Module Functions 1 "Energy production and conversion:Phosphate uptake regulator:MoxR-like ATPases:Methyl-accepting chemotaxis protein:6Fe-6S prismane cluster-containing protein:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Putative silver efflux pump:Uncharacterized conserved protein:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Transcription:Cell motility:Inorganic ion transport and metabolism:Nitrotoluene degradation:Methane metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:GGDEF:HDIG:radc:2A0601:CO_DH_cata:phoU_full:TIGR02270:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Global:Metabolism:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Energy Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Anions:Cations and iron carrying compounds:Hypothetical proteins:Conserved:Signal transduction:Other" 2 "Predicted transcriptional regulators:Multimeric flavodoxin WrbA:Primosomal protein N' (replication factor Y) - superfamily II helicase:Flagellar hook-associated protein:Serine phosphatase RsbU, regulator of sigma subunit:Predicted DNA-binding protein with the Helix-hairpin-helix motif:Transcription:Replication, recombination and repair:Cell motility:Flagellar assembly:Homologous recombination:General function prediction only:Signal transduction mechanisms:sensory_box:priA:flav_wrbA:GSu_C4xC__C2xCH:flgK_ends:rSAM_link_UDG:Cellular processes:Replication and Repair:Cellular Processes:Cell Motility:Energy metabolism:Electron transport:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Genetic Information Processing:Chemotaxis and motility:Unknown function:Enzymes of unknown specificity:Information storage and processing:Cellular processes and signaling:Poorly characterized" 3 "Energy production and conversion:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:(acyl-carrier-protein) S-malonyltransferase:Aspartate/tyrosine/aromatic aminotransferase:Predicted dehydrogenases and related proteins:Periplasmic protease:Predicted thioesterase:Fe-S oxidoreductase:Predicted transcriptional regulators:Uncharacterized conserved protein:Threonine aldolase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase:Cytochrome c2:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycine serine and threonine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:prc:TIGR00726:DAHP_synth_Bsub:degP_htrA_DO:Poorly characterized:Amino Acid Metabolism:Global:Metabolism:Protein fate:Degradation of proteins, peptides, and glycopeptides:Protein modification and repair:Unknown function:General:Amino acid biosynthesis:Aromatic amino acid family:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 4 "Energy production and conversion:Glutamine synthetase:Predicted Zn-dependent proteases and their inactivated homologs:Nitrogen regulatory protein PII:Predicted phosphatases:Glycerol kinase:Parvulin-like peptidyl-prolyl isomerase:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Transcription-repair coupling factor (superfamily II helicase):N-acetylglutamate synthase and related acetyltransferases:Uncharacterized conserved protein:Predicted signal transduction protein:Uncharacterized protein conserved in bacteria:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase:Tfp pilus assembly protein, tip-associated adhesin PilY1:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Signal transduction histidine kinase regulating phosphoglycerate transport system:Predicted membrane protein:Signal transduction histidine kinase:Gas vesicle protein:Amino acid transport and metabolism:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Glycerolipid metabolism:Glyoxylate and dicarboxylate metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Nucleotide excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:GGDEF:HDIG:mfd:GlnA:glycerol_kin:DAHP_synth_Bsub:HAD-SF-IA-v3:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Signal transduction:Glutamate family:Aromatic amino acid family:Amino acid biosynthesis:Enzymes of unknown specificity:Unknown function:DNA replication, recombination, and repair:DNA metabolism:Small molecule interactions:Regulatory functions:Other:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism" 5 "Energy production and conversion:Enolase:Predicted S-adenosylmethionine-dependent methyltransferase:Acyl carrier protein:3-oxoacyl-(acyl-carrier-protein) synthase:Preprotein translocase subunit SecF:Preprotein translocase subunit SecD:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Glycyl-tRNA synthetase, beta subunit:Bacterial nucleoid DNA-binding protein:Preprotein translocase subunit YajC:Cytochrome b subunit of formate dehydrogenase:3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase:Cytochrome c biogenesis factor:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Fatty acid biosynthesis:Lipopolysaccharide biosynthesis:Pyruvate metabolism:Methane metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:TIGR00091:glyS:acyl_carrier:yajC:2A0604s01:eno:KDO8P_synth:pyru_phos_dikin:fabF:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cell envelope:Protein and peptide secretion and trafficking:Protein fate:tRNA and rRNA base modification:tRNA aminoacylation:Protein synthesis:Biosynthesis:Fatty acid and phospholipid metabolism:Other:Glycolysis/gluconeogenesis:Energy metabolism:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Translation:Genetic Information Processing:Glycan Biosynthesis and Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism" 6 "Single-stranded DNA-binding protein:Transcriptional regulator:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Predicted metal-dependent hydrolase of the TIM-barrel fold:Predicted ATPase (AAA+ superfamily):Hemerythrin:Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit:Cytochrome c biogenesis factor:Signal transduction histidine kinase:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Signal transduction mechanisms:sensory_box:ssb:paired_CXXCH_1:hemeryth_dom:Poorly characterized:Replication and Repair:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Information storage and processing:Cellular processes and signaling:Metabolism:Genetic Information Processing" 7 "1-acyl-sn-glycerol-3-phosphate acyltransferase:Ribonuclease HI:Aspartate/tyrosine/aromatic aminotransferase:Membrane GTPase LepA:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type transport system involved in resistance to organic solvents, permease component:Cell division protein FtsI/penicillin-binding protein 2:Predicted hydrolase (HAD superfamily):NAD(FAD)-utilizing enzyme possibly involved in translation:Predicted periplasmic solute-binding protein:Cell shape-determining protein:Tfp pilus assembly protein PilN:Tfp pilus assembly protein PilO:Membrane-bound metallopeptidase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Peptidoglycan biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:DNA replication:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:TIGR00056:gid_trmFO:mreC:small_GTP:TIGR00247:HAD-SF-IA-v3:pbp2_mrdA:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Lipid Metabolism:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Replication and Repair:Global:Metabolism:Protein synthesis:tRNA and rRNA base modification:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:General:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 8 "Energy production and conversion:Glucose-6-phosphate isomerase:Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:Uncharacterized membrane-associated protein:Predicted permease:Predicted membrane metal-binding protein:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:HD-GYP domain:Uncharacterized protein conserved in bacteria:ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:gidB:HDIG:ComEC_N-term:CydC:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:General:Unknown function:tRNA and rRNA base modification:Protein synthesis:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Carbohydrate Metabolism" 9 "Energy production and conversion:Transketolase:Acetyl-CoA acetyltransferase:Glycosidases:Glycosyltransferases involved in cell wall biogenesis:Translation elongation factors (GTPases):Sugar kinases, ribokinase family:ABC-type antimicrobial peptide transport system, permease component:Signal transduction histidine kinase:Phosphoglyceromutase:ABC-type transport system involved in cytochrome c biogenesis, permease component:Periplasmic protein TonB, links inner and outer membranes:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Lauroyl/myristoyl acyltransferase:Uncharacterized conserved protein:Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases:FOG: GGDEF domain:O-acetylhomoserine sulfhydrylase:CO dehydrogenase maturation factor:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Cysteine and methionine metabolism:Starch and sucrose metabolism:Lipopolysaccharide biosynthesis:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:small_GTP:tktlase_bact:GGDEF:pgm_bpd_ind:OAH_OAS_sulfhy:tonB_Cterm:treS_nterm:Defense mechanisms:Amino acid biosynthesis:General:Unknown function:Cations and iron carrying compounds:Transport and binding proteins:Biosynthesis and degradation of polysaccharides:Pentose phosphate pathway:Glycolysis/gluconeogenesis:Energy metabolism:Metabolism:Metabolism:Global:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Signal transduction:Serine family" 10 "Energy production and conversion:Ribosomal protein S7:GTPases - translation elongation factors:Ribosomal protein S10:F0F1-type ATP synthase, alpha subunit:Ribosomal protein L1:Ribosomal protein L3:Ribosomal protein L2:Ribosomal protein L5:Ribosomal protein S13:Ribosomal protein L15:DNA-directed RNA polymerase, alpha subunit/40 kD subunit:F0F1-type ATP synthase, gamma subunit:Ribosomal protein L18:Ribosomal protein L33:Ribosomal protein S4 and related proteins:Translation, ribosomal structure and biogenesis:Transcription:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:Ribosome:RNA polymerase:L18_bact:small_GTP:atpA:rpsD_bact:rpmG_bact:rpsG_bact:rpsJ_bact:rplO_bact:ATPsyn_F1gamma:rplA_bact:rplB_bact:rpoA:L3_bact:bact_S13:General:Energy Metabolism:Nucleotide Metabolism:Genetic Information Processing:Transcription:Translation:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Transcription:DNA-dependent RNA polymerase:Protein synthesis:Ribosomal proteins: synthesis and modification:Unknown function:Metabolism:Information storage and processing:Metabolism" 11 "Energy production and conversion:Xaa-Pro aminopeptidase:NAD synthase:Panthothenate synthetase:Uncharacterized flavoproteins:Nucleoside-diphosphate-sugar epimerases:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:Mg2+ and Co2+ transporters:Predicted phosphoesterase:ABC-type amino acid transport system, permease component:Bacterial nucleoid DNA-binding protein:Enoyl-CoA hydratase/carnithine racemase:Phosphomannomutase:ABC-type transport system involved in resistance to organic solvents, ATPase component:Uncharacterized distant relative of homeotic protein bithoraxoid:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Ribosomal protein L11 methylase:Uncharacterized protein conserved in bacteria:Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain:Uncharacterized conserved protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Fructose and mannose metabolism:beta-Alanine metabolism:Amino sugar and nucleotide sugar metabolism:Glyoxylate and dicarboxylate metabolism:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Nicotinate and nicotinamide metabolism:Pantothenate and CoA biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Ribosome:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:panC:S21p:yfcE:corA:nadE:HEQRo_perm_3TM:paired_CXXCH_1:Metabolism:Cellular processes and signaling:Information storage and processing:Pyridine nucleotides:Pantothenate and coenzyme A:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function:Cations and iron carrying compounds:Amino acids, peptides and amines:Transport and binding proteins:Ribosomal proteins: synthesis and modification:Protein synthesis:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism" 12 "Chemotaxis signal transduction protein:ABC-type cobalt transport system, ATPase component:ABC-type antimicrobial peptide transport system, ATPase component:Micrococcal nuclease (thermonuclease) homologs:Precorrin-6B methylase 1:Coenzyme transport and metabolism:Replication, recombination and repair:Cell motility:Inorganic ion transport and metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:ABC transporters:Two-component system:Bacterial chemotaxis:Signal transduction mechanisms:cbiO:CbiE:Defense mechanisms:Transport and binding proteins:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Metabolism:Cations and iron carrying compounds:Information storage and processing:Cellular processes and signaling:Metabolism" 13 "Energy production and conversion:5-enolpyruvylshikimate-3-phosphate synthase:Mannose-6-phosphate isomerase:ABC-type polar amino acid transport system, ATPase component:Deoxyxylulose-5-phosphate synthase:Uncharacterized protein conserved in bacteria:Pyruvate-formate lyase:Transposase and inactivated derivatives:Molybdopterin converting factor, small subunit:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Copper chaperone:Predicted transcriptional regulator:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Pyruvate metabolism:Propanoate metabolism:Butanoate metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:dxs:aroA:moaD_arch:Poorly characterized:Metabolism:Information storage and processing:Thiamine:Molybdopterin:Biosynthesis of cofactors, prosthetic groups, and carriers:Aromatic amino acid family:Amino acid biosynthesis:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Amino Acid Metabolism:Carbohydrate Metabolism" 14 "Energy production and conversion:Predicted Co/Zn/Cd cation transporters:Dihydrofolate reductase:Kef-type K+ transport systems, membrane components:Universal stress protein UspA and related nucleotide-binding proteins:Predicted permeases:Predicted xylanase/chitin deacetylase:Periplasmic protein TonB, links inner and outer membranes:Methyl-accepting chemotaxis protein:Cation/multidrug efflux pump:Flagellar motor switch protein:Outer membrane protein:NADH:flavin oxidoreductases, Old Yellow Enzyme family:Ni,Fe-hydrogenase I cytochrome b subunit:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Signal transduction histidine kinase:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:One carbon pool by folate:Folate biosynthesis:Metabolic pathways:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Signal transduction mechanisms:fliG:tonB_Cterm:CytB-hydogenase:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Chemotaxis and motility:Cellular processes:Cations and iron carrying compounds:Transport and binding proteins:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins" 15 "Glutamyl- and glutaminyl-tRNA synthetases:Diaminopimelate decarboxylase:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Leucyl-tRNA synthetase:Superfamily II DNA and RNA helicases:FKBP-type peptidyl-prolyl cis-trans isomerases 1:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type transport system involved in cytochrome c biogenesis, permease component:Parvulin-like peptidyl-prolyl isomerase:Membrane protein TerC, possibly involved in tellurium resistance:Predicted ATP-dependent serine protease:ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains):Actin-like ATPase involved in cell morphogenesis:Metal-dependent hydrolases of the beta-lactamase superfamily I:Amidases related to nicotinamidase:Type II secretory pathway, prepilin signal peptidase PulO and related peptidases:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:leuS_bact:sms:glnS:recB:nspC:lysidine_TilS_N:R_switched_Alx:queuosine_YadB:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Central intermediary metabolism:Polyamine biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 16 "Energy production and conversion:DnaJ-class molecular chaperone with C-terminal Zn finger domain:Superfamily II DNA and RNA helicases:NADPH:quinone reductase and related Zn-dependent oxidoreductases:ABC-type branched-chain amino acid transport systems, periplasmic component:UDP-3-O-acyl-N-acetylglucosamine deacetylase:Cation/multidrug efflux pump:Membrane-fusion protein:Actin-like ATPase involved in cell morphogenesis:ABC-type phosphate transport system, ATPase component:6Fe-6S prismane cluster-containing protein:Protoporphyrinogen oxidase:Cold shock proteins:Uncharacterized membrane protein, required for colicin V production:Outer membrane protein:Arabinose efflux permease:Predicted acetyltransferase:Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit:Gluconolactonase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Lipopolysaccharide biosynthesis:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:lpxC:proto_IX_ox:2A0602:3a0107s01c2:hybrid_clust:RND_mfp:outer_NodT:oxido_YhdH:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Cellular processes and signaling:Energy Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Amino acids and amines:Transport and binding proteins:Unknown substrate:Anions:Porins:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 17 "Putative translation factor (SUA5):Peptidyl-tRNA hydrolase:Transcription antiterminator:Glycosyltransferase:Predicted Zn-dependent peptidases:Exopolyphosphatase-related proteins:Signal transduction histidine kinase:Predicted glycosyltransferases:Type II secretory pathway, component PulF:FOG: GGDEF domain:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:DNA-binding transcriptional activator of the SARP family:Tfp pilus assembly protein, ATPase PilM:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Metabolic pathways:General function prediction only:Signal transduction mechanisms:TIGR00057:sensory_box:pth:nusG:Intracellular trafficking, secretion, and vesicular transport:Small molecule interactions:Regulatory functions:Information storage and processing:Metabolism:Cellular processes and signaling:Poorly characterized:General:Global:Unknown function:Other:Protein synthesis:Transcription factors:Transcription" 18 "Energy production and conversion:Predicted membrane protein:Signal transduction histidine kinase:F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein):ABC-type amino acid transport system, permease component:NADH:ubiquinone oxidoreductase subunit 3 (chain A):Membrane protein TerC, possibly involved in tellurium resistance:Cold shock proteins:Predicted transcriptional regulators:Type II secretory pathway, component PulF:Uncharacterized conserved protein:DnaK suppressor protein:4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Cell motility:Inorganic ion transport and metabolism:Oxidative phosphorylation:Glycerolipid metabolism:Glycerophospholipid metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Function unknown:Signal transduction mechanisms:TIGR00023:ispE:ATP_synt_delta:HEQRo_perm_3TM:casB_cse2:Intracellular trafficking, secretion, and vesicular transport:Transport and binding proteins:Biosynthesis:Fatty acid and phospholipid metabolism:ATP-proton motive force interconversion:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism of Terpenoids and Polyketides:Lipid Metabolism:Amino acids, peptides and amines:Energy Metabolism:Mobile and extrachromosomal element functions:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 19 "Predicted GTPase:Dihydropteroate synthase and related enzymes:Predicted metal-dependent hydrolase:Transcription elongation factor:Signal transduction protein containing GAF and PtsI domains:Coenzyme transport and metabolism:Transcription:Folate biosynthesis:Metabolic pathways:Phosphotransferase system (PTS):General function prediction only:Signal transduction mechanisms:TIGR00043:small_GTP:PTS_I_fam:greA:DHPS:Poorly characterized:Other:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:Transcription:Transcription factors:Protein synthesis:Metabolism:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Information storage and processing:Cellular processes and signaling:Metabolism" 20 "ATP-dependent Lon protease, bacterial type:ATPase components of ABC transporters with duplicated ATPase domains:S-adenosylhomocysteine hydrolase:DNA polymerase III, alpha subunit:Predicted Zn-dependent peptidases:Hypoxanthine-guanine phosphoribosyltransferase:ABC-type transport system involved in resistance to organic solvents, permease component:Acetyl-CoA carboxylase alpha subunit:Membrane-fusion protein:Predicted ATP-dependent protease:ABC-type transport system involved in resistance to organic solvents, periplasmic component:Ribonucleases G and E:Predicted CoA-binding protein:Trehalose-6-phosphatase:Osmosensitive K+ channel histidine kinase:Na+/H+ antiporter:Opacity protein and related surface antigens:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Starch and sucrose metabolism:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:RNA degradation:DNA replication:Mismatch repair:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:TIGR00056:accA:polc:RNaseEG:lon:ahcY:RND_mfp:GSu_C4xC__C2xCH:IV_pilin_GFxxxE:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Amino acids and amines:Energy metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Other Amino Acids:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Fatty acid and phospholipid metabolism:Carbohydrate Metabolism:Biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Unknown substrate:Hypothetical proteins:Conserved" 21 "Energy production and conversion:Succinyl-CoA synthetase, beta subunit:Ni,Fe-hydrogenase I large subunit:Uncharacterized conserved protein:ATPases with chaperone activity, ATP-binding subunit:Predicted permeases:FOG: CheY-like receiver:Fe-S oxidoreductase:Metal-dependent hydrolases of the beta-lactamase superfamily III:Predicted HD superfamily hydrolase:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Regulator of cell morphogenesis and NO signaling:Uncharacterized protein conserved in bacteria:Lignostilbene-alpha,beta-dioxygenase and related enzymes:Signal transduction histidine kinase:Cell cycle control, cell division, chromosome partitioning:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Propanoate metabolism:C5-Branched dibasic acid metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00149_YbjQ:sensory_box:HDIG:sucCoAbeta:TAT_signal_seq:VI_ClpV1:VI_chp_3:FeS_repair_RIC:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:TCA cycle:Regulatory functions:Small molecule interactions:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Pathogenesis:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Cellular processes and signaling:Metabolism:Metabolism" 22 "Uncharacterized conserved protein:Function unknown:sensory_box:Regulatory functions:Small molecule interactions:Poorly characterized" 23 "Energy production and conversion:Acetate kinase:Molybdopterin biosynthesis enzyme:Molybdenum cofactor biosynthesis enzyme:Membrane protease subunits, stomatin/prohibitin homologs:Glycosidases:NADH:ubiquinone oxidoreductase 49 kD subunit 7:Permeases of the drug/metabolite transporter (DMT) superfamily:NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K):NADH:ubiquinone oxidoreductase subunit 1 (chain H):NADH:ubiquinone oxidoreductase subunit 4 (chain M):ABC-type Mn/Zn transport systems, ATPase component:NADH:ubiquinone oxidoreductase 24 kD subunit:Tfp pilus assembly protein, tip-associated adhesin PilY1:Flagellar basal body rod protein:Tfp pilus assembly protein FimT:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Taurine and hypotaurine metabolism:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Flagellar assembly:Sulfur relay system:General function prediction only:ackA:molyb_syn:moaC:GSu_C4xC__C2xCH:nuoB_fam:NDH_I_M:flgG_G_neg:IV_pilin_GFxxxE:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Electron transport:Fermentation:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Cellular processes and signaling:Metabolism:Poorly characterized" 24 "GTPases - translation elongation factors:Ribosomal protein S11:DNA-directed RNA polymerase, alpha subunit/40 kD subunit:Ribosomal protein L33:Translation, ribosomal structure and biogenesis:Transcription:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:Ribosome:RNA polymerase:small_GTP:rpmG_bact:rpoA:bact_S11:Transcription:DNA-dependent RNA polymerase:Protein synthesis:Ribosomal proteins: synthesis and modification:Unknown function:General:Information storage and processing:Metabolism:Global:Translation:Transcription:Genetic Information Processing:Metabolism:Nucleotide Metabolism" 25 "Glucan phosphorylase:Superfamily II DNA and RNA helicases:FOG: Ankyrin repeat:Periplasmic protease:Methyl-accepting chemotaxis protein:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Saccharopine dehydrogenase and related proteins:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Lysine biosynthesis:Lysine degradation:Starch and sucrose metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Base excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:prc:more_P_ylases:Metabolism:Metabolism:Metabolism:Global:Cellular processes and signaling:Cell Motility:Cellular Processes:Information storage and processing:Protein modification and repair:Protein fate:Signal Transduction:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Amino Acid Metabolism:Poorly characterized:Carbohydrate Metabolism" 26 "Ribosomal protein S18:Phosphate/sulphate permeases:Pseudouridylate synthases, 23S RNA-specific:Methyl-accepting chemotaxis protein:Cation/multidrug efflux pump:BioD-like N-terminal domain of phosphotransacetylase:Preprotein translocase subunit SecG:Beta-lactamase class C and other penicillin binding proteins:FOG: GGDEF domain:Predicted membrane protein:Translation, ribosomal structure and biogenesis:Cell motility:Inorganic ion transport and metabolism:Two-component system:Bacterial chemotaxis:Ribosome:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:S18:sensory_box:GGDEF:secG:2A0602:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Poorly characterized:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Regulatory functions:Small molecule interactions:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Unknown substrate:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Genetic Information Processing" 27 "Energy production and conversion:Nitrogen regulatory protein PII:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Cation transport ATPase:Na+-driven multidrug efflux pump:Membrane-fusion protein:ADP-heptose:LPS heptosyltransferase:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit:Deoxyxylulose-5-phosphate synthase:Ferritin-like protein:Outer membrane protein:Uncharacterized conserved protein:Putative silver efflux pump:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized metal-binding protein conserved in archaea:Uncharacterized conserved small protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Valine leucine and isoleucine biosynthesis:Pyruvate metabolism:Butanoate metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:matE:2A0601:ATPase_P-type:RND_mfp:PDH_E1_alph_x:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Poorly characterized:Metabolism:Cellular processes and signaling:Other:Cations and iron carrying compounds:Unknown substrate:Transport and binding proteins:Pyruvate dehydrogenase:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Carbohydrate Metabolism" 28 "Glycine/serine hydroxymethyltransferase:Fructose/tagatose bisphosphate aldolase:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted dehydrogenases and related proteins:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:Collagenase and related proteases:ABC-type multidrug transport system, ATPase and permease components:Lysyl-tRNA synthetase (class II):Type II secretory pathway, component PulD:Type II secretory pathway, component PulF:3-deoxy-D-manno-octulosonic-acid transferase:Tetraacyldisaccharide-1-P 4'-kinase:Threonine aldolase:Type II secretory pathway, pseudopilin PulG:Outer membrane protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Fatty acid biosynthesis:Glycine serine and threonine metabolism:Lipopolysaccharide biosynthesis:One carbon pool by folate:Methane metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Bacterial secretion system:General function prediction only:Function unknown:lysS_bact:lpxK:fabZ:GspF:MsbA_lipidA:type_II_gspD:IV_pilin_GFxxxE:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Lipid Metabolism:tRNA aminoacylation:Energy Metabolism:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Other:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Protein synthesis" 29 "Indole-3-glycerol phosphate synthase:3-oxoacyl-[acyl-carrier-protein] synthase III:ADP-heptose:LPS heptosyltransferase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Predicted RNA-binding protein containing KH domain, possibly ribosomal protein:Predicted membrane protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Fatty acid biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:RNA_bind_YhbY:fabH:3oxo_ACP_reduc:Information storage and processing:Lipid Metabolism:Amino Acid Metabolism:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Unknown function:General:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 30 "Energy production and conversion:Alanyl-tRNA synthetase:Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Mg-dependent DNase:Phosphoribosylaminoimidazole (AIR) synthetase:Phosphoribosylamine-glycine ligase:Protoheme ferro-lyase (ferrochelatase):Cobalamin-5-phosphate synthase:Signal transduction histidine kinase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1:NAD(FAD)-utilizing enzyme possibly involved in translation:Inactive homolog of metal-dependent proteases, putative molecular chaperone:Predicted periplasmic solute-binding protein:Cobyrinic acid a,c-diamide synthase:Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase:Methylase involved in ubiquinone/menaquinone biosynthesis:ABC-type transport system involved in resistance to organic solvents, auxiliary component:Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta):Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:TIGR00010:hemH:gid_trmFO:sensory_box:cobS:alaS:cobB:purD:purM:purE:MenG_MenH_UbiE:pyruv_ox_red:bact_YeaZ:tRNA and rRNA base modification:tRNA aminoacylation:Protein synthesis:Small molecule interactions:Regulatory functions:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Cellular processes and signaling:Nucleotide Metabolism:Metabolism:Poorly characterized:Information storage and processing:Menaquinone and ubiquinone:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function" 31 "Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:Uncharacterized conserved protein:Glycogen synthase:ABC-type branched-chain amino acid transport systems, ATPase component:Nucleoside-diphosphate-sugar epimerases:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Prolipoprotein diacylglyceryltransferase:Penicillin tolerance protein:ABC-type transport system involved in resistance to organic solvents, permease component:CMP-2-keto-3-deoxyoctulosonic acid synthetase:Predicted glycosyltransferases:Putative transcriptional regulator, homolog of Bvg accessory factor:Septum formation initiator:ABC-type uncharacterized transport system, periplasmic component:Cell division protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Purine metabolism:Starch and sucrose metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Lipopolysaccharide biosynthesis:Pantothenate and CoA biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:TIGR00056:ispH_lytB:kdsB:lgt:baf:TIGR01033:gyrB:apt:glgA:Information storage and processing:Carbohydrate Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:Regulatory functions:DNA interactions:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein modification and repair:Hypothetical proteins:Conserved:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Pantothenate and coenzyme A:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 32 "Energy production and conversion:Chloride channel protein EriC:Phosphotransacetylase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Glutamate dehydrogenase/leucine dehydrogenase:Recombinational DNA repair protein (RecF pathway):Acetyl-CoA hydrolase:Small-conductance mechanosensitive channel:Uncharacterized membrane protein (homolog of Drosophila rhomboid):FOG: CheY-like receiver:Transcriptional regulator:Outer membrane receptor proteins, mostly Fe transport:Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB:Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain):Homoserine acetyltransferase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Nitrate/nitrite transporter:Permeases:Predicted membrane protein:Predicted symporter:Kef-type K+ transport system, predicted NAD-binding component:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Taurine and hypotaurine metabolism:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Sulfur metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:CoA_E_activ:recR:pta:sss:homoserO_Ac_trn:Fermentation:Energy metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Metabolism:Signal Transduction:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Metabolism of Other Amino Acids:Amino Acid Metabolism:Energy Metabolism:Cations and iron carrying compounds:Carbohydrate Metabolism:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Transport and binding proteins:DNA replication, recombination, and repair:DNA metabolism:Small molecule interactions:Regulatory functions" 33 "Glycosyltransferase:Predicted glycosyltransferases:Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation):Retron-type reverse transcriptase:Protein involved in cellulose biosynthesis (CelD):Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Metabolic pathways:Protein export:Bacterial secretion system:General function prediction only:tatAE:prismane_assoc:Protein fate:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Genetic Information Processing:Protein and peptide secretion and trafficking:Information storage and processing:Cellular processes and signaling:Poorly characterized" 34 "tRNA delta(2)-isopentenylpyrophosphate transferase:Zn-dependent hydrolases, including glyoxylases:Na+-driven multidrug efflux pump:Predicted metal-dependent hydrolase with the TIM-barrel fold:Translation, ribosomal structure and biogenesis:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:miaA:matE:Defense mechanisms:Information storage and processing:Metabolism:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Other:Global:Cellular processes and signaling:Poorly characterized" 35 "Energy production and conversion:Predicted GTPase, probable translation factor:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:Predicted GTPase:Ribosomal protein L28:Glycerol-3-phosphate dehydrogenase:Phosphoribosylpyrophosphate synthetase:RecA/RadA recombinase:Phosphatidylglycerophosphate synthase:Periplasmic serine proteases (ClpP class):Single-stranded DNA-binding protein:RNase PH:Fe2+/Zn2+ uptake regulation proteins:Bacterial nucleoid DNA-binding protein:Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis:Lactate dehydrogenase and related dehydrogenases:D-alanine-D-alanine ligase and related ATP-grasp enzymes:Predicted metal-binding, possibly nucleic acid-binding protein:Predicted metal-dependent hydrolase:Uncharacterized conserved protein:DnaK suppressor protein:Leucyl aminopeptidase (aminopeptidase T):ABC-type uncharacterized transport system, periplasmic component:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase regulating citrate/malate metabolism:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Purine metabolism:Glycine serine and threonine metabolism:D-Alanine metabolism:Peptidoglycan biosynthesis:Glycerophospholipid metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:L28:TIGR00092:sensory_box:small_GTP:pgsA:ispG_gcpE:ssb:SppA_dom:D_ala_D_alaTIGR:ribP_PPkin:RNasePH:tigrfam_recA:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Transcription:RNA processing:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Degradation of proteins, peptides, and glycopeptides:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 36 "Superfamily II DNA and RNA helicases:Periplasmic serine proteases (ClpP class):ABC-type transport system involved in cytochrome c biogenesis, permease component:Methyl-accepting chemotaxis protein:Lysine efflux permease:Methylase of chemotaxis methyl-accepting proteins:Predicted membrane protein:Predicted membrane protein:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:SppA_dom:casD_Cas5e:casA_cse1:stabl_TIGR02574:Intracellular trafficking, secretion, and vesicular transport:Environmental Information Processing:Poorly characterized:Cellular processes and signaling:Information storage and processing:Other:Mobile and extrachromosomal element functions:Degradation of proteins, peptides, and glycopeptides:Cell Motility:Cellular Processes:Protein fate:Signal Transduction" 37 "Methionine aminopeptidase:Ribosomal protein L4:Ribosomal protein L23:Ribosomal protein L22:Ribosomal protein S3:Ribosomal protein L14:Ribosomal protein S8:Ribosomal protein L6P/L9E:Ribosomal protein S5:Seryl-tRNA synthetase:Ribosomal protein S19:Ribosomal protein S17:Ribosomal protein L16/L10E:Ribosomal protein L24:Ribosomal protein L29:Ribosomal protein L21:Translation elongation factors (GTPases):Adenylate kinase and related kinases:Ribosomal protein L30/L7E:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Purine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:L29:L21:small_GTP:serS:met_pdase_I:rpsC_bact:rpsE_bact:rplV_bact:rpsS_bact:rplN_bact:rplX_bact:rplP_bact:rpmD_bact:adk:S17_bact:L6_bact:rplD_bact:Information storage and processing:Nucleotide Metabolism:Genetic Information Processing:Translation:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Protein fate:Protein modification and repair:Unknown function:General:Metabolism:Metabolism" 38 "Energy production and conversion:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Excinuclease ATPase subunit:Fe-S oxidoreductase:FAD/FMN-containing dehydrogenases:tRNA nucleotidyltransferase/poly(A) polymerase:Glutamate racemase:Metal-dependent hydrolases of the beta-lactamase superfamily III:Methionine synthase I, cobalamin-binding domain:Predicted HD superfamily hydrolase:Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB:Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain):SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Uncharacterized conserved protein:Thiosulfate reductase cytochrome B subunit (membrane anchoring protein):Amino acid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cysteine and methionine metabolism:Histidine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Selenocompound metabolism:D-Glutamine and D-glutamate metabolism:Polycyclic aromatic hydrocarbon degradation:Glyoxylate and dicarboxylate metabolism:One carbon pool by folate:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:Nucleotide excision repair:General function prediction only:Function unknown:glut_race:CoA_E_activ:HDIG:rumA:uvra:hisC:tonB_Cterm:paired_CXXCH_1:PEP_exosort:Biosynthesis and degradation of murein sacculus and peptidoglycan:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Cations and iron carrying compounds:Amino acid biosynthesis:Histidine family:Cell envelope:Metabolism:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 39 "ATP phosphoribosyltransferase:Ketol-acid