Topoisomerase IA:Branched-chain amino acid ABC-type transport system, permease components:Branched-chain amino acid ABC-type transport system, permease components:ABC-type phosphate transport system, permease component:ABC-type phosphate transport system, permease component:Mg2+ and Co2+ transporters:Mg2+ and Co2+ transporters:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:Acyl-CoA synthetase (NDP forming):Acyl-CoA synthetase (NDP forming):ABC-type phosphate transport system, ATPase component:ABC-type phosphate transport system, ATPase component:ABC-type spermidine/putrescine transport system, permease component I:ABC-type spermidine/putrescine transport system, permease component I:Predicted membrane protein:Predicted membrane protein:Metal-dependent amidase/aminoacylase/carboxypeptidase:Metal-dependent amidase/aminoacylase/carboxypeptidase:Cobyrinic acid a,c-diamide synthase:Cobyrinic acid a,c-diamide synthase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:ABC-type branched-chain amino acid transport system, permease component:ABC-type branched-chain amino acid transport system, permease component:ABC-type tungstate transport system, periplasmic component:ABC-type tungstate transport system, periplasmic component:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:DNA topoisomerase type I activity:transporter activity:inorganic phosphate transmembrane transporter activity:ATP binding:electron transport:DNA topological change:DNA unwinding involved in replication:DNA modification:regulation of transcription, DNA-dependent:proteolysis:transport:phosphate ion transport:transcription factor binding:metabolic process:metallopeptidase activity:phosphoglycolate phosphatase activity:electron carrier activity:cobalamin biosynthetic process:phosphate ion transmembrane-transporting ATPase activity:sulfate transmembrane-transporting ATPase activity:oxidoreductase activity:transferase activity:hydrolase activity:nucleoside-triphosphatase activity:metal ion transport:thiosulfate transmembrane-transporting ATPase activity:cobyrinic acid a,c-diamide synthase activity:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity:metal ion transmembrane transporter activity:protein dimerization activity:hippurate hydrolase activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:cobB:cobB:3a0107s01c2:3a0107s01c2:HAD-SF-IA-v1:HAD-SF-IA-v1:amidohydrolases:amidohydrolases:phosphate_pstC:phosphate_pstC:Anions:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Information storage and processing:Biosynthesis of cofactors, prosthetic groups, and carriers:Unknown function:Transport and binding proteins:Protein fate:Heme, porphyrin, and cobalamin:Enzymes of unknown specificity:Anions:Degradation of proteins, peptides, and glycopeptides:Global:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism:Environmental Information Processing:Membrane Transport:Poorly characterized:Global:Metabolism:Metabolism:Cellular processes and signaling:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins" 127 "Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Permeases of the drug/metabolite transporter (DMT) superfamily:Permeases of the drug/metabolite transporter (DMT) superfamily:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Micrococcal nuclease (thermonuclease) homologs:Micrococcal nuclease (thermonuclease) homologs:Uncharacterized conserved protein:Uncharacterized conserved protein:FOG: GGDEF domain:FOG: GGDEF domain:Arabinose efflux permease:Arabinose efflux permease:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:nucleic acid binding:DNA binding:transporter activity:DNA repair:regulation of transcription, DNA-dependent:transport:metabolic process:methyltransferase activity:zinc ion binding:transaminase activity:cyclic nucleotide biosynthetic process:thiamine biosynthetic process:tetracycline:hydrogen antiporter activity:tetracycline transport:phosphorus-oxygen lyase activity:pyridoxal phosphate binding:intracellular signal transduction:response to antibiotic:Replication, recombination and repair:Replication, recombination and repair:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:GGDEF:GGDEF:Energy Metabolism:Signal transduction:Other:Global:Metabolism:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Amino Acid Metabolism:Global:Metabolism:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Amino Acid Metabolism" 128 "Diaminopimelate decarboxylase:Diaminopimelate decarboxylase:Predicted sugar kinase:Predicted sugar kinase:Cell division GTPase:Cell division GTPase:Mismatch repair ATPase (MutS family):Mismatch repair ATPase (MutS family):Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis:Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis:Phosphoheptose isomerase:Phosphoheptose isomerase:Aspartate/tyrosine/aromatic aminotransferase:Aspartate/tyrosine/aromatic aminotransferase:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:Valyl-tRNA synthetase:Valyl-tRNA synthetase:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:UDP-N-acetylmuramoylalanine-D-glutamate ligase:UDP-N-acetylmuramoylalanine-D-glutamate ligase:Bacterial cell division membrane protein:Bacterial cell division membrane protein:UDP-N-acetylmuramate-alanine ligase:UDP-N-acetylmuramate-alanine ligase:Actin-like ATPase involved in cell division:Actin-like ATPase involved in cell division:Uncharacterized conserved protein:Uncharacterized conserved protein:Cell division septal protein:Cell division septal protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:cell morphogenesis:damaged DNA binding:catalytic activity:GTPase activity:NAD+ kinase activity:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity:valine-tRNA ligase activity:ATP binding:GTP binding:carbohydrate metabolic process:mismatch repair:valyl-tRNA aminoacylation:cell cycle:metabolic process:methyltransferase activity:regulation of cell shape:D-alanine-D-alanine ligase activity:UDP-N-acetylmuramate-L-alanine ligase activity:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity:diaminopimelate decarboxylase activity:phospho-N-acetylmuramoyl-pentapeptide-transferase activity:D-sedoheptulose 7-phosphate isomerase activity:biosynthetic process:lysine biosynthetic process via diaminopimelate:lipopolysaccharide core region biosynthetic process:peptidoglycan biosynthetic process:L,L-diaminopimelate aminotransferase activity:transferase activity, transferring nitrogenous groups:UDP-N-acetylgalactosamine biosynthetic process:pyridoxal phosphate binding:carbohydrate binding:lipid glycosylation:mismatched DNA binding:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity:protein polymerization:cell division:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Lysine biosynthesis:D-Glutamine and D-glutamate metabolism:D-Glutamine and D-glutamate metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Mismatch repair:Mismatch repair:General function prediction only:General function prediction only:Function unknown:Function unknown:TIGR00006:TIGR00006:ftsZ:ftsZ:TIGR00242:TIGR00242:valS:valS:mraY:mraY:lysA:lysA:mutS1:mutS1:murC:murC:murD:murD:murG:murG:ftsA:ftsA:ftsW:ftsW:DapC_direct:DapC_direct:Amino Acid Metabolism:Global:Cellular processes:tRNA aminoacylation:Cell division:General:Aspartate family:Biosynthesis and degradation of murein sacculus and peptidoglycan:DNA metabolism:Protein synthesis:Cellular processes:Unknown function:Amino acid biosynthesis:Cell envelope:Genetic Information Processing:Metabolism:Metabolism:Replication and Repair:Translation:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:DNA replication, recombination, and repair:Cell division:Unknown function:General:Amino acid biosynthesis:Aspartate family:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Other Amino Acids" 129 "Predicted phage phi-C31 gp36 major capsid-like protein:Predicted phage phi-C31 gp36 major capsid-like protein:Phage-related protein:Phage-related protein:DNA binding:deoxyribonuclease activity:DNA methylation:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Metabolic pathways:Metabolic pathways:General function prediction only:General function prediction only:Function unknown:Function unknown:dcm:dcm:portal_HK97:portal_HK97:major_cap_HK97:major_cap_HK97:phage_chp_gp8:phage_chp_gp8:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Mobile and extrachromosomal element functions:Prophage functions:Poorly characterized:Metabolism:Metabolism:Global:DNA replication, recombination, and repair:Prophage functions:DNA metabolism:Mobile and extrachromosomal element functions:Amino Acid Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism" 130 "Energy production and conversion:Energy production and conversion:Glutamate dehydrogenase/leucine dehydrogenase:Glutamate dehydrogenase/leucine dehydrogenase:Uncharacterized conserved protein:Uncharacterized conserved protein:Nitrogenase molybdenum-iron protein, alpha and beta chains:Nitrogenase molybdenum-iron protein, alpha and beta chains:Membrane-bound lytic murein transglycosylase:Membrane-bound lytic murein transglycosylase:ABC-type uncharacterized transport system, permease component:ABC-type uncharacterized transport system, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:hydrolase activity, hydrolyzing O-glycosyl compounds:transporter activity:protein binding:electron transport:protein complex assembly:cellular amino acid metabolic process:transport:peptidoglycan turnover:nitrogen fixation:nitrogenase activity:oxidoreductase activity:iron-iron nitrogenase activity:molybdenum-iron nitrogenase activity:vanadium-iron nitrogenase activity:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Nitrogen metabolism:Nitrogen metabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:nifE:nifE:tape_meas_nterm:tape_meas_nterm:Central intermediary metabolism:Central intermediary metabolism:Metabolism:Energy Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Nitrogen fixation:Nitrogen fixation:Cellular processes and signaling:Metabolism:Poorly characterized" 131 "Glycosyltransferase:Glycosyltransferase:Adenylylsulfate kinase and related kinases:Adenylylsulfate kinase and related kinases:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Flagellar biosynthesis pathway, component FlhB:Flagellar biosynthesis pathway, component FlhB:Flagellar motor switch/type III secretory pathway protein:Flagellar motor switch/type III secretory pathway protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Serine phosphatase RsbU, regulator of sigma subunit:Serine phosphatase RsbU, regulator of sigma subunit:ABC-type uncharacterized transport system, periplasmic component:ABC-type uncharacterized transport system, periplasmic component:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Uncharacterized protein predicted to be involved in DNA repair:Uncharacterized protein predicted to be involved in DNA repair:Type III secretory pathway, component EscV:Type III secretory pathway, component EscV:Type III secretory pathway, component EscR:Type III secretory pathway, component EscR:Type III secretory pathway, component EscT:Type III secretory pathway, component EscT:Type III secretory pathway, component EscS:Type III secretory pathway, component EscS:sulfate assimilation:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:adenylylsulfate kinase activity:phosphoprotein phosphatase activity:triglyceride lipase activity:signal transducer activity:binding:ATP binding:regulation of transcription, DNA-dependent:protein targeting:sulfur compound metabolic process:transport:response to stress:signal transduction:transcription factor binding:protein transporter activity:biosynthetic process:protein secretion:pathogenesis:protein transport:type III protein (virulence-related) secretor activity:nucleoside-triphosphatase activity:protein secretion by the type III secretion system:antisigma factor binding:regulation of protein secretion:negative regulation of protein secretion:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Selenocompound metabolism:Selenocompound metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:ant_ant_sig:ant_ant_sig:apsK:apsK:yscR:yscR:hrcV:hrcV:fliR_like_III:fliR_like_III:fliQ_rel_III:fliQ_rel_III:FlhB_rel_III:FlhB_rel_III:cas_CT1132:cas_CT1132:cas_Csd1:cas_Csd1:type_III_yscD:type_III_yscD:type_III_tyeA:type_III_tyeA:SpaO_YscQ:SpaO_YscQ:LcrH_SycD:LcrH_SycD:PEP_exosort:PEP_exosort:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Other:Cell envelope:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Metabolism of Other Amino Acids:Nucleotide Metabolism:Energy Metabolism:Cell envelope:Mobile and extrachromosomal element functions:Cellular processes:Regulatory functions:Central intermediary metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Surface structures:Nucleotide Metabolism:Other:Metabolism of Other Amino Acids:Pathogenesis:Environmental Information Processing:Membrane Transport:Protein interactions:Global:Metabolism:Sulfur metabolism:Global:Central intermediary metabolism:Sulfur metabolism:Regulatory functions:Protein interactions:Cellular processes:Pathogenesis:Mobile and extrachromosomal element functions" 132 "Energy production and conversion:Energy production and conversion:Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:FOG: CheY-like receiver:FOG: CheY-like receiver:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Predicted hydrolase (HAD superfamily):Predicted hydrolase (HAD superfamily):Ferredoxin:Ferredoxin:Transcriptional regulator:Transcriptional regulator:Methylase of chemotaxis methyl-accepting proteins:Methylase of chemotaxis methyl-accepting proteins:Ferritin-like protein:Ferritin-like protein:Cytochrome c553:Cytochrome c553:Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein:Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:peptidyl-prolyl cis-trans isomerase activity:catalytic activity:ferroxidase activity:multicopper ferroxidase iron transport mediator activity:hydrolase activity, hydrolyzing O-glycosyl compounds:cyclophilin:signal transducer activity:transporter activity:iron ion binding:carbohydrate metabolic process:electron transport:regulation of transcription, DNA-dependent:Mo-molybdopterin cofactor biosynthetic process:sulfur compound metabolic process:transport:iron ion transport:cellular iron ion homeostasis:chemotaxis:response to stress:signal transduction:metabolic process:ferric iron binding:glutamate racemase activity:protein-glutamate O-methyltransferase activity:electron carrier activity:specific transcriptional repressor activity:heme binding:metal ion transport:FK506-sensitive peptidyl-prolyl cis-trans isomerase:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:negative regulation of transcription, DNA-dependent:metal ion binding:iron-sulfur cluster binding:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:Metabolism of Cofactors and Vitamins:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Cellular Processes:Environmental Information Processing:Metabolism:Cell Motility:Signal Transduction:Metabolism of Cofactors and Vitamins:Signal Transduction:Cellular Processes:Environmental Information Processing:Cell Motility:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 133 "Energy production and conversion:Energy production and conversion:Fe-S oxidoreductase:Fe-S oxidoreductase:Glutamate 5-kinase:Glutamate 5-kinase:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Predicted GTPase:Predicted GTPase:FOG: CheY-like receiver:FOG: CheY-like receiver:Cation/multidrug efflux pump:Cation/multidrug efflux pump:Membrane-fusion protein:Membrane-fusion protein:Transcriptional regulator:Transcriptional regulator:Restriction endonuclease:Restriction endonuclease:Outer membrane protein:Outer membrane protein:DnaK suppressor protein:DnaK suppressor protein:Predicted transcriptional regulator:Predicted transcriptional regulator:Tryptophanase:Tryptophanase:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:sequence-specific DNA binding transcription factor activity:RNA binding:glutamate 5-kinase activity:endonuclease activity:transporter activity:iron ion binding:GTP binding:electron transport:regulation of transcription, DNA-dependent:proline biosynthetic process:transport:zinc ion binding:lipid binding:protein transporter activity:tryptophanase activity:electron carrier activity:aromatic amino acid family metabolic process:protein secretion:specific transcriptional repressor activity:heme binding:pyridoxal phosphate binding:negative regulation of transcription, DNA-dependent:iron-sulfur cluster binding:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Arginine and proline metabolism:Arginine and proline metabolism:Tryptophan metabolism:Tryptophan metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:rrf2_super:rrf2_super:2A0602:2A0602:proB:proB:RND_mfp:RND_mfp:outer_NodT:outer_NodT:Obg_CgtA:Obg_CgtA:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:General:Metabolism:Metabolism:Global:Other:Unknown substrate:Porins:General:Glutamate family:Protein synthesis:Transport and binding proteins:Unknown function:Amino acid biosynthesis:Energy Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Amino Acid Metabolism:Global:Metabolism:Protein synthesis:Other:Transport and binding proteins:Unknown substrate:Porins:Unknown function:Amino Acid Metabolism:Amino acid biosynthesis:Glutamate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 134 "Energy production and conversion:Energy production and conversion:Predicted rRNA methylase:Predicted rRNA methylase:Predicted Fe-S oxidoreductase:Predicted Fe-S oxidoreductase:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:DNA binding:RNA binding:catalytic activity:electron transport:regulation of transcription, DNA-dependent:metabolic process:electron carrier activity:hemolysis by symbiont of host erythrocytes:thiamine pyrophosphate binding:indolepyruvate ferredoxin oxidoreductase activity:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:General function prediction only:General function prediction only:tly:tly:TIGR01212:TIGR01212:excise:excise:Metabolism:Poorly characterized:General:Enzymes of unknown specificity:General:Information storage and processing:Metabolism:Poorly characterized:Unknown function:Enzymes of unknown specificity:Unknown function:Information storage and processing" 135 "Energy production and conversion:Energy production and conversion:Glutamine synthetase:Glutamine synthetase:Predicted divalent heavy-metal cations transporter:Predicted divalent heavy-metal cations transporter:Glycosyltransferase:Glycosyltransferase:K+ transport systems, NAD-binding component:K+ transport systems, NAD-binding component:dsRNA-specific ribonuclease:dsRNA-specific ribonuclease:Phosphopantetheine adenylyltransferase:Phosphopantetheine adenylyltransferase:Permeases of the drug/metabolite transporter (DMT) superfamily:Permeases of the drug/metabolite transporter (DMT) superfamily:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Fe-S oxidoreductase:Fe-S oxidoreductase:Oxygen-sensitive ribonucleoside-triphosphate reductase:Oxygen-sensitive ribonucleoside-triphosphate reductase:Flagellar motor protein:Flagellar motor protein:Long-chain fatty acid transport protein:Long-chain fatty acid transport protein:Membrane-bound lytic murein transglycosylase B:Membrane-bound lytic murein transglycosylase B:Paraquat-inducible protein B:Paraquat-inducible protein B:Uncharacterized protein conserved in archaea:Uncharacterized protein conserved in archaea:ABC-type uncharacterized transport system, periplasmic component:ABC-type uncharacterized transport system, periplasmic component:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):double-stranded RNA binding:catalytic activity:glutamate-ammonia ligase activity:ribonuclease III activity:pantetheine-phosphate adenylyltransferase activity:receptor activity:transporter activity:regulation of transcription, DNA-dependent:RNA processing:glutamine biosynthetic process:transport:potassium ion transport:metabolic process:cation transmembrane transporter activity:ribonucleoside-triphosphate reductase activity:biosynthetic process:nitrogen fixation:coenzyme A biosynthetic process:rRNA catabolic process:metal ion transport:cobalamin binding:[formate-C-acetyltransferase]-activating enzyme activity:sequence-specific DNA binding:metal ion binding:metal ion transmembrane transporter activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:cyt_tran_rel:cyt_tran_rel:sensory_box:sensory_box:RNaseIII:RNaseIII:NrdD:NrdD:NrdG2:NrdG2:Cellular Processes:2'-Deoxyribonucleotide metabolism:Small molecule interactions:RNA processing:Protein modification and repair:Purines, pyrimidines, nucleosides, and nucleotides:Regulatory functions:Transcription:Protein fate:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:Regulatory functions:Small molecule interactions:Transcription:RNA processing:Protein fate:Protein modification and repair:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Signal Transduction:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Global" 136 "Glycosyltransferase:Glycosyltransferase:Adenylylsulfate kinase and related kinases:Adenylylsulfate kinase and related kinases:Flagellar biosynthesis/type III secretory pathway ATPase:Flagellar biosynthesis/type III secretory pathway ATPase:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Flagellar biosynthesis pathway, component FlhB:Flagellar biosynthesis pathway, component FlhB:Type II secretory pathway, component PulD:Type II secretory pathway, component PulD:Flagellar motor switch/type III secretory pathway protein:Flagellar motor switch/type III secretory pathway protein:Anti-sigma regulatory factor (Ser/Thr protein kinase):Anti-sigma regulatory factor (Ser/Thr protein kinase):Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Serine phosphatase RsbU, regulator of sigma subunit:Serine phosphatase RsbU, regulator of sigma subunit:ABC-type uncharacterized transport system, periplasmic component:ABC-type uncharacterized transport system, periplasmic component:Type III secretory pathway, lipoprotein EscJ:Type III secretory pathway, lipoprotein EscJ:Type III secretory pathway, component EscV:Type III secretory pathway, component EscV:Type III secretory pathway, component EscR:Type III secretory pathway, component EscR:sulfate assimilation:two-component signal transduction system (phosphorelay):nucleotide binding:sequence-specific DNA binding transcription factor activity:catalytic activity:hydrogen-transporting two-sector ATPase activity:adenylylsulfate kinase activity:phosphoprotein phosphatase activity:triglyceride lipase activity:signal transducer activity:binding:ATP binding:regulation of transcription, DNA-dependent:sulfur compound metabolic process:transport:response to stress:signal transduction:transcription factor binding:protein transporter activity:biosynthetic process:protein secretion:pathogenesis:protein transport:type III protein (virulence-related) secretor activity:ATP synthesis coupled proton transport:nucleoside-triphosphatase activity:protein secretion by the type III secretion system:antisigma factor binding:hydrogen ion transporting ATP synthase activity, rotational mechanism:proton-transporting ATPase activity, rotational mechanism:regulation of protein secretion:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Selenocompound metabolism:Selenocompound metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:ant_ant_sig:ant_ant_sig:apsK:apsK:fliI_yscN:fliI_yscN:yscR:yscR:hrcV:hrcV:FlhB_rel_III:FlhB_rel_III:cas_Csd1:cas_Csd1:type_III_yscD:type_III_yscD:type_III_yscC:type_III_yscC:III_secr_YscJ:III_secr_YscJ:SpaO_YscQ:SpaO_YscQ:LcrH_SycD:LcrH_SycD:PEP_exosort:PEP_exosort:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Regulatory functions:Protein interactions:Cellular processes:Pathogenesis:Mobile and extrachromosomal element functions:Other:Cell envelope:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Metabolism of Other Amino Acids:Nucleotide Metabolism:Energy Metabolism:Cell envelope:Mobile and extrachromosomal element functions:Cellular processes:Regulatory functions:Energy metabolism:Central intermediary metabolism:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Other:Nucleotide Metabolism:Pathogenesis:Metabolism of Other Amino Acids:Protein interactions:Environmental Information Processing:Membrane Transport:ATP-proton motive force interconversion:Global:Metabolism:Sulfur metabolism:Global:Central intermediary metabolism:Sulfur metabolism:Energy metabolism:ATP-proton motive force interconversion" 137 "Energy production and conversion:Energy production and conversion:Ornithine carbamoyltransferase:Ornithine carbamoyltransferase:5-enolpyruvylshikimate-3-phosphate synthase:5-enolpyruvylshikimate-3-phosphate synthase:ABC-type phosphate transport system, periplasmic component:ABC-type phosphate transport system, periplasmic component:Glycerol-3-phosphate dehydrogenase:Glycerol-3-phosphate dehydrogenase:Nucleoside-diphosphate-sugar epimerases:Nucleoside-diphosphate-sugar epimerases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:Nitroreductase:Nitroreductase:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:Zn-ribbon protein, possibly nucleic acid-binding:Zn-ribbon protein, possibly nucleic acid-binding:ABC-type sugar transport system, periplasmic component:ABC-type sugar transport system, periplasmic component:Outer membrane protein:Outer membrane protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:RecB family exonuclease:RecB family exonuclease:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:catalytic activity:glutamate synthase (NADPH) activity:glycerol-3-phosphate dehydrogenase [NAD+] activity:ornithine carbamoyltransferase activity:signal transducer activity:transporter activity:iron ion binding:protein binding:carbohydrate metabolic process:electron transport:cellular amino acid metabolic process:glutamate biosynthetic process:transport:chemotaxis:signal transduction:metabolic process:dTDP-4-dehydrorhamnose reductase activity:ferredoxin hydrogenase activity:electron carrier activity:protein disulfide oxidoreductase activity:glutamate synthase (NADH) activity:oxidoreductase activity:amino acid binding:transferase activity:transferase activity, transferring alkyl or aryl (other than methyl) groups:'de novo' GDP-L-fucose biosynthetic process:extracellular polysaccharide biosynthetic process:cell redox homeostasis:glycerol-3-phosphate catabolic process:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity:GDP-L-fucose synthase activity:coenzyme binding:NAD binding:iron-sulfur cluster binding:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Fructose and mannose metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Methane metabolism:Methane metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:HDIG:HDIG:orni_carb_tr:orni_carb_tr:gltA:gltA:TAT_signal_seq:TAT_signal_seq:ptsS_2:ptsS_2:Carbohydrate Metabolism:Metabolism:Protein and peptide secretion and trafficking:Cellular Processes:Global:Protein and peptide secretion and trafficking:Anions:Glutamate family:Protein fate:Transport and binding proteins:Amino acid biosynthesis:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Amino Acid Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Protein fate:Environmental Information Processing:Transport and binding proteins:Anions:Amino acid biosynthesis:Glutamate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Lipid Metabolism:Energy Metabolism" 138 "Energy production and conversion:Energy production and conversion:Predicted divalent heavy-metal cations transporter:Predicted divalent heavy-metal cations transporter:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Membrane transporters of cations and cationic drugs:Membrane transporters of cations and cationic drugs:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Predicted membrane protein:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Mu-like prophage tail sheath protein gpL:Mu-like prophage tail sheath protein gpL:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:ATP-dependent peptidase activity:ATP binding:electron transport:regulation of transcription, DNA-dependent:proteolysis:transcription factor binding:endopeptidase La activity:Type II site-specific deoxyribonuclease activity:electron carrier activity:DNA restriction-modification system:nucleoside-triphosphatase activity:metal ion transport:metal ion transmembrane transporter activity:iron-sulfur cluster binding:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TAT_signal_seq:TAT_signal_seq:Poorly characterized:Protein fate:Protein and peptide secretion and trafficking:Metabolism:Cellular processes and signaling:Metabolism:Cellular processes and signaling:Poorly characterized:Protein and peptide secretion and trafficking:Protein fate" 139 "Energy production and conversion:Energy production and conversion:Tyrosyl-tRNA synthetase:Tyrosyl-tRNA synthetase:Fe-S oxidoreductase:Fe-S oxidoreductase:NAD-dependent DNA ligase (contains BRCT domain type II):NAD-dependent DNA ligase (contains BRCT domain type II):Ni,Fe-hydrogenase I large subunit:Ni,Fe-hydrogenase I large subunit:NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases:NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases:Thiamine biosynthesis protein ThiC:Thiamine biosynthesis protein ThiC:Methionine synthase II (cobalamin-independent):Methionine synthase II (cobalamin-independent):Spermidine/putrescine-binding periplasmic protein:Spermidine/putrescine-binding periplasmic protein:Lactate dehydrogenase and related dehydrogenases:Lactate dehydrogenase and related dehydrogenases:Na+/H+ antiporter NhaD and related arsenite permeases:Na+/H+ antiporter NhaD and related arsenite permeases:Uncharacterized conserved protein containing a ferredoxin-like domain:Uncharacterized conserved protein containing a ferredoxin-like domain:ABC-type spermidine/putrescine transport system, permease component II:ABC-type spermidine/putrescine transport system, permease component II:Predicted exonuclease of the beta-lactamase fold involved in RNA processing:Predicted exonuclease of the beta-lactamase fold involved in RNA processing:Membrane-associated lipoprotein involved in thiamine biosynthesis:Membrane-associated lipoprotein involved in thiamine biosynthesis:Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins:Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins:L-lactate permease:L-lactate permease:Ni,Fe-hydrogenase I small subunit:Ni,Fe-hydrogenase I small subunit:Predicted NADH:ubiquinone oxidoreductase, subunit RnfB:Predicted NADH:ubiquinone oxidoreductase, subunit RnfB:Membrane protein involved in colicin uptake:Membrane protein involved in colicin uptake:Predicted NADH:ubiquinone oxidoreductase, subunit RnfA:Predicted NADH:ubiquinone oxidoreductase, subunit RnfA:Predicted NADH:ubiquinone oxidoreductase, subunit RnfD:Predicted NADH:ubiquinone oxidoreductase, subunit RnfD:Predicted NADH:ubiquinone oxidoreductase, subunit RnfG:Predicted NADH:ubiquinone oxidoreductase, subunit RnfG:Predicted NADH:ubiquinone oxidoreductase, subunit RnfE:Predicted NADH:ubiquinone oxidoreductase, subunit RnfE:Ornithine/acetylornithine aminotransferase:Ornithine/acetylornithine aminotransferase:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:nucleic acid binding:DNA binding:RNA binding:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity:DNA ligase (NAD+) activity:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity:aspartate kinase activity:ornithine carbamoyltransferase activity:phosphoglycerate dehydrogenase activity:tyrosine-tRNA ligase activity:transporter activity:iron ion transmembrane transporter activity:iron ion binding:ATP binding:glycerol metabolic process:gluconeogenesis:electron transport:mitochondrial electron transport, NADH to ubiquinone:DNA replication:DNA repair:tyrosyl-tRNA aminoacylation:arginine metabolic process:transport:iron ion transport:NADH dehydrogenase (ubiquinone) activity:metabolic process:zinc ion binding:protein transporter activity:ferredoxin hydrogenase activity:electron carrier activity:biosynthetic process:methionine biosynthetic process:thiamine biosynthetic process:folic acid-containing compound biosynthetic process:FMN binding:protein transport:lactate transmembrane transporter activity:iron-chelate-transporting ATPase activity:lactate transport:nickel ion binding:oxidoreductase activity, acting on NADH or NADPH:hydrolase activity:heme binding:pyridoxal phosphate binding:5-formyltetrahydrofolate cyclo-ligase activity:hydrogenase (acceptor) activity:fructose 1,6-bisphosphate 1-phosphatase activity:sequence-specific DNA binding:succinylornithine transaminase activity:NAD binding:iron-sulfur cluster binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Fructose and mannose metabolism:Fructose and mannose metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Methane metabolism:Methane metabolism:Thiamine metabolism:Thiamine metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:DNA replication:DNA replication:Base excision repair:Base excision repair:Nucleotide excision repair:Nucleotide excision repair:Mismatch repair:Mismatch repair:General function prediction only:General function prediction only:thiC:thiC:tyrS:tyrS:glpX:glpX:hydA:hydA:dnlj:dnlj:argD:argD:lctP:lctP:tonB_Cterm:tonB_Cterm:met_syn_B12ind:met_syn_B12ind:rnfA:rnfA:rnfD:rnfD:rnfE:rnfE:nuoB_fam:nuoB_fam:Global:Pentose phosphate pathway:DNA replication, recombination, and repair:tRNA aminoacylation:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Aspartate family:Thiamine:Energy metabolism:DNA metabolism:Protein synthesis:Transport and binding proteins:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Replication and Repair:Translation:Metabolism of Cofactors and Vitamins:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Pentose phosphate pathway:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Electron transport" 140 "" 141 "Dihydroorotase and related cyclic amidohydrolases:Dihydroorotase and related cyclic amidohydrolases:Superfamily I DNA and RNA helicases:Superfamily I DNA and RNA helicases:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Cytosine deaminase and related metal-dependent hydrolases:Cytosine deaminase and related metal-dependent hydrolases:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:ATPase involved in DNA repair:ATPase involved in DNA repair:Aspartate carbamoyltransferase, catalytic chain:Aspartate carbamoyltransferase, catalytic chain:Signal transduction histidine kinase:Signal transduction histidine kinase:FOG: CheY-like receiver:FOG: CheY-like receiver:Predicted nucleoside-diphosphate sugar epimerase:Predicted nucleoside-diphosphate sugar epimerase:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Outer membrane protein:Outer membrane protein:Precorrin isomerase:Precorrin isomerase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized protein related to Endonuclease III:Uncharacterized protein related to Endonuclease III:Predicted permeases:Predicted permeases:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Kef-type K+ transport system, predicted NAD-binding component:Kef-type K+ transport system, predicted NAD-binding component:Membrane carboxypeptidase/penicillin-binding protein:Membrane carboxypeptidase/penicillin-binding protein:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:actin binding:catalytic activity:DNA-(apurinic or apyrimidinic site) lyase activity:ATP-dependent DNA helicase activity:allantoinase activity:aspartate carbamoyltransferase activity:dihydroorotase activity:serine-type endopeptidase activity:transporter activity:protein binding:ATP binding:'de novo' pyrimidine base biosynthetic process:DNA metabolic process:DNA repair:base-excision repair:regulation of transcription, DNA-dependent:proteolysis:cellular amino acid metabolic process:transport:potassium ion transport:regulation of pH:signal transduction:transcription factor binding:peptidase activity:penicillin binding:cobalamin biosynthetic process:peptidoglycan biosynthetic process:solute:hydrogen antiporter activity:amino acid binding:transferase activity, transferring pentosyl groups:hydrolase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:precorrin-8X methylmutase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:pyridoxal phosphate binding:cobyrinic acid a,c-diamide synthase activity:sequence-specific DNA binding:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity:cellular metabolic process:response to antibiotic:coenzyme binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Bacterial secretion system:Bacterial secretion system:Nucleotide excision repair:Nucleotide excision repair:Mismatch repair:Mismatch repair:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:HDIG:HDIG:asp_carb_tr:asp_carb_tr:rarD:rarD:pyrC_multi:pyrC_multi:yfcH:yfcH:PBP_1a_fam:PBP_1a_fam:SAM_YgiQ:SAM_YgiQ:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Genetic Information Processing:Pyrimidine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Transport and binding proteins:Unknown substrate:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Amino Acid Metabolism:Nucleotide Metabolism:Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Metabolism:Membrane Transport:Replication and Repair:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Unknown substrate:Environmental Information Processing:Global:Cell envelope:Unknown function:Hypothetical proteins:Transport and binding proteins:Purines, pyrimidines, nucleosides, and nucleotides:Biosynthesis and degradation of murein sacculus and peptidoglycan:Enzymes of unknown specificity:Conserved:Global:Metabolism:Membrane Transport:Environmental Information Processing:Replication and Repair" 142 "" 143 "Energy production and conversion:Energy production and conversion:Predicted GTPase:Predicted GTPase:Ribosomal protein L31:Ribosomal protein L31:Ribosomal protein S1:Ribosomal protein S1:Fe-S oxidoreductases:Fe-S oxidoreductases:3-dehydroquinate dehydratase II:3-dehydroquinate dehydratase II:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:FOG: CheY-like receiver:FOG: CheY-like receiver:Pyruvate carboxylase:Pyruvate carboxylase:D-alanyl-D-alanine carboxypeptidase:D-alanyl-D-alanine carboxypeptidase:Protein-L-isoaspartate carboxylmethyltransferase:Protein-L-isoaspartate carboxylmethyltransferase:Predicted transcriptional regulator:Predicted transcriptional regulator:Predicted transcriptional regulator:Predicted transcriptional regulator:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:structural constituent of ribosome:catalytic activity:3-dehydroquinate dehydratase activity:GTPase activity:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity:pyruvate carboxylase activity:transporter activity:ATP binding:GTP binding:gluconeogenesis:regulation of transcription, DNA-dependent:translation:protein modification process:proteolysis:transport:metabolic process:zinc ion binding:serine-type D-Ala-D-Ala carboxypeptidase activity:aromatic amino acid family biosynthetic process:biotin binding:ferrous iron transmembrane transporter activity:ferrous iron transport:proton transport:transcription repressor activity:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances:protein repair:negative regulation of transcription, DNA-dependent:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Ribosome:Ribosome:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:pimt:pimt:L31:L31:rpsA:rpsA:HEQRo_perm_3TM:HEQRo_perm_3TM:GTPase_YsxC:GTPase_YsxC:Cellular processes and signaling:Global:Metabolism:Information storage and processing:Transport and binding proteins:Protein fate:Protein synthesis:Other:Ribosomal proteins: synthesis and modification:Protein fate:Protein modification and repair:Transport and binding proteins:Amino acids, peptides and amines:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Protein synthesis:Amino acids, peptides and amines:Protein modification and repair:Ribosomal proteins: synthesis and modification:Other:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Translation:Glycan Biosynthesis and Metabolism:Carbohydrate Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Amino Acid Metabolism:Metabolism:Glycan Biosynthesis and Metabolism:Poorly characterized:Genetic Information Processing:Translation:Metabolism:Environmental Information Processing:Membrane Transport" 144 "Energy production and conversion:Energy production and conversion:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Glycosyltransferase:Glycosyltransferase:rRNA methylase:rRNA methylase:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Predicted glycosyltransferases:Predicted glycosyltransferases:Purine-cytosine permease and related proteins:Purine-cytosine permease and related proteins:FOG: EAL domain:FOG: EAL domain:Nitrate/nitrite transporter:Nitrate/nitrite transporter:CO dehydrogenase maturation factor:CO dehydrogenase maturation factor:ABC-type transport system, involved in lipoprotein release, permease component:ABC-type transport system, involved in lipoprotein release, permease component:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component sensor activity:RNA binding:protein histidine kinase activity:signal transducer activity:transporter activity:iron ion binding:ATP binding:sugar binding:electron transport:RNA processing:transport:anion transport:signal transduction:RNA methyltransferase activity:formate dehydrogenase (NAD+) activity:electron carrier activity:biosynthetic process:cyclic nucleotide biosynthetic process:cobalamin biosynthetic process:RNA modification:phosphorus-oxygen lyase activity:ATPase activity:peptidyl-histidine phosphorylation:heme binding:intracellular signal transduction:cobyrinic acid a,c-diamide synthase activity:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:GGDEF:GGDEF:Defense mechanisms:Defense mechanisms:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Energy Metabolism:Carbohydrate Metabolism:Signal transduction:Other:Metabolism:Global:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Energy Metabolism:Carbohydrate Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Metabolism:Information storage and processing:Global:Membrane Transport:Signal transduction:Other:Information storage and processing" 145 "Energy production and conversion:Energy production and conversion:ABC-type Co2+ transport system, permease component:ABC-type Co2+ transport system, permease component:Guanosine polyphosphate pyrophosphohydrolases/synthetases:Guanosine polyphosphate pyrophosphohydrolases/synthetases:Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted hydrolase of the metallo-beta-lactamase superfamily:Predicted hydrolase of the metallo-beta-lactamase superfamily:ABC-type cobalt transport system, permease component CbiQ and related transporters:ABC-type cobalt transport system, permease component CbiQ and related transporters:Signal transduction histidine kinase:Signal transduction histidine kinase:NADH:ubiquinone oxidoreductase subunit 1 (chain H):NADH:ubiquinone oxidoreductase subunit 1 (chain H):NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I):Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I):Phosphatidylserine synthase:Phosphatidylserine synthase:FOG: LysM repeat:FOG: LysM repeat:L-lactate permease:L-lactate permease:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Surface lipoprotein:Surface lipoprotein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:ABC-type phosphate/phosphonate transport system, periplasmic component:ABC-type phosphate/phosphonate transport system, periplasmic component:Ni,Fe-hydrogenase III large subunit:Ni,Fe-hydrogenase III large subunit:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase:Signal transduction histidine kinase:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):catalytic activity:CDP-diacylglycerol-serine O-phosphatidyltransferase activity:nicotinate-nucleotide diphosphorylase (carboxylating) activity:protein histidine kinase activity:electron transporter activity:ATP binding:electron transport:regulation of transcription, DNA-dependent:protein modification process:phosphatidylcholine biosynthetic process:cobalt ion transport:signal transduction:NADH dehydrogenase (ubiquinone) activity:phospholipid biosynthetic process:GTP diphosphokinase activity:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity:electron carrier activity:cobalamin biosynthetic process:NAD biosynthetic process:protein transport:cobalt ion transmembrane transporter activity:lactate transmembrane transporter activity:phosphonate transmembrane transporter activity:phosphonate transport:lactate transport:stringent response:guanosine tetraphosphate metabolic process:nickel ion binding:amino acid binding:hydrolase activity:cell wall macromolecule catabolic process:peptidyl-histidine phosphorylation:pyridoxal phosphate binding:ATP synthesis coupled electron transport:protein dimerization activity:NAD binding:iron-sulfur cluster binding:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:TIGR00282:TIGR00282:pssA:pssA:spoT_relA:spoT_relA:lctP:lctP:3A0109s03R:3A0109s03R:CbiQ_TIGR:CbiQ_TIGR:Anions:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Cellular processes:Adaptations to atypical conditions:Unknown function:Enzymes of unknown specificity:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cellular processes:Transport and binding proteins:Regulatory functions:Fatty acid and phospholipid metabolism:Enzymes of unknown specificity:Adaptations to atypical conditions:Cations and iron carrying compounds:Carbohydrates, organic alcohols, and acids:Anions:Small molecule interactions:Biosynthesis:Global:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Amino Acid Metabolism:Metabolism:Lipid Metabolism:Nucleotide Metabolism:Poorly characterized:Metabolism:Lipid Metabolism:Cellular processes and signaling:Nucleotide Metabolism:Information storage and processing:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Unknown function:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:Transport and binding proteins" 146 "Energy production and conversion:Energy production and conversion:Predicted sugar kinase:Predicted sugar kinase:Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase:Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase:Phosphoribosylaminoimidazole (AIR) synthetase:Phosphoribosylaminoimidazole (AIR) synthetase:Aspartate/tyrosine/aromatic aminotransferase:Aspartate/tyrosine/aromatic aminotransferase:Predicted permeases:Predicted permeases:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Aconitase A:Aconitase A:Nicotinic acid mononucleotide adenylyltransferase:Nicotinic acid mononucleotide adenylyltransferase:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:FOG: LysM repeat:FOG: LysM repeat:Coenzyme F390 synthetase:Coenzyme F390 synthetase:DnaK suppressor protein:DnaK suppressor protein:Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein:Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:histidine biosynthetic process:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity:aconitate hydratase activity:L-aspartate:2-oxoglutarate aminotransferase activity:dihydrolipoyl dehydrogenase activity:nicotinate-nucleotide adenylyltransferase activity:phosphoribosylformylglycinamidine cyclo-ligase activity:thymidylate synthase activity:ionotropic glutamate receptor activity:extracellular-glutamate-gated ion channel activity:iron ion binding:electron transport:'de novo' IMP biosynthetic process:regulation of transcription, DNA-dependent:transport:metabolic process:zinc ion binding:lipid binding:cellular amino acid biosynthetic process:electron carrier activity:biosynthetic process:NAD biosynthetic process:transferase activity, transferring nitrogenous groups:cell wall macromolecule catabolic process:heme binding:pyridoxal phosphate binding:sequence-specific DNA binding:cell redox homeostasis:phenylacetate-CoA ligase activity:flavin adenine dinucleotide binding:thymidylate synthase biosynthetic process:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Purine metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine degradation:Arginine and proline metabolism:Arginine and proline metabolism:Histidine metabolism:Histidine metabolism:Tyrosine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Novobiocin biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00007:TIGR00007:yjeF_cterm:yjeF_cterm:TIGR00482:TIGR00482:purM:purM:acon_putative:acon_putative:dksA:dksA:Membrane Transport:Energy metabolism:TCA cycle:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:Unknown function:General:Amino acid biosynthesis:Histidine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Metabolism:Environmental Information Processing:Small molecule interactions:Global:TCA cycle:Purine ribonucleotide biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino acid biosynthesis:Unknown function:Regulatory functions:Purines, pyrimidines, nucleosides, and nucleotides:Energy metabolism:Pyridine nucleotides:Histidine family:Nucleotide Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Metabolism of Cofactors and Vitamins:Information storage and processing:Biosynthesis of Other Secondary Metabolites:Environmental Information Processing:Membrane Transport:General:Global:Metabolism:Biosynthesis of Other Secondary Metabolites" 147 "" 148 "Energy production and conversion:Energy production and conversion:FAD/FMN-containing dehydrogenases:FAD/FMN-containing dehydrogenases:Biotin-(acetyl-CoA carboxylase) ligase:Biotin-(acetyl-CoA carboxylase) ligase:Lactoylglutathione lyase and related lyases:Lactoylglutathione lyase and related lyases:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Phosphoglycerate mutase 1:Phosphoglycerate mutase 1:Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Signal transduction histidine kinase:Signal transduction histidine kinase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Glutaredoxin and related proteins:Glutaredoxin and related proteins:FOG: CheY-like receiver:FOG: CheY-like receiver:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Ferredoxin:Ferredoxin:Methylase of chemotaxis methyl-accepting proteins:Methylase of chemotaxis methyl-accepting proteins:Ferritin-like protein:Ferritin-like protein:Flagellar basal body-associated protein:Flagellar basal body-associated protein:Heme/copper-type cytochrome/quinol oxidases, subunit 2:Heme/copper-type cytochrome/quinol oxidases, subunit 2:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein:Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:succinate dehydrogenase activity:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:sequence-specific DNA binding transcription factor activity:biotin-[acetyl-CoA-carboxylase] ligase activity:cytochrome-c oxidase activity:dihydropteroate synthase activity:ferroxidase activity:multicopper ferroxidase iron transport mediator activity:lactoylglutathione lyase activity:phosphoglycerate mutase activity:signal transducer activity:transporter activity:iron ion binding:copper ion binding:ATP binding:glycolysis:tricarboxylic acid cycle:electron transport:regulation of transcription, DNA-dependent:protein modification process:transport:iron ion transport:cellular iron ion homeostasis:chemotaxis:response to stress:signal transduction:ferric iron binding:protein-glutamate O-methyltransferase activity:electron carrier activity:folic acid-containing compound biosynthetic process:aa3-type cytochrome c oxidase:ba3-type cytochrome c oxidase:caa3-type cytochrome c oxidase:cbb3-type cytochrome c oxidase:protein disulfide oxidoreductase activity:oxidoreductase activity:peptidyl-histidine phosphorylation:pyruvate synthase activity:heme binding:cell redox homeostasis:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity:2-oxoglutarate synthase activity:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Oxidative phosphorylation:Oxidative phosphorylation:Butanoate metabolism:Butanoate metabolism:Methane metabolism:Methane metabolism:Biotin metabolism:Biotin metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:birA_ligase:birA_ligase:sensory_box:sensory_box:dhsB:dhsB:pgm_1:pgm_1:CoxB:CoxB:OAFO_sf:OAFO_sf:Global:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Carbohydrate Metabolism:Metabolism of Cofactors and Vitamins:Energy Metabolism:TCA cycle:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Protein fate:Regulatory functions:Energy metabolism:Energy Metabolism:Protein modification and repair:Small molecule interactions:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Electron transport:TCA cycle:Regulatory functions:Small molecule interactions:Protein fate:Protein modification and repair:Cellular processes and signaling:Metabolism:Poorly characterized:Electron transport" 149 "Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:ABC-type phosphate transport system, ATPase component:ABC-type phosphate transport system, ATPase component:Predicted metal-dependent hydrolase of the TIM-barrel fold:Predicted metal-dependent hydrolase of the TIM-barrel fold:two-component sensor activity:two-component signal transduction system (phosphorelay):catalytic activity:inorganic phosphate transmembrane transporter activity:ATP binding:regulation of transcription, DNA-dependent:phosphate ion transport:chemotaxis:metabolic process:phosphate ion transmembrane-transporting ATPase activity:ATPase activity:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:Poorly characterized:Cell Motility:Signal Transduction:Cellular Processes:Environmental Information Processing:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Cellular processes and signaling:Metabolism" 150 "Energy production and conversion:Energy production and conversion:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Glycerol dehydrogenase and related enzymes:Glycerol dehydrogenase and related enzymes:Glycosyltransferase:Glycosyltransferase:Alanine dehydrogenase:Alanine dehydrogenase:Glutamate racemase:Glutamate racemase:Pyridoxal phosphate biosynthesis protein:Pyridoxal phosphate biosynthesis protein:UDP-glucose 4-epimerase:UDP-glucose 4-epimerase:Ferredoxin:Ferredoxin:Flagellar biosynthesis/type III secretory pathway ATPase:Flagellar biosynthesis/type III secretory pathway ATPase:Uncharacterized membrane protein, required for N-linked glycosylation:Uncharacterized membrane protein, required for N-linked glycosylation:Uncharacterized protein predicted to be involved in DNA repair:Uncharacterized protein predicted to be involved in DNA repair:Type II secretory pathway, component PulD:Type II secretory pathway, component PulD:Uncharacterized protein predicted to be involved in DNA repair:Uncharacterized protein predicted to be involved in DNA repair:Coenzyme F390 synthetase:Coenzyme F390 synthetase:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Anti-sigma regulatory factor (Ser/Thr protein kinase):Anti-sigma regulatory factor (Ser/Thr protein kinase):Pyridoxal/pyridoxine/pyridoxamine kinase:Pyridoxal/pyridoxine/pyridoxamine kinase:Predicted membrane protein:Predicted membrane protein:Uncharacterized protein predicted to be involved in DNA repair:Uncharacterized protein predicted to be involved in DNA repair:Predicted dienelactone hydrolase:Predicted dienelactone hydrolase:Amino acid transport and metabolism:Amino acid transport and metabolism:alanine dehydrogenase activity:rhodopsin-like receptor activity:nucleic acid binding:catalytic activity:3-dehydroquinate synthase activity:DNA-directed DNA polymerase activity:hydrogen-transporting two-sector ATPase activity:UDP-glucose 4-epimerase activity:acetate-CoA ligase activity:oligosaccharyl transferase activity:dolichyl-diphosphooligosaccharide-protein glycotransferase activity:protein serine/threonine phosphatase activity:calcium-dependent protein serine/threonine phosphatase activity:magnesium-dependent protein serine/threonine phosphatase activity:transporter activity:ATP binding:GTP binding:polysaccharide metabolic process:electron transport:protein glycosylation:alanine metabolic process:transport:G-protein coupled receptor signaling pathway:metabolic process:CTD phosphatase activity:pyridoxal kinase activity:transaminase activity:calcium-dependent protein serine/threonine phosphatase regulator activity:pyridoxine biosynthetic process:glutamate racemase activity:mannose-1-phosphate guanylyltransferase (GDP) activity:electron carrier activity:biosynthetic process:aromatic amino acid family biosynthetic process:peptidoglycan biosynthetic process:protein secretion:protein transport:type III protein (virulence-related) secretor activity:ATP synthesis coupled proton transport:AMP binding:hydrolase activity:myosin phosphatase activity:myosin phosphatase regulator activity:pyridoxal phosphate binding:protein secretion by the type III secretion system:cellular metabolic process:nutrient reservoir activity:metal ion binding:hydrogen ion transporting ATP synthase activity, rotational mechanism:proton-transporting ATPase activity, rotational mechanism:phenylacetate-CoA ligase activity:2-oxoglutarate synthase activity:glycerol-1-phosphate dehydrogenase [NAD(P)+] activity:coenzyme binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Galactose metabolism:Galactose metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Taurine and hypotaurine metabolism:Taurine and hypotaurine metabolism:D-Glutamine and D-glutamate metabolism:D-Glutamine and D-glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Methane metabolism:Methane metabolism:Vitamin B6 metabolism:Vitamin B6 metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:glut_race:glut_race:cas1:cas1:alaDH:alaDH:pdxJ:pdxJ:fliI_yscN:fliI_yscN:cas2:cas2:cas_CT1132:cas_CT1132:Ac_CoA_lig_AcsA:Ac_CoA_lig_AcsA:type_III_yscC:type_III_yscC:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Pathogenesis:Mobile and extrachromosomal element functions:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridoxine:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing:Cell envelope:Biosynthesis of cofactors, prosthetic groups, and carriers:Mobile and extrachromosomal element functions:Cellular processes:Energy metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Pyridoxine:Other:Pathogenesis:ATP-proton motive force interconversion:Amino acids and amines:Global:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Other Amino Acids:Environmental Information Processing:Membrane Transport:Amino Acid Metabolism:Global:Metabolism:Energy Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Energy metabolism:Amino acids and amines:ATP-proton motive force interconversion:Cellular processes" 151 "Energy production and conversion:Energy production and conversion:Ribosomal protein S2:Ribosomal protein S2:Ribosomal protein L11:Ribosomal protein L11:Ribosomal protein L1:Ribosomal protein L1:DNA-directed RNA polymerase, beta' subunit/160 kD subunit:DNA-directed RNA polymerase, beta' subunit/160 kD subunit:Ribosomal protein L13:Ribosomal protein L13:Ribosomal protein S9:Ribosomal protein S9:Ribosomal protein L7/L12:Ribosomal protein L7/L12:Ribosomal protein L10:Ribosomal protein L10:Fe-S oxidoreductase:Fe-S oxidoreductase:Transcription antiterminator:Transcription antiterminator:Translation elongation factor Ts:Translation elongation factor Ts:Ribosomal protein S6:Ribosomal protein S6:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Preprotein translocase subunit SecE:Preprotein translocase subunit SecE:Predicted membrane GTPase involved in stress response:Predicted membrane GTPase involved in stress response:Ribosomal protein L25 (general stress protein Ctc):Ribosomal protein L25 (general stress protein Ctc):DNA binding:transcription elongation regulator activity:RNA binding:structural constituent of ribosome:translation elongation factor activity:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:GTPase activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:GTP binding:electron transport:transcription, DNA-dependent:regulation of transcription, DNA-dependent:translation:translational elongation:protein targeting:5S rRNA binding:protein-synthesizing GTPase activity:CDP-diacylglycerol diphosphatase activity:electron carrier activity:protein secretion:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:heme binding:ribosome biogenesis:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Metabolic pathways:Metabolic pathways:Ribosome:Ribosome:RNA polymerase:RNA polymerase:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Signal transduction mechanisms:Signal transduction mechanisms:tsf:tsf:S6:S6:small_GTP:small_GTP:ctc_TL5:ctc_TL5:L12:L12:nusG:nusG:secE_bact:secE_bact:rpsB_bact:rpsB_bact:rplM_bact:rplM_bact:rplA_bact:rplA_bact:L11_bact:L11_bact:rpoB:rpoB:rpoC_TIGR:rpoC_TIGR:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Cellular processes and signaling:Metabolism:Membrane Transport:Folding Sorting and Degradation:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:DNA-dependent RNA polymerase:Transcription factors:Ribosomal proteins: synthesis and modification:Translation factors:Protein and peptide secretion and trafficking:General:Transcription:Protein synthesis:Protein fate:Unknown function:Translation:Transcription:Nucleotide Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Nucleotide Metabolism:Genetic Information Processing:Transcription:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transcription:DNA-dependent RNA polymerase:Transcription factors:Protein synthesis:Ribosomal proteins: synthesis and modification:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Unknown function:General" 152 "Protease subunit of ATP-dependent Clp proteases:Protease subunit of ATP-dependent Clp proteases:Restriction endonuclease:Restriction endonuclease:Phage terminase, small subunit:Phage terminase, small subunit:Phage terminase-like protein, large subunit:Phage terminase-like protein, large subunit:Phage-related protein:Phage-related protein:Phage-related protein, tail component:Phage-related protein, tail component:Bacteriophage head-tail adaptor:Bacteriophage head-tail adaptor:nucleic acid binding:endonuclease activity:proteolysis:endopeptidase Clp activity:Replication, recombination and repair:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:General function prediction only:General function prediction only:Function unknown:Function unknown:portal_HK97:portal_HK97:sm_term_P27:sm_term_P27:gp16_SPP1:gp16_SPP1:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Mobile and extrachromosomal element functions:Prophage functions:Cellular processes and signaling:Information storage and processing:Poorly characterized:Cellular processes and signaling:Poorly characterized:Prophage functions:Mobile and extrachromosomal element functions:Information storage and processing" 153 "Energy production and conversion:Energy production and conversion:FAD/FMN-containing dehydrogenases:FAD/FMN-containing dehydrogenases:Exopolyphosphatase-related proteins:Exopolyphosphatase-related proteins:Multimeric flavodoxin WrbA:Multimeric flavodoxin WrbA:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Putative intracellular protease/amidase:Putative intracellular protease/amidase:Exonuclease III:Exonuclease III:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:NAD-dependent aldehyde dehydrogenases:NAD-dependent aldehyde dehydrogenases:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit:6Fe-6S prismane cluster-containing protein:6Fe-6S prismane cluster-containing protein:Predicted GTPase:Predicted GTPase:Uncharacterized conserved protein:Uncharacterized conserved protein:Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit:Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit:Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit:Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit:Delta 1-pyrroline-5-carboxylate dehydrogenase:Delta 1-pyrroline-5-carboxylate dehydrogenase:Amino acid transport and metabolism:Amino acid transport and metabolism:succinate dehydrogenase activity:nucleic acid binding:DNA binding:1-pyrroline-5-carboxylate dehydrogenase activity:aldehyde dehydrogenase [NAD(P)+] activity:endonuclease activity:proline dehydrogenase activity:transporter activity:carbohydrate metabolic process:electron transport:DNA repair:glutamate biosynthetic process:proline biosynthetic process:proline catabolic process:nitrogen compound metabolic process:transport:metabolic process:exodeoxyribonuclease III activity:succinate-semialdehyde dehydrogenase [NAD(P)+] activity:electron carrier activity:oxidoreductase activity:oxidoreductase activity, acting on other nitrogenous compounds as donors:transferase activity:hydrolase activity:hydrolase activity, acting on glycosyl bonds:pyruvate synthase activity:heme binding:manganese ion binding:thiamine pyrophosphate binding:nitrite reductase (cytochrome, ammonia-forming) activity:2-oxoglutarate synthase activity:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Oxidative phosphorylation:Oxidative phosphorylation:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Geraniol degradation:Geraniol degradation:Arginine and proline metabolism:Arginine and proline metabolism:Polycyclic aromatic hydrocarbon degradation:Polycyclic aromatic hydrocarbon degradation:Naphthalene degradation:Naphthalene degradation:Butanoate metabolism:Butanoate metabolism:Limonene and pinene degradation:Limonene and pinene degradation:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Base excision repair:Base excision repair:General function prediction only:General function prediction only:Function unknown:Function unknown:exoDNase_III:exoDNase_III:D1pyr5carbox2:D1pyr5carbox2:PfpI:PfpI:hybrid_clust:hybrid_clust:HEQRo_perm_3TM:HEQRo_perm_3TM:sdhA_frdA_Gneg:sdhA_frdA_Gneg:PorB_KorB:PorB_KorB:OAFO_sf:OAFO_sf:Poorly characterized:Xenobiotics Biodegradation and Metabolism:Global:Signal Transduction:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:Amino acids and amines:TCA cycle:DNA replication, recombination, and repair:Degradation of proteins, peptides, and glycopeptides:Amino acids, peptides and amines:Energy metabolism:DNA metabolism:Protein fate:Transport and binding proteins:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Replication and Repair:Metabolism:Energy metabolism:Amino acids and amines:TCA cycle:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Amino acids, peptides and amines:Information storage and processing:Cellular processes and signaling:Metabolism" 154 "Energy production and conversion:Energy production and conversion:Site-specific DNA methylase:Site-specific DNA methylase:Phosphate/sulphate permeases:Phosphate/sulphate permeases:Ni,Fe-hydrogenase maturation factor:Ni,Fe-hydrogenase maturation factor:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:Predicted permeases:Predicted permeases:Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain:Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain:Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase:Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase:Na+/H+ antiporter NhaD and related arsenite permeases:Na+/H+ antiporter NhaD and related arsenite permeases:ABC-type multidrug transport system, ATPase and permease components:ABC-type multidrug transport system, ATPase and permease components:Predicted metal-dependent hydrolase:Predicted metal-dependent hydrolase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Lipid A core - O-antigen ligase and related enzymes:Lipid A core - O-antigen ligase and related enzymes:Amino acid transport and metabolism:Amino acid transport and metabolism:DNA binding:DNA (cytosine-5-)-methyltransferase activity:transporter activity:inorganic phosphate transmembrane transporter activity:ATP binding:DNA methylation:regulation of transcription, DNA-dependent:transport:phosphate ion transport:enzyme activator activity:peptidase activity:lipid biosynthetic process:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity:citrate transmembrane transporter activity:citrate transport:ATPase activity, coupled to transmembrane movement of substances:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:hydrog_prot:hydrog_prot:dcm:dcm:HEQRo_perm_3TM:HEQRo_perm_3TM:lipid_A_lpxA:lipid_A_lpxA:Defense mechanisms:Defense mechanisms:DNA replication, recombination, and repair:Transport and binding proteins:Amino acids, peptides and amines:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cell envelope:Transport and binding proteins:DNA metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Amino acids, peptides and amines:DNA replication, recombination, and repair:Global:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Poorly characterized:Glycan Biosynthesis and Metabolism:Metabolism:Environmental Information Processing:Membrane Transport:Cellular processes and signaling:Global:Metabolism:Information storage and processing:DNA metabolism" 155 "Energy production and conversion:Energy production and conversion:Folylpolyglutamate synthase:Folylpolyglutamate synthase:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:Predicted Zn-dependent peptidases:Predicted Zn-dependent peptidases:Phosphate uptake regulator:Phosphate uptake regulator:Periplasmic protein TonB, links inner and outer membranes:Periplasmic protein TonB, links inner and outer membranes:Biopolymer transport proteins:Biopolymer transport proteins:Heme/copper-type cytochrome/quinol oxidases, subunit 1:Heme/copper-type cytochrome/quinol oxidases, subunit 1:Biopolymer transport protein:Biopolymer transport protein:ABC-type multidrug transport system, ATPase component:ABC-type multidrug transport system, ATPase component:Heterodisulfide reductase, subunit A and related polyferredoxins:Heterodisulfide reductase, subunit A and related polyferredoxins:Alcohol dehydrogenase, class IV:Alcohol dehydrogenase, class IV:Uncharacterized conserved protein:Uncharacterized conserved protein:Coenzyme