reductoisomerase:Dihydroxyacid dehydratase/phosphogluconate dehydratase:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:Fructose/tagatose bisphosphate aldolase:Aspartate/tyrosine/aromatic aminotransferase:Carbamoylphosphate synthase small subunit:Aspartate carbamoyltransferase, catalytic chain:Holliday junction resolvasome, DNA-binding subunit:Signal transduction histidine kinase:Phosphatidylserine decarboxylase:Transcription elongation factor:FOG: CheY-like receiver:Uncharacterized conserved protein:Predicted O-linked N-acetylglucosamine transferase, SPINDLY family:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Histidine metabolism:Glycerophospholipid metabolism:One carbon pool by folate:Carbon fixation pathways in prokaryotes:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Homologous recombination:Function unknown:Signal transduction mechanisms:hisG:ruvA:ilvD:PS_decarb_rel:sensory_box:ilvC:asp_carb_tr:gyrB:CPSaseIIsmall:DAPAT_plant:Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Unknown function:General:Amino acid biosynthesis:Pyruvate family:Histidine family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 40 "Energy production and conversion:Predicted rRNA methylase (SpoU class):Conserved domain frequently associated with peptide methionine sulfoxide reductase:Formamidopyrimidine-DNA glycosylase:3-oxoacyl-(acyl-carrier-protein) synthase:Lipoate-protein ligase B:Thiol-disulfide isomerase and thioredoxins:Predicted phosphatases:Uncharacterized conserved protein:Signal transduction histidine kinase:Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit:Membrane-bound serine protease (ClpP class):Uncharacterized conserved protein:Uncharacterized conserved protein:NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit:Uncharacterized conserved protein, contains double-stranded beta-helix domain:Cation transport ATPase:Coenzyme F420-reducing hydrogenase, alpha subunit:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Uncharacterized conserved protein:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Oxidative phosphorylation:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Lipoic acid metabolism:Metabolic pathways:Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:tRNA_TruD_broad:lipB:sensory_box:TIGR00357:fpg:TIGR00726:HAD-SF-IA-v3:ATPase-IB1_Cu:Enzymes of unknown specificity:Unknown function:Adaptations to atypical conditions:Cellular processes:Cations and iron carrying compounds:Transport and binding proteins:Protein modification and repair:Protein fate:tRNA and rRNA base modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Small molecule interactions:Regulatory functions:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Lipid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:General" 41 "Thiamine monophosphate synthase:Signal transduction histidine kinase:Predicted SAM-dependent methyltransferases:Flagellin and related hook-associated proteins:Flagellar hook-basal body protein:Uncharacterized conserved protein:Uncharacterized protein involved in exopolysaccharide biosynthesis:ABC-type phosphate/phosphonate transport system, periplasmic component:Uncharacterized conserved protein:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Thiamine metabolism:Metabolic pathways:Two-component system:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:fliE:sensory_box:thiE:cas_GSU0054:cas_GSU0053:FlgM_jcvi:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:Small molecule interactions:Cellular processes:Chemotaxis and motility:Mobile and extrachromosomal element functions:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Cellular processes and signaling:Metabolism:Metabolism" 42 "Energy production and conversion:Ribonuclease HII:Hydrogenase maturation factor:Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase:Nucleotide-binding protein implicated in inhibition of septum formation:Pseudouridylate synthases, 23S RNA-specific:Glycerol-3-phosphate dehydrogenase:Signal transduction histidine kinase:N-acetylmuramoyl-L-alanine amidase:Fe-S oxidoreductase:Rubredoxin:Uncharacterized host factor I protein:Putative NADPH-quinone reductase (modulator of drug activity B):Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase:Cell cycle control, cell division, chromosome partitioning:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycerophospholipid metabolism:RNA degradation:DNA replication:General function prediction only:Function unknown:Signal transduction mechanisms:hypB:hypC_hupF:maf:sensory_box:Hfq:Regulatory functions:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Cellular processes and signaling:Lipid Metabolism:Metabolism:Poorly characterized:Information storage and processing:Cell division:Cellular processes:Protein modification and repair:Protein fate:Metabolism:Small molecule interactions:Other" 43 "Energy production and conversion:Predicted sugar kinase:Fe-S oxidoreductase:Aspartate/tyrosine/aromatic aminotransferase:Predicted GTPase:ATPase involved in DNA repair:Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit:Single-stranded DNA-specific exonuclease:Enoyl-[acyl-carrier-protein] reductase (NADH):Multimeric flavodoxin WrbA:Glycyl-tRNA synthetase, alpha subunit:NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Tyrosine metabolism:Phenylalanine metabolism:Benzoate degradation:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Nicotinate and nicotinamide metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Base excision repair:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:small_GTP:glyQ:redox_disulf_2:recN:recJ:ahpD_dom:Unknown function:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Metabolism:General:Information storage and processing:Metabolism:Poorly characterized" 44 "2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway):Porphobilinogen deaminase:Glutamyl-tRNA reductase:Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase:Hydrogenase maturation factor:Superfamily II DNA helicase:ABC-type transport system involved in cytochrome c biogenesis, permease component:Peroxiredoxin:Outer membrane protein:Uncharacterized conserved protein:Uncharacterized enzyme of thiazole biosynthesis:Opacity protein and related surface antigens:Gas vesicle protein:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Thiamine metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:hypB:hypD:hemC:recQ_fam:hemA:thioredoxin:cytochr_II_ccsB:Intracellular trafficking, secretion, and vesicular transport:Protein modification and repair:Protein fate:DNA replication, recombination, and repair:DNA metabolism:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Genetic Information Processing:Metabolism:Metabolism of Cofactors and Vitamins:Poorly characterized:Cellular processes and signaling:Information storage and processing:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers" 45 "Predicted phosphatase/phosphohexomutase:FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains):Predicted GTPases:Exonuclease V gamma subunit:Subtilisin-like serine proteases:Predicted transcriptional regulators:Site-specific recombinases, DNA invertase Pin homologs:SOS-response transcriptional repressors (RecA-mediated autopeptidases):Uncharacterized protein conserved in bacteria:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Two-component system:Bacterial chemotaxis:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00157:lexA:recB:recC:B_ant_repeat:HAD-SF-IA-v3:Unknown function:Translation factors:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:DNA interactions:Regulatory functions:Genetic Information Processing:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Information storage and processing:Replication and Repair:Cellular processes and signaling:Poorly characterized:Enzymes of unknown specificity" 46 "Energy production and conversion:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:FOG: TPR repeat:Translation elongation factors (GTPases):S-adenosylhomocysteine hydrolase:Signal transduction histidine kinase:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:Inorganic pyrophosphatase/exopolyphosphatase:Disulfide bond chaperones of the HSP33 family:Amidases related to nicotinamidase:Uncharacterized protein conserved in bacteria:Nicotinic acid phosphoribosyltransferase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Predicted ATPase:ABC-type uncharacterized transport system, periplasmic component:Putative silver efflux pump:ABC-type uncharacterized transport system, permease component:Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain:Site-specific recombinase XerD:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Cysteine and methionine metabolism:Selenocompound metabolism:One carbon pool by folate:Carbon fixation pathways in prokaryotes:Nicotinate and nicotinamide metabolism:Metabolic pathways:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00093:small_GTP:2A0601:ahcY:NAPRTase_put:GSu_C4xC__C2xCH:paired_CXXCH_1:recomb_XerC:tRNA_sel_U_synt:General:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Amino acids and amines:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Cations and iron carrying compounds:Unknown function:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 47 "Predicted rRNA methylase (SpoU class):Trehalose-6-phosphate synthase:Predicted acid phosphatase:Anthranilate/para-aminobenzoate synthases component II:Phosphoglycerate mutase 1:2-methylthioadenine synthetase:Glutaredoxin and related proteins:Predicted permeases:Predicted hydrolase (HAD superfamily):Sugar phosphate isomerases/epimerases:Predicted glycosyltransferases:Uncharacterized stress-induced protein:Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family:Ketopantoate reductase:FOG: GGDEF domain:Hemerythrin:Transposase and inactivated derivatives:Uncharacterized protein conserved in bacteria:Predicted permease, DMT superfamily:Membrane carboxypeptidase/penicillin-binding protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Purine metabolism:Pyrimidine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Starch and sucrose metabolism:Peptidoglycan biosynthesis:Methane metabolism:Nicotinate and nicotinamide metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:surE:TIGR00089:GGDEF:TIGR00255:trpG_papA:apbA_panE:pgm_1:HAD-SF-IA-v3:PBP_1a_fam:GlrX_YruB:hemeryth_dom:TIGR02757:Cellular processes:Metabolism:Metabolism:Global:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Pantothenate and coenzyme A:Carbohydrate Metabolism:Signal transduction:Other:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function:Conserved:Hypothetical proteins:Adaptations to atypical conditions" 48 "ATPases of the AAA+ class:Parvulin-like peptidyl-prolyl isomerase:Subtilisin-like serine proteases:FOG: PKD repeat:Phage tail sheath protein FI:Phage baseplate assembly protein W:Posttranslational modification, protein turnover, chaperones:General function prediction only:TIGR02241:TIGR02243:Poorly characterized:Cellular processes and signaling:Prophage functions:Mobile and extrachromosomal element functions" 49 "Energy production and conversion:ATPases of the AAA+ class:Cation transport ATPase:Thiol-disulfide isomerase and thioredoxins:ABC-type amino acid transport system, permease component:Chemotaxis signal transduction protein:Heme/copper-type cytochrome/quinol oxidases, subunit 1:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Membrane-bound serine protease (ClpP class):Predicted ATP-dependent protease:ATPase components of various ABC-type transport systems, contain duplicated ATPase:Transcriptional regulator:Archaeal S-adenosylmethionine synthetase:Heme/copper-type cytochrome/quinol oxidase, subunit 3:Uncharacterized conserved protein:K+-transporting ATPase, c chain:Osmosensitive K+ channel histidine kinase:HD-GYP domain:Nitrate/nitrite transporter:K+ transporter:Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains:Site-specific recombinase XerD:Uncharacterized integral membrane protein:Amino acid transport and metabolism:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Cysteine and methionine metabolism:Selenocompound metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:kdpC:ATPase_P-type:HEQRo_perm_3TM:recomb_XerC:caa3_sub_IV:CtaD_CoxA:Poorly characterized:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Electron transport:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Amino acids, peptides and amines:Cations and iron carrying compounds:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 50 "Energy production and conversion:Ribosomal protein S16:Co-chaperonin GroES (HSP10):Uroporphyrinogen-III decarboxylase:Chaperonin GroEL (HSP60 family):Mg2+ and Co2+ transporters:Predicted phosphoesterase:Cell wall-associated hydrolases (invasion-associated proteins):Fe-S oxidoreductase:GTPase SAR1 and related small G proteins:Phosphomannomutase:ABC-type (unclassified) transport system, ATPase component:DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog:Uncharacterized protein conserved in bacteria:Ribosomal protein L11 methylase:Sporulation protein and related proteins:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Amino sugar and nucleotide sugar metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Ribosome:RNA degradation:RNA polymerase:General function prediction only:Function unknown:S16:yfcE:corA:rlpA:hemE:GroEL:rpoN_sigma:SpoIID_LytB:outer_YhbN_LptA:exo_TIGR04073:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Transcription factors:Transcription:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Metabolism:Translation:Transcription:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Protein synthesis:Carbohydrate Metabolism:Ribosomal proteins: synthesis and modification:Protein fate:Protein folding and stabilization:Transport and binding proteins:Cations and iron carrying compounds:Other:Unknown function:Enzymes of unknown specificity:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Other" 51 "Energy production and conversion:Dihydrofolate reductase:Zn-dependent protease with chaperone function:GMP synthase, PP-ATPase domain/subunit:tRNA nucleotidyltransferase/poly(A) polymerase:Predicted permease:Glutaredoxin and related proteins:FOG: CheY-like receiver:Mannose-1-phosphate guanylyltransferase:Hydrolases of the alpha/beta superfamily:FOG: HEAT repeat:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Precorrin-2 methylase:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Predicted membrane protein:Predicted membrane protein:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Fructose and mannose metabolism:Purine metabolism:Amino sugar and nucleotide sugar metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:RNA degradation:General function prediction only:Function unknown:Signal transduction mechanisms:GGDEF:guaA_Cterm:cobI_cbiL:GSu_C4xC__C2xCH:pcnB:GlrX_YruB:type_IV_pilB:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Information storage and processing:Carbohydrate Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Other:Signal transduction:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:Protein and peptide secretion and trafficking:Protein fate:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides" 52 "Energy production and conversion:Arginyl-tRNA synthetase:ATP phosphoribosyltransferase:Adenylosuccinate synthase:Homoserine dehydrogenase:Signal transduction histidine kinase:ABC-type dipeptide transport system, periplasmic component:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Peroxiredoxin:Coenzyme F390 synthetase:TRAP-type C4-dicarboxylate transport system, large permease component:Predicted HD-superfamily hydrolase:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:Predicted ATP-dependent Lon-type protease:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Histidine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Signal transduction mechanisms:hisG:purA:HDIG:argS:dctM:Lon_rel_chp:Poorly characterized:Transport and binding proteins:tRNA aminoacylation:Protein synthesis:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Amino Acid Metabolism:Carbohydrates, organic alcohols, and acids:Nucleotide Metabolism:Hypothetical proteins:Conserved:Amino acid biosynthesis:Histidine family:Information storage and processing:Cellular processes and signaling:Metabolism" 53 "Molecular chaperone (small heat shock protein):Imidazoleglycerol-phosphate synthase:Predicted N6-adenine-specific DNA methylase:Aminopeptidase N:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):Signal transduction histidine kinase:Membrane-fusion protein:Predicted membrane GTPase involved in stress response:Transcriptional regulator:Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Uncharacterized conserved protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:TRAP-type uncharacterized transport system, periplasmic component:Uncharacterized conserved protein:Uncharacterized iron-regulated protein:Starvation-inducible outer membrane lipoprotein:Predicted periplasmic ligand-binding sensor domain:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase:Signal transduction histidine kinase:Amino acid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Histidine metabolism:Glutathione metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:RNA polymerase:General function prediction only:Function unknown:Signal transduction mechanisms:YbaK_EbsC:sensory_box:small_GTP:ant_ant_sig:hisF:RND_mfp:TRAP_TAXI:RpoD_Cterm:pepN_proteo:General:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Transcription:Environmental Information Processing:Signal Transduction:Global:Metabolism:Regulatory functions:Protein interactions:Small molecule interactions:Transcription:Transcription factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Unknown substrate:Unknown function:Metabolism:Amino acid biosynthesis:Histidine family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 54 "Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:AraC-type DNA-binding domain-containing proteins:Predicted membrane protein:Outer membrane receptor for ferrienterochelin and colicins:Coenzyme transport and metabolism:Transcription:Inorganic ion transport and metabolism:General function prediction only:Function unknown:TIGR00423:Hypothetical proteins:Metabolism:Information storage and processing:Conserved:Poorly characterized" 55 "Chemotaxis protein histidine kinase and related kinases:ABC-type branched-chain amino acid transport systems, periplasmic component:Phosphomannomutase:Predicted metal-dependent hydrolase with the TIM-barrel fold:Outer membrane receptor for ferrienterochelin and colicins:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Cell motility:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:General function prediction only:Signal transduction mechanisms:Cellular processes and signaling:Carbohydrate Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Metabolism:Metabolism:Poorly characterized" 56 "Energy production and conversion:Pseudouridylate synthase:Aspartate-semialdehyde dehydrogenase:F0F1-type ATP synthase, gamma subunit:Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):Ribosomal protein L20:Ribosomal protein L9:Fatty acid/phospholipid biosynthesis enzyme:Cold shock proteins:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Oxidative phosphorylation:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:Function unknown:S21p:efp:hisT_truA:tsf:L9:plsX:rplT_bact:ATPsyn_F1gamma:asd_gamma:tRNA and rRNA base modification:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Fatty acid and phospholipid metabolism:Biosynthesis:Protein synthesis:Ribosomal proteins: synthesis and modification:Metabolism:Translation factors:Amino acid biosynthesis:Aspartate family:Information storage and processing:Metabolism:Poorly characterized" 57 "Energy production and conversion:Glucan phosphorylase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Predicted amidohydrolase:Molecular chaperone:DnaJ-class molecular chaperone with C-terminal Zn finger domain:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):Predicted Zn-dependent peptidases:6-pyruvoyl-tetrahydropterin synthase:Nitroreductase:Methyl-accepting chemotaxis protein:Biopolymer transport protein:Long-chain acyl-CoA synthetases (AMP-forming):Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Transcriptional regulator:Predicted oxidoreductases of the aldo/keto reductase family:Chemotaxis protein; stimulates methylation of MCP proteins:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Putative virion core protein (lumpy skin disease virus):Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Fatty acid metabolism:Starch and sucrose metabolism:Glycerophospholipid metabolism:Thiamine metabolism:Folate biosynthesis:Metabolic pathways:Bacterial chemotaxis:RNA degradation:RNA polymerase:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:tonB_Cterm:more_P_ylases:DnaJ_bact:prok_dnaK:rpoH_proteo:CxxC_CxxC_SSSS:tolR:queuosine_QueD:Intracellular trafficking, secretion, and vesicular transport:Cations and iron carrying compounds:Carbohydrate Metabolism:Lipid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Folding Sorting and Degradation:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:DNA interactions:Transcription:Transcription factors:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein folding and stabilization:Transport and binding proteins:Metabolism:Cellular processes:Pathogenesis:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 58 "Ribosomal protein S7:Ribosomal protein S10:Ribosomal protein L11:Ribosomal protein L1:Ribosomal protein L3:Ribosomal protein L2:Ribosomal protein L5:Ribosomal protein S13:Ribosomal protein L13:Ribosomal protein S9:Ribosomal protein L15:Ribosomal protein L27:Ribosomal protein L7/L12:Ribosomal protein L10:Ribosomal protein L18:Ribosomal protein L9:Ribosomal protein S6:Ribosomal protein S4 and related proteins:Preprotein translocase subunit SecE:ATP-dependent protease Clp, ATPase subunit:Uncharacterized conserved protein:Translation, ribosomal structure and biogenesis:Posttranslational modification, protein turnover, chaperones:Ribosome:Protein export:Bacterial secretion system:Function unknown:L18_bact:L27:L9:S6:clpX:L12:secE_bact:rpsD_bact:rpsG_bact:rpsJ_bact:rplM_bact:rplO_bact:rplA_bact:rplB_bact:L11_bact:L3_bact:bact_S13:Intracellular trafficking, secretion, and vesicular transport:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Information storage and processing:Cellular processes and signaling:Poorly characterized:Genetic Information Processing:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Translation" 59 "Energy production and conversion:Fe-S oxidoreductase:FAD/FMN-containing dehydrogenases:Predicted permease:FOG: CheY-like receiver:Chemotaxis signal transduction protein:Membrane protein TerC, possibly involved in tellurium resistance:Fe-S oxidoreductase:Predicted amidophosphoribosyltransferases:Hydrolases of the alpha/beta superfamily:Uncharacterized conserved protein containing a ferredoxin-like domain:Metal-dependent hydrolases of the beta-lactamase superfamily III:Uncharacterized conserved protein:L-lactate permease:3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases:Transcriptional accessory protein:Cation transport ATPase:Lignostilbene-alpha,beta-dioxygenase and related enzymes:Putative silver efflux pump:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Lipid transport and metabolism:Transcription:Cell motility:Inorganic ion transport and metabolism:Valine leucine and isoleucine degradation:Glyoxylate and dicarboxylate metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:GGDEF:2A0601:TAT_signal_seq:ATPase-IB1_Cu:R_switched_Alx:Metabolism:Global:Cell Motility:Cellular Processes:Metabolism:Signal Transduction:Environmental Information Processing:Amino Acid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Signal transduction:Cations and iron carrying compounds:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate" 60 "Peptide methionine sulfoxide reductase:N-formylmethionyl-tRNA deformylase:Glutamyl-tRNA reductase:Nucleoside-diphosphate-sugar epimerases:Predicted Fe-S oxidoreductases:Bacterial cell division membrane protein:GDP-D-mannose dehydratase:Outer membrane protein:Uncharacterized conserved protein:Cytochrome c peroxidase:Sulfur transfer protein involved in thiamine biosynthesis:Anaerobic C4-dicarboxylate transporter:ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase:Predicted acetyltransferase:Predicted signal transduction protein containing EAL and modified HD-GYP domains:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Sulfur relay system:General function prediction only:Function unknown:Signal transduction mechanisms:pept_deformyl:cyt_tran_rel:msrA:Dcu:hemA:thioredoxin:gmd:thiS:ftsW:rSAM_more_4Fe4S:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Carbohydrate Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Electron transport:Protein fate:Protein modification and repair:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cellular processes:Cell division:Adaptations to atypical conditions:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Thiamine:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 61 "Energy production and conversion:Helicase subunit of the DNA excision repair complex:Metal-dependent hydrolases of the beta-lactamase superfamily II:Cytochrome b subunit of the bc complex:Amidases related to nicotinamidase:Uncharacterized conserved protein:Predicted peroxiredoxins:Uncharacterized protein involved in exopolysaccharide biosynthesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Oxidative phosphorylation:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Nucleotide excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:uvrb:Cellular processes and signaling:Energy Metabolism:Genetic Information Processing:Replication and Repair:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 62 "Energy production and conversion:Diaminopimelate decarboxylase:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase:Ribosomal protein S16:Ribosomal protein L32:F0F1-type ATP synthase, subunit a:Aspartate/tyrosine/aromatic aminotransferase:CTP synthase (UTP-ammonia lyase):Predicted integral membrane protein:FKBP-type peptidyl-prolyl cis-trans isomerases 2:GTPase SAR1 and related small G proteins:ABC-type transport system involved in resistance to organic solvents, periplasmic component:Predicted RNA-binding protein (contains KH domain):Transposase and inactivated derivatives:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Arginine and proline metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:S16:purC:PyrG:rpmF_bact:lysA:ATP_synt_6_or_A:GAPDH-I:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Glycolysis/gluconeogenesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:Protein synthesis:Ribosomal proteins: synthesis and modification:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 63 "Energy production and conversion:Glutamate synthase domain 2:Predicted amidohydrolase:Zn-dependent protease with chaperone function:Methyl-accepting chemotaxis protein:Ferredoxin:Predicted glycosyltransferases:Predicted signal transduction protein:Peptidylarginine deiminase and related enzymes:Maltooligosyl trehalose synthase:Signal transduction histidine kinase:Conserved secreted protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Cell motility:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:trehalose_TreY:Metabolism:Cellular processes and signaling:Small molecule interactions:Regulatory functions:Biosynthesis and degradation of polysaccharides:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Amino Acid Metabolism:Poorly characterized:Energy Metabolism" 64 "Energy production and conversion:Ammonia permease:Isopropylmalate/homocitrate/citramalate synthases:Nitrogen regulatory protein PII:Predicted Fe-S oxidoreductases:Signal transduction histidine kinase:ABC-type molybdate transport system, periplasmic component:FKBP-type peptidyl-prolyl cis-trans isomerases 2:Nitrogenase subunit NifH (ATPase):Uncharacterized conserved protein:Uncharacterized conserved protein:Nitrogenase molybdenum-iron protein, alpha and beta chains:Response regulator with putative antiterminator output domain:ABC-type molybdate transport system, permease component:Amino acid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Lysine biosynthesis:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00159:amt:modA:nifD:nifE:nifK:nifH:modB_ABC:nifV_homocitr:nifX:fdxN_nitrog:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Nitrogen fixation:Transport and binding proteins:Anions:Cations and iron carrying compounds:Hypothetical proteins:Conserved:Cellular processes and signaling:Metabolism:Poorly characterized" 65 "Energy production and conversion:Catalase (peroxidase I):Uncharacterized conserved protein:Predicted permease:ABC-type branched-chain amino acid transport systems, periplasmic component:MoxR-like ATPases:NAD-dependent aldehyde dehydrogenases:Hemolysins and related proteins containing CBS domains:Transcriptional regulator:Periplasmic protein involved in polysaccharide export:Rubredoxin:Cytochrome c peroxidase:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Uncharacterized conserved protein:Predicted N-acetylglucosaminyl transferase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Phenylalanine metabolism:Tryptophan metabolism:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Base excision repair:General function prediction only:Function unknown:cat_per_HPI:PEP_exosort:PEP_TPR_lipo:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Surface structures:Cell envelope:Detoxification:Cellular processes:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism" 66 "Acetyl-CoA acetyltransferase:UDP-N-acetyl-D-mannosaminuronate dehydrogenase:Long-chain acyl-CoA synthetases (AMP-forming):Transcriptional regulator:Lauroyl/myristoyl acyltransferase:FOG: GGDEF domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized protein involved in exopolysaccharide biosynthesis:Uncharacterized conserved protein:Predicted membrane protein:Uncharacterized protein conserved in bacteria, putative lipoprotein:Alpha-tubulin suppressor and related RCC1 domain-containing proteins:Cell cycle control, cell division, chromosome partitioning:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Fatty acid metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Metabolic pathways:Function unknown:Signal transduction mechanisms:GGDEF:NDP-sugDHase:Cytoskeleton:Lipid Metabolism:Cellular processes and signaling:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Information storage and processing:Other:Signal transduction:Metabolism:Global:Glycan Biosynthesis and Metabolism" 67 "3,4-dihydroxy-2-butanone 4-phosphate synthase:Riboflavin synthase alpha chain:Multimeric flavodoxin WrbA:Phosphopantetheinyl transferase (holo-ACP synthase):N6-adenine-specific methylase:Predicted membrane-associated Zn-dependent proteases 1:Cell division protein FtsI/penicillin-binding protein 2:Predicted ATPase or kinase:Pyridoxal phosphate biosynthesis protein:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase:Putative threonine efflux protein:4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Predicted membrane protein:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Fatty acid biosynthesis:Lipopolysaccharide biosynthesis:Peptidoglycan biosynthesis:Riboflavin metabolism:Vitamin B6 metabolism:Pantothenate and CoA biosynthesis:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Two-component system:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00054:TIGR00095:HI0065_YjeE:ribE:ribA:acpS:pdxJ:cztS_silS_copS:3oxo_ACP_reduc:lipid_A_lpxD:type_II_gspE:pbp2_mrdA:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Poorly characterized:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Lipid Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Protein synthesis:tRNA and rRNA base modification:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Pathogenesis:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridoxine:Riboflavin, FMN, and FAD:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling" 68 "Purine nucleoside phosphorylase:Exopolyphosphatase:Aspartate/tyrosine/aromatic aminotransferase:Glycosyltransferases involved in cell wall biogenesis:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Predicted hydrolase (HAD superfamily):Transposase and inactivated derivatives:Membrane protein involved in the export of O-antigen and teichoic acid:Uncharacterized protein conserved in bacteria:Retron-type reverse transcriptase:Predicted O-methyltransferase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:HAD-SF-IA-v3:MTAP:Salvage of nucleosides and nucleotides:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Biosynthesis of Other Secondary Metabolites:Amino Acid Metabolism:Information storage and processing:Nucleotide Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Enzymes of unknown specificity:Unknown function" 69 "Helicase subunit of the DNA excision repair complex:Universal stress protein UspA and related nucleotide-binding proteins:FOG: CheY-like receiver:Metal-dependent hydrolases of the beta-lactamase superfamily II:Beta-lactamase class C and other penicillin binding proteins:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Replication, recombination and repair:Nucleotide excision repair:General function prediction only:Signal transduction mechanisms:uvrb:stabl_TIGR02574:Defense mechanisms:Poorly characterized:Replication and Repair:DNA metabolism:DNA replication, recombination, and repair:Mobile and extrachromosomal element functions:Other:Information storage and processing:Cellular processes and signaling:Genetic Information Processing" 70 "Translation initiation factor 1 (IF-1):Predicted acid phosphatase:Single-stranded DNA-binding protein:Bacterial nucleoid DNA-binding protein:Methyl-accepting chemotaxis protein:4-alpha-glucanotransferase:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Hemerythrin:Predicted membrane protein:Uncharacterized protein conserved in bacteria:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Uncharacterized protein conserved in bacteria:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell motility:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Starch and sucrose metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:infA:surE:malQ:GGDEF:rumA:ssb:hemeryth_dom:VI_chp_7:Signal transduction:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Translation factors:Cellular processes:Adaptations to atypical conditions:Pathogenesis:Metabolism:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 71 "Energy production and conversion:Translation initiation factor 1 (eIF-1/SUI1) and related proteins:Histidinol dehydrogenase:Anthranilate/para-aminobenzoate synthases component I:Phosphoheptose isomerase:Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division:Zn-dependent hydrolases, including glyoxylases:Zn-dependent protease with chaperone function:FOG: CheY-like receiver:Arsenite efflux pump ACR3 and related permeases:Membrane protein TerC, possibly involved in tellurium resistance:Hydrolases of the alpha/beta superfamily:Dioxygenases related to 2-nitropropane dioxygenase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Aldehyde:ferredoxin oxidoreductase:Na+/H+ antiporter:Type IV secretory pathway, VirD4 components:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Histidine metabolism:Lipopolysaccharide biosynthesis:Methane metabolism:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:hisD:gidB:sensory_box:gmhA:pabB:acr3:SUI1_rel:PEP_exosort:R_switched_Alx:Intracellular trafficking, secretion, and vesicular transport:Protein synthesis:Small molecule interactions:Regulatory functions:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Energy Metabolism:Transport and binding proteins:Carbohydrate Metabolism:Anions:Amino acid biosynthesis:Histidine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Translation factors:tRNA and rRNA base modification" 72 "Energy production and conversion:Ammonia permease:Glutamate synthase domain 1:Glutamate synthase domain 3:Glutamine synthetase:Nitrogen regulatory protein PII:Fe-S-cluster-containing hydrogenase components 1:Signal transduction histidine kinase:FKBP-type peptidyl-prolyl cis-trans isomerases 2:Uncharacterized conserved protein:Uncharacterized conserved protein:Zn-dependent proteases:Nitrogenase molybdenum-iron protein, alpha and beta chains:Transposase and inactivated derivatives:Response regulator with putative antiterminator output domain:Signal transduction histidine kinase, nitrogen specific:ABC-type molybdate transport system, permease component:Amino acid transport and metabolism:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Chloroalkane and chloroalkene degradation:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00159:sensory_box:GlnA:amt:nifK:modB_ABC:nifX:fdxN_nitrog:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Glutamate family:Amino acid biosynthesis:Conserved:Hypothetical proteins:Cations and iron carrying compounds:Anions:Transport and binding proteins:Small molecule interactions:Regulatory functions:Nitrogen fixation:Central intermediary metabolism:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Amino Acid Metabolism:Energy Metabolism" 73 "Energy production and conversion:DNA polymerase elongation subunit (family B):Peroxiredoxin:tRNA nucleotidyltransferase/poly(A) polymerase:Signal transduction histidine kinase:Ferredoxin:Metal-dependent amidase/aminoacylase/carboxypeptidase:Cytochrome c peroxidase:Uncharacterized conserved protein:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:RNA degradation:General function prediction only:Function unknown:Signal transduction mechanisms:amidohydrolases:pcnB:exo_TIGR04073:Cellular processes and signaling:Information storage and processing:Degradation of proteins, peptides, and glycopeptides:Protein fate:Genetic Information Processing:Folding Sorting and Degradation:Poorly characterized:Metabolism" 74 "Energy production and conversion:Ketol-acid reductoisomerase:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:ABC-type branched-chain amino acid transport systems, ATPase component:Ribosomal protein S1:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):ABC-type branched-chain amino acid transport systems, periplasmic component:Penicillin tolerance protein:Transcription elongation factor:dTDP-D-glucose 4,6-dehydratase:Lysine 2,3-aminomutase:Coenzyme F390 synthetase:Predicted enzyme related to lactoylglutathione lyase:ABC-type branched-chain amino acid transport system, permease component:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:ACT domain-containing protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Valine leucine and isoleucine biosynthesis:Lysine degradation:Phenylalanine metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Pantothenate and CoA biosynthesis:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Ribosome:RNA polymerase:General function prediction only:ispH_lytB:TIGR00238:ilvC:gyrA:dTDP_gluc_dehyt:sigma70-ECF:IOR_alpha:Metabolism:Poorly characterized:DNA metabolism:Electron transport:Energy metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism:Translation:Transcription:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:DNA replication, recombination, and repair:Amino Acid Metabolism:Amino acid biosynthesis:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling" 75 "Energy production and conversion:Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:Predicted