F420-reducing hydrogenase, delta subunit:Coenzyme F420-reducing hydrogenase, delta subunit:Heterodisulfide reductase, subunit B:Heterodisulfide reductase, subunit B:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:ABC-type oligopeptide transport system, periplasmic component:ABC-type oligopeptide transport system, periplasmic component:ABC-type uncharacterized transport system, duplicated ATPase component:ABC-type uncharacterized transport system, duplicated ATPase component:ABC-type uncharacterized transport system, permease component:ABC-type uncharacterized transport system, permease component:ABC-type uncharacterized transport system, permease component:ABC-type uncharacterized transport system, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:cytochrome-c oxidase activity:metalloendopeptidase activity:tetrahydrofolylpolyglutamate synthase activity:transporter activity:iron ion transmembrane transporter activity:iron ion binding:ATP binding:electron transport:pyrimidine nucleotide biosynthetic process:DNA recombination:regulation of transcription, DNA-dependent:proteolysis:transport:iron ion transport:signal transduction:tRNA processing:transcription factor binding:metabolic process:zinc ion binding:protein transporter activity:dihydrofolate synthase activity:electron carrier activity:aerobic respiration:folic acid-containing compound biosynthetic process:aa3-type cytochrome c oxidase:ba3-type cytochrome c oxidase:caa3-type cytochrome c oxidase:cbb3-type cytochrome c oxidase:protein transport:methanogenesis:oxidoreductase activity:ATPase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:heme binding:metal ion binding:transition metal ion binding:flavin adenine dinucleotide binding:iron-sulfur cluster binding:2 iron, 2 sulfur cluster binding:CoB--CoM heterodisulfide reductase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Fatty acid metabolism:Fatty acid metabolism:Oxidative phosphorylation:Oxidative phosphorylation:Tyrosine metabolism:Tyrosine metabolism:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Naphthalene degradation:Naphthalene degradation:Methane metabolism:Methane metabolism:Folate biosynthesis:Folate biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:tonB_Cterm:tonB_Cterm:folC:folC:phoU_full:phoU_full:CtaD_CoxA:CtaD_CoxA:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Metabolism:Energy metabolism:Transport and binding proteins:Biosynthesis of cofactors, prosthetic groups, and carriers:Anions:Electron transport:Global:Environmental Information Processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Transport and binding proteins:Anions:Cations and iron carrying compounds:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Cellular processes and signaling:Folic acid:Poorly characterized:Metabolism:Metabolism:Membrane Transport:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Cations and iron carrying compounds" 156 "ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:Uncharacterized conserved protein:Uncharacterized conserved protein:Phage shock protein A (IM30), suppresses sigma54-dependent transcription:Phage shock protein A (IM30), suppresses sigma54-dependent transcription:Putative stress-responsive transcriptional regulator:Putative stress-responsive transcriptional regulator:Predicted transcriptional regulator:Predicted transcriptional regulator:ABC-type branched-chain amino acid transport system, permease component:ABC-type branched-chain amino acid transport system, permease component:Site-specific recombinase XerD:Site-specific recombinase XerD:Amino acid transport and metabolism:Amino acid transport and metabolism:DNA binding:transporter activity:binding:ATP binding:DNA recombination:transport:response to salt stress:DNA integration:transcription repressor activity:ATPase activity:sequence-specific DNA binding:negative regulation of transcription, DNA-dependent:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:ABC transporters:ABC transporters:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:phageshock_pspB:phageshock_pspB:phageshock_pspA:phageshock_pspA:phageshock_pspC:phageshock_pspC:Cellular processes and signaling:Metabolism:Poorly characterized:Membrane Transport:Environmental Information Processing:Adaptations to atypical conditions:Poorly characterized:Environmental Information Processing:Membrane Transport:Metabolism:Cellular processes and signaling:Information storage and processing:Cellular processes:Cellular processes:Adaptations to atypical conditions:Information storage and processing" 157 "Energy production and conversion:Energy production and conversion:Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Predicted transcriptional regulators:Predicted transcriptional regulators:ABC-type molybdate transport system, periplasmic component:ABC-type molybdate transport system, periplasmic component:FOG: CheY-like receiver:FOG: CheY-like receiver:L-lactate permease:L-lactate permease:Aldehyde:ferredoxin oxidoreductase:Aldehyde:ferredoxin oxidoreductase:Predicted transcriptional regulator:Predicted transcriptional regulator:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Outer membrane lipoprotein:Outer membrane lipoprotein:Selenocysteine-specific translation elongation factor:Selenocysteine-specific translation elongation factor:Predicted transcriptional regulator:Predicted transcriptional regulator:two-component response regulator activity:two-component signal transduction system (phosphorelay):selenocysteine incorporation:DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:translation elongation factor activity:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity:GTPase activity:ATP binding:GTP binding:cellular aldehyde metabolic process:electron transport:regulation of transcription, DNA-dependent:response to stress:zinc ion binding:pyruvate, water dikinase activity:lactate transmembrane transporter activity:molybdate transmembrane-transporting ATPase activity:molybdate ion transport:lactate transport:phosphorylation:transcription repressor activity:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor:aldehyde ferredoxin oxidoreductase activity:sequence-specific DNA binding:negative regulation of transcription, DNA-dependent:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:small_GTP:small_GTP:lctP:lctP:modA:modA:General:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Anions:Carbohydrates, organic alcohols, and acids:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Anions:Global:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Unknown function:Transport and binding proteins:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism" 158 "ATP-dependent Zn proteases:ATP-dependent Zn proteases:ATP-dependent Lon protease, bacterial type:ATP-dependent Lon protease, bacterial type:Zn-dependent hydrolases, including glyoxylases:Zn-dependent hydrolases, including glyoxylases:Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:ATPases with chaperone activity, ATP-binding subunit:ATPases with chaperone activity, ATP-binding subunit:Integral membrane protein, interacts with FtsH:Integral membrane protein, interacts with FtsH:Predicted membrane-associated Zn-dependent proteases 1:Predicted membrane-associated Zn-dependent proteases 1:ATP-dependent protease Clp, ATPase subunit:ATP-dependent protease Clp, ATPase subunit:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:catalytic activity:ATP-dependent peptidase activity:metalloendopeptidase activity:aspartate-tRNA ligase activity:protein binding:ATP binding:electron transport:DNA repair:DNA recombination:proteolysis:ATP-dependent proteolysis:metabolic process:zinc ion binding:endopeptidase Clp activity:endopeptidase La activity:electron carrier activity:four-way junction helicase activity:protein transport:hydrolase activity:ATPase activity:nucleoside-triphosphatase activity:protein metabolic process:protein catabolic process:protein dimerization activity:chaperone mediated protein folding requiring cofactor:iron-sulfur cluster binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:General function prediction only:General function prediction only:Function unknown:Function unknown:TIGR00054:TIGR00054:clpX:clpX:lon:lon:FtsH_fam:FtsH_fam:IV_pilin_GFxxxE:IV_pilin_GFxxxE:ClpA:ClpA:chaperone_ClpB:chaperone_ClpB:rSAM_NirJ1:rSAM_NirJ1:Protein folding and stabilization:Protein fate:Protein folding and stabilization:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Cellular processes and signaling:Poorly characterized:Poorly characterized:Cellular processes and signaling:Protein fate:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking" 159 "Predicted transcriptional regulator:Predicted transcriptional regulator:DNA binding:transposase activity:transposition, DNA-mediated:transcription repressor activity:sequence-specific DNA binding:negative regulation of transcription, DNA-dependent:Transcription:Transcription:Information storage and processing:Information storage and processing" 160 "Energy production and conversion:Energy production and conversion:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Cobalamin-5-phosphate synthase:Cobalamin-5-phosphate synthase:Serine/threonine protein kinase:Serine/threonine protein kinase:Na+-driven multidrug efflux pump:Na+-driven multidrug efflux pump:Transcriptional regulator:Transcriptional regulator:Predicted ATPase with chaperone activity:Predicted ATPase with chaperone activity:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases:L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases:Uncharacterized conserved protein:Uncharacterized conserved protein:Transcriptional regulators:Transcriptional regulators:ABC-type Co2+ transport system, periplasmic component:ABC-type Co2+ transport system, periplasmic component:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:fatty-acyl-CoA binding:DNA binding:sequence-specific DNA binding transcription factor activity:protein serine/threonine kinase activity:protein tyrosine kinase activity:ATP binding:electron transport:DNA-dependent DNA replication initiation:regulation of transcription, DNA-dependent:protein phosphorylation:drug transmembrane transport:DNA-dependent ATPase activity:metabolic process:cobalamin 5'-phosphate synthase activity:cobalamin biosynthetic process:FMN binding:drug transmembrane transporter activity:antiporter activity:photosynthesis:chlorophyll biosynthetic process:oxidoreductase activity:transferase activity:magnesium chelatase activity:regulation of fatty acid metabolic process:methylamine metabolic process:adenosylcobinamide-GDP ribazoletransferase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyruvate metabolism:Pyruvate metabolism:Methane metabolism:Methane metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00368:TIGR00368:matE:matE:Defense mechanisms:Defense mechanisms:Unknown function:Transport and binding proteins:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Transport and binding proteins:Other:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Other:Global:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Energy Metabolism:Carbohydrate Metabolism" 161 "Energy production and conversion:Energy production and conversion:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Nucleotidyltransferase/DNA polymerase involved in DNA repair:ABC-type uncharacterized transport system, permease component:ABC-type uncharacterized transport system, permease component:Molybdopterin biosynthesis enzymes:Molybdopterin biosynthesis enzymes:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Flp pilus assembly protein TadC:Flp pilus assembly protein TadC:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Putative hemolysin:Putative hemolysin:Urea transporter:Urea transporter:Flp pilus assembly protein TadB:Flp pilus assembly protein TadB:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA-directed DNA polymerase activity:purine-nucleoside phosphorylase activity:transporter activity:binding:ATP binding:electron transport:DNA repair:regulation of transcription, DNA-dependent:Mo-molybdopterin cofactor biosynthetic process:transport:4-alpha-hydroxytetrahydrobiopterin dehydratase activity:transcription factor binding:metabolic process:electron carrier activity:protein secretion:urea transmembrane transporter activity:nickel-transporting ATPase activity:urea transport:transferase activity, transferring acyl groups:hydrolase activity, acting on ester bonds:nucleoside-triphosphatase activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Thiamine metabolism:Thiamine metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:DNA replication:DNA replication:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:Sulfur relay system:Sulfur relay system:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:molyb_syn:molyb_syn:TIGR00245:TIGR00245:thiF_fam2:thiF_fam2:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Environmental Information Processing:Membrane Transport:Genetic Information Processing:Global:Metabolism:Environmental Information Processing:Nucleotide Metabolism:Energy Metabolism:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Membrane Transport:Replication and Repair:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Poorly characterized:Energy Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Cellular processes and signaling:Information storage and processing:Global:Conserved:Thiamine:Hypothetical proteins:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Metabolism:Metabolism of Cofactors and Vitamins" 162 "Energy production and conversion:Energy production and conversion:Acetyltransferase (isoleucine patch superfamily):Acetyltransferase (isoleucine patch superfamily):Fumarase:Fumarase:N-methylhydantoinase A/acetone carboxylase, beta subunit:N-methylhydantoinase A/acetone carboxylase, beta subunit:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Acyl-CoA synthetase (NDP forming):Acyl-CoA synthetase (NDP forming):ABC-type Mn2+/Zn2+ transport systems, permease components:ABC-type Mn2+/Zn2+ transport systems, permease components:Glycosyltransferases, probably involved in cell wall biogenesis:Glycosyltransferases, probably involved in cell wall biogenesis:Protoporphyrinogen oxidase:Protoporphyrinogen oxidase:ABC-type Na+ efflux pump, permease component:ABC-type Na+ efflux pump, permease component:Uncharacterized conserved protein:Uncharacterized conserved protein:Selenocysteine synthase [seryl-tRNASer selenium transferase]:Selenocysteine synthase [seryl-tRNASer selenium transferase]:Membrane protein involved in the export of O-antigen and teichoic acid:Membrane protein involved in the export of O-antigen and teichoic acid:Putative homoserine kinase type II (protein kinase fold):Putative homoserine kinase type II (protein kinase fold):Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:ABC-type spermidine/putrescine transport systems, ATPase components:ABC-type spermidine/putrescine transport systems, ATPase components:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Putative secretion activating protein:Putative secretion activating protein:Predicted membrane protein:Predicted membrane protein:Phage-related holin (Lysis protein):Phage-related holin (Lysis protein):Signal transduction histidine kinase:Signal transduction histidine kinase:Predicted rRNA methylase:Predicted rRNA methylase:Bacteriophage tail assembly protein:Bacteriophage tail assembly protein:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):polysaccharide biosynthetic process:selenocysteine incorporation:DNA binding:sequence-specific DNA binding transcription factor activity:DNA-directed DNA polymerase activity:L-seryl-tRNASec selenium transferase activity:fumarate hydratase activity:succinate-CoA ligase (ADP-forming) activity:signal transducer activity:binding:iron ion binding:calcium ion binding:ATP binding:tricarboxylic acid cycle:fumarate metabolic process:electron transport:DNA repair:regulation of transcription, DNA-dependent:transport:signal transduction:N-acetyltransferase activity:transcription factor binding:metabolic process:UDP-galactopyranose mutase activity:electron carrier activity:putrescine-importing ATPase activity:spermidine-importing ATPase activity:selenocysteine biosynthetic process:oxidoreductase activity:amino acid binding:transferase activity:transferase activity, transferring acyl groups:hydrolase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:heme binding:pyridoxal phosphate binding:ATPase activity, coupled to transmembrane movement of substances:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Selenocompound metabolism:Selenocompound metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:selA:selA:fumC_II:fumC_II:holin_tox_secr:holin_tox_secr:Information storage and processing:Metabolism of Other Amino Acids:Carbohydrate Metabolism:Translation:Metabolism:Mobile and extrachromosomal element functions:Protein synthesis:Regulatory functions:Energy metabolism:Prophage functions:tRNA aminoacylation:Small molecule interactions:TCA cycle:Global:Genetic Information Processing:Metabolism of Other Amino Acids:Carbohydrate Metabolism:Metabolism:Genetic Information Processing:Translation:Metabolism:Global:Metabolism:Energy metabolism:TCA cycle:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA aminoacylation:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Poorly characterized:Metabolism:Cellular processes and signaling" 163 "Superfamily II DNA and RNA helicases:Superfamily II DNA and RNA helicases:Exopolyphosphatase-related proteins:Exopolyphosphatase-related proteins:ABC-type transport system involved in resistance to organic solvents, permease component:ABC-type transport system involved in resistance to organic solvents, permease component:Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis):Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis):N-acetylmuramoyl-L-alanine amidase:N-acetylmuramoyl-L-alanine amidase:ABC-type polysaccharide/polyol phosphate transport system, ATPase component:ABC-type polysaccharide/polyol phosphate transport system, ATPase component:Mg/Co/Ni transporter MgtE (contains CBS domain):Mg/Co/Ni transporter MgtE (contains CBS domain):Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:recombinase activity:nucleic acid binding:DNA binding:catalytic activity:nuclease activity:binding:electron transporter activity:copper ion binding:ATP binding:electron transport:DNA repair:DNA recombination:cation transport:ATP-dependent helicase activity:metabolic process:cation transmembrane transporter activity:N-acetylmuramoyl-L-alanine amidase activity:electron carrier activity:peptidoglycan catabolic process:hydrolase activity:ATPase activity:manganese ion binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:ABC transporters:ABC transporters:RNA degradation:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:TIGR00056:TIGR00056:RNAse_H_YqgF:RNAse_H_YqgF:Cellular processes and signaling:Metabolism:Poorly characterized:Hypothetical proteins:General:Conserved:Environmental Information Processing:Genetic Information Processing:Membrane Transport:Folding Sorting and Degradation:Unknown function:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Hypothetical proteins:Conserved:Unknown function:General:Information storage and processing" 164 "Molecular chaperone (small heat shock protein):Molecular chaperone (small heat shock protein):Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:Thiamine monophosphate kinase:Thiamine monophosphate kinase:Sec-independent protein secretion pathway component TatC:Sec-independent protein secretion pathway component TatC:Putative transcriptional regulator, homolog of Bvg accessory factor:Putative transcriptional regulator, homolog of Bvg accessory factor:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:Methylase involved in ubiquinone/menaquinone biosynthesis:Methylase involved in ubiquinone/menaquinone biosynthesis:Surface lipoprotein:Surface lipoprotein:nucleotide binding:catalytic activity:DNA-directed DNA polymerase activity:pantothenate kinase activity:metabolic process:methyltransferase activity:dTDP-4-dehydrorhamnose 3,5-epimerase activity:thiamine-phosphate kinase activity:lipopolysaccharide biosynthetic process:coenzyme biosynthetic process:thiamine biosynthetic process:transcription activator activity:positive regulation of transcription, DNA-dependent:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Ubiquinone and other terpenoid-quinone biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Streptomycin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Polyketide sugar unit biosynthesis:Thiamine metabolism:Thiamine metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:baf:baf:tatC:tatC:thiL:thiL:MenG_MenH_UbiE:MenG_MenH_UbiE:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis of Other Secondary Metabolites:Poorly characterized:Genetic Information Processing:Folding Sorting and Degradation:Metabolism:Environmental Information Processing:Membrane Transport:Cellular processes and signaling:Global:Metabolism:Information storage and processing:Biosynthesis of cofactors, prosthetic groups, and carriers:Protein fate:Thiamine:Metabolism of Cofactors and Vitamins:Protein fate:Protein and peptide secretion and trafficking:Biosynthesis of cofactors, prosthetic groups, and carriers:Menaquinone and ubiquinone:Pantothenate and coenzyme A:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Pantothenate and coenzyme A:Menaquinone and ubiquinone:Protein and peptide secretion and trafficking:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Folding Sorting and Degradation:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Metabolism" 165 "Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB:Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB:Bacteriophage tail assembly protein:Bacteriophage tail assembly protein:Amino acid transport and metabolism:Amino acid transport and metabolism:sequence-specific DNA binding:General function prediction only:General function prediction only:Metabolism:Poorly characterized:Poorly characterized:Metabolism" 166 "Energy production and conversion:Energy production and conversion:NAD synthase:NAD synthase:NAD-dependent DNA ligase (contains BRCT domain type II):NAD-dependent DNA ligase (contains BRCT domain type II):FAD/FMN-containing dehydrogenases:FAD/FMN-containing dehydrogenases:Nucleoside-diphosphate-sugar epimerases:Nucleoside-diphosphate-sugar epimerases:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:Prolipoprotein diacylglyceryltransferase:Prolipoprotein diacylglyceryltransferase:Phosphatidylserine decarboxylase:Phosphatidylserine decarboxylase:tmRNA-binding protein:tmRNA-binding protein:Putative intracellular protease/amidase:Putative intracellular protease/amidase:Thioredoxin-like proteins and domains:Thioredoxin-like proteins and domains:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:Cation/multidrug efflux pump:Cation/multidrug efflux pump:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Transcriptional regulator:Transcriptional regulator:N-acetylglutamate synthase (N-acetylornithine aminotransferase):N-acetylglutamate synthase (N-acetylornithine aminotransferase):L-lactate permease:L-lactate permease:Phosphotransferase system, HPr-related proteins:Phosphotransferase system, HPr-related proteins:Uncharacterized bacitracin resistance protein:Uncharacterized bacitracin resistance protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted methyltransferase:Predicted methyltransferase:Tfp pilus assembly protein, pilus retraction ATPase PilT:Tfp pilus assembly protein, pilus retraction ATPase PilT:Precorrin-4 methylase:Precorrin-4 methylase:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:rRNA modification:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):rRNA (adenine-N6,N6-)-dimethyltransferase activity:DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:peptidyl-prolyl cis-trans isomerase activity:DNA ligase (NAD+) activity:NAD+ synthase (glutamine-hydrolyzing) activity:acetyl-CoA:L-glutamate N-acetyltransferase activity:formate-tetrahydrofolate ligase activity:glutamate N-acetyltransferase activity:cyclophilin:phosphatidylserine decarboxylase activity:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity:transporter activity:sugar:hydrogen symporter activity:iron ion binding:ATP binding:carbohydrate metabolic process:DNA replication:DNA repair:regulation of transcription, DNA-dependent:translation:protein folding:protein modification process:arginine biosynthetic process:nitrogen compound metabolic process:transport:protein methyltransferase activity:phospholipid biosynthetic process:ADP-glyceromanno-heptose 6-epimerase activity:NAD+ synthase activity:glycolate oxidase activity:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity:undecaprenol kinase activity:biosynthetic process:cobalamin biosynthetic process:protein lipoylation:phosphoenolpyruvate-dependent sugar phosphotransferase system:NAD biosynthetic process:protein transport:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:iron-sulfur cluster assembly:oxidoreductase activity:specific transcriptional repressor activity:transferase activity:hydrolase activity, acting on glycosyl bonds:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:FK506-sensitive peptidyl-prolyl cis-trans isomerase:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:sequence-specific DNA binding:cellular metabolic process:negative regulation of transcription, DNA-dependent:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity:precorrin-4 C11-methyltransferase activity:glucose-1-phosphate cytidylyltransferase activity:nucleoside-triphosphate diphosphatase activity:undecaprenyl-diphosphatase activity:flavin adenine dinucleotide binding:NADP binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:DNA replication:DNA replication:Base excision repair:Base excision repair:Nucleotide excision repair:Nucleotide excision repair:Mismatch repair:Mismatch repair:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:smpB:smpB:ArgJ:ArgJ:PS_decarb_rel:PS_decarb_rel:mazG:mazG:lgt:lgt:nadE:nadE:dnlj:dnlj:undec_PP_bacA:undec_PP_bacA:PTS_HPr_family:PTS_HPr_family:PfpI:PfpI:pilT_fam:pilT_fam:cobM_cbiF:cobM_cbiF:HEQRo_perm_3TM:HEQRo_perm_3TM:heptose_epim:heptose_epim:CbiE:CbiE:G1P_cyt_trans:G1P_cyt_trans:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Lipid Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Replication and Repair:Membrane Transport:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:DNA replication, recombination, and repair:Other:Degradation of proteins, peptides, and glycopeptides:Protein modification and repair:Amino acids, peptides and amines:Chemotaxis and motility:General:Glutamate family:Heme, porphyrin, and cobalamin:Pyridine nucleotides:PTS:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:DNA metabolism:Protein synthesis:Protein fate:Transport and binding proteins:Cellular processes:Unknown function:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Signal transduction:Cell envelope:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Other:Protein fate:Degradation of proteins, peptides, and glycopeptides:Protein modification and repair:Transport and binding proteins:Amino acids, peptides and amines:Cellular processes:Chemotaxis and motility:Unknown function:General:Amino acid biosynthesis:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Pyridine nucleotides:Signal transduction:PTS:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Nucleotide Metabolism" 167 "Energy production and conversion:Energy production and conversion:Anaerobic dehydrogenases, typically selenocysteine-containing:Anaerobic dehydrogenases, typically selenocysteine-containing:Thioredoxin reductase:Thioredoxin reductase:Predicted permeases:Predicted permeases:Acetyltransferases, including N-acetylases of ribosomal proteins:Acetyltransferases, including N-acetylases of ribosomal proteins:Flp pilus assembly protein TadG:Flp pilus assembly protein TadG:protein disulfide isomerase activity:thioredoxin-disulfide reductase activity:electron transport:glycerol ether metabolic process:metabolic process:formate dehydrogenase (NAD+) activity:ribosomal-protein-alanine N-acetyltransferase activity:electron carrier activity:thiamine biosynthetic process:protein disulfide oxidoreductase activity:removal of superoxide radicals:molybdenum ion binding:cellular respiration:cell redox homeostasis:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Pyrimidine metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:thioredoxin:thioredoxin:TAT_signal_seq:TAT_signal_seq:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Electron transport:Protein fate:Protein and peptide secretion and trafficking:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Nucleotide Metabolism:Energy Metabolism:Metabolism:Metabolism:Global:Electron transport:Protein and peptide secretion and trafficking:Energy metabolism:Protein fate:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Global:Metabolism:Energy metabolism" 168 "ABC-type phosphate transport system, ATPase component:ABC-type phosphate transport system, ATPase component:HrpA-like helicases:HrpA-like helicases:nucleic acid binding:helicase activity:inorganic phosphate transmembrane transporter activity:ATP binding:phosphate ion transport:phosphate ion transmembrane-transporting ATPase activity:ATPase activity:Replication, recombination and repair:Replication, recombination and repair:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:psiM2_ORF9:psiM2_ORF9:DEAH_box_HrpB:DEAH_box_HrpB:Unknown function:Enzymes of unknown specificity:Information storage and processing:Metabolism:Prophage functions:Mobile and extrachromosomal element functions:Enzymes of unknown specificity:Unknown function:Information storage and processing:Metabolism:Mobile and extrachromosomal element functions:Prophage functions" 169 "Energy production and conversion:Energy production and conversion:Riboflavin synthase beta-chain:Riboflavin synthase beta-chain:Glycine/serine hydroxymethyltransferase:Glycine/serine hydroxymethyltransferase:Ribosomal protein L28:Ribosomal protein L28:Acyl carrier protein:Acyl carrier protein:Fe-S oxidoreductase:Fe-S oxidoreductase:3-oxoacyl-(acyl-carrier-protein) synthase:3-oxoacyl-(acyl-carrier-protein) synthase:Riboflavin synthase alpha chain:Riboflavin synthase alpha chain:3-oxoacyl-[acyl-carrier-protein] synthase III:3-oxoacyl-[acyl-carrier-protein] synthase III:Ribosomal protein L32:Ribosomal protein L32:Leucyl-tRNA synthetase:Leucyl-tRNA synthetase:UDP-N-acetyl-D-mannosaminuronate dehydrogenase:UDP-N-acetyl-D-mannosaminuronate dehydrogenase:Uncharacterized conserved protein containing a ferredoxin-like domain:Uncharacterized conserved protein containing a ferredoxin-like domain:Predicted metal-binding, possibly nucleic acid-binding protein:Predicted metal-binding, possibly nucleic acid-binding protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Pyrimidine reductase, riboflavin biosynthesis:Pyrimidine reductase, riboflavin biosynthesis:Multiple antibiotic transporter:Multiple antibiotic transporter:Deoxycytidylate deaminase:Deoxycytidylate deaminase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Short-chain alcohol dehydrogenase of unknown specificity:Short-chain alcohol dehydrogenase of unknown specificity:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:acyl carrier activity:structural constituent of ribosome:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:dCMP deaminase activity:3-oxoacyl-[acyl-carrier-protein] synthase activity:glycine hydroxymethyltransferase activity:ribonuclease III activity:phosphogluconate dehydrogenase (decarboxylating) activity:riboflavin synthase activity:leucine-tRNA ligase activity:ATP binding:pentose-phosphate shunt:electron transport:translation:leucyl-tRNA aminoacylation:glycine metabolic process:L-serine metabolic process:fatty acid biosynthetic process:NADH dehydrogenase (ubiquinone) activity:metabolic process:zinc ion binding:5-amino-6-(5-phosphoribosylamino)uracil reductase activity:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity:glycolate oxidase activity:electron carrier activity:biosynthetic process:riboflavin biosynthetic process:folic acid-containing compound biosynthetic process:oxidoreductase activity:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:pyridoxal phosphate binding:5-formyltetrahydrofolate cyclo-ligase activity:heat shock protein binding:phosphopantetheine binding:cellular metabolic process:glycerol-3-phosphate catabolic process:cofactor binding:coenzyme binding:NAD binding:iron-sulfur cluster binding:CoB--CoM heterodisulfide reductase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Fatty acid biosynthesis:Fatty acid biosynthesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:One carbon pool by folate:Methane metabolism:Methane metabolism:Riboflavin metabolism:Riboflavin metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Biosynthesis of unsaturated fatty acids:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Ribosome:Ribosome:DNA replication:DNA replication:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:L28:L28:lumazine-synth:lumazine-synth:ribE:ribE:TIGR00273:TIGR00273:eubact_ribD:eubact_ribD:leuS_bact:leuS_bact:TIGR00427:TIGR00427:acyl_carrier:acyl_carrier:fabH:fabH:rpmF_bact:rpmF_bact:NDP-sugDHase:NDP-sugDHase:fabF:fabF:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Unknown function:Energy metabolism:Electron transport:Fatty acid and phospholipid metabolism:Biosynthesis:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Protein synthesis:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:General:Riboflavin, FMN, and FAD:Energy metabolism:Fatty acid and phospholipid metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism of Cofactors and Vitamins:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Genetic Information Processing:Translation:Translation:Amino Acid Metabolism:Replication and Repair:Replication and Repair:Metabolism:Nucleotide Metabolism:Global:Metabolism:Metabolism:Lipid Metabolism:Genetic Information Processing:Energy Metabolism:Global:Electron transport" 170 "Acyl carrier protein phosphodiesterase:Acyl carrier protein phosphodiesterase:Flagellar motor component:Flagellar motor component:Transcriptional regulator:Transcriptional regulator:Predicted transcriptional regulator:Predicted transcriptional regulator:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Chloramphenicol O-acetyltransferase:Chloramphenicol O-acetyltransferase:sequence-specific DNA binding transcription factor activity:signal transducer activity:iron ion binding:ATP binding:electron transport:regulation of transcription, DNA-dependent:transport:signal transduction:transcription factor binding:protein transporter activity:chloramphenicol O-acetyltransferase activity:electron carrier activity:oxidoreductase activity:specific transcriptional repressor activity:nucleoside-triphosphatase activity:heme binding:negative regulation of transcription, DNA-dependent:coenzyme binding:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Cell motility:Cell motility:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:rrf2_super:rrf2_super:Defense mechanisms:Defense mechanisms:Signal Transduction:Environmental Information Processing:Metabolism:Cellular processes and signaling:Regulatory functions:Small molecule interactions:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Information storage and processing:Unknown function:Regulatory functions:General:Small molecule interactions:Cellular Processes:Environmental Information Processing:Cell Motility:Cellular Processes:Signal Transduction:Cell Motility" 171 "Predicted Co/Zn/Cd cation transporters:Predicted Co/Zn/Cd cation transporters:FOG: CheY-like receiver:FOG: CheY-like receiver:Predicted thioesterase:Predicted thioesterase:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:Protein-L-isoaspartate carboxylmethyltransferase:Protein-L-isoaspartate carboxylmethyltransferase:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:nucleic acid binding:DNA binding:peptidyl-prolyl cis-trans isomerase activity:ribonuclease P activity:cyclophilin:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity:transposase activity:transposition, DNA-mediated:regulation of transcription, DNA-dependent:RNA processing:protein modification process:cation transport:tRNA processing:cation transmembrane transporter activity:dTDP-4-dehydrorhamnose 3,5-epimerase activity:lipopolysaccharide biosynthetic process:hydrolase activity:FK506-sensitive peptidyl-prolyl cis-trans isomerase:protein repair:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:sequence-specific DNA binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Polyketide sugar unit biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00051:TIGR00051:pimt:pimt:rnpA:rnpA:rmlC:rmlC:CDF:CDF:Poorly characterized:Metabolism:Metabolism of Terpenoids and Polyketides:Transcription:Biosynthesis of Other Secondary Metabolites:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Environmental Information Processing:Signal Transduction:General:Cellular Processes:Cell Motility:Cations and iron carrying compounds:Global:Metabolism:Protein modification and repair:RNA processing:Global:Cellular Processes:Transcription:RNA processing:Protein fate:Protein modification and repair:Transport and binding proteins:Cations and iron carrying compounds:Unknown function:General:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Metabolism:Metabolism:Cell envelope:Signal Transduction:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Cell Motility:Unknown function:Transport and binding proteins:Protein fate:Cellular processes and signaling:Metabolism" 172 "Energy production and conversion:Energy production and conversion:Acetylglutamate semialdehyde dehydrogenase:Acetylglutamate semialdehyde dehydrogenase:Xaa-Pro aminopeptidase:Xaa-Pro aminopeptidase:Isopropylmalate/homocitrate/citramalate synthases:Isopropylmalate/homocitrate/citramalate synthases:Aspartate-semialdehyde dehydrogenase:Aspartate-semialdehyde dehydrogenase:Geranylgeranyl pyrophosphate synthase:Geranylgeranyl pyrophosphate synthase:Guanylate kinase:Guanylate kinase:Ribonucleotide reductase, alpha subunit:Ribonucleotide reductase, alpha subunit:Glycosyltransferase:Glycosyltransferase:Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains:Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:DNA polymerase III, alpha subunit:DNA polymerase III, alpha subunit:Predicted hydrolase of the metallo-beta-lactamase superfamily:Predicted hydrolase of the metallo-beta-lactamase superfamily:2-methylthioadenine synthetase:2-methylthioadenine synthetase:Collagenase and related proteases:Collagenase and related proteases:Mannose-1-phosphate guanylyltransferase:Mannose-1-phosphate guanylyltransferase:Predicted SAM-dependent methyltransferases:Predicted SAM-dependent methyltransferases:Uncharacterized stress-induced protein:Uncharacterized stress-induced protein:Predicted CoA-binding protein:Predicted CoA-binding protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:succinate dehydrogenase activity:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:DNA binding:RNA binding:2-isopropylmalate synthase activity:DNA-directed DNA polymerase activity:N-acetyl-gamma-glutamyl-phosphate reductase activity:aspartate-semialdehyde dehydrogenase activity:X-Pro dipeptidase activity:glutamine-fructose-6-phosphate transaminase (isomerizing) activity:membrane-associated guanylate kinase:guanylate kinase activity:ribonucleoside-diphosphate reductase activity:signal transducer activity:protein binding:ATP binding:sugar binding:amino sugar metabolic process:tricarboxylic acid cycle:electron transport:DNA replication:regulation of transcription, DNA-dependent:proteolysis:arginine biosynthetic process:creatine metabolic process:signal transduction:metabolic process:methyltransferase activity:peptidase activity:metalloexopeptidase activity:isoprenoid biosynthetic process:3'-5' exonuclease activity:mannose-1-phosphate guanylyltransferase (GDP) activity:electron carrier activity:biosynthetic process:methionine biosynthetic process:threonine biosynthetic process:lipopolysaccharide biosynthetic process:carbohydrate biosynthetic process:hydrolase activity:creatinase activity:peptidyl-histidine phosphorylation:carboxylic acid metabolic process:heat shock protein binding:cobalamin binding:2-alkenal reductase [NAD(P)] activity:protein dimerization activity:NADP binding:NAD binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Fructose and mannose metabolism:Fructose and mannose metabolism:Oxidative phosphorylation:Oxidative phosphorylation:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Pyruvate metabolism:Butanoate metabolism:Butanoate metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:DNA replication:DNA replication:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00089:TIGR00089:TIGR00255:TIGR00255:dhsB:dhsB:polc:polc:LeuA_rel:LeuA_rel:glmS:glmS:asd_B:asd_B:GMP_PMI:GMP_PMI:argC:argC:NrdJ_Z:NrdJ_Z:IV_pilin_GFxxxE:IV_pilin_GFxxxE:guanyl_kin:guanyl_kin:Unknown function:Conserved:Unknown function:General:Amino acid biosynthesis:Aspartate family:Glutamate family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Replication and Repair:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism:Hypothetical proteins:Amino acid biosynthesis:Cell envelope:Hypothetical proteins:Protein fate:DNA metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Energy metabolism:Central intermediary metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Glutamate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Aspartate family:General:Conserved:Energy Metabolism:Protein and peptide secretion and trafficking:Nucleotide Metabolism:DNA replication, recombination, and repair:2'-Deoxyribonucleotide metabolism:Amino Acid Metabolism:Nucleotide and nucleoside interconversions:TCA cycle:Amino sugars:Global:Genetic Information Processing:Metabolism:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Replication and Repair:Global:Metabolism:Central intermediary metabolism:Amino sugars:Energy metabolism:TCA cycle:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:2'-Deoxyribonucleotide metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking" 173 "Diaminopimelate decarboxylase:Diaminopimelate decarboxylase:Conserved domain frequently associated with peptide methionine sulfoxide reductase:Conserved domain frequently associated with peptide methionine sulfoxide reductase:Zn-dependent protease with chaperone function:Zn-dependent protease with chaperone function:Predicted hydrolase (HAD superfamily):Predicted hydrolase (HAD superfamily):Predicted membrane-bound metal-dependent hydrolases:Predicted membrane-bound metal-dependent hydrolases:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Amino acid transport and metabolism:Amino acid transport and metabolism:metalloendopeptidase activity:proteolysis:peptide-methionine-(S)-S-oxide reductase activity:metabolic process:hydrolase activity:carbon-carbon lyase activity:peptide-methionine (R)-S-oxide reductase activity:nor-spermidine biosynthetic process:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Arginine and proline metabolism:Arginine and proline metabolism:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:TIGR00357:TIGR00357:unchar_dom_1:unchar_dom_1:nspC:nspC:Cellular processes:Adaptations to atypical conditions:Cellular processes and signaling:Poorly characterized:Poorly characterized:Cellular processes and signaling:Cellular processes:Central intermediary metabolism:Adaptations to atypical conditions:Polyamine biosynthesis:Metabolism:Amino Acid Metabolism:Metabolism:Metabolism:Amino Acid Metabolism:Metabolism:Central intermediary metabolism:Polyamine biosynthesis" 174 "Energy production and conversion:Energy production and conversion:Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain:Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Pseudouridylate synthase:Pseudouridylate synthase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Geranylgeranyl pyrophosphate synthase:Geranylgeranyl pyrophosphate synthase:ABC-type sugar transport system, permease component:ABC-type sugar transport system, permease component:Glycosyltransferase:Glycosyltransferase:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type dipeptide transport system, periplasmic component:ABC-type dipeptide transport system, periplasmic component:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:Collagenase and related proteases:Collagenase and related proteases:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase:Ferredoxin:Ferredoxin:ABC-type sugar transport systems, permease components:ABC-type sugar transport systems, permease components:Glycosyltransferases, probably involved in cell wall biogenesis:Glycosyltransferases, probably involved in cell wall biogenesis:Type II secretory pathway, component PulF:Type II secretory pathway, component PulF:Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family:Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:UDP-glucose pyrophosphorylase:UDP-glucose pyrophosphorylase:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):pseudouridine synthesis:DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:UTP:glucose-1-phosphate uridylyltransferase activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity:phosphoribosylformylglycinamidine synthase activity:pseudouridylate synthase activity:signal transducer activity:transporter activity:binding:ATP binding:glucose metabolic process:glycolysis:electron transport:regulation of transcription, DNA-dependent:tRNA modification:proteolysis:fatty acid biosynthetic process:transport:chemotaxis:signal transduction:transcription factor binding:metabolic process:peptidase activity:isoprenoid biosynthetic process:protein transporter activity:4-amino-4-deoxychorismate lyase activity:4-phytase activity:electron carrier activity:biosynthetic process:lipid A biosynthetic process:pseudouridine synthase activity:peptide transporter activity:protein secretion by the type II secretion system:peptide transport:oxidoreductase activity:amino acid binding:transferase activity, transferring acyl groups:hydro-lyase activity:ATPase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:glyceraldehyde-3-phosphate metabolic process:carbohydrate binding:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity:metal ion binding:NAD binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Pentose and glucuronate interconversions:Galactose metabolism:Galactose metabolism:Fatty acid biosynthesis:Fatty acid biosynthesis:Fatty acid metabolism:Fatty acid metabolism:Purine metabolism:Purine metabolism:Tyrosine metabolism:Tyrosine metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Naphthalene degradation:Naphthalene degradation:Folate biosynthesis:Folate biosynthesis:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:GAPDH-I:GAPDH-I:oligo_HPY:oligo_HPY:fabZ:fabZ:lipid_A_lpxD:lipid_A_lpxD:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Metabolism:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Lipid Metabolism:Cellular processes and signaling:Cell envelope:Transport and binding proteins:Regulatory functions:Fatty acid and phospholipid metabolism:Energy metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Amino acids, peptides and amines:Small molecule interactions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Biosynthesis:Glycolysis/gluconeogenesis:Global:Lipid Metabolism:Cellular Processes:Environmental Information Processing:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:Transport and binding proteins:Amino acids, peptides and amines:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Metabolism" 175 "Energy production and conversion:Energy production and conversion:Uncharacterized conserved protein:Uncharacterized conserved protein:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Sulfate permease and related transporters (MFS superfamily):Sulfate permease and related transporters (MFS superfamily):Alanine dehydrogenase:Alanine dehydrogenase:Phosphate uptake regulator:Phosphate uptake regulator:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Cytochrome c553:Cytochrome c553:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Dissimilatory sulfite reductase (desulfoviridin), gamma subunit:Dissimilatory sulfite reductase (desulfoviridin), gamma subunit:Iron only hydrogenase large subunit, C-terminal domain:Iron only hydrogenase large subunit, C-terminal domain:Predicted ATP-dependent Lon-type protease:Predicted ATP-dependent Lon-type protease:Amino acid transport and metabolism:Amino acid transport and metabolism:alanine dehydrogenase activity:DNA binding:branched-chain-amino-acid transaminase activity:membrane-associated guanylate kinase:guanylate kinase activity:structural molecule activity:transporter activity:binding:iron ion binding:electron transport:alanine metabolic process:transport:NADH dehydrogenase (ubiquinone) activity:metabolic process:endopeptidase La activity:glutamate racemase activity:ferredoxin hydrogenase activity:electron carrier activity:nucleotide metabolic process:hydrolase activity:hydrogensulfite reductase activity:heme binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Taurine and hypotaurine metabolism:Taurine and hypotaurine metabolism:Methane metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Sulfur relay system:Sulfur relay system:General function prediction only:General function prediction only:Function unknown:Function unknown:TIGR00106:TIGR00106:alaDH:alaDH:phoU_full:phoU_full:FeFe_hydrog_A:FeFe_hydrog_A:TIGR02687:TIGR02687:TIGR02688:TIGR02688:Pal_lipo:Pal_lipo:dsrC_tusE_dsvC:dsrC_tusE_dsvC:Energy Metabolism:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Energy metabolism:Amino acids and amines:Transport and binding proteins:Anions:Hypothetical proteins:Conserved:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing:Unknown function:Hypothetical proteins:Transport and binding proteins:Energy metabolism:General:Conserved:Anions:Amino acids and amines:Global:Genetic Information Processing:Metabolism:Metabolism:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Global:Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism" 176 "Energy production and conversion:Energy production and conversion:Xaa-Pro aminopeptidase:Xaa-Pro aminopeptidase:Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase:Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase:Seryl-tRNA synthetase:Seryl-tRNA synthetase:Malic enzyme:Malic enzyme:Cytidylate kinase:Cytidylate kinase:Dihydrodipicolinate reductase:Dihydrodipicolinate reductase:Queuine/archaeosine tRNA-ribosyltransferase:Queuine/archaeosine tRNA-ribosyltransferase:Glycosyltransferase:Glycosyltransferase:Nucleoside-diphosphate-sugar epimerases:Nucleoside-diphosphate-sugar epimerases:Predicted acid phosphatase:Predicted acid phosphatase:Glycine cleavage system H protein (lipoate-binding):Glycine cleavage system H protein (lipoate-binding):Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:ABC-type Fe3+-siderophore transport system, permease component:ABC-type Fe3+-siderophore transport system, permease component:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:Transcription-repair coupling factor (superfamily II helicase):Transcription-repair coupling factor (superfamily II helicase):Coenzyme F390 synthetase:Coenzyme F390 synthetase:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Sialic acid synthase:Sialic acid synthase:Precorrin-2 methylase:Precorrin-2 methylase:Predicted methyltransferase:Predicted methyltransferase:Iron only hydrogenase large subunit, C-terminal domain:Iron only hydrogenase large subunit, C-terminal domain:Cobalamin biosynthesis protein CbiK, Co2+ chelatase:Cobalamin biosynthesis protein CbiK, Co2+ chelatase:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Membrane carboxypeptidase/penicillin-binding protein:Membrane carboxypeptidase/penicillin-binding protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:recombinase activity:two-component sensor activity:two-component signal transduction system (phosphorelay):rhodopsin-like receptor activity:nucleic acid binding:damaged DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:acid phosphatase activity:cytidylate kinase activity:X-Pro dipeptidase activity:glycine cleavage system:glycine dehydrogenase (decarboxylating) activity:malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity:phosphoribosylaminoimidazole carboxylase activity:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity:shikimate kinase activity:serine-tRNA ligase activity:transporter activity:iron ion binding:ATP binding:carbohydrate metabolic process:polysaccharide metabolic process:electron transport:nucleobase-containing compound metabolic process:purine nucleotide biosynthetic process:'de novo' IMP biosynthetic process:DNA repair:DNA recombination:regulation of transcription, DNA-dependent:tRNA modification:seryl-tRNA aminoacylation:proteolysis:glycine catabolic process:creatine metabolic process:transport:response to stress:G-protein coupled receptor signaling pathway:ATP-dependent helicase activity:NADH dehydrogenase (ubiquinone) activity:metabolic process:peptidase activity:metalloexopeptidase activity:5'-nucleotidase activity:3'-nucleotidase activity:queuine tRNA-ribosyltransferase activity:queuosine biosynthetic process:penicillin binding:ADP-glyceromanno-heptose 6-epimerase activity:dihydrodipicolinate reductase activity:ferredoxin hydrogenase activity:mannose-1-phosphate guanylyltransferase (GDP) activity:electron carrier activity:biosynthetic process:lysine biosynthetic process via diaminopimelate:cyclic nucleotide biosynthetic process:cobalamin biosynthetic process:peptidoglycan biosynthetic process:protein transport:iron-chelate-transporting ATPase activity:carbohydrate biosynthetic process:oxidoreductase activity:transferase activity, transferring pentosyl groups:phosphorus-oxygen lyase activity:sirohydrochlorin cobaltochelatase activity:creatinase activity:nucleoside-triphosphatase activity:IMP-GMP specific 5'-nucleotidase activity:precorrin-2 C20-methyltransferase activity:intracellular signal transduction:cobalt-factor II C20-methyltransferase activity:cellular metabolic process:nutrient reservoir activity:response to antibiotic:N-acylneuraminate-9-phosphate synthase activity:phenylacetate-CoA ligase activity:N-acetylneuraminate synthase activity:NADP binding:NAD binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Lysine biosynthesis:Lysine biosynthesis:Phenylalanine metabolism:Phenylalanine metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Methane metabolism:Methane metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Nucleotide excision repair:Nucleotide excision repair:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:cmk:cmk:dapB:dapB:purC:purC:surE:surE:sensory_box:sensory_box:serS:serS:Q_tRNA_tgt:Q_tRNA_tgt:gcvH:gcvH:mfd:mfd:purE:purE:cobI_cbiL:cobI_cbiL:PBP_1a_fam:PBP_1a_fam:heptose_epim:heptose_epim:FeFe_hydrog_A:FeFe_hydrog_A:Translation:Replication and Repair:Membrane Transport:Metabolism:Energy metabolism:Amino acids and amines:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Purine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Cellular processes:Adaptations to atypical conditions:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Nucleotide Metabolism:Cell envelope:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino acid biosynthesis:Cellular processes:Energy Metabolism:Carbohydrate Metabolism:Protein synthesis:DNA metabolism:Regulatory functions:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Energy metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Biosynthesis and degradation of murein sacculus and peptidoglycan:Heme, porphyrin, and cobalamin:Aspartate family:Adaptations to atypical conditions:tRNA and rRNA base modification:tRNA aminoacylation:DNA replication, recombination, and repair:Small molecule interactions:Purine ribonucleotide biosynthesis:Nucleotide and nucleoside interconversions:Amino acids and amines:Global:Environmental Information Processing:Genetic Information Processing:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Energy Metabolism:Carbohydrate Metabolism:Metabolism of Cofactors and Vitamins:Metabolism:Poorly characterized:Genetic Information Processing:Translation:Metabolism:Replication and Repair:Cellular processes and signaling:Environmental Information Processing:Membrane Transport:Information storage and processing:Global:Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins" 177 "Methionine aminopeptidase:Methionine aminopeptidase:Ribosomal protein L3:Ribosomal protein L3:Ribosomal protein L22:Ribosomal protein L22:Ribosomal protein S3:Ribosomal protein S3:Ribosomal protein S5:Ribosomal protein S5:Ribosomal protein S13:Ribosomal protein S13:Ribosomal protein S11:Ribosomal protein S11:Ribosomal protein L16/L10E:Ribosomal protein L16/L10E:DNA-directed RNA polymerase, alpha subunit/40 kD subunit:DNA-directed RNA polymerase, alpha subunit/40 kD subunit:Ribosomal protein L17:Ribosomal protein L17:Ribosomal protein S4 and related proteins:Ribosomal protein S4 and related proteins:DNA binding:RNA binding:structural constituent of ribosome:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:methionyl aminopeptidase activity:transcription, DNA-dependent:translation:protein modification process:proteolysis:rRNA binding:protein dimerization activity:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Metabolic pathways:Metabolic pathways:Ribosome:Ribosome:RNA polymerase:RNA polymerase:L17:L17:met_pdase_I:met_pdase_I:rpsC_bact:rpsC_bact:rpsD_bact:rpsD_bact:rpsE_bact:rpsE_bact:rpmJ_bact:rpmJ_bact:rplV_bact:rplV_bact:rplP_bact:rplP_bact:rpoA:rpoA:L3_bact:L3_bact:bact_S13:bact_S13:bact_S11:bact_S11:Global:Translation:Transcription:Genetic Information Processing:Nucleotide Metabolism:Metabolism:Information storage and processing:Nucleotide Metabolism:Transcription:DNA-dependent RNA polymerase:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein modification and repair:Information storage and processing:Protein fate:Protein synthesis:Transcription:Protein modification and repair:Ribosomal proteins: synthesis and modification:DNA-dependent RNA polymerase:Global:Genetic Information Processing:Metabolism:Metabolism:Translation:Transcription:Metabolism" 178 "Energy production and conversion:Energy production and conversion:Putative intracellular protease/amidase:Putative intracellular protease/amidase:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Molybdopterin-guanine dinucleotide biosynthesis protein:Molybdopterin-guanine dinucleotide biosynthesis protein:HD-GYP domain:HD-GYP domain:Outer membrane lipoprotein-sorting protein:Outer membrane lipoprotein-sorting protein:Cytochrome c553:Cytochrome c553:Tfp pilus assembly protein PilF:Tfp pilus assembly protein PilF:Amino acid transport and metabolism:Amino acid transport and metabolism:nucleotide binding:catalytic activity:transporter activity:binding:iron ion binding:ATP binding:GTP binding:electron transport:Mo-molybdopterin cofactor biosynthetic process:transport:electron carrier activity:protein transport:hydrolase activity, acting on glycosyl bonds:nucleoside-triphosphatase activity:heme binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:HDIG:HDIG:lolA:lolA:PfpI:PfpI:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Cellular processes and signaling:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking:Cellular processes and signaling:Protein fate:Protein fate:Membrane Transport:Environmental Information Processing:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking:Environmental Information Processing:Membrane Transport:Poorly characterized:Metabolism:Metabolism" 179 "Energy production and conversion:Energy production and conversion:Ribosomal protein S15P/S13E:Ribosomal protein S15P/S13E:Folylpolyglutamate synthase:Folylpolyglutamate synthase:Carbonic anhydrase:Carbonic anhydrase:Transcriptional regulator:Transcriptional regulator:Membrane proteins related to metalloendopeptidases:Membrane proteins related to metalloendopeptidases:FOG: CheY-like receiver:FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:ABC-type phosphate transport system, ATPase component:ABC-type phosphate transport system, ATPase component:6Fe-6S prismane cluster-containing protein:6Fe-6S prismane cluster-containing protein:Predicted transcriptional regulator:Predicted transcriptional regulator:N-terminal domain of molybdenum-binding protein:N-terminal domain of molybdenum-binding protein:ABC-type proline/glycine betaine transport systems, periplasmic components:ABC-type proline/glycine betaine transport systems, periplasmic components:Predicted membrane protein:Predicted membrane protein:Uncharacterized phage-encoded protein:Uncharacterized phage-encoded protein:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:sequence-specific DNA binding transcription factor activity:structural constituent of ribosome:carbonate dehydratase activity:metalloendopeptidase activity:tetrahydrofolylpolyglutamate synthase activity:transporter activity:inorganic phosphate transmembrane transporter activity:binding:ATP binding:electron transport:regulation of transcription, DNA-dependent:translation:proteolysis:transport:phosphate ion transport:chemotaxis:metabolic process:zinc ion binding:dihydrofolate synthase activity:folic acid-containing compound biosynthetic process:phosphate ion transmembrane-transporting ATPase activity:carbon utilization:proton transport:nickel ion binding:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances:nucleoside-triphosphatase activity:carbon-monoxide dehydrogenase (acceptor) activity:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Nitrotoluene degradation:Nitrotoluene degradation:Methane metabolism:Methane metabolism:Folate biosynthesis:Folate biosynthesis:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Ribosome:Ribosome:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:rrf2_super:rrf2_super:S15_bact:S15_bact:3a0107s01c2:3a0107s01c2:folC:folC:CO_DH_cata:CO_DH_cata:phage_pRha:phage_pRha:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Energy Metabolism:Environmental Information Processing:Genetic Information Processing:Cellular Processes:Global:Ribosomal proteins: synthesis and modification:Anions:Prophage functions:General:Folic acid:Protein synthesis:Transport and binding proteins:Mobile and extrachromosomal element functions:Unknown function:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Protein synthesis:Ribosomal proteins: synthesis and modification:Transport and binding proteins:Anions:Mobile and extrachromosomal element functions:Prophage functions:Unknown function" 180 "Energy production and conversion:Energy production and conversion:Glutamyl- and glutaminyl-tRNA synthetases:Glutamyl- and glutaminyl-tRNA synthetases:Adenylosuccinate lyase:Adenylosuccinate lyase:Isoleucyl-tRNA synthetase:Isoleucyl-tRNA synthetase:Imidazoleglycerol-phosphate dehydratase:Imidazoleglycerol-phosphate dehydratase:Tryptophanyl-tRNA synthetase:Tryptophanyl-tRNA synthetase:Predicted phosphatases:Predicted phosphatases:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain:Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Predicted SAM-dependent methyltransferases:Predicted SAM-dependent methyltransferases:Uncharacterized membrane protein, required for colicin V production:Uncharacterized membrane protein, required for colicin V production:Alcohol dehydrogenase, class IV:Alcohol dehydrogenase, class IV:Uncharacterized conserved protein:Uncharacterized conserved protein:Transcriptional regulators:Transcriptional regulators:Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog:Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog:Uncharacterized conserved protein:Uncharacterized conserved protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:DNA polymerase III, gamma/tau subunits:DNA polymerase III, gamma/tau subunits:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:histidine biosynthetic process:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:catalytic activity:DNA-directed DNA polymerase activity:GTP cyclohydrolase I activity:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:glycine cleavage system:glycine dehydrogenase (decarboxylating) activity:imidazoleglycerol-phosphate dehydratase activity:peroxidase activity:glutamine-tRNA ligase activity:isoleucine-tRNA ligase activity:tryptophan-tRNA ligase activity:urate oxidase activity:binding:ATP binding:electron transport:purine base metabolic process:DNA replication:DNA repair:DNA recombination:regulation of transcription, DNA-dependent:glutamyl-tRNA aminoacylation:glutaminyl-tRNA aminoacylation:isoleucyl-tRNA aminoacylation:tryptophanyl-tRNA aminoacylation:proteolysis:glycine metabolic process:response to oxidative stress:transcription factor binding:metabolic process:methyltransferase activity:metallopeptidase activity:zinc ion binding:succinyl-diaminopimelate desuccinylase activity:lipopolysaccharide biosynthetic process:purine ribonucleotide biosynthetic process:oligosaccharide biosynthetic process:four-way junction helicase activity:toxin biosynthetic process:nodulation:nucleoside-triphosphatase activity:heme binding:pyridoxal phosphate binding:sequence-specific DNA binding:metal ion binding:protein dimerization activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Histidine metabolism:Histidine metabolism:Tryptophan metabolism:Tryptophan metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:DNA replication:DNA replication:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:trpS:trpS:ileS:ileS:TIGR00423:TIGR00423:glnS:glnS:TIGR00702:TIGR00702:purB:purB:dnaX_nterm:dnaX_nterm:Purine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Hypothetical proteins:Conserved:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Replication and Repair:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Translation:Amino Acid Metabolism:Nucleotide Metabolism:Protein synthesis:Global:Replication and Repair:Translation:Genetic Information Processing:Amino Acid Metabolism:Nucleotide Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Genetic Information Processing:Global:Purine ribonucleotide biosynthesis:DNA replication, recombination, and repair:tRNA aminoacylation:Conserved:Purines, pyrimidines, nucleosides, and nucleotides:Hypothetical proteins:DNA metabolism" 181 "Energy production and conversion:Energy production and conversion:Folate-dependent phosphoribosylglycinamide formyltransferase PurN:Folate-dependent phosphoribosylglycinamide formyltransferase PurN:Branched-chain amino acid ABC-type transport system, permease components:Branched-chain amino acid ABC-type transport system, permease components:Periplasmic serine proteases (ClpP class):Periplasmic serine proteases (ClpP class):Permeases of the drug/metabolite transporter (DMT) superfamily:Permeases of the drug/metabolite transporter (DMT) superfamily:Uncharacterized membrane protein, putative virulence factor:Uncharacterized membrane protein, putative virulence factor:Predicted permeases:Predicted permeases:ABC-type metal ion transport system, periplasmic component/surface adhesin:ABC-type metal ion transport system, periplasmic component/surface adhesin:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:TRAP-type C4-dicarboxylate transport system, large permease component:TRAP-type C4-dicarboxylate transport system, large permease component:ABC-type Na+ efflux pump, permease component:ABC-type Na+ efflux pump, permease component:Na+/H+ antiporter:Na+/H+ antiporter:Membrane protein involved in the export of O-antigen and teichoic acid:Membrane protein involved in the export of O-antigen and teichoic acid:ABC-type phosphate/phosphonate transport system, periplasmic component:ABC-type phosphate/phosphonate transport system, periplasmic component:Predicted membrane protein:Predicted membrane protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:polysaccharide biosynthetic process:DNA binding:sequence-specific DNA binding transcription factor activity:dihydrolipoyl dehydrogenase activity:phosphoribosylglycinamide formyltransferase activity:transporter activity:binding:ATP binding:electron transport:'de novo' IMP biosynthetic process:regulation of transcription, DNA-dependent:translation:proteolysis:transport:sodium ion transport:regulation of pH:peptidase activity:pathogenesis:sodium:hydrogen antiporter activity:phosphonate transmembrane transporter activity:phosphonate transport:mercury (II) reductase activity:ATPase activity, coupled to transmembrane movement of substances:sequence-specific DNA binding:cell redox homeostasis:flavin adenine dinucleotide binding:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:One carbon pool by folate:One carbon pool by folate:Methane metabolism:Methane metabolism:Folate biosynthesis:Folate biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Two-component system:Two-component system:General function prediction only:General function prediction only:Function unknown:Function unknown:PurN:PurN:dctM:dctM:antiport_nhaC:antiport_nhaC:mviN:mviN:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Transport and binding proteins:Membrane Transport:Signal Transduction:Metabolism:Metabolism:Environmental Information Processing:Global:Purine ribonucleotide biosynthesis:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:General:Purines, pyrimidines, nucleosides, and nucleotides:Transport and binding proteins:Unknown function:Glycan Biosynthesis and Metabolism:Nucleotide Metabolism:Energy Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Metabolism of Cofactors and