EndoIII-related endonuclease:dGTP triphosphohydrolase:Ribosomal protein L35:ABC-type Co2+ transport system, permease component:Predicted integral membrane protein:Uncharacterized conserved protein:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Type II secretory pathway, component PulF:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Tfp pilus assembly protein, pilus retraction ATPase PilT:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell motility:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Purine metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Pyruvate metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Ribosome:Base excision repair:Function unknown:rpmI_bact:aroFGH:cbiM:TIGR00374:ilvE_II:lipoamide_DH:dGTP_triPase:pilT_fam:type_IV_pilB:Intracellular trafficking, secretion, and vesicular transport:Amino acid biosynthesis:Aromatic amino acid family:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism:Replication and Repair:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Carbohydrate Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Chemotaxis and motility:Hypothetical proteins:Conserved" 76 "Prephenate dehydratase:Cytidylate kinase:Uncharacterized conserved protein:Valyl-tRNA synthetase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase):ABC-type antimicrobial peptide transport system, ATPase component:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Precorrin-2 methylase:Lysophospholipase L1 and related esterases:Tfp pilus assembly protein PilN:Tfp pilus assembly protein PilO:Tfp pilus assembly protein PilP:Type II secretory pathway, component HofQ:Tfp pilus assembly protein, ATPase PilM:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell motility:Pyrimidine metabolism:Valine leucine and isoleucine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Porphyrin and chlorophyll metabolism:Limonene and pinene degradation:Aminoacyl-tRNA biosynthesis:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Function unknown:Signal transduction mechanisms:cmk:queA:TIGR00149_YbjQ:valS:pilM:cztR_silR_copR:cobI_cbiL:CM_P2:GSu_C4xC__C2xCH:IV_pilus_PilQ:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Information storage and processing:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Surface structures:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 77 "Energy production and conversion:Integral membrane protein possibly involved in chromosome condensation:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Leucyl-tRNA synthetase:Lipoprotein signal peptidase:Hypoxanthine-guanine phosphoribosyltransferase:Signal transduction histidine kinase:Chemotaxis protein histidine kinase and related kinases:FOG: CheY-like receiver:ABC-type antimicrobial peptide transport system, ATPase component:Ferredoxin:DNA polymerase III, delta subunit:Uncharacterized conserved protein:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Valine leucine and isoleucine biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Bacterial chemotaxis:DNA replication:Protein export:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:lspA:leuS_bact:crcB:holA:oligo_HPY:MJ0042_CXXC:exo_TIGR04073:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Poorly characterized:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Amino acids, peptides and amines:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 78 "Energy production and conversion:Glycosyltransferase:Zn-dependent protease with chaperone function:Na+-driven multidrug efflux pump:K+ transport systems, NAD-binding component:FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:BioD-like N-terminal domain of phosphotransacetylase:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Glycosyltransferases, probably involved in cell wall biogenesis:Uncharacterized conserved protein:Tfp pilus assembly protein, pilus retraction ATPase PilT:Coenzyme F420-reducing hydrogenase, alpha subunit:Signal transduction histidine kinase regulating citrate/malate metabolism:Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase):Amino acid transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Thiamine metabolism:Metabolic pathways:Two-component system:Bacterial chemotaxis:Sulfur relay system:General function prediction only:Function unknown:Signal transduction mechanisms:matE:pilT_fam:cytochr_NrfH:HpnI:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Poorly characterized:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Electron transport:Transport and binding proteins:Other:Cellular processes:Chemotaxis and motility:Cellular processes and signaling:Metabolism:Metabolism" 79 "Translation initiation factor 1 (eIF-1/SUI1) and related proteins:Dihydrofolate reductase:1,4-alpha-glucan branching enzyme:Periplasmic serine proteases (ClpP class):Predicted permease:Signal transduction histidine kinase:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Membrane protein TerC, possibly involved in tellurium resistance:Nicotinic acid phosphoribosyltransferase:Homocysteine/selenocysteine methylase (S-methylmethionine-dependent):FOG: GAF domain:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Uncharacterized conserved protein:Maltooligosyl trehalose synthase:Signal transduction histidine kinase regulating citrate/malate metabolism:Predicted transcriptional regulator:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:SppA_dom:SUI1_rel:NAPRTase_put:trehalose_TreY:trehalose_TreZ:R_switched_Alx:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Regulatory functions:Small molecule interactions:Protein synthesis:Translation factors:Protein fate:Degradation of proteins, peptides, and glycopeptides:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 80 "Energy production and conversion:Aspartate oxidase:Tryptophanyl-tRNA synthetase:Fructose/tagatose bisphosphate aldolase:Diaminopimelate epimerase:ABC-type branched-chain amino acid transport systems, ATPase component:ATPase components of ABC transporters with duplicated ATPase domains:Thioredoxin reductase:Anthranilate phosphoribosyltransferase:Branched-chain amino acid ABC-type transport system, permease components:Transcription termination factor:Fe-S oxidoreductase:Predicted dioxygenase:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Predicted HD-superfamily hydrolase:Short-chain alcohol dehydrogenase of unknown specificity:Flp pilus assembly protein TadD, contains TPR repeats:Alpha-tubulin suppressor and related RCC1 domain-containing proteins:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Lysine biosynthesis:Tryptophan metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Nicotinate and nicotinamide metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:trpS:HDIG:nadB:DapF:trpD:TRX_reduct:nusB:HpnJ:ABC_ABC_ChvD:Intracellular trafficking, secretion, and vesicular transport:Cytoskeleton:Metabolism:Global:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Protein synthesis:Nucleotide Metabolism:tRNA aminoacylation:Amino acid biosynthesis:Aromatic amino acid family:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Transcription factors:Transcription:Electron transport:Energy metabolism:Metabolism" 81 "Prephenate dehydratase:1-acyl-sn-glycerol-3-phosphate acyltransferase:Prephenate dehydrogenase:Phosphoribosylpyrophosphate synthetase:Superfamily II DNA and RNA helicases:CDP-diglyceride synthetase:Cytosine/adenosine deaminases:Fe2+/Zn2+ uptake regulation proteins:Predicted sugar phosphate isomerase involved in capsule formation:Actin-like ATPase involved in cell morphogenesis:Metal-dependent hydrolases of the beta-lactamase superfamily I:Transcriptional regulator:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Tfp pilus assembly protein, ATPase PilM:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Pentose phosphate pathway:Purine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Glycerolipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:General function prediction only:Signal transduction mechanisms:kpsF:AGP_acyltrn:mreB:pilM:ribP_PPkin:phd_fam:CM_P2:Intracellular trafficking, secretion, and vesicular transport:Amino acid biosynthesis:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Folding Sorting and Degradation:Global:Metabolism:Energy metabolism:Sugars:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Mobile and extrachromosomal element functions:Other:Metabolism:Aromatic amino acid family:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 82 "Energy production and conversion:Protein chain release factor A:ABC-type phosphate transport system, permease component:Ni,Fe-hydrogenase maturation factor:FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:ABC-type antimicrobial peptide transport system, ATPase component:Transcriptional regulator:Flagellar biosynthesis pathway, component FlhB:Outer membrane protein:Arabinose efflux permease:Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component:Signal transduction histidine kinase regulating citrate/malate metabolism:Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase:Type III secretory pathway, component EscT:Signal transduction histidine kinase:Predicted secreted hydrolase:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Nitrogen metabolism:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:prfA:hydrog_prot:sensory_box:flhB:efflux_Bcr_CflA:3a0107s02c:fliR:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Cellular processes:Anions:Transport and binding proteins:Translation factors:Protein synthesis:Small molecule interactions:Regulatory functions:Metabolism:Cell Motility:Cellular Processes:Signal Transduction:Membrane Transport:Environmental Information Processing:Energy Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Chemotaxis and motility" 83 "Phenylalanyl-tRNA synthetase alpha subunit:Predicted Co/Zn/Cd cation transporters:Shikimate 5-dehydrogenase:Cysteinyl-tRNA synthetase:Predicted redox protein, regulator of disulfide bond formation:DNA polymerase sliding clamp subunit (PCNA homolog):Prolipoprotein diacylglyceryltransferase:Uncharacterized protein conserved in bacteria:Restriction endonuclease:Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain):Type II secretory pathway, pseudopilin PulG:Membrane-bound metallopeptidase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Bacterial secretion system:Mismatch repair:Homologous recombination:Function unknown:DNA_YbaB_EbfC:CoA_E_activ:cysS:pheS:aroE:lgt:dnan:CDF:IV_pilin_GFxxxE:selenium_YedF:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Information storage and processing:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Protein modification and repair:Transport and binding proteins:Cations and iron carrying compounds:Unknown function:General:Amino acid biosynthesis:Aromatic amino acid family:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 84 "Glutamyl- and glutaminyl-tRNA synthetases:Transketolase:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase:Predicted unusual protein kinase:Membrane carboxypeptidase (penicillin-binding protein):D-Tyr-tRNAtyr deacylase:FOG: GGDEF domain:FOG: GAF domain:Uridine phosphorylase:Rhodanese-related sulfurtransferase:Uncharacterized protein conserved in bacteria:Transposase and inactivated derivatives:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose phosphate pathway:Ubiquinone and other terpenoid-quinone biosynthesis:Pyrimidine metabolism:Lipopolysaccharide biosynthesis:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:ispF:tktlase_bact:GGDEF:TIGR00256:glnS:PBP_1a_fam:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Global:Metabolism:Energy metabolism:Pentose phosphate pathway:Protein synthesis:tRNA aminoacylation:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Signal transduction:Other:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 85 "Energy production and conversion:Predicted metal-dependent phosphoesterases (PHP family):Signal transduction histidine kinase:Aspartate ammonia-lyase:Flagellar motor protein:Ferritin-like protein:Uncharacterized conserved protein:Desulfoferrodoxin:Uncharacterized protein involved in outer membrane biogenesis:Signal transduction histidine kinase:Uncharacterized conserved small protein:Amino acid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Metabolic pathways:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:Poorly characterized:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:Small molecule interactions:Cellular processes and signaling:Metabolism:Metabolism" 86 "Predicted Zn-dependent proteases and their inactivated homologs:Transcriptional regulator:FOG: CheY-like receiver:Membrane-fusion protein:ABC-type multidrug transport system, ATPase and permease components:Transcriptional regulator:Transcriptional regulator:Outer membrane protein:Uncharacterized protein conserved in bacteria:Predicted enzyme related to lactoylglutathione lyase:Uncharacterized protein conserved in bacteria:Gas vesicle protein:Transcription:Cell wall/membrane/envelope biogenesis:General function prediction only:Function unknown:Signal transduction mechanisms:RND_mfp:outer_NodT:PEP_exosort:VI_zyme:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Surface structures:Cell envelope:Porins:Unknown substrate:Transport and binding proteins:Information storage and processing:Cellular processes and signaling:Poorly characterized" 87 "ATP-dependent Lon protease, bacterial type:Sugar kinases, ribokinase family:Predicted xylanase/chitin deacetylase:Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake:Predicted endonuclease distantly related to archaeal Holliday junction resolvase:RimM protein, required for 16S rRNA processing:FOG: PAS/PAC domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Two-component system:Protein export:Bacterial secretion system:Signal transduction mechanisms:sensory_box:TIGR00252:dprA:lon:tatAE:16S_RimM:Intracellular trafficking, secretion, and vesicular transport:Hypothetical proteins:Conserved:Information storage and processing:Cellular processes and signaling:Metabolism:Protein fate:RNA processing:Transcription:Small molecule interactions:Regulatory functions:Genetic Information Processing:Signal Transduction:Membrane Transport:Environmental Information Processing:Protein and peptide secretion and trafficking:Folding Sorting and Degradation:Degradation of proteins, peptides, and glycopeptides:Cellular processes:DNA transformation" 88 "Glucan phosphorylase:AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful):7-keto-8-aminopelargonate synthetase and related enzymes:Tryptophan synthase alpha chain:6-phosphofructokinase:Predicted Zn-dependent proteases and their inactivated homologs:Ketopantoate hydroxymethyltransferase:Uncharacterized conserved protein:Acetolactate synthase, small (regulatory) subunit:Glycosyltransferases involved in cell wall biogenesis:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Periplasmic serine proteases (ClpP class):ABC-type transport system involved in resistance to organic solvents, ATPase component:N-acetylglutamate synthase and related acetyltransferases:Uncharacterized conserved protein:Predicted signal transduction protein:Cytotoxic translational repressor of toxin-antitoxin stability system:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Methylase involved in ubiquinone/menaquinone biosynthesis:ATPase related to the helicase subunit of the Holliday junction resolvase:Hemerythrin:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Galactose metabolism:Purine metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Starch and sucrose metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:One carbon pool by folate:Methane metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:acolac_sm:TIGR00149_YbjQ:panB:GGDEF:trpA:HDIG:purH:SppA_dom:bioF:BioC:P_ylase:RelE_StbE:hemeryth_dom:PFKA_ATP:mob_myst_A:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis and degradation of polysaccharides:Glycolysis/gluconeogenesis:Energy metabolism:Metabolism:Metabolism:Global:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Other:Carbohydrate Metabolism:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Aromatic amino acid family:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Pantothenate and coenzyme A:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Mobile and extrachromosomal element functions:Degradation of proteins, peptides, and glycopeptides:Protein fate:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides" 89 "Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Mg-dependent DNase:Phosphate/sulphate permeases:ABC-type Co2+ transport system, permease component:Queuine/archaeosine tRNA-ribosyltransferase:Ribonuclease D:ABC-type cobalt transport system, permease component CbiQ and related transporters:Signal transduction histidine kinase:Endonuclease IV:ABC-type transport system involved in cytochrome c biogenesis, permease component:Parvulin-like peptidyl-prolyl isomerase:Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1:Amidases related to nicotinamidase:Phosphate transport regulator (distant homolog of PhoU):Cobyric acid synthase:Uroporphyrinogen-III synthase:Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase:Cobalamin biosynthesis protein CbiD:Uncharacterized bacitracin resistance protein:DNA repair proteins:Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Predicted flavin-nucleotide-binding protein:Signal transduction histidine kinase, nitrogen specific:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Peptidoglycan biosynthesis:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Two-component system:Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:TIGR00010:cbiM:sensory_box:cbiD:cobQ:Q_tRNA_tgt:nfo:radc:undec_PP_bacA:L_thr_O3P_dcar:cobA_cysG_Cterm:CbiQ_TIGR:cytochr_II_ccsB:Defense mechanisms:Cations and iron carrying compounds:Transport and binding proteins:Protein modification and repair:Protein fate:tRNA and rRNA base modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Small molecule interactions:Regulatory functions:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Cellular processes and signaling:Glycan Biosynthesis and Metabolism:Metabolism:Poorly characterized:Information storage and processing:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function" 90 "Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Glycosyltransferase:ATPases involved in chromosome partitioning:Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily:CMP-N-acetylneuraminic acid synthetase:dTDP-D-glucose 4,6-dehydratase:Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Glycosyltransferases, probably involved in cell wall biogenesis:Sialic acid synthase:Uncharacterized conserved protein:Uncharacterized protein involved in exopolysaccharide biosynthesis:Type II secretory pathway, component ExeA (predicted ATPase):Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:General function prediction only:Function unknown:eps_fam:8TM_EpsH:EpsI_fam:pepcterm_polyde:pepcterm_ChnLen:pepcterm_ATPase:pepcterm_hypo_1:NeuD_NnaD:Intracellular trafficking, secretion, and vesicular transport:Cell envelope:Carbohydrates, organic alcohols, and acids:Unknown substrate:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Metabolism:Metabolism:Global:Poorly characterized:Carbohydrate Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides" 91 "Energy production and conversion:Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog):Delta-aminolevulinic acid dehydratase:Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases:Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family:Leucyl aminopeptidase:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Malic enzyme:Carbonic anhydrase:Biotin carboxyl carrier protein:Universal stress protein UspA and related nucleotide-binding proteins:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Preprotein translocase subunit SecA (ATPase, RNA helicase):ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:N-acetylglutamate synthase (N-acetylornithine aminotransferase):O-acetylhomoserine sulfhydrylase:Predicted N-acetylglucosaminyl transferase:ABC-type uncharacterized transport system, periplasmic component:Predicted lipoprotein involved in nitrous oxide reduction:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Cysteine and methionine metabolism:Arginine and proline metabolism:Glutathione metabolism:Pyruvate metabolism:Propanoate metabolism:Porphyrin and chlorophyll metabolism:Nitrogen metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:ArgJ:gatA:gatB:salvage_mtnA:BCCP:secA:purE:OAH_OAS_sulfhy:paired_CXXCH_1:degP_htrA_DO:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Amino acid biosynthesis:Aspartate family:Glutamate family:Serine family:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 92 "Energy production and conversion:Rhodanese-related sulfurtransferase:FOG: HEAT repeat:Outer membrane protein:Exonuclease VII, large subunit:Predicted membrane protein:Flagellar biosynthesis pathway, component FliQ:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:AraC-type DNA-binding domain-containing proteins:Retron-type reverse transcriptase:Transposase and inactivated derivatives:Transposase and inactivated derivatives:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Flagellar assembly:Mismatch repair:Function unknown:Signal transduction mechanisms:xseA:TIGR00341:fliQ:Intracellular trafficking, secretion, and vesicular transport:Cellular Processes:Hypothetical proteins:Replication and Repair:Conserved:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Genetic Information Processing:Chemotaxis and motility:Cellular processes:Degradation of DNA:DNA metabolism:Cell Motility" 93 "Glycogen synthase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:(acyl-carrier-protein) S-malonyltransferase:Cystathionine beta-lyases/cystathionine gamma-synthases:Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB):Outer membrane receptor proteins, mostly Fe transport:Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB:Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain):Homoserine acetyltransferase:Type II secretory pathway, pseudopilin PulG:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Cell motility:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Selenocompound metabolism:Starch and sucrose metabolism:Nitrogen metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:fabD:sensory_box:CoA_E_activ:homoserO_Ac_trn:trpB_rel:typeII_sec_gspG:glgA:Intracellular trafficking, secretion, and vesicular transport:Amino acid biosynthesis:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:Cellular processes:Pathogenesis:Unknown function:Enzymes of unknown specificity:Metabolism:Aspartate family:Cellular processes and signaling:Metabolism:Poorly characterized" 94 "Hydrogenase maturation factor:Hydrogenase maturation factor:Signal transduction histidine kinase:Multimeric flavodoxin WrbA:UDP-N-acetylmuramate-alanine ligase:FOG: CheY-like receiver:UDP-N-acetylmuramate dehydrogenase:Predicted helicases:DNA polymerase III, delta subunit:Multisubunit Na+/H+ antiporter, MnhF subunit:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:D-Glutamine and D-glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Metabolic pathways:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Signal transduction mechanisms:hypF:murB:murC:holA:cas3_core:C_GCAxxG_C_C:MJ0042_CXXC:hypE:Biosynthesis and degradation of murein sacculus and peptidoglycan:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Replication and Repair:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein modification and repair:Mobile and extrachromosomal element functions:Other:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 95 "Energy production and conversion:Glycosyltransferases involved in cell wall biogenesis:Transcriptional regulator:UDP-N-acetylmuramoylalanine-D-glutamate ligase:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:ABC-type transport system involved in resistance to organic solvents, periplasmic component:Triphosphoribosyl-dephospho-CoA synthetase:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Flagellar basal body L-ring protein:Membrane transporters of cations and cationic drugs:Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases:Predicted ATPase (AAA+ superfamily):Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:D-Glutamine and D-glutamate metabolism:Peptidoglycan biosynthesis:Metabolic pathways:Two-component system:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:murD:Poorly characterized:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 96 "Energy production and conversion:Zn-dependent hydrolases, including glyoxylases:ATPases with chaperone activity, ATP-binding subunit:Signal transduction histidine kinase:Phosphate uptake regulator:ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Methyl-accepting chemotaxis protein:ABC-type Mn2+/Zn2+ transport systems, permease components:Deoxyxylulose-5-phosphate synthase:Ribonucleases G and E:Ni,Fe-hydrogenase I small subunit:K+-transporting ATPase, A chain:High-affinity K+ transport system, ATPase chain B:Predicted permeases:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:ABC transporters:Two-component system:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:hydA:kdpA:RNaseEG:ATPase_P-type:phoU_full:VI_ClpV1:VI_chp_1:VI_chp_6:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Pathogenesis:Cellular processes:Cations and iron carrying compounds:Anions:Transport and binding proteins:Degradation of RNA:Transcription:Small molecule interactions:Regulatory functions:Electron transport:Energy metabolism:Environmental Information Processing:Signal Transduction:Membrane Transport" 97 "Energy production and conversion:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:Predicted xylanase/chitin deacetylase:Aconitase A:Uncharacterized low-complexity proteins:K+-transporting ATPase, c chain:FOG: PAS/PAC domain:Uncharacterized protein conserved in bacteria:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Uncharacterized conserved protein:Uncharacterized integral membrane protein:Carbohydrate transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Glyoxylate and dicarboxylate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Function unknown:Signal transduction mechanisms:sensory_box:kdpC:aconitase_1:GSu_C4xC__C2xCH:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:TCA cycle:Regulatory functions:Small molecule interactions:Transport and binding proteins:Cations and iron carrying compounds:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 98 "3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:3,4-dihydroxy-2-butanone 4-phosphate synthase:Folate-dependent phosphoribosylglycinamide formyltransferase PurN:3-dehydroquinate synthetase:Biotin-(acetyl-CoA carboxylase) ligase:Enoyl-[acyl-carrier-protein] reductase (NADH):Predicted phosphatase/phosphohexomutase:Glycyl-tRNA synthetase, alpha subunit:Organic solvent tolerance protein OstA:Periplasmic protein involved in polysaccharide export:Low specificity phosphatase (HAD superfamily):NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain:Signal transduction histidine kinase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Purine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Starch and sucrose metabolism:Lipopolysaccharide biosynthesis:One carbon pool by folate:Riboflavin metabolism:Biotin metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Signal transduction mechanisms:birA_ligase:sensory_box:HDIG:glyQ:ribA:PurN:aroB:HAD-SF-IA-v3:YrbI-phosphatas:Cell envelope:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA aminoacylation:Protein fate:Protein modification and repair:Unknown function:Enzymes of unknown specificity:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 99 "Energy production and conversion:3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:Imidazoleglycerol-phosphate synthase:2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway):Peptide methionine sulfoxide reductase:Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Thioredoxin reductase:Zn-dependent protease with chaperone function:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:Predicted Zn-dependent peptidases:Predicted permease:Collagenase and related proteases:ABC-type multidrug transport system, permease component:Predicted Fe-S oxidoreductase:Predicted branched-chain amino acid permease (azaleucine resistance):Transcriptional regulator:Ribonucleases G and E:Heme/copper-type cytochrome/quinol oxidases, subunit 2:Cytochrome c peroxidase:Carbon starvation protein, predicted membrane protein:Uncharacterized enzyme of thiazole biosynthesis:Sulfur transfer protein involved in thiamine biosynthesis:Predicted periplasmic solute-binding protein:Signal transduction histidine kinase, nitrogen specific:Predicted membrane protein:ABC-type tungstate transport system, periplasmic component:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Oxidative phosphorylation:Histidine metabolism:Thiamine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:RNA degradation:Sulfur relay system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:HMP-P_kinase:TIGR00148:msrA:hisF:RNaseEG:TIGR01212:thiS:CoxB:Na_symport_sm:Defense mechanisms:General:Enzymes of unknown specificity:Unknown function:Adaptations to atypical conditions:Cellular processes:Unknown substrate:Transport and binding proteins:Degradation of RNA:Transcription:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Poorly characterized:Energy Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Thiamine:Biosynthesis of cofactors, prosthetic groups, and carriers:Histidine family:Amino acid biosynthesis" 100 "Energy production and conversion:Succinyl-CoA synthetase, alpha subunit:Polyferredoxin:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Fe-S oxidoreductase:Phosphomannomutase:Alpha-amylase/alpha-mannosidase:Chemotaxis protein CheC, inhibitor of MCP methylation:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase regulating citrate/malate metabolism:Signal transduction histidine kinase, nitrogen specific:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Cell motility:Citrate cycle (TCA cycle):Fructose and mannose metabolism:Alanine aspartate and glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Propanoate metabolism:C5-Branched dibasic acid metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:sucCoAalpha:gltA:sam_1_link_chp:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:TCA cycle:Regulatory functions:Small molecule interactions:Amino acid biosynthesis:Glutamate family:Cellular processes and signaling:Metabolism:Metabolism" 101 "Energy production and conversion:Malate/lactate dehydrogenases:3-isopropylmalate dehydratase small subunit:Acetate kinase:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Citrate synthase:Fructose-2,6-bisphosphatase:Thiamine biosynthesis protein ThiC:Threonyl-tRNA synthetase:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:FOG: CheY-like receiver:Aconitase B:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Uracil-DNA glycosylase:Uncharacterized conserved protein:Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain:NaMN:DMB phosphoribosyltransferase:Monomeric isocitrate dehydrogenase:Uncharacterized anaerobic dehydrogenase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Citrate cycle (TCA cycle):Oxidative phosphorylation:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Taurine and hypotaurine metabolism:Glutathione metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Thiamine metabolism:Riboflavin metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:ackA:acnB:monomer_idh:thiC:TIGR00251:thrS:dapA:ttdA_fumA_fumB:UDG_fam4:MalateDH_bact:sdhA_Bsu:sdhC_b558_fam:cobT_DBIPRT:ribazole_cobC:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:Aspartate family:Amino acid biosynthesis:Conserved:Hypothetical proteins:tRNA aminoacylation:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:TCA cycle:Fermentation:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Energy Metabolism:Thiamine:Carbohydrate Metabolism" 102 "Putative translation initiation inhibitor, yjgF family:Guanosine polyphosphate pyrophosphohydrolases/synthetases:Sugar kinases, ribokinase family:DNA polymerase sliding clamp subunit (PCNA homolog):ATPase involved in DNA replication initiation:Predicted membrane-associated Zn-dependent proteases 1:Phosphomannomutase:Phosphatidylserine synthase:Cold shock proteins:Uncharacterized protein conserved in bacteria:Protein-L-isoaspartate carboxylmethyltransferase:Septum formation initiator:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Metabolic pathways:DNA replication:Mismatch repair:Homologous recombination:Function unknown:Signal transduction mechanisms:TIGR00004:TIGR00054:pimt:TIGR00282:DnaA:pssA:dnan:spoT_relA:glmM:Information storage and processing:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Replication and Repair:Global:Metabolism:Central intermediary metabolism:Amino sugars:Fatty acid and phospholipid metabolism:Biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Protein fate:Degradation of proteins, peptides, and glycopeptides:Protein modification and repair:Cellular processes:Adaptations to atypical conditions:Unknown function:Enzymes of unknown specificity:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 103 "4-hydroxybenzoate polyprenyltransferase and related prenyltransferases:Signal transduction histidine kinase:ABC-type polar amino acid transport system, ATPase component:ABC-type multidrug transport system, ATPase component:ABC-type polysaccharide/polyol phosphate transport system, ATPase component:Oligoendopeptidase F:Predicted glycosyltransferases:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:ABC-type polysaccharide/polyol phosphate export systems, permease component:ABC-type uncharacterized transport system, periplasmic component:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:PAP2 (acid phosphatase) superfamily protein:ABC-type anion transport system, duplicated permease component:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:ABC transporters:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:vgr_GE:M3_fam_3:CxxC_CxxC_SSSS:IV_VI_DotU:VI_chp_2:VI_chp_5:Defense mechanisms:Regulatory functions:Membrane Transport:Environmental Information Processing:Poorly characterized:Metabolism:Cellular processes and signaling:Pathogenesis:Cellular processes:Small molecule interactions:DNA interactions" 104 "Aspartyl/asparaginyl-tRNA synthetases:Molecular chaperone (small heat shock protein):Anthranilate/para-aminobenzoate synthases component I:3-oxoacyl-(acyl-carrier-protein) synthase:ATP-dependent Lon protease, bacterial type:ATPase components of ABC transporters with duplicated ATPase domains:Small-conductance mechanosensitive channel:ABC-type branched-chain amino acid transport systems, periplasmic component:Permeases of the drug/metabolite transporter (DMT) superfamily:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Transcriptional regulator:Methylase of chemotaxis methyl-accepting proteins:Chemotaxis protein; stimulates methylation of MCP proteins:Site-specific recombinases, DNA invertase Pin homologs:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Serine phosphatase RsbU, regulator of sigma subunit:ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain:Uncharacterized conserved protein:Outer membrane lipoprotein-sorting protein:Uncharacterized conserved protein:Alpha-tubulin suppressor and related RCC1 domain-containing proteins:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Folate biosynthesis:Aminoacyl-tRNA biosynthesis:ABC transporters:Two-component system:Bacterial chemotaxis:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:asnS:pabB:lon:Defense mechanisms:Cytoskeleton:Signal Transduction:Membrane Transport:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Metabolism:Folic acid:Biosynthesis of cofactors, prosthetic groups, and carriers:Degradation of proteins, peptides, and glycopeptides:Protein fate:tRNA aminoacylation:Protein synthesis:Cell Motility:Cellular Processes" 105 "4-hydroxybenzoate polyprenyltransferase and related prenyltransferases:Glycosyltransferases involved in cell wall biogenesis:Signal transduction histidine kinase:ADP-heptose:LPS heptosyltransferase:ABC-type polysaccharide/polyol phosphate transport system, ATPase component:Coenzyme F390 synthetase:ABC-type polysaccharide/polyol phosphate export systems, permease component:DNA-binding HTH domain-containing proteins:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:ABC transporters:Function unknown:Signal transduction mechanisms:vgr_GE:casC_Cse4:casE_Cse3:casA_cse1:Environmental Information Processing:Membrane Transport:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Mobile and extrachromosomal element functions" 106 "Chromatin structure and dynamics:Deacetylases, including yeast histone deacetylase and acetoin utilization protein:Thymidylate kinase:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:Lactoylglutathione lyase and related lyases:NAD/FAD-utilizing enzyme apparently involved in cell division:Signal transduction histidine kinase:Phosphatidylserine decarboxylase:Transcription elongation factor:ADP-ribose pyrophosphatase:DNA uptake protein and related DNA-binding proteins:Restriction endonuclease:ABC-type uncharacterized transport system, periplasmic component:Predicted O-linked N-acetylglucosamine transferase, SPINDLY family:Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta):Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Glycerophospholipid metabolism:Pyruvate metabolism:One carbon pool by folate:Carbon fixation pathways in prokaryotes:Metabolic pathways:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:gidA:PS_decarb_rel:sensory_box:greB:metmalonyl_epim:Defense mechanisms:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Regulatory functions:Small molecule interactions:Transcription:Transcription factors:Protein synthesis:tRNA and rRNA base modification:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 107 "Energy production and conversion:N-formylmethionyl-tRNA deformylase:tRNA-(guanine-N1)-methyltransferase:Polyferredoxin:4-hydroxybenzoate polyprenyltransferase and related prenyltransferases:Nucleoside-diphosphate-sugar epimerases:Signal recognition particle GTPase:Acetylglutamate kinase:ABC-type multidrug transport system, permease component:Deoxyxylulose-5-phosphate synthase:Rad3-related DNA helicases:FOG: HEAT repeat:Squalene cyclase:Predicted membrane protein:NADH:flavin oxidoreductases, Old Yellow Enzyme family:Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Predicted transcriptional regulator:Signal transduction histidine kinase:Ornithine/acetylornithine aminotransferase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:pept_deformyl:trmD:dxs:sensory_box:TIGR00341:argD:argB:ffh:ubiA_other:hopene_cyclase:HpnA:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Protein modification and repair:Protein and peptide secretion and trafficking:Protein fate:tRNA and rRNA base modification:Protein synthesis:Small molecule interactions:Regulatory functions:Other:Fatty acid and phospholipid metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Biosynthesis of cofactors, prosthetic groups, and carriers:Amino Acid Metabolism:Menaquinone and ubiquinone:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Glutamate family:Amino acid biosynthesis:Conserved:Hypothetical proteins" 108 "Histidinol phosphatase and related phosphatases:Phosphoheptose isomerase:Zn-dependent protease with chaperone function:ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase:Gas vesicle protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Lipopolysaccharide biosynthesis:Metabolic pathways:General function prediction only:cyt_tran_rel:GmhB_yaeD:gmhA:Metabolism:Glycan Biosynthesis and Metabolism:Global:Metabolism:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Poorly characterized" 109 "Energy production and conversion:Predicted permeases:ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components:FOG: TPR repeat, SEL1 subfamily:Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit:ABC-type Mn/Zn transport systems, ATPase component:Flagellar biosynthesis pathway, component FliP:Uncharacterized Fe-S protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation):Surface lipoprotein:ABC-type taurine transport system, periplasmic component:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Valine leucine and isoleucine biosynthesis:Pyruvate metabolism:Butanoate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Flagellar assembly:General function prediction only:Signal transduction mechanisms:molyb_syn:fliP:paired_CXXCH_1:flagell_FliJ:PDH_E1_alph_x:Intracellular trafficking, secretion, and vesicular transport:Pyruvate dehydrogenase:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Membrane Transport:Environmental Information Processing:Amino Acid Metabolism:Metabolism:Carbohydrate Metabolism:Poorly characterized:Cellular processes and signaling:Chemotaxis and motility:Cellular processes" 110 "Energy production and conversion:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Di- and tricarboxylate transporters:Signal transduction histidine kinase:Predicted unusual protein kinase:Nitroreductase:Outer membrane protein:Uncharacterized conserved protein:Uncharacterized protein, possibly involved in motility:Predicted membrane protein:Putative virion core protein (lumpy skin disease virus):Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Fatty acid metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Glycerophospholipid metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Metabolism:Global:Metabolism of Cofactors and Vitamins:Lipid Metabolism" 111 "Energy production and conversion:Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases:Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family:Leucyl aminopeptidase:Malic enzyme:Carbonic anhydrase:Universal stress protein UspA and related nucleotide-binding proteins:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Predicted hydrolase (HAD superfamily):ABC-type polar amino acid transport system, ATPase component:Glutamine synthetase adenylyltransferase:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Predicted N-acetylglucosaminyl transferase:Predicted enzyme related to lactoylglutathione lyase:Predicted lipoprotein involved in nitrous oxide reduction:Uncharacterized protein conserved in bacteria:Flp pilus assembly protein TadD, contains TPR repeats:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Glutathione metabolism:Pyruvate metabolism:Nitrogen metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:gatA:salvage_mtnA:purE:tol_pal_ybgF:Pal_lipo:DivI1A_domain:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Translation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:tRNA aminoacylation:Amino acid biosynthesis:Aspartate family:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 112 "Energy production and conversion:tRNA-dihydrouridine synthase:ATP-dependent Zn proteases:NTP pyrophosphohydrolases including oxidative damage repair enzymes:Predicted hydrolase of the metallo-beta-lactamase superfamily:Predicted PP-loop superfamily ATPase:Mannose-6-phosphate isomerase:Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:dTDP-glucose pyrophosphorylase:Cobalamin biosynthesis protein CobD/CbiB:Putative threonine efflux protein:Transcriptional regulator:Predicted DNA-binding proteins:Uncharacterized conserved protein:NADH:ubiquinone oxidoreductase 24 kD subunit:Glycine cleavage system regulatory protein:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Fructose and mannose metabolism:Oxidative phosphorylation:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:RNA degradation:General function prediction only:Function unknown:Signal transduction mechanisms:gatC:TIGR00364:cobD:MG423:nifR3_yhdG:rmlA:FtsH_fam:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Unknown function:Conserved:Hypothetical proteins:Degradation of proteins, peptides, and glycopeptides:Protein fate:tRNA aminoacylation:Protein synthesis:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Translation:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Energy Metabolism:Carbohydrate Metabolism" 113 "Energy production and conversion:Anaerobic dehydrogenases, typically selenocysteine-containing:Ribosomal protein L31:Nitrogen regulatory protein PII:Mannose-6-phosphate isomerase:Membrane-fusion protein:Fe-S-cluster-containing hydrogenase components 2:Pyruvate-formate lyase-activating enzyme:Exonuclease VII small subunit:Uncharacterized protein conserved in bacteria:Putative silver efflux pump:Uncharacterized protein conserved in bacteria:Predicted transcriptional regulator:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Ribosome:Mismatch repair:Function unknown:Signal transduction mechanisms:L31:sensory_box:2A0601:xseB:TAT_signal_seq:RND_mfp:sigma70-ECF:Poorly characterized:Degradation of DNA:DNA metabolism:Small molecule interactions:Regulatory functions:Metabolism:Global:Signal Transduction:Environmental Information Processing:Replication and Repair:Metabolism:Translation:Genetic Information Processing:Energy Metabolism:Protein synthesis:Carbohydrate Metabolism:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Unknown substrate:Cations and iron carrying compounds:Information storage and processing:Cellular processes and signaling:Metabolism" 114 "Energy production and conversion:Glutamate synthase domain 2:3-oxoacyl-(acyl-carrier-protein) synthase:Pyrroline-5-carboxylate reductase:Ni,Fe-hydrogenase I large subunit:Fe-S-cluster-containing hydrogenase components 1:Uncharacterized NAD(FAD)-dependent dehydrogenases:Signal transduction histidine kinase:Ni,Fe-hydrogenase maturation factor:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Ni,Fe-hydrogenase I small subunit:Sec-independent protein secretion pathway components:Uncharacterized distant relative of homeotic protein bithoraxoid:Electron transfer flavoprotein, beta subunit:FOG: GGDEF domain:ABC-type tungstate transport system, permease component:DNA uptake lipoprotein:Polysulphide reductase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Fatty acid biosynthesis:Arginine and proline metabolism:Nitrotoluene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Flagellar assembly:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:hydrog_prot:proC:sensory_box:hydA:TAT_signal_seq:tatAE:OM_YfiO:FlgM_jcvi:Intracellular trafficking, secretion, and vesicular transport:Protein and peptide secretion and trafficking:Protein fate:Small molecule interactions:Regulatory functions:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Xenobiotics Biodegradation and Metabolism:Amino Acid Metabolism:Cellular processes and signaling:Lipid Metabolism:Metabolism:Poorly characterized:Glutamate family:Amino acid biosynthesis" 115 "Multimeric flavodoxin WrbA:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Putative NADPH-quinone reductase (modulator of drug activity B):Transcription:Two-component system:General function prediction only:Signal transduction mechanisms:Information storage and processing:Cellular processes and signaling:Signal Transduction:Poorly characterized:Environmental Information Processing" 116 "Energy production and conversion:Ribosomal protein L11:Ribosomal protein S11:Seryl-tRNA synthetase:Preprotein translocase subunit SecY:Ribosomal protein L17:Ribosomal protein S18:Ribosomal protein L20:Threonyl-tRNA synthetase:Translation elongation factors (GTPases):Predicted Fe-S oxidoreductases:F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K:Uncharacterized conserved protein:Bacterial nucleoid DNA-binding protein:Cold shock proteins:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Predicted membrane protein:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Oxidative phosphorylation:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Ribosome:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:L17:S18:small_GTP:TIGR00278:serS:thrS:3a0501s007:rplT_bact:ATP_synt_c:L11_bact:bact_S11:rSAM_more_4Fe4S:Intracellular trafficking, secretion, and vesicular transport:tRNA aminoacylation:Protein synthesis:ATP-proton motive force interconversion:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Translation:Genetic Information Processing:Ribosomal proteins: synthesis and modification:Energy Metabolism:Protein fate:Protein and peptide secretion and trafficking:Hypothetical proteins:Conserved:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 117 "Carbonic anhydrase:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:ABC-type polar amino acid transport system, ATPase component:Subtilisin-like serine proteases:Hemolysin-coregulated protein (uncharacterized):FOG: PKD repeat:Phage tail sheath protein FI:Phage baseplate assembly protein W:Competence protein ComGC:Amino acid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Nitrogen metabolism:ABC transporters:Two-component system:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:GSu_C4xC__C2xCH:IV_pilin_GFxxxE:VI_effect_Hcp1:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Energy Metabolism:Environmental Information Processing:Membrane Transport:Signal Transduction:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Pathogenesis:Cellular processes and signaling:Metabolism:Metabolism" 118 "Energy production and conversion:Glycosyltransferases involved in cell wall biogenesis:Di- and tricarboxylate transporters:Transcriptional regulator:Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Signal transduction histidine kinase:Fe-S oxidoreductase:Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA:Predicted membrane protein:Transcriptional regulator:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Transcriptional regulators:Cyclopropane fatty acid synthase and related methyltransferases:NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding:Uridine phosphorylase:Methylase of polypeptide chain release factors:Bacterial lipocalin:Uncharacterized conserved protein:Predicted symporter:Predicted membrane protein:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pyrimidine metabolism:Nicotinate and nicotinamide metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Function unknown:Signal transduction mechanisms:molyb_syn:hemK_fam:hemN_rel:yihY_not_rbn:Na_symport_lg:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Unknown function:Protein modification and repair:Protein fate:Metabolism:Global:Metabolism of Cofactors and Vitamins:Metabolism:Nucleotide Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing" 119 "Energy production and conversion:Ornithine carbamoyltransferase:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:(acyl-carrier-protein) S-malonyltransferase:Glycosyltransferases involved in cell wall biogenesis:Predicted Fe-S oxidoreductases:Predicted GTPase:Predicted thioesterase:NADH:ubiquinone oxidoreductase subunit 3 (chain A):Fe-S oxidoreductase:Peroxiredoxin:Lauroyl/myristoyl acyltransferase:NADH:flavin oxidoreductases, Old Yellow Enzyme family:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase:Amino acid transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Lipopolysaccharide biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:orni_carb_tr:DAHP_synth_Bsub:degP_htrA_DO:Obg_CgtA:Degradation of proteins, peptides, and glycopeptides:Protein fate:Other:Protein synthesis:Metabolism:Metabolism:Global:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Cellular processes and signaling:Energy Metabolism:Metabolism:Poorly characterized:Glutamate family:Aromatic amino acid family:Amino acid biosynthesis" 120 "Putative translation factor (SUA5):Pseudouridine synthase:Dethiobiotin synthetase:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Ribosomal protein S15P/S13E:Transcription elongation factor:Biotin synthase and related enzymes:Translation initiation factor 2 (IF-2; GTPase):Predicted Zn-dependent peptidases:Exopolyphosphatase-related proteins:Predicted transcriptional regulators:Uncharacterized protein conserved in bacteria:Ribosome-binding factor A:Cytidylate kinase:Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase):Predicted nucleic-acid-binding protein implicated in transcription termination:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Purine metabolism:Pyrimidine metabolism:Biotin metabolism:Metabolic pathways:Ribosome:RNA degradation:General function prediction only:Function unknown:TIGR00057:rbfA:small_GTP:bioD:TruB:bioB:bioA:S15_bact:NusA:polynuc_phos:Poorly characterized:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Global:Metabolism:Transcription:Degradation of RNA:Transcription factors:RNA processing:Protein synthesis:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Information storage and processing:Metabolism:Metabolism" 121 "Shikimate 5-dehydrogenase:6-phosphofructokinase:Integral membrane protein possibly involved in chromosome condensation:Glutamate 5-kinase:Predicted Zn-dependent peptidases:Signal transduction histidine kinase:Fe2+/Zn2+ uptake regulation proteins:Predicted periplasmic solute-binding protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:DNA uptake lipoprotein:Signal transduction histidine kinase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Galactose metabolism:Arginine and proline metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:TIGR00247:crcB:aroE:proB:PFKA_ATP:OM_YfiO:HpnK:Small molecule interactions:Regulatory functions:Glycolysis/gluconeogenesis:Energy metabolism:Metabolism:Metabolism:Global:Amino Acid Metabolism:Energy Metabolism:Protein fate:Carbohydrate Metabolism:Protein and peptide secretion and trafficking:Hypothetical proteins:Conserved:Unknown function:General:Amino acid biosynthesis:Aromatic amino acid family:Glutamate family:Cellular processes and signaling:Metabolism:Poorly characterized" 122 "Energy production and conversion:Dihydroorotase and related cyclic amidohydrolases:DNA mismatch repair enzyme (predicted ATPase):Glutamate dehydrogenase/leucine dehydrogenase:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Signal transduction histidine kinase:Predicted xylanase/chitin deacetylase:Nitroreductase:Methyl-accepting chemotaxis protein:Membrane-fusion protein:Predicted branched-chain amino acid permease (azaleucine resistance):Outer membrane protein:Uncharacterized conserved protein:FOG: PAS/PAC domain:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Predicted symporter:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Nitrogen metabolism:Metabolic pathways:Mismatch repair:General function prediction only:Function unknown:Signal transduction mechanisms:YaeB_AF0241:sensory_box:mutl:sss:pyrC_multi:RND_mfp:M6dom_TIGR03296:antibiot_sagB:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Replication and Repair:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Unknown substrate:Cations and iron carrying compounds:Unknown function:Enzymes of unknown specificity:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 123 "Acetylglutamate semialdehyde dehydrogenase:Small-conductance mechanosensitive channel:Alanine dehydrogenase:Pyruvate-formate lyase-activating enzyme:Amidases related to nicotinamidase:Transposase and inactivated derivatives:Amino acid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Lysine biosynthesis:Arginine and proline metabolism:Taurine and hypotaurine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:alaDH:argC:Amino acid biosynthesis:Amino Acid Metabolism:Metabolism of Other Amino Acids:Global:Metabolism:Energy metabolism:Amino acids and amines:Metabolism:Glutamate family:Information storage and processing:Cellular processes and signaling:Metabolism" 124 "Energy production and conversion:Glycosyltransferases involved in cell wall biogenesis:rRNA methylase:Uncharacterized membrane-associated protein:UDP-N-acetyl-D-mannosaminuronate dehydrogenase:dUTPase:Ferredoxin:Uncharacterized protein involved in exopolysaccharide biosynthesis:Uncharacterized conserved protein:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Pyrimidine metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Function unknown:rRNA_methyl_1:dut:NDP-sugDHase:Cellular processes and signaling:Carbohydrate Metabolism:Nucleotide Metabolism:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:Protein synthesis:tRNA and rRNA base modification:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 125 "Pentose-5-phosphate-3-epimerase:Glutamate decarboxylase and related PLP-dependent proteins:Phosphoglycerate dehydrogenase and related dehydrogenases:Sulfite reductase, beta subunit (hemoprotein):Cytosine deaminase and related metal-dependent hydrolases:Panthothenate synthetase:Predicted Fe-S oxidoreductases:Organic radical activating enzymes:tmRNA-binding protein:6-pyruvoyl-tetrahydropterin synthase:Parvulin-like peptidyl-prolyl isomerase:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:Periplasmic component of the Tol biopolymer transport system:Uncharacterized protein, putative amidase:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Outer membrane lipoprotein-sorting protein:Uncharacterized protein conserved in bacteria:Signal transduction protein containing GAF and PtsI domains:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Pentose phosphate pathway:Pentose and glucuronate interconversions:Fatty acid biosynthesis:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Arginine and proline metabolism:beta-Alanine metabolism:Taurine and hypotaurine metabolism:Butanoate metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Phosphotransferase system (PTS):General function prediction only:Function unknown:Signal transduction mechanisms:panC:smpB:rpe:PGDH:PTS_I_fam:propeller_TolB:queuosine_QueD:HpnH:NOD_PanD_pyr:TIGR03987:Intracellular trafficking, secretion, and vesicular transport:Amino acid biosynthesis:Pathogenesis:Cellular processes:tRNA and rRNA base modification:Other:Protein synthesis:Pentose phosphate pathway:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Pantothenate and coenzyme A:Biosynthesis of cofactors, prosthetic groups, and carriers:Serine family" 126 "Energy production and conversion:Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase:5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase:Orotidine-5'-phosphate decarboxylase:Phosphopantothenoylcysteine synthetase/decarboxylase:ATP-dependent Zn proteases:Isocitrate/isopropylmalate dehydrogenase:ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member:Chemotaxis protein histidine kinase and related kinases:Preprotein translocase subunit SecA (ATPase, RNA helicase):cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:5,10-methylenetetrahydrofolate reductase:Methyl-accepting chemotaxis protein:Enoyl-CoA hydratase/carnithine racemase:Fe-S oxidoreductase:Heterodisulfide reductase, subunit A and related polyferredoxins:Pyruvate-formate lyase-activating enzyme:Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins:L-lactate permease:Beta-lactamase class C and other penicillin binding proteins:Pirin-related protein:Coenzyme F420-reducing hydrogenase, delta subunit:Heterodisulfide reductase, subunit B:Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:FOG: PAS/PAC domain:Alpha-tubulin suppressor and related RCC1 domain-containing proteins:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Valine leucine and isoleucine biosynthesis:Glyoxylate and dicarboxylate metabolism:Butanoate metabolism:One carbon pool by folate:Methane metabolism:Carbon fixation pathways in prokaryotes:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Protein export:Bacterial secretion system:Homologous recombination:General function prediction only:Signal transduction mechanisms:leuB:sensory_box:coaBC_dfp:secA:FtsH_fam:recD:pyrF:PFLE_PFLC:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Cytoskeleton:Pyruvate family:Amino acid biosynthesis:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking:Protein fate:DNA replication, recombination, and repair:DNA metabolism:Small molecule interactions:Regulatory functions:Pyrimidine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Membrane Transport:Environmental Information Processing:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Pantothenate and coenzyme A:Biosynthesis of cofactors, prosthetic groups, and carriers" 127 "Glutamine amidotransferase:Thioredoxin reductase:Transcriptional regulator:Predicted Zn-dependent peptidases:Predicted metal-dependent phosphoesterases (PHP family):Nucleoside phosphorylase:Collagenase and related proteases:ADP-ribose pyrophosphatase:Amidases related to nicotinamidase:Uncharacterized conserved protein:Carbon starvation protein, predicted membrane protein:Anti-sigma regulatory factor (Ser/Thr protein kinase):Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Uncharacterized protein involved in outer membrane biogenesis:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Cysteine and methionine metabolism:Histidine metabolism:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:IMP_synth_hisH:fut_nucase:Metabolism:Poorly characterized:Metabolism:Global:Metabolism:Cell Motility:Cellular Processes:Cellular processes and signaling:Signal Transduction:Environmental Information Processing:Information storage and processing:Histidine family:Amino Acid Metabolism:Amino acid biosynthesis:Energy Metabolism" 128 "Energy production and conversion:Mg-dependent DNase:Lipoate-protein ligase B:Predicted hydrolase of the metallo-beta-lactamase superfamily:Thiamine monophosphate kinase:Periplasmic protease:Methyl-accepting chemotaxis protein:Predicted alternative thymidylate synthase:Lauroyl/myristoyl acyltransferase:DNA segregation ATPase FtsK/SpoIIIE and related proteins:Predicted redox protein, regulator of disulfide bond formation:Predicted metal-dependent hydrolase:NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit:NADH:ubiquinone oxidoreductase 24 kD subunit:Uncharacterized protein involved in outer membrane biogenesis:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Pyrimidine metabolism:Lipopolysaccharide biosynthesis:One carbon pool by folate:Thiamine metabolism:Lipoic acid metabolism:Metabolic pathways:RNA degradation:General function prediction only:Signal transduction mechanisms:TIGR00010:lipB:prc:MG423:thiL:thyX:Enzymes of unknown specificity:Energy Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:Protein fate:Protein modification and repair:Hypothetical proteins:Conserved:Unknown function:Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 129 "Energy production and conversion:NADPH:quinone reductase and related Zn-dependent oxidoreductases:Fe2+/Zn2+ uptake regulation proteins:ABC-type multidrug transport system, permease component:Sec-independent protein secretion pathway components:AraC-type DNA-binding domain-containing proteins:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:ABC transporters:Protein export:Bacterial secretion system:General function prediction only:Function unknown:tatB:quinone_pig3:CydD:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Poorly characterized:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Protein fate:Protein and peptide secretion and trafficking:Unknown function:Enzymes of unknown specificity:Information storage and processing:Cellular processes and signaling:Metabolism:Genetic Information Processing" 130 "tRNA and rRNA cytosine-C5-methylases:3-oxoacyl-(acyl-carrier-protein) synthase:Zn-dependent hydrolases, including glyoxylases:ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member:Transcriptional regulator:tRNA nucleotidyltransferase/poly(A) polymerase:Sulfate permease and related transporters (MFS superfamily):Thioredoxin-like proteins and domains:Predicted transcriptional regulators:Membrane-fusion protein:ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component:Predicted helicases:Peroxiredoxin:Hemerythrin:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Uncharacterized metal-binding protein:ABC-type uncharacterized transport system, permease component:ABC-type transport system, involved in lipoprotein release, permease component:ABC-type anion transport system, duplicated permease component:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Metabolic pathways:ABC transporters:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:sulP:cas3_core:RND_mfp:casD_Cas5e:hemeryth_dom:CxxC_CxxC_SSSS:VI_chp_6:VI_chp_7:Poorly characterized:Lipid Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Regulatory functions:DNA interactions:Transport and binding proteins:Unknown substrate:Anions:Cellular processes:Pathogenesis:Mobile and extrachromosomal element functions:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 131 "Phosphoribosylanthranilate isomerase:Anthranilate/para-aminobenzoate synthases component I:Glycosyltransferase:Glycosyltransferases involved in cell wall biogenesis:Threonine synthase:Methyl-accepting chemotaxis protein:Polyphosphate kinase:ADP-heptose:LPS heptosyltransferase:UDP-glucose 4-epimerase:ABC-type multidrug transport system, ATPase component:Predicted glycosyltransferases:Multidrug resistance efflux pump:Uncharacterized conserved protein:Arabinose efflux permease:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Galactose metabolism:Oxidative phosphorylation:Glycine serine and threonine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Vitamin B6 metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:RNA degradation:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00159:thrC:trpE_most:efflux_EmrB:galE:drrA:heptsyl_trn_I:heptsyl_trn_II:poly_P_kin:Defense mechanisms:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Phosphorus compounds:Energy metabolism:Sugars:Transport and binding proteins:Other:Hypothetical proteins:Conserved:Amino acid biosynthesis:Aromatic amino acid family:Aspartate family:Cell envelope:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 132 "Carbamoylphosphate synthase large subunit (split gene in MJ):Outer membrane protein:Predicted Rossmann fold nucleotide-binding protein:Uncharacterized protein conserved in bacteria:Flagellar biosynthesis/type III secretory pathway lipoprotein:Sugar phosphate permease:Predicted transcriptional regulator:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Metabolic pathways:Flagellar assembly:Bacterial secretion system:General function prediction only:Function unknown:fliF:TIGR00730:CPSaseII_lrg:IV_VI_DotU:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Nucleotide Metabolism:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Cellular processes:Pathogenesis:Chemotaxis and motility:Hypothetical proteins:Conserved:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 133 "Energy production and conversion:Succinyl-CoA synthetase, beta subunit:Uncharacterized conserved protein:ATP-dependent Lon protease, bacterial type:Superfamily II DNA and RNA helicases:Superfamily II DNA helicase:MoxR-like ATPases:ABC-type transport system involved in resistance to organic solvents, permease component:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Predicted Fe-S oxidoreductase:NADH dehydrogenase, FAD-containing subunit:Transcriptional regulator:Triphosphoribosyl-dephospho-CoA synthetase:Uncharacterized conserved protein:HD-GYP domain:ABC-type tungstate transport system, periplasmic component:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Propanoate metabolism:C5-Branched dibasic acid metabolism:Carbon fixation pathways in prokaryotes:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00056:TIGR00149_YbjQ:recQ_fam:lon:sucCoAbeta:TIGR01212:folK:Metabolism:Cellular processes and signaling:Information storage and processing:Folic acid:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function:Conserved:Hypothetical proteins:Degradation of proteins, peptides, and glycopeptides:Protein fate:DNA replication, recombination, and repair:DNA metabolism:TCA cycle:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism" 134 "DnaJ-class molecular chaperone with C-terminal Zn finger domain:Glutaredoxin and related proteins:Primosomal protein N' (replication factor Y) - superfamily II helicase:Protoporphyrinogen oxidase:Metal-dependent amidase/aminoacylase/carboxypeptidase:Transcriptional regulators:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Putative Ser protein kinase:Signal transduction histidine kinase:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Homologous recombination:General function prediction only:Signal transduction mechanisms:sensory_box:proto_IX_ox:priA:amidohydrolases:Cellular processes and signaling:Metabolism:Poorly characterized:Degradation of proteins, peptides, and glycopeptides:Protein fate:DNA replication, recombination, and repair:DNA metabolism:Small molecule interactions:Regulatory functions:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism of Cofactors and Vitamins:Heme, porphyrin, and cobalamin:Information storage and processing" 135 "Energy production and conversion:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:FOG: CBS domain:Branched-chain amino acid ABC-type transport system, permease components:ABC-type branched-chain amino acid transport systems, periplasmic component:Predicted xylanase/chitin deacetylase:Transcriptional regulator:Coenzyme F420-reducing hydrogenase, alpha subunit:Uncharacterized protein conserved in bacteria:P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein:ABC-type branched-chain amino acid transport system, permease component:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Cell motility:Inorganic ion transport and metabolism:ABC transporters:General function prediction only:Function unknown:Signal transduction mechanisms:paired_CXXCH_1:M6dom_TIGR03296:VI_chp_4:Intracellular trafficking, secretion, and vesicular transport:Environmental Information Processing:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Pathogenesis:Cellular processes:Membrane Transport" 136 "Energy production and conversion:3-isopropylmalate dehydratase large subunit:Fructose-1,6-bisphosphatase:F0F1-type ATP synthase, subunit a:Uncharacterized conserved protein:ABC-type branched-chain amino acid transport systems, ATPase component:Acetyltransferases:Pyridoxal phosphate biosynthesis protein:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Predicted P-loop-containing kinase:Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB:Transcriptional regulators:Tfp pilus assembly protein PilP:Type II secretory pathway, component HofQ:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell motility:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Oxidative phosphorylation:Valine leucine and isoleucine biosynthesis:C5-Branched dibasic acid metabolism:Methane metabolism:Vitamin B6 metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:pdxJ:ATP_synt_6_or_A:hacA_fam:rimI:IV_pilus_PilQ:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Protein synthesis:Ribosomal proteins: synthesis and modification:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridoxine:Cell envelope:Surface structures:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 137 "Energy production and conversion:Isopropylmalate/homocitrate/citramalate synthases:Transaldolase:S-adenosylmethionine synthetase:Nuclease subunit of the excinuclease complex:Topoisomerase IA:Transcriptional regulator:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Predicted permeases:Zn-dependent alcohol dehydrogenases:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Phosphoenolpyruvate carboxykinase (GTP):Cell shape-determining protein:Transcriptional regulators:Uncharacterized conserved protein:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Pentose phosphate pathway:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Selenocompound metabolism:Pyruvate metabolism:Thiamine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Nucleotide excision repair:Sulfur relay system:General function prediction only:Function unknown:uvrC:mreC:fsa_talC_mipB:leuA_bact:metK:topA_bact:TAT_signal_seq:FeS_nifS:shape_MreD:Cellular processes and signaling:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Global:Metabolism:Central intermediary metabolism:Other:Energy metabolism:Pentose phosphate pathway:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking:Amino acid biosynthesis:Pyruvate family:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 138 "Nuclease subunit of the excinuclease complex:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Predicted Fe-S oxidoreductases:Chemotaxis signal transduction protein:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Tfp pilus assembly protein, tip-associated adhesin PilY1:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Flagellar basal body rod protein:Tfp pilus assembly protein FimT:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Two-component system:Bacterial chemotaxis:Flagellar assembly:Nucleotide excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:uvrC:flgG_G_neg:IV_pilin_GFxxxE:rSAM_for_selen:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Chemotaxis and motility:Genetic Information Processing:Cellular processes and signaling:Poorly characterized" 139 "Glutamate-1-semialdehyde aminotransferase:Xaa-Pro aminopeptidase:Chorismate synthase:Folate-dependent phosphoribosylglycinamide formyltransferase PurN:3-dehydroquinate synthetase:Predicted Fe-S-cluster redox enzyme:Lysine 2,3-aminomutase:Low specificity phosphatase (HAD superfamily):Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding):Outer membrane receptor for ferrienterochelin and colicins:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Inorganic ion transport and metabolism:Purine metabolism:Valine leucine and isoleucine degradation:Lysine degradation:Phenylalanine tyrosine and tryptophan biosynthesis:Lipopolysaccharide biosynthesis:Propanoate metabolism:One carbon pool by folate:Carbon fixation pathways in prokaryotes:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:aroC:TIGR00048:TIGR00238:PurN:acid_CoA_mut_C:hemL:aroB:YrbI-phosphatas:Biosynthesis of cofactors, prosthetic groups, and carriers:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Energy metabolism:Electron transport:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:tRNA and rRNA base modification:Amino acid biosynthesis:Aromatic amino acid family:Metabolism:Heme, porphyrin, and cobalamin:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Metabolism:Poorly characterized" 140 "Energy production and conversion:Cysteine synthase:tRNA and rRNA cytosine-C5-methylases:Ribonuclease HII:Guanylate kinase:Protein chain release factor A:Ribosomal protein L31:Acetyl-CoA hydrolase:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:Glycerol-3-phosphate dehydrogenase:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:UDP-3-O-acyl-N-acetylglucosamine deacetylase:ABC-type multidrug transport system, permease component:ABC-type Na+ efflux pump, permease component:Transcriptional regulators:Phosphohistidine phosphatase SixA:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Peptide chain release factor RF-3:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Lipopolysaccharide biosynthesis:Peptidoglycan biosynthesis:Glycerophospholipid metabolism:Sulfur metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Ribosome:DNA replication:Function unknown:Signal transduction mechanisms:prfA:L31:sensory_box:small_GTP:GGDEF:HDIG:lpxC:mraY:murG:cysKM:MJ0042_CXXC:guanyl_kin:Defense mechanisms:Cellular processes and signaling:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Regulatory functions:Small molecule interactions:Protein synthesis:Ribosomal proteins: synthesis and modification:Translation factors:Unknown function:General:Amino acid biosynthesis:Serine family:Signal transduction:Other:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 141 "Energy production and conversion:Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):ABC-type phosphate transport system, permease component:Signal transduction histidine kinase:Ni,Fe-hydrogenase maturation factor:Methyl-accepting chemotaxis protein:Predicted GTPases:Outer membrane protein:Predicted signal transduction protein:Flagellar basal-body P-ring protein:Predicted metal-dependent hydrolase of the TIM-barrel fold:Arabinose efflux permease:Predicted transcriptional regulator:Signal transduction histidine kinase, nitrogen specific:Predicted spermidine synthase with an N-terminal membrane domain:Type III secretory pathway, component EscT:Signal transduction histidine kinase:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:beta-Alanine metabolism:Glutathione metabolism:Metabolic pathways:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Signal transduction mechanisms:efp:hydrog_prot:TIGR00157:sensory_box:efflux_Bcr_CflA:3a0107s02c:fliR:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Information storage and processing:Chemotaxis and motility:Cellular processes:Anions:Transport and binding proteins:Translation factors:Protein synthesis:Small molecule interactions:Regulatory functions:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Membrane Transport:Environmental Information Processing:Metabolism of Other Amino Acids:Poorly characterized:Amino Acid Metabolism:Metabolism" 142 "Energy production and conversion:Phosphotransacetylase:1,4-alpha-glucan branching enzyme:Recombinational DNA repair protein (RecF pathway):Glycosidases:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:FOG: CBS domain:Branched-chain amino acid ABC-type transport system, permease components:Small-conductance mechanosensitive channel:ABC-type branched-chain amino acid transport systems, periplasmic component:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Nitrate/nitrite transporter:Predicted membrane protein:Predicted symporter:ABC-type branched-chain amino acid transport system, permease component:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Taurine and hypotaurine metabolism:Starch and sucrose metabolism:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:recR:pta:sss:trehalose_TreZ:treS_nterm:Metabolism:Cellular processes and signaling:Information storage and processing:Cations and iron carrying compounds:Transport and binding proteins:DNA replication, recombination, and repair:DNA metabolism:Biosynthesis and degradation of polysaccharides:Fermentation:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Metabolism of Other Amino Acids:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism" 143 "Dihydroorotate dehydrogenase:Preprotein translocase subunit SecF:ABC-type branched-chain amino acid transport systems, ATPase component:Predicted redox protein, regulator of disulfide bond formation:Phosphopantetheine adenylyltransferase:Phosphomannomutase:Coenzyme F390 synthetase:Type II secretory pathway, pseudopilin PulG:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Type II secretory pathway, component PulK:Cytochrome c biogenesis factor:Type II secretory pathway, component PulJ:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Phenylalanine metabolism:Amino sugar and nucleotide