Vitamins:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Unknown function:General:Cellular processes and signaling:Metabolism:Poorly characterized" 182 "DnaK suppressor protein:DnaK suppressor protein:Uncharacterized ATPase, putative transposase:Uncharacterized ATPase, putative transposase:TRAP-type C4-dicarboxylate transport system, small permease component:TRAP-type C4-dicarboxylate transport system, small permease component:Mu-like prophage I protein:Mu-like prophage I protein:Mu-like prophage protein gp37:Mu-like prophage protein gp37:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:iron ion binding:zinc ion binding:DNA integration:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:Metabolism:Cellular processes and signaling:Poorly characterized:Poorly characterized:Cellular processes and signaling:Metabolism" 183 "Predicted xylanase/chitin deacetylase:Predicted xylanase/chitin deacetylase:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:Uncharacterized ATPase, putative transposase:Uncharacterized ATPase, putative transposase:Predicted ATPase:Predicted ATPase:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:nucleotide binding:nucleic acid binding:DNA binding:carbohydrate metabolic process:DNA replication:DNA modification:zinc ion binding:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:nucleoside-triphosphatase activity:Replication, recombination and repair:Replication, recombination and repair:General function prediction only:General function prediction only:primase_Cterm:primase_Cterm:psiM2_ORF9:psiM2_ORF9:Poorly characterized:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Metabolism:Poorly characterized:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Metabolism" 184 "Energy production and conversion:Energy production and conversion:Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:Membrane proteins related to metalloendopeptidases:Membrane proteins related to metalloendopeptidases:Fe-S oxidoreductase:Fe-S oxidoreductase:Flagellar biosynthesis/type III secretory pathway ATPase:Flagellar biosynthesis/type III secretory pathway ATPase:Flagellar biosynthesis/type III secretory pathway protein:Flagellar biosynthesis/type III secretory pathway protein:Flagellar biosynthesis pathway, component FliP:Flagellar biosynthesis pathway, component FliP:Flagellin and related hook-associated proteins:Flagellin and related hook-associated proteins:Flagellar capping protein:Flagellar capping protein:Flagellin-specific chaperone FliS:Flagellin-specific chaperone FliS:Flagellar motor switch protein:Flagellar motor switch protein:Carbon storage regulator (could also regulate swarming and quorum sensing):Carbon storage regulator (could also regulate swarming and quorum sensing):Flagellar basal body rod protein:Flagellar basal body rod protein:Flagellar basal body-associated protein:Flagellar basal body-associated protein:Flagellar hook-basal body protein:Flagellar hook-basal body protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Flagellar basal-body P-ring protein:Flagellar basal-body P-ring protein:Flagellar biosynthesis/type III secretory pathway lipoprotein:Flagellar biosynthesis/type III secretory pathway lipoprotein:Flagellar motor switch/type III secretory pathway protein:Flagellar motor switch/type III secretory pathway protein:Flagellar basal body L-ring protein:Flagellar basal body L-ring protein:Flagellar basal body rod protein:Flagellar basal body rod protein:ciliary or flagellar motility:RNA binding:motor activity:catalytic activity:hydrogen-transporting two-sector ATPase activity:metalloendopeptidase activity:triglyceride lipase activity:structural molecule activity:transporter activity:binding:ATP binding:regulation of carbohydrate metabolic process:proteolysis:transport:cation transport:chemotaxis:cell adhesion:metabolic process:cation transmembrane transporter activity:flagellum assembly:protein secretion:protein transport:ATP synthesis coupled proton transport:mRNA metabolic process:cobalamin binding:flagellum organization:metal ion binding:hydrogen ion transporting ATP synthase activity, rotational mechanism:proton-transporting ATPase activity, rotational mechanism:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity:iron-sulfur cluster binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:csrA:csrA:fliE:fliE:fliF:fliF:fliG:fliG:fliS:fliS:fliI_yscN:fliI_yscN:fliP:fliP:FlgC:FlgC:flagell_FliJ:flagell_FliJ:fliN:fliN:flgG_G_neg:flgG_G_neg:flgF:flgF:flgK_ends:flgK_ends:flagell_flgL:flagell_flgL:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Energy metabolism:Cellular processes and signaling:Chemotaxis and motility:RNA interactions:Poorly characterized:Metabolism:ATP-proton motive force interconversion:Cellular Processes:Environmental Information Processing:Cell Motility:Cellular processes and signaling:Chemotaxis and motility:Cellular processes:RNA interactions:Regulatory functions:ATP-proton motive force interconversion:Energy metabolism:Signal Transduction:Cell Motility:Cellular Processes:Cellular processes:Signal Transduction:Environmental Information Processing:Poorly characterized:Metabolism:Regulatory functions" 185 "Energy production and conversion:Energy production and conversion:Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase):Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase):tRNA-dihydrouridine synthase:tRNA-dihydrouridine synthase:N-methylhydantoinase A/acetone carboxylase, beta subunit:N-methylhydantoinase A/acetone carboxylase, beta subunit:Predicted hydrolase of the alpha/beta-hydrolase fold:Predicted hydrolase of the alpha/beta-hydrolase fold:Aspartate/tyrosine/aromatic aminotransferase:Aspartate/tyrosine/aromatic aminotransferase:Predicted phosphatases:Predicted phosphatases:Penicillin tolerance protein:Penicillin tolerance protein:Cation/multidrug efflux pump:Cation/multidrug efflux pump:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Predicted glycosyltransferases:Predicted glycosyltransferases:Flagellar motor protein:Flagellar motor protein:Predicted flavoproteins:Predicted flavoproteins:2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase:2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase:Putative homoserine kinase type II (protein kinase fold):Putative homoserine kinase type II (protein kinase fold):Flagellar biogenesis protein:Flagellar biogenesis protein:Predicted spermidine synthase with an N-terminal membrane domain:Predicted spermidine synthase with an N-terminal membrane domain:Urea transporter:Urea transporter:Signal transduction histidine kinase:Signal transduction histidine kinase:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):catalytic activity:L-aspartate:2-oxoglutarate aminotransferase activity:ATP binding:electron transport:tRNA processing:metabolic process:methyltransferase activity:L-aspartate oxidase activity:phosphoglycolate phosphatase activity:biosynthetic process:purine base biosynthetic process:urea transmembrane transporter activity:urea transport:oxidoreductase activity:hydroxymethyl-, formyl- and related transferase activity:transferase activity, transferring nitrogenous groups:hydrolase activity:isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway:pyridoxal phosphate binding:flagellum organization:protein dimerization activity:flavin adenine dinucleotide binding:iron-sulfur cluster binding:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Purine metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:One carbon pool by folate:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:ispH_lytB:ispH_lytB:TIGR00275:TIGR00275:purT:purT:HAD-SF-IA-v3:HAD-SF-IA-v3:FliO_TIGR:FliO_TIGR:SAM_YgiQ:SAM_YgiQ:Defense mechanisms:Defense mechanisms:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Other:Enzymes of unknown specificity:Purine ribonucleotide biosynthesis:Global:Cellular Processes:Metabolism:Metabolism:Cell Motility:Carbohydrate Metabolism:Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Unknown function:Biosynthesis of cofactors, prosthetic groups, and carriers:Cellular Processes:Metabolism of Terpenoids and Polyketides:Cell Motility:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Other" 186 "Energy production and conversion:Energy production and conversion:Phenylalanyl-tRNA synthetase alpha subunit:Phenylalanyl-tRNA synthetase alpha subunit:Pentose-5-phosphate-3-epimerase:Pentose-5-phosphate-3-epimerase:Ribosomal protein S2:Ribosomal protein S2:Phenylalanyl-tRNA synthetase beta subunit:Phenylalanyl-tRNA synthetase beta subunit:Ribosomal protein S9:Ribosomal protein S9:Fructose/tagatose bisphosphate aldolase:Fructose/tagatose bisphosphate aldolase:Fe-S oxidoreductase:Fe-S oxidoreductase:Translation elongation factor Ts:Translation elongation factor Ts:Ribosomal protein L33:Ribosomal protein L33:Ribosomal protein S20:Ribosomal protein S20:Translation initiation factor 3 (IF-3):Translation initiation factor 3 (IF-3):Ribosomal protein L35:Ribosomal protein L35:Ribosomal protein L20:Ribosomal protein L20:Replicative DNA helicase:Replicative DNA helicase:Ribosomal protein L9:Ribosomal protein L9:ABC-type transport system involved in Fe-S cluster assembly, ATPase component:ABC-type transport system involved in Fe-S cluster assembly, ATPase component:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:ABC-type transport system involved in Fe-S cluster assembly, permease component:ABC-type transport system involved in Fe-S cluster assembly, permease component:Periplasmic component of the Tol biopolymer transport system:Periplasmic component of the Tol biopolymer transport system:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:tRNA binding:magnesium ion binding:DNA binding:DNA helicase activity:sequence-specific DNA binding transcription factor activity:RNA binding:structural constituent of ribosome:translation initiation factor activity:translation elongation factor activity:GTPase activity:fructose-bisphosphate aldolase activity:ribulose-phosphate 3-epimerase activity:phenylalanine-tRNA ligase activity:binding:protein binding:ATP binding:carbohydrate metabolic process:glycolysis:pentose-phosphate shunt:electron transport:DNA replication:regulation of transcription, DNA-dependent:translation:translational initiation:translational elongation:phenylalanyl-tRNA aminoacylation:transport:tRNA processing:zinc ion binding:protein-synthesizing GTPase activity:tagatose-bisphosphate aldolase activity:electron carrier activity:protein transport:iron-sulfur cluster assembly:oxidoreductase activity:ATPase activity:fructose 1,6-bisphosphate metabolic process:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Pentose and glucuronate interconversions:Pentose and glucuronate interconversions:Fructose and mannose metabolism:Fructose and mannose metabolism:Methane metabolism:Methane metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Ribosome:Ribosome:DNA replication:DNA replication:Signal transduction mechanisms:Signal transduction mechanisms:rpmI_bact:rpmI_bact:S20:S20:tsf:tsf:L9:L9:cbbA:cbbA:infC:infC:pheS:pheS:pheT_bact:pheT_bact:DnaB:DnaB:rpsB_bact:rpsB_bact:rpmG_bact:rpmG_bact:rplT_bact:rplT_bact:rpe:rpe:tol_pal_ybgF:tol_pal_ybgF:propeller_TolB:propeller_TolB:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:DNA replication, recombination, and repair:Glycolysis/gluconeogenesis:Pentose phosphate pathway:DNA replication, recombination, and repair:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Translation factors:Pathogenesis:Energy metabolism:DNA metabolism:Protein synthesis:Cellular processes:Genetic Information Processing:Metabolism:Metabolism:Replication and Repair:Translation:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Carbohydrate Metabolism:Energy Metabolism:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Pentose phosphate pathway:DNA metabolism:Global:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Translation factors:Cellular processes:Pathogenesis:Information storage and processing:Cellular processes and signaling:Metabolism" 187 "1-acyl-sn-glycerol-3-phosphate acyltransferase:1-acyl-sn-glycerol-3-phosphate acyltransferase:tRNA delta(2)-isopentenylpyrophosphate transferase:tRNA delta(2)-isopentenylpyrophosphate transferase:Lipid A disaccharide synthetase:Lipid A disaccharide synthetase:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:FKBP-type peptidyl-prolyl cis-trans isomerases 2:FKBP-type peptidyl-prolyl cis-trans isomerases 2:Multiple antibiotic transporter:Multiple antibiotic transporter:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:HD-GYP domain:HD-GYP domain:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted periplasmic protein:Predicted periplasmic protein:Predicted transcriptional regulator:Predicted transcriptional regulator:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:peptidyl-prolyl cis-trans isomerase activity:1-acylglycerol-3-phosphate O-acyltransferase activity:dimethylallyltranstransferase activity:cyclophilin:signal transducer activity:transporter activity:ATP binding:regulation of transcription, DNA-dependent:tRNA modification:protein folding:transport:signal transduction:tRNA processing:transcription factor binding:metabolic process:zinc ion binding:lipid-A-disaccharide synthase activity:biosynthetic process:lipid A biosynthetic process:pathogenesis:transferase activity, transferring acyl groups other than amino-acyl groups:nucleoside-triphosphatase activity:FK506-sensitive peptidyl-prolyl cis-trans isomerase:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:regulation of protein secretion:tRNA dimethylallyltransferase activity:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Glycerolipid metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:miaA:miaA:lpxB:lpxB:sensory_box:sensory_box:TIGR00427:TIGR00427:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Global:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA and rRNA base modification:Unknown function:General:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Glycan Biosynthesis and Metabolism:Lipid Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Cell envelope:Unknown function:Protein synthesis:Regulatory functions:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:General:tRNA and rRNA base modification:Small molecule interactions:Global:Metabolism:Metabolism:Glycan Biosynthesis and Metabolism:Lipid Metabolism" 188 "Energy production and conversion:Energy production and conversion:Fructose-1,6-bisphosphatase:Fructose-1,6-bisphosphatase:Aspartyl-tRNA synthetase:Aspartyl-tRNA synthetase:Ribosomal protein S18:Ribosomal protein S18:Fe-S oxidoreductase:Fe-S oxidoreductase:Ribosomal protein L33:Ribosomal protein L33:Replicative DNA helicase:Replicative DNA helicase:tRNA-(guanine-N1)-methyltransferase:tRNA-(guanine-N1)-methyltransferase:Ribosomal protein L9:Ribosomal protein L9:ABC-type transport system involved in Fe-S cluster assembly, ATPase component:ABC-type transport system involved in Fe-S cluster assembly, ATPase component:Signal recognition particle GTPase:Signal recognition particle GTPase:Exoribonuclease R:Exoribonuclease R:ATPase involved in DNA replication initiation:ATPase involved in DNA replication initiation:tRNA nucleotidyltransferase/poly(A) polymerase:tRNA nucleotidyltransferase/poly(A) polymerase:ABC-type transport system involved in Fe-S cluster assembly, permease component:ABC-type transport system involved in Fe-S cluster assembly, permease component:Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis):Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis):Phosphomannomutase:Phosphomannomutase:ABC-type (unclassified) transport system, ATPase component:ABC-type (unclassified) transport system, ATPase component:Zn-ribbon protein, possibly nucleic acid-binding:Zn-ribbon protein, possibly nucleic acid-binding:Low specificity phosphatase (HAD superfamily):Low specificity phosphatase (HAD superfamily):3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase:3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:recombinase activity:magnesium ion binding:nucleic acid binding:DNA binding:DNA helicase activity:DNA replication origin binding:RNA binding:structural constituent of ribosome:GTPase activity:nuclease activity:polynucleotide adenylyltransferase activity:aspartate-tRNA ligase activity:protein binding:ATP binding:GTP binding:carbohydrate metabolic process:gluconeogenesis:electron transport:DNA replication:DNA-dependent DNA replication initiation:regulation of DNA replication:DNA repair:DNA recombination:tRNA modification:translation:aspartyl-tRNA aminoacylation:SRP-dependent cotranslational protein targeting to membrane:transport:tRNA processing:7S RNA binding:signal-recognition-particle GTPase activity:3-deoxy-8-phosphooctulonate synthase activity:exoribonuclease II activity:phosphoglucosamine mutase activity:tRNA (guanine-N1-)-methyltransferase activity:electron carrier activity:biosynthetic process:lipopolysaccharide biosynthetic process:iron-sulfur cluster assembly:oxidoreductase activity:ATPase activity:nucleoside-triphosphatase activity:3-deoxy-manno-octulosonate-8-phosphatase activity:fructose 1,6-bisphosphate 1-phosphatase activity:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Fructose and mannose metabolism:Fructose and mannose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Methane metabolism:Methane metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Ribosome:Ribosome:RNA degradation:RNA degradation:DNA replication:DNA replication:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:trmD:trmD:L9:L9:S18:S18:RNAse_H_YqgF:RNAse_H_YqgF:aspS_bact:aspS_bact:DnaB:DnaB:ffh:ffh:rpmG_bact:rpmG_bact:KDO8P_synth:KDO8P_synth:glmM:glmM:YrbI-phosphatas:YrbI-phosphatas:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Signal Transduction:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:Amino sugars:DNA replication, recombination, and repair:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Protein and peptide secretion and trafficking:General:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Central intermediary metabolism:DNA metabolism:Protein synthesis:Protein fate:Unknown function:Cell envelope:Membrane Transport:Replication and Repair:Folding Sorting and Degradation:Translation:Glycan Biosynthesis and Metabolism:Energy Metabolism:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Central intermediary metabolism:Amino sugars:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Unknown function:General:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing" 189 "Energy production and conversion:Energy production and conversion:Fe-S oxidoreductase:Fe-S oxidoreductase:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:FOG: CheY-like receiver:FOG: CheY-like receiver:Predicted transcriptional regulator:Predicted transcriptional regulator:Carbon starvation protein, predicted membrane protein:Carbon starvation protein, predicted membrane protein:Uncharacterized protein involved in methicillin resistance:Uncharacterized protein involved in methicillin resistance:Putative regulator of cell autolysis:Putative regulator of cell autolysis:Response regulator of the LytR/AlgR family:Response regulator of the LytR/AlgR family:Polysulphide reductase:Polysulphide reductase:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):iron ion binding:ATP binding:electron transport:regulation of transcription, DNA-dependent:cellular cell wall organization:formate dehydrogenase (NAD+) activity:electron carrier activity:peptidoglycan biosynthetic process:cellular response to starvation:peptidyl-histidine phosphorylation:heme binding:iron-sulfur cluster binding:Transcription:Transcription:Two-component system:Two-component system:Signal transduction mechanisms:Signal transduction mechanisms:rrf2_super:rrf2_super:Defense mechanisms:Defense mechanisms:Metabolism:General:Unknown function:Signal Transduction:Unknown function:Information storage and processing:Environmental Information Processing:Signal Transduction:Environmental Information Processing:Metabolism:Cellular processes and signaling:Information storage and processing:General:Cellular processes and signaling" 190 "Energy production and conversion:Energy production and conversion:Glycosyltransferase:Glycosyltransferase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:UDP-glucose 4-epimerase:UDP-glucose 4-epimerase:Predicted membrane protein involved in D-alanine export:Predicted membrane protein involved in D-alanine export:Transposase and inactivated derivatives:Transposase and inactivated derivatives:Predicted helicase:Predicted helicase:DNA binding:UDP-glucose 4-epimerase activity:helicase activity:endonuclease activity:transposase activity:glutamate-tRNA ligase activity:ATP binding:carbohydrate metabolic process:electron transport:transposition, DNA-mediated:methyltransferase activity:biosynthetic process:DNA integration:hydrolase activity:methylation:cellular metabolic process:2-oxoglutarate synthase activity:coenzyme binding:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:PEP_exosort:PEP_exosort:Cell envelope:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Surface structures:Global:Metabolism:Metabolism:Carbohydrate Metabolism:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Global:Metabolism:Cell envelope" 191 "Energy production and conversion:Energy production and conversion:Fe2+ transport system protein B:Fe2+ transport system protein B:Predicted Zn-dependent peptidases:Predicted Zn-dependent peptidases:Flavodoxins:Flavodoxins:Periplasmic protein TonB, links inner and outer membranes:Periplasmic protein TonB, links inner and outer membranes:Biopolymer transport proteins:Biopolymer transport proteins:Biopolymer transport protein:Biopolymer transport protein:ABC-type multidrug transport system, ATPase component:ABC-type multidrug transport system, ATPase component:Fe2+ transport system protein A:Fe2+ transport system protein A:FOG: GGDEF domain:FOG: GGDEF domain:AraC-type DNA-binding domain-containing proteins:AraC-type DNA-binding domain-containing proteins:Cation transport ATPase:Cation transport ATPase:DNA gyrase inhibitor:DNA gyrase inhibitor:nucleoside binding:DNA binding:sequence-specific DNA binding transcription factor activity:copper-exporting ATPase activity:metalloendopeptidase activity:receptor activity:transporter activity:iron ion transmembrane transporter activity:iron ion binding:ATP binding:GTP binding:electron transport:regulation of transcription, DNA-dependent:proteolysis:transport:iron ion transport:microtubule-based process:metabolic process:zinc ion binding:protein transporter activity:electron carrier activity:cyclic nucleotide biosynthetic process:FMN binding:protein transport:ferrous iron transmembrane transporter activity:ferrous iron transport:phosphorus-oxygen lyase activity:ATPase activity:metal ion transport:intracellular signal transduction:sequence-specific DNA binding:metal ion binding:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:GGDEF:GGDEF:feoB:feoB:tonB_Cterm:tonB_Cterm:ATPase-IB_hvy:ATPase-IB_hvy:flav_short:flav_short:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Information storage and processing:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Signal transduction:Cations and iron carrying compounds:Poorly characterized:Signal transduction:Transport and binding proteins:Energy metabolism:Other:Cations and iron carrying compounds:Electron transport:Transport and binding proteins:Electron transport:Energy metabolism:Cellular processes and signaling" 192 "Energy production and conversion:Energy production and conversion:Malate/lactate dehydrogenases:Malate/lactate dehydrogenases:Glucan phosphorylase:Glucan phosphorylase:Molecular chaperone (small heat shock protein):Molecular chaperone (small heat shock protein):Anaerobic dehydrogenases, typically selenocysteine-containing:Anaerobic dehydrogenases, typically selenocysteine-containing:Phosphotransacetylase:Phosphotransacetylase:Molybdopterin biosynthesis enzyme:Molybdopterin biosynthesis enzyme:Fructose-2,6-bisphosphatase:Fructose-2,6-bisphosphatase:Acetolactate synthase, small (regulatory) subunit:Acetolactate synthase, small (regulatory) subunit:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:ABC-type antimicrobial peptide transport system, permease component:ABC-type antimicrobial peptide transport system, permease component:Rhodanese-related sulfurtransferase:Rhodanese-related sulfurtransferase:Exopolyphosphatase-related proteins:Exopolyphosphatase-related proteins:Signal transduction histidine kinase:Signal transduction histidine kinase:Chemotaxis protein histidine kinase and related kinases:Chemotaxis protein histidine kinase and related kinases:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:Catalase:Catalase:Nitroreductase:Nitroreductase:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Flavodoxin reductases (ferredoxin-NADPH reductases) family 1:Flavodoxin reductases (ferredoxin-NADPH reductases) family 1:Fe-S-cluster-containing hydrogenase components 2:Fe-S-cluster-containing hydrogenase components 2:Peroxiredoxin:Peroxiredoxin:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:ADP-ribosylglycohydrolase:ADP-ribosylglycohydrolase:Multidrug resistance efflux pump:Multidrug resistance efflux pump:4-alpha-glucanotransferase:4-alpha-glucanotransferase:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:FOG: HPt domain:FOG: HPt domain:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Malate synthase:Malate synthase:Molybdenum cofactor biosynthesis enzyme:Molybdenum cofactor biosynthesis enzyme:Uncharacterized conserved protein:Uncharacterized conserved protein:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:catalytic activity:acetolactate synthase activity:catalase activity:4-alpha-glucanotransferase activity:dihydrolipoyl dehydrogenase activity:ATP-dependent peptidase activity:glutamate synthase (NADPH) activity:L-lactate dehydrogenase activity:malate synthase activity:protein histidine kinase activity:thiosulfate sulfurtransferase activity:signal transducer activity:transporter activity:iron ion binding:ATP binding:carbohydrate metabolic process:fructose 2,6-bisphosphate metabolic process:glycolysis:glyoxylate cycle:tricarboxylic acid cycle:tricarboxylic acid cycle intermediate metabolic process:fermentation:electron transport:regulation of transcription, DNA-dependent:proteolysis:cellular aromatic compound metabolic process:Mo-molybdopterin cofactor biosynthetic process:transport:amino acid transport:chemotaxis:response to oxidative stress:signal transduction:metabolic process:glycogen phosphorylase activity:sulfate transport:protein transporter activity:endopeptidase La activity:formate dehydrogenase (NAD+) activity:phosphate acetyltransferase activity:protein-glutamate methylesterase activity:electron carrier activity:branched chain family amino acid biosynthetic process:valine biosynthetic process:protein secretion:glutamate synthase (NADH) activity:mercury (II) reductase activity:antioxidant activity:oxidoreductase activity:amino acid binding:transferase activity, transferring acyl groups other than amino-acyl groups:hydrolase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides:isomerase activity:peptidyl-histidine phosphorylation:heme binding:manganese ion binding:molybdenum ion binding:pyridoxal phosphate binding:cation binding:cellular respiration:cell redox homeostasis:metal ion binding:transition metal ion binding:flavin adenine dinucleotide binding:iron-sulfur cluster binding:4 iron, 4 sulfur cluster binding:peroxiredoxin activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Fructose and mannose metabolism:Fructose and mannose metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Tryptophan metabolism:Tryptophan metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Pyruvate metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Propanoate metabolism:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Methane metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Sulfur relay system:Sulfur relay system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:acolac_sm:acolac_sm:malQ:malQ:sensory_box:sensory_box:malate_syn_G:malate_syn_G:formate-DH-alph:formate-DH-alph:L-LDH-NAD:L-LDH-NAD:more_P_ylases:more_P_ylases:moaA:moaA:Defense mechanisms:Defense mechanisms:Biosynthesis and degradation of polysaccharides:TCA cycle:Regulatory functions:Small molecule interactions:Amino acid biosynthesis:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Cellular processes and signaling:Metabolism:Poorly characterized:Amino Acid Metabolism:Electron transport:Energy metabolism:Cellular processes and signaling:Energy Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino acid biosynthesis:Regulatory functions:Energy metabolism:Metabolism:Global:Molybdopterin:Pyruvate family:Small molecule interactions:TCA cycle:Biosynthesis and degradation of polysaccharides:Glycolysis/gluconeogenesis:Electron transport:Global:Cellular Processes:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism:Metabolism of Cofactors and Vitamins:Poorly characterized:Metabolism:Carbohydrate Metabolism:Glycolysis/gluconeogenesis" 193 "Energy production and conversion:Energy production and conversion:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Phosphoribosylamine-glycine ligase:Phosphoribosylamine-glycine ligase:ATPases with chaperone activity, ATP-binding subunit:ATPases with chaperone activity, ATP-binding subunit:Glycerol-3-phosphate dehydrogenase:Glycerol-3-phosphate dehydrogenase:Predicted sugar phosphatases of the HAD superfamily:Predicted sugar phosphatases of the HAD superfamily:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:ABC-type sugar transport system, periplasmic component:ABC-type sugar transport system, periplasmic component:Flagellar basal body protein:Flagellar basal body protein:Predicted hydrolase (metallo-beta-lactamase superfamily):Predicted hydrolase (metallo-beta-lactamase superfamily):Predicted acetyltransferase:Predicted acetyltransferase:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:motor activity:4-nitrophenylphosphatase activity:glycerol-3-phosphate dehydrogenase activity:monooxygenase activity:phosphoribosylamine-glycine ligase activity:signal transducer activity:structural molecule activity:transporter activity:protein binding:ATP binding:glycerol-3-phosphate metabolic process:regulation of transcription, DNA-dependent:cellular aromatic compound metabolic process:transport:chemotaxis:signal transduction:N-acetyltransferase activity:metabolic process:endopeptidase Clp activity:transaminase activity:purine base biosynthetic process:hydrolase activity:nucleoside-triphosphatase activity:protein metabolic process:pyridoxal phosphate binding:serine-glyoxylate transaminase activity:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Purine metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:purD:purD:FlgB:FlgB:HAD-SF-IIA:HAD-SF-IIA:ClpA:ClpA:flgA_cterm:flgA_cterm:glycerol3P_GlpA:glycerol3P_GlpA:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Chemotaxis and motility:Unknown function:Enzymes of unknown specificity:Cellular processes and signaling:Metabolism:Poorly characterized:Membrane Transport:Nucleotide Metabolism:Lipid Metabolism:Global:Cellular Processes:Anaerobic:Purine ribonucleotide biosynthesis:Degradation of proteins, peptides, and glycopeptides:Chemotaxis and motility:Enzymes of unknown specificity:Energy metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Protein fate:Cellular processes:Unknown function:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Lipid Metabolism:Nucleotide Metabolism:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Anaerobic:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein fate" 194 "Membrane protease subunits, stomatin/prohibitin homologs:Membrane protease subunits, stomatin/prohibitin homologs:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:Integral membrane protein, interacts with FtsH:Integral membrane protein, interacts with FtsH:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:Enzyme related to GTP cyclohydrolase I:Enzyme related to GTP cyclohydrolase I:Acyl carrier protein phosphodiesterase:Acyl carrier protein phosphodiesterase:Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster:Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster:Highly conserved protein containing a thioredoxin domain:Highly conserved protein containing a thioredoxin domain:Uncharacterized conserved protein:Uncharacterized conserved protein:Tetraacyldisaccharide-1-P 4'-kinase:Tetraacyldisaccharide-1-P 4'-kinase:Flagellar motor switch protein:Flagellar motor switch protein:Cation transport ATPase:Cation transport ATPase:Leu/Phe-tRNA-protein transferase:Leu/Phe-tRNA-protein transferase:Flp pilus assembly protein TadG:Flp pilus assembly protein TadG:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:ciliary or flagellar motility:nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:motor activity:catalytic activity:GTP cyclohydrolase I activity:copper-exporting ATPase activity:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity:thymidylate kinase activity:aspartate-tRNA ligase activity:copper ion binding:calcium ion binding:protein binding:ATP binding:electron transport:regulation of transcription, DNA-dependent:proteolysis:copper ion transport:chemotaxis:ATP-dependent helicase activity:metabolic process:peptidase activity:[acyl-carrier-protein] phosphodiesterase activity:leucyltransferase activity:tetraacyldisaccharide 4'-kinase activity:lipid A biosynthetic process:oxidoreductase activity:aromatic compound biosynthetic process:protein catabolic process:preQ1 synthase activity:metal ion transmembrane transporter activity:coenzyme binding:Lipid transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Metabolic pathways:Metabolic pathways:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00003:TIGR00003:aat:aat:lpxK:lpxK:fliM_switch:fliM_switch:QueF-II:QueF-II:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Cations and iron carrying compounds:Cellular processes:Chemotaxis and motility:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cell envelope:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Transport and binding proteins:Information storage and processing:Protein fate:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Chemotaxis and motility:Cations and iron carrying compounds:Protein fate:Metabolism:Global:Degradation of proteins, peptides, and glycopeptides:Global:Cellular Processes:Metabolism:Metabolism:Cell Motility:Glycan Biosynthesis and Metabolism:Cell Motility:Cellular Processes:Glycan Biosynthesis and Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Transport and binding proteins" 195 "Geranylgeranyl pyrophosphate synthase:Geranylgeranyl pyrophosphate synthase:Ribonucleotide reductase, alpha subunit:Ribonucleotide reductase, alpha subunit:Prolyl-tRNA synthetase:Prolyl-tRNA synthetase:GMP synthase, PP-ATPase domain/subunit:GMP synthase, PP-ATPase domain/subunit:Predicted permeases:Predicted permeases:Fe2+/Zn2+ uptake regulation proteins:Fe2+/Zn2+ uptake regulation proteins:ABC-type metal ion transport system, periplasmic component/surface adhesin:ABC-type metal ion transport system, periplasmic component/surface adhesin:Membrane-fusion protein:Membrane-fusion protein:ABC-type Mn2+/Zn2+ transport systems, permease components:ABC-type Mn2+/Zn2+ transport systems, permease components:ABC-type Mn/Zn transport systems, ATPase component:ABC-type Mn/Zn transport systems, ATPase component:Deoxyxylulose-5-phosphate synthase:Deoxyxylulose-5-phosphate synthase:D-alanine-D-alanine ligase and related ATP-grasp enzymes:D-alanine-D-alanine ligase and related ATP-grasp enzymes:Exonuclease VII, large subunit:Exonuclease VII, large subunit:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain:ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain:Predicted permeases:Predicted permeases:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Nucleotide transport and metabolism:Nucleotide transport and metabolism:nucleotide binding:nucleic acid binding:sequence-specific DNA binding transcription factor activity:GMP synthase activity:GMP synthase (glutamine-hydrolyzing) activity:asparagine synthase (glutamine-hydrolyzing) activity:geranyltranstransferase activity:ribonucleoside-diphosphate reductase activity:thymidylate synthase activity:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity:proline-tRNA ligase activity:binding:protein binding:ATP binding:GMP biosynthetic process:DNA replication:DNA catabolic process:regulation of transcription, DNA-dependent:prolyl-tRNA aminoacylation:proteolysis:asparagine biosynthetic process:glutamine metabolic process:transport:tRNA processing:transcription factor binding:peptidase activity:isoprenoid biosynthetic process:protein transporter activity:1-deoxy-D-xylulose-5-phosphate synthase activity:D-alanine-D-alanine ligase activity:dTDP-4-dehydrorhamnose 3,5-epimerase activity:exodeoxyribonuclease VII activity:lipopolysaccharide biosynthetic process:peptidoglycan biosynthetic process:protein secretion:protein transport:terpenoid biosynthetic process:transferase activity:ATPase activity:nucleoside-triphosphatase activity:thiamine pyrophosphate binding:cobalamin binding:ATPase activity, coupled to transmembrane movement of substances:thymidylate synthase biosynthetic process:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:D-Alanine metabolism:D-Alanine metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Polyketide sugar unit biosynthesis:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Mismatch repair:Mismatch repair:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:dxs:dxs:xseA:xseA:proS_fam_II:proS_fam_II:rarD:rarD:guaA_Cterm:guaA_Cterm:D_ala_D_alaTIGR:D_ala_D_alaTIGR:rmlC:rmlC:type_I_hlyD:type_I_hlyD:NrdJ_Z:NrdJ_Z:type_I_sec_LssB:type_I_sec_LssB:Defense mechanisms:Defense mechanisms:Transport and binding proteins:Unknown substrate:Cellular processes:Pathogenesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation:Biosynthesis of Other Secondary Metabolites:Replication and Repair:Membrane Transport:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:Purine ribonucleotide biosynthesis:2'-Deoxyribonucleotide metabolism:Degradation of DNA:tRNA aminoacylation:Protein and peptide secretion and trafficking:Unknown substrate:Pathogenesis:Thiamine:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Purines, pyrimidines, nucleosides, and nucleotides:DNA metabolism:Protein synthesis:Protein fate:Transport and binding proteins:Cellular processes:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Metabolism of Terpenoids and Polyketides:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Nucleotide Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:2'-Deoxyribonucleotide metabolism:DNA metabolism:Degradation of DNA:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking" 196 "Isopropylmalate/homocitrate/citramalate synthases:Isopropylmalate/homocitrate/citramalate synthases:tRNA nucleotidyltransferase/poly(A) polymerase:tRNA nucleotidyltransferase/poly(A) polymerase:Uncharacterized homolog of PSP1:Uncharacterized homolog of PSP1:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Amino acid transport and metabolism:RNA binding:2-isopropylmalate synthase activity:cysteine-type endopeptidase activity:RNA processing:proteolysis:cyclic nucleotide biosynthetic process:nucleotidyltransferase activity:hydrolase activity:phosphorus-oxygen lyase activity:carboxylic acid metabolic process:manganese ion binding:intracellular signal transduction:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Function unknown:Function unknown:GGDEF:GGDEF:LeuA_rel:LeuA_rel:Carbohydrate Metabolism:Metabolism:Amino Acid Metabolism:Poorly characterized:Global:Metabolism:Metabolism:Information storage and processing:Signal transduction:Unknown function:Unknown function:General:Signal transduction:Other:Information storage and processing:Metabolism:Poorly characterized:Other:General:Global:Metabolism:Metabolism:Amino Acid Metabolism:Carbohydrate Metabolism" 197 "Energy production and conversion:Energy production and conversion:Predicted divalent heavy-metal cations transporter:Predicted divalent heavy-metal cations transporter:Glycosyltransferase:Glycosyltransferase:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:Periplasmic protein involved in polysaccharide export:Periplasmic protein involved in polysaccharide export:Chromate transport protein ChrA:Chromate transport protein ChrA:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Nitrogenase molybdenum-iron protein, alpha and beta chains:Nitrogenase molybdenum-iron protein, alpha and beta chains:Predicted ATPase:Predicted ATPase:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Mu-like prophage protein gp29:Mu-like prophage protein gp29:Type III secretory pathway, component EscT:Type III secretory pathway, component EscT:Phage-related terminase:Phage-related terminase:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:catalytic activity:receptor activity:transporter activity:ATP binding:malate metabolic process:electron transport:regulation of transcription, DNA-dependent:protein targeting:transport:transcription factor binding:biosynthetic process:nitrogen fixation:chromate transmembrane transporter activity:polysaccharide transmembrane transporter activity:chromate transport:polysaccharide transport:nitrogenase activity:oxidoreductase activity:malate dehydrogenase activity:iron-iron nitrogenase activity:molybdenum-iron nitrogenase activity:vanadium-iron nitrogenase activity:nucleoside-triphosphatase activity:metal ion transport:metal ion transmembrane transporter activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:2A51:2A51:nifD:nifD:fliR_like_III:fliR_like_III:primase_Cterm:primase_Cterm:PEP_exosort:PEP_exosort:pepcterm_hypo_1:pepcterm_hypo_1:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Global:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Energy Metabolism:Metabolism:Poorly characterized:Metabolism:Central intermediary metabolism:Nitrogen fixation:Regulatory functions:Small molecule interactions:Transport and binding proteins:Anions:Cellular processes:Pathogenesis:Mobile and extrachromosomal element functions:Prophage functions:Cell envelope:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing:Cell envelope:Mobile and extrachromosomal element functions:Cellular processes:Transport and binding proteins:Regulatory functions:Central intermediary metabolism:Surface structures:Prophage functions:Pathogenesis:Anions:Small molecule interactions:Nitrogen fixation:Global:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Xenobiotics Biodegradation and Metabolism:Energy Metabolism" 198 "Glucose-6-phosphate isomerase:Glucose-6-phosphate isomerase:Dihydropteroate synthase and related enzymes:Dihydropteroate synthase and related enzymes:Membrane protease subunits, stomatin/prohibitin homologs:Membrane protease subunits, stomatin/prohibitin homologs:Thiamine monophosphate synthase:Thiamine monophosphate synthase:Deoxyribodipyrimidine photolyase:Deoxyribodipyrimidine photolyase:Glycosyltransferase:Glycosyltransferase:Predicted acid phosphatase:Predicted acid phosphatase:SAM-dependent methyltransferases:SAM-dependent methyltransferases:Signal transduction histidine kinase:Signal transduction histidine kinase:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain:Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain:Predicted signal transduction protein:Predicted signal transduction protein:Flagellar motor switch protein:Flagellar motor switch protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Anaerobic glycerol-3-phosphate dehydrogenase:Anaerobic glycerol-3-phosphate dehydrogenase:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Iron only hydrogenase large subunit, C-terminal domain:Iron only hydrogenase large subunit, C-terminal domain:Predicted ATP-dependent Lon-type protease:Predicted ATP-dependent Lon-type protease:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:sequence-specific DNA binding transcription factor activity:motor activity:catalytic activity:deoxyribodipyrimidine photo-lyase activity:acid phosphatase activity:dihydropteroate synthase activity:glucose-6-phosphate isomerase activity:glycerol-3-phosphate dehydrogenase activity:protein histidine kinase activity:thiamine-phosphate diphosphorylase activity:signal transducer activity:transporter activity:iron ion binding:protein binding:ATP binding:gluconeogenesis:glycolysis:electron transport:DNA repair:regulation of transcription, DNA-dependent:transport:chemotaxis:response to stress:signal transduction:transcription factor binding:NADH dehydrogenase (ubiquinone) activity:metabolic process:methyltransferase activity:peptidase activity:5'-nucleotidase activity:3'-nucleotidase activity:lipid biosynthetic process:cyclopropane-fatty-acyl-phospholipid synthase activity:endopeptidase La activity:ferredoxin hydrogenase activity:protein-glutamate methylesterase activity:electron carrier activity:biosynthetic process:thiamine biosynthetic process:folic acid-containing compound biosynthetic process:response to external stimulus:nucleoside-triphosphatase activity:IMP-GMP specific 5'-nucleotidase activity:peptidyl-histidine phosphorylation:heme binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Methane metabolism:Methane metabolism:Thiamine metabolism:Thiamine metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Folate biosynthesis:Folate biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:surE:surE:sensory_box:sensory_box:HDIG:HDIG:thiE:thiE:fliM_switch:fliM_switch:DHPS:DHPS:HEQRo_perm_3TM:HEQRo_perm_3TM:FeFe_hydrog_A:FeFe_hydrog_A:TIGR02688:TIGR02688:glycerol3P_GlpB:glycerol3P_GlpB:Energy metabolism:Anaerobic:Regulatory functions:Small molecule interactions:Transport and binding proteins:Amino acids, peptides and amines:Cellular processes:Adaptations to atypical conditions:Chemotaxis and motility:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Energy Metabolism:Carbohydrate Metabolism:Metabolism of Cofactors and Vitamins:Signal Transduction:Cell Motility:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Hypothetical proteins:Cellular processes:Transport and binding proteins:Regulatory functions:Energy metabolism:Thiamine:Folic acid:Conserved:Chemotaxis and motility:Adaptations to atypical conditions:Amino acids, peptides and amines:Small molecule interactions:Anaerobic:Global:Cellular Processes:Lipid Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Energy Metabolism:Carbohydrate Metabolism:Metabolism:Environmental Information Processing:Signal Transduction:Poorly characterized:Cellular Processes:Cell Motility:Metabolism:Cellular processes and signaling:Global:Metabolism:Information storage and processing:Lipid Metabolism:Nucleotide Metabolism:Environmental Information Processing" 199 "Periplasmic serine proteases (ClpP class):Periplasmic serine proteases (ClpP class):Putative secretion activating protein:Putative secretion activating protein:Phage-related holin (Lysis protein):Phage-related holin (Lysis protein):calcium ion binding:proteolysis:peptidase activity:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:General function prediction only:General function prediction only:holin_tox_secr:holin_tox_secr:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Poorly characterized:Poorly characterized:Cellular processes and signaling:Mobile and extrachromosomal element functions:Mobile and extrachromosomal element functions:Prophage functions:Prophage functions" 200 "Diaminopimelate decarboxylase:Diaminopimelate decarboxylase:Biotin carboxylase:Biotin carboxylase:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Lipid A core - O-antigen ligase and related enzymes:Lipid A core - O-antigen ligase and related enzymes:Predicted ATP-grasp enzyme:Predicted ATP-grasp enzyme:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:transmembrane receptor protein tyrosine kinase activity:non-membrane spanning protein tyrosine kinase activity:ATP binding:regulation of transcription, DNA-dependent:transcription factor binding:diaminopimelate decarboxylase activity:cobalamin biosynthetic process:pathogenesis:transferase activity, transferring acyl groups other than amino-acyl groups:nucleoside-triphosphatase activity:pyridoxal phosphate binding:enzyme regulator activity:cobyrinic acid a,c-diamide synthase activity:capsule polysaccharide biosynthetic process:regulation of protein secretion:Lipid transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:eps_fam:eps_fam:8TM_EpsH:8TM_EpsH:Metabolism:Poorly characterized:Cellular processes and signaling:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Poorly characterized:Metabolism:Transport and binding proteins:Protein fate:Carbohydrates, organic alcohols, and acids:Protein and peptide secretion and trafficking:Cellular processes and signaling" 201 "Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Predicted metal-dependent phosphoesterases (PHP family):Predicted metal-dependent phosphoesterases (PHP family):Signal transduction histidine kinase:Signal transduction histidine kinase:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:Enzyme related to GTP cyclohydrolase I:Enzyme related to GTP cyclohydrolase I:BioD-like N-terminal domain of phosphotransacetylase:BioD-like N-terminal domain of phosphotransacetylase:Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster:Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster:K+-transporting ATPase, c chain:K+-transporting ATPase, c chain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized conserved protein:Uncharacterized conserved protein:two-component sensor activity:nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA-directed DNA polymerase activity:GTP cyclohydrolase I activity:ATP binding:DNA replication:regulation of transcription, DNA-dependent:potassium ion transport:response to stress:signal transduction:ATP-dependent helicase activity:transcription factor binding:potassium-transporting ATPase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:aromatic compound biosynthetic process:preQ1 synthase activity:metal ion binding:4 iron, 4 sulfur cluster binding:Replication, recombination and repair:Replication, recombination and repair:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Two-component system:Two-component system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:kdpC:kdpC:QueF-II:QueF-II:Cellular processes and signaling:Information storage and processing:Cations and iron carrying compounds:Transport and binding proteins:Signal Transduction:Transport and binding proteins:Cations and iron carrying compounds:Environmental Information Processing:Signal Transduction:Environmental Information Processing:Poorly characterized:Metabolism:Cellular processes and signaling:Metabolism:Information storage and processing:Poorly characterized" 202 "Energy production and conversion:Energy production and conversion:Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog):Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog):Pseudouridylate synthases, 23S RNA-specific:Pseudouridylate synthases, 23S RNA-specific:tRNA nucleotidyltransferase/poly(A) polymerase:tRNA nucleotidyltransferase/poly(A) polymerase:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Ferredoxin:Ferredoxin:Predicted helicases:Predicted helicases:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Cobyric acid synthase:Cobyric acid synthase:DnaK suppressor protein:DnaK suppressor protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Butyrate kinase:Butyrate kinase:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Flp pilus assembly protein TadD, contains TPR repeats:Flp pilus assembly protein TadD, contains TPR repeats:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):pseudouridine synthesis:nucleic acid binding:sequence-specific DNA binding transcription factor activity:RNA binding:catalytic activity:dephospho-CoA kinase activity:binding:ATP binding:fermentation:electron transport:regulation of transcription, DNA-dependent:RNA processing:translation:glutamyl-tRNA aminoacylation:amino acid transport:chemotaxis:signal transduction:ATP-dependent helicase activity:transcription factor binding:zinc ion binding:electron carrier activity:cobalamin biosynthetic process:pseudouridine synthase activity:coenzyme A biosynthetic process:phosphorylation:phosphotransferase activity, carboxyl group as acceptor:nucleotidyltransferase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:molybdenum ion binding:pyridoxal phosphate binding:cobyrinic acid a,c-diamide synthase activity:butyrate kinase activity:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity:iron-sulfur cluster binding:adenosylcobyric acid synthase (glutamine-hydrolyzing) activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell motility:Cell motility:Butanoate metabolism:Butanoate metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:rluA_subfam:rluA_subfam:gatB:gatB:sensory_box:sensory_box:TIGR00296:TIGR00296:cobQ:cobQ:cas3_core:cas3_core:butyr_kinase:butyr_kinase:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Regulatory functions:Energy metabolism:Fermentation:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Mobile and extrachromosomal element functions:Other:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Information storage and processing:Carbohydrate Metabolism:Heme, porphyrin, and cobalamin:General:Other:tRNA and rRNA base modification:tRNA aminoacylation:Small molecule interactions:Fermentation:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Translation:Metabolism of Cofactors and Vitamins:Energy metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism of Cofactors and Vitamins:Unknown function:Genetic Information Processing:Translation:Mobile and extrachromosomal element functions:Environmental Information Processing:Membrane Transport:Protein synthesis:Global" 203 "Energy production and conversion:Energy production and conversion:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Glycerol-3-phosphate dehydrogenase:Glycerol-3-phosphate dehydrogenase:tRNA nucleotidyltransferase/poly(A) polymerase:tRNA nucleotidyltransferase/poly(A) polymerase:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains):ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains):Predicted GTPases:Predicted GTPases:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:two-component sensor activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:DNA-directed DNA polymerase activity:GTPase activity:ATP-dependent DNA helicase activity:glycerol-3-phosphate dehydrogenase activity:ATP binding:GTP binding:glycerol-3-phosphate metabolic process:DNA repair:regulation of transcription, DNA-dependent:RNA processing:chemotaxis:transcription factor binding:5'-nucleotidase activity:nucleotidyltransferase activity:nucleoside-triphosphatase activity:IMP-GMP specific 5'-nucleotidase activity:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Glycerophospholipid metabolism:Glycerophospholipid metabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00157:TIGR00157:sensory_box:sensory_box:Translation factors:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Lipid Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Protein synthesis:Regulatory functions:Translation factors:Small molecule interactions:Metabolism:Lipid Metabolism:Small molecule interactions:Regulatory functions:Protein synthesis" 204 "Predicted ATPase:Predicted ATPase:Putative secretion activating protein:Putative secretion activating protein:Mu-like prophage tail sheath protein gpL:Mu-like prophage tail sheath protein gpL:Phage-related holin (Lysis protein):Phage-related holin (Lysis protein):Bacteriophage capsid protein:Bacteriophage capsid protein:DNA binding:calcium ion binding:metabolic process:General function prediction only:General function prediction only:portal_lambda:portal_lambda:holin_tox_secr:holin_tox_secr:primase_Cterm:primase_Cterm:Mobile and extrachromosomal element functions:Mobile and extrachromosomal element functions:Prophage functions:Prophage functions:Poorly characterized:Poorly characterized" 205 "Energy production and conversion:Energy production and conversion:Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Flagellar motor component:Flagellar motor component:Flagellar motor protein:Flagellar motor protein:Periplasmic protein involved in polysaccharide export:Periplasmic protein involved in polysaccharide export:Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain:Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain:Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase:Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase:FOG: GGDEF domain:FOG: GGDEF domain:Response regulator:Response regulator:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:motor activity:acetolactate synthase activity:fumarate hydratase activity:uracil phosphoribosyltransferase activity:signal transducer activity:regulation of transcription, DNA-dependent:transport:chemotaxis:response to stress:signal transduction:metabolic process:protein transporter activity:nucleoside metabolic process:cyclic nucleotide biosynthetic process:polysaccharide transmembrane transporter activity:polysaccharide transport:amino acid binding:phosphorus-oxygen lyase activity:intracellular signal transduction:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Pyrimidine metabolism:Pyrimidine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Signal transduction mechanisms:Signal transduction mechanisms:GGDEF:GGDEF:ttdB_fumA_fumB:ttdB_fumA_fumB:Metabolism:Cell Motility:Signal Transduction:Metabolism:Metabolism:Environmental Information Processing:Cellular Processes:Global:Other:Signal transduction:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Cellular processes and signaling:Metabolism:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Signal transduction:Other:Cellular processes and signaling" 206 "Prephenate dehydratase:Prephenate dehydratase:5-enolpyruvylshikimate-3-phosphate synthase:5-enolpyruvylshikimate-3-phosphate synthase:Tryptophan synthase beta chain:Tryptophan synthase beta chain:Indole-3-glycerol phosphate synthase:Indole-3-glycerol phosphate synthase:Phosphoribosylanthranilate isomerase:Phosphoribosylanthranilate isomerase:Anthranilate/para-aminobenzoate synthases component I:Anthranilate/para-aminobenzoate synthases component I:Tryptophan synthase alpha chain:Tryptophan synthase alpha chain:S-adenosylmethionine synthetase:S-adenosylmethionine synthetase:Cytidylate kinase:Cytidylate kinase:Prephenate dehydrogenase:Prephenate dehydrogenase:Panthothenate synthetase:Panthothenate synthetase:Glycosyltransferase:Glycosyltransferase:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:S-adenosylhomocysteine hydrolase:S-adenosylhomocysteine hydrolase:Anthranilate/para-aminobenzoate synthases component II:Anthranilate/para-aminobenzoate synthases component II:Anthranilate phosphoribosyltransferase:Anthranilate phosphoribosyltransferase:ATPase involved in DNA replication initiation:ATPase involved in DNA replication initiation:5,10-methylenetetrahydrofolate reductase:5,10-methylenetetrahydrofolate reductase:ABC-type spermidine/putrescine transport system, permease component I:ABC-type spermidine/putrescine transport system, permease component I:Predicted alternative 3-dehydroquinate synthase:Predicted alternative 3-dehydroquinate synthase:3-deoxy-D-manno-octulosonic-acid transferase:3-deoxy-D-manno-octulosonic-acid transferase:DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes:DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes:Methylase involved in ubiquinone/menaquinone biosynthesis:Methylase involved in ubiquinone/menaquinone biosynthesis:Predicted membrane protein:Predicted membrane protein:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:tryptophan biosynthetic process:nucleotide binding:DNA replication origin binding:sequence-specific DNA binding transcription factor activity:peptidyl-prolyl cis-trans isomerase activity:3-deoxy-7-phosphoheptulonate synthase activity:3-dehydroquinate synthase activity:3-phosphoshikimate 1-carboxyvinyltransferase activity:adenosylhomocysteinase activity:anthranilate phosphoribosyltransferase activity:anthranilate synthase activity:chorismate mutase activity:cytidylate kinase activity:aspartic-type endopeptidase activity:fructose-bisphosphate aldolase activity:indole-3-glycerol-phosphate synthase activity:methionine adenosyltransferase activity:methylenetetrahydrofolate reductase (NADPH) activity:monooxygenase activity:pantoate-beta-alanine ligase activity:cyclophilin:phosphoribosylanthranilate isomerase activity:prephenate dehydratase activity:prephenate dehydrogenase (NADP+) activity:shikimate kinase activity:tryptophan synthase activity:transporter activity:iron ion binding:ATP binding:sugar binding:carbohydrate metabolic process:nucleobase-containing compound metabolic process:DNA-dependent DNA replication initiation:regulation of DNA replication:regulation of transcription, DNA-dependent:protein folding:proteolysis:cellular amino acid metabolic process:glutamine metabolic process:methionine metabolic process:tryptophan metabolic process:tyrosine biosynthetic process:one-carbon metabolic process:transport:anion transport:response to stress:metabolic process:methyltransferase activity:prephenate dehydrogenase activity:biosynthetic process:methionine biosynthetic process:L-phenylalanine biosynthetic process:cobalamin biosynthetic process:protein transport:pantothenate biosynthetic process:amino acid binding:transferase activity:ligase activity:nucleoside-triphosphatase activity:FK506-sensitive peptidyl-prolyl cis-trans isomerase:pyridoxal phosphate binding:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:cobyrinic acid a,c-diamide synthase activity:4-amino-4-deoxychorismate synthase activity:cyclohexadienyl dehydrogenase activity:methionine adenosyltransferase regulator activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Fructose and mannose metabolism:Fructose and mannose metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Novobiocin biosynthesis:Selenocompound metabolism:Selenocompound metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:One carbon pool by folate:One carbon pool by folate:Methane metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Function unknown:Function unknown:cmk:cmk:panC:panC:trpA:trpA:trpB:trpB:trpG_papA:trpG_papA:fadh2:fadh2:ahcY:ahcY:metK:metK:trpD:trpD:AroFGH_arch:AroFGH_arch:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Membrane Transport:Signal Transduction:Amino Acid Metabolism:Metabolism:Energy metabolism:Central intermediary metabolism:Other:Energy metabolism:Amino acids and amines:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Amino acid biosynthesis:Aromatic amino acid family:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism of Other Amino Acids:Nucleotide Metabolism:Energy Metabolism:Metabolism:Environmental Information Processing:Global:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Amino acids and amines:Nucleotide and nucleoside interconversions:Aromatic amino acid family:Aspartate family:Pantothenate and coenzyme A:Central intermediary metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Carbohydrate Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Amino acid biosynthesis:Energy Metabolism:Global:Signal Transduction:Metabolism:Membrane Transport:Environmental Information Processing" 207 "Energy production and conversion:Energy production and conversion:FAD/FMN-containing dehydrogenases:FAD/FMN-containing dehydrogenases:Acetate kinase:Acetate kinase:Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:NADH:ubiquinone oxidoreductase 27 kD subunit:NADH:ubiquinone oxidoreductase 27 kD subunit:BioD-like N-terminal domain of phosphotransacetylase:BioD-like N-terminal domain of phosphotransacetylase:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I):Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I):Ni,Fe-hydrogenase III small subunit:Ni,Fe-hydrogenase III small subunit:Ni,Fe-hydrogenase III large subunit:Ni,Fe-hydrogenase III large subunit:electron transporter activity:iron ion binding:ATP binding:organic acid metabolic process:acetyl-CoA biosynthetic process from pyruvate:fermentation:electron transport:mitochondrial electron transport, NADH to ubiquinone:protein folding:protein modification process:NADH dehydrogenase (ubiquinone) activity:metabolic process:acetate kinase activity:formate dehydrogenase (NAD+) activity:glycolate oxidase activity:phosphate acetyltransferase activity:electron carrier activity:cobalamin biosynthetic process:folic acid-containing compound biosynthetic process:nickel ion binding:phosphorylation:pyruvate synthase activity:5-formyltetrahydrofolate cyclo-ligase activity:thiamine pyrophosphate binding:heat shock protein binding:cobyrinic acid a,c-diamide synthase activity:ATP synthesis coupled electron transport:flavin adenine dinucleotide binding:unfolded protein binding:NAD binding:iron-sulfur cluster binding:4 iron, 4 sulfur cluster binding:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Taurine and hypotaurine metabolism:Taurine and hypotaurine metabolism:Pyruvate metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Propanoate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:ackA:ackA:hypA:hypA:pta:pta:pyruv_ox_red:pyruv_ox_red:Energy Metabolism:Carbohydrate Metabolism:Carbohydrate Metabolism:Energy metabolism:Fermentation:Protein fate:Protein modification and repair:Metabolism:Poorly characterized:Metabolism:Poorly characterized:Metabolism:Protein fate:Energy metabolism:Protein modification and repair:Fermentation:Global:Metabolism:Metabolism:Metabolism of Other Amino Acids:Energy Metabolism:Global:Metabolism:Metabolism of Other Amino Acids" 208 "Energy production and conversion:Energy production and conversion:Ornithine carbamoyltransferase:Ornithine carbamoyltransferase:Excinuclease ATPase subunit:Excinuclease ATPase subunit:Glycosyltransferase:Glycosyltransferase:FOG: CBS domain:FOG: CBS domain:Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake:Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Ferredoxin:Ferredoxin:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Dioxygenases related to 2-nitropropane dioxygenase:Dioxygenases related to 2-nitropropane dioxygenase:RecB family exonuclease:RecB family exonuclease:Cytochrome c biogenesis factor:Cytochrome c biogenesis factor:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):DNA binding:catalytic activity:ornithine carbamoyltransferase activity:signal transducer activity:binding:ATP binding:sugar binding:electron transport:nucleotide-excision repair:regulation of transcription, DNA-dependent:protein folding:cellular amino acid metabolic process:chemotaxis:signal transduction:metabolic process:electron carrier activity:biosynthetic process:cyclic nucleotide biosynthetic process:DNA mediated transformation:excinuclease ABC activity:amino acid binding:phosphorus-oxygen lyase activity:ATPase activity:nitronate monooxygenase activity:heat shock protein binding:intracellular signal transduction:unfolded protein binding:iron-sulfur cluster binding:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Nucleotide excision repair:Nucleotide excision repair:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:uvra:uvra:orni_carb_tr:orni_carb_tr:dprA:dprA:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Amino acid biosynthesis:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Small molecule interactions:DNA replication, recombination, and repair:DNA transformation:Glutamate family:Regulatory functions:DNA metabolism:Cellular processes:Amino acid biosynthesis:Signal Transduction:Replication and Repair:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Cellular processes:DNA transformation:Cell Motility:Glutamate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 209 "Energy production and conversion:Energy production and conversion:Peptide methionine sulfoxide reductase:Peptide methionine sulfoxide reductase:Conserved domain frequently associated with peptide methionine sulfoxide reductase:Conserved domain frequently associated with peptide methionine sulfoxide reductase:DnaJ-class molecular chaperone with C-terminal Zn finger domain:DnaJ-class molecular chaperone with C-terminal Zn finger domain:Thioredoxin reductase:Thioredoxin reductase:NifU homolog involved in Fe-S cluster formation:NifU homolog involved in Fe-S cluster formation:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulator of heat shock gene:Transcriptional regulator of heat shock gene:Flagellar basal body rod protein:Flagellar basal body rod protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Copper chaperone:Copper chaperone:Amino acid transport and metabolism:Amino acid transport and metabolism:ciliary or flagellar motility:sequence-specific DNA binding transcription factor activity:motor activity:thioredoxin-disulfide reductase activity:structural molecule activity:copper ion transmembrane transporter activity:iron ion binding:copper ion binding:electron transport:regulation of transcription, DNA-dependent:protein folding:copper ion transport:peptide-methionine-(S)-S-oxide reductase activity:biosynthetic process:disulfide oxidoreductase activity:iron-sulfur cluster assembly:transferase activity, transferring nitrogenous groups:protein metabolic process:pyridoxal phosphate binding:heat shock protein binding:peptide-methionine (R)-S-oxide reductase activity:unfolded protein binding:iron-sulfur cluster binding:Transcription:Transcription:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Flagellar assembly:Flagellar assembly:Function unknown:Function unknown:hrcA:hrcA:TIGR00357:TIGR00357:msrA:msrA:NifU_proper:NifU_proper:DNA interactions:Cellular processes:Adaptations to atypical conditions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing:Nitrogen fixation:Cell Motility:Nucleotide Metabolism:Metabolism:DNA interactions:Cellular Processes:Cellular processes:Regulatory functions:Central intermediary metabolism:Adaptations to atypical conditions:Nucleotide Metabolism:Metabolism:Poorly characterized:Cellular Processes:Cell Motility:Metabolism:Central intermediary metabolism:Nitrogen fixation:Regulatory functions" 210 "5-formyltetrahydrofolate cyclo-ligase:5-formyltetrahydrofolate cyclo-ligase:FOG: CheY-like receiver:FOG: CheY-like receiver:Uncharacterized conserved protein:Uncharacterized conserved protein:two-component response regulator activity:two-component signal transduction system (phosphorelay):ATP binding:regulation of transcription, DNA-dependent:folic acid-containing compound biosynthetic process:5-formyltetrahydrofolate cyclo-ligase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:One carbon pool by folate:One carbon pool by folate:Metabolic pathways:Metabolic pathways:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:PEP_exosort:PEP_exosort:MTHFS_bact:MTHFS_bact:Poorly characterized:Metabolism of Cofactors and Vitamins:Metabolism:Metabolism:Global:One-carbon metabolism:Surface structures:Central intermediary metabolism:Cell envelope:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Central intermediary metabolism:One-carbon metabolism:Cell envelope:Surface structures:Cellular processes and signaling:Metabolism" 211 "Energy production and conversion:Energy production and conversion:ABC-type phosphate transport system, periplasmic component:ABC-type phosphate transport system, periplasmic component:Asparagine synthase (glutamine-hydrolyzing):Asparagine synthase (glutamine-hydrolyzing):Aspartate/tyrosine/aromatic aminotransferase:Aspartate/tyrosine/aromatic aminotransferase:ABC-type phosphate transport system, permease component:ABC-type phosphate transport system, permease component:Predicted metal-dependent phosphoesterases (PHP family):Predicted metal-dependent phosphoesterases (PHP family):ABC-type Fe3+-hydroxamate transport system, periplasmic component:ABC-type Fe3+-hydroxamate transport system, periplasmic component:Predicted permeases:Predicted permeases:Peroxiredoxin:Peroxiredoxin:Histidinol phosphatase and related hydrolases of the PHP family:Histidinol phosphatase and related hydrolases of the PHP family:Predicted transcriptional regulators:Predicted transcriptional regulators:L-lactate permease:L-lactate permease:TRAP-type C4-dicarboxylate transport system, periplasmic component:TRAP-type C4-dicarboxylate transport system, periplasmic component:Pyruvate-formate lyase:Pyruvate-formate lyase:ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase:ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase:ABC-type tungstate transport system, permease component:ABC-type tungstate transport system, permease component:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Predicted membrane protein:Predicted membrane protein:Type III secretory pathway, lipoprotein EscJ:Type III secretory pathway, lipoprotein EscJ:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:motor activity:catalytic activity:DNA-directed DNA polymerase activity:asparagine synthase (glutamine-hydrolyzing) activity:L-aspartate:2-oxoglutarate aminotransferase activity:transporter activity:inorganic phosphate transmembrane transporter activity:iron ion transmembrane transporter activity:glucose metabolic process:DNA replication:regulation of transcription, DNA-dependent:asparagine biosynthetic process:transport:phosphate ion transport:high-affinity iron ion transport:formate C-acetyltransferase activity:biosynthetic process:flagellum assembly:protein secretion:lactate transmembrane transporter activity:type III protein (virulence-related) secretor activity:lactate transport:1-aminocyclopropane-1-carboxylate synthase activity:pyridoxal phosphate binding:plasmid partitioning:sequence-specific DNA binding:metal ion binding:4 iron, 4 sulfur cluster binding:peroxiredoxin activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Tyrosine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Novobiocin biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Butanoate metabolism:Butanoate metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Flagellar assembly:Flagellar assembly:Bacterial secretion system:Bacterial secretion system:Base excision repair:Base excision repair:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:parB_part:parB_part:dctP:dctP:lctP:lctP:3a0107s02c:3a0107s02c:asn_synth_AEB:asn_synth_AEB:ptsS_2:ptsS_2:III_secr_YscJ:III_secr_YscJ:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Amino Acid Metabolism:Energy Metabolism:Amino Acid Metabolism:Transport and binding proteins:Anions:Carbohydrates, organic alcohols, and acids:Cellular processes:Pathogenesis:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Carbohydrate Metabolism:Amino acid biosynthesis:Cellular processes:Transport and binding proteins:Aspartate family:Pathogenesis:Carbohydrates, organic alcohols, and acids:Anions:Global:Cellular Processes:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Replication and Repair:Biosynthesis of Other Secondary Metabolites:Cellular Processes:Energy Metabolism:Cell Motility:Signal Transduction:Global:Metabolism:Membrane Transport" 212 "Methionine aminopeptidase:Methionine aminopeptidase:Ribosomal protein S10:Ribosomal protein S10:Ribosomal protein L4:Ribosomal protein L4:Ribosomal protein L23:Ribosomal protein L23:Ribosomal protein L2:Ribosomal protein L2:Ribosomal protein L14:Ribosomal protein L14:Ribosomal protein L5:Ribosomal protein L5:Ribosomal protein S19:Ribosomal protein S19:Ribosomal protein L15:Ribosomal protein L15:Ribosomal protein L30/L7E:Ribosomal protein L30/L7E:nucleotide binding:RNA binding:structural constituent of ribosome:methionyl aminopeptidase activity:translation:protein modification process:proteolysis:transferase activity:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Ribosome:Ribosome:met_pdase_I:met_pdase_I:rpsJ_bact:rpsJ_bact:rpsS_bact:rpsS_bact:rplN_bact:rplN_bact:rplO_bact:rplO_bact:rplB_bact:rplB_bact:rpmD_bact:rpmD_bact:rplD_bact:rplD_bact:Protein synthesis:Protein modification and repair:Information storage and processing:Genetic Information Processing:Translation:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein modification and repair:Information storage and processing:Ribosomal proteins: synthesis and modification:Genetic Information Processing:Translation:Protein fate" 213 "Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:DnaK suppressor protein:DnaK suppressor protein:K+-transporting ATPase, A chain:K+-transporting ATPase, A chain:High-affinity K+ transport system, ATPase chain B:High-affinity K+ transport system, ATPase chain B:Uncharacterized ATPase, putative transposase:Uncharacterized ATPase, putative transposase:Predicted acetyltransferase:Predicted acetyltransferase:adenosylmethionine-8-amino-7-oxononanoate transaminase activity:signal transducer activity:calcium ion binding:ATP binding:potassium ion transport:chemotaxis:signal transduction:N-acetyltransferase activity:metabolic process:zinc ion binding:potassium-transporting ATPase activity:biotin biosynthetic process:pyridoxal phosphate binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Biotin metabolism:Biotin metabolism:Metabolic pathways:Metabolic pathways:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:bioA:bioA:kdpA:kdpA:ATPase_P-type:ATPase_P-type:PEP_exosort:PEP_exosort:Metabolism:Transport and binding proteins:Cations and iron carrying compounds:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Cell envelope:Surface structures:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins:Metabolism:Cell Motility:Metabolism:Environmental Information Processing:Cellular Processes:Global:Cations and iron carrying compounds:Biotin:Surface structures:Transport and binding proteins:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Signal Transduction:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global" 214 "Energy production and conversion:Energy production and conversion:Putative translation initiation inhibitor, yjgF family:Putative translation initiation inhibitor, yjgF family:Cytosine deaminase and related metal-dependent hydrolases:Cytosine deaminase and related metal-dependent hydrolases:Fructose-2,6-bisphosphatase:Fructose-2,6-bisphosphatase:ABC-type phosphate transport system, permease component:ABC-type phosphate transport system, permease component:Mg2+ and Co2+ transporters:Mg2+ and Co2+ transporters:Apolipoprotein N-acyltransferase:Apolipoprotein N-acyltransferase:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Pyruvate-formate lyase-activating enzyme:Pyruvate-formate lyase-activating enzyme:Cobyrinic acid a,c-diamide synthase:Cobyrinic acid a,c-diamide synthase:Ni,Fe-hydrogenase I cytochrome b subunit:Ni,Fe-hydrogenase I cytochrome b subunit:FOG: GGDEF domain:FOG: GGDEF domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:HD-GYP domain:HD-GYP domain:DNA G:T-mismatch repair endonuclease:DNA G:T-mismatch repair endonuclease:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:catalytic activity:endonuclease activity:purine-nucleoside phosphorylase activity:transporter activity:inorganic phosphate transmembrane transporter activity:binding:ATP binding:fructose 2,6-bisphosphate metabolic process:glucose metabolic process:electron transport:mismatch repair:regulation of transcription, DNA-dependent:protein modification process:oxygen and reactive oxygen species metabolic process:nitrogen compound metabolic process:transport:phosphate ion transport:chemotaxis:transcription factor binding:metabolic process:guanine deaminase activity:electron carrier activity:cyclic nucleotide biosynthetic process:cobalamin biosynthetic process:N-acyltransferase activity:oxidoreductase activity:hydrolase activity, acting on ester bonds:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:phosphorus-oxygen lyase activity:nucleoside-triphosphatase activity:metal ion transport:intracellular signal transduction:lipoprotein biosynthetic process:cobyrinic acid a,c-diamide synthase activity:[formate-C-acetyltransferase]-activating enzyme activity:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity:metal ion transmembrane transporter activity:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Fructose and mannose metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00004:TIGR00004:GGDEF:GGDEF:cobB:cobB:lnt:lnt:vsr:vsr:phosphate_pstC:phosphate_pstC:PFLE_PFLC:PFLE_PFLC:Anions:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Carbohydrate Metabolism:Other:Heme, porphyrin, and cobalamin:DNA metabolism:Transcription:Protein fate:Transport and binding proteins:Biosynthesis of cofactors, prosthetic groups, and carriers:Signal transduction:Anions:Protein modification and repair:Degradation of RNA:DNA replication, recombination, and repair:Global:Cellular Processes:Environmental Information Processing:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Protein fate:Protein modification and repair:Transport and binding proteins" 215 "Type I restriction-modification system methyltransferase subunit:Type I restriction-modification system methyltransferase subunit:Predicted methyltransferases:Predicted methyltransferases:Nitrogen regulatory protein PII:Nitrogen regulatory protein PII:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:Organic radical activating enzymes:Organic radical activating enzymes:Predicted PP-loop superfamily ATPase:Predicted PP-loop superfamily ATPase:Hypoxanthine-guanine phosphoribosyltransferase:Hypoxanthine-guanine phosphoribosyltransferase:6-pyruvoyl-tetrahydropterin synthase:6-pyruvoyl-tetrahydropterin synthase:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Beta-galactosidase, beta subunit:Beta-galactosidase, beta subunit:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:ABC-type tungstate transport system, permease component:ABC-type tungstate transport system, permease component:Virulence protein:Virulence protein:Putative Zn-dependent protease, contains TPR repeats:Putative Zn-dependent protease, contains TPR repeats:Predicted transcriptional regulator:Predicted transcriptional regulator:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:pseudouridine synthesis:DNA binding:RNA binding:catalytic activity:6-pyruvoyltetrahydropterin synthase activity:metalloendopeptidase activity:hypoxanthine phosphoribosyltransferase activity:pseudouridylate synthase activity:transporter activity:binding:ATP binding:carbohydrate metabolic process:purine ribonucleoside salvage:DNA methylation:regulation of transcription, DNA-dependent:proteolysis:regulation of nitrogen utilization:transport:metabolic process:methyltransferase activity:N-methyltransferase activity:zinc ion binding:site-specific DNA-methyltransferase (adenine-specific) activity:RNA modification:pseudouridine synthase activity:oxidoreductase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:ATPase activity:enzyme regulator activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Purine metabolism:Folate biosynthesis:Folate biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Two-component system:Two-component system:General function prediction only:General function prediction only:Function unknown:Function unknown:TIGR00022:TIGR00022:TIGR00093:TIGR00093:TIGR00096:TIGR00096:TIGR00364:TIGR00364:hsdM:hsdM:HGPRTase:HGPRTase:CxxC_CxxC_SSSS:CxxC_CxxC_SSSS:queuosine_QueD:queuosine_QueD:Defense mechanisms:Defense mechanisms:Metabolism:Signal Transduction:Membrane Transport:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:tRNA and rRNA base modification:Restriction/modification:Enzymes of unknown specificity:General:Purines, pyrimidines, nucleosides, and nucleotides:Regulatory functions:DNA metabolism:Protein synthesis:Unknown function:DNA interactions:Salvage of nucleosides and nucleotides:Global:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:Regulatory functions:DNA interactions:DNA metabolism:Restriction/modification:Protein synthesis:tRNA and rRNA base modification:Unknown function:Enzymes of unknown specificity:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Metabolism" 216 "Energy production and conversion:Energy production and conversion:Peroxiredoxin:Peroxiredoxin:S-adenosylhomocysteine hydrolase:S-adenosylhomocysteine hydrolase:5,10-methylenetetrahydrofolate reductase:5,10-methylenetetrahydrofolate reductase:Fe2+/Zn2+ uptake regulation proteins:Fe2+/Zn2+ uptake regulation proteins:Cell wall-associated hydrolases (invasion-associated proteins):Cell wall-associated hydrolases (invasion-associated proteins):Cytochrome bd-type quinol oxidase, subunit 1:Cytochrome bd-type quinol oxidase, subunit 1:Cytochrome bd-type quinol oxidase, subunit 2:Cytochrome bd-type quinol oxidase, subunit 2:Amidases related to nicotinamidase:Amidases related to nicotinamidase:Rubrerythrin:Rubrerythrin:Rubredoxin:Rubredoxin:Pyridoxal phosphate biosynthesis protein:Pyridoxal phosphate biosynthesis protein:Putative protein-S-isoprenylcysteine methyltransferase:Putative protein-S-isoprenylcysteine methyltransferase:Peroxiredoxin:Peroxiredoxin:Methylase involved in ubiquinone/menaquinone biosynthesis:Methylase involved in ubiquinone/menaquinone biosynthesis:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Amino acid transport and metabolism:Amino acid transport and metabolism:rRNA modification:nucleic acid binding:sequence-specific DNA binding transcription factor activity:RNA binding:double-stranded RNA adenosine deaminase activity:catalytic activity:adenosylhomocysteinase activity:methylenetetrahydrofolate reductase (NADPH) activity:phosphopyruvate hydratase activity:electron transport:regulation of transcription, DNA-dependent:RNA processing:one-carbon metabolic process:response to oxidative stress:metabolic process:methyltransferase activity:RNA methyltransferase activity:zinc ion binding:thioredoxin peroxidase activity:pyridoxine biosynthetic process:rRNA methyltransferase activity:electron carrier activity:methionine biosynthetic process:oxidoreductase activity:metal ion binding:transition metal ion binding:glycolaldehyde dehydrogenase activity:4-hydroxythreonine-4-phosphate dehydrogenase activity:NAD binding:peroxiredoxin activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Oxidative phosphorylation:Oxidative phosphorylation:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Histidine metabolism:Histidine metabolism:Tyrosine metabolism:Tyrosine metabolism:Selenocompound metabolism:Selenocompound metabolism:Polycyclic aromatic hydrocarbon degradation:Polycyclic aromatic hydrocarbon degradation:One carbon pool by folate:One carbon pool by folate:Methane metabolism:Methane metabolism:Vitamin B6 metabolism:Vitamin B6 metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:cydB:cydB:rumA:rumA:pdxA:pdxA:fadh2:fadh2:ahcY:ahcY:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Energy Metabolism:Energy metabolism:Amino acids and amines:Electron transport:Protein synthesis:tRNA and rRNA base modification:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridoxine:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino acid biosynthesis:Protein synthesis:Energy metabolism:Energy Metabolism:Pyridoxine:Aspartate family:tRNA and rRNA base modification:Electron transport:Amino acids and amines:Global:Metabolism:Metabolism:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Global:Metabolism:Xenobiotics Biodegradation and Metabolism" 217 "Molecular chaperone (small heat shock protein):Molecular chaperone (small heat shock protein):ABC-type dipeptide transport system, periplasmic component:ABC-type dipeptide transport system, periplasmic component:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized homolog of PSP1:Uncharacterized homolog of PSP1:Uncharacterized enzyme of thiazole biosynthesis:Uncharacterized enzyme of thiazole biosynthesis:Amino acid transport and metabolism:Amino acid transport and metabolism:recombinase activity:catalytic activity:ionotropic glutamate receptor activity:transporter activity:extracellular-glutamate-gated ion channel activity:binding:DNA recombination:transport:thiamine biosynthetic process:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Thiamine metabolism:Thiamine metabolism:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:HEQRo_perm_3TM:HEQRo_perm_3TM:tol_pal_ybgF:tol_pal_ybgF:Poorly characterized:Metabolism:Metabolism:Membrane Transport:Metabolism of Cofactors and Vitamins:Amino acids, peptides and amines:Global:Transport and binding proteins:Environmental Information Processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transport and binding proteins:Amino acids, peptides and amines:Cellular processes and signaling:Metabolism" 218 "Energy production and conversion:Energy production and conversion:Cysteine synthase:Cysteine synthase:Co-chaperonin GroES (HSP10):Co-chaperonin GroES (HSP10):Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Molecular chaperone, HSP90 family:Molecular chaperone, HSP90 family:Molecular chaperone:Molecular chaperone:Chaperonin GroEL (HSP60 family):Chaperonin GroEL (HSP60 family):Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:Molecular chaperone GrpE (heat shock protein):Molecular chaperone GrpE (heat shock protein):Preprotein translocase subunit SecA (ATPase, RNA helicase):Preprotein translocase subunit SecA (ATPase, RNA helicase):NifU homolog involved in Fe-S cluster formation:NifU homolog involved in Fe-S cluster formation:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):adenyl-nucleotide exchange factor activity:nucleic acid binding:chaperonin ATPase activity:catalytic activity:cysteine synthase activity:cysteine-type endopeptidase activity:serine-type endopeptidase activity:helicase activity:iron ion binding:protein binding:ATP binding:electron transport:regulation of transcription, DNA-dependent:protein folding:proteolysis:cysteine biosynthetic process from serine:protein targeting:chemotaxis:metabolic process:protein-glutamate methylesterase activity:electron carrier activity:iron-sulfur cluster assembly:protein import:pyridoxal phosphate binding:2-alkenal reductase [NAD(P)] activity:protein homodimerization activity:cellular protein metabolic process:unfolded protein binding:chaperone binding:iron-sulfur cluster binding:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Selenocompound metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:RNA degradation:RNA degradation:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:secA:secA:cysKM:cysKM:NifU_proper:NifU_proper:degP_htrA_DO:degP_htrA_DO:GroEL:GroEL:prok_dnaK:prok_dnaK:rSAM_NirJ1:rSAM_NirJ1:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Central intermediary metabolism:Nitrogen fixation:Protein fate:Protein folding and stabilization:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Amino acid biosynthesis:Serine family:Cellular processes and signaling:Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:Nitrogen fixation:Protein folding and stabilization:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Serine family:Central intermediary metabolism:Protein fate:Amino acid biosynthesis:Cell Motility:Signal Transduction:Membrane Transport:Folding Sorting and Degradation:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Other Amino Acids:Amino Acid Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global" 219 "Acetyltransferases:Acetyltransferases:UDP-3-O-acyl-N-acetylglucosamine deacetylase:UDP-3-O-acyl-N-acetylglucosamine deacetylase:Predicted transcriptional regulator:Predicted transcriptional regulator:FOG: GGDEF domain:FOG: GGDEF domain:Transposase and inactivated derivatives:Transposase and inactivated derivatives:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:transposase activity:nucleobase-containing compound metabolic process:DNA recombination:transposition, DNA-mediated:regulation of transcription, DNA-dependent:N-terminal protein amino acid acetylation:3'-5' exonuclease activity:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity:ribosomal-protein-alanine N-acetyltransferase activity:cyclic nucleotide biosynthetic process:lipid A biosynthetic process:DNA integration:phosphorus-oxygen lyase activity:intracellular signal transduction:ribosome biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Metabolic pathways:Metabolic pathways:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:GGDEF:GGDEF:lpxC:lpxC:rrf2_super:rrf2_super:rimI:rimI:Poorly characterized:Glycan Biosynthesis and Metabolism:Metabolism:Metabolism:Global:Ribosomal proteins: synthesis and modification:General:Other:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Protein synthesis:Unknown function:Signal transduction:Cell envelope:Information storage and processing:Cellular processes and signaling:Poorly characterized:Metabolism:Glycan Biosynthesis and Metabolism:Global:Metabolism:Protein synthesis:Ribosomal proteins: synthesis and modification:Unknown function:General:Signal transduction:Other:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling" 220 "Energy production and conversion:Energy production and conversion:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Argininosuccinate synthase:Argininosuccinate synthase:Argininosuccinate lyase:Argininosuccinate lyase:Fe-S oxidoreductase:Fe-S oxidoreductase:FAD/FMN-containing dehydrogenases:FAD/FMN-containing dehydrogenases:Acetate kinase:Acetate kinase:Recombinational DNA repair protein (RecF pathway):Recombinational DNA repair protein (RecF pathway):Aspartokinases:Aspartokinases:tRNA nucleotidyltransferase/poly(A) polymerase:tRNA nucleotidyltransferase/poly(A) polymerase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:BioD-like N-terminal domain of phosphotransacetylase:BioD-like N-terminal domain of phosphotransacetylase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Uncharacterized conserved protein containing a ferredoxin-like domain:Uncharacterized conserved protein containing a ferredoxin-like domain:L-lactate permease:L-lactate permease:Amino acid transport and metabolism:Amino acid transport and metabolism:nucleic acid binding:RNA binding:IMP cyclohydrolase activity:argininosuccinate synthase activity:argininosuccinate lyase activity:aspartate kinase activity:branched-chain-amino-acid transaminase activity:phosphoribosylaminoimidazolecarboxamide formyltransferase activity:iron ion binding:ATP binding:organic acid metabolic process:acetyl-CoA biosynthetic process from pyruvate:fermentation:electron transport:purine nucleotide biosynthetic process:DNA repair:DNA recombination:RNA processing:arginine biosynthetic process:metabolic process:zinc ion binding:cellular amino acid biosynthetic process:acetate kinase activity:glycolate oxidase activity:phosphate acetyltransferase activity:electron carrier activity:branched chain family amino acid metabolic process:branched chain family amino acid biosynthetic process:cobalamin biosynthetic process:folic acid-containing compound biosynthetic process:lactate transmembrane transporter activity:lactate transport:phosphorylation:amino acid binding:nucleotidyltransferase activity:hydrolase activity:pyruvate synthase activity:manganese ion binding:5-formyltetrahydrofolate cyclo-ligase activity:thiamine pyrophosphate binding:cobyrinic acid a,c-diamide synthase activity:arginine biosynthetic process via ornithine:2-oxoglutarate synthase activity:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Taurine and hypotaurine metabolism:Taurine and hypotaurine metabolism:Pyruvate metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Propanoate metabolism:Methane metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Function unknown:Function unknown:ackA:ackA:argG:argG:DNA_YbaB_EbfC:DNA_YbaB_EbfC:recR:recR:pta:pta:asp_kin_monofn:asp_kin_monofn:lctP:lctP:argH:argH:ilvE_I:ilvE_I:pyruv_ox_red:pyruv_ox_red:Fermentation:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Unknown function:General:Amino acid biosynthesis:Metabolism:Glutamate family:Pyruvate family:Information storage and processing:Metabolism:Poorly characterized:Global:Genetic Information Processing:Metabolism:Metabolism:Replication and Repair:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Aspartate family:Carbohydrate Metabolism:Poorly characterized:Metabolism:Information storage and processing:Energy Metabolism:Amino Acid Metabolism:Amino acid biosynthesis:Unknown function:Transport and binding proteins:DNA metabolism:Energy metabolism:Pyruvate family:Glutamate family:Metabolism of Other Amino Acids:Aspartate family:Metabolism of Cofactors and Vitamins:General:Genetic Information Processing:Replication and Repair:Global:Metabolism:Carbohydrates, organic alcohols, and acids:DNA replication, recombination, and repair:Fermentation:Energy metabolism" 221 "Preprotein translocase subunit SecY:Preprotein translocase subunit SecY:ATPase components of ABC transporters with duplicated ATPase domains:ATPase components of ABC transporters with duplicated ATPase domains:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:rRNA methylases:rRNA methylases:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Periplasmic component of the Tol biopolymer transport system:Periplasmic component of the Tol biopolymer transport system:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ADP-ribose pyrophosphatase:ADP-ribose pyrophosphatase:Na+/H+ antiporter NhaD and related arsenite permeases:Na+/H+ antiporter NhaD and related arsenite permeases:Uncharacterized ABC-type transport system, permease component:Uncharacterized ABC-type transport system, permease component:Type II secretory pathway, component PulF:Type II secretory pathway, component PulF:Ribonucleases G and E:Ribonucleases G and E:Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein:Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein:Antitoxin of toxin-antitoxin stability system:Antitoxin of toxin-antitoxin stability system:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:ABC-type uncharacterized transport systems, ATPase components:ABC-type uncharacterized transport systems, ATPase components:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:xanthine phosphoribosyltransferase activity:RNA binding:catalytic activity:ribonuclease activity:ionotropic glutamate receptor activity:transporter activity:extracellular-glutamate-gated ion channel activity:ATP binding:mismatch repair:RNA processing:cellular aromatic compound metabolic process:transport:lipid binding:protein transporter activity:tRNA (guanosine-2'-O-)-methyltransferase activity:nucleoside metabolic process:protein secretion:RNA modification:protein transport:citrate transmembrane transporter activity:monosaccharide-transporting ATPase activity:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:protein secretion by the type II secretion system:citrate transport:hydrolase activity:ATPase activity:carbohydrate binding:mismatched DNA binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Purine metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:RNA degradation:RNA degradation:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:RNaseEG:RNaseEG:3a0501s007:3a0501s007:phd_fam:phd_fam:propeller_TolB:propeller_TolB:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Pathogenesis:Protein and peptide secretion and trafficking:Degradation of RNA:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Folding Sorting and Degradation:Nucleotide Metabolism:Mobile and extrachromosomal element functions:Poorly characterized:Protein fate:Transcription:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transcription:Degradation of RNA:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Pathogenesis:Mobile and extrachromosomal element functions:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Cellular processes" 222 "Thioredoxin reductase:Thioredoxin reductase:Predicted permeases:Predicted permeases:ABC-type antimicrobial peptide transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:Pyruvate-formate lyase-activating enzyme:Pyruvate-formate lyase-activating enzyme:Predicted glycosyltransferases:Predicted glycosyltransferases:Flagellar motor protein:Flagellar motor protein:Aspartyl aminopeptidase:Aspartyl aminopeptidase:FOG: PAS/PAC domain:FOG: PAS/PAC domain:ABC-type transport system, involved in lipoprotein release, permease component:ABC-type transport system, involved in lipoprotein release, permease component:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):nucleotide binding:aminopeptidase I activity:thioredoxin-disulfide reductase activity:ATP binding:glucose metabolic process:electron transport:regulation of transcription, DNA-dependent:proteolysis:oxygen and reactive oxygen species metabolic process:electron carrier activity:cyclic nucleotide biosynthetic process:thiamine biosynthetic process:phosphorus-oxygen lyase activity:ATPase activity:removal of superoxide radicals:intracellular signal transduction:aspartyl aminopeptidase activity:[formate-C-acetyltransferase]-activating enzyme activity:4 iron, 4 sulfur cluster binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Pyrimidine metabolism:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:PFLE_PFLC:PFLE_PFLC:Defense mechanisms:Defense mechanisms:Metabolism:Cell Motility:Metabolism:Cellular processes and signaling:Regulatory functions:Small molecule interactions:Cellular Processes:Metabolism:Cell Motility:Nucleotide Metabolism:Poorly characterized:Cellular Processes:Regulatory functions:Small molecule interactions:Cellular processes and signaling:Metabolism:Poorly characterized:Nucleotide Metabolism" 223 "Energy production and conversion:Energy production and conversion:Glutamyl- and glutaminyl-tRNA synthetases:Glutamyl- and glutaminyl-tRNA synthetases:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Histidinol dehydrogenase:Histidinol dehydrogenase:Methionyl-tRNA synthetase:Methionyl-tRNA synthetase:Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase:Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:Fe-S oxidoreductase:Fe-S oxidoreductase:Malic enzyme:Malic enzyme:Queuine/archaeosine tRNA-ribosyltransferase:Queuine/archaeosine tRNA-ribosyltransferase:Predicted membrane protein:Predicted membrane protein:Glycosyltransferase:Glycosyltransferase:Topoisomerase IA:Topoisomerase IA:Predicted phosphoesterase:Predicted phosphoesterase:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Nitroreductase:Nitroreductase:Formyltetrahydrofolate hydrolase:Formyltetrahydrofolate hydrolase:Na+/alanine symporter:Na+/alanine symporter:Predicted kinase related to dihydroxyacetone kinase:Predicted kinase related to dihydroxyacetone kinase:Uncharacterized conserved protein:Uncharacterized conserved protein:Na+/H+ antiporter:Na+/H+ antiporter:Predicted hydrolases of HD superfamily:Predicted hydrolases of HD superfamily:Uncharacterized conserved protein:Uncharacterized conserved protein:Zn-dependent proteases:Zn-dependent proteases:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:tRNA binding:histidine biosynthetic process:DNA topoisomerase type I activity:GTP cyclohydrolase I activity:metalloendopeptidase activity:glycerol-3-phosphate O-acyltransferase activity:glycerone kinase activity:histidinol dehydrogenase activity:histidinol-phosphate transaminase activity:malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity:methenyltetrahydrofolate cyclohydrolase activity:methylenetetrahydrofolate dehydrogenase (NADP+) activity:phosphatidylserine decarboxylase activity:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity:glutamate-tRNA ligase activity:glutamine-tRNA ligase activity:methionine-tRNA ligase activity:urate oxidase activity:sodium:amino acid symporter activity:binding:ATP binding:glycerol metabolic process:electron transport:purine base metabolic process:purine nucleotide biosynthetic process:'de novo' IMP biosynthetic process:DNA topological change:DNA unwinding involved in replication:DNA modification:tRNA modification:glutamyl-tRNA aminoacylation:glutaminyl-tRNA aminoacylation:methionyl-tRNA aminoacylation:proteolysis:sulfur compound metabolic process:sodium ion transport:tRNA processing:metallopeptidase activity:5'-nucleotidase activity:zinc ion binding:queuine tRNA-ribosyltransferase activity:queuosine biosynthetic process:formyltetrahydrofolate deformylase activity:succinyl-diaminopimelate desuccinylase activity:electron carrier activity:biosynthetic process:lysine biosynthetic process:thiamine biosynthetic process:folic acid-containing compound biosynthetic process:amino acid transmembrane transporter activity:amino acid binding:hydroxymethyl-, formyl- and related transferase activity:hydrolase activity:IMP-GMP specific 5'-nucleotidase activity:L-malate dehydrogenase activity:pyridoxal phosphate binding:metal ion binding:protein dimerization activity:NAD binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Purine metabolism:Purine metabolism:Lysine biosynthesis:Lysine biosynthesis:Histidine metabolism:Histidine metabolism:Tyrosine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Novobiocin biosynthesis:Selenocompound metabolism:Selenocompound metabolism:Glycerolipid metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Pyruvate metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:One carbon pool by folate:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Function unknown:Function unknown:TIGR00023:TIGR00023:yfcE:yfcE:hisD:hisD:purC:purC:metG:metG:Q_tRNA_tgt:Q_tRNA_tgt:gltX_bact:gltX_bact:PurU:PurU:TIGR00702:TIGR00702:DegV:DegV:agcS:agcS:topA_bact:topA_bact:hisC:hisC:queuosine_YadB:queuosine_YadB:Purine ribonucleotide biosynthesis:Translation:Metabolism:Metabolism:Genetic Information Processing:Global:Biosynthesis:Purine ribonucleotide biosynthesis:DNA replication, recombination, and repair:tRNA aminoacylation:tRNA and rRNA base modification:Conserved:Enzymes of unknown specificity:General:Histidine family:Fatty acid and phospholipid metabolism:Purines, pyrimidines, nucleosides, and nucleotides:DNA metabolism:Protein synthesis:Hypothetical proteins:Unknown function:Amino acid biosynthesis:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Biosynthesis of Other Secondary Metabolites:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Histidine family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins" 224 "Acetyltransferase (isoleucine patch superfamily):Acetyltransferase (isoleucine patch superfamily):Prolipoprotein diacylglyceryltransferase:Prolipoprotein diacylglyceryltransferase:Uncharacterized membrane protein, possible Na+ channel or pump:Uncharacterized membrane protein, possible Na+ channel or pump:Predicted transcriptional regulator:Predicted transcriptional regulator:DNA binding:calcium ion binding:regulation of transcription, DNA-dependent:zinc ion binding:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity:protein lipoylation:transferase activity:transferase activity, transferring acyl groups:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:General function prediction only:General function prediction only:lgt:lgt:Information storage and processing:Cellular processes and signaling:Poorly characterized:Poorly characterized:Protein fate:Protein modification and repair:Information storage and processing:Protein fate:Cellular processes and signaling:Protein modification and repair" 225 "Thiamine monophosphate synthase:Thiamine monophosphate synthase:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Transcriptional regulator:Transcriptional regulator:Signal transduction histidine kinase:Signal transduction histidine kinase:Alanine racemase:Alanine racemase:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Predicted glycosyltransferases:Predicted glycosyltransferases:Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain:Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain:Uncharacterized protein involved in formate dehydrogenase formation:Uncharacterized protein involved in formate dehydrogenase formation:Signal transduction histidine kinase regulating citrate/malate metabolism:Signal transduction histidine kinase regulating citrate/malate metabolism:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:sequence-specific DNA binding transcription factor activity:acetate-CoA ligase activity:thiamine-phosphate diphosphorylase activity:ATP binding:regulation of transcription, DNA-dependent:alanine metabolic process:signal transduction:metabolic process:alanine racemase activity:thiamine biosynthetic process:AMP binding:ligase activity, forming carbon-sulfur bonds:peptidyl-histidine phosphorylation:isopentenyl diphosphate biosynthetic process, mevalonate pathway:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:D-Alanine metabolism:D-Alanine metabolism:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Methane metabolism:Methane metabolism:Thiamine metabolism:Thiamine metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:alr:alr:thiE:thiE:Ac_CoA_lig_AcsA:Ac_CoA_lig_AcsA:Poorly characterized:Regulatory functions:Regulatory functions:Small molecule interactions:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Other Amino Acids:Energy Metabolism:Metabolism:Carbohydrate Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of murein sacculus and peptidoglycan:Metabolism of Cofactors and Vitamins:Metabolism:Metabolism:Global:Small molecule interactions:Thiamine:Cell envelope:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Energy Metabolism:Global:Metabolism:Carbohydrate Metabolism:Metabolism" 226 "Nucleoside diphosphate kinase:Nucleoside diphosphate kinase:Predicted methyltransferases:Predicted methyltransferases:Uncharacterized conserved protein:Uncharacterized conserved protein:Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family:Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family:Predicted transcriptional regulators:Predicted transcriptional regulators:Predicted permeases:Predicted permeases:1-deoxy-D-xylulose 5-phosphate reductoisomerase:1-deoxy-D-xylulose 5-phosphate reductoisomerase:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:Transcription elongation factor:Transcription elongation factor:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Transcriptional regulators:Transcriptional regulators:DNA-directed RNA polymerase, subunit K/omega:DNA-directed RNA polymerase, subunit K/omega:Transcriptional regulators:Transcriptional regulators:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Putative Zn-dependent protease, contains TPR repeats:Putative Zn-dependent protease, contains TPR repeats:ATP-dependent protease HslVU (ClpYQ), peptidase subunit:ATP-dependent protease HslVU (ClpYQ), peptidase subunit:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:fatty-acyl-CoA binding:DNA binding:sequence-specific DNA binding transcription factor activity:transcription elongation regulator activity:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:metalloendopeptidase activity:threonine-type endopeptidase activity:nucleoside diphosphate kinase activity:transporter activity:binding:ATP binding:electron transport:GTP biosynthetic process:UTP biosynthetic process:CTP biosynthetic process:transcription, DNA-dependent:regulation of transcription, DNA-dependent:proteolysis:ubiquitin-dependent protein catabolic process:transport:signal transduction:metabolic process:methyltransferase activity:isoprenoid biosynthetic process:inositol monophosphate phosphatase activity:cobalamin biosynthetic process:oxidoreductase activity:regulation of fatty acid metabolic process:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity:cobyrinic acid a,c-diamide synthase activity:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Inositol phosphate metabolism:Inositol phosphate metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:RNA polymerase:RNA polymerase:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00096:TIGR00096:Dxr:Dxr:rpoZ:rpoZ:greA:greA:HEQRo_perm_3TM:HEQRo_perm_3TM:CxxC_CxxC_SSSS:CxxC_CxxC_SSSS:ATP_dep_HslV:ATP_dep_HslV:Poorly characterized:Signal Transduction:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Transcription:Signal Transduction:Cell Motility:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:DNA interactions:DNA-dependent RNA polymerase:Transcription factors:Degradation of proteins, peptides, and glycopeptides:Amino acids, peptides and amines:Enzymes of unknown specificity:Other:Regulatory functions:Transcription:Protein fate:Transport and binding proteins:Unknown function:Biosynthesis of cofactors, prosthetic groups, and carriers:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Transcription:Environmental Information Processing:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:DNA interactions:Transcription:DNA-dependent RNA polymerase:Transcription factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Amino acids, peptides and amines:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Cellular processes and signaling:Metabolism" 227 "Energy production and conversion:Energy production and conversion:Delta-aminolevulinic acid dehydratase:Delta-aminolevulinic acid dehydratase:Methionyl-tRNA formyltransferase:Methionyl-tRNA formyltransferase:N-formylmethionyl-tRNA deformylase:N-formylmethionyl-tRNA deformylase:DNA primase (bacterial type):DNA primase (bacterial type):ATP-dependent Lon protease, bacterial type:ATP-dependent Lon protease, bacterial type:DnaJ-class molecular chaperone with C-terminal Zn finger domain:DnaJ-class molecular chaperone with C-terminal Zn finger domain:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):Preprotein translocase subunit SecA (ATPase, RNA helicase):Preprotein translocase subunit SecA (ATPase, RNA helicase):Predicted membrane-associated Zn-dependent proteases 1:Predicted membrane-associated Zn-dependent proteases 1:Fe-S oxidoreductase:Fe-S oxidoreductase:Inactive homolog of metal-dependent proteases, putative molecular chaperone:Inactive homolog of metal-dependent proteases, putative molecular chaperone:ATP-dependent protease HslVU (ClpYQ), ATPase subunit:ATP-dependent protease HslVU (ClpYQ), ATPase subunit:Transcriptional regulators:Transcriptional regulators:DNA repair proteins:DNA repair proteins:Hydroxyethylthiazole kinase, sugar kinase family:Hydroxyethylthiazole kinase, sugar kinase family:Leucyl aminopeptidase (aminopeptidase T):Leucyl aminopeptidase (aminopeptidase T):Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Amino acid transport and metabolism:nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA primase activity:DNA-directed RNA polymerase activity:ATP-dependent peptidase activity:aminopeptidase activity:metalloendopeptidase activity:helicase activity:hydroxyethylthiazole kinase activity:methionyl-tRNA formyltransferase activity:porphobilinogen synthase activity:iron ion binding:protein binding:ATP binding:electron transport:pyrimidine nucleotide biosynthetic process:DNA replication, synthesis of RNA primer:DNA repair:DNA modification:transcription initiation, DNA-dependent:regulation of transcription, DNA-dependent:translation:methionyl-tRNA aminoacylation:protein folding:protein modification process:proteolysis:ATP-dependent proteolysis:protein targeting:metabolic process:zinc ion binding:O-sialoglycoprotein endopeptidase activity:endopeptidase Clp activity:formylmethionine deformylase activity:endopeptidase La activity:thiamine biosynthetic process:HslUV protease activity:response to heat:oxidoreductase activity:ATPase activity:sigma factor activity:protein import:nucleoside-triphosphatase activity:heat shock protein binding:phosphopantetheine binding:tetrapyrrole biosynthetic process:peptide deformylase activity:metal ion binding:flavin adenine dinucleotide binding:unfolded protein binding:iron-sulfur cluster binding:2 iron, 2 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:One carbon pool by folate:One carbon pool by folate:Thiamine metabolism:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:RNA polymerase:RNA polymerase:DNA replication:DNA replication:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Function unknown:Function unknown:TIGR00054:TIGR00054:pept_deformyl:pept_deformyl:hslU:hslU:fmt:fmt:radc:radc:thiM:thiM:lon:lon:secA:secA:dnaG:dnaG:DnaJ_bact:DnaJ_bact:RpoD_Cterm:RpoD_Cterm:IV_pilin_GFxxxE:IV_pilin_GFxxxE:bact_YeaZ:bact_YeaZ:sam_1_link_chp:sam_1_link_chp:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Folding Sorting and Degradation:Membrane Transport:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:DNA replication, recombination, and repair:Transcription factors:tRNA aminoacylation:Protein folding and stabilization:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Protein modification and repair:Thiamine:DNA metabolism:Transcription:Protein synthesis:Protein fate:Biosynthesis of cofactors, prosthetic groups, and carriers:Translation:Transcription:Metabolism of Cofactors and Vitamins:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein synthesis:tRNA aminoacylation:Protein fate:Protein folding and stabilization:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Protein modification and repair:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Replication and Repair" 228 "ATP phosphoribosyltransferase:ATP phosphoribosyltransferase:Glutamate synthase domain 2:Glutamate synthase domain 2:Nicotinate-nucleotide pyrophosphorylase:Nicotinate-nucleotide pyrophosphorylase:Uncharacterized conserved protein:Uncharacterized conserved protein:23S rRNA methylase:23S rRNA methylase:Glycosyltransferase:Glycosyltransferase:Topoisomerase IA:Topoisomerase IA:Signal recognition particle GTPase:Signal recognition particle GTPase:Shikimate kinase:Shikimate kinase:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:A/G-specific DNA glycosylase:A/G-specific DNA glycosylase:Predicted alternative thymidylate synthase:Predicted alternative thymidylate synthase:Predicted kinase related to dihydroxyacetone kinase:Predicted kinase related to dihydroxyacetone kinase:Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins:Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins:Uncharacterized bacitracin resistance protein:Uncharacterized bacitracin resistance protein:Long-chain fatty acid transport protein:Long-chain fatty acid transport protein:Permeases:Permeases:Holliday junction resolvasome, helicase subunit:Holliday junction resolvasome, helicase subunit:tRNA(1-methyladenosine) methyltransferase and related methyltransferases:tRNA(1-methyladenosine) methyltransferase and related methyltransferases:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:histidine biosynthetic process:rRNA modification:cell killing:DNA binding:ATP phosphoribosyltransferase activity:DNA topoisomerase type I activity:glutamate synthase (NADPH) activity:glycerone kinase activity:hypoxanthine phosphoribosyltransferase activity:nicotinate-nucleotide diphosphorylase (carboxylating) activity:endonuclease activity:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity:shikimate kinase activity:transporter activity:ATP binding:GTP binding:glycerol metabolic process:gluconeogenesis:dTMP biosynthetic process:DNA topological change:DNA unwinding involved in replication:DNA repair:base-excision repair:DNA modification:DNA recombination:glutamate biosynthetic process:SRP-dependent cotranslational protein targeting to membrane:transport:7S RNA binding:rRNA methyltransferase activity:crossover junction endodeoxyribonuclease activity:glucose-1-phosphate adenylyltransferase activity:undecaprenol kinase activity:biosynthetic process:four-way junction helicase activity:NAD biosynthetic process:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:glutamate synthase (NADH) activity:tRNA (adenine-N1-)-methyltransferase activity:nucleoside-triphosphatase activity:DNA N-glycosylase activity:fructose 1,6-bisphosphate 1-phosphatase activity:undecaprenyl-diphosphatase activity:flavin adenine dinucleotide binding:thymidylate synthase (FAD) activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Fructose and mannose metabolism:Fructose and mannose metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Histidine metabolism:Histidine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:One carbon pool by folate:One carbon pool by folate:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Base excision repair:Base excision repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Function unknown:Function unknown:ftsY:ftsY:hisG:hisG:nadC:nadC:glpX:glpX:ruvB:ruvB:undec_PP_bacA:undec_PP_bacA:DegV:DegV:TIGR01033:TIGR01033:topA_bact:topA_bact:mutY:mutY:thyX:thyX:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Poorly characterized:Amino Acid Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Translation:Folding Sorting and Degradation:Replication and Repair:Membrane Transport:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:Pentose phosphate pathway:2'-Deoxyribonucleotide metabolism:DNA interactions:DNA replication, recombination, and repair:Protein and peptide secretion and trafficking:General:Histidine family:Pyridine nucleotides:Biosynthesis and degradation of murein sacculus and peptidoglycan:Energy metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Regulatory functions:DNA metabolism:Protein fate:Unknown function:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Pentose phosphate pathway:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:Regulatory functions:DNA interactions:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking:Unknown function:General:Amino acid biosynthesis:Histidine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism" 229 "Energy production and conversion:Energy production and conversion:Enolase:Enolase:Fe-S oxidoreductase:Fe-S oxidoreductase:Phosphotransacetylase:Phosphotransacetylase:Hydrogenase maturation factor:Hydrogenase maturation factor:Ni,Fe-hydrogenase I large subunit:Ni,Fe-hydrogenase I large subunit:Uncharacterized flavoproteins:Uncharacterized flavoproteins:Ni,Fe-hydrogenase maturation factor:Ni,Fe-hydrogenase maturation factor:FOG: CheY-like receiver:FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Uncharacterized conserved protein containing a ferredoxin-like domain:Uncharacterized conserved protein containing a ferredoxin-like domain:6Fe-6S prismane cluster-containing protein:6Fe-6S prismane cluster-containing protein:Predicted Fe-S oxidoreductase:Predicted Fe-S oxidoreductase:Uncharacterized conserved protein:Uncharacterized conserved protein:Ni,Fe-hydrogenase I small subunit:Ni,Fe-hydrogenase I small subunit:Multiple antibiotic transporter:Multiple antibiotic transporter:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:FOG: GGDEF domain:FOG: GGDEF domain:Hemerythrin:Hemerythrin:Lysophospholipase L1 and related esterases:Lysophospholipase L1 and related esterases:Uncharacterized conserved protein:Uncharacterized conserved protein:Short-chain alcohol dehydrogenase of unknown specificity:Short-chain alcohol dehydrogenase of unknown specificity:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:catalytic activity:phosphopyruvate hydratase activity:signal transducer activity:binding:protein binding:ATP binding:glycolysis:fermentation:electron transport:mitochondrial electron transport, NADH to ubiquinone:transcription initiation, DNA-dependent:regulation of transcription, DNA-dependent:lipid metabolic process:chemotaxis:signal transduction:enzyme activator activity:NADH dehydrogenase (ubiquinone) activity:metabolic process:peptidase activity:glycolate oxidase activity:ferredoxin hydrogenase activity:phosphate acetyltransferase activity:electron carrier activity:cyclic nucleotide biosynthetic process:folic acid-containing compound biosynthetic process:FMN binding:nickel ion binding:protein processing:oxidoreductase activity:oxidoreductase activity, acting on other nitrogenous compounds as donors:transferase activity, transferring acyl groups other than amino-acyl groups:hydrolase activity:hydrolase activity, acting on ester bonds:phosphorus-oxygen lyase activity:sigma factor activity:5-formyltetrahydrofolate cyclo-ligase activity:hydrogenase (acceptor) activity:intracellular signal transduction:sequence-specific DNA binding:cellular metabolic process:cellular protein metabolic process:metal ion binding:coenzyme binding:iron-sulfur cluster binding:CoB--CoM heterodisulfide reductase activity:Transcription:Transcription:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Nitrotoluene degradation:Nitrotoluene degradation:Butanoate metabolism:Butanoate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:RNA degradation:RNA degradation:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:hydrog_prot:hydrog_prot:hypC_hupF:hypC_hupF:GGDEF:GGDEF:TIGR00273:TIGR00273:hydA:hydA:rlpA:rlpA:TIGR00427:TIGR00427:eno:eno:TIGR01212:TIGR01212:hybrid_clust:hybrid_clust:hemeryth_dom:hemeryth_dom:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Energy metabolism:Amino acids and amines:Electron transport:Glycolysis/gluconeogenesis:Protein fate:Protein modification and repair:Unknown function:Enzymes of unknown specificity:General:Signal transduction:Other:Cell envelope:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cell envelope:Signal transduction:Unknown function:Protein fate:Energy metabolism:Other:Other:General:Enzymes of unknown specificity:Carbohydrate Metabolism:Protein modification and repair:Glycolysis/gluconeogenesis:Electron transport:Amino acids and amines:Global:Cellular Processes:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Folding Sorting and Degradation:Xenobiotics Biodegradation and Metabolism:Energy Metabolism:Cellular Processes:Signal Transduction:Cell Motility:Environmental Information Processing:Global:Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Energy Metabolism:Carbohydrate Metabolism" 230 "Energy production and conversion:Energy production and conversion:Glutamate synthase domain 2:Glutamate synthase domain 2:Phosphoribosyl-AMP cyclohydrolase:Phosphoribosyl-AMP cyclohydrolase:Triosephosphate isomerase:Triosephosphate isomerase:Tyrosyl-tRNA synthetase:Tyrosyl-tRNA synthetase:Histidinol phosphatase and related phosphatases:Histidinol phosphatase and related phosphatases:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:ATPase components of ABC transporters with duplicated ATPase domains:ATPase components of ABC transporters with duplicated ATPase domains:Isocitrate dehydrogenases:Isocitrate dehydrogenases:Ribosomal protein S1:Ribosomal protein S1:Signal peptidase I:Signal peptidase I:Shikimate kinase:Shikimate kinase:Predicted permeases:Predicted permeases:Long-chain acyl-CoA synthetases (AMP-forming):Long-chain acyl-CoA synthetases (AMP-forming):3-deoxy-D-manno-octulosonic-acid transferase:3-deoxy-D-manno-octulosonic-acid transferase:Coenzyme F390 synthetase:Coenzyme F390 synthetase:Transcriptional regulators:Transcriptional regulators:ABC-type tungstate transport system, permease component:ABC-type tungstate transport system, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:fatty-acyl-CoA binding:histidine biosynthetic process:sequence-specific DNA binding transcription factor activity:RNA binding:structural constituent of ribosome:fatty-acyl-CoA synthase activity:glutamate synthase (NADPH) activity:histidinol-phosphatase activity:isocitrate dehydrogenase (NAD+) activity:isocitrate dehydrogenase (NADP+) activity:long-chain fatty acid-CoA ligase activity:phosphoribosyl-AMP cyclohydrolase activity:phosphoribosyl-ATP diphosphatase activity:shikimate kinase activity:triose-phosphate isomerase activity:tyrosine-tRNA ligase activity:transporter activity:ATP binding:sugar binding:carbohydrate metabolic process:glycolysis:tricarboxylic acid cycle:regulation of transcription, DNA-dependent:translation:tyrosyl-tRNA aminoacylation:proteolysis:cellular amino acid metabolic process:glutamate biosynthetic process:fatty acid metabolic process:transport:metabolic process:signal peptidase I activity:glutamate synthase (NADH) activity:transferase activity:ATPase activity:regulation of fatty acid metabolic process:short-chain fatty acid-CoA ligase activity:medium-chain fatty acid-CoA ligase activity:very long-chain fatty acid-CoA ligase activity:nucleoside-triphosphate diphosphatase activity:phenylacetate-CoA ligase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Fructose and mannose metabolism:Fructose and mannose metabolism:Fatty acid metabolism:Fatty acid metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Histidine metabolism:Histidine metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Glutathione metabolism:Glutathione metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Inositol phosphate metabolism:Inositol phosphate metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Ribosome:Ribosome:Protein export:Protein export:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:tyrS:tyrS:tim:tim:mazG:mazG:autotrans_barl:autotrans_barl:Histidinol-ppas:Histidinol-ppas:sigpep_I_bact:sigpep_I_bact:ABC_ABC_ChvD:ABC_ABC_ChvD:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Membrane Transport:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:Glycolysis/gluconeogenesis:tRNA aminoacylation:Protein and peptide secretion and trafficking:Pathogenesis:General:Energy metabolism:Protein synthesis:Protein fate:Cellular processes:Unknown function:Folding Sorting and Degradation:Translation:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Pathogenesis:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism" 231 "Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Uncharacterized ATPase, putative transposase:Uncharacterized ATPase, putative transposase:Mu-like prophage protein gp29:Mu-like prophage protein gp29:Mu-like prophage host-nuclease inhibitor protein Gam:Mu-like prophage host-nuclease inhibitor protein Gam:Mu-like prophage major head subunit gpT:Mu-like prophage major head subunit gpT:Mu-like prophage protein gp37:Mu-like prophage protein gp37:nucleotide binding:DNA binding:DNA integration:nucleoside-triphosphatase activity:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:General function prediction only:General function prediction only:Function unknown:Function unknown:Poorly characterized:Poorly characterized:Cellular processes and signaling:Cellular processes and signaling" 232 "Energy production and conversion:Energy production and conversion:Ketol-acid reductoisomerase:Ketol-acid reductoisomerase:Acetolactate synthase, small (regulatory) subunit:Acetolactate synthase, small (regulatory) subunit:Fe2+/Zn2+ uptake regulation proteins:Fe2+/Zn2+ uptake regulation proteins:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:RimM protein, required for 16S rRNA processing:RimM protein, required for 16S rRNA processing:Predicted hydrolase (HAD superfamily):Predicted hydrolase (HAD superfamily):Pyruvate carboxylase:Pyruvate carboxylase:Predicted inhibitor of MCP methylation, homolog of CheC:Predicted inhibitor of MCP methylation, homolog of CheC:Sec-independent protein secretion pathway components:Sec-independent protein secretion pathway components:Predicted RNA-binding protein (contains KH domain):Predicted RNA-binding protein (contains KH domain):Uncharacterized conserved protein:Uncharacterized conserved protein:ACT domain-containing protein:ACT domain-containing protein:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):nucleotide binding:DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:catalytic activity:acetolactate synthase activity:ketol-acid reductoisomerase activity:pyruvate carboxylase activity:ATP binding:gluconeogenesis:regulation of transcription, DNA-dependent:rRNA processing:metabolic process:branched chain family amino acid biosynthetic process:cyclic nucleotide biosynthetic process:protein secretion:biotin binding:protein transport:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:proton transport:amino acid binding:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances:phosphorus-oxygen lyase activity:metal ion transport:intracellular signal transduction:ribosome binding:metal ion binding:coenzyme binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Bacterial chemotaxis:Bacterial chemotaxis:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:acolac_sm:acolac_sm:sensory_box:sensory_box:ilvC:ilvC:tatAE:tatAE:16S_RimM:16S_RimM:DivI1A_domain:DivI1A_domain:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Carbohydrate Metabolism:Metabolism:Regulatory functions:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:Small molecule interactions:RNA processing:Protein and peptide secretion and trafficking:Pyruvate family:Regulatory functions:Transcription:Protein fate:Amino acid biosynthesis:Cell Motility:Membrane Transport:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Metabolism:Small molecule interactions:Transcription:RNA processing:Protein fate:Protein and peptide secretion and trafficking:Amino acid biosynthesis:Pyruvate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 233 "Restriction endonuclease S subunits:Restriction endonuclease S subunits:FOG: CheY-like receiver:FOG: CheY-like receiver:Transposase and inactivated derivatives:Transposase and inactivated derivatives:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:DNA modification:DNA methylation:regulation of transcription, DNA-dependent:methyltransferase activity:N-methyltransferase activity:Type I site-specific deoxyribonuclease activity:Type II site-specific deoxyribonuclease activity:DNA restriction-modification system:DNA integration:methylation:Replication, recombination and repair:Replication, recombination and repair:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Signal transduction mechanisms:Signal transduction mechanisms:Defense mechanisms:Defense mechanisms:Cellular processes and signaling:Cell Motility:Signal Transduction:Cellular Processes:Environmental Information Processing:Information storage and processing:Cellular processes and signaling:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Information storage and processing" 234 "Energy production and conversion:Energy production and conversion:DNA repair exonuclease:DNA repair exonuclease:Periplasmic protease:Periplasmic protease:Glucokinase:Glucokinase:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Cold shock proteins:Cold shock proteins:Predicted periplasmic solute-binding protein:Predicted periplasmic solute-binding protein:Predicted membrane protein:Predicted membrane protein:Arabinose efflux permease:Arabinose efflux permease:Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase:Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:glucokinase activity:transporter activity:binding:protein binding:ATP binding:carbohydrate metabolic process:glycolysis:electron transport:regulation of transcription, DNA-dependent:proteolysis:transport:response to oxidative stress:5'-nucleotidase activity:lipopolysaccharide biosynthetic process:response to salt stress:oxidoreductase activity:transferase activity, transferring hexosyl groups:hydrolase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:IMP-GMP specific 5'-nucleotidase activity:C-terminal processing peptidase activity:carbohydrate binding:lipid glycosylation:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Galactose metabolism:Galactose metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Function unknown:Function unknown:prc:prc:8TM_EpsH:8TM_EpsH:pepcterm_polyde:pepcterm_polyde:Carbohydrate Metabolism:Protein fate:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:Protein modification and repair:Protein and peptide secretion and trafficking:Global:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Biosynthesis of Other Secondary Metabolites:Global:Metabolism:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Biosynthesis of Other Secondary Metabolites" 235 "Arginyl-tRNA synthetase:Arginyl-tRNA synthetase:Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain:Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain:Ribosomal protein S12:Ribosomal protein S12:Ribosomal protein S7:Ribosomal protein S7:3-polyprenyl-4-hydroxybenzoate decarboxylase:3-polyprenyl-4-hydroxybenzoate decarboxylase:Transcription elongation factor:Transcription elongation factor:Protein chain release factor A:Protein chain release factor A:Translation initiation factor 1 (IF-1):Translation initiation factor 1 (IF-1):Translation elongation factors (GTPases):Translation elongation factors (GTPases):Superfamily II DNA and RNA helicases:Superfamily II DNA and RNA helicases:Translation initiation factor 2 (IF-2; GTPase):Translation initiation factor 2 (IF-2; GTPase):Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit:Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase):Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase):Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Predicted metal-dependent enzyme:Predicted metal-dependent enzyme:Peptide chain release factor RF-3:Peptide chain release factor RF-3:ABC-type proline/glycine betaine transport system, ATPase component:ABC-type proline/glycine betaine transport system, ATPase component:ABC-type proline/glycine betaine transport system, permease component:ABC-type proline/glycine betaine transport system, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:nucleotide binding:3'-5'-exoribonuclease activity:nucleic acid binding:sequence-specific DNA binding transcription factor activity:RNA binding:structural constituent of ribosome:translation initiation factor activity:translation elongation factor activity:GTPase activity:aminoacyl-tRNA hydrolase activity:phosphoribosylformylglycinamidine synthase activity:polyribonucleotide nucleotidyltransferase activity:arginine-tRNA ligase activity:protein binding:ATP binding:GTP binding:'de novo' IMP biosynthetic process:RNA processing:mRNA catabolic process:translation:translational initiation:translational elongation:translational termination:arginyl-tRNA aminoacylation:glutamyl-tRNA aminoacylation:regulation of translational fidelity:ubiquinone biosynthetic process:transport:amino acid transport:ATP-dependent helicase activity:protein-synthesizing GTPase activity:3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity:amino acid transmembrane transporter activity:quaternary-ammonium-compound-transporting ATPase activity:glycine betaine/proline porter activity:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:translation release factor activity, codon specific:hydrolase activity:carboxy-lyase activity:ATPase activity:regulation of transcription termination, DNA-dependent:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Ubiquinone and other terpenoid-quinone biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:One carbon pool by folate:One carbon pool by folate:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Ribosome:Ribosome:RNA degradation:RNA degradation:General function prediction only:General function prediction only:Function unknown:Function unknown:infA:infA:prfA:prfA:gatC:gatC:small_GTP:small_GTP:ubiX_pad:ubiX_pad:argS:argS:rpsL_bact:rpsL_bact:rpsG_bact:rpsG_bact:proV:proV:NusA:NusA:polynuc_phos:polynuc_phos:Unknown function:Transcription:Degradation of RNA:Transcription factors:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Translation factors:Transport and binding proteins:Amino acids, peptides and amines:Unknown function:Enzymes of unknown specificity:General:Information storage and processing:Metabolism:Poorly characterized:Transport and binding proteins:Protein synthesis:Transcription:General:Enzymes of unknown specificity:Amino acids, peptides and amines:Translation factors:Ribosomal proteins: synthesis and modification:Nucleotide Metabolism:tRNA aminoacylation:Transcription factors:Degradation of