sugar metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:ABC transporters:Protein export:Bacterial secretion system:cyt_tran_rel:2A0604s01:pyrD_sub1_fam:glmM:typeII_sec_gspG:IV_pilin_GFxxxE:Pal_lipo:selenium_YedF:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Amino sugars:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Pathogenesis:Metabolism:Metabolism" 144 "Energy production and conversion:Dihydropteroate synthase and related enzymes:Predicted permease:Ni,Fe-hydrogenase maturation factor:5,10-methylenetetrahydrofolate reductase:Mannose-1-phosphate guanylyltransferase:Membrane-fusion protein:Multisubunit Na+/H+ antiporter, MnhC subunit:NADH:ubiquinone oxidoreductase subunit 2 (chain N):Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type transport system involved in resistance to organic solvents, ATPase component:N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains):Co/Zn/Cd efflux system component:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Oxidative phosphorylation:Amino sugar and nucleotide sugar metabolism:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:unchar_dom_1:CDF:DHPS:RND_mfp:NDH_I_N:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Energy metabolism:Electron transport:Transport and binding proteins:Unknown substrate:Cations and iron carrying compounds:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Cellular processes and signaling:Metabolism:Metabolism" 145 "Energy production and conversion:Uracil phosphoribosyltransferase:5-enolpyruvylshikimate-3-phosphate synthase:Prephenate dehydrogenase:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake:Predicted endonuclease distantly related to archaeal Holliday junction resolvase:NADH:ubiquinone oxidoreductase subunit 6 (chain J):FKBP-type peptidyl-prolyl cis-trans isomerases 2:Ferredoxin:Predicted Fe-S oxidoreductase:Sulfite oxidase and related enzymes:FOG: PAS/PAC domain:Uncharacterized conserved protein:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Signal transduction histidine kinase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:TIGR00252:dprA:upp:TIGR01212:gltA:aroA:Intracellular trafficking, secretion, and vesicular transport:Enzymes of unknown specificity:Unknown function:Conserved:Hypothetical proteins:DNA transformation:Cellular processes:Small molecule interactions:Regulatory functions:Salvage of nucleosides and nucleotides:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Biosynthesis of Other Secondary Metabolites:Amino Acid Metabolism:Nucleotide Metabolism:Glutamate family:Energy Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Aromatic amino acid family:Amino acid biosynthesis" 146 "Energy production and conversion:Thiol-disulfide isomerase and thioredoxins:Predicted transcriptional regulators:Predicted permeases:FOG: CheY-like receiver:Cytochrome c biogenesis protein:Arsenite efflux pump ACR3 and related permeases:ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:PAP2 (acid phosphatase) superfamily protein:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:ABC transporters:Two-component system:Bacterial chemotaxis:General function prediction only:Signal transduction mechanisms:acr3:Cellular Processes:Signal Transduction:Information storage and processing:Membrane Transport:Cellular processes and signaling:Metabolism:Poorly characterized:Environmental Information Processing:Anions:Transport and binding proteins:Cell Motility" 147 "Undecaprenyl pyrophosphate synthase:Preprotein translocase subunit SecF:Nucleotide-binding protein implicated in inhibition of septum formation:Nucleoside-diphosphate-sugar epimerases:Pseudouridylate synthases, 23S RNA-specific:2-methylthioadenine synthetase:Selenophosphate synthase:Bacterial cell division membrane protein:FOG: CheY-like receiver:Alanine racemase:ABC-type transport system involved in resistance to organic solvents, ATPase component:Uncharacterized protein conserved in bacteria:Predicted transcriptional regulators:HrpA-like helicases:Transposase and inactivated derivatives:Xanthine/uracil permeases:Predicted hydrolase (HD superfamily):Uncharacterized conserved protein:ATP phosphoribosyltransferase involved in histidine biosynthesis:Signal transduction histidine kinase:Predicted metal-binding protein:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Histidine metabolism:Selenocompound metabolism:D-Alanine metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00046:uppS:TIGR00089:maf:parB_part:sensory_box:HDIG:hisZ_biosyn_reg:selD:alr:ncs2:paired_CXXCH_1:DEAH_box_HrpB:rodA_shape:HpnN:Intracellular trafficking, secretion, and vesicular transport:Histidine family:Amino acid biosynthesis:Enzymes of unknown specificity:Unknown function:Cell division:Cellular processes:Nucleosides, purines and pyrimidines:Transport and binding proteins:tRNA and rRNA base modification:Protein synthesis:Small molecule interactions:Regulatory functions:Metabolism:Metabolism:Global:Metabolism of Terpenoids and Polyketides:Metabolism of Other Amino Acids:Poorly characterized:Amino Acid Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope" 148 "Tryptophan synthase alpha chain:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase:Signal transduction histidine kinase:Predicted transcriptional regulators:Periplasmic protein TonB, links inner and outer membranes:Selenocysteine synthase [seryl-tRNASer selenium transferase]:Threonine aldolase:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Predicted membrane protein:Signal transduction histidine kinase:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Glycine serine and threonine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Selenocompound metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Function unknown:Signal transduction mechanisms:ispF:sensory_box:trpA:selA:tonB_Cterm:Cellular processes and signaling:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Global:Metabolism:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Cations and iron carrying compounds:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 149 "Energy production and conversion:7-keto-8-aminopelargonate synthetase and related enzymes:3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes:Predicted redox protein, regulator of disulfide bond formation:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:ABC-type sulfate transport system, permease component:Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):ABC-type sulfate/molybdate transport systems, ATPase component:ABC-type sulfate transport system, periplasmic component:Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits:Methylase involved in ubiquinone/menaquinone biosynthesis:GTPases - Sulfate adenylate transferase subunit 1:ABC-type sulfate transport system, permease component:Amino acid transport and metabolism:Coenzyme transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Glycine serine and threonine metabolism:Selenocompound metabolism:Sulfur metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:small_GTP:bioF:3a0106s01:3a0106s02:3a0106s03:APS_reductase:BioC:Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Sulfur metabolism:Transport and binding proteins:Anions:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Cellular processes and signaling:Metabolism:Poorly characterized" 150 "Energy production and conversion:Isopropylmalate/homocitrate/citramalate synthases:Nicotinate-nucleotide pyrophosphorylase:ABC-type phosphate transport system, periplasmic component:GMP synthase - Glutamine amidotransferase domain:Predicted Fe-S oxidoreductases:ABC-type molybdate transport system, periplasmic component:Flagellar capping protein:Nitrogenase subunit NifH (ATPase):ADP-ribosylglycohydrolase:Flagellin-specific chaperone FliS:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Uncharacterized conserved protein:NCAIR mutase (PurE)-related proteins:Nitrogenase molybdenum-iron protein, alpha and beta chains:Retron-type reverse transcriptase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Lysine biosynthesis:Pyruvate metabolism:Chloroalkane and chloroalkene degradation:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Flagellar assembly:RNA polymerase:General function prediction only:Function unknown:fliS:TIGR00299:modA:nifD:nifE:nifH:modD:C_GCAxxG_C_C:ptsS_2:nifV_homocitr:dinitro_DRAG:sigma70-ECF:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Transcription:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Nitrogen fixation:Transport and binding proteins:Anions:Cellular processes:Chemotaxis and motility:Hypothetical proteins:Conserved:Unknown function:General:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 151 "Glycosyltransferase:ATPases of the AAA+ class:Cytochrome c peroxidase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Phage protein D:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR02241:tail_TIGR02242:TIGR02243:Metabolism:Cellular processes and signaling:Prophage functions:Mobile and extrachromosomal element functions:Poorly characterized" 152 "Energy production and conversion:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Uncharacterized conserved protein:Predicted membrane protein:Predicted transcriptional regulator:Predicted permeases:ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components:Amino acid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:ABC transporters:General function prediction only:Function unknown:oligo_HPY:CydD:Transport and binding proteins:Poorly characterized:Membrane Transport:Metabolism:Environmental Information Processing:Cellular processes and signaling:Information storage and processing:Amino acids, peptides and amines" 153 "Energy production and conversion:Lipoate-protein ligase A:Lipoate synthase:Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain:Glycine cleavage system H protein (lipoate-binding):Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily):Cytochrome c biogenesis protein:Methyl-accepting chemotaxis protein:Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Flagellar motor component:Cobyric acid synthase:Predicted redox protein, regulator of disulfide bond formation:Multisubunit Na+/H+ antiporter, MnhE subunit:Threonine aldolase:Uncharacterized conserved protein:Precorrin-4 methylase:Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase):Signal transduction histidine kinase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Pyruvate metabolism:Lipoic acid metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:cobQ:lipA:gcvH:lipoamide_DH:cobM_cbiF:Lipoate:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:Small molecule interactions:Regulatory functions:Amino acids and amines:Energy metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling" 154 "Energy production and conversion:Ribosomal protein S2:Nucleoside diphosphate kinase:Fructose-1,6-bisphosphatase:dGTP triphosphohydrolase:Ribosomal protein L21:Translation initiation factor 3 (IF-3):Uridylate kinase:F0F1-type ATP synthase, subunit b:Bacterial nucleoid DNA-binding protein:Predicted transcriptional regulators:Ribosomal protein L25 (general stress protein Ctc):Predicted RNA-binding protein (contains KH domain):Transcriptional regulators:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:General function prediction only:Function unknown:L21:infC:ctc_TL5:rpsB_bact:dGTP_triPase:pyrH_bact:Translation factors:Ribosomal proteins: synthesis and modification:Protein synthesis:Nucleotide and nucleoside interconversions:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Translation:Genetic Information Processing:Nucleotide Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Information storage and processing" 155 "Signal transduction histidine kinase:Predicted permeases:FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:Membrane-fusion protein:Multisubunit Na+/H+ antiporter, MnhG subunit:Predicted inhibitor of MCP methylation, homolog of CheC:Uncharacterized protein conserved in bacteria:Gluconolactonase:Putative silver efflux pump:Signal transduction histidine kinase:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:2A0601:CPA3_mnhG_phaG:RND_mfp:paired_CXXCH_1:Poorly characterized:Signal Transduction:Cellular Processes:Cell Motility:Regulatory functions:Small molecule interactions:Transport and binding proteins:Unknown substrate:Cations and iron carrying compounds:Cellular processes and signaling:Metabolism:Environmental Information Processing" 156 "Energy production and conversion:Mannose-6-phosphate isomerase:Methyl-accepting chemotaxis protein:ABC-type polar amino acid transport system, ATPase component:Fe-S oxidoreductase, related to NifB/MoaA family:Acyl dehydratase:Precorrin-4 methylase:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell motility:Fructose and mannose metabolism:Amino sugar and nucleotide sugar metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Signal transduction mechanisms:cobM_cbiF:Biosynthesis of cofactors, prosthetic groups, and carriers:Carbohydrate Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Metabolism:Heme, porphyrin, and cobalamin:Cellular processes and signaling:Metabolism" 157 "Energy production and conversion:Ni,Fe-hydrogenase I large subunit:Uncharacterized conserved protein:Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family:Sugar kinases, ribokinase family:FOG: CheY-like receiver:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Fe-S oxidoreductase:Uncharacterized protein predicted to be involved in DNA repair:Predicted inhibitor of MCP methylation, homolog of CheC:Uncharacterized protein predicted to be involved in DNA repair:Predicted transcriptional regulators:Uncharacterized conserved protein:Phosphohistidine phosphatase SixA:Regulator of cell morphogenesis and NO signaling:Predicted transcriptional regulator:Tfp pilus assembly protein, tip-associated adhesin PilY1:Predicted periplasmic ligand-binding sensor domain:Signal transduction histidine kinase:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell motility:Streptomycin biosynthesis:Inositol phosphate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Function unknown:Signal transduction mechanisms:sensory_box:cas1:cas2:C_GCAxxG_C_C:FeS_repair_RIC:Intracellular trafficking, secretion, and vesicular transport:Regulatory functions:Metabolism:Global:Cell Motility:Cellular Processes:Metabolism:Signal Transduction:Environmental Information Processing:Biosynthesis of Other Secondary Metabolites:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Mobile and extrachromosomal element functions:Small molecule interactions" 158 "Energy production and conversion:Xanthosine triphosphate pyrophosphatase:Hydrogenase maturation factor:Asparagine synthase (glutamine-hydrolyzing):Signal transduction histidine kinase:RNase PH:dUTPase:FOG: CheY-like receiver:S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase):ADP-heptose:LPS heptosyltransferase:ABC-type transport system involved in resistance to organic solvents, ATPase component:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Ni,Fe-hydrogenase III large subunit:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Thiamine metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:Signal transduction mechanisms:TIGR00042:hypC_hupF:queA:sensory_box:GGDEF:dut:asn_synth_AEB:RNasePH:PEP_resp_reg:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Transcription:DNA replication, recombination, and repair:DNA metabolism:Small molecule interactions:DNA interactions:Regulatory functions:2'-Deoxyribonucleotide metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:RNA processing:Energy Metabolism:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein modification and repair:Amino acid biosynthesis:Aspartate family:Signal transduction:Other" 159 "Energy production and conversion:Signal transduction histidine kinase:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Predicted hydrolase (HAD superfamily):ABC-type multidrug transport system, ATPase component:4-diphosphocytidyl-2-methyl-D-erithritol synthase:Outer membrane protein:Sec-independent protein secretion pathway components:Transcriptional regulators:Predicted peroxiredoxins:Predicted membrane protein:Plasmid stabilization system protein:Uncharacterized conserved protein:Signal transduction histidine kinase:Uncharacterized conserved protein:Polysulphide reductase:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:ispD:drrA:tatAE:HAD-SF-IA-v3:phd_fam:PEP_his_kin:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function:Other:Mobile and extrachromosomal element functions:Other:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Small molecule interactions:Regulatory functions:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Other:Metabolism of Terpenoids and Polyketides:Signal transduction:Two-component systems:Information storage and processing:Cellular processes and signaling:Metabolism" 160 "Energy production and conversion:Gamma-glutamyl phosphate reductase:Pentose-5-phosphate-3-epimerase:GTPases - translation elongation factors:Mg-dependent DNase:Delta-aminolevulinic acid dehydratase:Argininosuccinate synthase:tRNA and rRNA cytosine-C5-methylases:Glutamate 5-kinase:Phosphoglyceromutase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Nucleoside phosphorylase:Uncharacterized homolog of plant Iojap protein:Aconitase A:Nicotinic acid mononucleotide adenylyltransferase:Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I):Recombinational DNA repair protein (RecF pathway):DNA segregation ATPase FtsK/SpoIIIE and related proteins:Predicted periplasmic solute-binding protein:FOG: GAF domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized protein involved in an early stage of isoprenoid biosynthesis:Signal transduction histidine kinase regulating phosphoglycerate transport system:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Pentose phosphate pathway:Pentose and glucuronate interconversions:Oxidative phosphorylation:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Nicotinate and nicotinamide metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00010:argG:iojap_ybeB:cyt_tran_rel:small_GTP:proA:rsmB:reco:proB:rpe:pgm_bpd_ind:aconitase_1:NuoI:fut_nucase:Information storage and processing:Glutamate family:Amino acid biosynthesis:General:Enzymes of unknown specificity:Unknown function:tRNA and rRNA base modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:TCA cycle:Pentose phosphate pathway:Glycolysis/gluconeogenesis:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling" 161 "Energy production and conversion:Predicted GTPase, probable translation factor:Nucleoside diphosphate kinase:Peptidyl-tRNA hydrolase:Ribosomal protein L7/L12:Ribosomal protein L10:Transcription antiterminator:Translation initiation factor 3 (IF-3):Ribosomal protein L35:Ribosomal protein S6:CTP synthase (UTP-ammonia lyase):Uridylate kinase:FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor):Preprotein translocase subunit SecE:F0F1-type ATP synthase, subunit b:Protease subunit of ATP-dependent Clp proteases:Bacterial nucleoid DNA-binding protein:Predicted transcriptional regulators:ATP-dependent protease Clp, ATPase subunit:Ribosomal protein L25 (general stress protein Ctc):Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:Protein export:Bacterial secretion system:rpmI_bact:S21p:TIGR00092:tig:S6:infC:PyrG:clpX:pth:clpP:ctc_TL5:L12:nusG:secE_bact:pyrH_bact:Intracellular trafficking, secretion, and vesicular transport:General:Energy Metabolism:Nucleotide Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Pyrimidine ribonucleotide biosynthesis:Transcription:Transcription factors:Protein synthesis:Other:Ribosomal proteins: synthesis and modification:Translation factors:Protein fate:Protein folding and stabilization:Protein and peptide secretion and trafficking:Degradation of proteins, peptides, and glycopeptides:Unknown function:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism" 162 "Energy production and conversion:F0F1-type ATP synthase, beta subunit:Predicted amidohydrolase:ATPase components of ABC transporters with duplicated ATPase domains:Signal transduction histidine kinase:Parvulin-like peptidyl-prolyl isomerase:ABC-type transport system involved in resistance to organic solvents, permease component:Predicted UDP-glucose 6-dehydrogenase:Actin-like ATPase involved in cell morphogenesis:Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains:Predicted RNA-binding protein containing KH domain, possibly ribosomal protein:Predicted membrane protein:Inorganic pyrophosphatase:Cell cycle control, cell division, chromosome partitioning:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Pentose and glucuronate interconversions:Oxidative phosphorylation:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00056:TIGR00244:RNA_bind_YhbY:mreB:atpD:V_PPase:NDP-sugDHase:ABC_ABC_ChvD:General:Carbohydrate Metabolism:Energy Metabolism:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Regulatory functions:DNA interactions:Transport and binding proteins:Cations and iron carrying compounds:Hypothetical proteins:Conserved:Unknown function:Metabolism:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 163 "3-polyprenyl-4-hydroxybenzoate decarboxylase:Mismatch repair ATPase (MutS family):Rhodanese-related sulfurtransferase:Multisubunit Na+/H+ antiporter, MnhC subunit:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ABC-type transport system involved in resistance to organic solvents, ATPase component:Truncated, possibly inactive, lysyl-tRNA synthetase (class II):UTP:GlnB (protein PII) uridylyltransferase:Uncharacterized protein conserved in bacteria:Predicted phosphoglycerate mutase, AP superfamily:Site-specific recombinase XerD:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Fatty acid biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Methane metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Mismatch repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:apgM:ubiX_pad:genX:radc:mutS1:UTase_glnD:cas_CT1978:recomb_XerD:Enzymes of unknown specificity:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Mobile and extrachromosomal element functions:DNA replication, recombination, and repair:DNA metabolism:Protein interactions:Regulatory functions:Metabolism:Global:Glycolysis/gluconeogenesis:Energy metabolism:Metabolism:Signal Transduction:Environmental Information Processing:Replication and Repair:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Lipid Metabolism:Energy Metabolism:Other:Carbohydrate Metabolism:Unknown function" 164 "Energy production and conversion:Uncharacterized conserved protein:Superfamily I DNA and RNA helicases:Formamidopyrimidine-DNA glycosylase:Site-specific DNA methylase:Trehalose-6-phosphate synthase:Predicted permease:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:DNA polymerase I - 3'-5' exonuclease and polymerase domains:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:Periplasmic protein TonB, links inner and outer membranes:Sugar phosphate isomerases/epimerases:Uncharacterized stress-induced protein:L-lactate permease:Molybdopterin-guanine dinucleotide biosynthesis protein:Ketopantoate reductase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Xanthine/uracil permeases:GTPases:Outer membrane lipoprotein-sorting protein:Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component:Transposase and inactivated derivatives:Membrane carboxypeptidase/penicillin-binding protein:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Cysteine and methionine metabolism:Starch and sucrose metabolism:Peptidoglycan biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00106:mobB:TIGR00255:fpg:pola:apbA_panE:ncs2:tonB_Cterm:PBP_1a_fam:TIGR02757:GTP_HflX:Poorly characterized:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Cations and iron carrying compounds:Nucleosides, purines and pyrimidines:Hypothetical proteins:Conserved:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Pantothenate and coenzyme A:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 165 "Zn-dependent hydrolases, including glyoxylases:Predicted phosphatase/phosphohexomutase:Membrane-fusion protein:Flagellar basal body P-ring biosynthesis protein:Putative multicopper oxidases:FOG: GGDEF domain:Arabinose efflux permease:Predicted cobalamin binding protein:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Two-component system:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:GGDEF:HAD-SF-IA-v1:RND_mfp:flgA_cterm:Cellular processes and signaling:Signal Transduction:Cellular Processes:Cell Motility:Transport and binding proteins:Unknown substrate:Cellular processes:Chemotaxis and motility:Unknown function:Enzymes of unknown specificity:Signal transduction:Other:Environmental Information Processing:Metabolism:Poorly characterized" 166 "Energy production and conversion:Molybdopterin converting factor, large subunit:Fe-S-cluster-containing hydrogenase components 1:Predicted Fe-S oxidoreductases:ABC-type multidrug transport system, ATPase and permease components:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Cation transport ATPase:Uncharacterized protein conserved in bacteria:Uncharacterized protein involved in outer membrane biogenesis:Uncharacterized conserved protein:Polysulphide reductase:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycerophospholipid metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Sulfur relay system:General function prediction only:Function unknown:ATPase_P-type:GSu_C4xC__C2xCH:rSAM_more_4Fe4S:Defense mechanisms:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Global:Metabolism:Cellular processes and signaling:Metabolism:Metabolism" 167 "Energy production and conversion:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:Signal transduction histidine kinase:NADH:ubiquinone oxidoreductase 49 kD subunit 7:NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G):Aconitase A:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit:Uncharacterized conserved protein:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Oxidative phosphorylation:Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Lysine degradation:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Function unknown:Signal transduction mechanisms:acon_putative:sucB:lipoamide_DH:nuoB_fam:NuoG:PDH_E1_alph_y:Poorly characterized:Pyruvate dehydrogenase:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Amino Acid Metabolism:Energy Metabolism:TCA cycle:Carbohydrate Metabolism:Cellular processes and signaling:Metabolism" 168 "Energy production and conversion:Xaa-Pro aminopeptidase:Isopropylmalate/homocitrate/citramalate synthases:Ribonucleotide reductase, alpha subunit:Acetate kinase:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Aspartokinases:Pyruvate carboxylase:Predicted Rossmann fold nucleotide-binding protein:Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB:Phosphotransferase system, HPr-related proteins:Rhodanese-related sulfurtransferase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Taurine and hypotaurine metabolism:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:ackA:asp_kin_monofn:TIGR00730:LeuA_rel:PTS_HPr_family:pyruv_carbox:NrdJ_Z:Aspartate family:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Global:Metabolism:Energy metabolism:Fermentation:Glycolysis/gluconeogenesis:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:Hypothetical proteins:Conserved:Unknown function:General:Amino acid biosynthesis:Metabolism:Signal transduction:PTS:Metabolism:Poorly characterized" 169 "Energy production and conversion:F0F1-type ATP synthase, alpha subunit:3-isopropylmalate dehydratase small subunit:Ribosomal protein L32:Fructose-2,6-bisphosphatase:Thiamine biosynthesis protein ThiC:ABC-type branched-chain amino acid transport systems, periplasmic component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Fe-S oxidoreductase:Aconitase B:Ribosome-associated protein Y (PSrp-1):DNA-directed RNA polymerase, subunit K/omega:NaMN:DMB phosphoribosyltransferase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Membrane protein involved in colicin uptake:Predicted flavin-nucleotide-binding protein:Short-chain alcohol dehydrogenase of unknown specificity:Competence protein ComGC:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Citrate cycle (TCA cycle):Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Valine leucine and isoleucine biosynthesis:Glyoxylate and dicarboxylate metabolism:C5-Branched dibasic acid metabolism:Carbon fixation pathways in prokaryotes:Thiamine metabolism:Riboflavin metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Ribosome:RNA polymerase:General function prediction only:Signal transduction mechanisms:acnB:thiC:rpoZ:yfiA:atpA:rpmF_bact:IV_pilin_GFxxxE:cobT_DBIPRT:ribazole_cobC:Intracellular trafficking, secretion, and vesicular transport:Heme, porphyrin, and cobalamin:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Translation:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:TCA cycle:Transcription:DNA-dependent RNA polymerase:Protein synthesis:Ribosomal proteins: synthesis and modification:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 170 "Energy production and conversion:Glutamate-1-semialdehyde aminotransferase:F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit):UDP-N-acetylglucosamine 2-epimerase:Orotate phosphoribosyltransferase:FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor):F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Uncharacterized protein conserved in bacteria:Protease subunit of ATP-dependent Clp proteases:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Phosphotransferase system, HPr-related proteins:3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases:DNA-binding transcriptional activator of the SARP family:Predicted transcriptional regulator:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Oxidative phosphorylation:Pyrimidine metabolism:Valine leucine and isoleucine degradation:Amino sugar and nucleotide sugar metabolism:Carbon fixation pathways in prokaryotes:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Function unknown:Signal transduction mechanisms:DNA_YbaB_EbfC:tig:wecB:pyrE:clpP:hemL:PTS_HPr_family:ATP_synt_epsi:ATP_synt_c:prismane_assoc:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Electron transport:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Protein fate:Protein folding and stabilization:Degradation of proteins, peptides, and glycopeptides:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Signal transduction:PTS:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 171 "Energy production and conversion:Hydrogenase maturation factor:Fe-S oxidoreductases:Multisubunit Na+/H+ antiporter, MnhG subunit:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Function unknown:hypF:CPA3_mnhG_phaG:Cellular processes and signaling:Poorly characterized:Cations and iron carrying compounds:Transport and binding proteins:Protein modification and repair:Protein fate:Metabolism" 172 "ATP phosphoribosyltransferase:Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase:Glutamine amidotransferase:Methionyl-tRNA formyltransferase:N-formylmethionyl-tRNA deformylase:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:2-methylthioadenine synthetase:UDP-N-acetylglucosamine enolpyruvyl transferase:Serine acetyltransferase:ADP-ribose pyrophosphatase:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:Transcriptional regulator:Squalene cyclase:Uncharacterized conserved protein:Predicted transcriptional regulator:Amino acid transport and metabolism:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cysteine and methionine metabolism:Histidine metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:One carbon pool by folate:Thiamine metabolism:Sulfur metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Sulfur relay system:Function unknown:TIGR00007:hisG:pept_deformyl:TIGR00089:trmU:fmt:rrf2_super:murA:cysE:hopene_cyclase:IMP_synth_hisH:Cell envelope:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Folding Sorting and Degradation:Global:Metabolism:Fatty acid and phospholipid metabolism:Other:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein modification and repair:Unknown function:General:Amino acid biosynthesis:Serine family:Histidine family:Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 173 "Rhodanese-related sulfurtransferase:Predicted phosphatase/phosphohexomutase:Membrane carboxypeptidase (penicillin-binding protein):Predicted membrane-associated HD superfamily hydrolase:D-Tyr-tRNAtyr deacylase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase:DNA polymerase III, gamma/tau subunits:Rhodanese-related sulfurtransferase:Type II secretory pathway, component PulC:Predicted transcriptional regulator:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:DNA replication:Bacterial secretion system:Mismatch repair:Homologous recombination:General function prediction only:Signal transduction mechanisms:TIGR00256:HDIG:HAD-SF-IA-v1:PBP_1a_fam:dnaX_nterm:Intracellular trafficking, secretion, and vesicular transport:Cell envelope:Nucleotide Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Unknown function:Enzymes of unknown specificity:Metabolism:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 174 "Energy production and conversion:Dihydroorotate dehydrogenase:Anaerobic dehydrogenases, typically selenocysteine-containing:Translation elongation factors (GTPases):Zn-dependent hydrolases, including glyoxylases:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:Holliday junction resolvasome, DNA-binding subunit:Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily:Predicted ATP-dependent serine protease:dTDP-4-dehydrorhamnose reductase:GTPase SAR1 and related small G proteins:Uncharacterized membrane protein:Uncharacterized conserved protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Predicted exporter:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:ruvA:small_GTP:sms:pyrD_sub1_fam:rmlD:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Information storage and processing:Nucleotide Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:General:Unknown function:DNA replication, recombination, and repair:DNA metabolism" 175 "Energy production and conversion:DNA polymerase elongation subunit (family B):Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:Molybdopterin biosynthesis enzymes:Signal transduction histidine kinase:Fe-S oxidoreductase:ABC-type Na+ efflux pump, permease component:Electron transfer flavoprotein, beta subunit:Cyclopropane fatty acid synthase and related methyltransferases:Predicted NAD/FAD-binding protein:Predicted membrane protein:Coenzyme transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:General function prediction only:Function unknown:Signal transduction mechanisms:molyb_syn:sensory_box:CxxC_CxxC_SSSS:SAM_YgiQ:Information storage and processing:Enzymes of unknown specificity:Unknown function:Small molecule interactions:DNA interactions:Regulatory functions:Metabolism:Poorly characterized:Cellular processes and signaling" 176 "Energy production and conversion:Carbonic anhydrase:Membrane GTPase LepA:Branched-chain amino acid ABC-type transport system, permease components:Uncharacterized membrane-associated protein:ADP-heptose:LPS heptosyltransferase:Predicted UDP-glucose 6-dehydrogenase:ABC-type antimicrobial peptide transport system, ATPase component:ATPases involved in chromosome partitioning:Lysophospholipase L1 and related esterases:Predicted lipoprotein involved in nitrous oxide reduction:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Limonene and pinene degradation:Nitrogen metabolism:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Function unknown:small_GTP:heptsyl_trn_I:NDP-sugDHase:prismane_assoc:Defense mechanisms:Metabolism:Poorly characterized:General:Unknown function:Electron transport:Metabolism:Global:Energy metabolism:Membrane Transport:Environmental Information Processing:Metabolism of Terpenoids and Polyketides:Glycan Biosynthesis and Metabolism:Lipid Metabolism:Metabolism:Energy Metabolism:Cell envelope:Carbohydrate Metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling" 177 "Multimeric flavodoxin WrbA:Cytidylate kinase:Multidrug resistance efflux pump:Chemotaxis protein; stimulates methylation of MCP proteins:N-terminal domain of molybdenum-binding protein:FOG: GAF domain:Uncharacterized conserved protein:Uncharacterized conserved protein:Putative Ser protein kinase:Predicted DNA-binding protein with the Helix-hairpin-helix motif:Nucleotide transport and metabolism:Cell motility:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:ModE_repress:flav_wrbA:SAM_7_link_chp:rSAM_link_UDG:Defense mechanisms:Cellular Processes:Poorly characterized:Metabolism:Cellular processes and signaling:Enzymes of unknown specificity:Unknown function:Other:Regulatory functions:Electron transport:Energy metabolism:Cell Motility" 178 "Energy production and conversion:Carbamate kinase:Universal stress protein UspA and related nucleotide-binding proteins:Thioredoxin-like proteins and domains:6Fe-6S prismane cluster-containing protein:Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily:Uncharacterized protein conserved in bacteria:Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family:Transcriptional regulators:Uncharacterized conserved protein:Ni,Fe-hydrogenase III small subunit:Delta 1-pyrroline-5-carboxylate dehydrogenase:Kef-type K+ transport system, predicted NAD-binding component:Amino acid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Nitrotoluene degradation:Methane metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Function unknown:Signal transduction mechanisms:D1pyr5carbox2:CO_DH_cata:paired_CXXCH_1:poly_P_AMP_trns:Metabolism:Cellular processes and signaling:Information storage and processing:Amino acids and amines:Energy metabolism:Phosphorus compounds:Central intermediary metabolism:Metabolism:Metabolism:Global:Xenobiotics Biodegradation and Metabolism:Amino Acid Metabolism:Nucleotide Metabolism:Poorly characterized:Energy Metabolism" 179 "Dihydrofolate reductase:Glycosyltransferases involved in cell wall biogenesis:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Uncharacterized protein related to capsule biosynthesis enzymes:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:General function prediction only:Cellular processes and signaling:Poorly characterized:Metabolism" 180 "Nitrogen regulatory protein PII:ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member:tRNA nucleotidyltransferase/poly(A) polymerase:Signal transduction histidine kinase:Uncharacterized protein conserved in bacteria:Predicted transcriptional regulator:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Two-component system:Function unknown:Signal transduction mechanisms:TIGR02270:dnstrm_HI1420:Poorly characterized:Signal Transduction:Mobile and extrachromosomal element functions:Other:Hypothetical proteins:Conserved:Information storage and processing:Cellular processes and signaling:Metabolism:Environmental Information Processing" 181 "Chromatin structure and dynamics:Energy production and conversion:Deacetylases, including yeast histone deacetylase and acetoin utilization protein:Universal stress protein UspA and related nucleotide-binding proteins:Arylsulfatase regulator (Fe-S oxidoreductase):Signal transduction histidine kinase:Sulfate permease and related transporters (MFS superfamily):Cation/multidrug efflux pump:ABC-type cobalt transport system, ATPase component:NADH dehydrogenase, FAD-containing subunit:Putative threonine efflux protein:Predicted transcriptional regulators:Predicted