RNA:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Folding Sorting and Degradation:Translation:Metabolism of Cofactors and Vitamins:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Genetic Information Processing:Global:Metabolism:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Metabolism:Poorly characterized:Metabolism:Information storage and processing" 236 "Energy production and conversion:Energy production and conversion:Isopropylmalate/homocitrate/citramalate synthases:Isopropylmalate/homocitrate/citramalate synthases:Enolase:Enolase:Fructose/tagatose bisphosphate aldolase:Fructose/tagatose bisphosphate aldolase:Ribosome recycling factor:Ribosome recycling factor:Putative translation initiation inhibitor, yjgF family:Putative translation initiation inhibitor, yjgF family:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase:6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase:Uncharacterized NAD(FAD)-dependent dehydrogenases:Uncharacterized NAD(FAD)-dependent dehydrogenases:Nucleoside-diphosphate-sugar epimerases:Nucleoside-diphosphate-sugar epimerases:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase):S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase):Lactate dehydrogenase and related dehydrogenases:Lactate dehydrogenase and related dehydrogenases:Flagellin and related hook-associated proteins:Flagellin and related hook-associated proteins:Histidinol phosphatase and related hydrolases of the PHP family:Histidinol phosphatase and related hydrolases of the PHP family:Uncharacterized conserved protein:Uncharacterized conserved protein:Coenzyme F390 synthetase:Coenzyme F390 synthetase:Saccharopine dehydrogenase and related proteins:Saccharopine dehydrogenase and related proteins:ABC-type Co2+ transport system, periplasmic component:ABC-type Co2+ transport system, periplasmic component:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:histidine biosynthetic process:ciliary or flagellar motility:DNA binding:catalytic activity:DNA-directed DNA polymerase activity:GTPase activity:fructose-bisphosphate aldolase activity:glutamate synthase (NADPH) activity:histidinol-phosphatase activity:phosphoglycerate dehydrogenase activity:phosphopyruvate hydratase activity:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity:structural molecule activity:iron ion binding:ATP binding:glycolysis:pentose-phosphate shunt:electron transport:DNA replication:translation:anion transport:metabolic process:zinc ion binding:protein-synthesizing GTPase activity:queuosine biosynthetic process:S-adenosylmethionine-dependent methyltransferase activity:dTDP-4-dehydrorhamnose reductase activity:dihydrodipicolinate synthase activity:gluconate 2-dehydrogenase activity:tagatose-bisphosphate aldolase activity:electron carrier activity:lysine biosynthetic process:cobalamin biosynthetic process:protein disulfide oxidoreductase activity:glutamate synthase (NADH) activity:oxidoreductase activity:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen:6-phosphogluconolactonase activity:diaminopimelate biosynthetic process:carbohydrate binding:fructose 1,6-bisphosphate metabolic process:cobyrinic acid a,c-diamide synthase activity:'de novo' GDP-L-fucose biosynthetic process:extracellular polysaccharide biosynthetic process:cell redox homeostasis:phenylacetate-CoA ligase activity:GDP-L-fucose synthase activity:coenzyme binding:NAD binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Fructose and mannose metabolism:Fructose and mannose metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Lysine biosynthesis:Lysine biosynthesis:Histidine metabolism:Histidine metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Methane metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Flagellar assembly:Flagellar assembly:RNA degradation:RNA degradation:General function prediction only:General function prediction only:Function unknown:Function unknown:TIGR00004:TIGR00004:queA:queA:cbbA:cbbA:frr:frr:dapA:dapA:eno:eno:pgl:pgl:hisJ_fam:hisJ_fam:Transcription:Degradation of RNA:Protein synthesis:tRNA and rRNA base modification:Translation factors:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Carbohydrate Metabolism:Signal Transduction:Cell Motility:Metabolism:Metabolism:Amino acid biosynthesis:Environmental Information Processing:Protein synthesis:Transcription:Energy metabolism:Aspartate family:Translation factors:tRNA and rRNA base modification:Degradation of RNA:Pentose phosphate pathway:Glycolysis/gluconeogenesis:Global:Cellular Processes:Carbohydrate Metabolism:Energy Metabolism:Metabolism:Amino Acid Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Genetic Information Processing:Global:Metabolism:Energy Metabolism:Amino Acid Metabolism:Folding Sorting and Degradation:Energy metabolism:Glycolysis/gluconeogenesis:Pentose phosphate pathway" 237 "Preprotein translocase subunit SecF:Preprotein translocase subunit SecF:Preprotein translocase subunit SecD:Preprotein translocase subunit SecD:Metal-dependent proteases with possible chaperone activity:Metal-dependent proteases with possible chaperone activity:Preprotein translocase subunit SecE:Preprotein translocase subunit SecE:Preprotein translocase subunit YidC:Preprotein translocase subunit YidC:Uncharacterized conserved protein:Uncharacterized conserved protein:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:N-acetylglutamate synthase and related acetyltransferases:N-acetylglutamate synthase and related acetyltransferases:Predicted periplasmic solute-binding protein:Predicted periplasmic solute-binding protein:Amino acid transport and metabolism:Amino acid transport and metabolism:acetyl-CoA:L-glutamate N-acetyltransferase activity:ribonuclease P activity:ATP binding:RNA processing:proteolysis:protein targeting:intracellular protein transport:tRNA processing:metabolic process:zinc ion binding:O-sialoglycoprotein endopeptidase activity:4-amino-4-deoxychorismate lyase activity:protein secretion:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:protein secretion by the type II secretion system:ATPase activity:protein insertion into membrane:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Arginine and proline metabolism:Arginine and proline metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Function unknown:Function unknown:rnpA:rnpA:TIGR00247:TIGR00247:TIGR00278:TIGR00278:gcp_kae1:gcp_kae1:2A0604s01:2A0604s01:secE_bact:secE_bact:3a0501s07:3a0501s07:yidC_oxa1_cterm:yidC_oxa1_cterm:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Poorly characterized:Metabolism:Cellular processes and signaling:Hypothetical proteins:Protein fate:Transcription:Transcription:RNA processing:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Hypothetical proteins:Conserved:Cellular processes and signaling:Metabolism:Poorly characterized:Conserved:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking:RNA processing:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Folding Sorting and Degradation:Membrane Transport:Folding Sorting and Degradation:Amino Acid Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Membrane Transport:Amino Acid Metabolism:Metabolism:Global:Metabolism" 238 "Formamidopyrimidine-DNA glycosylase:Formamidopyrimidine-DNA glycosylase:Permeases of the drug/metabolite transporter (DMT) superfamily:Permeases of the drug/metabolite transporter (DMT) superfamily:Uncharacterized membrane protein, putative virulence factor:Uncharacterized membrane protein, putative virulence factor:Diacylglycerol kinase:Diacylglycerol kinase:Membrane-fusion protein:Membrane-fusion protein:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities:Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities:Asparaginase:Asparaginase:TRAP-type C4-dicarboxylate transport system, periplasmic component:TRAP-type C4-dicarboxylate transport system, periplasmic component:Predicted membrane-associated, metal-dependent hydrolase:Predicted membrane-associated, metal-dependent hydrolase:FOG: EAL domain:FOG: EAL domain:Predicted ATPase:Predicted ATPase:TRAP-type C4-dicarboxylate transport system, small permease component:TRAP-type C4-dicarboxylate transport system, small permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:damaged DNA binding:asparaginase activity:biotin synthase activity:cystathionine beta-lyase activity:diacylglycerol kinase activity:iron ion binding:base-excision repair:nucleotide-excision repair:glycoprotein catabolic process:transport:metabolic process:zinc ion binding:sulfuric ester hydrolase activity:oxidized purine base lesion DNA N-glycosylase activity:protein transporter activity:phospholipid biosynthetic process:beta-aspartyl-peptidase activity:biosynthetic process:biotin biosynthetic process:thiamine biosynthetic process:protein secretion:pathogenesis:transferase activity, transferring nitrogenous groups:pyridoxal phosphate binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Selenocompound metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Glycerolipid metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Thiamine metabolism:Thiamine metabolism:Nitrogen metabolism:Nitrogen metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Base excision repair:Base excision repair:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:fpg:fpg:dctP:dctP:RND_mfp:RND_mfp:thiH:thiH:tRNA_sel_U_synt:tRNA_sel_U_synt:Glycan Biosynthesis and Metabolism:Transport and binding proteins:Metabolism of Cofactors and Vitamins:Protein synthesis:Genetic Information Processing:Replication and Repair:DNA metabolism:Environmental Information Processing:Signal Transduction:Thiamine:Global:Metabolism:Carbohydrates, organic alcohols, and acids:Unknown substrate:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Unknown substrate:Carbohydrates, organic alcohols, and acids:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:tRNA and rRNA base modification:DNA replication, recombination, and repair:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Signal Transduction:Replication and Repair:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Energy Metabolism:Lipid Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism:Poorly characterized:Lipid Metabolism:Metabolism:Cellular processes and signaling:Amino Acid Metabolism:Information storage and processing:Metabolism of Other Amino Acids:Biosynthesis of cofactors, prosthetic groups, and carriers" 239 "Phosphate uptake regulator:Phosphate uptake regulator:Predicted exonuclease of the beta-lactamase fold involved in RNA processing:Predicted exonuclease of the beta-lactamase fold involved in RNA processing:Uncharacterized protein, homolog of phage Mu protein gp30:Uncharacterized protein, homolog of phage Mu protein gp30:Uncharacterized homolog of phage Mu protein gp47:Uncharacterized homolog of phage Mu protein gp47:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Mu-like prophage tail sheath protein gpL:Mu-like prophage tail sheath protein gpL:Mu-like prophage protein gpG:Mu-like prophage protein gpG:two-component sensor activity:two-component signal transduction system (phosphorelay):nucleotide binding:DNA binding:ATP binding:regulation of transcription, DNA-dependent:Type II site-specific deoxyribonuclease activity:DNA restriction-modification system:hydrolase activity:peptidyl-histidine phosphorylation:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:tail_comp_S:tail_comp_S:phageSPP1_gp7:phageSPP1_gp7:excise:excise:phoU_full:phoU_full:Cell Motility:Anions:Regulatory functions:Small molecule interactions:Transport and binding proteins:Anions:Mobile and extrachromosomal element functions:Prophage functions:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Small molecule interactions:Cellular Processes:Environmental Information Processing:Cell Motility:Signal Transduction:Mobile and extrachromosomal element functions:Unknown function:Transport and binding proteins:Regulatory functions:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Signal Transduction:Prophage functions:Cellular Processes" 240 "Predicted ATPase with chaperone activity:Predicted ATPase with chaperone activity:DNA binding:ATP binding:DNA-dependent DNA replication initiation:DNA-dependent ATPase activity:photosynthesis:chlorophyll biosynthetic process:magnesium chelatase activity:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:TIGR00368:TIGR00368:General:Unknown function:General:Cellular processes and signaling:Unknown function:Cellular processes and signaling" 241 "Energy production and conversion:Energy production and conversion:Polyprenyltransferase (cytochrome oxidase assembly factor):Polyprenyltransferase (cytochrome oxidase assembly factor):ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Heme/copper-type cytochrome/quinol oxidase, subunit 3:Heme/copper-type cytochrome/quinol oxidase, subunit 3:Type II secretory pathway, prepilin signal peptidase PulO and related peptidases:Type II secretory pathway, prepilin signal peptidase PulO and related peptidases:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:cytochrome-c oxidase activity:hydrolase activity, hydrolyzing O-glycosyl compounds:signal transducer activity:transporter activity:carbohydrate metabolic process:electron transport:regulation of transcription, DNA-dependent:heme biosynthetic process:transport:chemotaxis:signal transduction:protoheme IX farnesyltransferase activity:prepilin peptidase activity:aa3-type cytochrome c oxidase:ba3-type cytochrome c oxidase:caa3-type cytochrome c oxidase:cbb3-type cytochrome c oxidase:metal ion binding:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Oxidative phosphorylation:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Signal transduction mechanisms:Signal transduction mechanisms:caa3_sub_IV:caa3_sub_IV:hemeryth_dom:hemeryth_dom:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Signal Transduction:Cellular Processes:Cell Motility:Energy metabolism:Global:Metabolism:Electron transport:Global:Metabolism:Metabolism:Energy metabolism:Electron transport:Cellular processes and signaling:Metabolism:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Metabolism of Cofactors and Vitamins:Energy Metabolism:Energy Metabolism:Cellular processes and signaling:Metabolism of Cofactors and Vitamins:Environmental Information Processing" 242 "Energy production and conversion:Energy production and conversion:Fe-S oxidoreductase:Fe-S oxidoreductase:Molybdopterin biosynthesis enzyme:Molybdopterin biosynthesis enzyme:Fructose-2,6-bisphosphatase:Fructose-2,6-bisphosphatase:SAM-dependent methyltransferases:SAM-dependent methyltransferases:FOG: CBS domain:FOG: CBS domain:Uncharacterized conserved protein:Uncharacterized conserved protein:Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs:Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs:Coenzyme F390 synthetase:Coenzyme F390 synthetase:Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:N-terminal domain of molybdenum-binding protein:N-terminal domain of molybdenum-binding protein:Uncharacterized MobA-related protein:Uncharacterized MobA-related protein:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:catalytic activity:electron transport:regulation of transcription, DNA-dependent:Mo-molybdopterin cofactor biosynthetic process:tRNA processing:metabolic process:methyltransferase activity:lipid biosynthetic process:cyclopropane-fatty-acyl-phospholipid synthase activity:electron carrier activity:cyclic nucleotide biosynthetic process:amino acid binding:phosphorus-oxygen lyase activity:intracellular signal transduction:metal ion binding:flavin adenine dinucleotide binding:iron-sulfur cluster binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:Cellular processes and signaling:Small molecule interactions:Regulatory functions:Poorly characterized:Metabolism:Cellular processes and signaling:Poorly characterized:Metabolism:Regulatory functions:Small molecule interactions" 243 "Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Signal transduction histidine kinase:Signal transduction histidine kinase:Predicted exonuclease of the beta-lactamase fold involved in RNA processing:Predicted exonuclease of the beta-lactamase fold involved in RNA processing:Membrane transporters of cations and cationic drugs:Membrane transporters of cations and cationic drugs:Flp pilus assembly protein, ATPase CpaF:Flp pilus assembly protein, ATPase CpaF:Amino acid transport and metabolism:Amino acid transport and metabolism:protein histidine kinase activity:ATP binding:GTP binding:transport:microtubule-based process:biosynthetic process:transferase activity, transferring nitrogenous groups:hydrolase activity:peptidyl-histidine phosphorylation:pyridoxal phosphate binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Signal transduction mechanisms:Signal transduction mechanisms:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Information storage and processing" 244 "Energy production and conversion:Energy production and conversion:Type I restriction-modification system methyltransferase subunit:Type I restriction-modification system methyltransferase subunit:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Predicted GTPase:Predicted GTPase:DNA modification methylase:DNA modification methylase:Na+/H+ antiporter:Na+/H+ antiporter:Uncharacterized membrane protein, possible Na+ channel or pump:Uncharacterized membrane protein, possible Na+ channel or pump:Uncharacterized conserved protein:Uncharacterized conserved protein:1-aminocyclopropane-1-carboxylate deaminase:1-aminocyclopropane-1-carboxylate deaminase:Predicted flavin-nucleotide-binding protein:Predicted flavin-nucleotide-binding protein:Virulence protein:Virulence protein:Amino acid transport and metabolism:Amino acid transport and metabolism:DNA binding:acetate-CoA ligase activity:GTP binding:DNA methylation:sodium ion transport:regulation of pH:metabolic process:N-methyltransferase activity:1-aminocyclopropane-1-carboxylate deaminase activity:site-specific DNA-methyltransferase (adenine-specific) activity:peptidoglycan biosynthetic process:FMN binding:sodium:hydrogen antiporter activity:transferase activity, transferring pentosyl groups:D-cysteine desulfhydrase activity:pyridoxal phosphate binding:Lipid transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Function unknown:Function unknown:hsdM:hsdM:ACC_deam_rel:ACC_deam_rel:mono_pep_trsgly:mono_pep_trsgly:Obg_CgtA:Obg_CgtA:Defense mechanisms:Defense mechanisms:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Carbohydrate Metabolism:DNA metabolism:Restriction/modification:Protein synthesis:Other:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cell envelope:Protein synthesis:DNA metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Other:Restriction/modification:Global:Metabolism:Metabolism:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Energy Metabolism:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Glycan Biosynthesis and Metabolism:Metabolism:Global:Metabolism" 245 "Energy production and conversion:Energy production and conversion:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Nucleoside-diphosphate-sugar epimerases:Nucleoside-diphosphate-sugar epimerases:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:MinD superfamily P-loop ATPase containing an inserted ferredoxin domain:MinD superfamily P-loop ATPase containing an inserted ferredoxin domain:Predicted signal transduction protein:Predicted signal transduction protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:catalytic activity:UDP-glucose 4-epimerase activity:transporter activity:electron transport:transport:metabolic process:dTDP-glucose 4,6-dehydratase activity:transaminase activity:electron carrier activity:cobalamin biosynthetic process:pyridoxal phosphate binding:cobyrinic acid a,c-diamide synthase activity:sequence-specific DNA binding:cellular metabolic process:coenzyme binding:iron-sulfur cluster binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Polyketide sugar unit biosynthesis:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Signal transduction mechanisms:Signal transduction mechanisms:Metabolism:Global:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Cellular processes and signaling:Metabolism:Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Global:Metabolism:Cellular processes and signaling:Metabolism:Energy Metabolism:Metabolism" 246 "Protein-tyrosine-phosphatase:Protein-tyrosine-phosphatase:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Lipid A core - O-antigen ligase and related enzymes:Lipid A core - O-antigen ligase and related enzymes:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:protein tyrosine phosphatase activity:ATP binding:regulation of transcription, DNA-dependent:protein dephosphorylation:transcription factor binding:arsenate reductase (glutaredoxin) activity:pathogenesis:transferase activity, transferring acyl groups other than amino-acyl groups:nucleoside-triphosphatase activity:antisigma factor binding:regulation of protein secretion:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Signal transduction mechanisms:Signal transduction mechanisms:ant_ant_sig:ant_ant_sig:Protein interactions:Regulatory functions:Cellular processes and signaling:Regulatory functions:Protein interactions:Cellular processes and signaling" 247 "Energy production and conversion:Energy production and conversion:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Methionyl-tRNA formyltransferase:Methionyl-tRNA formyltransferase:Methylated DNA-protein cysteine methyltransferase:Methylated DNA-protein cysteine methyltransferase:Dienelactone hydrolase and related enzymes:Dienelactone hydrolase and related enzymes:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Predicted phosphatases:Predicted phosphatases:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:Lysine efflux permease:Lysine efflux permease:Flagellar motor protein:Flagellar motor protein:FOG: GGDEF domain:FOG: GGDEF domain:Predicted N-acetylglucosaminyl transferase:Predicted N-acetylglucosaminyl transferase:Predicted symporter:Predicted symporter:Outer membrane receptor for ferrienterochelin and colicins:Outer membrane receptor for ferrienterochelin and colicins:Polysulphide reductase:Polysulphide reductase:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:magnesium ion binding:methylated-DNA-[protein]-cysteine S-methyltransferase activity:acetolactate synthase activity:methionyl-tRNA formyltransferase activity:signal transducer activity:receptor activity:transporter activity:binding:calcium ion binding:ATP binding:electron transport:DNA repair:transport:amino acid transport:chemotaxis:signal transduction:metabolic process:methyltransferase activity:formate dehydrogenase (NAD+) activity:phosphoglycolate phosphatase activity:tartronate-semialdehyde synthase activity:electron carrier activity:biosynthetic process:branched chain family amino acid biosynthetic process:cyclic nucleotide biosynthetic process:iron-chelate-transporting ATPase activity:hydrolase activity:phosphorus-oxygen lyase activity:thiamine pyrophosphate binding:intracellular signal transduction:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:One carbon pool by folate:One carbon pool by folate:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:acolac_lg:acolac_lg:GGDEF:GGDEF:ogt:ogt:sss:sss:HAD-SF-IA-v3:HAD-SF-IA-v3:PEP_exosort:PEP_exosort:Other:Cell envelope:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Carbohydrate Metabolism:Global:Cellular Processes:DNA replication, recombination, and repair:Cations and iron carrying compounds:Enzymes of unknown specificity:Pyruvate family:Other:Surface structures:DNA metabolism:Transport and binding proteins:Unknown function:Amino acid biosynthesis:Signal transduction:Cell envelope:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Cations and iron carrying compounds:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Pyruvate family:Signal transduction" 248 "Riboflavin synthase beta-chain:Riboflavin synthase beta-chain:DNA-directed RNA polymerase, beta' subunit/160 kD subunit:DNA-directed RNA polymerase, beta' subunit/160 kD subunit:Ribosomal protein L4:Ribosomal protein L4:Ribosomal protein L23:Ribosomal protein L23:Ribosomal protein L2:Ribosomal protein L2:Ribosomal protein L5:Ribosomal protein L5:3,4-dihydroxy-2-butanone 4-phosphate synthase:3,4-dihydroxy-2-butanone 4-phosphate synthase:Glycine/serine hydroxymethyltransferase:Glycine/serine hydroxymethyltransferase:Ribosomal protein S19:Ribosomal protein S19:Ribosomal protein L24:Ribosomal protein L24:Ribosomal protein L15:Ribosomal protein L15:3-oxoacyl-(acyl-carrier-protein) synthase:3-oxoacyl-(acyl-carrier-protein) synthase:CTP synthase (UTP-ammonia lyase):CTP synthase (UTP-ammonia lyase):Transcription termination factor:Transcription termination factor:Ribosomal protein L30/L7E:Ribosomal protein L30/L7E:Acetyl/propionyl-CoA carboxylase, alpha subunit:Acetyl/propionyl-CoA carboxylase, alpha subunit:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:nucleotide binding:DNA binding:transcription termination factor activity:RNA binding:structural constituent of ribosome:CTP synthase activity:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:GTP cyclohydrolase II activity:biotin carboxylase activity:3-oxoacyl-[acyl-carrier-protein] synthase activity:glycine hydroxymethyltransferase activity:pyruvate carboxylase activity:riboflavin synthase activity:ATP binding:pyrimidine nucleotide biosynthetic process:transcription, DNA-dependent:transcription termination, DNA-dependent:regulation of transcription, DNA-dependent:translation:glycine metabolic process:L-serine metabolic process:fatty acid biosynthetic process:metabolic process:3,4-dihydroxy-2-butanone-4-phosphate synthase activity:biosynthetic process:riboflavin biosynthetic process:biotin binding:transferase activity:pyridoxal phosphate binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Fatty acid biosynthesis:Fatty acid biosynthesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:One carbon pool by folate:One carbon pool by folate:Methane metabolism:Methane metabolism:Riboflavin metabolism:Riboflavin metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Ribosome:Ribosome:RNA polymerase:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:lumazine-synth:lumazine-synth:PyrG:PyrG:ribA:ribA:rpsS_bact:rpsS_bact:rplO_bact:rplO_bact:rplX_bact:rplX_bact:rplB_bact:rplB_bact:rpmD_bact:rpmD_bact:nusB:nusB:rpoC_TIGR:rpoC_TIGR:fabF:fabF:rplD_bact:rplD_bact:Ribosomal proteins: synthesis and modification:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Information storage and processing:Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Riboflavin, FMN, and FAD:Ribosomal proteins: synthesis and modification:Fatty acid and phospholipid metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Transcription:Protein synthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Transcription factors:DNA-dependent RNA polymerase:Pyrimidine ribonucleotide biosynthesis:Biosynthesis:Global:Genetic Information Processing:Information storage and processing:Metabolism:Metabolism:Energy Metabolism:Lipid Metabolism:Metabolism:Nucleotide Metabolism:Metabolism:Translation:Amino Acid Metabolism:Transcription:Metabolism of Cofactors and Vitamins:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Translation:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Transcription:DNA-dependent RNA polymerase:Transcription factors:Protein synthesis" 249 "Ketol-acid reductoisomerase:Ketol-acid reductoisomerase:Predicted sugar kinase:Predicted sugar kinase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Predicted metal-dependent hydrolase:Predicted metal-dependent hydrolase:Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):Acetolactate synthase, small (regulatory) subunit:Acetolactate synthase, small (regulatory) subunit:Pyruvate kinase:Pyruvate kinase:Carbamoylphosphate synthase small subunit:Carbamoylphosphate synthase small subunit:Signal transduction histidine kinase:Signal transduction histidine kinase:UDP-N-acetylmuramyl tripeptide synthase:UDP-N-acetylmuramyl tripeptide synthase:UDP-N-acetylmuramyl pentapeptide synthase:UDP-N-acetylmuramyl pentapeptide synthase:UDP-glucose pyrophosphorylase:UDP-glucose pyrophosphorylase:Predicted membrane-associated HD superfamily hydrolase:Predicted membrane-associated HD superfamily hydrolase:Outer membrane protein:Outer membrane protein:Carbon storage regulator (could also regulate swarming and quorum sensing):Carbon storage regulator (could also regulate swarming and quorum sensing):Uncharacterized conserved protein:Uncharacterized conserved protein:Phosphate starvation-inducible protein PhoH, predicted ATPase:Phosphate starvation-inducible protein PhoH, predicted ATPase:Uncharacterized conserved protein:Uncharacterized conserved protein:Cytochrome c-type biogenesis protein CcmE:Cytochrome c-type biogenesis protein CcmE:Signal transduction histidine kinase:Signal transduction histidine kinase:Flp pilus assembly protein TadD, contains TPR repeats:Flp pilus assembly protein TadD, contains TPR repeats:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:magnesium ion binding:nucleic acid binding:RNA binding:peptidyl-prolyl cis-trans isomerase activity:catalytic activity:UTP:glucose-1-phosphate uridylyltransferase activity:acetolactate synthase activity:branched-chain-amino-acid transaminase activity:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity:ketol-acid reductoisomerase activity:cyclophilin:pyruvate kinase activity:transporter activity:binding:ATP binding:UDP-glucose metabolic process:glycolysis:regulation of carbohydrate metabolic process:regulation of transcription, DNA-dependent:protein modification process:glutamine metabolic process:nitrogen compound metabolic process:transport:response to stress:signal transduction:regulation of cell shape:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity:biosynthetic process:branched chain family amino acid metabolic process:branched chain family amino acid biosynthetic process:purine ribonucleoside monophosphate biosynthetic process:peptidoglycan biosynthetic process:cellular response to phosphate starvation:mRNA metabolic process:nickel ion binding:amino acid binding:cytochrome complex assembly:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:deaminase activity:FK506-sensitive peptidyl-prolyl cis-trans isomerase:potassium ion binding:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity:coenzyme binding:cell division:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose and glucuronate interconversions:Pentose and glucuronate interconversions:Galactose metabolism:Galactose metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Lysine biosynthesis:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00043:TIGR00043:acolac_sm:acolac_sm:yjeF_cterm:yjeF_cterm:csrA:csrA:sensory_box:sensory_box:HDIG:HDIG:ilvC:ilvC:pyruv_kin:pyruv_kin:murE:murE:galU:galU:ilvE_I:ilvE_I:murF:murF:CPSaseIIsmall:CPSaseIIsmall:DivI1A_domain:DivI1A_domain:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Energy metabolism:Metabolism of Cofactors and Vitamins:Purines, pyrimidines, nucleosides, and nucleotides:Glycan Biosynthesis and Metabolism:Regulatory functions:Cellular processes and signaling:Energy metabolism:Glycolysis/gluconeogenesis:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Regulatory functions:RNA interactions:Small molecule interactions:Protein synthesis:Other:Unknown function:General:Amino acid biosynthesis:Pyruvate family:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Poorly characterized:Protein synthesis:Unknown function:Amino acid biosynthesis:Amino Acid Metabolism:Cell envelope:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Carbohydrate Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Biosynthesis and degradation of murein sacculus and peptidoglycan:Poorly characterized:Metabolism:Pyruvate family:General:Other:Small molecule interactions:RNA interactions:Pyrimidine ribonucleotide biosynthesis:Glycolysis/gluconeogenesis:Global:Environmental Information Processing:Metabolism:Metabolism:Signal Transduction:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Membrane Transport:Metabolism" 250 "Energy production and conversion:Energy production and conversion:Acetylglutamate semialdehyde dehydrogenase:Acetylglutamate semialdehyde dehydrogenase:Glutamyl- and glutaminyl-tRNA synthetases:Glutamyl- and glutaminyl-tRNA synthetases:Transketolase:Transketolase:Xanthosine triphosphate pyrophosphatase:Xanthosine triphosphate pyrophosphatase:Dihydroxyacid dehydratase/phosphogluconate dehydratase:Dihydroxyacid dehydratase/phosphogluconate dehydratase:Hydrogenase maturation factor:Hydrogenase maturation factor:Nucleoside-diphosphate-sugar epimerases:Nucleoside-diphosphate-sugar epimerases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:Glycine cleavage system H protein (lipoate-binding):Glycine cleavage system H protein (lipoate-binding):Aspartokinases:Aspartokinases:Predicted phosphatases:Predicted phosphatases:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:ABC-type dipeptide transport system, periplasmic component:ABC-type dipeptide transport system, periplasmic component:Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain:Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Uncharacterized membrane protein, required for N-linked glycosylation:Uncharacterized membrane protein, required for N-linked glycosylation:Alcohol dehydrogenase, class IV:Alcohol dehydrogenase, class IV:Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog:Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog:Sialic acid synthase:Sialic acid synthase:Cell division protein:Cell division protein:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase:Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain:Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):catalytic activity:N-acetyl-gamma-glutamyl-phosphate reductase activity:UDP-glucose 4-epimerase activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:aspartate kinase activity:dihydroxy-acid dehydratase activity:glycine cleavage system:glycine dehydrogenase (decarboxylating) activity:oligosaccharyl transferase activity:dolichyl-diphosphooligosaccharide-protein glycotransferase activity:peroxidase activity:protein histidine kinase activity:transketolase activity:glutamine-tRNA ligase activity:transporter activity:ATP binding:pentose-phosphate shunt:electron transport:mitochondrial electron transport, NADH to ubiquinone:regulation of transcription, DNA-dependent:glutamyl-tRNA aminoacylation:glutaminyl-tRNA aminoacylation:protein glycosylation:arginine biosynthetic process:glycine metabolic process:glycine catabolic process:cellular aromatic compound metabolic process:transport:response to oxidative stress:NADH dehydrogenase (ubiquinone) activity:metabolic process:cellular amino acid biosynthetic process:2-dehydro-3-deoxyglucarate aldolase activity:4-phytase activity:thiamine-phosphate kinase activity:electron carrier activity:branched chain family amino acid biosynthetic process:lipopolysaccharide biosynthetic process:FMN binding:carbohydrate biosynthetic process:amino acid binding:nucleoside-triphosphatase activity:heme binding:pyridoxal phosphate binding:thiamine pyrophosphate binding:cellular metabolic process:metal ion binding:protein dimerization activity:N-acylneuraminate-9-phosphate synthase activity:2-oxoglutarate synthase activity:N-acetylneuraminate synthase activity:coenzyme binding:NAD binding:iron-sulfur cluster binding:4 iron, 4 sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Pentose phosphate pathway:Pentose phosphate pathway:Galactose metabolism:Galactose metabolism:Ascorbate and aldarate metabolism:Ascorbate and aldarate metabolism:Purine metabolism:Purine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Thiamine metabolism:Thiamine metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00042:TIGR00042:ilvD:ilvD:tktlase_bact:tktlase_bact:glnS:glnS:gcvH:gcvH:asp_kin_monofn:asp_kin_monofn:argC:argC:hypE:hypE:Amino acids and amines:DNA replication, recombination, and repair:tRNA aminoacylation:Aspartate family:Glutamate family:Pyruvate family:Energy metabolism:DNA metabolism:Protein synthesis:Amino acid biosynthesis:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Translation:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Amino acids and amines:Pentose phosphate pathway:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Amino acid biosynthesis:Aspartate family:Glutamate family:Pyruvate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Pentose phosphate pathway" 251 "Energy production and conversion:Energy production and conversion:Argininosuccinate lyase:Argininosuccinate lyase:Transaldolase:Transaldolase:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:Signal transduction histidine kinase:Signal transduction histidine kinase:Permeases of the drug/metabolite transporter (DMT) superfamily:Permeases of the drug/metabolite transporter (DMT) superfamily:ABC-type transport system involved in cytochrome c biogenesis, permease component:ABC-type transport system involved in cytochrome c biogenesis, permease component:Predicted UDP-glucose 6-dehydrogenase:Predicted UDP-glucose 6-dehydrogenase:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase:ABC-type Mn/Zn transport systems, ATPase component:ABC-type Mn/Zn transport systems, ATPase component:ABC-type sugar transport systems, permease components:ABC-type sugar transport systems, permease components:DNA-directed RNA polymerase specialized sigma subunit:DNA-directed RNA polymerase specialized sigma subunit:CMP-2-keto-3-deoxyoctulosonic acid synthetase:CMP-2-keto-3-deoxyoctulosonic acid synthetase:Ribonucleases G and E:Ribonucleases G and E:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:DnaK suppressor protein:DnaK suppressor protein:Adenosine deaminase:Adenosine deaminase:ABC-type transport system involved in cytochrome c biogenesis, permease component:ABC-type transport system involved in cytochrome c biogenesis, permease component:Tfp pilus assembly protein PilF:Tfp pilus assembly protein PilF:Predicted transcriptional regulator with C-terminal CBS domains:Predicted transcriptional regulator with C-terminal CBS domains:ABC-type uncharacterized transport systems, ATPase components:ABC-type uncharacterized transport systems, ATPase components:Polysulphide reductase:Polysulphide reductase:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:catalytic activity:DNA-directed RNA polymerase activity:UDP-glucose 6-dehydrogenase activity:argininosuccinate lyase activity:ribonuclease activity:phosphatidylserine decarboxylase activity:protein histidine kinase activity:sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity:transporter activity:binding:ATP binding:carbohydrate metabolic process:electron transport:transcription initiation, DNA-dependent:regulation of transcription, DNA-dependent:RNA processing:transport:metabolic process:zinc ion binding:respiratory chain complex IV assembly:3-deoxy-manno-octulosonate cytidylyltransferase activity:lipopolysaccharide biosynthetic process:lipid A biosynthetic process:heme transporter activity:monosaccharide-transporting ATPase activity:heme transport:transferase activity, transferring acyl groups:ATPase activity:sigma factor activity:cytochrome complex assembly:peptidyl-histidine phosphorylation:pyridoxal phosphate binding:arginine biosynthetic process via ornithine:sequence-specific DNA binding:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity:NAD binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pentose phosphate pathway:Pentose phosphate pathway:Pentose and glucuronate interconversions:Pentose and glucuronate interconversions:Ascorbate and aldarate metabolism:Ascorbate and aldarate metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:RNA degradation:RNA degradation:RNA polymerase:RNA polymerase:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:RNaseEG:RNaseEG:argH:argH:fsa_talC_mipB:fsa_talC_mipB:lipid_A_lpxD:lipid_A_lpxD:FliA_WhiG:FliA_WhiG:NDP-sugDHase:NDP-sugDHase:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Energy metabolism:Pentose phosphate pathway:Transcription:Degradation of RNA:Amino acid biosynthesis:Glutamate family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Pentose phosphate pathway:Global:Global:Environmental Information Processing:Genetic Information Processing:Cell envelope:Metabolism:Metabolism:Signal Transduction:Membrane Transport:Folding Sorting and Degradation:Transcription:Signal Transduction:Membrane Transport:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Environmental Information Processing:Folding Sorting and Degradation:Transcription:Genetic Information Processing:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Carbohydrate Metabolism:Degradation of RNA:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Glutamate family:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Energy metabolism:Transcription:Amino acid biosynthesis:Metabolism" 252 "" 253 "Transposase and inactivated derivatives:Transposase and inactivated derivatives:Mu-like prophage protein gp29:Mu-like prophage protein gp29:DNA binding:transposase activity:transposition, DNA-mediated:Replication, recombination and repair:Replication, recombination and repair:Function unknown:Function unknown:Information storage and processing:Poorly characterized:Information storage and processing:Poorly characterized" 254 "Predicted GTPase, probable translation factor:Predicted GTPase, probable translation factor:Diaminopimelate decarboxylase:Diaminopimelate decarboxylase:7-keto-8-aminopelargonate synthetase and related enzymes:7-keto-8-aminopelargonate synthetase and related enzymes:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Predicted Fe-S oxidoreductases:Predicted Fe-S oxidoreductases:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Primosomal protein N' (replication factor Y) - superfamily II helicase:Primosomal protein N' (replication factor Y) - superfamily II helicase:Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases:Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases:NaMN:DMB phosphoribosyltransferase:NaMN:DMB phosphoribosyltransferase:Predicted membrane-associated, metal-dependent hydrolase:Predicted membrane-associated, metal-dependent hydrolase:HD-GYP domain:HD-GYP domain:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted ATPase:Predicted ATPase:Uncharacterized protein related to glutamine synthetase:Uncharacterized protein related to glutamine synthetase:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:xanthine phosphoribosyltransferase activity:nucleic acid binding:DNA binding:catalytic activity:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity:glutamate-ammonia ligase activity:ATP binding:GTP binding:DNA replication:DNA modification:DNA methylation:glutamine biosynthetic process:nitrogen compound metabolic process:ATP-dependent helicase activity:metabolic process:N-methyltransferase activity:zinc ion binding:sulfuric ester hydrolase activity:8-amino-7-oxononanoate synthase activity:diaminopimelate decarboxylase activity:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity:starch synthase activity:biosynthetic process:lysine biosynthetic process via diaminopimelate:nucleoside metabolic process:cobalamin biosynthetic process:ferrous iron transmembrane transporter activity:ferrous iron transport:carbohydrate biosynthetic process:transferase activity:transferase activity, transferring hexosyl groups:transferase activity, transferring nitrogenous groups:pyridoxal phosphate binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Fatty acid biosynthesis:Fatty acid biosynthesis:Purine metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Lysine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Riboflavin metabolism:Riboflavin metabolism:Biotin metabolism:Biotin metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Nitrogen metabolism:Biosynthesis of unsaturated fatty acids:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Homologous recombination:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00092:TIGR00092:HDIG:HDIG:priA:priA:lysA:lysA:primase_Cterm:primase_Cterm:C4_traR_proteo:C4_traR_proteo:cobT_DBIPRT:cobT_DBIPRT:Signal Transduction:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:DNA replication, recombination, and repair:Prophage functions:General:Aspartate family:Heme, porphyrin, and cobalamin:DNA metabolism:Mobile and extrachromosomal element functions:Unknown function:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Replication and Repair:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Mobile and extrachromosomal element functions:Prophage functions:Unknown function:General:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism" 255 "Energy production and conversion:Energy production and conversion:Asparagine synthase (glutamine-hydrolyzing):Asparagine synthase (glutamine-hydrolyzing):Glycosyltransferase:Glycosyltransferase:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:Amino acid permeases:Amino acid permeases:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:Putative protein-S-isoprenylcysteine methyltransferase:Putative protein-S-isoprenylcysteine methyltransferase:Nitrate reductase gamma subunit:Nitrate reductase gamma subunit:Mg/Co/Ni transporter MgtE (contains CBS domain):Mg/Co/Ni transporter MgtE (contains CBS domain):3-methyladenine DNA glycosylase:3-methyladenine DNA glycosylase:Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit:Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit:Uncharacterized conserved protein:Uncharacterized conserved protein:Selenocysteine-specific translation elongation factor:Selenocysteine-specific translation elongation factor:Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit:Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit:Amino acid transport and metabolism:Amino acid transport and metabolism:selenocysteine incorporation:RNA binding:translation elongation factor activity:catalytic activity:GTPase activity:acid phosphatase activity:asparagine synthase (glutamine-hydrolyzing) activity:aminoacyl-tRNA ligase activity:ionotropic glutamate receptor activity:extracellular-glutamate-gated ion channel activity:ATP binding:GTP binding:electron transport:base-excision repair:tRNA aminoacylation for protein translation:asparagine biosynthetic process:nitrogen compound metabolic process:transport:cation transport:amino acid transport:metabolic process:cation transmembrane transporter activity:DNA-3-methyladenine glycosylase I activity:nitrate reductase activity:biosynthetic process:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:ATPase activity:heme binding:nitrite reductase (cytochrome, ammonia-forming) activity:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Base excision repair:Base excision repair:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:small_GTP:small_GTP:araaP:araaP:asn_synth_AEB:asn_synth_AEB:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Transport and binding proteins:Amino acid biosynthesis:General:Amino acids, peptides and amines:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Replication and Repair:Amino Acid Metabolism:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Energy Metabolism:Amino Acid Metabolism:Unknown function:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transport and binding proteins:Amino acids, peptides and amines:Unknown function:General" 256 "Ammonia permease:Ammonia permease:Predicted permeases:Predicted permeases:Periplasmic protein TonB, links inner and outer membranes:Periplasmic protein TonB, links inner and outer membranes:Cation/multidrug efflux pump:Cation/multidrug efflux pump:Membrane-fusion protein:Membrane-fusion protein:Transcriptional regulator:Transcriptional regulator:Outer membrane protein:Outer membrane protein:Membrane transporters of cations and cationic drugs:Membrane transporters of cations and cationic drugs:Outer membrane receptor for ferrienterochelin and colicins:Outer membrane receptor for ferrienterochelin and colicins:ABC-type Co2+ transport system, periplasmic component:ABC-type Co2+ transport system, periplasmic component:sequence-specific DNA binding transcription factor activity:receptor activity:transporter activity:iron ion transmembrane transporter activity:regulation of transcription, DNA-dependent:transport:iron ion transport:lipid binding:ammonium transmembrane transporter activity:protein transporter activity:protein secretion:protein transport:specific transcriptional repressor activity:negative regulation of transcription, DNA-dependent:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:General function prediction only:General function prediction only:amt:amt:2A0602:2A0602:tonB_Cterm:tonB_Cterm:RND_mfp:RND_mfp:outer_NodT:outer_NodT:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Information storage and processing:Poorly characterized:Porins:Metabolism:Cellular processes and signaling:Transport and binding proteins:Porins:Cations and iron carrying compounds:Unknown substrate:Information storage and processing:Cations and iron carrying compounds:Unknown substrate:Transport and binding proteins:Metabolism:Cellular processes and signaling:Poorly characterized" 257 "Energy production and conversion:Energy production and conversion:Diaminopimelate decarboxylase:Diaminopimelate decarboxylase:Nitrogen regulatory protein PII:Nitrogen regulatory protein PII:Biotin carboxylase:Biotin carboxylase:Signal transduction histidine kinase:Signal transduction histidine kinase:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:Sugar transferases involved in lipopolysaccharide synthesis:Sugar transferases involved in lipopolysaccharide synthesis:Nitrogenase molybdenum-iron protein, alpha and beta chains:Nitrogenase molybdenum-iron protein, alpha and beta chains:Uncharacterized protein involved in exopolysaccharide biosynthesis:Uncharacterized protein involved in exopolysaccharide biosynthesis:Type II secretory pathway, component ExeA (predicted ATPase):Type II secretory pathway, component ExeA (predicted ATPase):Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:nucleotide binding:ciliary or flagellar motility:DNA binding:sequence-specific DNA binding transcription factor activity:motor activity:catalytic activity:cysteine-type endopeptidase activity:protein histidine kinase activity:signal transducer activity:ATP binding:electron transport:regulation of transcription, DNA-dependent:proteolysis:regulation of nitrogen utilization:chemotaxis:signal transduction:diaminopimelate decarboxylase activity:lipopolysaccharide biosynthetic process:nitrogen fixation:DNA integration:nitrogenase activity:iron-iron nitrogenase activity:molybdenum-iron nitrogenase activity:vanadium-iron nitrogenase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:pyridoxal phosphate binding:enzyme regulator activity:Lipid transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Nitrogen metabolism:Nitrogen metabolism:Signal transduction mechanisms:Signal transduction mechanisms:EpsI_fam:EpsI_fam:PEP_his_kin:PEP_his_kin:pepcterm_ChnLen:pepcterm_ChnLen:EpsB_2:EpsB_2:pepcterm_ATPase:pepcterm_ATPase:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Two-component systems:Unknown substrate:Protein and peptide secretion and trafficking:Metabolism:Cell envelope:Signal transduction:Transport and binding proteins:Energy Metabolism:Cellular processes and signaling:Metabolism:Metabolism:Energy Metabolism:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Unknown substrate:Signal transduction:Two-component systems:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Protein fate" 258 "Energy production and conversion:Energy production and conversion:Putative translation factor (SUA5):Putative translation factor (SUA5):Nicotinate-nucleotide pyrophosphorylase:Nicotinate-nucleotide pyrophosphorylase:Uncharacterized conserved protein:Uncharacterized conserved protein:Glycerol-3-phosphate dehydrogenase:Glycerol-3-phosphate dehydrogenase:Ribosomal protein L20:Ribosomal protein L20:23S rRNA methylase:23S rRNA methylase:Quinolinate synthase:Quinolinate synthase:Predicted integral membrane protein:Predicted integral membrane protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Glycosyltransferase:Glycosyltransferase:NAD/FAD-utilizing enzyme apparently involved in cell division:NAD/FAD-utilizing enzyme apparently involved in cell division:Na+-driven multidrug efflux pump:Na+-driven multidrug efflux pump:Signal recognition particle GTPase:Signal recognition particle GTPase:rRNA methylases:rRNA methylases:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Signal peptidase I:Signal peptidase I:Thioredoxin-like proteins and domains:Thioredoxin-like proteins and domains:Uncharacterized conserved protein:Uncharacterized conserved protein:FOG: GGDEF domain:FOG: GGDEF domain:tRNA(1-methyladenosine) methyltransferase and related methyltransferases:tRNA(1-methyladenosine) methyltransferase and related methyltransferases:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain:Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:rRNA modification:cell killing:RNA binding:structural constituent of ribosome:methylated-DNA-[protein]-cysteine S-methyltransferase activity:glycerol-3-phosphate dehydrogenase [NAD+] activity:nicotinate-nucleotide diphosphorylase (carboxylating) activity:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity:iron ion binding:ATP binding:GTP binding:carbohydrate metabolic process:RNA processing:translation:proteolysis:SRP-dependent cotranslational protein targeting to membrane:drug transmembrane transport:tRNA processing:metallopeptidase activity:7S RNA binding:rRNA methyltransferase activity:glucose-1-phosphate adenylyltransferase activity:quinolinate synthetase A activity:signal peptidase I activity:succinyl-diaminopimelate desuccinylase activity:tRNA (guanosine-2'-O-)-methyltransferase activity:biosynthetic process:lysine biosynthetic process:cyclic nucleotide biosynthetic process:NAD biosynthetic process:RNA modification:drug transmembrane transporter activity:antiporter activity:iron-sulfur cluster assembly:tRNA (adenine-N1-)-methyltransferase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:phosphorus-oxygen lyase activity:nucleoside-triphosphatase activity:intracellular signal transduction:glycerol-3-phosphate catabolic process:metal ion binding:protein dimerization activity:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity:flavin adenine dinucleotide binding:NAD binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Lysine biosynthesis:Lysine biosynthesis:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Ribosome:Ribosome:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00057:TIGR00057:ftsY:ftsY:nadC:nadC:gidA:gidA:GGDEF:GGDEF:matE:matE:rplT_bact:rplT_bact:TIGR01033:TIGR01033:sigpep_I_bact:sigpep_I_bact:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Protein and peptide secretion and trafficking:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification:DNA interactions:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Folding Sorting and Degradation:Translation:Lipid Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Signal transduction:Biosynthesis of cofactors, prosthetic groups, and carriers:Unknown function:Transport and binding proteins:Protein fate:Protein synthesis:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Lipid Metabolism:Regulatory functions:Amino Acid Metabolism:Other:Metabolism of Cofactors and Vitamins:Pyridine nucleotides:Genetic Information Processing:Translation:General:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Other:Regulatory functions:DNA interactions:Protein synthesis:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Other:Unknown function" 259 "Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase:Signal transduction histidine kinase:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):ATP binding:regulation of transcription, DNA-dependent:peptidyl-histidine phosphorylation:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:tape_meas_TP901:tape_meas_TP901:Regulatory functions:Small molecule interactions:Mobile and extrachromosomal element functions:Prophage functions:Cellular processes and signaling:Prophage functions:Small molecule interactions:Regulatory functions:Mobile and extrachromosomal element functions:Cellular processes and signaling" 260 "Energy production and conversion:Energy production and conversion:Pseudouridylate synthases, 23S RNA-specific:Pseudouridylate synthases, 23S RNA-specific:Signal transduction histidine kinase:Signal transduction histidine kinase:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:Phosphomannomutase:Phosphomannomutase:L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases:L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases:TRAP-type C4-dicarboxylate transport system, periplasmic component:TRAP-type C4-dicarboxylate transport system, periplasmic component:Uncharacterized conserved protein:Uncharacterized conserved protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Putative glycerate kinase:Putative glycerate kinase:Tfp pilus assembly protein, pilus retraction ATPase PilT:Tfp pilus assembly protein, pilus retraction ATPase PilT:Type II secretory pathway, component ExeA (predicted ATPase):Type II secretory pathway, component ExeA (predicted ATPase):Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):pseudouridine synthesis:sequence-specific DNA binding transcription factor activity:RNA binding:dephospho-CoA kinase activity:phosphomannomutase activity:ATP binding:carbohydrate metabolic process:electron transport:DNA repair:regulation of transcription, DNA-dependent:transport:amino acid transport:cell cycle:signal transduction:transcription factor binding:pseudouridine synthase activity:FMN binding:coenzyme A biosynthetic process:oxidoreductase activity:hydroxypyruvate reductase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell motility:Cell motility:Fructose and mannose metabolism:Fructose and mannose metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:rluA_subfam:rluA_subfam:sensory_box:sensory_box:TIGR00296:TIGR00296:dctP:dctP:pilT_fam:pilT_fam:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Global:Membrane Transport:Environmental Information Processing:Amino Acid Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cellular processes:Chemotaxis and motility:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Unknown function:Cellular processes:Transport and binding proteins:Protein synthesis:Regulatory functions:General:Chemotaxis and motility:Carbohydrates, organic alcohols, and acids:tRNA and rRNA base modification:Small molecule interactions:Global:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Amino Acid Metabolism:Carbohydrate Metabolism" 261 "Predicted Co/Zn/Cd cation transporters:Predicted Co/Zn/Cd cation transporters:Mg-dependent DNase:Mg-dependent DNase:N-formylmethionyl-tRNA deformylase:N-formylmethionyl-tRNA deformylase:Dienelactone hydrolase and related enzymes:Dienelactone hydrolase and related enzymes:Biotin synthase and related enzymes:Biotin synthase and related enzymes:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:Aspartate ammonia-lyase:Aspartate ammonia-lyase:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold:Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold:Predicted GTPases:Predicted GTPases:NAD(FAD)-utilizing enzyme possibly involved in translation:NAD(FAD)-utilizing enzyme possibly involved in translation:Uncharacterized conserved protein:Uncharacterized conserved protein:DNA segregation ATPase FtsK/SpoIIIE and related proteins:DNA segregation ATPase FtsK/SpoIIIE and related proteins:Transcriptional regulators:Transcriptional regulators:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:DNA binding:sequence-specific DNA binding transcription factor activity:biotin synthase activity:iron ion binding:ATP binding:GTP binding:electron transport:regulation of transcription, DNA-dependent:translation:protein modification process:cation transport:cell cycle:chromosome segregation:tRNA processing:metabolic process:cation transmembrane transporter activity:formylmethionine deformylase activity:aspartate ammonia-lyase activity:electron carrier activity:biotin biosynthetic process:cyclic nucleotide biosynthetic process:disulfide oxidoreductase activity:transferase activity:hydrolase activity:phosphorus-oxygen lyase activity:nucleoside-triphosphatase activity:intracellular signal transduction:peptide deformylase activity:flavin adenine dinucleotide binding:cell division:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Thiamine metabolism:Thiamine metabolism:Biotin metabolism:Biotin metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:TIGR00010:TIGR00010:pept_deformyl:pept_deformyl:gid_trmFO:gid_trmFO:small_GTP:small_GTP:CDF:CDF:rSAM_HydG:rSAM_HydG:rSAM_HydE:rSAM_HydE:hyd_TM1266:hyd_TM1266:DNA interactions:Regulatory functions:DNA interactions:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein modification and repair:Transport and binding proteins:Cations and iron carrying compounds:Unknown function:Enzymes of unknown specificity:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Amino Acid Metabolism:Energy Metabolism:Metabolism:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins:Metabolism:Cellular processes and signaling:Information storage and processing:Metabolism:Global:Amino Acid Metabolism:Energy Metabolism:tRNA and rRNA base modification:Unknown function:Transport and binding proteins:Protein fate:Protein synthesis:Regulatory functions:General:Enzymes of unknown specificity:Cations and iron carrying compounds:Protein modification and repair:Global:Metabolism:Metabolism of Cofactors and Vitamins" 262 "Energy production and conversion:Energy production and conversion:3-phosphoglycerate kinase:3-phosphoglycerate kinase:Argininosuccinate synthase:Argininosuccinate synthase:Carbonic anhydrase:Carbonic anhydrase:Isocitrate dehydrogenases:Isocitrate dehydrogenases:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:Spermidine/putrescine-binding periplasmic protein:Spermidine/putrescine-binding periplasmic protein:Predicted ATPase or kinase:Predicted ATPase or kinase:Amino acid permeases:Amino acid permeases:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:6Fe-6S prismane cluster-containing protein:6Fe-6S prismane cluster-containing protein:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:ABC-type spermidine/putrescine transport system, permease component II:ABC-type spermidine/putrescine transport system, permease component II:Membrane-associated lipoprotein involved in thiamine biosynthesis:Membrane-associated lipoprotein involved in thiamine biosynthesis:ABC-type phosphate/phosphonate transport system, periplasmic component:ABC-type phosphate/phosphonate transport system, periplasmic component:ABC-type phosphate/phosphonate transport system, permease component:ABC-type phosphate/phosphonate transport system, permease component:Predicted NADH:ubiquinone oxidoreductase, subunit RnfA:Predicted NADH:ubiquinone oxidoreductase, subunit RnfA:Predicted NADH:ubiquinone oxidoreductase, subunit RnfD:Predicted NADH:ubiquinone oxidoreductase, subunit RnfD:Predicted NADH:ubiquinone oxidoreductase, subunit RnfG:Predicted NADH:ubiquinone oxidoreductase, subunit RnfG:Predicted NADH:ubiquinone oxidoreductase, subunit RnfE:Predicted NADH:ubiquinone oxidoreductase, subunit RnfE:Ornithine/acetylornithine aminotransferase:Ornithine/acetylornithine aminotransferase:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity:acid phosphatase activity:argininosuccinate synthase activity:carbonate dehydratase activity:hydroxymethylbilane synthase activity:isocitrate dehydrogenase (NAD+) activity:isocitrate dehydrogenase (NADP+) activity:ornithine carbamoyltransferase activity:phosphoglycerate kinase activity:transporter activity:iron ion binding:ATP binding:glycolysis:tricarboxylic acid cycle:electron transport:regulation of transcription, DNA-dependent:arginine metabolic process:arginine biosynthetic process:transport:amino acid transport:signal transduction:NADH dehydrogenase (ubiquinone) activity:metabolic process:zinc ion binding:electron carrier activity:biosynthetic process:thiamine biosynthetic process:FMN binding:phosphonate transmembrane transporter activity:phosphonate transport:carbon utilization:nickel ion binding:oxidoreductase activity, acting on NADH or NADPH:transferase activity, transferring nitrogenous groups:peptidyl-histidine phosphorylation:carbon-monoxide dehydrogenase (acceptor) activity:heme binding:pyridoxal phosphate binding:tetrapyrrole biosynthetic process:succinylornithine transaminase activity:NAD binding:iron-sulfur cluster binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Glutathione metabolism:Glutathione metabolism:Nitrotoluene degradation:Nitrotoluene degradation:Methane metabolism:Methane metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:argG:argG:HI0065_YjeE:HI0065_YjeE:sensory_box:sensory_box:argD:argD:araaP:araaP:PhnE:PhnE:3A0109s03R:3A0109s03R:CO_DH_cata:CO_DH_cata:rnfA:rnfA:rnfD:rnfD:rnfE:rnfE:Energy metabolism:Electron transport:Regulatory functions:Small molecule interactions:Transport and binding proteins:Amino acids, peptides and amines:Anions:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Glutamate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Transport and binding proteins:Regulatory functions:Energy metabolism:Glutamate family:Enzymes of unknown specificity:Anions:Carbohydrate Metabolism:Amino acids, peptides and amines:Small molecule interactions:Electron transport:Global:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Xenobiotics Biodegradation and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Energy Metabolism:Xenobiotics Biodegradation and Metabolism:Carbohydrate Metabolism:Environmental Information Processing:Membrane Transport:Metabolism:Global:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Amino acid biosynthesis:Unknown function" 263 "Energy production and conversion:Energy production and conversion:Restriction endonuclease S subunits:Restriction endonuclease S subunits:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulator:Transcriptional regulator:Micrococcal nuclease (thermonuclease) homologs:Micrococcal nuclease (thermonuclease) homologs:L-lactate permease:L-lactate permease:N-terminal domain of molybdenum-binding protein:N-terminal domain of molybdenum-binding protein:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):nucleotide binding:nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:peptidyl-prolyl cis-trans isomerase activity:L-aspartate:2-oxoglutarate aminotransferase activity:nuclease activity:cyclophilin:ATP binding:DNA modification:regulation of transcription, DNA-dependent:transcription factor binding:Type I site-specific deoxyribonuclease activity:biosynthetic process:lactate transmembrane transporter activity:lactate transport:specific transcriptional repressor activity:nucleoside-triphosphatase activity:FK506-sensitive peptidyl-prolyl cis-trans isomerase:pyridoxal phosphate binding:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:negative regulation of transcription, DNA-dependent:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:lctP:lctP:Defense mechanisms:Defense mechanisms:Metabolism:Poorly characterized:Carbohydrates, organic alcohols, and acids:Transport and binding proteins:Small molecule interactions:Regulatory functions:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Transport and binding proteins:Regulatory functions:Carbohydrates, organic alcohols, and acids:Information storage and processing:Small molecule interactions:Cellular processes and signaling" 264 "Energy production and conversion:Energy production and conversion:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:NADPH:quinone reductase and related Zn-dependent oxidoreductases:NADPH:quinone reductase and related Zn-dependent oxidoreductases:Predicted GTPases:Predicted GTPases:Site-specific recombinase XerD:Site-specific recombinase XerD:Amino acid transport and metabolism:Amino acid transport and metabolism:DNA binding:single-stranded DNA binding:catalytic activity:GTPase activity:NADPH:quinone reductase activity:ATP binding:GTP binding:DNA recombination:metabolic process:zinc ion binding:DNA integration:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:Replication, recombination and repair:Replication, recombination and repair:ABC transporters:ABC transporters:General function prediction only:General function prediction only:TIGR00157:TIGR00157:Membrane Transport:Protein synthesis:Translation factors:Information storage and processing:Metabolism:Poorly characterized:Environmental Information Processing:Poorly characterized:Metabolism:Information storage and processing:Protein synthesis:Translation factors:Environmental Information Processing:Membrane Transport" 265 "Energy production and conversion:Energy production and conversion:Succinyl-CoA synthetase, beta subunit:Succinyl-CoA synthetase, beta subunit:rRNA methylase:rRNA methylase:Integrase:Integrase:Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake:Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake:DNA modification methylase:DNA modification methylase:TRAP-type C4-dicarboxylate transport system, large permease component:TRAP-type C4-dicarboxylate transport system, large permease component:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Dioxygenases related to 2-nitropropane dioxygenase:Dioxygenases related to 2-nitropropane dioxygenase:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:RNA binding:succinate-CoA ligase (ADP-forming) activity:binding:ATP binding:electron transport:DNA methylation:DNA recombination:regulation of