transcriptional regulators:Predicted nucleic acid-binding protein, contains PIN domain:Uncharacterized membrane protein, possible Na+ channel or pump:Flagellar motor switch/type III secretory pathway protein:Tfp pilus assembly protein PilF:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Amino acid transport and metabolism:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:ABC transporters:Bacterial chemotaxis:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:parB_part:sensory_box:sulP:cbiO:fliN:CydC:sigma70-ECF:Nterm_to_SelD:rSAM_more_4Fe4S:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Membrane Transport:Chemotaxis and motility:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Cations and iron carrying compounds:Anions:Environmental Information Processing:Transport and binding proteins:Small molecule interactions:Regulatory functions:Cell Motility:Cellular Processes:Cellular processes" 182 "Energy production and conversion:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit:Fe-S-cluster-containing hydrogenase components 1:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ADP-ribosylglycohydrolase:Glucose/sorbosone dehydrogenases:Aldehyde:ferredoxin oxidoreductase:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Carbohydrate transport and metabolism:Lipid transport and metabolism:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Pentose phosphate pathway:Valine leucine and isoleucine biosynthesis:Lysine degradation:Tryptophan metabolism:Pyruvate metabolism:Butanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:2oxo_dh_E1:GGDEF:sucB:PEP_synth:Poorly characterized:Metabolism:Cellular processes and signaling:Other:Signal transduction:TCA cycle:Metabolism:Global:Amino Acid Metabolism:Glycolysis/gluconeogenesis:Energy metabolism:Energy Metabolism:Metabolism:Carbohydrate Metabolism" 183 "Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase:NAD-dependent DNA ligase (contains BRCT domain type II):ATP-dependent Zn proteases:Kef-type K+ transport systems, membrane components:Pseudouridylate synthases, 23S RNA-specific:Signal transduction histidine kinase:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:DNA polymerase I - 3'-5' exonuclease and polymerase domains:Periplasmic protease:Methyl-accepting chemotaxis protein:Transcription termination factor:Pyruvate-formate lyase-activating enzyme:Uncharacterized protein conserved in bacteria:Pirin-related protein:Transcriptional regulators:FOG: GGDEF domain:Tfp pilus assembly protein, pilus retraction ATPase PilT:Outer membrane lipoprotein-sorting protein:Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component:Uncharacterized conserved protein:Predicted metal-binding protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Valine leucine and isoleucine degradation:Valine leucine and isoleucine biosynthesis:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:RNA degradation:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:Homologous recombination:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00046:prc:GGDEF:dnlj:pola:rho:2a37:ilvE_II:FtsH_fam:pilT_fam:PFLE_PFLC:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein synthesis:tRNA and rRNA base modification:Protein fate:Degradation of proteins, peptides, and glycopeptides:Protein modification and repair:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Chemotaxis and motility:Amino acid biosynthesis:Pyruvate family:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 184 "Energy production and conversion:Thymidylate kinase:Anaerobic dehydrogenases, typically selenocysteine-containing:Predicted amidohydrolase:Fe-S-cluster-containing hydrogenase components 1:Molecular chaperone:DnaJ-class molecular chaperone with C-terminal Zn finger domain:dsRNA-specific ribonuclease:Molecular chaperone GrpE (heat shock protein):Signal transduction histidine kinase:Biopolymer transport proteins:Periplasmic component of the Tol biopolymer transport system:ABC-type antimicrobial peptide transport system, ATPase component:GTPase:Transcriptional regulator of heat shock gene:Uncharacterized protein required for formate dehydrogenase activity:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:DNA polymerase III, gamma/tau subunits:Polysulphide reductase:Nucleotide transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyrimidine metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Metabolic pathways:Microbial metabolism in diverse environments:RNA degradation:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Signal transduction mechanisms:DTMP_kinase:fdhD_narQ:small_GTP:hrcA:holB:tonB_Cterm:TAT_signal_seq:RNaseIII:DnaJ_bact:prok_dnaK:tolQ:propeller_TolB:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:DNA interactions:Regulatory functions:Nucleotide and nucleoside interconversions:Purines, pyrimidines, nucleosides, and nucleotides:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Replication and Repair:Folding Sorting and Degradation:Genetic Information Processing:Nucleotide Metabolism:Energy Metabolism:DNA metabolism:Carbohydrate Metabolism:DNA replication, recombination, and repair:Transcription:RNA processing:Protein fate:Protein folding and stabilization:Protein and peptide secretion and trafficking:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Pathogenesis:Unknown function" 185 "Thiamine monophosphate synthase:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Deoxyribodipyrimidine photolyase:ATPase components of ABC transporters with duplicated ATPase domains:Flagellin and related hook-associated proteins:Carbon storage regulator (could also regulate swarming and quorum sensing):Flagellar basal body-associated protein:Predicted signal transduction protein:Uncharacterized protein conserved in bacteria:Flagellar basal body protein:SOS-response transcriptional repressors (RecA-mediated autopeptidases):Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell motility:Thiamine metabolism:Metabolic pathways:Two-component system:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:csrA:HDIG:lexA:phr2:thiE:FlgB:flagell_flgL:FlgM_jcvi:Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:DNA interactions:RNA interactions:DNA metabolism:DNA replication, recombination, and repair:Cellular processes:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 186 "ATPases involved in chromosome partitioning:Predicted permeases:Methyl-accepting chemotaxis protein:ABC-type Mn/Zn transport systems, ATPase component:ABC-type multidrug transport system, ATPase and permease components:Flagellar biosynthesis/type III secretory pathway ATPase:Flagellar biosynthesis/type III secretory pathway protein:Flagellar biosynthesis pathway, component FliP:Methylase of chemotaxis methyl-accepting proteins:Flagellar GTP-binding protein:Flagellar motor switch protein:Flagellar basal-body P-ring protein:Flagellar basal body L-ring protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Predicted permeases:Flagellar basal body rod protein:Cell cycle control, cell division, chromosome partitioning:Cell motility:Inorganic ion transport and metabolism:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Signal transduction mechanisms:fliG:fliI_yscN:fliP:flgF:FlhF:rSAM_more_4Fe4S:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Membrane Transport:Metabolism:Poorly characterized:Chemotaxis and motility:Cellular processes:Environmental Information Processing:ATP-proton motive force interconversion:Energy metabolism:Cell Motility:Cellular Processes:Signal Transduction:Cellular processes and signaling" 187 "Nicotinate-nucleotide pyrophosphorylase:Transcriptional regulator:Small-conductance mechanosensitive channel:FOG: CheY-like receiver:Phosphatidylglycerophosphatase A and related proteins:Amidases related to nicotinamidase:ADP-ribosylglycohydrolase:Multidrug resistance efflux pump:Large-conductance mechanosensitive channel:N-terminal domain of molybdenum-binding protein:Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism:Uncharacterized protein conserved in bacteria:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycerophospholipid metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:mscL:ModE_repress:phnA:modD:dinitro_DRAG:Defense mechanisms:Metabolism:Cellular processes and signaling:Information storage and processing:General:Unknown function:Adaptations to atypical conditions:Cellular processes:Other:Regulatory functions:Nitrogen fixation:Central intermediary metabolism:Metabolism:Metabolism:Global:Lipid Metabolism:Poorly characterized" 188 "Energy production and conversion:Dienelactone hydrolase and related enzymes:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Galactose-1-phosphate uridylyltransferase:DnaK suppressor protein:Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs:Putative multicopper oxidases:Uncharacterized conserved protein:Lipid transport and metabolism:Galactose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:galT_1:sensory_box:ftsL_broad:cas3_GSU0051:Mobile and extrachromosomal element functions:Carbohydrate Metabolism:Global:Metabolism:Energy metabolism:Sugars:Regulatory functions:Small molecule interactions:Cellular processes:Cell division:Metabolism:Other:Cellular processes and signaling:Metabolism:Poorly characterized" 189 "Energy production and conversion:1-acyl-sn-glycerol-3-phosphate acyltransferase:Uroporphyrinogen-III decarboxylase:Predicted divalent heavy-metal cations transporter:Acetylglutamate kinase:UDP-N-acetyl-D-mannosaminuronate dehydrogenase:FOG: CheY-like receiver:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Phosphomannomutase:Outer membrane protein:Trehalose-6-phosphatase:Coenzyme F420-reducing hydrogenase, gamma subunit:ATP:corrinoid adenosyltransferase:Outer membrane lipoprotein-sorting protein:Type II secretory pathway, component PulC:ABC-type transport system, involved in lipoprotein release, permease component:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Lysine biosynthesis:Arginine and proline metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Methane metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Bacterial secretion system:Signal transduction mechanisms:AGP_acyltrn:cobA:argB:NDP-sugDHase:Intracellular trafficking, secretion, and vesicular transport:Biosynthesis:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Fatty acid and phospholipid metabolism:Metabolism:Amino acid biosynthesis:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cellular processes and signaling:Metabolism" 190 "Thymidylate kinase:Nitrogen regulatory protein PII:Transcriptional regulator:Na+/proline symporter:Predicted permeases:Methyl-accepting chemotaxis protein:ABC-type antimicrobial peptide transport system, ATPase component:Deoxyxylulose-5-phosphate synthase:Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain:Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase:Predicted secreted hydrolase:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell motility:Pyrimidine metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:DTMP_kinase:dxs:sensory_box:Defense mechanisms:Cellular processes and signaling:Nucleotide Metabolism:Metabolism of Terpenoids and Polyketides:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Regulatory functions:Small molecule interactions:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 191 "Glycosyltransferases involved in cell wall biogenesis:Signal transduction histidine kinase:Predicted xylanase/chitin deacetylase:Serine acetyltransferase:Oligoendopeptidase F:Glycosyltransferases, probably involved in cell wall biogenesis:Predicted glycosyltransferases:Membrane protein involved in the export of O-antigen and teichoic acid:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:General function prediction only:Signal transduction mechanisms:sensory_box:M3_fam_3:Metabolism:Cellular processes and signaling:Small molecule interactions:Regulatory functions:Poorly characterized" 192 "Energy production and conversion:Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit:Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II:Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins:Ribosomal protein S1:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):Transcription elongation factor:Pyruvate carboxylase:Putative transcriptional regulator, homolog of Bvg accessory factor:TRAP-type C4-dicarboxylate transport system, periplasmic component:Protein-L-isoaspartate carboxylmethyltransferase:Rhodanese-related sulfurtransferase:ABC-type branched-chain amino acid transport system, permease component:Outer membrane receptor for ferrienterochelin and colicins:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Purine metabolism:Pyruvate metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:ABC transporters:Ribosome:RNA polymerase:Secondary metabolites biosynthesis, transport and catabolism:pimt:baf:gyrA:apt:pyruv_carbox:greB:sigma70-ECF:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein fate:Protein modification and repair:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism" 193 "Energy production and conversion:Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family:Transcriptional regulator:Rieske Fe-S protein:Fe-S oxidoreductases:Fe2+/Zn2+ uptake regulation proteins:ABC-type metal ion transport system, periplasmic component/surface adhesin:4-diphosphocytidyl-2-methyl-D-erithritol synthase:Predicted nucleic acid-binding protein, contains PIN domain:Uncharacterized conserved protein:Transposase and inactivated derivatives:Uncharacterized protein conserved in bacteria:Virulence-associated protein and related proteins:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Streptomycin biosynthesis:Inositol phosphate metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:Function unknown:ispD:TAT_signal_seq:Metabolism:Carbohydrate Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein fate:Protein and peptide secretion and trafficking:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Metabolism:Poorly characterized" 194 "Phosphatidylglycerophosphatase A and related proteins:DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog:Large-conductance mechanosensitive channel:Uncharacterized MobA-related protein:Anti-sigma regulatory factor (Ser/Thr protein kinase):TRAP-type uncharacterized transport system, periplasmic component:Uncharacterized protein conserved in bacteria:Retron-type reverse transcriptase:Uncharacterized conserved protein:Predicted metal-dependent enzyme:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Glycerophospholipid metabolism:Metabolic pathways:RNA polymerase:General function prediction only:Function unknown:Signal transduction mechanisms:mscL:TRAP_TAXI:sigma70-ECF:Metabolism:Lipid Metabolism:Genetic Information Processing:Transcription:Global:Metabolism:Transport and binding proteins:Unknown substrate:Cellular processes:Adaptations to atypical conditions:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 195 "Glycosidases:Glutaredoxin and related proteins:FOG: TPR repeat, SEL1 subfamily:Membrane-fusion protein:Highly conserved protein containing a thioredoxin domain:Uncharacterized protein predicted to be involved in DNA repair:Uncharacterized protein predicted to be involved in DNA repair:Cytochrome c peroxidase:Hemerythrin:Arabinose efflux permease:Carbohydrate transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:General function prediction only:cas1:cas2:RND_mfp:hemeryth_dom:Information storage and processing:Other:Mobile and extrachromosomal element functions:Unknown substrate:Transport and binding proteins:Metabolism:Poorly characterized:Cellular processes and signaling" 196 "Energy production and conversion:Indole-3-glycerol phosphate synthase:Phosphoribosylanthranilate isomerase:Anthranilate/para-aminobenzoate synthases component I:Dihydrodipicolinate reductase:Translation elongation factors (GTPases):Zn-dependent hydrolases, including glyoxylases:Threonine synthase:Anthranilate/para-aminobenzoate synthases component II:2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases:Anthranilate phosphoribosyltransferase:Phosphopantetheinyl transferase (holo-ACP synthase):ABC-type amino acid transport system, permease component:ABC-type polar amino acid transport system, ATPase component:Threonine dehydratase:Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB):Multiple antibiotic transporter:Uncharacterized Fe-S center protein:Uncharacterized protein conserved in bacteria:Type II secretory pathway, component ExeA (predicted ATPase):Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Glycine serine and threonine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Vitamin B6 metabolism:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:dapB:small_GTP:thrC:TIGR00427:acpS:trpE_most:trpG_papA:ilvA_1Cterm:trpD:trpB_rel:HEQRo_perm_3TM:Intracellular trafficking, secretion, and vesicular transport:Enzymes of unknown specificity:Unknown function:Amino acids, peptides and amines:Transport and binding proteins:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Metabolism:Global:Metabolism of Cofactors and Vitamins:Metabolism:Amino Acid Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing:Pyruvate family:Aspartate family:Aromatic amino acid family:Amino acid biosynthesis:General" 197 "Diaminopimelate decarboxylase:Riboflavin synthase beta-chain:3-isopropylmalate dehydratase large subunit:Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase:NAD synthase:Nucleoside-diphosphate-sugar epimerases:Predicted integral membrane protein:FKBP-type peptidyl-prolyl cis-trans isomerases 2:Arginine decarboxylase (spermidine biosynthesis):Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Arginine and proline metabolism:C5-Branched dibasic acid metabolism:Riboflavin metabolism:Nicotinate and nicotinamide metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Function unknown:purC:lumazine-synth:nadE:lysA:speA:hacA_fam:Cellular processes and signaling:Metabolism:Poorly characterized:Biosynthesis of cofactors, prosthetic groups, and carriers:Aspartate family:Amino acid biosynthesis:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Polyamine biosynthesis:Central intermediary metabolism:Metabolism:Global:Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Riboflavin, FMN, and FAD:Carbohydrate Metabolism:Pyridine nucleotides" 198 "Energy production and conversion:Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Protein chain release factor A:Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:Fe-S oxidoreductase:Predicted GTPases:Metal-dependent hydrolases of the beta-lactamase superfamily I:Uncharacterized conserved protein:Deoxycytidylate deaminase:Uncharacterized protein conserved in bacteria:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase, nitrogen specific:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Cell motility:Pyrimidine metabolism:Metabolic pathways:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:prfB:efp:small_GTP:lysidine_TilS_N:Metabolism:Nucleotide Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Protein synthesis:tRNA and rRNA base modification:Translation factors:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 199 "Energy production and conversion:Dimethyladenosine transferase (rRNA methylation):Ribonucleotide reductase, alpha subunit:Metal-dependent proteases with possible chaperone activity:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:ADP-heptose:LPS heptosyltransferase:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Chromosome segregation ATPases:Uncharacterized distant relative of homeotic protein bithoraxoid:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized conserved protein:Predicted restriction endonuclease:Predicted methyltransferase (contains TPR repeat):Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Purine metabolism:Pyrimidine metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:gcp_kae1:ksgA:SMC_prok_B:PorC_KorC:NrdJ_Z:Defense mechanisms:Protein fate:tRNA and rRNA base modification:Protein synthesis:Chromosome-associated proteins:DNA metabolism:2'-Deoxyribonucleotide metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Nucleotide Metabolism:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Degradation of proteins, peptides, and glycopeptides" 200 "Molecular chaperone (small heat shock protein):Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis:tRNA-(guanine-N1)-methyltransferase:DNA primase (bacterial type):Signal recognition particle GTPase:Cytosine/adenosine deaminases:Exopolyphosphatase-related proteins:Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily:Cell division protein FtsI/penicillin-binding protein 2:UDP-N-acetylmuramyl tripeptide synthase:FOG: CheY-like receiver:RimM protein, required for 16S rRNA processing:NAD-dependent protein deacetylases, SIR2 family:Cell division septal protein:Pyridoxal phosphate biosynthesis protein:Uncharacterized protein conserved in bacteria:Predicted membrane protein:Signal transduction histidine kinase, nitrogen specific:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Lysine biosynthesis:Peptidoglycan biosynthesis:Vitamin B6 metabolism:Nitrogen metabolism:Metabolic pathways:Two-component system:DNA replication:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00006:trmD:sensory_box:pdxA:ffh:murE:dnaG:ftsL_broad:16S_RimM:NeuD_NnaD:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Energy Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Transcription:RNA processing:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Cell division:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridoxine:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 201 "Predicted ATPase of the PP-loop superfamily implicated in cell cycle control:Glucan phosphorylase:Cytidylate kinase:Fe2+ transport system protein B:Glycosyltransferases involved in cell wall biogenesis:GMP synthase, PP-ATPase domain/subunit:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:FOG: CheY-like receiver:Hydrolases of the alpha/beta superfamily:UDP-glucose 4-epimerase:16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases:Mn-dependent transcriptional regulator:Beta-lactamase class C and other penicillin binding proteins:Molybdopterin-guanine dinucleotide biosynthesis protein:Predicted transcriptional regulator:Molybdenum cofactor biosynthesis enzyme:Predicted permeases:Type II secretory pathway, component ExeA (predicted ATPase):Response regulator containing a CheY-like receiver domain and a GGDEF domain:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Galactose metabolism:Purine metabolism:Pyrimidine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Two-component system:Sulfur relay system:General function prediction only:Signal transduction mechanisms:cmk:TIGR00093:mobB:small_GTP:GGDEF:rarD:rrf2_super:guaA_Cterm:galE:cztR_silR_copR:P_ylase:moaA:TIGR03987:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Transport and binding proteins:tRNA and rRNA base modification:Protein synthesis:Purine ribonucleotide biosynthesis:Nucleotide and nucleoside interconversions:Purines, pyrimidines, nucleosides, and nucleotides:Sugars:Biosynthesis and degradation of polysaccharides:Energy metabolism:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Nucleotide Metabolism:General:Carbohydrate Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Molybdopterin:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Unknown function:Unknown substrate" 202 "Energy production and conversion:Ammonia permease:Glutamate synthase domain 1:Glutamate synthase domain 2:Glutamate synthase domain 3:Uncharacterized NAD(FAD)-dependent dehydrogenases:ATPases involved in chromosome partitioning:Multimeric flavodoxin WrbA:Fe2+/Zn2+ uptake regulation proteins:Arsenite efflux pump ACR3 and related permeases:ABC-type metal ion transport system, periplasmic component/surface adhesin:NifU homolog involved in Fe-S cluster formation:Predicted DNA-binding proteins:Predicted metal-dependent hydrolase:Uncharacterized protein conserved in bacteria:Predicted transcriptional regulators:Transposase and inactivated derivatives:Rhodanese-related sulfurtransferase:Uncharacterized protein conserved in bacteria:Inorganic pyrophosphatase:Predicted lipoprotein involved in nitrous oxide reduction:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Oxidative phosphorylation:ABC transporters:General function prediction only:Function unknown:V_PPase:Environmental Information Processing:Energy Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Cations and iron carrying compounds:Transport and binding proteins:Membrane Transport" 203 "ATP phosphoribosyltransferase:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase:Imidazoleglycerol-phosphate dehydratase:Histidinol dehydrogenase:Predicted amidohydrolase:2-methylthioadenine synthetase:Signal transduction histidine kinase:UDP-N-acetylglucosamine enolpyruvyl transferase:Glutamate racemase:Peroxiredoxin:Uncharacterized conserved protein:Cellulase M and related proteins:Methionine synthase I, cobalamin-binding domain:DnaK suppressor protein:Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB:Uncharacterized conserved protein:Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain):FOG: GGDEF domain:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Peptidylarginine deiminase and related enzymes:Signal transduction histidine kinase, nitrogen specific:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Cysteine and methionine metabolism:Arginine and proline metabolism:Histidine metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Selenocompound metabolism:D-Glutamine and D-glutamate metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Polycyclic aromatic hydrocarbon degradation:One carbon pool by folate:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00007:glut_race:hisD:hisG:TIGR00089:CoA_E_activ:GGDEF:rumA:murA:hisC:dksA:Poorly characterized:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Xenobiotics Biodegradation and Metabolism:Global:Metabolism:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA and rRNA base modification:Amino acid biosynthesis:Histidine family:Signal transduction:Other:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 204 "Energy production and conversion:Alanyl-tRNA synthetase:6-phosphofructokinase:Malic enzyme:Glycosyltransferase:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Signal recognition particle GTPase:rRNA methylases:Phosphopantetheine adenylyltransferase:Uncharacterized membrane protein (homolog of Drosophila rhomboid):FOG: CheY-like receiver:Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase:Multidrug resistance efflux pump:Transcriptional regulator/sugar kinase:Predicted ATPase (AAA+ superfamily):DNA uptake lipoprotein:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Galactose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Lipopolysaccharide biosynthesis:Pyruvate metabolism:Methane metabolism:Pantothenate and CoA biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Protein export:Bacterial secretion system:General function prediction only:Signal transduction mechanisms:ftsY:cyt_tran_rel:rRNA_methyl_3:alaS:lipid_A_lpxA:PFK_mixed:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 205 "Energy production and conversion:3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:Glucose-6-phosphate isomerase:Carbonic anhydrase:Hydrogenase maturation factor:Predicted methyltransferases:Predicted amidohydrolase:Signal transduction histidine kinase:Acetyl-CoA carboxylase beta subunit:NADH dehydrogenase, FAD-containing subunit:Predicted dioxygenase:Zn-dependent proteases:Uncharacterized conserved protein:Tfp pilus assembly protein, pilus retraction ATPase PilT:ABC-type uncharacterized transport system, periplasmic component:Cytochrome c2:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fatty acid biosynthesis:Ubiquinone and other terpenoid-quinone biosynthesis:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00096:TIGR00296:accD:pilT_fam:hypE:Nterm_to_SelD:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Unknown function:Carbohydrate Metabolism:Enzymes of unknown specificity:General:Cellular processes and signaling:Metabolism:Poorly characterized:Chemotaxis and motility:Cellular processes:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Global:Metabolism of Cofactors and Vitamins:Lipid Metabolism:Energy Metabolism" 206 "Energy production and conversion:Predicted divalent heavy-metal cations transporter:Zn-dependent hydrolases, including glyoxylases:Transcriptional regulator:Chemotaxis protein histidine kinase and related kinases:Methyl-accepting chemotaxis protein:Fe-S oxidoreductase:Transcriptional regulator:Outer membrane protein:Transcriptional regulators:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Aldehyde:ferredoxin oxidoreductase:Type IV secretory pathway, VirD4 components:Uncharacterized protein conserved in bacteria:ABC-type transport system, involved in lipoprotein release, permease component:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Cellular processes and signaling:Information storage and processing:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Carbohydrate Metabolism:Metabolism:Poorly characterized" 207 "Energy production and conversion:3-oxoacyl-[acyl-carrier-protein] synthase III:ATP-dependent Zn proteases:Arylsulfatase regulator (Fe-S oxidoreductase):Signal transduction histidine kinase:Bacterial cell division membrane protein:Apolipoprotein N-acyltransferase:Diacylglycerol kinase:Membrane protein TerC, possibly involved in tellurium resistance:Ferredoxin:Hemolysins and related proteins containing CBS domains:Predicted HD superfamily hydrolase:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized FAD-dependent dehydrogenases:Uncharacterized protein conserved in bacteria:Outer membrane protein/protective antigen OMA87:Cell cycle control, cell division, chromosome partitioning:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Metabolic pathways:General function prediction only:Function unknown:Signal transduction mechanisms:HDIG:TIGR00282:TIGR00296:mazG:YbgI_SA1388:lnt:fabH:FtsH_fam:rodA_shape:OM_YaeT:rSAM_more_4Fe4S:Cellular processes:Protein modification and repair:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking:Protein fate:Biosynthesis:Fatty acid and phospholipid metabolism:Metabolism:Metabolism:Global:Nucleotide Metabolism:Poorly characterized:Lipid Metabolism:Metabolism:Cellular processes and signaling:General:Enzymes of unknown specificity:Unknown function:Cell division" 208 "Energy production and conversion:Histidyl-tRNA synthetase:Nucleoside-diphosphate-sugar epimerases:Acetyltransferases:Na+/proline symporter:ABC-type branched-chain amino acid transport systems, periplasmic component:1-deoxy-D-xylulose 5-phosphate reductoisomerase:Nitroreductase:Transcription elongation factor:Predicted permeases:N-acetylmuramoyl-L-alanine amidase:Arginine decarboxylase (spermidine biosynthesis):Peroxiredoxin:Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins:Glutamine synthetase adenylyltransferase:Rubrerythrin:Rubredoxin:Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain:Holliday junction resolvasome, helicase subunit:Tfp pilus assembly protein, pilus retraction ATPase PilT:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Arginine and proline metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Homologous recombination:General function prediction only:Signal transduction mechanisms:sensory_box:Dxr:hisS:ruvB:speA:pilT_fam:rimI:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Amino Acid Metabolism:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Central intermediary metabolism:Polyamine biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Cellular processes:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 209 "Energy production and conversion:Adenylosuccinate lyase:Phenylalanyl-tRNA synthetase alpha subunit:Glutamine phosphoribosylpyrophosphate amidotransferase:Enolase:3-oxoacyl-(acyl-carrier-protein) synthase:(acyl-carrier-protein) S-malonyltransferase:3-oxoacyl-[acyl-carrier-protein] synthase III:NAD/FAD-utilizing enzyme apparently involved in cell division:Glycosyltransferases involved in cell wall biogenesis:Ribose 5-phosphate isomerase RpiB:UDP-glucose pyrophosphorylase:Cytochrome b subunit of formate dehydrogenase:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Pentose and glucuronate interconversions:Galactose metabolism:Fatty acid biosynthesis:Purine metabolism:Alanine aspartate and glutamate metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Methane metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:fabD:gidA:pheS:rpiB_lacA_lacB:fabH:purB:eno:galU:purF:fabF:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:tRNA and rRNA base modification:tRNA aminoacylation:Protein synthesis:Purine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Biosynthesis:Fatty acid and phospholipid metabolism:Glycolysis/gluconeogenesis:Energy metabolism:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Translation:Genetic Information Processing:Amino Acid Metabolism:Nucleotide Metabolism:Lipid Metabolism:Energy Metabolism:Carbohydrate Metabolism" 210 "Energy production and conversion:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type transport system involved in resistance to organic solvents, permease component:NAD-dependent aldehyde dehydrogenases:Outer membrane protein:Sec-independent protein secretion pathway components:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Uncharacterized conserved protein:Opacity protein and related surface antigens:Transcription:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Metabolic pathways:Microbial metabolism in diverse environments:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00056:tatB:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Carbohydrate Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein fate:Protein and peptide secretion and trafficking:Hypothetical proteins:Conserved:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 211 "Energy production and conversion:Fe-S-cluster-containing hydrogenase components 1:Signal transduction histidine kinase:Fe-S oxidoreductase:Multidrug resistance efflux pump:ABC-type Na+ efflux pump, permease component:Retron-type reverse transcriptase:Transposase and inactivated derivatives:Transposase and inactivated derivatives:Predicted membrane protein:Signal transduction histidine kinase:Replication, recombination and repair:Inorganic ion transport and metabolism:Function unknown:Signal transduction mechanisms:sensory_box:SAM_YgiQ:Defense mechanisms:Cellular processes and signaling:Information storage and processing:Enzymes of unknown specificity:Unknown function:Small molecule interactions:Regulatory functions:Metabolism:Poorly characterized" 212 "Energy production and conversion:Dephospho-CoA kinase:Fe-S oxidoreductase:Biotin-(acetyl-CoA carboxylase) ligase:DNA repair exonuclease:Carbamoylphosphate synthase small subunit:Uncharacterized conserved protein:Predicted Fe-S-cluster redox enzyme:Chemotaxis signal transduction protein:Recombinational DNA repair ATPase (RecF pathway):Organic solvent tolerance protein OstA:Uncharacterized protein conserved in bacteria:Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain):Predicted membrane protein:Predicted membrane protein:Uncharacterized conserved protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Pantothenate and CoA biosynthesis:Biotin metabolism:Metabolic pathways:Two-component system:Bacterial chemotaxis:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00048:tRNA_TruD_broad:birA_ligase:TIGR00152:CoA_E_activ:recf:CPSaseIIsmall:Metabolism:Cellular processes and signaling:Information storage and processing:Pantothenate and coenzyme A:Biosynthesis of cofactors, prosthetic groups, and carriers:Protein modification and repair:Protein fate:tRNA and rRNA base modification:Protein synthesis:DNA replication, recombination, and repair:DNA metabolism:Pyrimidine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Poorly characterized:Nucleotide Metabolism" 213 "Energy production and conversion:Predicted Co/Zn/Cd cation transporters:Nicotinate-nucleotide pyrophosphorylase:Protein chain release factor A:DNA repair exonuclease:Acylphosphatases:Acyl-CoA hydrolase:Uncharacterized conserved protein:Predicted N-acetylglucosaminyl transferase:Predicted permease:Tfp pilus assembly protein PilF:Uncharacterized protein conserved in bacteria:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell motility:Inorganic ion transport and metabolism:Pyruvate metabolism:Nicotinate and nicotinamide metabolism:Metabolic pathways:Microbial metabolism in diverse environments:General function prediction only:Function unknown:prfB:nadC:YidE_YbjL_dupl:Intracellular trafficking, secretion, and vesicular transport:Metabolism of Cofactors and Vitamins:Biosynthesis of cofactors, prosthetic groups, and carriers:Carbohydrate Metabolism:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Unknown substrate:Transport and binding proteins:Translation factors:Protein synthesis:Metabolism:Global" 214 "Energy production and conversion:3-phosphoglycerate kinase:Dihydrodipicolinate synthase/N-acetylneuraminate lyase:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Lipid A disaccharide synthetase:Cytochrome c biogenesis protein:Succinate dehydrogenase/fumarate reductase, flavoprotein subunit:Nicotinic acid mononucleotide adenylyltransferase:ABC-type multidrug transport system, ATPase and permease components:ABC-type antimicrobial peptide transport system, ATPase component:Heterodisulfide reductase, subunit A and related polyferredoxins:6Fe-6S prismane cluster-containing protein:N-acetylglutamate synthase (N-acetylornithine aminotransferase):Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Heterodisulfide reductase, subunit B:Uncharacterized conserved protein:Outer membrane protein/protective antigen OMA87:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Fructose and mannose metabolism:Oxidative phosphorylation:Lysine biosynthesis:Arginine and proline metabolism:Lipopolysaccharide biosynthesis:Inositol phosphate metabolism:Butanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Nicotinate and nicotinamide metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Function unknown:Signal transduction mechanisms:ArgJ:cyt_tran_rel:lpxB:sensory_box:TIGR00251:tim:dapA:hybrid_clust:sdhA_Bsu:MsbA_lipidA:tol_pal_ybgF:OM_YaeT:DivI1A_domain:Defense mechanisms:Cellular processes and signaling:Metabolism:Poorly characterized:Energy metabolism:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Energy Metabolism:Amino acids and amines:Carbohydrate Metabolism:Glycolysis/gluconeogenesis:TCA cycle:Regulatory functions:Small molecule interactions:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Other:Hypothetical proteins:Conserved:Amino acid biosynthesis:Aspartate family:Glutamate family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides" 215 "Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain:Phenylalanyl-tRNA synthetase beta subunit:Adenylosuccinate synthase:Aspartyl-tRNA synthetase:Orotate phosphoribosyltransferase:Signal transduction histidine kinase:Methylmalonyl-CoA mutase, N-terminal domain/subunit:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Transketolase, C-terminal subunit:Transketolase, N-terminal subunit:Predicted transcriptional regulator:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Pentose phosphate pathway:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Valine leucine and isoleucine degradation:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Signal transduction mechanisms:purA:pyrE:aspS_bact:pheT_bact:acid_CoA_mut_N:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:Protein synthesis:tRNA aminoacylation:Information storage and processing:Metabolism:Metabolism" 216 "Fe2+/Zn2+ uptake regulation proteins:FOG: CheY-like receiver:Predicted thioesterase:Methyl-accepting chemotaxis protein:Flagellin-specific chaperone FliS:Outer membrane protein:SOS-response transcriptional repressors (RecA-mediated autopeptidases):Nitrate/nitrite transporter:Permeases of the major facilitator superfamily:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase:Uncharacterized iron-regulated protein:Predicted enzyme related to lactoylglutathione lyase:Signal transduction histidine kinase, nitrogen specific:Virulence-associated protein and related proteins:Uncharacterized conserved protein:Amino acid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00051:fliS:sensory_box:lexA:DAHP_synth_Bsub:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Amino Acid Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:DNA interactions:Small molecule interactions:Cellular processes:Chemotaxis and motility:Unknown function:General:Amino acid biosynthesis:Aromatic amino acid family:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 217 "Glutamyl- and glutaminyl-tRNA synthetases:3-polyprenyl-4-hydroxybenzoate decarboxylase:ATPase components of ABC transporters with duplicated ATPase domains:Arylsulfatase regulator (Fe-S oxidoreductase):Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Uncharacterized flagellar protein FlaG:Predicted transcriptional regulator containing the HTH domain:FOG: LysM repeat:Outer membrane protein:Multidrug resistance efflux pump:Pyrimidine reductase, riboflavin biosynthesis:Flagellar biosynthesis pathway, component FliQ:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Ubiquinone and other terpenoid-quinone biosynthesis:Riboflavin metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Flagellar assembly:General function prediction only:ribD_Cterm:sensory_box:TIGR00281:ubiX_pad:TIGR00423:gltX_bact:fliQ:type_I_hlyD:rSAM_more_4Fe4S:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Unknown function:Enzymes of unknown specificity:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Chemotaxis and motility:Cellular processes:Protein and peptide secretion and trafficking:Protein fate:tRNA aminoacylation:Protein synthesis:Chromosome-associated proteins:DNA metabolism:Small molecule interactions:Metabolism:Metabolism:Global:Regulatory functions:Cell Motility:Cellular Processes:Translation:Genetic Information Processing:Hypothetical proteins:Metabolism of Cofactors and Vitamins:Conserved" 218 "Energy production and conversion:3-oxoacyl-(acyl-carrier-protein) synthase:Polyferredoxin:ATPase involved in DNA repair:Zn-dependent hydrolases, including glyoxylases:3-dehydroquinate dehydratase II:FOG: CheY-like receiver:Uncharacterized conserved protein:Subtilisin-like serine proteases:Exonuclease VII, large subunit:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Amino acid transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Phenylalanine tyrosine and tryptophan biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Bacterial secretion system:Mismatch repair:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:xseA:GGDEF:aroQ:B_ant_repeat:typeII_sec_gspL:Metabolism:Amino Acid Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:Degradation of DNA:Protein fate:Protein and peptide secretion and trafficking:Amino acid biosynthesis:Aromatic amino acid family:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 219 "Chorismate synthase:Phosphoribosyl-AMP cyclohydrolase:Dephospho-CoA kinase:Methylated DNA-protein cysteine methyltransferase:ABC-type branched-chain amino acid transport systems, ATPase component:DNA repair exonuclease:Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit:Predicted phosphatase/phosphohexomutase:Signal transduction histidine kinase:Shikimate kinase:Predicted transcriptional regulators:Putative periplasmic protein kinase ArgK and related GTPases of G3E family:Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding):Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Valine leucine and isoleucine degradation:Histidine metabolism:Benzoate degradation:Phenylalanine tyrosine and tryptophan biosynthesis:Starch and sucrose metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Pantothenate and CoA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Function unknown:Signal transduction mechanisms:aroC:TIGR00152:redox_disulf_2:ogt:acid_CoA_mut_C:lao:ahpD_dom:HAD-SF-IA-v3:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Regulatory functions:Carbohydrate Metabolism:Protein interactions:DNA metabolism:DNA replication, recombination, and repair:Unknown function:Enzymes of unknown specificity:General:Amino acid biosynthesis:Aromatic amino acid family:Biosynthesis of cofactors, prosthetic groups, and carriers:Pantothenate and coenzyme A" 220 "Energy production and conversion:Predicted Zn-dependent proteases and their inactivated homologs:FOG: TPR repeat:Carbamate kinase:Signal transduction histidine kinase:Methyl-accepting chemotaxis protein:Inorganic pyrophosphatase/exopolyphosphatase:Predicted signal transduction protein:Cytochrome c peroxidase:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:FOG: GGDEF domain:Serine phosphatase RsbU, regulator of sigma subunit:Cyclopropane fatty acid synthase and related methyltransferases:Predicted symporter:Amino acid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Arginine and proline metabolism:Benzoate degradation:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:General function prediction only:Signal transduction mechanisms:taut:GGDEF:HDIG:Na_symport_lg:Cellular processes and signaling:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Xenobiotics Biodegradation and Metabolism:Global:Metabolism:Energy metabolism:Other:Signal transduction:Other:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 221 "Energy production and conversion:ATPase involved in DNA repair:Glycosyltransferase:Biotin carboxylase:Zn-dependent hydrolases, including glyoxylases:Glycine cleavage system H protein (lipoate-binding):Shikimate kinase:3-dehydroquinate dehydratase II:FOG: CheY-like receiver:Fe-S oxidoreductase:Predicted periplasmic solute-binding protein:Coenzyme F390 synthetase:Deoxycytidylate deaminase:Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation):Response regulator containing a CheY-like receiver domain and a GGDEF domain:Predicted exporter:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Fatty acid biosynthesis:Pyrimidine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Pyruvate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:General function prediction only:Signal transduction mechanisms:sensory_box:GGDEF:accC:gcvH:aroQ:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Amino acids and amines:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:Amino acid biosynthesis:Aromatic amino acid family:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 222 "Energy production and conversion:Argininosuccinate lyase:Methylated DNA-protein cysteine methyltransferase:Predicted integral membrane protein:Exoribonuclease R:Chemotaxis protein histidine kinase and related kinases:Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Uncharacterized conserved protein:Predicted HD superfamily hydrolase:Acyl-CoA hydrolase:Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family:DNA uptake lipoprotein:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell motility:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Biosynthesis of unsaturated fatty acids:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:HDIG:3_prime_RNase:TIGR00374:ogt:argH:cztS_silS_copS:pepcterm_CAAX:Poorly characterized:Lipid Metabolism:Amino Acid Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Hypothetical proteins:Conserved:Amino acid biosynthesis:Glutamate family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 223 "Energy production and conversion:3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes:Predicted redox protein, regulator of disulfide bond formation:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:ABC-type sulfate transport system, permease component:Cystathionine beta-lyases/cystathionine gamma-synthases:ABC-type sulfate/molybdate transport systems, ATPase component:ABC-type sulfate transport system, periplasmic component:Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits:O-acetylhomoserine sulfhydrylase:GTPases - Sulfate adenylate transferase subunit 1:Uncharacterized protein conserved in bacteria:ABC-type sulfate transport system, permease component:Amino acid transport and metabolism:Coenzyme transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Cysteine and methionine metabolism:Selenocompound metabolism:Nitrogen metabolism:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Function unknown:small_GTP:3a0106s01:3a0106s02:3a0106s03:OAH_OAS_sulfhy:APS_reductase:Cellular processes and signaling:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Sulfur metabolism:Transport and binding proteins:Anions:Unknown function:General:Amino acid biosynthesis:Serine family:Metabolism:Metabolism:Poorly characterized" 224 "Energy production and conversion:Folylpolyglutamate synthase:Molybdopterin biosynthesis enzymes:ABC-type antimicrobial peptide transport system, permease component:Transcriptional regulator:Methionine synthase I (cobalamin-dependent), methyltransferase domain:Uncharacterized membrane protein (homolog of Drosophila rhomboid):ABC-type transport system involved in cytochrome c biogenesis, permease component:ABC-type amino acid transport system, permease component:FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:BioD-like N-terminal domain of phosphotransacetylase:Predicted glycosyltransferases:Coenzyme F420-reducing hydrogenase, gamma subunit:Formate/nitrite family of transporters:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Tfp pilus assembly protein PilF:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Coenzyme transport and metabolism:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Methane metabolism:Folate biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:General function prediction only:Signal transduction mechanisms:molyb_syn:GGDEF:folC:HEQRo_perm_3TM:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Poorly characterized:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Transport and binding proteins:Amino acids, peptides and amines:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 225 "Energy production and conversion:Acetyl-CoA hydrolase:Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Na+-driven multidrug efflux pump:Endonuclease IV:Predicted membrane metal-binding protein:Nitroreductase:FOG: CheY-like receiver:Cytochrome c biogenesis protein:Recombinational DNA repair protein (RecF pathway):Uracil-DNA glycosylase:Multisubunit Na+/H+ antiporter, MnhE subunit:Predicted metal-dependent hydrolase:Methylmalonyl-CoA mutase, N-terminal domain/subunit:Predicted membrane protein:Predicted membrane protein:Lipid transport and metabolism:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Oxidative phosphorylation:Valine leucine and isoleucine degradation:Propanoate metabolism:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Base excision repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:ComEC_N-term:nfo:reco:acid_CoA_mut_N:UDG_fam4:matE:Na_symport_sm:Defense mechanisms:Cellular processes and signaling:Information storage and processing:General:Unknown function:Other:Unknown substrate:Transport and binding proteins:DNA replication, recombination, and repair:DNA metabolism:Metabolism:Metabolism:Global:Replication and Repair:Genetic Information Processing:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Poorly characterized:Metabolism" 226 "Energy production and conversion:Mismatch repair ATPase (MutS family):Glycosyltransferase:NTP pyrophosphohydrolases including oxidative damage repair enzymes:ATPase involved in DNA replication initiation:Permeases of the drug/metabolite transporter (DMT) superfamily:Acylphosphatases:Flagellar basal body P-ring biosynthesis protein:DNA-binding protein, stimulates sugar fermentation:SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase:Uncharacterized conserved protein:Arabinose efflux permease:Predicted membrane protein:Bacterial lipocalin:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Purine metabolism:Pyruvate metabolism:Microbial metabolism in diverse environments:Two-component system:Flagellar assembly:Mismatch repair:General function prediction only:Function unknown:sfsA:rumA:efflux_EmrB:mutS1:flgA_cterm:Other:Carbohydrate Metabolism:Nucleotide Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:Other:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Metabolism:Cellular processes:Chemotaxis and motility:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 227 "Energy production and conversion:Glycine/serine hydroxymethyltransferase:Isopropylmalate/homocitrate/citramalate synthases:Predicted EndoIII-related endonuclease:Acyl carrier protein:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Predicted ATPase with chaperone activity:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase:Glycyl-tRNA synthetase, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Coenzyme F390 synthetase:TRAP-type C4-dicarboxylate transport system, large permease component:TRAP-type C4-dicarboxylate transport system, periplasmic component:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:TRAP-type C4-dicarboxylate transport system, small permease component:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Glycine serine and threonine metabolism:Valine leucine and isoleucine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Pyruvate metabolism:One carbon pool by folate:Methane metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Base excision repair:Secondary metabolites biosynthesis, transport and catabolism:aroFGH:glyS:TIGR00368:acyl_carrier:dctM:LeuA_rel:pyru_phos_dikin:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Energy metabolism:Other:Fatty acid and phospholipid metabolism:Biosynthesis:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Unknown function:General:Amino acid biosynthesis:Aromatic amino acid family:Information storage and processing:Cellular processes and signaling:Metabolism" 228 "Energy production and conversion:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Isoleucyl-tRNA synthetase:Ribosomal protein S20:Ribosomal protein L19:Uroporphyrinogen-III decarboxylase:Chaperonin GroEL (HSP60 family):Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit:Rhodanese-related sulfurtransferase:Single-stranded DNA-binding protein:Cell wall-associated hydrolases (invasion-associated proteins):ABC-type uncharacterized transport system, ATPase component:ABC-type (unclassified) transport system, ATPase component:DNA-directed RNA polymerase, subunit K/omega:Uncharacterized protein conserved in bacteria:4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase:Sporulation protein and related proteins:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Uncharacterized protein conserved in bacteria:Predicted signal transduction protein containing EAL and modified HD-GYP domains:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Valine leucine and isoleucine biosynthesis:Butanoate metabolism:C5-Branched dibasic acid metabolism:Carbon fixation pathways in prokaryotes:Pantothenate and CoA biosynthesis:Porphyrin and chlorophyll metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Ribosome:RNA degradation:RNA polymerase:DNA replication:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:S20:acolac_lg:ispE:ileS:rlpA:ssb:rpoZ:rplS_bact:hemE:sdhC_b558_fam:GroEL:SpoIID_LytB:Pal_lipo:outer_YhbN_LptA:exo_TIGR04073:Other:Heme, porphyrin, and cobalamin:Cell envelope:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism:Replication and Repair:Folding Sorting and Degradation:Translation:Transcription:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Nucleotide Metabolism:Energy Metabolism:Carbohydrate Metabolism:Energy metabolism:TCA cycle:DNA metabolism:DNA replication, recombination, and repair:Transcription:DNA-dependent RNA polymerase:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Protein fate:Protein folding and stabilization:Transport and binding proteins:Other:Unknown function:General:Amino acid biosynthesis:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers" 229 "Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:Exopolyphosphatase-related proteins:Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily:Cation/multidrug efflux pump:ABC-type multidrug transport system, ATPase and permease components:2'-5' RNA ligase:Transcriptional regulators:Uncharacterized protein conserved in bacteria:Surface lipoprotein:Starvation-inducible outer membrane lipoprotein:Predicted O-methyltransferase:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:General function prediction only:Function unknown:2_5_ligase:PEP_exosort:NeuD_NnaD:Defense mechanisms:Information storage and processing:Surface structures:Poorly characterized:RNA processing:Transcription:Cell envelope:Cellular processes and signaling" 230 "Energy production and conversion:Cell division GTPase:Ribosome recycling factor:Lactoylglutathione lyase and related lyases:F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit):NADPH:quinone reductase and related Zn-dependent oxidoreductases:Multimeric flavodoxin WrbA:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:Preprotein translocase subunit YidC:NAD-dependent aldehyde dehydrogenases:Zn-dependent alcohol dehydrogenases:Flagellar capping protein:Outer membrane protein:Transcriptional regulators:NADH:ubiquinone oxidoreductase 24 kD subunit:Uncharacterized anaerobic dehydrogenase:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Oxidative phosphorylation:Geraniol degradation:Pyruvate metabolism:Polycyclic aromatic hydrocarbon degradation:Naphthalene degradation:Limonene and pinene degradation:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Flagellar assembly:Protein export:Bacterial secretion system:General function prediction only:ftsZ:frr:ATP_synt_epsi:pyruv_ox_red:quinone_pig3:metmalonyl_epim:yidC_oxa1_cterm:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:ATP-proton motive force interconversion:Protein synthesis:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Cell division:Unknown function:Enzymes of unknown specificity:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 231 "Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase:AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful):Phosphoribosylamine-glycine ligase:ABC-type Co2+ transport system, permease component:Queuine/archaeosine tRNA-ribosyltransferase:Quinolinate synthase:Thiamine biosynthesis protein ThiC:Glycosyltransferases involved in cell wall biogenesis:Topoisomerase IA:ABC-type cobalt transport system, permease component CbiQ and related transporters:Selenophosphate synthase:Alanine racemase:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Putative periplasmic protein kinase ArgK and related GTPases of G3E family:Uncharacterized protein conserved in bacteria:4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family:Sec-independent protein secretion pathway components:ATP:corrinoid adenosyltransferase:Leucyl aminopeptidase (aminopeptidase T):Predicted N-acetylglucosaminyl transferase:Uncharacterized metal-binding protein:Predicted membrane protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Selenocompound metabolism:D-Alanine metabolism:One carbon pool by folate:Thiamine metabolism:Nicotinate and nicotinamide metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:Protein export:Bacterial secretion system:General function prediction only:Function unknown:thiC:purH:Q_tRNA_tgt:selD:alr:nadA:cobA:lao:purD:topA_bact:purE:tatAE:CbiQ_TIGR:tol_pal_ybgF:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Nucleotide Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Regulatory functions:Protein interactions:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Cations and iron carrying compounds:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Thiamine:Pyridine nucleotides:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 232 "ATPase components of ABC transporters with duplicated ATPase domains:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:ABC-type branched-chain amino acid transport systems, periplasmic component:Nucleoside phosphorylase:ADP-heptose:LPS heptosyltransferase:Ribosomal protein L11 methylase:3-methyladenine DNA glycosylase:Protein affecting phage T7 exclusion by the F plasmid:Uncharacterized protein related to capsule biosynthesis enzymes:Type I site-specific restriction-modification system, R (restriction) subunit and related helicases:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cysteine and methionine metabolism:Lipopolysaccharide biosynthesis:Metabolic pathways:Base excision repair:General function prediction only:prmA:tag:heptsyl_trn_III:Rhs_assc_core:Defense mechanisms:Information storage and processing:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Replication and Repair:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:Ribosomal proteins: synthesis and modification:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 233 "Energy production and conversion:Riboflavin synthase beta-chain:Pseudouridylate synthase:Aspartate-semialdehyde dehydrogenase:Geranylgeranyl pyrophosphate synthase:Orotidine-5'-phosphate decarboxylase:Prolyl-tRNA synthetase:RecA/RadA recombinase:Isocitrate/isopropylmalate dehydrogenase:Holliday junction resolvasome, endonuclease subunit:Tfp pilus assembly protein, pilus retraction ATPase PilT:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell motility:Pyrimidine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Lipopolysaccharide biosynthesis:Riboflavin metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Homologous recombination:Function unknown:hisT_truA:lumazine-synth:leuB:ruvC:proS_fam_II:pilT_fam:pyrF:asd_gamma:tigrfam_recA:Intracellular trafficking, secretion, and vesicular transport:Aspartate family:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Cellular processes:Chemotaxis and motility:Amino acid biosynthesis:Metabolism:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 234 "Mg2+ and Co2+ transporters:Predicted phosphatase/phosphohexomutase:Signal transduction histidine kinase:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Predicted SAM-dependent methyltransferases:Uncharacterized conserved protein:Highly conserved protein containing a thioredoxin domain:Transcriptional regulator of heat shock gene:Predicted signal transduction protein:Flagellar hook-basal body protein:Flagellar motor switch protein:Flagellar motor switch/type III secretory pathway protein:Uncharacterized MobA-related protein:Membrane transporters of cations and cationic drugs:Sugar phosphate permease:Uncharacterized protein conserved in bacteria:ABC-type phosphate/phosphonate transport system, periplasmic component:Transposase and inactivated derivatives:Predicted cobalamin binding protein:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:fliE:hrcA:corA:fliM_switch:HAD-SF-IA-v3:fliN:Intracellular trafficking, secretion, and vesicular transport:Unknown function:Chemotaxis and motility:Cellular processes:Cations and iron carrying compounds:Transport and binding proteins:DNA interactions:Regulatory functions:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Enzymes of unknown specificity" 235 "Energy production and conversion:3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases:Fe-S oxidoreductase:Predicted enzyme with a TIM-barrel fold:Peroxiredoxin:Signal transduction histidine kinase:FOG: CheY-like receiver:Predicted thioesterase:Methyl-accepting chemotaxis protein:Predicted hydrolase (HAD superfamily):Aspartate ammonia-lyase:NADH dehydrogenase, FAD-containing subunit:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Selenocysteine synthase [seryl-tRNASer selenium transferase]:Electron transfer flavoprotein, alpha subunit:Electron transfer flavoprotein, beta subunit:FOG: GGDEF domain:Hemerythrin:Predicted transcriptional regulator:Amino acid transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Alanine aspartate and glutamate metabolism:Selenocompound metabolism:Glycerophospholipid metabolism:Nitrogen metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00044:TIGR00051:TIGR00148:sensory_box:selA:C_GCAxxG_C_C:hemeryth_dom:dnstrm_HI1420:Cellular processes and signaling:Information storage and processing:General:Enzymes of unknown specificity:Unknown function:Other:Mobile and extrachromosomal element functions:tRNA aminoacylation:Protein synthesis:Small molecule interactions:Regulatory functions:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Lipid Metabolism:Poorly characterized:Energy Metabolism:Metabolism" 236 "Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:FOG: CheY-like receiver:ABC-type phosphate transport system, ATPase component:Uncharacterized membrane protein, required for colicin V production:Transglutaminase-like enzymes, putative cysteine proteases:Transcriptional regulator:Predicted transcriptional regulators:Ribonucleases G and E:Uncharacterized protein, possibly involved in motility:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase, nitrogen specific:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell motility:Inorganic ion transport and metabolism:ABC transporters:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:RNaseEG:3a0107s01c2:TAT_signal_seq:VI_zyme:Poorly characterized:Membrane Transport:Signal Transduction:Regulatory functions:Small molecule interactions:Transcription:Degradation of RNA:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Anions:Information storage and processing:Cellular processes and signaling:Metabolism:Environmental Information Processing" 237 "Energy production and conversion:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit:Acetate kinase:Aspartate/tyrosine/aromatic aminotransferase:Pyruvate kinase:Cation transport ATPase:2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes:ABC-type amino acid transport system, permease component:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Heme/copper-type cytochrome/quinol oxidases, subunit 1:Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Transcription:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Oxidative phosphorylation:Purine metabolism:Valine leucine and isoleucine biosynthesis:Lysine degradation:Tryptophan metabolism:Taurine and hypotaurine metabolism:Pyruvate metabolism:Propanoate metabolism:Butanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Signal transduction mechanisms:ackA:2oxo_dh_E1:pyruv_kin:ATPase_P-type:HEQRo_perm_3TM:GSu_C4xC__C2xCH:caa3_sub_IV:CtaD_CoxA:Fermentation:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Metabolism:Glycolysis/gluconeogenesis:TCA cycle:Transport and binding proteins:Amino acids, peptides and amines:Information storage and processing:Cellular processes and signaling:Metabolism" 238 "Energy production and conversion:Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase:Isoleucyl-tRNA synthetase:3-phosphoglycerate kinase:Co-chaperonin GroES (HSP10):Predicted membrane protein:Lipoprotein signal peptidase:Rhodanese-related sulfurtransferase:Formate hydrogenlyase subunit 4:Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit:Uncharacterized membrane protein (homolog of Drosophila rhomboid):FOG: CheY-like receiver:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Preprotein translocase subunit SecG:DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog:Ribosome-associated protein Y (PSrp-1):Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type):Growth inhibitor:Ni,Fe-hydrogenase III small subunit:Hydrogenase 4 membrane component (E):Signal transduction histidine kinase:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Fructose and mannose metabolism:Valine leucine and isoleucine biosynthesis:Glycerolipid metabolism:Inositol phosphate metabolism:Glycerophospholipid metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Phosphotransferase system (PTS):RNA polymerase:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00023:lspA:sensory_box:ileS:tim:yfiA:secG:GAPDH-I:rpoN_sigma:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Amino Acid Metabolism:Genetic Information Processing:Transcription:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Fatty acid and phospholipid metabolism:Biosynthesis:Regulatory functions:Small molecule interactions:Transcription:Transcription factors:Protein synthesis:tRNA aminoacylation:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 239 "Energy production and conversion:Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog):Predicted ATPase with chaperone activity:ABC-type dipeptide transport system, periplasmic component:Predicted hydrolase (HAD superfamily):Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Threonine dehydratase:Chromosome segregation ATPases:Uncharacterized distant relative of homeotic protein bithoraxoid:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Uncharacterized protein related to Endonuclease III:Uncharacterized Fe-S center protein:Predicted ATP-dependent Lon-type protease:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine biosynthesis:Carbon fixation pathways in prokaryotes:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:General function prediction only:Signal transduction mechanisms:gatB:TIGR00368:mazG:ilvA_1Cterm:SMC_prok_B:PorC_KorC:Lon_rel_chp:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:Chromosome-associated proteins:Protein synthesis:tRNA aminoacylation:Hypothetical proteins:Conserved:Unknown function:General:Amino acid biosynthesis:Pyruvate family:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 240 "Energy production and conversion:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit:Excinuclease ATPase subunit:Predicted Fe-S oxidoreductases:Mg2+ and Co2+ transporters:Alanine dehydrogenase:ABC-type amino acid transport/signal transduction systems, periplasmic component/domain:Pyruvate-formate lyase-activating enzyme:Archaeal S-adenosylmethionine synthetase:FOG: GAF domain:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon:Uncharacterized conserved protein:Amino acid transport and metabolism:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Taurine and hypotaurine metabolism:Selenocompound metabolism:Pyruvate metabolism:Butanoate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Nucleotide excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:corA:alaDH:uvra:rSAM_for_selen:Poorly characterized:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Amino acids and amines:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Cations and iron carrying compounds:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 241 "Energy production and conversion:Fe2+ transport system protein B:DNA polymerase III, alpha subunit:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Fe-S oxidoreductase:Methylase of chemotaxis methyl-accepting proteins:Chemotaxis protein; stimulates methylation of MCP proteins:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Carbohydrate-selective porin:Thiosulfate reductase cytochrome B subunit (membrane anchoring protein):Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Metabolic pathways:Two-component system:Bacterial chemotaxis:DNA replication:Mismatch repair:Homologous recombination:Signal transduction mechanisms:small_GTP:polc:paired_CXXCH_1:PEP_exosort:Information storage and processing:Nucleotide Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Unknown function:General:Cell envelope:Surface structures:Metabolism:Cellular processes and signaling:Metabolism" 242 "Nucleotidyltransferase/DNA polymerase involved in DNA repair:Deoxyribodipyrimidine photolyase:ATPase components of ABC transporters with duplicated ATPase domains:Flagellin and related hook-associated proteins:Flagellar basal body-associated protein:Predicted signal transduction protein:Flagellar basal body protein:SOS-response transcriptional repressors (RecA-mediated autopeptidases):Uncharacterized conserved protein:Transcription:Replication, recombination and repair:Cell motility:Two-component system:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:HDIG:lexA:phr2:FlgB:cas_GSU0054:Other:Signal Transduction:Cellular Processes:Cell Motility:Regulatory functions:DNA interactions:DNA metabolism:DNA replication, recombination, and repair:Cellular processes:Chemotaxis and motility:Mobile and extrachromosomal element functions:Environmental Information Processing:Information storage and processing:Cellular processes and signaling:Poorly characterized" 243 "Energy production and conversion:F0F1-type ATP synthase, beta subunit:Transaldolase:Citrate synthase:Nucleoside-diphosphate-sugar epimerases:NADPH-dependent glutamate synthase beta chain and related oxidoreductases:F0F1-type ATP synthase, subunit b:F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein):Bacterial nucleoid DNA-binding protein:NADH:ubiquinone oxidoreductase subunit 3 (chain A):NADH:ubiquinone oxidoreductase subunit 1 (chain H):Uncharacterized conserved protein:Transcriptional regulators:NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit:NADH:ubiquinone oxidoreductase 24 kD subunit:Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain:3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases:Uncharacterized anaerobic dehydrogenase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Citrate cycle (TCA cycle):Pentose phosphate pathway:Oxidative phosphorylation:Valine leucine and isoleucine degradation:Glyoxylate and dicarboxylate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:ttdA_fumA_fumB:fsa_talC_mipB:atpD:ATP_synt_delta:Carbohydrate Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Pentose phosphate pathway:ATP-proton motive force interconversion:Energy metabolism:Metabolism:Global:Amino Acid Metabolism:Energy Metabolism:Information storage and processing" 244 "Signal transduction histidine kinase:Cation/multidrug efflux pump:Membrane-fusion protein:Uncharacterized conserved protein:Transcriptional regulator:Predicted signal transduction protein:Flagellar motor switch protein:Sulfite oxidase and related enzymes:Membrane transporters of cations and cationic drugs:Serine phosphatase RsbU, regulator of sigma subunit:Cyclopropane fatty acid synthase and related methyltransferases:Predicted NAD/FAD-binding protein:Predicted membrane protein:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:fliM_switch:RND_mfp:cas3_GSU0051:Defense mechanisms:Cellular Processes:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Mobile and extrachromosomal element functions:Chemotaxis and motility:Cellular processes:Unknown substrate:Transport and binding proteins:Small molecule interactions:Regulatory functions:Cell Motility" 245 "Energy production and conversion:Riboflavin synthase alpha chain:Quinolinate synthase:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:F0F1-type ATP synthase, subunit b:Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis:Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains:Type II secretory pathway, component PulD:Sec-independent protein secretion pathway components:Phosphotransferase system, mannose/fructose-specific component IIA:ATP phosphoribosyltransferase involved in histidine biosynthesis:Transketolase, C-terminal subunit:Uncharacterized conserved protein:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Pentose phosphate pathway:Fructose and mannose metabolism:Oxidative phosphorylation:Histidine metabolism:Amino sugar and nucleotide sugar metabolism:Riboflavin metabolism:Nicotinate and nicotinamide metabolism:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Phosphotransferase system (PTS):Protein export:Bacterial secretion system:Function unknown:ribE:TIGR00244:hisZ_biosyn_reg:nadA:ispG_gcpE:tatAE:PTS_I_fam:type_II_gspD:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Global:Membrane Transport:Environmental Information Processing:Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Regulatory functions:Carbohydrate Metabolism:DNA interactions:Protein fate:Protein and peptide secretion and trafficking:Amino acid biosynthesis:Histidine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Riboflavin, FMN, and FAD:Pyridine nucleotides:Information storage and processing" 246 "ABC-type phosphate transport system, periplasmic component:ATP-dependent Lon protease, bacterial type:Superfamily II DNA and RNA helicases:ABC-type phosphate transport system, permease component:Signal transduction histidine kinase:Chemotaxis protein histidine kinase and related kinases:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Flagellar hook capping protein:FOG: GGDEF domain:Flagellar hook-length control protein:Signal transduction histidine kinase:ABC-type transport system, involved in lipoprotein release, permease component:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:RNA degradation:Signal transduction mechanisms:sensory_box:GGDEF:lon:ptsS_2:phosphate_pstC:Other:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Regulatory functions:Small molecule interactions:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Anions:Signal transduction:Genetic Information Processing:Information storage and processing:Cellular processes and signaling:Metabolism" 247 "Phosphoribosyl-ATP pyrophosphohydrolase:Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis:Glycosyltransferase:ATPases involved in chromosome partitioning:Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily:CMP-N-acetylneuraminic acid synthetase:dTDP-D-glucose 4,6-dehydratase:Glycosyltransferases, probably involved in cell wall biogenesis:Coenzyme F390 synthetase:Periplasmic protein involved in polysaccharide export:Sialic acid synthase:Sugar transferases involved in lipopolysaccharide synthesis:Uncharacterized conserved protein:Predicted N-acetylglucosaminyl transferase:Uncharacterized protein involved in exopolysaccharide biosynthesis:Type II secretory pathway, component ExeA (predicted ATPase):Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Cell wall/membrane/envelope biogenesis:Histidine metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Function unknown:eps_fam:8TM_EpsH:EpsI_fam:PEP_TPR_lipo:pepcterm_polyde:pepcterm_ChnLen:EpsB_2:pepcterm_ATPase:pepcterm_hypo_1:histidine_hisI:NeuD_NnaD:Intracellular trafficking, secretion, and vesicular transport:Amino acid biosynthesis:Carbohydrates, organic alcohols, and acids:Unknown substrate:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Metabolism:Metabolism:Global:Amino Acid Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:Histidine family" 248 "Thymidylate kinase:Xanthosine triphosphate pyrophosphatase:Pseudouridine synthase:Dethiobiotin synthetase:Geranylgeranyl pyrophosphate synthase:Ribosomal protein S15P/S13E:Transcription elongation factor:1-acyl-sn-glycerol-3-phosphate acyltransferase:Cysteinyl-tRNA synthetase:Ribosome recycling factor:Aspartate/tyrosine/aromatic aminotransferase:Translation initiation factor 2 (IF-2; GTPase):Predicted transcriptional regulators:Uncharacterized protein conserved in bacteria:Transcription elongation