transcription, DNA-dependent:RNA processing:metabolic process:N-methyltransferase activity:RNA methyltransferase activity:site-specific DNA-methyltransferase (adenine-specific) activity:DNA mediated transformation:RNA modification:DNA integration:nitronate monooxygenase activity:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Propanoate metabolism:Propanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Function unknown:Function unknown:dprA:dprA:dctM:dctM:sucCoAalpha:sucCoAalpha:excise:excise:tol_pal_ybgF:tol_pal_ybgF:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Global:Carbohydrate Metabolism:Metabolism:Poorly characterized:Energy metabolism:TCA cycle:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cellular processes:DNA transformation:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Unknown function:Cellular processes:Transport and binding proteins:Energy metabolism:General:DNA transformation:Carbohydrates, organic alcohols, and acids:TCA cycle:Global:Metabolism:Metabolism:Carbohydrate Metabolism" 266 "Energy production and conversion:Energy production and conversion:Ribonuclease HII:Ribonuclease HII:Anaerobic dehydrogenases, typically selenocysteine-containing:Anaerobic dehydrogenases, typically selenocysteine-containing:Glycerol dehydrogenase and related enzymes:Glycerol dehydrogenase and related enzymes:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Adenylate kinase and related kinases:Adenylate kinase and related kinases:F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K:F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K:Outer membrane protein:Outer membrane protein:Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:Ferredoxin:Ferredoxin:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Uncharacterized protein predicted to be involved in DNA repair:Uncharacterized protein predicted to be involved in DNA repair:Uncharacterized conserved protein:Uncharacterized conserved protein:Polysulphide reductase:Polysulphide reductase:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Nucleotide transport and metabolism:DNA binding:RNA binding:3-dehydroquinate synthase activity:DNA-directed DNA polymerase activity:hydrogen-transporting two-sector ATPase activity:adenylate kinase activity:endoribonuclease activity:ribonuclease H activity:transporter activity:ATP binding:electron transport:nucleobase-containing compound metabolic process:RNA catabolic process:protein folding:transport:metabolic process:electron carrier activity:aromatic amino acid family biosynthetic process:cobalamin biosynthetic process:protein transport:ATP synthesis coupled proton transport:hydrogen-translocating F-type ATPase activity:oxidoreductase activity:molybdenum ion binding:cobyrinic acid a,c-diamide synthase activity:metal ion binding:hydrogen ion transporting ATP synthase activity, rotational mechanism:proton-transporting ATPase activity, rotational mechanism:glycerol-1-phosphate dehydrogenase [NAD(P)+] activity:iron-sulfur cluster binding:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Oxidative phosphorylation:Oxidative phosphorylation:Purine metabolism:Purine metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:DNA replication:DNA replication:Function unknown:Function unknown:cas1:cas1:ATP_synt_c:ATP_synt_c:Poorly characterized:Energy Metabolism:Cellular processes and signaling:Genetic Information Processing:Global:ATP-proton motive force interconversion:Other:Energy metabolism:Mobile and extrachromosomal element functions:Metabolism:Replication and Repair:Nucleotide Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Nucleotide Metabolism:Genetic Information Processing:Replication and Repair:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Mobile and extrachromosomal element functions:Other:Information storage and processing:Metabolism:Metabolism" 267 "Methylated DNA-protein cysteine methyltransferase:Methylated DNA-protein cysteine methyltransferase:ABC-type antimicrobial peptide transport system, permease component:ABC-type antimicrobial peptide transport system, permease component:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Flagellar motor protein:Flagellar motor protein:DNA-directed RNA polymerase, subunit K/omega:DNA-directed RNA polymerase, subunit K/omega:Anaerobic glycerol-3-phosphate dehydrogenase:Anaerobic glycerol-3-phosphate dehydrogenase:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted spermidine synthase with an N-terminal membrane domain:Predicted spermidine synthase with an N-terminal membrane domain:Amino acid transport and metabolism:Amino acid transport and metabolism:DNA binding:sequence-specific DNA binding transcription factor activity:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:methylated-DNA-[protein]-cysteine S-methyltransferase activity:glycerol-3-phosphate dehydrogenase activity:electron transport:DNA repair:transcription, DNA-dependent:regulation of transcription, DNA-dependent:biosynthetic process:nucleotide metabolic process:transferase activity, transferring nitrogenous groups:hydrolase activity:pyridoxal phosphate binding:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:Metabolic pathways:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:RNA polymerase:RNA polymerase:General function prediction only:General function prediction only:Function unknown:Function unknown:ogt:ogt:rpoZ:rpoZ:glycerol3P_GlpB:glycerol3P_GlpB:Defense mechanisms:Defense mechanisms:DNA metabolism:DNA replication, recombination, and repair:Transcription:DNA-dependent RNA polymerase:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Lipid Metabolism:Metabolism:Cell Motility:Metabolism:Genetic Information Processing:Cellular Processes:Global:Anaerobic:DNA replication, recombination, and repair:DNA-dependent RNA polymerase:Energy metabolism:DNA metabolism:Transcription:Transcription:Nucleotide Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Lipid Metabolism:Nucleotide Metabolism:Genetic Information Processing:Transcription:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Anaerobic" 268 "Energy production and conversion:Energy production and conversion:Phosphoglucomutase:Phosphoglucomutase:Thymidylate kinase:Thymidylate kinase:1,4-alpha-glucan branching enzyme:1,4-alpha-glucan branching enzyme:Membrane protease subunits, stomatin/prohibitin homologs:Membrane protease subunits, stomatin/prohibitin homologs:Nucleoside-diphosphate-sugar epimerases:Nucleoside-diphosphate-sugar epimerases:Glycerol-3-phosphate dehydrogenase:Glycerol-3-phosphate dehydrogenase:Predicted permease:Predicted permease:Lipid A disaccharide synthetase:Lipid A disaccharide synthetase:Predicted ATP-dependent serine protease:Predicted ATP-dependent serine protease:Oxygen-sensitive ribonucleoside-triphosphate reductase:Oxygen-sensitive ribonucleoside-triphosphate reductase:Long-chain fatty acid transport protein:Long-chain fatty acid transport protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized conserved protein:Chemotaxis protein:Chemotaxis protein:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Predicted permease, DMT superfamily:Predicted permease, DMT superfamily:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):damaged DNA binding:catalytic activity:1,4-alpha-glucan branching enzyme activity:methylated-DNA-[protein]-cysteine S-methyltransferase activity:ATP-dependent peptidase activity:serine-type endopeptidase activity:glycerol-3-phosphate dehydrogenase activity:hydrolase activity, hydrolyzing O-glycosyl compounds:phosphoglucomutase activity:thymidylate kinase activity:receptor activity:transporter activity:sugar:hydrogen symporter activity:iron ion binding:ATP binding:carbohydrate metabolic process:glycogen biosynthetic process:glycerol-3-phosphate metabolic process:electron transport:dTDP biosynthetic process:dTTP biosynthetic process:DNA repair:regulation of transcription, DNA-dependent:proteolysis:transport:lipid-A-disaccharide synthase activity:ribonucleoside-triphosphate reductase activity:electron carrier activity:lipid A biosynthetic process:phosphoenolpyruvate-dependent sugar phosphotransferase system:racemase and epimerase activity, acting on carbohydrates and derivatives:nucleoside-triphosphatase activity:heme binding:cation binding:[formate-C-acetyltransferase]-activating enzyme activity:cellular metabolic process:coenzyme binding:iron-sulfur cluster binding:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Galactose metabolism:Galactose metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:DTMP_kinase:DTMP_kinase:lpxB:lpxB:sms:sms:pgm:pgm:branching_enzym:branching_enzym:NrdD:NrdD:NrdG2:NrdG2:Carbohydrate Metabolism:Global:Cellular Processes:Biosynthesis and degradation of polysaccharides:Sugars:Nucleotide and nucleoside interconversions:2'-Deoxyribonucleotide metabolism:DNA replication, recombination, and repair:Protein modification and repair:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Energy metabolism:Purines, pyrimidines, nucleosides, and nucleotides:DNA metabolism:Protein fate:Cell envelope:Metabolism:Metabolism:Cell Motility:Biosynthesis of Other Secondary Metabolites:Glycan Biosynthesis and Metabolism:Nucleotide Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Biosynthesis of Other Secondary Metabolites:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Sugars:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:2'-Deoxyribonucleotide metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein modification and repair:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Lipid Metabolism" 269 "Rhodanese-related sulfurtransferase:Rhodanese-related sulfurtransferase:ADP-ribose pyrophosphatase:ADP-ribose pyrophosphatase:Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Peroxiredoxin:Peroxiredoxin:Molybdopterin-guanine dinucleotide biosynthesis protein:Molybdopterin-guanine dinucleotide biosynthesis protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Molybdopterin-binding protein:Molybdopterin-binding protein:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:catalytic activity:peroxidase activity:sugar:hydrogen symporter activity:calcium ion binding:ATP binding:GTP binding:electron transport:DNA recombination:Mo-molybdopterin cofactor biosynthetic process:transport:response to oxidative stress:cell communication:phosphoenolpyruvate-protein phosphotransferase activity:phosphoenolpyruvate-dependent sugar phosphotransferase system:DNA integration:molybdate transmembrane-transporting ATPase activity:antioxidant activity:phosphorylation:oxidoreductase activity:hydrolase activity:heme binding:molybdenum ion binding:cell redox homeostasis:transition metal ion binding:iron-sulfur cluster binding:peroxiredoxin activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Fructose and mannose metabolism:Metabolic pathways:Metabolic pathways:Phosphotransferase system (PTS):Phosphotransferase system (PTS):Function unknown:Function unknown:Mop:Mop:PTS_HPr_family:PTS_HPr_family:Environmental Information Processing:Global:Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Transport and binding proteins:Anions:Signal transduction:PTS:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Signal transduction:Transport and binding proteins:PTS:Anions:Global:Environmental Information Processing:Metabolism:Carbohydrate Metabolism:Metabolism:Membrane Transport:Membrane Transport" 270 "Energy production and conversion:Energy production and conversion:Predicted GTPase, probable translation factor:Predicted GTPase, probable translation factor:Porphobilinogen deaminase:Porphobilinogen deaminase:Nucleotide-binding protein implicated in inhibition of septum formation:Nucleotide-binding protein implicated in inhibition of septum formation:Glycosyltransferase:Glycosyltransferase:ATPase components of ABC transporters with duplicated ATPase domains:ATPase components of ABC transporters with duplicated ATPase domains:IMP dehydrogenase/GMP reductase:IMP dehydrogenase/GMP reductase:Pseudouridylate synthases, 23S RNA-specific:Pseudouridylate synthases, 23S RNA-specific:Type I site-specific restriction-modification system, R (restriction) subunit and related helicases:Type I site-specific restriction-modification system, R (restriction) subunit and related helicases:Glycyl-tRNA synthetase, beta subunit:Glycyl-tRNA synthetase, beta subunit:Glycyl-tRNA synthetase, alpha subunit:Glycyl-tRNA synthetase, alpha subunit:UDP-N-acetylglucosamine enolpyruvyl transferase:UDP-N-acetylglucosamine enolpyruvyl transferase:Cell division protein FtsI/penicillin-binding protein 2:Cell division protein FtsI/penicillin-binding protein 2:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Predicted transcriptional regulators:Predicted transcriptional regulators:Threonine aldolase:Threonine aldolase:NaMN:DMB phosphoribosyltransferase:NaMN:DMB phosphoribosyltransferase:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Uncharacterized protein related to glutamine synthetase:Uncharacterized protein related to glutamine synthetase:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:Cytochrome c biogenesis factor:Cytochrome c biogenesis factor:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):pseudouridine synthesis:DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:GMP reductase activity:IMP dehydrogenase activity:glutamate-ammonia ligase activity:hydroxymethylbilane synthase activity:threonine aldolase activity:arginine-tRNA ligase activity:glycine-tRNA ligase activity:signal transducer activity:binding:ATP binding:GTP binding:electron transport:GMP biosynthetic process:mismatch repair:regulation of transcription, DNA-dependent:arginyl-tRNA aminoacylation:glycyl-tRNA aminoacylation:cellular amino acid metabolic process:glutamine biosynthetic process:nitrogen compound metabolic process:chemotaxis:signal transduction:transcription factor binding:metabolic process:zinc ion binding:penicillin binding:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity:peptidoglycan glycosyltransferase activity:starch synthase activity:Type I site-specific deoxyribonuclease activity:biosynthetic process:cyclic nucleotide biosynthetic process:cobalamin biosynthetic process:peptidoglycan-based cell wall biogenesis:pilus assembly:protein secretion:DNA restriction-modification system:nutrient import:pseudouridine synthase activity:ferrous iron transmembrane transporter activity:ferrous iron transport:phosphorus-oxygen lyase activity:ATPase activity:nucleoside-triphosphatase activity:UDP-N-acetylgalactosamine biosynthetic process:pyridoxal phosphate binding:thiamine pyrophosphate binding:mismatched DNA binding:tetrapyrrole biosynthetic process:intracellular signal transduction:sequence-specific DNA binding:indolepyruvate ferredoxin oxidoreductase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Riboflavin metabolism:Riboflavin metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Nitrogen metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00092:TIGR00092:maf:maf:glyS:glyS:hemC:hemC:sensory_box:sensory_box:hsdR:hsdR:glyQ:glyQ:murA:murA:IMP_dehydrog:IMP_dehydrog:C4_traR_proteo:C4_traR_proteo:IV_pilus_PilQ:IV_pilus_PilQ:cobT_DBIPRT:cobT_DBIPRT:IOR_alpha:IOR_alpha:pbp2_mrdA:pbp2_mrdA:Defense mechanisms:Defense mechanisms:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation:Metabolism of Cofactors and Vitamins:Signal Transduction:Cell Motility:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Cellular Processes:Global:Purine ribonucleotide biosynthesis:Small molecule interactions:Restriction/modification:tRNA aminoacylation:Cell division:Prophage functions:General:Heme, porphyrin, and cobalamin:Biosynthesis and degradation of murein sacculus and peptidoglycan:Surface structures:Purines, pyrimidines, nucleosides, and nucleotides:Regulatory functions:DNA metabolism:Protein synthesis:Cellular processes:Mobile and extrachromosomal element functions:Unknown function:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:Restriction/modification:Protein synthesis:tRNA aminoacylation:Cellular processes:Cell division:Mobile and extrachromosomal element functions:Prophage functions:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan" 271 "Uncharacterized conserved protein:Uncharacterized conserved protein:Methionyl-tRNA formyltransferase:Methionyl-tRNA formyltransferase:Translation elongation factors (GTPases):Translation elongation factors (GTPases):Multidrug resistance efflux pump:Multidrug resistance efflux pump:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:translation elongation factor activity:GTPase activity:biotin-[acetyl-CoA-carboxylase] ligase activity:methionyl-tRNA formyltransferase activity:protein histidine kinase activity:ATP binding:GTP binding:translational elongation:protein modification process:protein-synthesizing GTPase activity:protein transporter activity:biosynthetic process:protein secretion:peptidyl-histidine phosphorylation:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:One carbon pool by folate:One carbon pool by folate:Biotin metabolism:Biotin metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00106:TIGR00106:small_GTP:small_GTP:Defense mechanisms:Defense mechanisms:Information storage and processing:Cellular processes and signaling:Poorly characterized:Translation:Metabolism of Cofactors and Vitamins:Metabolism:Metabolism:Genetic Information Processing:Global:General:Unknown function:Information storage and processing:Cellular processes and signaling:Poorly characterized:Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Global:Metabolism:Unknown function:General" 272 "Energy production and conversion:Energy production and conversion:dsRNA-specific ribonuclease:dsRNA-specific ribonuclease:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Fe-S oxidoreductase:Fe-S oxidoreductase:Transcriptional regulator:Transcriptional regulator:Transcriptional regulators:Transcriptional regulators:FOG: PAS/PAC domain:FOG: PAS/PAC domain:Cation transport ATPase:Cation transport ATPase:Membrane-bound lytic murein transglycosylase B:Membrane-bound lytic murein transglycosylase B:Predicted periplasmic ligand-binding sensor domain:Predicted periplasmic ligand-binding sensor domain:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Predicted membrane protein:Predicted membrane protein:Predicted glycosyltransferase:Predicted glycosyltransferase:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:double-stranded RNA binding:catalytic activity:copper-exporting ATPase activity:ribonuclease III activity:signal transducer activity:ATP binding:regulation of transcription, DNA-dependent:RNA processing:signal transduction:metabolic process:FMN binding:proton transport:rRNA catabolic process:specific transcriptional repressor activity:metal ion transport:cobalamin binding:sequence-specific DNA binding:negative regulation of transcription, DNA-dependent:metal ion binding:iron-sulfur cluster binding:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:ATPase-IB_hvy:ATPase-IB_hvy:RNaseIII:RNaseIII:Cellular processes and signaling:Information storage and processing:RNA processing:Transcription:Transcription:Regulatory functions:RNA processing:Small molecule interactions:Small molecule interactions:Regulatory functions:Poorly characterized:Metabolism:Cellular processes and signaling:Poorly characterized:Information storage and processing:Metabolism" 273 "MoxR-like ATPases:MoxR-like ATPases:Predicted ATPases:Predicted ATPases:DNA binding:ATP binding:chromosome segregation:cyclic nucleotide biosynthetic process:phosphorus-oxygen lyase activity:ATPase activity:chromosome condensation:intracellular signal transduction:cobaltochelatase activity:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:General function prediction only:General function prediction only:GGDEF:GGDEF:Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Signal transduction:Other:Poorly characterized:Metabolism:Metabolism of Cofactors and Vitamins:Metabolism:Global:Other:Signal transduction:Poorly characterized" 274 "Energy production and conversion:Energy production and conversion:Superfamily I DNA and RNA helicases:Superfamily I DNA and RNA helicases:Anaerobic dehydrogenases, typically selenocysteine-containing:Anaerobic dehydrogenases, typically selenocysteine-containing:Lactoylglutathione lyase and related lyases:Lactoylglutathione lyase and related lyases:ABC-type antimicrobial peptide transport system, permease component:ABC-type antimicrobial peptide transport system, permease component:Rhodanese-related sulfurtransferase:Rhodanese-related sulfurtransferase:Chemotaxis protein histidine kinase and related kinases:Chemotaxis protein histidine kinase and related kinases:Multimeric flavodoxin WrbA:Multimeric flavodoxin WrbA:Molybdopterin-guanine dinucleotide biosynthesis protein A:Molybdopterin-guanine dinucleotide biosynthesis protein A:Catalase:Catalase:Nitroreductase:Nitroreductase:FOG: CheY-like receiver:FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Lactate dehydrogenase and related dehydrogenases:Lactate dehydrogenase and related dehydrogenases:Peroxiredoxin:Peroxiredoxin:NADH dehydrogenase, FAD-containing subunit:NADH dehydrogenase, FAD-containing subunit:Methylase of chemotaxis methyl-accepting proteins:Methylase of chemotaxis methyl-accepting proteins:Chemotaxis protein; stimulates methylation of MCP proteins:Chemotaxis protein; stimulates methylation of MCP proteins:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:Bacterioferritin (cytochrome b1):Bacterioferritin (cytochrome b1):Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Putative NADPH-quinone reductase (modulator of drug activity B):Putative NADPH-quinone reductase (modulator of drug activity B):Cytochrome c553:Cytochrome c553:Uncharacterized protein involved in formate dehydrogenase formation:Uncharacterized protein involved in formate dehydrogenase formation:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:catalytic activity:NADH dehydrogenase activity:ATP-dependent DNA helicase activity:catalase activity:phosphoglycerate dehydrogenase activity:protein histidine kinase activity:signal transducer activity:iron ion binding:ATP binding:electron transport:DNA repair:regulation of transcription, DNA-dependent:cellular aromatic compound metabolic process:Mo-molybdopterin cofactor biosynthetic process:iron ion transport:cellular iron ion homeostasis:chemotaxis:response to oxidative stress:signal transduction:metabolic process:ferrous iron binding:ferric iron binding:formate dehydrogenase (NAD+) activity:gluconate 2-dehydrogenase activity:protein-glutamate O-methyltransferase activity:protein-glutamate methylesterase activity:electron carrier activity:antioxidant activity:oxidoreductase activity:isomerase activity:peptidyl-histidine phosphorylation:heme binding:molybdenum ion binding:cellular respiration:cell redox homeostasis:transition metal ion binding:protein-glutamine glutaminase activity:flavin adenine dinucleotide binding:coenzyme binding:NAD binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Tryptophan metabolism:Tryptophan metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:TAT_signal_seq:TAT_signal_seq:Nterm_to_SelD:Nterm_to_SelD:Defense mechanisms:Defense mechanisms:Energy Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Carbohydrate Metabolism:Protein fate:Protein and peptide secretion and trafficking:Global:Cellular Processes:Environmental Information Processing:Metabolism:Amino Acid Metabolism:Metabolism:Cell Motility:Signal Transduction:Cell Motility:Global:Metabolism:Cellular Processes:Energy Metabolism:Protein fate:Protein and peptide secretion and trafficking:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Signal Transduction:Environmental Information Processing:Amino Acid Metabolism" 275 "Prolyl-tRNA synthetase:Prolyl-tRNA synthetase:Branched-chain amino acid ABC-type transport system, permease components:Branched-chain amino acid ABC-type transport system, permease components:Holliday junction resolvasome, DNA-binding subunit:Holliday junction resolvasome, DNA-binding subunit:Fe2+/Zn2+ uptake regulation proteins:Fe2+/Zn2+ uptake regulation proteins:ABC-type metal ion transport system, periplasmic component/surface adhesin:ABC-type metal ion transport system, periplasmic component/surface adhesin:ABC-type Mn2+/Zn2+ transport systems, permease components:ABC-type Mn2+/Zn2+ transport systems, permease components:ABC-type Mn/Zn transport systems, ATPase component:ABC-type Mn/Zn transport systems, ATPase component:Deoxyxylulose-5-phosphate synthase:Deoxyxylulose-5-phosphate synthase:Exonuclease VII small subunit:Exonuclease VII small subunit:Tfp pilus assembly protein, pilus retraction ATPase PilT:Tfp pilus assembly protein, pilus retraction ATPase PilT:Predicted integral membrane protein:Predicted integral membrane protein:Amino acid transport and metabolism:Amino acid transport and metabolism:sequence-specific DNA binding transcription factor activity:glutamate-tRNA ligase activity:glutamine-tRNA ligase activity:proline-tRNA ligase activity:transporter activity:binding:ATP binding:DNA repair:DNA catabolic process:DNA recombination:regulation of transcription, DNA-dependent:glutamyl-tRNA aminoacylation:glutaminyl-tRNA aminoacylation:prolyl-tRNA aminoacylation:proteolysis:transport:cell cycle:peptidase activity:1-deoxy-D-xylulose-5-phosphate synthase activity:exodeoxyribonuclease VII activity:four-way junction helicase activity:terpenoid biosynthetic process:ATPase activity:nucleoside-triphosphatase activity:thiamine pyrophosphate binding:ATPase activity, coupled to transmembrane movement of substances:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:Function unknown:Function unknown:dxs:dxs:proS_fam_II:proS_fam_II:pilT_fam:pilT_fam:queuosine_YadB:queuosine_YadB:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Environmental Information Processing:Membrane Transport:Metabolism of Cofactors and Vitamins:Global:Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Cellular processes:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Cellular processes:Protein synthesis:Thiamine:Chemotaxis and motility:tRNA and rRNA base modification:tRNA aminoacylation:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Translation:Replication and Repair:Translation:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Membrane Transport:Replication and Repair:Genetic Information Processing:Metabolism of Terpenoids and Polyketides" 276 "Energy production and conversion:Energy production and conversion:Nitrogen regulatory protein PII:Nitrogen regulatory protein PII:Predicted amidohydrolase:Predicted amidohydrolase:Nitrogenase molybdenum-iron protein, alpha and beta chains:Nitrogenase molybdenum-iron protein, alpha and beta chains:Molybdenum cofactor biosynthesis enzyme:Molybdenum cofactor biosynthesis enzyme:Ferredoxin:Ferredoxin:Mu-like prophage tail protein gpP:Mu-like prophage tail protein gpP:Mu-like prophage protein gp36:Mu-like prophage protein gp36:Mu-like prophage I protein:Mu-like prophage I protein:Mu-like prophage major head subunit gpT:Mu-like prophage major head subunit gpT:Amino acid transport and metabolism:Amino acid transport and metabolism:catalytic activity:amidase activity:formamidase activity:protein binding:electron transport:protein complex assembly:nitrogen compound metabolic process:regulation of nitrogen utilization:metabolic process:nitrogen fixation:nitrogenase activity:iron-iron nitrogenase activity:molybdenum-iron nitrogenase activity:vanadium-iron nitrogenase activity:enzyme regulator activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Nitrogen metabolism:Nitrogen metabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:nifE:nifE:Carbohydrate Metabolism:Central intermediary metabolism:Metabolism:Central intermediary metabolism:Nitrogen fixation:Metabolism:Energy Metabolism:Carbohydrate Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Metabolism:Nitrogen fixation:Poorly characterized" 277 "Energy production and conversion:Energy production and conversion:N-methylhydantoinase A/acetone carboxylase, beta subunit:N-methylhydantoinase A/acetone carboxylase, beta subunit:Glycogen synthase:Glycogen synthase:ABC-type uncharacterized transport system, permease component:ABC-type uncharacterized transport system, permease component:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:Glycosyltransferases involved in cell wall biogenesis:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases:Predicted permease:Predicted permease:Signal transduction histidine kinase:Signal transduction histidine kinase:Predicted nucleoside-diphosphate-sugar epimerases:Predicted nucleoside-diphosphate-sugar epimerases:dTDP-D-glucose 4,6-dehydratase:dTDP-D-glucose 4,6-dehydratase:dTDP-4-dehydrorhamnose reductase:dTDP-4-dehydrorhamnose reductase:Fe-S-cluster-containing hydrogenase components 2:Fe-S-cluster-containing hydrogenase components 2:Putative threonine efflux protein:Putative threonine efflux protein:Methylase of chemotaxis methyl-accepting proteins:Methylase of chemotaxis methyl-accepting proteins:Predicted dioxygenase:Predicted dioxygenase:Alcohol dehydrogenase, class IV:Alcohol dehydrogenase, class IV:Beta-glucosidase-related glycosidases:Beta-glucosidase-related glycosidases:Predicted signal transduction protein:Predicted signal transduction protein:Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase:Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase:Uncharacterized protein involved in outer membrane biogenesis:Uncharacterized protein involved in outer membrane biogenesis:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Uncharacterized metal-binding protein:Uncharacterized metal-binding protein:Kef-type K+ transport system, predicted NAD-binding component:Kef-type K+ transport system, predicted NAD-binding component:Predicted rRNA methylase:Predicted rRNA methylase:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):catalytic activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:protein histidine kinase activity:ATP binding:carbohydrate metabolic process:glycogen biosynthetic process:electron transport:regulation of transcription, DNA-dependent:proteolysis:potassium ion transport:amino acid transport:regulation of pH:chemotaxis:signal transduction:metabolic process:metallopeptidase activity:dTDP-glucose 4,6-dehydratase activity:cobinamide phosphate guanylyltransferase activity:dTDP-4-dehydrorhamnose reductase activity:formate dehydrogenase (NAD+) activity:protein-glutamate O-methyltransferase activity:starch synthase activity:succinyl-diaminopimelate desuccinylase activity:electron carrier activity:nucleotide-sugar metabolic process:glucan biosynthetic process:solute:hydrogen antiporter activity:beta-N-acetylglucosaminidase activity:oxidoreductase activity:hydrolase activity:peptidyl-histidine phosphorylation:pyridoxal phosphate binding:adenosylcobinamide kinase activity:cellular metabolic process:extracellular polysaccharide biosynthetic process:metal ion binding:protein dimerization activity:coenzyme binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Polyketide sugar unit biosynthesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:TIGR00245:TIGR00245:dTDP_gluc_dehyt:dTDP_gluc_dehyt:rmlD:rmlD:glgA:glgA:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Biosynthesis of Other Secondary Metabolites:Signal Transduction:Cell Motility:Metabolism:Metabolism:Environmental Information Processing:Cellular Processes:Global:Biosynthesis and degradation of polysaccharides:Small molecule interactions:Conserved:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Energy metabolism:Regulatory functions:Hypothetical proteins:Cell envelope:Metabolism of Cofactors and Vitamins:Carbohydrate Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Regulatory functions:Small molecule interactions:Hypothetical proteins:Conserved:Cell envelope:Metabolism of Terpenoids and Polyketides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 278 "Energy production and conversion:Energy production and conversion:Undecaprenyl pyrophosphate synthase:Undecaprenyl pyrophosphate synthase:Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase):Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase):Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Dihydroorotase and related cyclic amidohydrolases:Dihydroorotase and related cyclic amidohydrolases:Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases:Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases:Peptidyl-tRNA hydrolase:Peptidyl-tRNA hydrolase:FAD synthase:FAD synthase:Aspartate/tyrosine/aromatic aminotransferase:Aspartate/tyrosine/aromatic aminotransferase:Glycosyltransferase:Glycosyltransferase:Exoribonuclease R:Exoribonuclease R:Predicted phosphoesterase:Predicted phosphoesterase:FOG: CheY-like receiver:FOG: CheY-like receiver:Glutamate racemase:Glutamate racemase:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Na+/alanine symporter:Na+/alanine symporter:Ferredoxin:Ferredoxin:4-diphosphocytidyl-2-methyl-D-erithritol synthase:4-diphosphocytidyl-2-methyl-D-erithritol synthase:Predicted hydrolases of HD superfamily:Predicted hydrolases of HD superfamily:Pyridoxal/pyridoxine/pyridoxamine kinase:Pyridoxal/pyridoxine/pyridoxamine kinase:ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase:ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase:Methylase of polypeptide chain release factors:Methylase of polypeptide chain release factors:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Predicted methyltransferase:Predicted methyltransferase:Peptide chain release factor RF-3:Peptide chain release factor RF-3:Bacteriophage capsid protein:Bacteriophage capsid protein:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:RNA binding:catalytic activity:FMN adenylyltransferase activity:GTPase activity:allantoinase activity:amidase activity:aminoacyl-tRNA hydrolase activity:L-aspartate:2-oxoglutarate aminotransferase activity:dihydroorotase activity:phosphatidylserine decarboxylase activity:sodium:amino acid symporter activity:ATP binding:GTP binding:electron transport:regulation of transcription, DNA-dependent:translation:translational termination:glutamyl-tRNA aminoacylation:aminoacyl-tRNA hydrolase reaction:protein methylation:sodium ion transport:tRNA processing:metabolic process:5'-nucleotidase activity:protein methyltransferase activity:pyridoxal kinase activity:riboflavin kinase activity:protein-synthesizing GTPase activity:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity:di-trans,poly-cis-decaprenylcistransferase activity:exoribonuclease II activity:glutamate racemase activity:electron carrier activity:biosynthetic process:purine base biosynthetic process:riboflavin biosynthetic process:peptidoglycan biosynthetic process:terpenoid biosynthetic process:translation release factor activity, codon specific:hydroxymethyl-, formyl- and related transferase activity:hydrolase activity:1-aminocyclopropane-1-carboxylate synthase activity:IMP-GMP specific 5'-nucleotidase activity:pyridoxal phosphate binding:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Tyrosine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Novobiocin biosynthesis:D-Glutamine and D-glutamate metabolism:D-Glutamine and D-glutamate metabolism:One carbon pool by folate:One carbon pool by folate:Riboflavin metabolism:Riboflavin metabolism:Vitamin B6 metabolism:Vitamin B6 metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:yfcE:yfcE:uppS:uppS:glut_race:glut_race:ribF:ribF:gatA:gatA:ispF:ispF:small_GTP:small_GTP:TIGR00423:TIGR00423:pth:pth:hemK_fam:hemK_fam:agcS:agcS:pyrC_multi:pyrC_multi:purT:purT:portal_lambda:portal_lambda:Nucleotide Metabolism:Global:Mobile and extrachromosomal element functions:Pyrimidine ribonucleotide biosynthesis:Other:tRNA aminoacylation:Protein modification and repair:Prophage functions:Conserved:Enzymes of unknown specificity:General:Other:Riboflavin, FMN, and FAD:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Purines, pyrimidines, nucleosides, and nucleotides:Protein synthesis:Protein fate:Mobile and extrachromosomal element functions:Hypothetical proteins:Unknown function:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Genetic Information Processing:Metabolism:Metabolism:Translation:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:Protein synthesis:Other:tRNA aminoacylation:Protein fate:Protein modification and repair:Purine ribonucleotide biosynthesis:Prophage functions:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Riboflavin, FMN, and FAD:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Amino Acid Metabolism" 279 "Energy production and conversion:Energy production and conversion:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Acetyltransferases:Acetyltransferases:Transcriptional regulator:Transcriptional regulator:6-pyruvoyl-tetrahydropterin synthase:6-pyruvoyl-tetrahydropterin synthase:Transcriptional regulator:Transcriptional regulator:Isopentenyldiphosphate isomerase:Isopentenyldiphosphate isomerase:Membrane transporters of cations and cationic drugs:Membrane transporters of cations and cationic drugs:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Thiol:disulfide interchange protein:Thiol:disulfide interchange protein:Mu-like prophage protein gp46:Mu-like prophage protein gp46:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:6-pyruvoyltetrahydropterin synthase activity:acetate-CoA ligase activity:isopentenyl-diphosphate delta-isomerase activity:iron ion binding:ATP binding:electron transport:transcription initiation, DNA-dependent:regulation of transcription, DNA-dependent:N-terminal protein amino acid acetylation:glycerol ether metabolic process:transcription factor binding:metabolic process:isoprenoid biosynthetic process:ribosomal-protein-alanine N-acetyltransferase activity:electron carrier activity:protein disulfide oxidoreductase activity:DNA integration:AMP binding:specific transcriptional repressor activity:hydrolase activity:ligase activity, forming carbon-sulfur bonds:sigma factor activity:cytochrome complex assembly:nucleoside-triphosphatase activity:isopentenyl diphosphate biosynthetic process, mevalonate pathway:heme binding:ribosome biogenesis:sequence-specific DNA binding:cell redox homeostasis:negative regulation of transcription, DNA-dependent:protein-disulfide reductase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Methane metabolism:Methane metabolism:Folate biosynthesis:Folate biosynthesis:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:HDIG:HDIG:rimI:rimI:Ac_CoA_lig_AcsA:Ac_CoA_lig_AcsA:queuosine_QueD:queuosine_QueD:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins:Energy Metabolism:Carbohydrate Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Metabolism of Terpenoids and Polyketides:Energy Metabolism:Protein synthesis:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification:Global:Metabolism:Metabolism:Global:Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Protein synthesis:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification" 280 "Energy production and conversion:Energy production and conversion:Glutamate synthase domain 2:Glutamate synthase domain 2:3-oxoacyl-(acyl-carrier-protein) synthase:3-oxoacyl-(acyl-carrier-protein) synthase:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:Putative GTPases (G3E family):Putative GTPases (G3E family):Transcriptional regulator:Transcriptional regulator:Predicted permeases:Predicted permeases:Cell division protein FtsI/penicillin-binding protein 2:Cell division protein FtsI/penicillin-binding protein 2:Biopolymer transport proteins:Biopolymer transport proteins:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Biopolymer transport protein:Biopolymer transport protein:Metal-dependent hydrolases of the beta-lactamase superfamily II:Metal-dependent hydrolases of the beta-lactamase superfamily II:L-lactate permease:L-lactate permease:Uncharacterized protein conserved in archaea:Uncharacterized protein conserved in archaea:Transcriptional regulators:Transcriptional regulators:Predicted membrane protein:Predicted membrane protein:Amino acid transport and metabolism:Amino acid transport and metabolism:fatty-acyl-CoA binding:two-component sensor activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:catalytic activity:amidophosphoribosyltransferase activity:glutamate synthase (NADPH) activity:transporter activity:electron transport:regulation of transcription, DNA-dependent:glutamate biosynthetic process:transport:chemotaxis:metabolic process:protein transporter activity:penicillin binding:peptidoglycan glycosyltransferase activity:electron carrier activity:biosynthetic process:purine base biosynthetic process:peptidoglycan-based cell wall biogenesis:lactate transmembrane transporter activity:lactate transport:glutamate synthase (NADH) activity:oxidoreductase activity:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:transferase activity:hydrolase activity:regulation of fatty acid metabolic process:cofactor binding:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Fatty acid biosynthesis:Fatty acid biosynthesis:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:lctP:lctP:TAT_signal_seq:TAT_signal_seq:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Global:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Metabolism:Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Transport and binding proteins:Protein fate:Carbohydrates, organic alcohols, and acids:Protein and peptide secretion and trafficking:Global:Metabolism:Metabolism:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Poorly characterized:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Information storage and processing:Cellular processes and signaling:Metabolism" 281 "Energy production and conversion:Energy production and conversion:Malate/lactate dehydrogenases:Malate/lactate dehydrogenases:Signal transduction histidine kinase:Signal transduction histidine kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Molybdopterin-guanine dinucleotide biosynthesis protein A:Molybdopterin-guanine dinucleotide biosynthesis protein A:Uncharacterized protein required for formate dehydrogenase activity:Uncharacterized protein required for formate dehydrogenase activity:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Molybdenum cofactor biosynthesis enzyme:Molybdenum cofactor biosynthesis enzyme:Uncharacterized protein involved in formate dehydrogenase formation:Uncharacterized protein involved in formate dehydrogenase formation:Putative regulator of cell autolysis:Putative regulator of cell autolysis:Response regulator of the LytR/AlgR family:Response regulator of the LytR/AlgR family:Signal transduction histidine kinase regulating citrate/malate metabolism:Signal transduction histidine kinase regulating citrate/malate metabolism:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase:Signal transduction histidine kinase:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:L-lactate dehydrogenase activity:ATP binding:glycolysis:tricarboxylic acid cycle intermediate metabolic process:electron transport:regulation of transcription, DNA-dependent:Mo-molybdopterin cofactor biosynthetic process:cellular cell wall organization:signal transduction:transcription factor binding:formate dehydrogenase (NAD+) activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:metal ion binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Sulfur relay system:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:unchar_dom_1:unchar_dom_1:L-LDH-NAD:L-LDH-NAD:moaA:moaA:Folding Sorting and Degradation:Amino Acid Metabolism:Carbohydrate Metabolism:Global:Environmental Information Processing:Glycolysis/gluconeogenesis:Small molecule interactions:Molybdopterin:Energy metabolism:Regulatory functions:Biosynthesis of cofactors, prosthetic groups, and carriers:Genetic Information Processing:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Regulatory functions:Small molecule interactions:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Signal Transduction" 282 "Cysteinyl-tRNA synthetase:Cysteinyl-tRNA synthetase:Preprotein translocase subunit SecF:Preprotein translocase subunit SecF:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:NAD/FAD-utilizing enzyme apparently involved in cell division:NAD/FAD-utilizing enzyme apparently involved in cell division:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):Predicted permeases:Predicted permeases:Actin-like ATPase involved in cell morphogenesis:Actin-like ATPase involved in cell morphogenesis:N-acetylglutamate synthase and related acetyltransferases:N-acetylglutamate synthase and related acetyltransferases:Lauroyl/myristoyl acyltransferase:Lauroyl/myristoyl acyltransferase:Uroporphyrinogen-III synthase:Uroporphyrinogen-III synthase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Flp pilus assembly protein TadD, contains TPR repeats:Flp pilus assembly protein TadD, contains TPR repeats:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:cell morphogenesis:nucleic acid binding:sequence-specific DNA binding transcription factor activity:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:acetyl-CoA:L-glutamate N-acetyltransferase activity:cysteine-tRNA ligase activity:uroporphyrin-III C-methyltransferase activity:uroporphyrinogen-III synthase activity:binding:ATP binding:nucleobase-containing compound metabolic process:transcription initiation, DNA-dependent:regulation of transcription, DNA-dependent:RNA processing:cysteinyl-tRNA aminoacylation:porphyrin-containing compound biosynthetic process:intracellular protein transport:tRNA processing:metabolic process:3'-5' exonuclease activity:lipopolysaccharide core region biosynthetic process:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:protein secretion by the type II secretion system:transferase activity, transferring acyl groups:ATPase activity:sigma factor activity:flavin adenine dinucleotide binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Arginine and proline metabolism:Arginine and proline metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:RNA polymerase:RNA polymerase:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Function unknown:Function unknown:gidA:gidA:cysS:cysS:mreB:mreB:3a0501s07:3a0501s07:cobA_cysG_Cterm:cobA_cysG_Cterm:sigma70-ECF:sigma70-ECF:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Amino Acid Metabolism:Membrane Transport:Folding Sorting and Degradation:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:tRNA aminoacylation:tRNA and rRNA base modification:Protein and peptide secretion and trafficking:Heme, porphyrin, and cobalamin:Biosynthesis and degradation of murein sacculus and peptidoglycan:Protein synthesis:Protein fate:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Translation:Transcription:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking" 283 "Energy production and conversion:Energy production and conversion:Acetyltransferase (isoleucine patch superfamily):Acetyltransferase (isoleucine patch superfamily):Putative translation initiation inhibitor, yjgF family:Putative translation initiation inhibitor, yjgF family:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Predicted glycosyltransferases:Predicted glycosyltransferases:NADH dehydrogenase, FAD-containing subunit:NADH dehydrogenase, FAD-containing subunit:Transcriptional accessory protein:Transcriptional accessory protein:Predicted transcriptional regulator:Predicted transcriptional regulator:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:two-component sensor activity:two-component signal transduction system (phosphorelay):nucleotide binding:DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:NADH dehydrogenase activity:polyribonucleotide nucleotidyltransferase activity:signal transducer activity:nucleobase-containing compound metabolic process:regulation of transcription, DNA-dependent:chemotaxis:signal transduction:cyclic nucleotide biosynthetic process:DNA integration:oxidoreductase activity:transcription repressor activity:transferase activity, transferring acyl groups:hydrolase activity, acting on ester bonds:phosphorus-oxygen lyase activity:intracellular signal transduction:negative regulation of transcription, DNA-dependent:transition metal ion binding:flavin adenine dinucleotide binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell motility:Cell motility:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:excise:excise:Nterm_to_SelD:Nterm_to_SelD:Small molecule interactions:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Regulatory functions:General:Unknown function:Cellular processes and signaling:Small molecule interactions:Information storage and processing:Cellular Processes:Environmental Information Processing:Cell Motility:Signal Transduction:Signal Transduction:Environmental Information Processing:Poorly characterized:Cellular Processes:Cell Motility:Metabolism:Regulatory functions" 284 "Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:FOG: TPR repeat, SEL1 subfamily:FOG: TPR repeat, SEL1 subfamily:Recombinational DNA repair protein (RecF pathway):Recombinational DNA repair protein (RecF pathway):L-serine deaminase:L-serine deaminase:Tryptophanase:Tryptophanase:ABC-type molybdate transport system, permease component:ABC-type molybdate transport system, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:L-serine ammonia-lyase activity:coproporphyrinogen oxidase activity:binding:ATP binding:gluconeogenesis:DNA repair:DNA recombination:porphyrin-containing compound biosynthetic process:pyruvate, water dikinase activity:tryptophanase activity:aromatic amino acid family metabolic process:molybdate ion transmembrane transporter activity:molybdate ion transport:phosphorylation:pyridoxal phosphate binding:regulation of GTPase activity:iron-sulfur cluster binding:coproporphyrinogen dehydrogenase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Tryptophan metabolism:Tryptophan metabolism:Pyruvate metabolism:Pyruvate metabolism:Methane metabolism:Methane metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:hemN_rel:hemN_rel:reco:reco:sda_mono:sda_mono:modB_ABC:modB_ABC:Amino Acid Metabolism:Metabolism:Metabolism:Membrane Transport:Metabolism of Cofactors and Vitamins:Replication and Repair:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Metabolism of Cofactors and Vitamins:Transport and binding proteins:Glycolysis/gluconeogenesis:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Anions:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Metabolism:Poorly characterized:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism:Energy metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:DNA metabolism:Energy metabolism:Heme, porphyrin, and cobalamin:Anions:DNA replication, recombination, and repair:Information storage and processing:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Glycolysis/gluconeogenesis:Energy Metabolism:Global:Environmental Information Processing:Nucleotide Metabolism:Genetic Information Processing" 285 "Energy production and conversion:Energy production and conversion:Lactoylglutathione lyase and related lyases:Lactoylglutathione lyase and related lyases:Glycosyltransferase:Glycosyltransferase:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:Predicted permeases:Predicted permeases:FOG: CheY-like receiver:FOG: CheY-like receiver:Acyl-CoA synthetase (NDP forming):Acyl-CoA synthetase (NDP forming):Predicted membrane protein, hemolysin III homolog:Predicted membrane protein, hemolysin III homolog:Uncharacterized conserved protein:Uncharacterized conserved protein:FOG: PAS/PAC domain:FOG: PAS/PAC domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Response regulator of citrate/malate metabolism:Response regulator of citrate/malate metabolism:Response regulator:Response regulator:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:lactoylglutathione lyase activity:purine-nucleoside phosphorylase activity:succinate-CoA ligase (ADP-forming) activity:signal transducer activity:transporter activity:ATP binding:regulation of transcription, DNA-dependent:protein folding:transport:signal transduction:N-acetyltransferase activity:transcription factor binding:metabolic process:isoprenoid biosynthetic process:protein transport:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:cytolysis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Metabolic pathways:Metabolic pathways:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:hlyIII:hlyIII:Poorly characterized:Global:Glycan Biosynthesis and Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Metabolism:Regulatory functions:Small molecule interactions:Global:Metabolism:Metabolism:Glycan Biosynthesis and Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Regulatory functions:Small molecule interactions:Metabolism" 286 "Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Flagellar biosynthesis pathway, component FlhA:Flagellar biosynthesis pathway, component FlhA:Uncharacterized flagellar protein FlaG:Uncharacterized flagellar protein FlaG:Flagellar biosynthesis pathway, component FliP:Flagellar biosynthesis pathway, component FliP:Flagellin and related hook-associated proteins:Flagellin and related hook-associated proteins:Flagellar biosynthesis pathway, component FliR:Flagellar biosynthesis pathway, component FliR:Flagellar hook protein FlgE:Flagellar hook protein FlgE:Flagellar hook capping protein:Flagellar hook capping protein:Flagellar biosynthesis pathway, component FliQ:Flagellar biosynthesis pathway, component FliQ:FOG: GGDEF domain:FOG: GGDEF domain:Tfp pilus assembly protein PilF:Tfp pilus assembly protein PilF:Flagellar biogenesis protein:Flagellar biogenesis protein:ciliary or flagellar motility:motor activity:triglyceride lipase activity:signal transducer activity:structural molecule activity:binding:protein targeting:chemotaxis:signal transduction:metabolic process:methyltransferase activity:cyclic nucleotide biosynthetic process:flagellum assembly:protein secretion:protein transport:phosphorus-oxygen lyase activity:intracellular signal transduction:flagellum organization:Cell motility:Cell motility:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Signal transduction mechanisms:Signal transduction mechanisms:GGDEF:GGDEF:fliP:fliP:FlhA:FlhA:fliR:fliR:fliQ:fliQ:FliO_TIGR:FliO_TIGR:FlgEFG_subfam:FlgEFG_subfam:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Other:Cellular processes and signaling:Cellular Processes:Signal Transduction:Cell Motility:Signal Transduction:Environmental Information Processing:Cellular Processes:Cellular processes and signaling:Signal transduction:Cellular processes:Other:Chemotaxis and motility:Environmental Information Processing:Cell Motility:Cellular processes:Chemotaxis and motility:Signal transduction" 287 "Diaminopimelate decarboxylase:Diaminopimelate decarboxylase:Peptide methionine sulfoxide reductase:Peptide methionine sulfoxide reductase:DnaJ-class molecular chaperone with C-terminal Zn finger domain:DnaJ-class molecular chaperone with C-terminal Zn finger domain:Thioredoxin reductase:Thioredoxin reductase:Transcriptional regulator of heat shock gene:Transcriptional regulator of heat shock gene:Flagellar basal body rod protein:Flagellar basal body rod protein:Predicted membrane-bound metal-dependent hydrolases:Predicted membrane-bound metal-dependent hydrolases:Uncharacterized conserved protein:Uncharacterized conserved protein:Copper chaperone:Copper chaperone:Amino acid transport and metabolism:Amino acid transport and metabolism:ciliary or flagellar motility:motor activity:thioredoxin-disulfide reductase activity:structural molecule activity:copper ion transmembrane transporter activity:copper ion binding:electron transport:regulation of transcription, DNA-dependent:protein folding:copper ion transport:peptide-methionine-(S)-S-oxide reductase activity:disulfide oxidoreductase activity:carbon-carbon lyase activity:protein metabolic process:heat shock protein binding:nor-spermidine biosynthetic process:unfolded protein binding:Transcription:Transcription:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Flagellar assembly:Flagellar assembly:General function prediction only:General function prediction only:Function unknown:Function unknown:hrcA:hrcA:msrA:msrA:nspC:nspC:Adaptations to atypical conditions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Adaptations to atypical conditions:DNA interactions:Polyamine biosynthesis:Cellular Processes:Metabolism:Cell Motility:Amino Acid Metabolism:Nucleotide Metabolism:Regulatory functions:Cellular processes:Central intermediary metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Cellular Processes:Cell Motility:Central intermediary metabolism:Polyamine biosynthesis:Regulatory functions:DNA interactions:Cellular processes" 288 "Energy production and conversion:Energy production and conversion:Alanyl-tRNA synthetase:Alanyl-tRNA synthetase:Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase:Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase:FAD/FMN-containing dehydrogenases:FAD/FMN-containing dehydrogenases:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:ABC-type polysaccharide/polyol phosphate transport system, ATPase component:ABC-type polysaccharide/polyol phosphate transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family:Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family:Long-chain fatty acid transport protein:Long-chain fatty acid transport protein:Multiple antibiotic transporter:Multiple antibiotic transporter:ABC-type arginine/histidine transport system, permease component:ABC-type arginine/histidine transport system, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:histidine biosynthetic process:polysaccharide biosynthetic process:nucleic acid binding:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity:alkaline phosphatase activity:dolichyl-phosphate beta-D-mannosyltransferase activity:alanine-tRNA ligase activity:transporter activity:electron transporter activity:copper ion binding:ATP binding:electron transport:alanyl-tRNA aminoacylation:transport:sulfotransferase activity:metabolic process:methyltransferase activity:glycolate oxidase activity:electron carrier activity:FMN binding:peptide transporter activity:nickel-transporting ATPase activity:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:peptide transport:oxidoreductase activity:ATPase activity:flavin adenine dinucleotide binding:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Histidine metabolism:Histidine metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00007:TIGR00007:alaS:alaS:TIGR00427:TIGR00427:HEQRo_perm_3TM:HEQRo_perm_3TM:oligo_HPY:oligo_HPY:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Amino acids, peptides and amines:Unknown function:General:Amino acid biosynthesis:Histidine family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Amino acid biosynthesis:Unknown function:Transport and binding proteins:Protein synthesis:Histidine family:General:Amino acids, peptides and amines:tRNA aminoacylation:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Amino Acid Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Translation:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Membrane Transport:Protein synthesis:tRNA aminoacylation:Transport and binding proteins" 289 "Glutamate synthase domain 1:Glutamate synthase domain 1:Glutamate synthase domain 2:Glutamate synthase domain 2:Glutamate synthase domain 3:Glutamate synthase domain 3:Glycosyltransferase:Glycosyltransferase:Chemotaxis protein histidine kinase and related kinases:Chemotaxis protein histidine kinase and related kinases:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:FOG: CheY-like receiver:FOG: CheY-like receiver:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains):ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains):Predicted transcriptional regulators:Predicted transcriptional regulators:Transcriptional regulators:Transcriptional regulators:Plasmid maintenance system antidote protein:Plasmid maintenance system antidote protein:ABC-type branched-chain amino acid transport system, permease component:ABC-type branched-chain amino acid transport system, permease component:Site-specific recombinase XerC:Site-specific recombinase XerC:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA-directed DNA polymerase activity:ATP-dependent DNA helicase activity:glutamate synthase (NADPH) activity:protein histidine kinase activity:signal transducer activity:transporter activity:ATP binding:electron transport:DNA replication:DNA repair:DNA recombination:regulation of transcription, DNA-dependent:glutamate biosynthetic process:transport:chemotaxis:signal transduction:metabolic process:electron carrier activity:biosynthetic process:DNA integration:glutamate synthase (NADH) activity:kinase activity:peptidyl-histidine phosphorylation:sequence-specific DNA binding:iron-sulfur cluster binding:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:antidote_HigA:antidote_HigA:Information storage and processing:Other:Mobile and extrachromosomal element functions:Environmental Information Processing:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Mobile and extrachromosomal element functions:Other:Cellular Processes:Cellular processes and signaling:Metabolism:Poorly characterized:Cell Motility:Signal Transduction:Membrane Transport" 290 "HD superfamily phosphohydrolases:HD superfamily phosphohydrolases:Predicted transcriptional regulator:Predicted transcriptional regulator:Uncharacterized conserved protein:Uncharacterized conserved protein:DNA binding:catalytic activity:endonuclease activity:DNA modification:response to osmotic stress:transcription repressor activity:transferase activity, transferring acyl groups other than amino-acyl groups:sequence-specific DNA binding:negative regulation of transcription, DNA-dependent:Transcription:Transcription:General function prediction only:General function prediction only:Function unknown:Function unknown:Poorly characterized:Poorly characterized:Information storage and processing:Information storage and processing" 291 "Energy production and conversion:Energy production and conversion:tRNA and rRNA cytosine-C5-methylases:tRNA and rRNA cytosine-C5-methylases:Fe-S oxidoreductase:Fe-S oxidoreductase:FAD/FMN-containing dehydrogenases:FAD/FMN-containing dehydrogenases:Lipoate synthase:Lipoate synthase:Predicted integral membrane protein:Predicted integral membrane protein:Homoserine dehydrogenase:Homoserine dehydrogenase:Anthranilate/para-aminobenzoate synthases component II:Anthranilate/para-aminobenzoate synthases component II:Signal transduction histidine kinase:Signal transduction histidine kinase:Sulfate permease and related transporters (MFS superfamily):Sulfate permease and related transporters (MFS superfamily):tmRNA-binding protein:tmRNA-binding protein:6-pyruvoyl-tetrahydropterin synthase:6-pyruvoyl-tetrahydropterin synthase:ADP-ribose pyrophosphatase:ADP-ribose pyrophosphatase:Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Ni,Fe-hydrogenase I small subunit:Ni,Fe-hydrogenase I small subunit:ATP:corrinoid adenosyltransferase:ATP:corrinoid adenosyltransferase:FOG: PAS/PAC domain:FOG: PAS/PAC domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Precorrin-4 methylase:Precorrin-4 methylase:Nucleoside 2-deoxyribosyltransferase:Nucleoside 2-deoxyribosyltransferase:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Predicted transcriptional regulator:Predicted transcriptional regulator:Predicted dienelactone hydrolase:Predicted dienelactone hydrolase:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:rRNA modification:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:6-pyruvoyltetrahydropterin synthase activity:anthranilate synthase activity:homoserine dehydrogenase activity:signal transducer activity:transporter activity:sugar:hydrogen symporter activity:ATP binding:electron transport:mitochondrial electron transport, NADH to ubiquinone:regulation of transcription, DNA-dependent:RNA processing:translation:glutamine metabolic process:transport:signal transduction:transcription factor binding:NADH dehydrogenase (ubiquinone) activity:RNA methyltransferase activity:rRNA methyltransferase activity:cellular amino acid biosynthetic process:cob(I)yrinic acid a,c-diamide adenosyltransferase activity:glycolate oxidase activity:ferredoxin hydrogenase activity:phosphoenolpyruvate-protein phosphotransferase activity:protein-glutamate methylesterase activity:electron carrier activity:biosynthetic process:lipoate biosynthetic process:cyclic nucleotide biosynthetic process:cobalamin biosynthetic process:phosphoenolpyruvate-dependent sugar phosphotransferase system:phosphorylation:amino acid binding:hydrolase activity:phosphorus-oxygen lyase activity:lipoate synthase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:hydrogenase (acceptor) activity:intracellular signal transduction:precorrin-4 C11-methyltransferase activity:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Lysine biosynthesis:Histidine metabolism:Histidine metabolism:Tyrosine metabolism:Tyrosine metabolism:Selenocompound metabolism:Selenocompound metabolism:Pyruvate metabolism:Pyruvate metabolism:Polycyclic aromatic hydrocarbon degradation:Polycyclic aromatic hydrocarbon degradation:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Methane metabolism:Lipoic acid metabolism:Lipoic acid metabolism:Folate biosynthesis:Folate biosynthesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Phosphotransferase system (PTS):Phosphotransferase system (PTS):General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:smpB:smpB:sensory_box:sensory_box:GGDEF:GGDEF:hydA:hydA:rumA:rumA:lipA:lipA:PTS_I_fam:PTS_I_fam:cobM_cbiF:cobM_cbiF:queuosine_QueD:queuosine_QueD:Metabolism:Global:Electron transport:Small molecule interactions:Other:tRNA and rRNA base modification:Heme, porphyrin, and cobalamin:Lipoate:Other:Energy metabolism:Regulatory functions:Protein synthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Signal transduction:Metabolism:Membrane Transport:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Regulatory functions:Small molecule interactions:Protein synthesis:Other:tRNA and rRNA base modification:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Lipoate:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Other Amino Acids:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Environmental Information Processing" 292 "Energy production and conversion:Energy production and conversion:Phenylalanyl-tRNA synthetase alpha subunit:Phenylalanyl-tRNA synthetase alpha subunit:Pentose-5-phosphate-3-epimerase:Pentose-5-phosphate-3-epimerase:3,4-dihydroxy-2-butanone 4-phosphate synthase:3,4-dihydroxy-2-butanone 4-phosphate synthase:Isopropylmalate/homocitrate/citramalate synthases:Isopropylmalate/homocitrate/citramalate synthases:Ribosomal protein L24:Ribosomal protein L24:Translation initiation factor 3 (IF-3):Translation initiation factor 3 (IF-3):Threonyl-tRNA synthetase:Threonyl-tRNA synthetase:CTP synthase (UTP-ammonia lyase):CTP synthase (UTP-ammonia lyase):Thiol-disulfide isomerase and thioredoxins:Thiol-disulfide isomerase and thioredoxins:UDP-N-acetyl-D-mannosaminuronate dehydrogenase:UDP-N-acetyl-D-mannosaminuronate dehydrogenase:N6-adenine-specific methylase:N6-adenine-specific methylase:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:ABC-type Fe3+ transport system, permease component:ABC-type Fe3+ transport system, permease component:CMP-2-keto-3-deoxyoctulosonic acid synthetase:CMP-2-keto-3-deoxyoctulosonic acid synthetase:Low specificity phosphatase (HAD superfamily):Low specificity phosphatase (HAD superfamily):Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits:Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits:3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase:3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase:Predicted transcriptional regulator with C-terminal CBS domains:Predicted transcriptional regulator with C-terminal CBS domains:Acetyl/propionyl-CoA carboxylase, alpha subunit:Acetyl/propionyl-CoA carboxylase, alpha subunit:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:magnesium ion binding:nucleic acid binding:structural constituent of ribosome:translation initiation factor activity:catalytic activity:CTP synthase activity:GTPase activity:GTP cyclohydrolase II activity:biotin carboxylase activity:phosphogluconate dehydrogenase (decarboxylating) activity:pyruvate carboxylase activity:ribulose-phosphate 3-epimerase activity:phenylalanine-tRNA ligase activity:threonine-tRNA ligase activity:transporter activity:ATP binding:carbohydrate metabolic process:pentose-phosphate shunt:electron transport:pyrimidine nucleotide biosynthetic process:translation:translational initiation:phenylalanyl-tRNA aminoacylation:threonyl-tRNA aminoacylation:glycerol ether metabolic process:transport:metabolic process:methyltransferase activity:protein-synthesizing GTPase activity:3-deoxy-8-phosphooctulonate synthase activity:3,4-dihydroxy-2-butanone-4-phosphate synthase activity:3-deoxy-manno-octulosonate cytidylyltransferase activity:electron carrier activity:biosynthetic process:lipopolysaccharide biosynthetic process:riboflavin biosynthetic process:biotin binding:protein disulfide oxidoreductase activity:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:antioxidant activity:oxidoreductase activity:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor:ATPase activity:2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity:hydrogensulfite reductase activity:3-deoxy-manno-octulosonate-8-phosphatase activity:dissimilatory sulfate reduction:heme binding:methylation:cell redox homeostasis:glycerol-3-phosphate catabolic process:NAD binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pentose phosphate pathway:Pentose phosphate pathway:Pentose and glucuronate interconversions:Pentose and glucuronate interconversions:Pyrimidine metabolism:Pyrimidine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Nitrotoluene degradation:Nitrotoluene degradation:Riboflavin metabolism:Riboflavin metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Ribosome:Ribosome:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00095:TIGR00095:infC:infC:PyrG:PyrG:thrS:thrS:pheS:pheS:ribA:ribA:rplX_bact:rplX_bact:rpe:rpe:KDO8P_synth:KDO8P_synth:YrbI-phosphatas:YrbI-phosphatas:dsrA:dsrA:dsrB:dsrB:NDP-sugDHase:NDP-sugDHase:Information storage and processing:Pyrimidine ribonucleotide biosynthesis:Central intermediary metabolism:Sulfur metabolism:Energy metabolism:Pentose phosphate pathway:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Translation factors:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Nucleotide Metabolism:Xenobiotics Biodegradation and Metabolism:Translation:Membrane Transport:Carbohydrate Metabolism:Metabolism:Metabolism:Pentose phosphate pathway:Genetic Information Processing:Environmental Information Processing:Global:Sulfur metabolism:Cell envelope:Biosynthesis of cofactors, prosthetic groups, and carriers:Protein synthesis:Purines, pyrimidines, nucleosides, and nucleotides:Energy metabolism:Central intermediary metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Riboflavin, FMN, and FAD:Translation factors:tRNA and rRNA base modification:Ribosomal proteins: synthesis and modification:tRNA aminoacylation:Genetic Information Processing:Translation:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Metabolism of Cofactors and Vitamins:Global:Metabolism:Glycan Biosynthesis and Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling" 293 "Energy production and conversion:Energy production and conversion:Predicted membrane protein:Predicted membrane protein:Nitrogenase molybdenum-iron protein, alpha and beta chains:Nitrogenase molybdenum-iron protein, alpha and beta chains:Molybdenum cofactor biosynthesis enzyme:Molybdenum cofactor biosynthesis enzyme:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:two-component signal transduction system (phosphorelay):nucleotide binding:ciliary or flagellar motility:sequence-specific DNA binding transcription factor activity:motor activity:catalytic activity:ATP binding:electron transport:regulation of transcription, DNA-dependent:chemotaxis:transcription factor binding:metabolic process:nitrogen fixation:nitrogenase activity:transcription activator activity:iron-iron nitrogenase activity:molybdenum-iron nitrogenase activity:vanadium-iron nitrogenase activity:nucleoside-triphosphatase activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Nitrogen metabolism:Nitrogen metabolism:Two-component system:Two-component system:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:Environmental Information Processing:Signal Transduction:Energy Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Environmental Information Processing:Metabolism:Signal Transduction:Energy Metabolism" 294 "Energy production and conversion:Energy production and conversion:Thiol-disulfide isomerase and thioredoxins:Thiol-disulfide isomerase and thioredoxins:Hypoxanthine-guanine phosphoribosyltransferase:Hypoxanthine-guanine phosphoribosyltransferase:Ribose 5-phosphate isomerase RpiB:Ribose 5-phosphate isomerase RpiB:MoxR-like ATPases:MoxR-like ATPases:Bacterial cell division membrane protein:Bacterial cell division membrane protein:Biopolymer transport protein:Biopolymer transport protein:Predicted ATPases:Predicted ATPases:Methionine synthase I, cobalamin-binding domain:Methionine synthase I, cobalamin-binding domain:Na+/H+ antiporter:Na+/H+ antiporter:Iron only hydrogenase large subunit, C-terminal domain:Iron only hydrogenase large subunit, C-terminal domain:Flp pilus assembly protein TadD, contains TPR repeats:Flp pilus assembly protein TadD, contains TPR repeats:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:dihydropteroate synthase activity:hypoxanthine phosphoribosyltransferase activity:ribose-5-phosphate isomerase activity:transporter activity:binding:iron ion binding:ATP binding:pentose-phosphate shunt:electron transport:purine ribonucleoside salvage:RNA processing:glycerol ether metabolic process:transport:cell cycle:chromosome segregation:regulation of cell shape:methionine synthase activity:homocysteine S-methyltransferase activity:ferredoxin hydrogenase activity:electron carrier activity:methionine biosynthetic process:folic acid-containing compound biosynthetic process:protein disulfide oxidoreductase activity:amino acid transmembrane transporter activity:antioxidant activity:oxidoreductase activity:ATPase activity:chromosome condensation:cobalamin binding:cell redox homeostasis:metal ion binding:cobaltochelatase activity:iron-sulfur cluster binding:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Pentose phosphate pathway:Pentose phosphate pathway:Purine metabolism:Purine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:One carbon pool by folate:One carbon pool by folate:Methane metabolism:Methane metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:rpiB_lacA_lacB:rpiB_lacA_lacB:HGPRTase:HGPRTase:TAT_signal_seq:TAT_signal_seq:MJ0042_CXXC:MJ0042_CXXC:rodA_shape:rodA_shape:FeFe_hydrog_A:FeFe_hydrog_A:tolR:tolR:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Protein fate:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Cell division:Pathogenesis:Cellular processes and signaling:Metabolism:Poorly characterized:Purines, pyrimidines, nucleosides, and nucleotides:Pathogenesis:Cell division:Protein and peptide secretion and trafficking:Salvage of nucleosides and nucleotides:Global:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Energy Metabolism:Energy Metabolism:Amino Acid Metabolism:Carbohydrate Metabolism:Metabolism of Cofactors and Vitamins:Metabolism:Poorly characterized:Global:Metabolism:Metabolism:Cellular processes and signaling:Cellular processes" 295 "Energy production and conversion:Energy production and conversion:Shikimate 5-dehydrogenase:Shikimate 5-dehydrogenase:NADPH:quinone reductase and related Zn-dependent oxidoreductases:NADPH:quinone reductase and related Zn-dependent oxidoreductases:Cation/multidrug efflux pump:Cation/multidrug efflux pump:Sugar phosphate isomerases/epimerases:Sugar phosphate isomerases/epimerases:UTP:GlnB (protein PII) uridylyltransferase:UTP:GlnB (protein PII) uridylyltransferase:Soluble P-type ATPase:Soluble P-type ATPase:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):DNA binding:single-stranded DNA binding:NADPH:quinone reductase activity:endonuclease activity:shikimate 3-dehydrogenase (NADP+) activity:transporter activity:DNA repair:regulation of transcription, DNA-dependent:nitrogen compound metabolic process:transport:metabolic process:zinc ion binding:[protein-PII] uridylyltransferase activity:cyclic nucleotide biosynthetic process:amino acid binding:phosphorus-oxygen lyase activity:quinate/shikimate dehydrogenase activity:intracellular signal transduction:NADP binding:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:aroE:aroE:2A0602:2A0602:UTase_glnD:UTase_glnD:Defense mechanisms:Defense mechanisms:Global:Metabolism:Regulatory functions:Aromatic amino acid family:Regulatory functions:Protein interactions:Small molecule interactions:Transport and binding proteins:Unknown substrate:Amino acid biosynthesis:Aromatic amino acid family:Cellular processes and signaling:Metabolism:Poorly characterized:Unknown substrate:Small molecule interactions:Protein interactions:Global:Environmental Information Processing:Metabolism:Metabolism:Amino Acid Metabolism:Signal Transduction:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Amino Acid Metabolism:Amino acid biosynthesis:Environmental Information Processing:Signal Transduction:Transport and binding proteins" 296 "Xaa-Pro aminopeptidase:Xaa-Pro aminopeptidase:3-phosphoglycerate kinase:3-phosphoglycerate kinase:N-methylhydantoinase A/acetone carboxylase, beta subunit:N-methylhydantoinase A/acetone carboxylase, beta subunit:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases:Cation transport ATPase:Cation transport ATPase:Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:Exonuclease III:Exonuclease III:Phosphopantetheinyl transferase (holo-ACP synthase):Phosphopantetheinyl transferase (holo-ACP synthase):FOG: CheY-like receiver:FOG: CheY-like receiver:Mannose-1-phosphate guanylyltransferase:Mannose-1-phosphate guanylyltransferase:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:ADP-ribose pyrophosphatase:ADP-ribose pyrophosphatase:Flagellar motor component:Flagellar motor component:Predicted periplasmic or secreted lipoprotein:Predicted periplasmic or secreted lipoprotein:Predicted periplasmic ligand-binding sensor domain:Predicted periplasmic ligand-binding sensor domain:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:magnesium ion binding:ciliary or flagellar motility:nucleic acid binding:DNA binding:peptidyl-prolyl cis-trans isomerase activity:motor activity:acetate-CoA ligase activity:X-Pro dipeptidase activity:serine-type endopeptidase activity:endonuclease activity:cyclophilin:phosphoglycerate kinase activity:signal transducer activity:binding:ATP binding:glycolysis:electron transport:DNA repair:regulation of transcription, DNA-dependent:proteolysis:creatine metabolic process:fatty acid biosynthetic process:transport:amino acid transport:chemotaxis:response to stress:signal transduction:metabolic process:metalloexopeptidase activity:protein transporter activity:exodeoxyribonuclease III activity:holo-[acyl-carrier-protein] synthase activity:mannose-1-phosphate guanylyltransferase (GDP) activity:nitrate reductase activity:macromolecule biosynthetic process:lipopolysaccharide biosynthetic process:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism:proton transport:AMP binding:hydrolase activity:creatinase activity:FK506-sensitive peptidyl-prolyl cis-trans isomerase:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:Lipid transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Fructose and mannose metabolism:Fructose and mannose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Pyruvate metabolism:Propanoate metabolism:Propanoate metabolism:Methane metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Base excision repair:Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:exoDNase_III:exoDNase_III:sensory_box:sensory_box:acpS:acpS:GMP_PMI:GMP_PMI:ATPase_P-type:ATPase_P-type:Ac_CoA_lig_AcsA:Ac_CoA_lig_AcsA:Environmental Information Processing:Global:Biosynthesis:Small molecule interactions:DNA replication, recombination, and repair:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Fatty acid and phospholipid metabolism:Regulatory functions:DNA metabolism:Cell envelope:Genetic Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Replication and Repair:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins:Energy Metabolism:Carbohydrate Metabolism:Cellular Processes" 297 "GTPases - translation elongation factors:GTPases - translation elongation factors:Ribosomal protein L1:Ribosomal protein L1:Ribosomal protein L27:Ribosomal protein L27:Ribosomal protein S16:Ribosomal protein S16:Ribosomal protein L31:Ribosomal protein L31:Ribosomal protein L21:Ribosomal protein L21:Ribosomal protein S20:Ribosomal protein S20:Ribosomal protein L19:Ribosomal protein L19:FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor):FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor):Bacterial nucleoid DNA-binding protein:Bacterial nucleoid DNA-binding protein:Preprotein translocase subunit SecG:Preprotein translocase subunit SecG:DnaK suppressor protein:DnaK suppressor protein:Preprotein translocase subunit YajC:Preprotein translocase subunit YajC:Outer membrane protein:Outer membrane protein:DNA binding:RNA binding:structural constituent of ribosome:translation elongation factor activity:peptidyl-prolyl cis-trans isomerase activity:GTPase activity:cyclophilin:protein binding:GTP binding:translation:translational elongation:protein folding:zinc ion binding:protein-synthesizing GTPase activity:CDP-diacylglycerol diphosphatase activity:agmatinase activity:protein secretion:protein transport:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:FK506-sensitive peptidyl-prolyl cis-trans isomerase:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Ribosome:Ribosome:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Signal transduction mechanisms:Signal transduction mechanisms:S16:S16:S20:S20:S21p:S21p:L21:L21:L27:L27:L31:L31:tig:tig:small_GTP:small_GTP:yajC:yajC:secG:secG:rplS_bact:rplS_bact:rplA_bact:rplA_bact:dksA:dksA:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Regulatory functions:Regulatory functions:Small molecule interactions:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein folding and stabilization:Protein and peptide secretion and trafficking:Unknown function:General:Information storage and processing:Cellular processes and signaling:Genetic Information Processing:Membrane Transport:Folding Sorting and Degradation:Folding Sorting and Degradation:Translation:Protein synthesis:Small molecule interactions:Translation:Genetic Information Processing:Cellular processes and signaling:Information storage and processing:Ribosomal proteins: synthesis and modification:Protein folding and stabilization:Protein and peptide secretion and trafficking:General:Unknown function:Protein fate:Environmental Information Processing:Membrane Transport:Environmental Information Processing" 298 "Acetolactate synthase, small (regulatory) subunit:Acetolactate synthase, small (regulatory) subunit:Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:ABC-type molybdate transport system, periplasmic component:ABC-type molybdate transport system, periplasmic component:Flagellar basal body-associated protein:Flagellar basal body-associated protein:Exonuclease VII small subunit:Exonuclease VII small subunit:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):ciliary or flagellar motility:sequence-specific DNA binding transcription factor activity:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity:acetolactate synthase activity:biotin-[acetyl-CoA-carboxylase] ligase activity:transporter activity:DNA catabolic process:regulation of transcription, DNA-dependent:protein modification process:transport:chemotaxis:response to stress:exodeoxyribonuclease VII activity:protein-glutamate methylesterase activity:branched chain family amino acid biosynthetic process:valine biosynthetic process:molybdate transmembrane-transporting ATPase activity:molybdate ion transport:amino acid binding:sequence-specific DNA binding:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Biotin metabolism:Biotin metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Mismatch repair:Mismatch repair:Signal transduction mechanisms:Signal transduction mechanisms:acolac_sm:acolac_sm:modA:modA:Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Replication and Repair:Membrane Transport:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:Anions:Pyruvate family:Transport and binding proteins:Amino acid biosynthesis:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transport and binding proteins:Anions:Amino acid biosynthesis:Pyruvate family:Information storage and processing:Cellular processes and signaling" 299 "Uncharacterized NAD(FAD)-dependent dehydrogenases:Uncharacterized NAD(FAD)-dependent dehydrogenases:FOG: CheY-like receiver:FOG: CheY-like receiver:DNA polymerase III, epsilon subunit and related 3'-5' exonucleases:DNA polymerase III, epsilon subunit and related 3'-5' exonucleases:Predicted ATPase related to phosphate starvation-inducible protein PhoH:Predicted ATPase related to phosphate starvation-inducible protein PhoH:Predicted transcriptional regulator:Predicted transcriptional regulator:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted signal-transduction protein containing cAMP-binding and CBS domains:Predicted signal-transduction protein containing cAMP-binding and CBS domains:Phage terminase-like protein, large subunit:Phage terminase-like protein, large subunit:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Bacteriophage capsid protein:Bacteriophage capsid protein:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:catalytic activity:DNA-directed DNA polymerase activity:exonuclease activity:ATP binding:regulation of transcription, DNA-dependent:metabolic process:cyclic nucleotide biosynthetic process:cellular response to phosphate starvation:phosphorus-oxygen lyase activity:intracellular signal transduction:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Metabolic pathways:Metabolic pathways:DNA replication:DNA replication:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:rrf2_super:rrf2_super:portal_lambda:portal_lambda:Global:Metabolism:Genetic Information Processing:Global:Small molecule interactions:Regulatory functions:Regulatory functions:Small molecule interactions:Mobile and extrachromosomal element functions:Prophage functions:Unknown function:General:Information storage and processing:Cellular processes and signaling:Poorly characterized:Genetic Information Processing:Metabolism:Nucleotide Metabolism:Metabolism:Poorly characterized:Metabolism:Replication and Repair:Nucleotide Metabolism:Mobile and extrachromosomal element functions:Cellular processes and signaling:Information storage and processing:Prophage functions:General:Unknown function:Replication and Repair" 300 "Glycosyltransferase:Glycosyltransferase:Metal-dependent proteases with possible chaperone activity:Metal-dependent proteases with possible chaperone activity:Uncharacterized conserved protein:Uncharacterized conserved protein:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:ABC-type transport system involved in resistance to organic solvents, permease component:ABC-type transport system involved in resistance to organic solvents, permease component:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:N-acetylmuramoyl-L-alanine amidase:N-acetylmuramoyl-L-alanine amidase:Cytochrome c biogenesis factor:Cytochrome c biogenesis factor:Cell shape-determining protein:Cell shape-determining protein:Predicted N-acetylglucosaminyl transferase:Predicted N-acetylglucosaminyl transferase:ABC-type sugar transport systems, ATPase components:ABC-type sugar transport systems, ATPase components:ABC-type transport system, involved in lipoprotein release, permease component:ABC-type transport system, involved in lipoprotein release, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:ribonuclease P activity:transporter activity:binding:ATP binding:regulation of transcription, DNA-dependent:proteolysis:transport:zinc ion binding:regulation of cell shape:O-sialoglycoprotein endopeptidase activity:respiratory chain complex IV assembly:N-acetylmuramoyl-L-alanine amidase activity:biosynthetic process:peptidoglycan catabolic process:heme transporter activity:glycerol-3-phosphate-transporting ATPase activity:heme transport:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances:ATPase activity:cytochrome complex assembly:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:ABC transporters:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:Function unknown:TIGR00056:TIGR00056:mreC:mreC:TIGR00278:TIGR00278:gcp_kae1:gcp_kae1:HEQRo_perm_3TM:HEQRo_perm_3TM:lolCE:lolCE:Metabolism:Poorly characterized:Hypothetical proteins:Transport and binding proteins:Protein fate:Biosynthesis and degradation of murein sacculus and peptidoglycan:Conserved:Amino acids, peptides and amines:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking:Environmental Information Processing:Membrane Transport:Cell envelope:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Membrane Transport:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Amino acids, peptides and amines:Hypothetical proteins:Conserved:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cellular processes and signaling" 301 "Energy production and conversion:Energy production and conversion:Cell division GTPase:Cell division GTPase:Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis:Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis:Aspartate/tyrosine/aromatic aminotransferase:Aspartate/tyrosine/aromatic aminotransferase:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:UDP-N-acetylmuramyl tripeptide synthase:UDP-N-acetylmuramyl tripeptide synthase:UDP-N-acetylmuramyl pentapeptide synthase:UDP-N-acetylmuramyl pentapeptide synthase:UDP-N-acetylmuramoylalanine-D-glutamate ligase:UDP-N-acetylmuramoylalanine-D-glutamate ligase:Bacterial cell division membrane protein:Bacterial cell division membrane protein:UDP-N-acetylmuramate-alanine ligase:UDP-N-acetylmuramate-alanine ligase:Actin-like ATPase involved in cell division:Actin-like ATPase involved in cell division:Cell division septal protein:Cell division septal protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Ni,Fe-hydrogenase III small subunit:Ni,Fe-hydrogenase III small subunit:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:cell morphogenesis:catalytic activity:GTPase activity:ATP binding:GTP binding:mitochondrial electron transport, NADH to ubiquinone:cell cycle:NADH dehydrogenase (ubiquinone) activity:methyltransferase activity:regulation of cell shape:D-alanine-D-alanine ligase activity:UDP-N-acetylmuramate-L-alanine ligase activity:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity:phospho-N-acetylmuramoyl-pentapeptide-transferase activity:biosynthetic process:purine ribonucleoside monophosphate biosynthetic process:peptidoglycan biosynthetic process:transferase activity, transferring nitrogenous groups:deaminase activity:UDP-N-acetylgalactosamine biosynthetic process:pyridoxal phosphate binding:carbohydrate binding:lipid glycosylation:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity:protein polymerization:cell division:4 iron, 4 sulfur cluster binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Lysine biosynthesis:Lysine biosynthesis:D-Glutamine and D-glutamate metabolism:D-Glutamine and D-glutamate metabolism:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Metabolic pathways:Metabolic pathways:Function unknown:Function unknown:TIGR00006:TIGR00006:ftsZ:ftsZ:TIGR00242:TIGR00242:mraY:mraY:murC:murC:murE:murE:murD:murD:murG:murG:murF:murF:ftsA:ftsA:ftsW:ftsW:Cell division:Unknown function:General:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Cell envelope:Unknown function:Cellular processes:Biosynthesis and degradation of murein sacculus and peptidoglycan:General:Cell division:Global:Metabolism:Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Global:Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Amino Acid Metabolism:Amino Acid Metabolism:Cellular processes" 302 "" 303 "Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Molecular chaperone (small heat shock protein):Molecular chaperone (small heat shock protein):Nucleoside-diphosphate-sugar epimerases:Nucleoside-diphosphate-sugar epimerases:Branched-chain amino acid ABC-type transport system, permease components:Branched-chain amino acid ABC-type transport system, permease components:ABC-type transport system involved in cytochrome c biogenesis, permease component:ABC-type transport system involved in cytochrome c biogenesis, permease component:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:Flagellar motor component:Flagellar motor component:Transcriptional regulators:Transcriptional regulators:FOG: GGDEF domain:FOG: GGDEF domain:Cation transport ATPase:Cation transport ATPase:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted N-acetylglucosaminyl transferase:Predicted N-acetylglucosaminyl transferase:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:succinate dehydrogenase activity:magnesium ion binding:ciliary or flagellar motility:sequence-specific DNA binding transcription factor activity:motor activity:acetolactate synthase activity:copper-exporting ATPase activity:transporter activity:binding:ATP binding:carbohydrate metabolic process:regulation of transcription, DNA-dependent:transport:chemotaxis:metabolic process:respiratory chain complex IV assembly:branched chain family amino acid biosynthetic process:valine biosynthetic process:cyclic nucleotide biosynthetic process:proton transport:transferase activity:hydrolase activity:phosphorus-oxygen lyase activity:racemase and epimerase activity, acting on carbohydrates and derivatives:metal ion transport:thiamine pyrophosphate binding:intracellular signal transduction:cellular metabolic process:flavin adenine dinucleotide binding:coenzyme binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Oxidative phosphorylation:Oxidative phosphorylation:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:acolac_lg:acolac_lg:GGDEF:GGDEF:ATPase-IB_hvy:ATPase-IB_hvy:MotA1:MotA1:Carbohydrate Metabolism:Global:Metabolism:Metabolism:Poorly characterized:Metabolism:Amino acid biosynthesis:Pyruvate family:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Membrane Transport:Signal Transduction:Signal transduction:Amino acid biosynthesis:Other:Pyruvate family:Global:Cellular Processes:Environmental Information Processing:Metabolism:Environmental Information Processing:Cell Motility:Membrane Transport:Metabolism of Cofactors and Vitamins:Signal Transduction:Amino Acid Metabolism:Cellular Processes:Cell Motility:Energy Metabolism" 304 "Energy production and conversion:Energy production and conversion:Guanylate kinase:Guanylate kinase:ABC-type phosphate transport system, periplasmic component:ABC-type phosphate transport system, periplasmic component:Orotidine-5'-phosphate decarboxylase:Orotidine-5'-phosphate decarboxylase:Ribonuclease HI:Ribonuclease HI:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Glycosyltransferase:Glycosyltransferase:K+ transport systems, NAD-binding component:K+ transport systems, NAD-binding component:ABC-type phosphate transport system, permease component:ABC-type phosphate transport system, permease component:2-methylthioadenine synthetase:2-methylthioadenine synthetase:Penicillin tolerance protein:Penicillin tolerance protein:6Fe-6S prismane cluster-containing protein:6Fe-6S prismane cluster-containing protein:DNA-directed RNA polymerase specialized sigma subunit:DNA-directed RNA polymerase specialized sigma subunit:Oxygen-sensitive ribonucleoside-triphosphate reductase:Oxygen-sensitive ribonucleoside-triphosphate reductase:Uncharacterized stress-induced protein:Uncharacterized stress-induced protein:Adenosine deaminase:Adenosine deaminase:FOG: GGDEF domain:FOG: GGDEF domain:Aldehyde:ferredoxin oxidoreductase:Aldehyde:ferredoxin oxidoreductase:Predicted methyltransferase:Predicted methyltransferase:Response regulator of the LytR/AlgR family:Response regulator of the LytR/AlgR family:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Nucleotide transport and metabolism:rRNA modification:two-component response regulator activity:two-component signal transduction system (phosphorelay):rRNA (adenine-N6,N6-)-dimethyltransferase activity:nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:catalytic activity:DNA-directed RNA polymerase activity:membrane-associated guanylate kinase:guanylate kinase activity:ribonuclease H activity:orotidine-5'-phosphate decarboxylase activity:phosphatidylserine decarboxylase activity:phosphogluconate dehydrogenase (decarboxylating) activity:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity:transporter activity:inorganic phosphate transmembrane transporter activity:electron transporter activity:pentose-phosphate shunt:electron transport:'de novo' pyrimidine base biosynthetic process:transcription initiation, DNA-dependent:regulation of transcription, DNA-dependent:RNA catabolic process:protein modification process:protein dephosphorylation:proteolysis:transport:potassium ion transport:phosphate ion transport:protein tyrosine/serine/threonine phosphatase activity:metabolic process:metallopeptidase activity:protein methyltransferase activity:cation transmembrane transporter activity:ribonucleoside-triphosphate reductase activity:biosynthetic process:cyclic nucleotide biosynthetic process:cobalamin biosynthetic process:oxidoreductase activity, acting on other nitrogenous compounds as donors:phosphorus-oxygen lyase activity:sigma factor activity:isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway:pyridoxal phosphate binding:2-alkenal reductase [NAD(P)] activity:aldehyde ferredoxin oxidoreductase activity:intracellular signal transduction:sequence-specific DNA binding:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity:iron-sulfur cluster binding:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose phosphate pathway:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Pyruvate metabolism:Pyruvate metabolism:Methane metabolism:Methane metabolism:Thiamine metabolism:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:RNA polymerase:RNA polymerase:DNA replication:DNA replication:Sulfur relay system:Sulfur relay system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00089:TIGR00089:ispH_lytB:ispH_lytB:GGDEF:GGDEF:TIGR00255:TIGR00255:3a0107s02c:3a0107s02c:hybrid_clust:hybrid_clust:pyrF:pyrF:ptsS_2:ptsS_2:thiF_fam2:thiF_fam2:CbiE:CbiE:FliA_WhiG:FliA_WhiG:NrdD:NrdD:guanyl_kin:guanyl_kin:Global:Metabolism:Replication and Repair:Folding Sorting and Degradation:Transcription:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Energy metabolism:Amino acids and amines:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Pyrimidine ribonucleotide biosynthesis:2'-Deoxyribonucleotide metabolism:Transport and binding proteins:Anions:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Thiamine:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Signal transduction:Biosynthesis of cofactors, prosthetic groups, and carriers:Hypothetical proteins:Transport and binding proteins:Purines, pyrimidines, nucleosides, and nucleotides:Energy metabolism:Other:Thiamine:Other:Conserved:Anions:2'-Deoxyribonucleotide metabolism:Pyrimidine ribonucleotide biosynthesis:Nucleotide and nucleoside interconversions:Amino acids and amines:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Signal Transduction:Membrane Transport:Replication and Repair:Folding Sorting and Degradation:Transcription:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism:Signal Transduction:Membrane Transport:Environmental Information Processing" 305 "Energy production and conversion:Energy production and conversion:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Anaerobic dehydrogenases, typically selenocysteine-containing:Anaerobic dehydrogenases, typically selenocysteine-containing:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Thioredoxin reductase:Thioredoxin reductase:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:Uncharacterized membrane protein, putative virulence factor:Uncharacterized membrane protein, putative virulence factor:Acyl-CoA synthetase (NDP forming):Acyl-CoA synthetase (NDP forming):Primosomal protein N' (replication factor Y) - superfamily II helicase:Primosomal protein N' (replication factor Y) - superfamily II helicase:Purine-cytosine permease and related proteins:Purine-cytosine permease and related proteins:Uncharacterized protein involved in formate dehydrogenase formation:Uncharacterized protein involved in formate dehydrogenase formation:Arylsulfatase A and related enzymes:Arylsulfatase A and related enzymes:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Nucleotide transport and metabolism:two-component sensor activity:DNA binding:protein histidine kinase activity:thioredoxin-disulfide reductase activity:signal transducer activity:iron ion binding:ATP binding:electron transport:DNA replication:DNA methylation:regulation of transcription, DNA-dependent:signal transduction:ATP-dependent helicase activity:metabolic process:N-methyltransferase activity:sulfuric ester hydrolase activity:formate dehydrogenase (NAD+) activity:electron carrier activity:pathogenesis:peptidyl-histidine phosphorylation:heme binding:molybdenum ion binding:thiamine pyrophosphate binding:indolepyruvate ferredoxin oxidoreductase activity:cellular respiration:iron-sulfur cluster binding:Replication, recombination and repair:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Peptidoglycan biosynthesis:Peptidoglycan biosynthesis:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:priA:priA:formate-DH-alph:formate-DH-alph:Energy Metabolism:Global:Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Energy metabolism:Electron transport:DNA metabolism:DNA replication, recombination, and repair:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Carbohydrate Metabolism:Information storage and processing:DNA metabolism:Energy metabolism:DNA replication, recombination, and repair:Electron transport:Global:Genetic Information Processing:Metabolism:Metabolism:Replication and Repair:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Genetic Information Processing:Replication and Repair" 306 "Energy production and conversion:Energy production and conversion:Phenylalanyl-tRNA synthetase beta subunit:Phenylalanyl-tRNA synthetase beta subunit:Glutamate decarboxylase and related PLP-dependent proteins:Glutamate decarboxylase and related PLP-dependent proteins:Ribosomal protein L7/L12:Ribosomal protein L7/L12:Fe-S oxidoreductase:Fe-S oxidoreductase:Site-specific DNA methylase:Site-specific DNA methylase:(acyl-carrier-protein) S-malonyltransferase:(acyl-carrier-protein) S-malonyltransferase:tRNA-(guanine-N1)-methyltransferase:tRNA-(guanine-N1)-methyltransferase:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Ribosomal protein S6:Ribosomal protein S6:Thiamine biosynthesis protein ThiC:Thiamine biosynthesis protein ThiC:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Uncharacterized ABC-type transport system, permease component:Uncharacterized ABC-type transport system, permease component:ABC-type Mn/Zn transport systems, ATPase component:ABC-type Mn/Zn transport systems, ATPase component:Predicted membrane protein:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Coenzyme F390 synthetase:Coenzyme F390 synthetase:L-lactate permease:L-lactate permease:Permeases:Permeases:Tfp pilus assembly protein, pilus retraction ATPase PilT:Tfp pilus assembly protein, pilus retraction ATPase PilT:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:ABC-type phosphate/phosphonate transport system, ATPase component:ABC-type phosphate/phosphonate transport system, ATPase component:Amino acid transport and metabolism:Amino acid transport and metabolism:tRNA binding:magnesium ion binding:DNA binding:RNA binding:structural constituent of ribosome:DNA-directed RNA polymerase activity:DNA-directed RNA polymerase I activity:DNA-directed RNA polymerase II activity:DNA-directed RNA polymerase III activity:[acyl-carrier-protein] S-malonyltransferase activity:hypoxanthine phosphoribosyltransferase activity:phenylalanine-tRNA ligase activity:ionotropic glutamate receptor activity:transporter activity:extracellular-glutamate-gated ion channel activity:ATP binding:carbohydrate metabolic process:electron transport:DNA methylation:transcription, DNA-dependent:tRNA modification:translation:phenylalanyl-tRNA aminoacylation:cellular amino acid metabolic process:fatty acid biosynthetic process:transport:tRNA processing:metabolic process:hydroxymethylpyrimidine kinase activity:phosphomethylpyrimidine kinase activity:tRNA (guanine-N1-)-methyltransferase activity:electron carrier activity:thiamine biosynthetic process:lactate transmembrane transporter activity:phosphonate transmembrane-transporting ATPase activity:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:iron-chelate-transporting ATPase activity:phosphonate transport:lactate transport:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:carboxy-lyase activity:ATPase activity:nucleoside-triphosphatase activity:carboxylic acid metabolic process:heme binding:pyridoxal phosphate binding:phenylacetate-CoA ligase activity:iron-sulfur cluster binding:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Fatty acid biosynthesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Histidine metabolism:Histidine metabolism:Tyrosine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Tryptophan metabolism:Tryptophan metabolism:Thiamine metabolism:Thiamine metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Ribosome:Ribosome:RNA polymerase:RNA polymerase:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:trmD:trmD:HMP-P_kinase:HMP-P_kinase:fabD:fabD:S6:S6:thiC:thiC:pheT_bact:pheT_bact:dcm:dcm:lctP:lctP:L12:L12:pilT_fam:pilT_fam:HEQRo_perm_3TM:HEQRo_perm_3TM:rpoB:rpoB:ABC_phnC:ABC_phnC:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Lipid Metabolism:Metabolism:Protein synthesis:Environmental Information Processing:Global:Biosynthesis:DNA replication, recombination, and repair:DNA-dependent RNA polymerase:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Amino acids, peptides and amines:Anions:Carbohydrates, organic alcohols, and acids:Chemotaxis and motility:Thiamine:Fatty acid and phospholipid metabolism:DNA metabolism:Transcription:Protein synthesis:Transport and binding proteins:Cellular processes:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Membrane Transport:Translation:Transcription:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Transcription:DNA-dependent RNA polymerase:Genetic Information Processing:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Transport and binding proteins:Amino acids, peptides and amines:Anions:Carbohydrates, organic alcohols, and acids:Cellular processes:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Nucleotide Metabolism" 307 "Energy production and conversion:Energy production and conversion:Superfamily II DNA/RNA helicases, SNF2 family:Superfamily II DNA/RNA helicases, SNF2 family:Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain:Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain:Dissimilatory sulfite reductase (desulfoviridin), gamma subunit:Dissimilatory sulfite reductase (desulfoviridin), gamma subunit:DNA binding:fumarate hydratase activity:helicase activity:electron transporter activity:ATP binding:electron transport:proteolysis:metallopeptidase activity:zinc ion binding:hydrogensulfite reductase activity:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Sulfur relay system:Sulfur relay system:ttdA_fumA_fumB:ttdA_fumA_fumB:dsrC_tusE_dsvC:dsrC_tusE_dsvC:Information storage and processing:Metabolism:Carbohydrate Metabolism:Genetic Information Processing:Global:Metabolism:Metabolism:Folding Sorting and Degradation:Information storage and processing:Metabolism:Metabolism:Carbohydrate Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Global:Metabolism" 308 "Energy production and conversion:Energy production and conversion:Protein chain release factor A:Protein chain release factor A:Ribosomal protein L28:Ribosomal protein L28:Riboflavin synthase alpha chain:Riboflavin synthase alpha chain:Ribosomal protein L32:Ribosomal protein L32:Translation initiation factor 1 (IF-1):Translation initiation factor 1 (IF-1):Pseudouridylate synthases, 23S RNA-specific:Pseudouridylate synthases, 23S RNA-specific:Ni,Fe-hydrogenase maturation factor:Ni,Fe-hydrogenase maturation factor:Predicted xylanase/chitin deacetylase:Predicted xylanase/chitin deacetylase:Protease subunit of ATP-dependent Clp proteases:Protease subunit of ATP-dependent Clp proteases:GDP-D-mannose dehydratase:GDP-D-mannose dehydratase:MinD superfamily P-loop ATPase containing an inserted ferredoxin domain:MinD superfamily P-loop ATPase containing an inserted ferredoxin domain:Phosphatidylserine synthase:Phosphatidylserine synthase:Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family:Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family:Antitoxin of toxin-antitoxin stability system:Antitoxin of toxin-antitoxin stability system:3-methyladenine DNA glycosylase:3-methyladenine DNA glycosylase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):pseudouridine synthesis:DNA binding:RNA binding:structural constituent of ribosome:translation initiation factor activity:CDP-diacylglycerol-serine O-phosphatidyltransferase activity:GTPase activity:aminoacyl-tRNA hydrolase activity:pseudouridylate synthase activity:riboflavin synthase activity:ATP binding:carbohydrate metabolic process:electron transport:base-excision repair:DNA recombination:regulation of transcription, DNA-dependent:translation:translational initiation:translational termination:proteolysis:phosphatidylcholine biosynthetic process:enzyme activator activity:metabolic process:peptidase activity:GDP-mannose 4,6-dehydratase activity:endopeptidase Clp activity:protein-synthesizing GTPase activity:phospholipid biosynthetic process:DNA-3-methyladenine glycosylase I activity:dTDP-4-dehydrorhamnose reductase activity:electron carrier activity:cobalamin biosynthetic process:RNA modification:pseudouridine synthase activity:DNA integration:translation release factor activity, codon specific:protein processing:oxidoreductase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:peptidyl-histidine phosphorylation:GDP-mannose metabolic process:cobyrinic acid a,c-diamide synthase activity:extracellular polysaccharide biosynthetic process:metal ion binding:coenzyme binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Fructose and mannose metabolism:Fructose and mannose metabolism:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Riboflavin metabolism:Riboflavin metabolism:Metabolic pathways:Metabolic pathways:Ribosome:Ribosome:DNA replication:DNA replication:Base excision repair:Base excision repair:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:infA:infA:L28:L28:prfB:prfB:hydrog_prot:hydrog_prot:ribE:ribE:sensory_box:sensory_box:pssA:pssA:clpP:clpP:rpmF_bact:rpmF_bact:gmd:gmd:phd_fam:phd_fam:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis:Global:Genetic Information Processing:Metabolism:Metabolism:Replication and Repair:Carbohydrate Metabolism:Translation:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Mobile and extrachromosomal element functions:Protein fate:Protein synthesis:Regulatory functions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Lipid Metabolism:Riboflavin, FMN, and FAD:Nucleotide Metabolism:Other:Degradation of proteins, peptides, and glycopeptides:Amino Acid Metabolism:Translation factors:Metabolism of Cofactors and Vitamins:Ribosomal proteins: synthesis and modification:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Small molecule interactions:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:Protein synthesis:Ribosomal proteins: synthesis and modification:Translation factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Mobile and extrachromosomal element functions" 309 "Energy production and conversion:Energy production and conversion:Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain:Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:ABC-type cobalt transport system, permease component CbiQ and related transporters:ABC-type cobalt transport system, permease component CbiQ and related transporters:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Cation/multidrug efflux pump:Cation/multidrug efflux pump:Phosphatidylglycerophosphatase A and related proteins:Phosphatidylglycerophosphatase A and related proteins:Ni,Fe-hydrogenase I cytochrome b subunit:Ni,Fe-hydrogenase I cytochrome b subunit:HD-GYP domain:HD-GYP domain:Phosphotransferase system, mannose/fructose-specific component IIA:Phosphotransferase system, mannose/fructose-specific component IIA:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:catalytic activity:formate-tetrahydrofolate ligase activity:glycine cleavage system:glycine dehydrogenase (decarboxylating) activity:transporter activity:electron transport:regulation of transcription, DNA-dependent:glycine metabolic process:lipid metabolic process:transport:cobalt ion transport:phosphatidylglycerophosphatase activity:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity:cyclic nucleotide biosynthetic process:cobalamin biosynthetic process:phosphoenolpyruvate-dependent sugar phosphotransferase system:cobalt ion transmembrane transporter activity:oxidoreductase activity:phosphorus-oxygen lyase activity:pyridoxal phosphate binding:intracellular signal transduction:Lipid transport and metabolism:Lipid transport and metabolism:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Fructose and mannose metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:Phosphotransferase system (PTS):Phosphotransferase system (PTS):General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:HEQRo_perm_3TM:HEQRo_perm_3TM:CbiQ_TIGR:CbiQ_TIGR:Defense mechanisms:Defense mechanisms:Global:Membrane Transport:Environmental Information Processing:Cations and iron carrying compounds:Regulatory functions:Small molecule interactions:Transport and binding proteins:Amino acids, peptides and amines:Cations and iron carrying compounds:Cellular processes and signaling:Metabolism:Poorly characterized:Transport and binding proteins:Amino Acid Metabolism:Amino acids, peptides and amines:Small molecule interactions:Global:Environmental Information Processing:Metabolism:Metabolism:Lipid Metabolism:Membrane Transport:Amino Acid Metabolism:Carbohydrate Metabolism:Regulatory functions:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Lipid Metabolism:Cellular processes and signaling:Metabolism" 310 "Periplasmic serine proteases (ClpP class):Periplasmic serine proteases (ClpP class):proteolysis:peptidase activity:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Cellular processes and signaling" 311 "Energy production and conversion:Energy production and conversion:Diaminopimelate decarboxylase:Diaminopimelate decarboxylase:Glutamate synthase domain 2:Glutamate synthase domain 2:Dethiobiotin synthetase:Dethiobiotin synthetase:3-oxoacyl-(acyl-carrier-protein) synthase:3-oxoacyl-(acyl-carrier-protein) synthase:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Putative GTPases (G3E family):Putative GTPases (G3E family):Signal transduction histidine kinase:Signal transduction histidine kinase:Chemotaxis protein histidine kinase and related kinases:Chemotaxis protein histidine kinase and related kinases:Biopolymer transport proteins:Biopolymer transport proteins:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Biopolymer transport protein:Biopolymer transport protein:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:L-lactate permease:L-lactate permease:Uncharacterized protein conserved in archaea:Uncharacterized protein conserved in archaea:Transcriptional regulators:Transcriptional regulators:Uncharacterized protein involved in methicillin resistance:Uncharacterized protein involved in methicillin resistance:Amino acid transport and metabolism:Amino acid transport and metabolism:fatty-acyl-CoA binding:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:motor activity:catalytic activity:amidophosphoribosyltransferase activity:L-aspartate:2-oxoglutarate aminotransferase activity:dethiobiotin synthase activity:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity:glutamate synthase (NADPH) activity:protein histidine kinase activity:signal transducer activity:transporter activity:ATP binding:electron transport:regulation of transcription, DNA-dependent:glutamate biosynthetic process:transport:chemotaxis:signal transduction:metabolic process:protein transporter activity:diaminopimelate decarboxylase activity:electron carrier activity:biosynthetic process:lysine biosynthetic process via diaminopimelate:biotin biosynthetic process:purine base biosynthetic process:peptidoglycan biosynthetic process:flagellum assembly:lactate transmembrane transporter activity:lactate transport:glutamate synthase (NADH) activity:peptidyl-histidine phosphorylation:regulation of fatty acid metabolic process:pyridoxal phosphate binding:cofactor binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Cell motility:Cell motility:Fatty acid biosynthesis:Fatty acid biosynthesis:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Lysine biosynthesis:Lysine biosynthesis:Biotin metabolism:Biotin metabolism:Nitrogen metabolism:Nitrogen metabolism:Biosynthesis of unsaturated fatty acids:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Flagellar assembly:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:bioD:bioD:lctP:lctP:lysA:lysA:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Metabolism:Cellular Processes:Global:Carbohydrates, organic alcohols, and acids:Aspartate family:Biotin:Transport and binding proteins:Amino acid biosynthesis:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Cell Motility:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Signal Transduction:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Environmental Information Processing" 312 "" 313 "Dethiobiotin synthetase:Dethiobiotin synthetase:6-phosphofructokinase:6-phosphofructokinase:Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division:Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division:FOG: EAL domain:FOG: EAL domain:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component signal transduction system (phosphorelay):6-phosphofructokinase activity:dethiobiotin synthase activity:peroxidase activity:calcium ion binding:ATP binding:glycolysis:electron transport:regulation of transcription, DNA-dependent:response to oxidative stress:cell cycle:cell communication:biotin biosynthetic process:cyclic nucleotide biosynthetic process:phosphorus-oxygen lyase activity:peptidyl-histidine phosphorylation:heme binding:intracellular signal transduction:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Fructose and mannose metabolism:Fructose and mannose metabolism:Biotin metabolism:Biotin metabolism:Metabolic pathways:Metabolic pathways:Two-component system:Two-component system:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:GGDEF:GGDEF:bioD:bioD:Carbohydrate Metabolism:Global:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Environmental Information Processing:Signal Transduction:Other:Global:Metabolism:Metabolism:Regulatory functions:Regulatory functions:Small molecule interactions:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Signal transduction:Other:Cellular processes and signaling:Metabolism:Signal transduction:Metabolism:Signal Transduction:Metabolism of Cofactors and Vitamins:Carbohydrate Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Small molecule interactions:Biotin:Cellular processes and signaling:Metabolism:Metabolism" 314 "DNA modification methylase:DNA modification methylase:ABC-type antimicrobial peptide transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:Uncharacterized homolog of phage Mu protein gp47:Uncharacterized homolog of phage Mu protein gp47:Predicted ATPase:Predicted ATPase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Mu-like prophage DNA circulation protein:Mu-like prophage DNA circulation protein:Mu-like prophage protein gp46:Mu-like prophage protein gp46:Mu-like prophage protein gp45:Mu-like prophage protein gp45:Phage-related protein, tail component:Phage-related protein, tail component:nucleotide binding:DNA binding:ATP binding:DNA methylation:transport:N-methyltransferase activity:site-specific DNA-methyltransferase (adenine-specific) activity:ATPase activity:Replication, recombination and repair:Replication, recombination and repair:General function prediction only:General function prediction only:Function unknown:Function unknown:primase_Cterm:primase_Cterm:phage_P2_V:phage_P2_V:Defense mechanisms:Defense mechanisms:Cellular processes and signaling:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Prophage functions:Mobile and extrachromosomal element functions:Poorly characterized:Cellular processes and signaling:Information storage and processing:Poorly characterized" 315 "Energy production and conversion:Energy production and conversion:Chemotaxis protein histidine kinase and related kinases:Chemotaxis protein histidine kinase and related kinases:Biopolymer transport proteins:Biopolymer transport proteins:CMP-2-keto-3-deoxyoctulosonic acid synthetase:CMP-2-keto-3-deoxyoctulosonic acid synthetase:Micrococcal nuclease (thermonuclease) homologs:Micrococcal nuclease (thermonuclease) homologs:TRAP-type C4-dicarboxylate transport system, periplasmic component:TRAP-type C4-dicarboxylate transport system, periplasmic component:FOG: PAS/PAC domain:FOG: PAS/PAC domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase:2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase:Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain:Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain:Predicted NADH:ubiquinone oxidoreductase, subunit RnfB:Predicted NADH:ubiquinone oxidoreductase, subunit RnfB:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized conserved protein:ABC-type spermidine/putrescine transport systems, ATPase components:ABC-type spermidine/putrescine transport systems, ATPase components:Flp pilus assembly protein TadD, contains TPR repeats:Flp pilus assembly protein TadD, contains TPR repeats:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:long-chain fatty acid-CoA ligase activity:protein histidine kinase activity:alanine-tRNA ligase activity:signal transducer activity:iron ion transmembrane transporter activity:binding:ATP binding:electron transport:DNA repair:regulation of transcription, DNA-dependent:transport:iron ion transport:chemotaxis:signal transduction:transcription factor binding:metabolic process:methyltransferase activity:zinc ion binding:protein transporter activity:3-deoxy-manno-octulosonate cytidylyltransferase activity:electron carrier activity:lipopolysaccharide biosynthetic process:protein transport:putrescine-importing ATPase activity:spermidine-importing ATPase activity:polyamine transport:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:short-chain fatty acid-CoA ligase activity:medium-chain fatty acid-CoA ligase activity:very long-chain fatty acid-CoA ligase activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:kdsB:kdsB:dctP:dctP:potA:potA:C4_traR_proteo:C4_traR_proteo:tolQ:tolQ:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Transport and binding proteins:Glycan Biosynthesis and Metabolism:Membrane Transport:Signal Transduction:Cell Motility:Metabolism:Metabolism:Environmental Information Processing:Cellular Processes:Global:Small molecule interactions:Amino acids, peptides and amines:Carbohydrates, organic alcohols, and acids:Pathogenesis:Prophage functions:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Regulatory functions:Transport and binding proteins:Cellular processes:Mobile and extrachromosomal element functions:Cell envelope:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Glycan Biosynthesis and Metabolism:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:Small molecule interactions:Amino acids, peptides and amines:Carbohydrates, organic alcohols, and acids:Cellular processes:Pathogenesis:Mobile and extrachromosomal element functions:Prophage functions:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 316 "Energy production and conversion:Energy production and conversion:3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:Exoribonuclease R:Exoribonuclease R:Glycerophosphoryl diester phosphodiesterase:Glycerophosphoryl diester phosphodiesterase:Cation/multidrug efflux pump:Cation/multidrug efflux pump:Membrane-fusion protein:Membrane-fusion protein:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:Hemolysins and related proteins containing CBS domains:Hemolysins and related proteins containing CBS domains:Uncharacterized conserved protein:Uncharacterized conserved protein:Transcriptional regulator:Transcriptional regulator:ABC-type Na+ efflux pump, permease component:ABC-type Na+ efflux pump, permease component:Arabinose efflux permease:Arabinose efflux permease:Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain:Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain:Predicted ATP-grasp enzyme:Predicted ATP-grasp enzyme:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:catalytic activity:biotin synthase activity:ribonuclease activity:alanine-tRNA ligase activity:ATP binding:glycerol metabolic process:electron transport:regulation of transcription, DNA-dependent:mRNA catabolic process:transport:protein transporter activity:L-aspartate oxidase activity:exoribonuclease II activity:glycerophosphodiester phosphodiesterase activity:ribonuclease R activity:protein secretion:tetracycline:hydrogen antiporter activity:tetracycline transport:RNA metabolic process:oxidoreductase activity:specific transcriptional repressor activity:ATPase activity:ATPase activity, coupled to transmembrane movement of substances:negative regulation of transcription, DNA-dependent:response to antibiotic:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Purine metabolism:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:RNA degradation:RNA degradation:DNA replication:DNA replication:Mismatch repair:Mismatch repair:Homologous recombination:Homologous recombination:General function prediction only:General function prediction only:3_prime_RNase:3_prime_RNase:RND_mfp:RND_mfp:Defense mechanisms:Defense mechanisms:Transcription:Unknown substrate:Transcription:Degradation of RNA:Lipid Metabolism:Unknown substrate:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Degradation of RNA:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Replication and Repair:Lipid Metabolism:Folding Sorting and Degradation:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Metabolism:Transport and binding proteins:Poorly characterized:Nucleotide Metabolism:Metabolism:Cellular processes and signaling:Amino Acid Metabolism:Information storage and processing:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Transport and binding proteins:Global:Metabolism" 317 "Cobalamin biosynthesis protein CbiK, Co2+ chelatase:Cobalamin biosynthesis protein CbiK, Co2+ chelatase:sirohydrochlorin cobaltochelatase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Metabolism" 318 "Energy production and conversion:Energy production and conversion:Phosphoglucomutase:Phosphoglucomutase:2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway):2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway):Predicted rRNA methylase (SpoU class):Predicted rRNA methylase (SpoU class):Guanosine polyphosphate pyrophosphohydrolases/synthetases:Guanosine polyphosphate pyrophosphohydrolases/synthetases:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Pyrroline-5-carboxylate reductase:Pyrroline-5-carboxylate reductase:Glycine cleavage system T protein (aminomethyltransferase):Glycine cleavage system T protein (aminomethyltransferase):Deoxyribodipyrimidine photolyase:Deoxyribodipyrimidine photolyase:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:Predicted Zn-dependent peptidases, insulinase-like:Predicted Zn-dependent peptidases, insulinase-like:Actin-like ATPase involved in cell morphogenesis:Actin-like ATPase involved in cell morphogenesis:Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain:Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Organic solvent tolerance protein OstA:Organic solvent tolerance protein OstA:D-Tyr-tRNAtyr deacylase:D-Tyr-tRNAtyr deacylase:Anti-sigma regulatory factor (Ser/Thr protein kinase):Anti-sigma regulatory factor (Ser/Thr protein kinase):Serine phosphatase RsbU, regulator of sigma subunit:Serine phosphatase RsbU, regulator of sigma subunit:ATPase related to the helicase subunit of the Holliday junction resolvase:ATPase related to the helicase subunit of the Holliday junction resolvase:Septum formation initiator:Septum formation initiator:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:succinate dehydrogenase activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):cell morphogenesis:RNA binding:catalytic activity:DNA-directed DNA polymerase activity:deoxyribodipyrimidine photo-lyase activity:aminoacyl-tRNA hydrolase activity:aminomethyltransferase activity:metalloendopeptidase activity:fatty-acyl-CoA synthase activity:glycine cleavage system:long-chain fatty acid-CoA ligase activity:phosphoglucomutase activity:phosphogluconate dehydrogenase (decarboxylating) activity:protein kinase CK2 activity:phosphoprotein phosphatase activity:pyrroline-5-carboxylate reductase activity:transporter activity:ATP binding:carbohydrate metabolic process:pentose-phosphate shunt:tricarboxylic acid cycle:electron transport:DNA repair:DNA recombination:regulation of transcription, DNA-dependent:RNA processing:aminoacyl-tRNA hydrolase reaction:proteolysis:glycine catabolic process:proline biosynthetic process:fatty acid metabolic process:transport:cell cycle:metabolic process:RNA methyltransferase activity:zinc ion binding:GTP diphosphokinase activity:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity:electron carrier activity:four-way junction helicase activity:RNA modification:response to organic substance:peptide transporter activity:peptide transport:stringent response:guanosine tetraphosphate metabolic process:cellular membrane organization:amino acid binding:transferase activity:hydrolase activity, acting on ester bonds:ATPase activity:nucleoside-triphosphatase activity:glycine decarboxylation via glycine cleavage system:D-amino acid catabolic process:short-chain fatty acid-CoA ligase activity:medium-chain fatty acid-CoA ligase activity:very long-chain fatty acid-CoA ligase activity:antisigma factor binding:iron-sulfur cluster binding:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Pentose phosphate pathway:Pentose phosphate pathway:Galactose metabolism:Galactose metabolism:Fatty acid metabolism:Fatty acid metabolism:Oxidative phosphorylation:Oxidative phosphorylation:Purine metabolism:Purine metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Butanoate metabolism:Butanoate metabolism:One carbon pool by folate:One carbon pool by folate:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00046:TIGR00046:proC:proC:TIGR00256:TIGR00256:ant_ant_sig:ant_ant_sig:dhsB:dhsB:gcvT:gcvT:spoT_relA:spoT_relA:mreB:mreB:pgm:pgm:oligo_HPY:oligo_HPY:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:TCA cycle:Amino acids and amines:Global:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Biosynthesis of Other Secondary Metabolites:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Energy Metabolism:Cell envelope:Cell envelope:Amino acid biosynthesis:Cellular processes:Transport and binding proteins:Protein synthesis:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Regulatory functions:Energy metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Glutamate family:Adaptations to atypical conditions:Energy Metabolism:Amino acids, peptides and amines:Lipid Metabolism:tRNA and rRNA base modification:Nucleotide Metabolism:tRNA aminoacylation:Amino Acid Metabolism:Protein interactions:Sugars:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Amino acids and amines:TCA cycle:Sugars:Regulatory functions:Protein interactions:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Transport and binding proteins:Amino acids, peptides and amines:Cellular processes:Adaptations to atypical conditions:Amino acid biosynthesis:Glutamate family" 319 "Energy production and conversion:Energy production and conversion:F0F1-type ATP synthase, beta subunit:F0F1-type ATP synthase, beta subunit:F0F1-type ATP synthase, alpha subunit:F0F1-type ATP synthase, alpha subunit:F0F1-type ATP synthase, gamma subunit:F0F1-type ATP synthase, gamma subunit:F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit):F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit):F0F1-type ATP synthase, subunit a:F0F1-type ATP synthase, subunit a:F0F1-type ATP synthase, subunit b:F0F1-type ATP synthase, subunit b:F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein):F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein):Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Ferredoxin:Ferredoxin:Heterodisulfide reductase, subunit A and related polyferredoxins:Heterodisulfide reductase, subunit A and related polyferredoxins:Inorganic pyrophosphatase/exopolyphosphatase:Inorganic pyrophosphatase/exopolyphosphatase:Nitrate reductase gamma subunit:Nitrate reductase gamma subunit:hydrogen-transporting two-sector ATPase activity:dihydrolipoyl dehydrogenase activity:inorganic diphosphatase activity:structural molecule activity:ATP binding:electron transport:phosphorus metabolic process:hydrogen-exporting ATPase activity, phosphorylative mechanism:electron carrier activity:adenylyl-sulfate reductase activity:sulfate assimilation via adenylyl sulfate reduction:methanogenesis:ATP synthesis coupled proton transport:proton transport:sulfide oxidation, using siroheme sulfite reductase:manganese ion binding:hydrogen ion transporting ATP synthase activity, rotational mechanism:proton-transporting ATPase activity, rotational mechanism:flavin adenine dinucleotide binding:iron-sulfur cluster binding:CoB--CoM heterodisulfide reductase activity:Oxidative phosphorylation:Oxidative phosphorylation:Selenocompound metabolism:Selenocompound metabolism:Methane metabolism:Methane metabolism:Sulfur metabolism:Sulfur metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:atpA:atpA:atpD:atpD:ATP_synt_6_or_A:ATP_synt_6_or_A:ATP_synt_delta:ATP_synt_delta:ATPsyn_F1gamma:ATPsyn_F1gamma:ATP_synt_epsi:ATP_synt_epsi:aprB:aprB:aprA:aprA:Central intermediary metabolism:Sulfur metabolism:Energy metabolism:ATP-proton motive force interconversion:Metabolism:Metabolism:Metabolism:Metabolism:Energy Metabolism:Energy metabolism:Central intermediary metabolism:ATP-proton motive force interconversion:Sulfur metabolism:Global:Metabolism:Global:Metabolism:Metabolism of Other Amino Acids:Energy Metabolism:Metabolism of Other Amino Acids" 320 "Formamidopyrimidine-DNA glycosylase:Formamidopyrimidine-DNA glycosylase:FOG: PAS/PAC domain:FOG: PAS/PAC domain:Molybdopterin-binding protein:Molybdopterin-binding protein:two-component sensor activity:two-component signal transduction system (phosphorelay):DNA binding:damaged DNA binding:ATP binding:base-excision repair:nucleotide-excision repair:DNA recombination:regulation of transcription, DNA-dependent:transport:zinc ion binding:oxidized purine base lesion DNA N-glycosylase activity:cyclic nucleotide biosynthetic process:DNA integration:molybdate transmembrane-transporting ATPase activity:phosphorus-oxygen lyase activity:molybdenum ion binding:intracellular signal transduction:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Base excision repair:Base excision repair:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:fpg:fpg:Mop:Mop:Cellular processes and signaling:Replication and Repair:Genetic Information Processing:Small molecule interactions:DNA replication, recombination, and repair:Anions:Regulatory functions:DNA metabolism:Transport and binding proteins:Information storage and processing:Cellular processes and signaling:Metabolism:Genetic Information Processing:Replication and Repair:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Anions:Information storage and processing:Metabolism" 321 "Energy production and conversion:Energy production and conversion:Ni,Fe-hydrogenase I large subunit:Ni,Fe-hydrogenase I large subunit:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains:Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains:Glycerol kinase:Glycerol kinase:Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family):Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family):Signal transduction histidine kinase:Signal transduction histidine kinase:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Cation/multidrug efflux pump:Cation/multidrug efflux pump:Membrane-fusion protein:Membrane-fusion protein:Outer membrane protein:Outer membrane protein:Predicted signal transduction protein:Predicted signal transduction protein:Flp pilus assembly protein TadC:Flp pilus assembly protein TadC:Transcriptional regulator, contains sigma factor-related N-terminal domain:Transcriptional regulator, contains sigma factor-related N-terminal domain:Flp pilus assembly protein CpaB:Flp pilus assembly protein CpaB:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Flp pilus assembly protein, protease CpaA:Flp pilus assembly protein, protease CpaA:Flp pilus assembly protein, ATPase CpaE:Flp pilus assembly protein, ATPase CpaE:Flp pilus assembly protein, secretin CpaC:Flp pilus assembly protein, secretin CpaC:Flp pilus assembly protein TadB:Flp pilus assembly protein TadB:Signal transduction histidine kinase:Signal transduction histidine kinase:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):catalytic activity:glutamine-fructose-6-phosphate transaminase (isomerizing) activity:glycerol kinase activity:signal transducer activity:structural molecule activity:transporter activity:iron ion binding:ATP binding:sugar binding:carbohydrate metabolic process:amino sugar metabolic process:glycerol-3-phosphate metabolic process:electron transport:regulation of transcription, DNA-dependent:transport:chemotaxis:signal transduction:lipid binding:protein transporter activity:glycerophosphodiester phosphodiesterase activity:ferredoxin hydrogenase activity:prepilin peptidase activity:electron carrier activity:cobalamin biosynthetic process:protein secretion:carbohydrate biosynthetic process:nickel ion binding:peptidyl-histidine phosphorylation:heme binding:carbohydrate binding:transcription regulator activity:hydrogenase (acceptor) activity:cobyrinic acid a,c-diamide synthase activity:iron-sulfur cluster binding:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glycerolipid metabolism:Glycerolipid metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:HDIG:HDIG:MIP:MIP:2A0602:2A0602:glmS:glmS:glycerol_kin:glycerol_kin:TAT_signal_seq:TAT_signal_seq:RND_mfp:RND_mfp:outer_NodT:outer_NodT:pilus_cpaB:pilus_cpaB:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Defense mechanisms:Amino sugars:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Signal Transduction:Cell Motility:Metabolism:Metabolism:Environmental Information Processing:Cellular Processes:Global:Amino sugars:Other:Small molecule interactions:Protein and peptide secretion and trafficking:Unknown substrate:Porins:Central intermediary metabolism:Energy metabolism:Regulatory functions:Protein fate:Transport and binding proteins:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Energy metabolism:Other:Regulatory functions:Small molecule interactions:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Unknown substrate:Porins:Information storage and processing:Cellular processes and signaling:Metabolism" 322 "Energy production and conversion:Energy production and conversion:Fe-S oxidoreductase:Fe-S oxidoreductase:Molybdopterin biosynthesis enzyme:Molybdopterin biosynthesis enzyme:Fructose-2,6-bisphosphatase:Fructose-2,6-bisphosphatase:SAM-dependent methyltransferases:SAM-dependent methyltransferases:FOG: CheY-like receiver:FOG: CheY-like receiver:Coenzyme F390 synthetase:Coenzyme F390 synthetase:Uncharacterized MobA-related protein:Uncharacterized MobA-related protein:FOG: EAL domain:FOG: EAL domain:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):catalytic activity:signal transducer activity:electron transport:regulation of transcription, DNA-dependent:Mo-molybdopterin cofactor biosynthetic process:signal transduction:tRNA processing:metabolic process:methyltransferase activity:lipid biosynthetic process:cyclopropane-fatty-acyl-phospholipid synthase activity:electron carrier activity:sequence-specific DNA binding:flavin adenine dinucleotide binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:Poorly characterized:Cellular processes and signaling:Metabolism:Cellular processes and signaling:Poorly characterized:Metabolism" 323 "Energy production and conversion:Energy production and conversion:Alanyl-tRNA synthetase:Alanyl-tRNA synthetase:Uracil phosphoribosyltransferase:Uracil phosphoribosyltransferase:Acyl carrier protein:Acyl carrier protein:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Preprotein translocase subunit SecD:Preprotein translocase subunit SecD:RecA/RadA recombinase:RecA/RadA recombinase:ATPase components of ABC transporters with duplicated ATPase domains:ATPase components of ABC transporters with duplicated ATPase domains:Valyl-tRNA synthetase:Valyl-tRNA synthetase:Phosphoglyceromutase:Phosphoglyceromutase:Nitroreductase:Nitroreductase:Uncharacterized homolog of plant Iojap protein:Uncharacterized homolog of plant Iojap protein:Coenzyme F390 synthetase:Coenzyme F390 synthetase:Nucleotide transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:acyl carrier activity:nucleotide binding:nucleic acid binding:DNA binding:damaged DNA binding:fatty-acyl-CoA synthase activity:ribonuclease III activity:phosphoglycerate mutase activity:alanine-tRNA ligase activity:valine-tRNA ligase activity:uracil phosphoribosyltransferase activity:calcium-transporting ATPase activity:ATP binding:glucose catabolic process:glycolysis:electron transport:uracil salvage:DNA metabolic process:DNA repair:DNA recombination:alanyl-tRNA aminoacylation:valyl-tRNA aminoacylation:fatty acid biosynthetic process:intracellular protein transport:DNA-dependent ATPase activity:NADH dehydrogenase (ubiquinone) activity:metabolic process:electron carrier activity:nucleoside metabolic process:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:protein secretion by the type II secretion system:oxidoreductase activity:ATPase activity:manganese ion binding:phosphopantetheine binding:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity:phenylacetate-CoA ligase activity:cofactor binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Replication, recombination and repair:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Fatty acid biosynthesis:Fatty acid biosynthesis:Pyrimidine metabolism:Pyrimidine metabolism:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Phenylalanine metabolism:Phenylalanine metabolism:Methane metabolism:Methane metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Biosynthesis of unsaturated fatty acids:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:Homologous recombination:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:iojap_ybeB:iojap_ybeB:alaS:alaS:valS:valS:acyl_carrier:acyl_carrier:2A0604s01:2A0604s01:upp:upp:pgm_bpd_ind:pgm_bpd_ind:tigrfam_recA:tigrfam_recA:ABC_ABC_ChvD:ABC_ABC_ChvD:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Global:Metabolism:Energy metabolism:Biosynthesis:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Energy Metabolism:Carbohydrate Metabolism:Glycolysis/gluconeogenesis:Salvage of nucleosides and nucleotides:DNA replication, recombination, and repair:tRNA aminoacylation:Protein and peptide secretion and trafficking:General:Energy metabolism:Fatty acid and phospholipid metabolism:Purines, pyrimidines, nucleosides, and nucleotides:DNA metabolism:Protein synthesis:Protein fate:Unknown function:Glycolysis/gluconeogenesis:Global:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Membrane Transport:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Replication and Repair:Energy Metabolism:Folding Sorting and Degradation:Lipid Metabolism:Translation:Nucleotide Metabolism:Amino Acid Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport" 324 "Signal transduction histidine kinase:Signal transduction histidine kinase:ABC-type antimicrobial peptide transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:UTP:GlnB (protein PII) uridylyltransferase:UTP:GlnB (protein PII) uridylyltransferase:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Mu-like prophage DNA circulation protein:Mu-like prophage DNA circulation protein:Mu-like prophage tail protein gpP:Mu-like prophage tail protein gpP:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:catalytic activity:signal transducer activity:ATP binding:DNA packaging:regulation of transcription, DNA-dependent:nitrogen compound metabolic process:signal transduction:transcription factor binding:metabolic process:[protein-PII] uridylyltransferase activity:amino acid binding:ATPase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Two-component system:Two-component system:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:UTase_glnD:UTase_glnD:Defense mechanisms:Defense mechanisms:Cellular processes and signaling:Poorly characterized:Poorly characterized:Cellular processes and signaling:Signal Transduction:Regulatory functions:Small molecule interactions:Protein interactions:Environmental Information Processing:Signal Transduction:Environmental Information Processing:Regulatory functions:Protein interactions:Small molecule interactions" 325 "Ribosomal protein L22:Ribosomal protein L22:Ribosomal protein S3:Ribosomal protein S3:Ribosomal protein S8:Ribosomal protein S8:Ribosomal protein L6P/L9E:Ribosomal protein L6P/L9E:Ribosomal protein S5:Ribosomal protein S5:Ribosomal protein S17:Ribosomal protein S17:Ribosomal protein S14:Ribosomal protein S14:Ribosomal protein L29:Ribosomal protein L29:Ribosomal protein L18:Ribosomal protein L18:RNA binding:structural constituent of ribosome:translation:3-deoxy-manno-octulosonate-8-phosphatase activity:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Ribosome:Ribosome:L29:L29:L18_bact:L18_bact:rpsC_bact:rpsC_bact:rpsE_bact:rpsE_bact:rplV_bact:rplV_bact:phageSPP1_gp7:phageSPP1_gp7:S17_bact:S17_bact:L6_bact:L6_bact:Genetic Information Processing:Prophage functions:Protein synthesis:Mobile and extrachromosomal element functions:Information storage and processing:Genetic Information Processing:Translation:Protein synthesis:Ribosomal proteins: synthesis and modification:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Translation:Ribosomal proteins: synthesis and modification" 326 "Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog):Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog):Phosphoribosylamine-glycine ligase:Phosphoribosylamine-glycine ligase:NAD synthase:NAD synthase:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:Phosphatidylglycerophosphate synthase:Phosphatidylglycerophosphate synthase:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Cobalamin biosynthesis protein CobD/CbiB:Cobalamin biosynthesis protein CobD/CbiB:Uncharacterized conserved protein:Uncharacterized conserved protein:ATP-utilizing enzymes of the PP-loop superfamily:ATP-utilizing enzymes of the PP-loop superfamily:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:NAD+ synthase (glutamine-hydrolyzing) activity:glutamate synthase (NADPH) activity:phosphoribosylamine-glycine ligase activity:signal transducer activity:binding:ATP binding:electron transport:translation:glutamyl-tRNA aminoacylation:glutamate biosynthetic process:nitrogen compound metabolic process:chemotaxis:signal transduction:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity:phospholipid biosynthetic process:NAD+ synthase activity:purine base biosynthetic process:cobalamin biosynthetic process:NAD biosynthetic process:glutamate synthase (NADH) activity:oxidoreductase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:adenosylcobinamide-phosphate synthase activity:transition metal ion binding:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell motility:Cell motility:Purine metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Nicotinate and nicotinamide metabolism:Nicotinate and nicotinamide metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Nitrogen metabolism:Aminoacyl-tRNA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:gatB:gatB:nadE:nadE:pgsA:pgsA:purD:purD:gltA:gltA:C_GCAxxG_C_C:C_GCAxxG_C_C:Metabolism of Cofactors and Vitamins:Amino acid biosynthesis:Protein synthesis:Genetic Information Processing:Translation:Purines, pyrimidines, nucleosides, and nucleotides:Environmental Information Processing:Signal Transduction:Fatty acid and phospholipid metabolism:Cellular Processes:Cell Motility:Pyridine nucleotides:Global:Metabolism:Glutamate family:tRNA aminoacylation:Purine ribonucleotide biosynthesis:Biosynthesis:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:tRNA aminoacylation:Amino acid biosynthesis:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Global:Cellular Processes:Environmental Information Processing:Genetic Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Translation:Metabolism of Cofactors and Vitamins:Poorly characterized:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism:Energy Metabolism:Metabolism:Lipid Metabolism:Cellular processes and signaling:Nucleotide Metabolism:Information storage and processing:Amino Acid Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers" 327 "Energy production and conversion:Energy production and conversion:Glutamate-1-semialdehyde aminotransferase:Glutamate-1-semialdehyde aminotransferase:Adenylosuccinate lyase:Adenylosuccinate lyase:Chloride channel protein EriC:Chloride channel protein EriC:Acetyltransferase (isoleucine patch superfamily):Acetyltransferase (isoleucine patch superfamily):Anaerobic dehydrogenases, typically selenocysteine-containing:Anaerobic dehydrogenases, typically selenocysteine-containing:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:Biotin synthase and related enzymes:Biotin synthase and related enzymes:Membrane proteins related to metalloendopeptidases:Membrane proteins related to metalloendopeptidases:Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase:Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:ABC-type cobalt transport system, ATPase component:ABC-type cobalt transport system, ATPase component:Transcriptional regulators:Transcriptional regulators:Sugar transferases involved in lipopolysaccharide synthesis:Sugar transferases involved in lipopolysaccharide synthesis:Methylase involved in ubiquinone/menaquinone biosynthesis:Methylase involved in ubiquinone/menaquinone biosynthesis:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:sequence-specific DNA binding transcription factor activity:catalytic activity:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity:biotin synthase activity:metalloendopeptidase activity:voltage-gated chloride channel activity:binding:ATP binding:mitochondrial electron transport, NADH to ubiquinone:regulation of transcription, DNA-dependent:proteolysis:chloride transport:NADH dehydrogenase (ubiquinone) activity:metabolic process:methyltransferase activity:transaminase activity:lipid biosynthetic process:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity:biotin biosynthetic process:coenzyme biosynthetic process:purine ribonucleotide biosynthetic process:FMN binding:oxidoreductase activity:transferase activity, transferring acyl groups:hydrolase activity:ATPase activity:pyridoxal phosphate binding:tetrapyrrole biosynthetic process:glutamate-1-semialdehyde 2,1-aminomutase activity:sequence-specific DNA binding:undecaprenyl-phosphate galactose phosphotransferase activity:iron-sulfur cluster binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Biotin metabolism:Biotin metabolism:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:General function prediction only:General function prediction only:TIGR00423:TIGR00423:bioB:bioB:hemL:hemL:purB:purB:lipid_A_lpxA:lipid_A_lpxA:MenG_MenH_UbiE:MenG_MenH_UbiE:EpsB_2:EpsB_2:Membrane Transport:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Membrane Transport:Metabolism:Metabolism:Environmental Information Processing:Global:Purine ribonucleotide biosynthesis:Conserved:Biotin:Heme, porphyrin, and cobalamin:Menaquinone and ubiquinone:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Purines, pyrimidines, nucleosides, and nucleotides:Hypothetical proteins:Biosynthesis of cofactors, prosthetic groups, and carriers:Cell envelope:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Heme, porphyrin, and cobalamin:Menaquinone and ubiquinone:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 328 "Nitrogen regulatory protein PII:Nitrogen regulatory protein PII:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Signal transduction histidine kinase:Signal transduction histidine kinase:Nitrogenase subunit NifH (ATPase):Nitrogenase subunit NifH (ATPase):Uncharacterized protein involved in exopolysaccharide biosynthesis:Uncharacterized protein involved in exopolysaccharide biosynthesis:Mu-like prophage tail protein gpP:Mu-like prophage tail protein gpP:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:protein histidine kinase activity:transmembrane receptor protein tyrosine kinase activity:non-membrane spanning protein tyrosine kinase activity:signal transducer activity:transporter activity:ATP binding:electron transport:regulation of nitrogen utilization:transport:signal transduction:biosynthetic process:lipopolysaccharide biosynthetic process:cobalamin biosynthetic process:nitrogen fixation:nitrogenase activity:iron-iron nitrogenase activity:molybdenum-iron nitrogenase activity:vanadium-iron nitrogenase activity:peptidyl-histidine phosphorylation:enzyme regulator activity:cobyrinic acid a,c-diamide synthase activity:capsule polysaccharide biosynthetic process:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:eps_fam:eps_fam:nifH:nifH:PEP_his_kin:PEP_his_kin:pepcterm_ChnLen:pepcterm_ChnLen:pepcterm_hypo_1:pepcterm_hypo_1:Global:Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Cell envelope:Signal transduction:Central intermediary metabolism:Nitrogen fixation:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Signal transduction:Two-component systems:Xenobiotics Biodegradation and Metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Poorly characterized:Transport and binding proteins:Central intermediary metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Two-component systems:Carbohydrates, organic alcohols, and acids:Nitrogen fixation:Global:Metabolism:Metabolism:Xenobiotics Biodegradation and Metabolism:Energy Metabolism:Cell envelope:Energy Metabolism" 329 "Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:Pyruvate-formate lyase-activating enzyme:Pyruvate-formate lyase-activating enzyme:Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB:Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB:Predicted ATPase related to phosphate starvation-inducible protein PhoH:Predicted ATPase related to phosphate starvation-inducible protein PhoH:Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain):Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain):Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Lipid A core - O-antigen ligase and related enzymes:Lipid A core - O-antigen ligase and related enzymes:ABC-type molybdate transport system, permease component:ABC-type molybdate transport system, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:sequence-specific DNA binding transcription factor activity:signal transducer activity:ATP binding:carbohydrate metabolic process:glucose metabolic process:electron transport:regulation of transcription, DNA-dependent:oxygen and reactive oxygen species metabolic process:chemotaxis:signal transduction:transcription factor binding:electron carrier activity:molybdate ion transmembrane transporter activity:molybdate ion transport:cellular response to phosphate starvation:nucleoside-triphosphatase activity:[formate-C-acetyltransferase]-activating enzyme activity:4 iron, 4 sulfur cluster binding:Lipid transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Pyrimidine metabolism:Pyrimidine metabolism:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Signal transduction mechanisms:Signal transduction mechanisms:CoA_E_activ:CoA_E_activ:modB_ABC:modB_ABC:PFLE_PFLC:PFLE_PFLC:Metabolism:Transport and binding proteins:Anions:Cellular Processes:Environmental Information Processing:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Metabolism:Cellular processes and signaling:Metabolism:Nucleotide Metabolism:Environmental Information Processing:Membrane Transport:Nucleotide Metabolism:Signal Transduction:Cellular Processes:Cell Motility:Transport and binding proteins:Anions:Cellular processes and signaling" 330 "Energy production and conversion:Energy production and conversion:Dihydropteroate synthase and related enzymes:Dihydropteroate synthase and related enzymes:Topoisomerase IA:Topoisomerase IA:Superfamily II DNA/RNA helicases, SNF2 family:Superfamily II DNA/RNA helicases, SNF2 family:Helicase subunit of the DNA excision repair complex:Helicase subunit of the DNA excision repair complex:K+ transport systems, NAD-binding component:K+ transport systems, NAD-binding component:ABC-type (unclassified) transport system, ATPase component:ABC-type (unclassified) transport system, ATPase component:NADH dehydrogenase, FAD-containing subunit:NADH dehydrogenase, FAD-containing subunit:Phosphatidylglycerophosphatase A and related proteins:Phosphatidylglycerophosphatase A and related proteins:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted P-loop-containing kinase:Predicted P-loop-containing kinase:Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type):Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type):Phosphotransferase system, mannose/fructose-specific component IIA:Phosphotransferase system, mannose/fructose-specific component IIA:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:DNA topoisomerase type I activity:NADH dehydrogenase activity:dihydropteroate synthase activity:helicase activity:sugar:hydrogen symporter activity:ATP binding:DNA topological change:DNA unwinding involved in replication:nucleotide-excision repair:DNA modification:lipid metabolic process:potassium ion transport:zinc ion binding:cation transmembrane transporter activity:phosphatidylglycerophosphatase activity:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity:excinuclease ABC activity:folic acid-containing compound biosynthetic process:phosphoenolpyruvate-dependent sugar phosphotransferase system:ATPase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Fructose and mannose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Glycerophospholipid metabolism:Folate biosynthesis:Folate biosynthesis:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:Phosphotransferase system (PTS):Phosphotransferase system (PTS):Nucleotide excision repair:Nucleotide excision repair:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00159:TIGR00159:uvrb:uvrb:DHPS:DHPS:Membrane Transport:Replication and Repair:Metabolism of Cofactors and Vitamins:Lipid Metabolism:Carbohydrate Metabolism:DNA replication, recombination, and repair:Global:Conserved:Folic acid:DNA metabolism:Hypothetical proteins:Biosynthesis of cofactors, prosthetic groups, and carriers:Environmental Information Processing:Genetic Information Processing:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism" 331 "2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway):2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway):Site-specific DNA methylase:Site-specific DNA methylase:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:Ca2+/Na+ antiporter:Ca2+/Na+ antiporter:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:dTDP-D-glucose 4,6-dehydratase:dTDP-D-glucose 4,6-dehydratase:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:dTDP-glucose pyrophosphorylase:dTDP-glucose pyrophosphorylase:Uncharacterized conserved protein:Uncharacterized conserved protein:DnaK suppressor protein:DnaK suppressor protein:DNA uptake lipoprotein:DNA uptake lipoprotein:ABC-type branched-chain amino acid transport system, permease component:ABC-type branched-chain amino acid transport system, permease component:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:DNA binding:catalytic activity:signal transducer activity:transporter activity:binding:ATP binding:DNA methylation:transport:amino acid transport:chemotaxis:signal transduction:metabolic process:zinc ion binding:dTDP-4-dehydrorhamnose reductase activity:glucose-1-phosphate thymidylyltransferase activity:pyruvate, water dikinase activity:cobalamin biosynthetic process:phosphorylation:oxidoreductase activity:ATPase activity:antibiotic biosynthetic process:cobyrinic acid a,c-diamide synthase activity:cellular metabolic process:extracellular polysaccharide biosynthetic process:CDP-glucose 4,6-dehydratase activity:coenzyme binding:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates:DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Polyketide sugar unit biosynthesis:Pyruvate metabolism:Pyruvate metabolism:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:dcm:dcm:rmlA:rmlA:CDP_4_6_dhtase:CDP_4_6_dhtase:OM_YfiO:OM_YfiO:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cell envelope:Metabolism:Poorly characterized:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Signal Transduction:Membrane Transport:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Energy Metabolism:Cellular processes and signaling:Protein fate:DNA metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Protein and peptide secretion and trafficking:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:DNA replication, recombination, and repair:Metabolism of Terpenoids and Polyketides:Global:Biosynthesis of Other Secondary Metabolites:Cellular Processes:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking" 332 "ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:FOG: CheY-like receiver:FOG: CheY-like receiver:Actin-like ATPase involved in cell morphogenesis:Actin-like ATPase involved in cell morphogenesis:dTDP-glucose pyrophosphorylase:dTDP-glucose pyrophosphorylase:Predicted glycosyltransferases:Predicted glycosyltransferases:Transcriptional regulators, similar to M. xanthus CarD:Transcriptional regulators, similar to M. xanthus CarD:Predicted inhibitor of MCP methylation, homolog of CheC:Predicted inhibitor of MCP methylation, homolog of CheC:Isopentenyldiphosphate isomerase:Isopentenyldiphosphate isomerase:Predicted P-loop-containing kinase:Predicted P-loop-containing kinase:Beta-galactosidase, beta subunit:Beta-galactosidase, beta subunit:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB:Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB:DNA uptake lipoprotein:DNA uptake lipoprotein:Predicted glycosyltransferase:Predicted glycosyltransferase:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleotide binding:cell morphogenesis:sequence-specific DNA binding transcription factor activity:isopentenyl-diphosphate delta-isomerase activity:transporter activity:binding:ATP binding:regulation of transcription, DNA-dependent:transport:isoprenoid biosynthetic process:glucose-1-phosphate thymidylyltransferase activity:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity:phosphoenolpyruvate-dependent sugar phosphotransferase system:FMN binding:hydrolase activity:extracellular polysaccharide biosynthetic process:Lipid transport and metabolism:Lipid transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Fructose and mannose metabolism:Fructose and mannose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Polyketide sugar unit biosynthesis:Terpenoid backbone biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Phosphotransferase system (PTS):Phosphotransferase system (PTS):General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00022:TIGR00022:mreB:mreB:rmlA:rmlA:HEQRo_perm_3TM:HEQRo_perm_3TM:OM_YfiO:OM_YfiO:General:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Signal Transduction:Membrane Transport:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Carbohydrate Metabolism:Amino acids, peptides and amines:Protein and peptide secretion and trafficking:General:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Protein fate:Transport and binding proteins:Unknown function:Cell envelope:Global:Cellular Processes:Environmental Information Processing:Metabolism:Metabolism:Cell Motility:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Amino acids, peptides and amines:Unknown function" 333 "Ribosomal protein L14:Ribosomal protein L14:Ribosomal protein S8:Ribosomal protein S8:Ribosomal protein L6P/L9E:Ribosomal protein L6P/L9E:Ribosomal protein S17:Ribosomal protein S17:Ribosomal protein L16/L10E:Ribosomal protein L16/L10E:Ribosomal protein S14:Ribosomal protein S14:Ribosomal protein L29:Ribosomal protein L29:Ribosomal protein L18:Ribosomal protein L18:structural constituent of ribosome:translation:3-deoxy-manno-octulosonate-8-phosphatase activity:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Ribosome:Ribosome:L29:L29:L18_bact:L18_bact:rplN_bact:rplN_bact:rplP_bact:rplP_bact:phageSPP1_gp7:phageSPP1_gp7:S17_bact:S17_bact:L6_bact:L6_bact:Prophage functions:Mobile and extrachromosomal element functions:Ribosomal proteins: synthesis and modification:Information storage and processing:Genetic Information Processing:Translation:Protein synthesis:Ribosomal proteins: synthesis and modification:Mobile and extrachromosomal element functions:Prophage functions:Information storage and processing:Genetic Information Processing:Translation:Protein synthesis" 334 "Energy production and conversion:Energy production and conversion:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Polyferredoxin:Polyferredoxin:Glutamyl-tRNA reductase:Glutamyl-tRNA reductase:Uncharacterized conserved protein:Uncharacterized conserved protein:Amino acid transporters:Amino acid transporters:Amino acid permeases:Amino acid permeases:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components:ABC-type spermidine/putrescine transport system, permease component I:ABC-type spermidine/putrescine transport system, permease component I:Transcription-repair coupling factor (superfamily II helicase):Transcription-repair coupling factor (superfamily II helicase):Flagellar biosynthesis pathway, component FlhB:Flagellar biosynthesis pathway, component FlhB:Alcohol dehydrogenase, class IV:Alcohol dehydrogenase, class IV:Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain):Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain):FOG: GGDEF domain:FOG: GGDEF domain:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in archaea:Uncharacterized protein conserved in archaea:DNA G:T-mismatch repair endonuclease:DNA G:T-mismatch repair endonuclease:Predicted symporter:Predicted symporter:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Type III secretory pathway, component EscS:Type III secretory pathway, component EscS:Bacteriophage tail assembly protein:Bacteriophage tail assembly protein:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:recombinase activity:DNA binding:damaged DNA binding:sequence-specific DNA binding transcription factor activity:acid phosphatase activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:endonuclease activity:shikimate 3-dehydrogenase (NADP+) activity:aminoacyl-tRNA ligase activity:transporter activity:ATP binding:electron transport:DNA repair:mismatch repair:DNA recombination:regulation of transcription, DNA-dependent:translation:tRNA aminoacylation for protein translation:porphyrin-containing compound biosynthetic process:transport:amino acid transport:ATP-dependent helicase activity:tRNA processing:metabolic process:4-amino-4-deoxychorismate lyase activity:glutamyl-tRNA reductase activity:electron carrier activity:biosynthetic process:cyclic nucleotide biosynthetic process:protein secretion:amino acid transmembrane transporter activity:iron-chelate-transporting ATPase activity:phosphorus-oxygen lyase activity:ligase activity, forming carbon-nitrogen bonds:ATPase activity:tetrapyrrole biosynthetic process:intracellular signal transduction:metal ion binding:NADP binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell motility:Cell motility:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Fatty acid metabolism:Fatty acid metabolism:Tyrosine metabolism:Tyrosine metabolism:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Naphthalene degradation:Naphthalene degradation:Folate biosynthesis:Folate biosynthesis:Porphyrin and chlorophyll metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:Flagellar assembly:Flagellar assembly:Bacterial secretion system:Bacterial secretion system:Nucleotide excision repair:Nucleotide excision repair:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:GGDEF:GGDEF:flhB:flhB:mfd:mfd:vsr:vsr:sss:sss:araaP:araaP:hemA:hemA:fliQ_rel_III:fliQ_rel_III:cysG_Nterm:cysG_Nterm:lysidine_TilS_N:lysidine_TilS_N:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Lipid Metabolism:Genetic Information Processing:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Chemotaxis and motility:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Amino acids, peptides and amines:Cations and iron carrying compounds:Cellular processes:Pathogenesis:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cell Motility:Membrane Transport:Replication and Repair:Information storage and processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Lipid Metabolism:Carbohydrate Metabolism:Environmental Information Processing:Cellular Processes:Heme, porphyrin, and cobalamin:Global:DNA replication, recombination, and repair:tRNA and rRNA base modification:Amino acids, peptides and amines:Cations and iron carrying compounds:Pathogenesis:Signal transduction:Biosynthesis of cofactors, prosthetic groups, and carriers:Cellular processes:Transport and binding proteins:Protein synthesis:DNA metabolism:Other:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Replication and Repair:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Metabolism:Amino Acid Metabolism:Cellular Processes:Cell Motility:Metabolism:Global:Metabolism" 335 "Energy production and conversion:Energy production and conversion:Nitrogenase subunit NifH (ATPase):Nitrogenase subunit NifH (ATPase):Sugar transferases involved in lipopolysaccharide synthesis:Sugar transferases involved in lipopolysaccharide synthesis:Nitrogenase molybdenum-iron protein, alpha and beta chains:Nitrogenase molybdenum-iron protein, alpha and beta chains:Type II secretory pathway, component ExeA (predicted ATPase):Type II secretory pathway, component ExeA (predicted ATPase):Ferredoxin:Ferredoxin:two-component signal transduction system (phosphorelay):nucleotide binding:sequence-specific DNA binding transcription factor activity:DNA topoisomerase (ATP-hydrolyzing) activity:cysteine-type endopeptidase activity:transporter activity:ATP binding:carbohydrate metabolic process:electron transport:DNA topological change:regulation of transcription, DNA-dependent:proteolysis:transport:transcription factor binding:biosynthetic process:nitrogen fixation:nitrogenase activity:iron-iron nitrogenase activity:molybdenum-iron nitrogenase activity:vanadium-iron nitrogenase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds:nucleoside-triphosphatase activity:iron-sulfur cluster binding:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:nifD:nifD:nifH:nifH:pepcterm_polyde:pepcterm_polyde:EpsB_2:EpsB_2:pepcterm_ATPase:pepcterm_ATPase:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Global:Metabolism:Central intermediary metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Protein and peptide secretion and trafficking:Nitrogen fixation:Xenobiotics Biodegradation and Metabolism:Cell envelope:Energy Metabolism:Central intermediary metabolism:Nitrogen fixation:Protein fate:Protein and peptide secretion and trafficking:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Global:Cellular processes and signaling:Metabolism:Metabolism:Xenobiotics Biodegradation and Metabolism:Energy Metabolism:Metabolism:Metabolism:Protein fate" 336 "ABC-type sugar transport system, permease component:ABC-type sugar transport system, permease component:Exopolyphosphatase-related proteins:Exopolyphosphatase-related proteins:Phosphopantetheine adenylyltransferase:Phosphopantetheine adenylyltransferase:ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:ABC-type multidrug transport system, ATPase and permease components:ABC-type multidrug transport system, ATPase and permease components:ABC-type antimicrobial peptide transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:Predicted periplasmic solute-binding protein:Predicted periplasmic solute-binding protein:Lauroyl/myristoyl acyltransferase:Lauroyl/myristoyl acyltransferase:Cell shape-determining protein:Cell shape-determining protein:ABC-type phosphate/phosphonate transport system, permease component:ABC-type phosphate/phosphonate transport system, permease component:Predicted transcriptional regulator:Predicted transcriptional regulator:ABC-type transport system, involved in lipoprotein release, permease component:ABC-type transport system, involved in lipoprotein release, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:nucleic acid binding:DNA binding:pantetheine-phosphate adenylyltransferase activity:transporter activity:binding:ATP binding:regulation of transcription, DNA-dependent:transport:regulation of cell shape:4-amino-4-deoxychorismate lyase activity:lipopolysaccharide core region biosynthetic process:phosphonate transmembrane-transporting ATPase activity:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:phosphonate transport:coenzyme A biosynthetic process:transferase activity, transferring acyl groups:hydrolase activity:ATPase activity:manganese ion binding:ATPase activity, coupled to transmembrane movement of substances:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Lipopolysaccharide biosynthesis:Lipopolysaccharide biosynthesis:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:ABC transporters:ABC transporters:General function prediction only:General function prediction only:cyt_tran_rel:cyt_tran_rel:mreC:mreC:TIGR00247:TIGR00247:PhnE:PhnE:HEQRo_perm_3TM:HEQRo_perm_3TM:lolCE:lolCE:Defense mechanisms:Defense mechanisms:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Metabolism:Metabolism:Membrane Transport:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Anions:Amino acids, peptides and amines:Conserved:Biosynthesis and degradation of murein sacculus and peptidoglycan:Protein fate:Transport and binding proteins:Hypothetical proteins:Cell envelope:Protein and peptide secretion and trafficking:Global:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Amino acids, peptides and amines:Anions:Hypothetical proteins:Conserved:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing" 337 "Energy production and conversion:Energy production and conversion:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Integral membrane protein possibly involved in chromosome condensation:Integral membrane protein possibly involved in chromosome condensation:Asparagine synthase (glutamine-hydrolyzing):Asparagine synthase (glutamine-hydrolyzing):Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:dTDP-D-glucose 4,6-dehydratase:dTDP-D-glucose 4,6-dehydratase:Ferredoxin:Ferredoxin:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:Transcriptional regulator:Transcriptional regulator:Septum formation initiator:Septum formation initiator:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:pseudouridine synthesis:DNA binding:sequence-specific DNA binding transcription factor activity:RNA binding:catalytic activity:asparagine synthase (glutamine-hydrolyzing) activity:pseudouridylate synthase activity:electron transport:regulation of transcription, DNA-dependent:asparagine biosynthetic process:cell cycle:metabolic process:transaminase activity:dTDP-4-dehydrorhamnose reductase activity:electron carrier activity:RNA modification:pseudouridine synthase activity:DNA integration:specific transcriptional repressor activity:pyridoxal phosphate binding:thiamine pyrophosphate binding:cellular metabolic process:extracellular polysaccharide biosynthetic process:negative regulation of transcription, DNA-dependent:2-oxoglutarate synthase activity:CDP-glucose 4,6-dehydratase activity:coenzyme binding:iron-sulfur cluster binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:TIGR00093:TIGR00093:crcB:crcB:asn_synth_AEB:asn_synth_AEB:IV_pilin_GFxxxE:IV_pilin_GFxxxE:CDP_4_6_dhtase:CDP_4_6_dhtase:Amino acid biosynthesis:Aspartate family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Aspartate family:General:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Protein synthesis:Protein fate:Unknown function:Amino acid biosynthesis:Cell envelope:Protein and peptide secretion and trafficking:tRNA and rRNA base modification:Global:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Global:Metabolism:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Unknown function:General" 338 "Protease subunit of ATP-dependent Clp proteases:Protease subunit of ATP-dependent Clp proteases:Predicted phage phi-C31 gp36 major capsid-like protein:Predicted phage phi-C31 gp36 major capsid-like protein:Bacteriophage head-tail adaptor:Bacteriophage head-tail adaptor:proteolysis:endopeptidase Clp activity:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:General function prediction only:General function prediction only:major_cap_HK97:major_cap_HK97:gp16_SPP1:gp16_SPP1:phage_chp_gp8:phage_chp_gp8:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Prophage functions:Poorly characterized:Cellular processes and signaling:Mobile and extrachromosomal element functions:Prophage functions:Cellular processes and signaling:Poorly characterized:Mobile and extrachromosomal element functions" 339 "Putative translation initiation inhibitor, yjgF family:Putative translation initiation inhibitor, yjgF family:Glycosyltransferase:Glycosyltransferase:UDP-glucose 4-epimerase:UDP-glucose 4-epimerase:Predicted membrane protein involved in D-alanine export:Predicted membrane protein involved in D-alanine export:Transposase and inactivated derivatives:Transposase and inactivated derivatives:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Predicted helicase:Predicted helicase:DNA binding:sequence-specific DNA binding transcription factor activity:UDP-glucose 4-epimerase activity:helicase activity:endonuclease activity:transposase activity:glutamate-tRNA ligase activity:signal transducer activity:ATP binding:carbohydrate metabolic process:transposition, DNA-mediated:regulation of transcription, DNA-dependent:signal transduction:transcription factor binding:methyltransferase activity:biosynthetic process:DNA integration:hydrolase activity:nucleoside-triphosphatase activity:methylation:cellular metabolic process:coenzyme binding:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:Regulatory functions:Poorly characterized:Cellular processes and signaling:Information storage and processing:Regulatory functions:Poorly characterized:Small molecule interactions:Cellular processes and signaling:Information storage and processing:Small molecule interactions" 340 "Glycosyltransferase:Glycosyltransferase:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:DNA modification methylase:DNA modification methylase:Periplasmic protein involved in polysaccharide export:Periplasmic protein involved in polysaccharide export:Mu-like prophage tail protein gpP:Mu-like prophage tail protein gpP:Phage-related terminase:Phage-related terminase:DNA binding:catalytic activity:DNA primase activity:DNA topoisomerase (ATP-hydrolyzing) activity:receptor activity:ATP binding:electron transport:DNA replication:DNA topological change:DNA methylation:N-methyltransferase activity:zinc ion binding:site-specific DNA-methyltransferase (adenine-specific) activity:biosynthetic process:polysaccharide transmembrane transporter activity:polysaccharide transport:oxidoreductase activity:transferase activity, transferring acyl groups other than amino-acyl groups:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:General function prediction only:General function prediction only:Cellular processes and signaling:Information storage and processing:Poorly characterized:Metabolism:Cellular processes and signaling:Poorly characterized:Metabolism:Information storage and processing" 341 "Energy production and conversion:Energy production and conversion:Periplasmic serine proteases (ClpP class):Periplasmic serine proteases (ClpP class):Permeases of the drug/metabolite transporter (DMT) superfamily:Permeases of the drug/metabolite transporter (DMT) superfamily:Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains):Periplasmic protease:Periplasmic protease:ABC-type metal ion transport system, periplasmic component/surface adhesin:ABC-type metal ion transport system, periplasmic component/surface adhesin:Glucokinase:Glucokinase:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:GDP-D-mannose dehydratase:GDP-D-mannose dehydratase:Predicted glycosyltransferases:Predicted glycosyltransferases:Cold shock proteins:Cold shock proteins:TRAP-type C4-dicarboxylate transport system, large permease component:TRAP-type C4-dicarboxylate transport system, large permease component:Na+/H+ antiporter:Na+/H+ antiporter:Serine phosphatase RsbU, regulator of sigma subunit:Serine phosphatase RsbU, regulator of sigma subunit:Predicted membrane protein:Predicted membrane protein:Arabinose efflux permease:Arabinose efflux permease:Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase:Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase:Mu-like prophage DNA circulation protein:Mu-like prophage DNA circulation protein:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):DNA binding:glucokinase activity:phosphoprotein phosphatase activity:transporter activity:binding:protein binding:ATP binding:glycolysis:electron transport:regulation of transcription, DNA-dependent:proteolysis:transport:sodium ion transport:regulation of pH:response to oxidative stress:metabolic process:peptidase activity:GDP-mannose 4,6-dehydratase activity:dTDP-4-dehydrorhamnose reductase activity:lipopolysaccharide biosynthetic process:response to salt stress:sodium:hydrogen antiporter activity:oxidoreductase activity:transferase activity:transferase activity, transferring hexosyl groups:C-terminal processing peptidase activity:GDP-mannose metabolic process:carbohydrate binding:lipid glycosylation:extracellular polysaccharide biosynthetic process:coenzyme binding:Transcription:Transcription:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Fructose and mannose metabolism:Fructose and mannose metabolism:Galactose metabolism:Galactose metabolism:Starch and sucrose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:prc:prc:dctM:dctM:antiport_nhaC:antiport_nhaC:gmd:gmd:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cations and iron carrying compounds:Carbohydrates, organic alcohols, and acids:Protein modification and repair:Global:Environmental Information Processing:Metabolism:Metabolism:Energy Metabolism:Carbohydrate Metabolism:Membrane Transport:Biosynthesis of Other Secondary Metabolites:Energy Metabolism:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Protein fate:Transport and binding proteins:Cell envelope:Metabolism:Global:Membrane Transport:Environmental Information Processing:Biosynthesis of Other Secondary Metabolites:Protein fate:Protein modification and repair:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cations and iron carrying compounds:Cell envelope" 342 "Energy production and conversion:Energy production and conversion:Nucleoside-diphosphate-sugar epimerases:Nucleoside-diphosphate-sugar epimerases:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type branched-chain amino acid transport systems, periplasmic component:ADP-heptose:LPS heptosyltransferase:ADP-heptose:LPS heptosyltransferase:UDP-glucose 4-epimerase:UDP-glucose 4-epimerase:Heterodisulfide reductase, subunit A and related polyferredoxins:Heterodisulfide reductase, subunit A and related polyferredoxins:Alcohol dehydrogenase, class IV:Alcohol dehydrogenase, class IV:Uncharacterized conserved protein:Uncharacterized conserved protein:Predicted signal transduction protein:Predicted signal transduction protein:Coenzyme F420-reducing hydrogenase, delta subunit:Coenzyme F420-reducing hydrogenase, delta subunit:Heterodisulfide reductase, subunit B:Heterodisulfide reductase, subunit B:FOG: GGDEF domain:FOG: GGDEF domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:ABC-type oligopeptide transport system, periplasmic component:ABC-type oligopeptide transport system, periplasmic component:ABC-type uncharacterized transport system, duplicated ATPase component:ABC-type uncharacterized transport system, duplicated ATPase component:ABC-type uncharacterized transport system, permease component:ABC-type uncharacterized transport system, permease component:ABC-type uncharacterized transport system, permease component:ABC-type uncharacterized transport system, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:catalytic activity:UDP-glucose 4-epimerase activity:alcohol dehydrogenase activity, metal ion-independent:alcohol dehydrogenase activity, zinc-dependent:alcohol dehydrogenase activity, iron-dependent:cysteine-type endopeptidase activity:transporter activity:ATP binding:galactose metabolic process:electron transport:pyrimidine nucleotide biosynthetic process:DNA recombination:regulation of transcription, DNA-dependent:proteolysis:transport:amino acid transport:signal transduction:tRNA processing:transcription factor binding:metabolic process:dTDP-glucose 4,6-dehydratase activity:electron carrier activity:cyclic nucleotide biosynthetic process:methanogenesis:oxidoreductase activity:transferase activity:phosphorus-oxygen lyase activity:ATPase activity:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:intracellular signal transduction:cellular metabolic process:metal ion binding:transition metal ion binding:flavin adenine dinucleotide binding:coenzyme binding:iron-sulfur cluster binding:2 iron, 2 sulfur cluster binding:CoB--CoM heterodisulfide reductase activity:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Galactose metabolism:Galactose metabolism:Fatty acid metabolism:Fatty acid metabolism:Tyrosine metabolism:Tyrosine metabolism:Amino sugar and nucleotide sugar metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Polyketide sugar unit biosynthesis:Chloroalkane and chloroalkene degradation:Chloroalkane and chloroalkene degradation:Naphthalene degradation:Naphthalene degradation:Methane metabolism:Methane metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:ABC transporters:ABC transporters:General function prediction only:General function prediction only:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:GGDEF:GGDEF:galE:galE:Other:Global:Sugars:Other:Energy metabolism:Signal transduction:Metabolism:Membrane Transport:Xenobiotics Biodegradation and Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Sugars:Signal transduction:Environmental Information Processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Metabolism" 343 "ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Chemotaxis signal transduction protein:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Methyl-accepting chemotaxis protein:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:Predicted ATPase involved in cell division:Predicted ATPase involved in cell division:Predicted membrane protein:Predicted membrane protein:Predicted membrane protein:Predicted membrane protein:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Response regulator:Response regulator:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):peptidyl-prolyl cis-trans isomerase activity:cyclophilin:ATP binding:regulation of transcription, DNA-dependent:chemotaxis:signal transduction:dTDP-4-dehydrorhamnose 3,5-epimerase activity:lipopolysaccharide biosynthetic process:cyclic nucleotide biosynthetic process:phosphorus-oxygen lyase activity:ATPase activity:peptidyl-histidine phosphorylation:FK506-sensitive peptidyl-prolyl cis-trans isomerase:intracellular signal transduction:cyclophilin-type peptidyl-prolyl cis-trans isomerase activity:cell division:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Cell motility:Streptomycin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Polyketide sugar unit biosynthesis:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:ABC transporters:ABC transporters:Two-component system:Two-component system:Bacterial chemotaxis:Bacterial chemotaxis:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:sensory_box:sensory_box:FtsE:FtsE:Small molecule interactions:Global:Cell division:Cellular processes and signaling:Metabolism:Poorly characterized:Cell Motility:Signal Transduction:Membrane Transport:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Cellular Processes:Cellular processes:Small molecule interactions:Cell division:Regulatory functions:Cellular processes:Environmental Information Processing:Metabolism:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions" 344 "Energy production and conversion:Energy production and conversion:Uracil phosphoribosyltransferase:Uracil phosphoribosyltransferase:Preprotein translocase subunit SecY:Preprotein translocase subunit SecY:Translation initiation factor 1 (IF-1):Translation initiation factor 1 (IF-1):Aspartate/tyrosine/aromatic aminotransferase:Aspartate/tyrosine/aromatic aminotransferase:Aspartate carbamoyltransferase, catalytic chain:Aspartate carbamoyltransferase, catalytic chain:Uncharacterized membrane-associated protein:Uncharacterized membrane-associated protein:Na+-dependent transporters of the SNF family:Na+-dependent transporters of the SNF family:ABC-type polar amino acid transport system, ATPase component:ABC-type polar amino acid transport system, ATPase component:Integral membrane protein CcmA involved in cell shape determination:Integral membrane protein CcmA involved in cell shape determination:Long-chain fatty acid transport protein:Long-chain fatty acid transport protein:Nitrate reductase gamma subunit:Nitrate reductase gamma subunit:Xanthine/uracil permeases:Xanthine/uracil permeases:Amino acid transport and metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Nucleotide transport and metabolism:RNA binding:translation initiation factor activity:GTPase activity:L-aspartate:2-oxoglutarate aminotransferase activity:aspartate carbamoyltransferase activity:aminoacyl-tRNA ligase activity:uracil phosphoribosyltransferase activity:transporter activity:neurotransmitter:sodium symporter activity:ATP binding:electron transport:'de novo' pyrimidine base biosynthetic process:uracil salvage:translational initiation:tRNA aminoacylation for protein translation:cellular amino acid metabolic process:transport:neurotransmitter transport:protein-synthesizing GTPase activity:nitrate reductase activity:biosynthetic process:nucleoside metabolic process:protein secretion:P-P-bond-hydrolysis-driven protein transmembrane transporter activity:histidine/arginine/lysine/ornithine porter activity:arginine-importing ATPase activity:glutamine-importing ATPase activity:glutamate/aspartate porter activity:cystine/diaminopimelate porter activity:amino acid binding:ATPase activity:pyridoxal phosphate binding:Lipid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell wall/membrane/envelope biogenesis:Pyrimidine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Arginine and proline metabolism:Tyrosine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Novobiocin biosynthesis:Vitamin B6 metabolism:Vitamin B6 metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Protein export:Protein export:Bacterial secretion system:Bacterial secretion system:General function prediction only:General function prediction only:Function unknown:Function unknown:infA:infA:asp_carb_tr:asp_carb_tr:ncs2:ncs2:3a0501s007:3a0501s007:upp:upp:Intracellular trafficking, secretion, and vesicular transport:Intracellular trafficking, secretion, and vesicular transport:Amino Acid Metabolism:Biosynthesis of Other Secondary Metabolites:Folding Sorting and Degradation:Membrane Transport:Metabolism:Metabolism:Genetic Information Processing:Environmental Information Processing:Global:Pyrimidine ribonucleotide biosynthesis:Salvage of nucleosides and nucleotides:Translation factors:Protein and peptide secretion and trafficking:Nucleosides, purines and pyrimidines:Purines, pyrimidines, nucleosides, and nucleotides:Protein synthesis:Protein fate:Transport and binding proteins:Nucleotide Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Salvage of nucleosides and nucleotides:Protein synthesis:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Nucleosides, purines and pyrimidines:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism of Cofactors and Vitamins" 345 "Serine/threonine protein kinase:Serine/threonine protein kinase:Sugar phosphate isomerases/epimerases:Sugar phosphate isomerases/epimerases:Predicted helicases:Predicted helicases:Predicted periplasmic solute-binding protein:Predicted periplasmic solute-binding protein:Sulfur transfer protein involved in thiamine biosynthesis:Sulfur transfer protein involved in thiamine biosynthesis:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:ABC-type uncharacterized transport system, permease component:ABC-type uncharacterized transport system, permease component:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:two-component response regulator activity:two-component signal transduction system (phosphorelay):nucleic acid binding:DNA binding:sequence-specific DNA binding transcription factor activity:endonuclease activity:protein serine/threonine kinase activity:protein tyrosine kinase activity:transporter activity:ATP binding:electron transport:DNA repair:regulation of transcription, DNA-dependent:protein phosphorylation:sulfur compound metabolic process:transport:ATP-dependent helicase activity:transcription factor binding:electron carrier activity:oxidoreductase activity:nucleoside-triphosphatase activity:heme binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Replication, recombination and repair:Replication, recombination and repair:Sulfur relay system:Sulfur relay system:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:cas3_core:cas3_core:thiS:thiS:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Genetic Information Processing:Folding Sorting and Degradation:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis of cofactors, prosthetic groups, and carriers:Mobile and extrachromosomal element functions:Thiamine:Other:Genetic Information Processing:Folding Sorting and Degradation:Poorly characterized:Mobile and extrachromosomal element functions:Other:Biosynthesis of cofactors, prosthetic groups, and carriers" 346 "Energy production and conversion:Energy production and conversion:Fe-S oxidoreductase:Fe-S oxidoreductase:Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Phosphopantothenoylcysteine synthetase/decarboxylase:Phosphopantothenoylcysteine synthetase/decarboxylase:Universal stress protein UspA and related nucleotide-binding proteins:Universal stress protein UspA and related nucleotide-binding proteins:F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein):F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein):Predicted permeases:Predicted permeases:FOG: CheY-like receiver:FOG: CheY-like receiver:NADH:ubiquinone oxidoreductase 27 kD subunit:NADH:ubiquinone oxidoreductase 27 kD subunit:NADH:ubiquinone oxidoreductase subunit 1 (chain H):NADH:ubiquinone oxidoreductase subunit 1 (chain H):Predicted transcriptional regulator:Predicted transcriptional regulator:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Response regulator of citrate/malate metabolism:Response regulator of citrate/malate metabolism:Response regulator:Response regulator:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):sequence-specific DNA binding transcription factor activity:hydrogen-transporting two-sector ATPase activity:serine-type endopeptidase activity:phosphopantothenate--cysteine ligase activity:phosphopantothenoylcysteine decarboxylase activity:signal transducer activity:transporter activity:iron ion binding:ATP binding:electron transport:mitochondrial electron transport, NADH to ubiquinone:regulation of transcription, DNA-dependent:protein folding:protein modification process:proteolysis:transport:response to stress:signal transduction:transcription factor binding:NADH dehydrogenase (ubiquinone) activity:formate dehydrogenase (NAD+) activity:nitrate reductase activity:electron carrier activity:ATP synthesis coupled proton transport:nickel ion binding:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:heme binding:heat shock protein binding:hydrogen ion transporting ATP synthase activity, rotational mechanism:proton-transporting ATPase activity, rotational mechanism:unfolded protein binding:iron-sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Transcription:Transcription:Oxidative phosphorylation:Oxidative phosphorylation:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Metabolic pathways:General function prediction only:General function prediction only:Signal transduction mechanisms:Signal transduction mechanisms:hypA:hypA:sensory_box:sensory_box:coaBC_dfp:coaBC_dfp:rrf2_super:rrf2_super:ATP_synt_delta:ATP_synt_delta:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:General:Protein modification and repair:Small molecule interactions:ATP-proton motive force interconversion:Global:Metabolism:Metabolism:Metabolism of Cofactors and Vitamins:Energy Metabolism:Regulatory functions:Energy metabolism:Protein fate:Unknown function:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Regulatory functions:Small molecule interactions:Protein fate:Protein modification and repair:Unknown function:General" 347 "Energy production and conversion:Energy production and conversion:FAD/FMN-containing dehydrogenases:FAD/FMN-containing dehydrogenases:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Branched-chain amino acid ABC-type transport system, permease components:Branched-chain amino acid ABC-type transport system, permease components:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Sulfate permease and related transporters (MFS superfamily):Sulfate permease and related transporters (MFS superfamily):ABC-type amino acid transport system, permease component:ABC-type amino acid transport system, permease component:ABC-type transport system involved in resistance to organic solvents, ATPase component:ABC-type transport system involved in resistance to organic solvents, ATPase component:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family:Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family:ABC-type branched-chain amino acid transport system, permease component:ABC-type branched-chain amino acid transport system, permease component:Amino acid transport and metabolism:Amino acid transport and metabolism:polysaccharide biosynthetic process:alkaline phosphatase activity:carbonate dehydratase activity:dolichyl-phosphate beta-D-mannosyltransferase activity:transporter activity:ATP binding:electron transport:transport:metabolic process:methyltransferase activity:secondary active sulfate transmembrane transporter activity:sulfate transport:glycolate oxidase activity:FMN binding:peptide transporter activity:nickel-transporting ATPase activity:sulfate transmembrane-transporting ATPase activity:peptide transport:oxidoreductase activity:ATPase activity:thiosulfate transmembrane-transporting ATPase activity:flavin adenine dinucleotide binding:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:ABC transporters:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:General function prediction only:sulP:sulP:HEQRo_perm_3TM:HEQRo_perm_3TM:oligo_HPY:oligo_HPY:Amino acids, peptides and amines:Transport and binding proteins:Anions:Amino acids, peptides and amines:Environmental Information Processing:Membrane Transport:Membrane Transport:Environmental Information Processing:Poorly characterized:Poorly characterized:Metabolism:Metabolism:Transport and binding proteins:Anions" 348 "Energy production and conversion:Energy production and conversion:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Anaerobic dehydrogenases, typically selenocysteine-containing:Anaerobic dehydrogenases, typically selenocysteine-containing:Fe-S oxidoreductase:Fe-S oxidoreductase:Molybdopterin biosynthesis enzyme:Molybdopterin biosynthesis enzyme:Biotin-(acetyl-CoA carboxylase) ligase:Biotin-(acetyl-CoA carboxylase) ligase:Ni,Fe-hydrogenase I large subunit:Ni,Fe-hydrogenase I large subunit:Glycine cleavage system T protein (aminomethyltransferase):Glycine cleavage system T protein (aminomethyltransferase):Uncharacterized flavoproteins:Uncharacterized flavoproteins:Fe-S-cluster-containing hydrogenase components 1:Fe-S-cluster-containing hydrogenase components 1:Pyruvate kinase:Pyruvate kinase:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:ATPases involved in chromosome partitioning:ATPases involved in chromosome partitioning:Rhodanese-related sulfurtransferase:Rhodanese-related sulfurtransferase:FOG: CheY-like receiver:FOG: CheY-like receiver:NAD-dependent aldehyde dehydrogenases:NAD-dependent aldehyde dehydrogenases:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Actin-like ATPase involved in cell morphogenesis:Actin-like ATPase involved in cell morphogenesis:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Rubrerythrin:Rubrerythrin:Ni,Fe-hydrogenase I small subunit:Ni,Fe-hydrogenase I small subunit:Rubredoxin:Rubredoxin:Desulfoferrodoxin:Desulfoferrodoxin:Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits:Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits:Malate synthase:Malate synthase:ATPase related to the helicase subunit of the Holliday junction resolvase:ATPase related to the helicase subunit of the Holliday junction resolvase:Dihydroxyacetone kinase:Dihydroxyacetone kinase:Aldehyde:ferredoxin oxidoreductase:Aldehyde:ferredoxin oxidoreductase:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase, nitrogen specific:Delta 1-pyrroline-5-carboxylate dehydrogenase:Delta 1-pyrroline-5-carboxylate dehydrogenase:Cell cycle control, cell division, chromosome partitioning:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Carbohydrate transport and metabolism:succinate dehydrogenase activity:two-component sensor activity:two-component response regulator activity:two-component signal transduction system (phosphorelay):magnesium ion binding:cell morphogenesis:sequence-specific DNA binding transcription factor activity:1-pyrroline-5-carboxylate dehydrogenase activity:DNA-directed DNA polymerase activity:acetolactate synthase activity:aldehyde dehydrogenase [NAD(P)+] activity:aminomethyltransferase activity:biotin-[acetyl-CoA-carboxylase] ligase activity:glycerone kinase activity:glycine cleavage system:malate synthase activity:proline dehydrogenase activity:pyruvate kinase activity:thiosulfate sulfurtransferase activity:transporter activity:iron ion binding:ATP binding:glycerol metabolic process:cellular aldehyde metabolic process:glycolysis:glyoxylate cycle:tricarboxylic acid cycle:electron transport:mitochondrial electron transport, NADH to ubiquinone:DNA repair:DNA recombination:regulation of transcription, DNA-dependent:protein modification process:glutamate biosynthetic process:glycine catabolic process:proline biosynthetic process:proline catabolic process:Mo-molybdopterin cofactor biosynthetic process:transport:anion transport:NADH dehydrogenase (ubiquinone) activity:metabolic process:sulfate transport:formate dehydrogenase (NAD+) activity:ferredoxin hydrogenase activity:succinate-semialdehyde dehydrogenase [NAD(P)+] activity:electron carrier activity:cobalamin biosynthetic process:four-way junction helicase activity:FMN binding:nickel ion binding:oxidoreductase activity:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor:hydrolase activity:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides:nucleoside-triphosphatase activity:peptidyl-histidine phosphorylation:2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity:hydrogensulfite reductase activity:dissimilatory sulfate reduction:glycine decarboxylation via glycine cleavage system:heme binding:molybdenum ion binding:potassium ion binding:thiamine pyrophosphate binding:aldehyde ferredoxin oxidoreductase activity:hydrogenase (acceptor) activity:cobyrinic acid a,c-diamide synthase activity:cellular respiration:metal ion binding:transition metal ion binding:superoxide reductase activity:iron-sulfur cluster binding:4 iron, 4 sulfur cluster binding:Coenzyme transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Replication, recombination and repair:Inorganic ion transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Citrate cycle (TCA cycle):Pentose phosphate pathway:Pentose phosphate pathway:Oxidative phosphorylation:Oxidative phosphorylation:Purine metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Glycine serine and threonine metabolism:Geraniol degradation:Geraniol degradation:Valine leucine and isoleucine biosynthesis:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Arginine and proline metabolism:Glycerolipid metabolism:Glycerolipid metabolism:Pyruvate metabolism:Pyruvate metabolism:Polycyclic aromatic hydrocarbon degradation:Polycyclic aromatic hydrocarbon degradation:Naphthalene degradation:Naphthalene degradation:Glyoxylate and dicarboxylate metabolism:Glyoxylate and dicarboxylate metabolism:Nitrotoluene degradation:Nitrotoluene degradation:Butanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:C5-Branched dibasic acid metabolism:One carbon pool by folate:One carbon pool by folate:Methane metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Pantothenate and CoA biosynthesis:Biotin metabolism:Biotin metabolism:Limonene and pinene degradation:Limonene and pinene degradation:Nitrogen metabolism:Nitrogen metabolism:Metabolic pathways:Metabolic pathways:Biosynthesis of secondary metabolites:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Microbial metabolism in diverse environments:Two-component system:Two-component system:Function unknown:Function unknown:Signal transduction mechanisms:Signal transduction mechanisms:TIGR00046:TIGR00046:birA_ligase:birA_ligase:sensory_box:sensory_box:desulf_FeS4:desulf_FeS4:dhsB:dhsB:hydA:hydA:gcvT:gcvT:mreB:mreB:pyruv_kin:pyruv_kin:D1pyr5carbox2:D1pyr5carbox2:malate_syn_G:malate_syn_G:formate-DH-alph:formate-DH-alph:sdhA_frdA_Gneg:sdhA_frdA_Gneg:dsrA:dsrA:dsrB:dsrB:dhaK1:dhaK1:dha_L_ycgS:dha_L_ycgS:Information storage and processing:Carbohydrate Metabolism:Metabolism:Poorly characterized:Electron transport:Amino acids and amines:Sulfur metabolism:Global:Environmental Information Processing:Metabolism:Metabolism:Signal Transduction:Xenobiotics Biodegradation and Metabolism:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Cellular processes and signaling:Metabolism:Energy Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Lipid Metabolism:Information storage and processing:Nucleotide Metabolism:Amino Acid Metabolism:Cell envelope:Protein fate:Protein synthesis:Metabolism of Cofactors and Vitamins:Regulatory functions:Energy metabolism:Central intermediary metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis and degradation of murein sacculus and peptidoglycan:Protein modification and repair:Xenobiotics Biodegradation and Metabolism:tRNA and rRNA base modification:Small molecule interactions:TCA cycle:Environmental Information Processing:Signal Transduction:Global:Metabolism:Glycolysis/gluconeogenesis:Central intermediary metabolism:Sulfur metabolism:Energy metabolism:Amino acids and amines:Electron transport:Glycolysis/gluconeogenesis:TCA cycle:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein modification and repair:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan" 349 "Predicted amidophosphoribosyltransferases:Predicted amidophosphoribosyltransferases:nucleoside metabolic process:General function prediction only:General function prediction only:Poorly characterized:Poorly characterized"