factor:Ribosome-binding factor A:Cytidylate kinase:Phosphatidylserine synthase:Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase):Cold shock proteins:Cobyrinic acid a,c-diamide synthase:Predicted nucleic-acid-binding protein implicated in transcription termination:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Thiamine metabolism:Biotin metabolism:Porphyrin and chlorophyll metabolism:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:RNA degradation:Function unknown:S21p:TIGR00042:rbfA:small_GTP:bioD:cobB:TruB:cysS:pssA:frr:S15_bact:greA:NusA:polynuc_phos:prismane_assoc:Biosynthesis of cofactors, prosthetic groups, and carriers:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Translation:Folding Sorting and Degradation:Global:Metabolism:Energy metabolism:Electron transport:Fatty acid and phospholipid metabolism:Biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Transcription factors:RNA processing:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:tRNA and rRNA base modification:Translation factors:Unknown function:General:Metabolism:Biotin:Heme, porphyrin, and cobalamin:Information storage and processing:Metabolism:Poorly characterized" 249 "Energy production and conversion:Dimethyladenosine transferase (rRNA methylation):Phosphoribosylaminoimidazole (AIR) synthetase:5-formyltetrahydrofolate cyclo-ligase:Glycosyltransferase:Carbamoylphosphate synthase large subunit (split gene in MJ):ATPase components of ABC transporters with duplicated ATPase domains:Selenocysteine lyase:Metal-dependent proteases with possible chaperone activity:Actin-like ATPase involved in cell division:Fe-S oxidoreductase:Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase:Uncharacterized protein predicted to be involved in DNA repair:Predicted ATPase related to phosphate starvation-inducible protein PhoH:Protein involved in cell division:Truncated, possibly inactive, lysyl-tRNA synthetase (class II):K+ transporter:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Lipopolysaccharide biosynthesis:One carbon pool by folate:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Signal transduction mechanisms:sensory_box:cas1:gcp_kae1:genX:ksgA:purM:ftsA:CPSaseII_lrg:lipid_A_lpxA:cas_CT1978:am_tr_V_EF2568:mob_myst_A:mob_myst_B:MTHFS_bact:Information storage and processing:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Global:Metabolism:Central intermediary metabolism:One-carbon metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Pyrimidine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:Protein synthesis:tRNA and rRNA base modification:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cellular processes:Cell division:Mobile and extrachromosomal element functions:Other:Unknown function:Enzymes of unknown specificity:General:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 250 "Glycosyltransferase:Phage protein D:Uncharacterized conserved protein:Cell wall/membrane/envelope biogenesis:General function prediction only:Function unknown:TIGR02241:tail_TIGR02242:TIGR02243:Poorly characterized:Cellular processes and signaling:Prophage functions:Mobile and extrachromosomal element functions" 251 "Energy production and conversion:Fe-S oxidoreductase:Predicted nucleoside-diphosphate-sugar epimerases:FOG: CheY-like receiver:Membrane-fusion protein:Predicted hydrolase (HAD superfamily):Predicted SAM-dependent methyltransferases:Cytidylate kinase:Predicted inhibitor of MCP methylation, homolog of CheC:NCAIR mutase (PurE)-related proteins:Electron transfer flavoprotein, alpha subunit:Uncharacterized conserved protein:ABC-type molybdate transport system, ATPase component:Uncharacterized conserved protein:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:ABC transporters:General function prediction only:Function unknown:Signal transduction mechanisms:RND_mfp:modC_ABC:Membrane Transport:Environmental Information Processing:Poorly characterized:Metabolism:Cellular processes and signaling:Anions:Unknown substrate:Transport and binding proteins" 252 "Energy production and conversion:Polyferredoxin:Glycosidases:Fe-S-cluster-containing hydrogenase components 1:Glycerol kinase:Rhodanese-related sulfurtransferase:Permeases of the drug/metabolite transporter (DMT) superfamily:Mismatch repair ATPase (MutS family):Ni,Fe-hydrogenase I small subunit:K+-transporting ATPase, A chain:Starvation-inducible outer membrane lipoprotein:Signal transduction histidine kinase, nitrogen specific:Predicted O-methyltransferase:Signal transduction histidine kinase:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Glycerolipid metabolism:Metabolic pathways:Two-component system:Mismatch repair:General function prediction only:Signal transduction mechanisms:sensory_box:hydA:kdpA:mutS2:glycerol_kin:Cations and iron carrying compounds:Lipid Metabolism:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Electron transport:Other:Regulatory functions:Small molecule interactions:DNA metabolism:Other:Transport and binding proteins:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 253 "Energy production and conversion:Uncharacterized conserved protein:Site-specific DNA methylase:Glutaredoxin and related proteins:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Hemolysins and related proteins containing CBS domains:Uncharacterized conserved protein:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:GTPases:Uncharacterized protein conserved in bacteria:Predicted ATPase:Cytochrome c2:Transposase and inactivated derivatives:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Cysteine and methionine metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00106:sensory_box:GlrX_YruB:CxxC_CxxC_SSSS:GTP_HflX:tRNA_sel_U_synt:Metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Small molecule interactions:Amino Acid Metabolism:Protein synthesis:tRNA and rRNA base modification:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:DNA interactions:Regulatory functions" 254 "Energy production and conversion:Glycerol-3-phosphate dehydrogenase:Glycosyltransferase:Predicted glycosyltransferases:Transposase and inactivated derivatives:Sugar transferases involved in lipopolysaccharide synthesis:Type II secretory pathway, pseudopilin PulG:Tfp pilus assembly protein, ATPase PilM:Protein involved in cellulose biosynthesis (CelD):Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Glycerophospholipid metabolism:Bacterial secretion system:General function prediction only:fkbM_fam:IV_pilin_GFxxxE:EPS_sugtrans:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Lipid Metabolism:Environmental Information Processing:Membrane Transport:Protein fate:Protein and peptide secretion and trafficking:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 255 "Energy production and conversion:Phosphoribosyl-AMP cyclohydrolase:ABC-type branched-chain amino acid transport systems, ATPase component:ABC-type branched-chain amino acid transport systems, ATPase component:Branched-chain amino acid ABC-type transport system, permease components:ABC-type branched-chain amino acid transport systems, periplasmic component:Coenzyme F390 synthetase:ABC-type branched-chain amino acid transport system, permease component:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:ACT domain-containing protein:Amino acid transport and metabolism:Coenzyme transport and metabolism:Histidine metabolism:Phenylalanine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:General function prediction only:IOR_alpha:Poorly characterized:Amino Acid Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Metabolism:Metabolism" 256 "Energy production and conversion:Ornithine carbamoyltransferase:Molybdopterin biosynthesis enzyme:Molybdenum cofactor biosynthesis enzyme:Membrane protease subunits, stomatin/prohibitin homologs:Pyruvate kinase:Predicted GTPase:NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K):NADH:ubiquinone oxidoreductase subunit 6 (chain J):NADH:ubiquinone oxidoreductase subunit 1 (chain H):NADH:ubiquinone oxidoreductase subunit 4 (chain M):Aconitase A:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit:Phosphomannomutase:ABC-type Mn/Zn transport systems, ATPase component:Peroxiredoxin:NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit:NADH:flavin oxidoreductases, Old Yellow Enzyme family:NADH:ubiquinone oxidoreductase 24 kD subunit:Predicted metal-dependent enzyme:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Fructose and mannose metabolism:Oxidative phosphorylation:Purine metabolism:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Butanoate metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Sulfur relay system:General function prediction only:molyb_syn:moaC:orni_carb_tr:pyruv_kin:acon_putative:GSu_C4xC__C2xCH:NDH_I_M:Obg_CgtA:PDH_E1_alph_y:Molybdopterin:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Energy metabolism:Electron transport:Glycolysis/gluconeogenesis:Pyruvate dehydrogenase:TCA cycle:Protein synthesis:Other:Amino acid biosynthesis:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 257 "Energy production and conversion:Polyprenyltransferase (cytochrome oxidase assembly factor):Nucleoside-diphosphate-sugar epimerases:Predicted Fe-S oxidoreductases:NADPH:quinone reductase and related Zn-dependent oxidoreductases:Signal transduction histidine kinase:Predicted oxidoreductases (related to aryl-alcohol dehydrogenases):Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Uncharacterized Fe-S protein:Heme/copper-type cytochrome/quinol oxidases, subunit 2:Uncharacterized conserved protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:High-affinity K+ transport system, ATPase chain B:Predicted Zn-dependent hydrolases of the beta-lactamase fold:Permeases of the major facilitator superfamily:Predicted GTPase:Arabinose efflux permease:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Carbohydrate transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:ATPase_P-type:oxido_YhdH:CoxB:rSAM_more_4Fe4S:Poorly characterized:Energy Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Global:Metabolism:Energy metabolism:Electron transport:Regulatory functions:Small molecule interactions:Unknown function:Enzymes of unknown specificity:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 258 "Energy production and conversion:Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit:Cysteine synthase:Predicted N6-adenine-specific DNA methylase:Argininosuccinate synthase:Ribosomal protein L27:Conserved domain frequently associated with peptide methionine sulfoxide reductase:Uncharacterized flavoproteins:Ribosomal protein S1:Membrane-fusion protein:Predicted alternative thymidylate synthase:Protein-disulfide isomerase:Exonuclease VII small subunit:Uncharacterized conserved protein, contains double-stranded beta-helix domain:FOG: GGDEF domain:FOG: GAF domain:Outer membrane protein and related peptidoglycan-associated (lipo)proteins:Amino acid transport and metabolism:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Valine leucine and isoleucine biosynthesis:Arginine and proline metabolism:Selenocompound metabolism:Pyruvate metabolism:Butanoate metabolism:One carbon pool by folate:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Ribosome:Mismatch repair:Function unknown:Signal transduction mechanisms:argG:L27:sensory_box:TIGR00357:rpsA:cysKM:xseB:RND_mfp:thyX:TIGR02243:Pal_lipo:Mobile and extrachromosomal element functions:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Signal Transduction:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:2'-Deoxyribonucleotide metabolism:Regulatory functions:Small molecule interactions:DNA metabolism:Degradation of DNA:Protein synthesis:Ribosomal proteins: synthesis and modification:Transport and binding proteins:Unknown substrate:Cellular processes:Adaptations to atypical conditions:Metabolism:Prophage functions:Amino acid biosynthesis:Glutamate family:Serine family:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 259 "Energy production and conversion:ABC-type antimicrobial peptide transport system, ATPase component:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Flagellar hook protein FlgE:Uncharacterized protein conserved in bacteria:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Hemerythrin:Transcription:Cell motility:Inorganic ion transport and metabolism:Flagellar assembly:Function unknown:Signal transduction mechanisms:MerA:flagell_FliJ:hemeryth_dom:flg_new:FlgEFG_subfam:Defense mechanisms:Poorly characterized:Cell Motility:Cellular processes:Detoxification:Chemotaxis and motility:Information storage and processing:Cellular processes and signaling:Metabolism:Cellular Processes" 260 "Uracil phosphoribosyltransferase:Predicted sugar kinase:Uncharacterized conserved protein:tRNA delta(2)-isopentenylpyrophosphate transferase:ATPase involved in DNA replication initiation:Polyphosphate kinase:Predicted GTPases:Uncharacterized conserved protein:Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain):Transposase and inactivated derivatives:Homocysteine/selenocysteine methylase (S-methylmethionine-dependent):FOG: GAF domain:Holliday junction resolvasome, helicase subunit:Plasmid stabilization system protein:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Inorganic ion transport and metabolism:Oxidative phosphorylation:Pyrimidine metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:RNA degradation:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00159:miaA:yjeF_cterm:small_GTP:ruvB:TIGR01033:upp:cysG_Nterm:poly_P_kin:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Global:Signal Transduction:Environmental Information Processing:Replication and Repair:Metabolism:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Central intermediary metabolism:Energy Metabolism:Phosphorus compounds:Purines, pyrimidines, nucleosides, and nucleotides:Salvage of nucleosides and nucleotides:Regulatory functions:DNA interactions:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Hypothetical proteins:Conserved:Unknown function" 261 "Energy production and conversion:Cation transport ATPase:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:Pseudouridylate synthases, 23S RNA-specific:Predicted amidophosphoribosyltransferases:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs:Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs:FOG: GGDEF domain:Uncharacterized conserved protein:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Translation, ribosomal structure and biogenesis:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Pyruvate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:rluA_subfam:GGDEF:lipoamide_DH:TAT_signal_seq:ATPase_P-type:poly_P_AMP_trns:Cellular processes and signaling:Carbohydrate Metabolism:Amino Acid Metabolism:Global:Metabolism:Central intermediary metabolism:Phosphorus compounds:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Signal transduction:Other:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 262 "Methionyl-tRNA synthetase:Sulfite reductase, beta subunit (hemoprotein):Predicted metal-dependent hydrolase:Thiamine biosynthesis protein ThiC:Nucleoside-diphosphate-sugar epimerases:IMP dehydrogenase/GMP reductase:Ribosomal protein S1:dsRNA-specific ribonuclease:ABC-type transport system involved in cytochrome c biogenesis, permease component:Lipid A disaccharide synthetase:Acetyl-CoA carboxylase beta subunit:Apolipoprotein N-acyltransferase:GDP-D-mannose dehydratase:GTPase:Transcription-repair coupling factor (superfamily II helicase):Hemolysins and related proteins containing CBS domains:ResB protein required for cytochrome c biosynthesis:Uncharacterized homolog of PSP1:Predicted transcriptional regulator:Uncharacterized distant relative of homeotic protein bithoraxoid:Uncharacterized FAD-dependent dehydrogenases:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fructose and mannose metabolism:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Selenocompound metabolism:Amino sugar and nucleotide sugar metabolism:Lipopolysaccharide biosynthesis:Pyruvate metabolism:Propanoate metabolism:Carbon fixation pathways in prokaryotes:Thiamine metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:RNA polymerase:Nucleotide excision repair:General function prediction only:Function unknown:TIGR00043:thiC:lpxB:small_GTP:metG:accD:lnt:mfd:rpsA:rrf2_super:IMP_dehydrog:gmd:paired_CXXCH_1:rpoB:RNaseIII:List_Bact_rpt:cytochr_II_ccsB:Thiamine:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Transcription:Translation:Replication and Repair:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Transcription:DNA-dependent RNA polymerase:RNA processing:Protein synthesis:Other:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Protein fate:Protein modification and repair:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 263 "Energy production and conversion:Aspartate oxidase:Tyrosyl-tRNA synthetase:Aspartyl-tRNA synthetase:Tryptophanyl-tRNA synthetase:Porphobilinogen deaminase:S-adenosylmethionine synthetase:Predicted S-adenosylmethionine-dependent methyltransferase:Aspartate/tyrosine/aromatic aminotransferase:Homoserine dehydrogenase:Thioredoxin reductase:Transcription termination factor:Fe-S oxidoreductase:Lysyl-tRNA synthetase (class II):Type II secretory pathway, component PulF:Serine kinase of the HPr protein, regulates carbohydrate metabolism:Predicted P-loop-containing kinase:3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase:ABC-type transport system, involved in lipoprotein release, permease component:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Tryptophan metabolism:Selenocompound metabolism:Lipopolysaccharide biosynthesis:Nicotinate and nicotinamide metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Bacterial secretion system:General function prediction only:Signal transduction mechanisms:TIGR00091:hemC:trpS:tyrS:aspS_bact:lysS_bact:nadB:hpr-ser:metK:TRX_reduct:KDO8P_synth:nusB:GspF:lolCE:HpnJ:DAPAT_plant:Intracellular trafficking, secretion, and vesicular transport:Signal transduction:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Other:Energy metabolism:Electron transport:Transcription:Transcription factors:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Pyridine nucleotides:Metabolism:PTS:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 264 "Energy production and conversion:Cell division GTPase:Peroxiredoxin:UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase:Universal stress protein UspA and related nucleotide-binding proteins:Signal transduction histidine kinase:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase:UDP-N-acetylmuramoylalanine-D-glutamate ligase:Bacterial cell division membrane protein:UDP-N-acetylmuramate-alanine ligase:UDP-N-acetylmuramate dehydrogenase:Fe-S oxidoreductase:D-alanine-D-alanine ligase and related ATP-grasp enzymes:Cytochrome bd-type quinol oxidase, subunit 1:Cytochrome bd-type quinol oxidase, subunit 2:Phosphate transport regulator (distant homolog of PhoU):Uncharacterized protein required for formate dehydrogenase activity:Uncharacterized conserved protein:Cell division septal protein:Predicted transcriptional regulator:Uncharacterized distant relative of homeotic protein bithoraxoid:Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases:Starvation-inducible outer membrane lipoprotein:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Cell cycle control, cell division, chromosome partitioning:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:D-Glutamine and D-glutamate metabolism:D-Alanine metabolism:Amino sugar and nucleotide sugar metabolism:Peptidoglycan biosynthesis:Metabolic pathways:General function prediction only:Function unknown:Signal transduction mechanisms:ftsZ:fdhD_narQ:murB:cydB:sensory_box:mraY:rrf2_super:murC:murD:murG:D_ala_D_alaTIGR:PEP_exosort:ftsW:sam_1_link_chp:Unknown function:Cell division:Cellular processes:Small molecule interactions:Regulatory functions:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Glycan Biosynthesis and Metabolism:Metabolism of Other Amino Acids:Energy Metabolism:Poorly characterized:Carbohydrate Metabolism:Metabolism:Cellular processes and signaling:Information storage and processing:Surface structures:Biosynthesis and degradation of murein sacculus and peptidoglycan:Cell envelope:General" 265 "Energy production and conversion:5-formyltetrahydrofolate cyclo-ligase:Exopolyphosphatase:Formate hydrogenlyase subunit 4:Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit:Bacterial nucleoid DNA-binding protein:Actin-like ATPase involved in cell division:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria):Co/Zn/Cd efflux system component:Amidases related to nicotinamidase:Precorrin isomerase:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Growth inhibitor:Ni,Fe-hydrogenase III large subunit:Signal transduction histidine kinase, nitrogen specific:Hydrogenase 4 membrane component (E):Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Inorganic ion transport and metabolism:Purine metabolism:One carbon pool by folate:Porphyrin and chlorophyll metabolism:Metabolic pathways:Two-component system:Phosphotransferase system (PTS):Secondary metabolites biosynthesis, transport and catabolism:Signal transduction mechanisms:sensory_box:ftsA:CDF:PTS_I_fam:MTHFS_bact:Information storage and processing:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Central intermediary metabolism:One-carbon metabolism:Regulatory functions:Small molecule interactions:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Cell division:Metabolism:Cellular processes and signaling:Metabolism" 266 "Energy production and conversion:Excinuclease ATPase subunit:Exopolyphosphatase:Polyferredoxin:Uroporphyrinogen-III decarboxylase:Molecular chaperone GrpE (heat shock protein):Coproporphyrinogen III oxidase and related Fe-S oxidoreductases:Chemotaxis protein histidine kinase and related kinases:Biopolymer transport proteins:Biopolymer transport protein:Rad3-related DNA helicases:Predicted membrane protein:Exonuclease V gamma subunit:Predicted signal transduction protein:Ni,Fe-hydrogenase I cytochrome b subunit:Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems:Cobalamin biosynthesis protein CbiG:Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases:NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding:Protein affecting phage T7 exclusion by the F plasmid:Transposase and inactivated derivatives:Response regulator containing a CheY-like receiver domain and a GGDEF domain:ABC-type transport system, involved in lipoprotein release, permease component:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Nicotinate and nicotinamide metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:Bacterial chemotaxis:Nucleotide excision repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:hemN_rel:uvra:yihY_not_rbn:recC:CytB-hydogenase:tolQ:tolR:Intracellular trafficking, secretion, and vesicular transport:Small molecule interactions:Regulatory functions:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Metabolism:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism:Nucleotide Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Unknown function:Pathogenesis:Cellular processes:DNA replication, recombination, and repair:DNA metabolism" 267 "Ribosomal protein L13:Ribosomal protein S9:Guanylate kinase:Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis:Ribosomal protein L19:DNA primase (bacterial type):Phosphatidylglycerophosphate synthase:DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):Uncharacterized conserved protein:Cell division protein FtsI/penicillin-binding protein 2:UDP-N-acetylmuramyl tripeptide synthase:Predicted metal-binding, possibly nucleic acid-binding protein:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Tfp pilus assembly protein PilF:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Purine metabolism:Lysine biosynthesis:Peptidoglycan biosynthesis:Glycerophospholipid metabolism:Metabolic pathways:Ribosome:RNA polymerase:DNA replication:General function prediction only:Function unknown:TIGR00006:TIGR00278:pgsA:rplS_bact:rplM_bact:murE:dnaG:RpoD_Cterm:guanyl_kin:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Transcription:Translation:Replication and Repair:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:DNA metabolism:DNA replication, recombination, and repair:Transcription:Transcription factors:Protein synthesis:Ribosomal proteins: synthesis and modification:Hypothetical proteins:Conserved:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 268 "Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon):Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor):Coenzyme F390 synthetase:Sugar transferases involved in lipopolysaccharide synthesis:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Transposase and inactivated derivatives:Signal transduction histidine kinase, nitrogen specific:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Two-component system:Signal transduction mechanisms:ant_ant_sig:PEP_exosort:EpsB_2:Metabolism:Signal Transduction:Regulatory functions:Protein interactions:Cell envelope:Surface structures:Information storage and processing:Cellular processes and signaling:Environmental Information Processing" 269 "Nucleotidyltransferase/DNA polymerase involved in DNA repair:ABC-type transport system involved in cytochrome c biogenesis, permease component:Methyl-accepting chemotaxis protein:Lysine efflux permease:4-alpha-glucanotransferase:Cytotoxic translational repressor of toxin-antitoxin stability system:Antitoxin of toxin-antitoxin stability system:FOG: GAF domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:HD-GYP domain:CO dehydrogenase maturation factor:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Signal transduction histidine kinase, nitrogen specific:Signal transduction histidine kinase:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Starch and sucrose metabolism:Metabolic pathways:Two-component system:Bacterial chemotaxis:General function prediction only:Signal transduction mechanisms:malQ:sensory_box:HDIG:phd_fam:paired_CXXCH_1:RelE_StbE:Cellular processes and signaling:Carbohydrate Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Regulatory functions:Small molecule interactions:Mobile and extrachromosomal element functions:Other:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 270 "Energy production and conversion:Carbonic anhydrase:Fe-S-cluster-containing hydrogenase components 1:Peroxiredoxin:Transcriptional regulator:Multidrug resistance efflux pump:Squalene cyclase:Uncharacterized protein with SCP/PR1 domains:Uncharacterized conserved protein:Lipid transport and metabolism:Transcription:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Nitrogen metabolism:Biosynthesis of secondary metabolites:Function unknown:hopene_cyclase:SAM_7_link_chp:selen_ocin:Defense mechanisms:Information storage and processing:Energy Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Other:Fatty acid and phospholipid metabolism:Metabolism:Global" 271 "Predicted transcriptional regulators:Flagellar hook-associated protein:Flagellin and related hook-associated proteins:Carbon storage regulator (could also regulate swarming and quorum sensing):Uncharacterized protein conserved in bacteria:Flagellar hook protein FlgE:Flagellar hook capping protein:Flagellar hook-length control protein:Transcription:Cell motility:Two-component system:Flagellar assembly:Function unknown:Signal transduction mechanisms:csrA:flgK_ends:flg_new:flagell_flgL:FlgEFG_subfam:Information storage and processing:Signal Transduction:Cellular Processes:Cell Motility:Regulatory functions:RNA interactions:Cellular processes:Chemotaxis and motility:Environmental Information Processing:Cellular processes and signaling:Poorly characterized" 272 "Energy production and conversion:Fe-S oxidoreductase:FAD/FMN-containing dehydrogenases:Glycosyltransferase:Transcriptional regulator:Methyl-accepting chemotaxis protein:ADP-heptose:LPS heptosyltransferase:ABC-type antimicrobial peptide transport system, ATPase component:Uncharacterized conserved protein containing a ferredoxin-like domain:Metal-dependent hydrolases of the beta-lactamase superfamily III:Amidases related to nicotinamidase:L-lactate permease:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Uncharacterized conserved protein:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Signal transduction histidine kinase:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Glyoxylate and dicarboxylate metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Information storage and processing:Small molecule interactions:Regulatory functions:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Carbohydrate Metabolism:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling" 273 "Energy production and conversion:3-oxoacyl-[acyl-carrier-protein] synthase III:Ni,Fe-hydrogenase I large subunit:Fe-S-cluster-containing hydrogenase components 1:FOG: Ankyrin repeat:Ni,Fe-hydrogenase maturation factor:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase:Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain:DnaK suppressor protein:Ni,Fe-hydrogenase I small subunit:Uncharacterized protein conserved in bacteria:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Fatty acid biosynthesis:Nitrotoluene degradation:Folate biosynthesis:Metabolic pathways:Microbial metabolism in diverse environments:General function prediction only:Function unknown:Signal transduction mechanisms:hydrog_prot:hydA:fabH:TAT_signal_seq:folK:dksA:Cellular processes and signaling:Metabolism:Poorly characterized:Protein fate:Small molecule interactions:Regulatory functions:Biosynthesis:Fatty acid and phospholipid metabolism:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Protein and peptide secretion and trafficking:Lipid Metabolism:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Information storage and processing" 274 "Exonuclease III:Bacterial nucleoid DNA-binding protein:BioD-like N-terminal domain of phosphotransacetylase:Antitoxin of toxin-antitoxin stability system:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Rhs family protein:Signal transduction histidine kinase:Cell cycle control, cell division, chromosome partitioning:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Base excision repair:General function prediction only:Signal transduction mechanisms:exoDNase_III:phd_fam:YD_repeat_2x:Poorly characterized:Replication and Repair:DNA metabolism:DNA replication, recombination, and repair:Mobile and extrachromosomal element functions:Other:Information storage and processing:Cellular processes and signaling:Genetic Information Processing" 275 "Energy production and conversion:Glycosidases:Superoxide dismutase:Signal transduction histidine kinase:Methyl-accepting chemotaxis protein:ABC-type antimicrobial peptide transport system, ATPase component:Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I):Flagellar biosynthesis pathway, component FlhB:ABC-type Na+ efflux pump, permease component:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Sugar phosphate permease:Hemolysin activation/secretion protein:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:Peptide chain release factor RF-3:Signal transduction histidine kinase:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell motility:Inorganic ion transport and metabolism:Oxidative phosphorylation:Metabolic pathways:Flagellar assembly:Function unknown:Signal transduction mechanisms:sensory_box:small_GTP:flhB:GSu_C4xC__C2xCH:NuoI:VI_chp_4:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Metabolism:Energy Metabolism:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Electron transport:Regulatory functions:Small molecule interactions:Cellular processes:Pathogenesis:Chemotaxis and motility:Unknown function:General:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 276 "Energy production and conversion:Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]:Histidyl-tRNA synthetase:Dihydroxyacid dehydratase/phosphogluconate dehydratase:Diaminopimelate epimerase:Protoheme ferro-lyase (ferrochelatase):Queuine/archaeosine tRNA-ribosyltransferase:Acetolactate synthase, small (regulatory) subunit:Universal stress protein UspA and related nucleotide-binding proteins:Phosphoenolpyruvate carboxykinase (GTP):Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type):ABC-type transport system involved in resistance to organic solvents, auxiliary component:Membrane protein involved in colicin uptake:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Valine leucine and isoleucine biosynthesis:Lysine biosynthesis:Pyruvate metabolism:Butanoate metabolism:C5-Branched dibasic acid metabolism:Pantothenate and CoA biosynthesis:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Phosphotransferase system (PTS):Secondary metabolites biosynthesis, transport and catabolism:Signal transduction mechanisms:hemH:ilvD:acolac_lg:acolac_sm:Q_tRNA_tgt:hisS:DapF:Heme, porphyrin, and cobalamin:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein synthesis:tRNA aminoacylation:tRNA and rRNA base modification:Amino acid biosynthesis:Aspartate family:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism" 277 "Glycosyltransferase:Glycosyltransferases involved in cell wall biogenesis:CDP-diglyceride synthetase:3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases:ADP-heptose:LPS heptosyltransferase:Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase:Inactive homolog of metal-dependent proteases, putative molecular chaperone:3-deoxy-D-manno-octulosonic-acid transferase:Tetraacyldisaccharide-1-P 4'-kinase:Outer membrane protein:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:ABC-type transport system, involved in lipoprotein release, permease component:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Fatty acid biosynthesis:Lipopolysaccharide biosynthesis:Glycerophospholipid metabolism:Metabolic pathways:ABC transporters:Function unknown:tsf:lpxK:fabZ:lipid_A_lpxA:heptsyl_trn_II:lolCE:HpnK:bact_YeaZ:Poorly characterized:Lipid Metabolism:Glycan Biosynthesis and Metabolism:Environmental Information Processing:Membrane Transport:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Protein synthesis:Translation factors:Protein fate:Protein and peptide secretion and trafficking:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cellular processes and signaling:Metabolism:Metabolism" 278 "Energy production and conversion:Aspartyl/asparaginyl-tRNA synthetases:FKBP-type peptidyl-prolyl cis-trans isomerases 1:Signal transduction histidine kinase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:ABC-type transport system involved in cytochrome c biogenesis, permease component:Cation/multidrug efflux pump:Fe-S oxidoreductase:ABC-type cobalt transport system, ATPase component:Flagellar biosynthesis/type III secretory pathway ATPase:Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain:Methylase of chemotaxis methyl-accepting proteins:Uncharacterized membrane protein, possible Na+ channel or pump:Protein involved in cell division:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Hemerythrin:Uncharacterized protein conserved in bacteria:Uncharacterized protein conserved in bacteria:ABC-type transport system, involved in lipoprotein release, permease component:Cell cycle control, cell division, chromosome partitioning:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Aminoacyl-tRNA biosynthesis:ABC transporters:Two-component system:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Signal transduction mechanisms:asnS:fliI_yscN:cbiO:hemeryth_dom:mob_myst_B:pepcterm_CAAX:VI_chp_1:VI_chp_3:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Poorly characterized:Translation:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Energy metabolism:ATP-proton motive force interconversion:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Pathogenesis:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Genetic Information Processing" 279 "Energy production and conversion:Glycogen synthase:Fe-S-cluster-containing hydrogenase components 1:Signal transduction histidine kinase:cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases:Putative intracellular protease/amidase:Predicted nucleoside-diphosphate-sugar epimerases:FOG: CheY-like receiver:Galactose-1-phosphate uridylyltransferase:Alpha-amylase/alpha-mannosidase:Chemotaxis protein; stimulates methylation of MCP proteins:Uncharacterized conserved protein:Uncharacterized protein involved in an early stage of isoprenoid biosynthesis:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Galactose metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Bacterial chemotaxis:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:galT_1:PfpI:glgA:Poorly characterized:Carbohydrate Metabolism:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Biosynthesis and degradation of polysaccharides:Sugars:Protein fate:Degradation of proteins, peptides, and glycopeptides:Cellular processes and signaling:Metabolism:Metabolism" 280 "Adenosylmethionine-8-amino-7-oxononanoate aminotransferase:Dienelactone hydrolase and related enzymes:GMP synthase - Glutamine amidotransferase domain:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):Predicted SAM-dependent methyltransferases:Predicted Fe-S oxidoreductase:Predicted inhibitor of MCP methylation, homolog of CheC:Predicted transcriptional regulators:Flagellar basal body rod protein:Uncharacterized conserved protein:FOG: GGDEF domain:ABC-type molybdate transport system, ATPase component:Uncharacterized conserved protein:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Cell motility:Inorganic ion transport and metabolism:Biotin metabolism:Metabolic pathways:ABC transporters:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00299:bioA:TIGR01212:FlgC:modC_ABC:Information storage and processing:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Transport and binding proteins:Anions:Cellular processes:Chemotaxis and motility:Hypothetical proteins:Conserved:Unknown function:Enzymes of unknown specificity:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 281 "Energy production and conversion:Chloride channel protein EriC:Dihydroorotase and related cyclic amidohydrolases:Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase:Superfamily I DNA and RNA helicases:Dihydrofolate reductase:NAD-dependent DNA ligase (contains BRCT domain type II):DNA mismatch repair enzyme (predicted ATPase):Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:K+ transport systems, NAD-binding component:Nitroreductase:Methyl-accepting chemotaxis protein:Uncharacterized conserved protein:Cobalamin biosynthesis protein CbiD:Coenzyme F420-reducing hydrogenase, gamma subunit:Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase:Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Permeases:K+ transporter:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Cell motility:Inorganic ion transport and metabolism:Pyrimidine metabolism:One carbon pool by folate:Folate biosynthesis:Porphyrin and chlorophyll metabolism:Metabolic pathways:Two-component system:Bacterial chemotaxis:DNA replication:Base excision repair:Nucleotide excision repair:Mismatch repair:General function prediction only:Function unknown:Signal transduction mechanisms:YaeB_AF0241:cbiD:dnlj:mutl:pyrC_multi:L_thr_O3P_dcar:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Heme, porphyrin, and cobalamin:Biosynthesis of cofactors, prosthetic groups, and carriers:Enzymes of unknown specificity:Unknown function:DNA replication, recombination, and repair:DNA metabolism:Pyrimidine ribonucleotide biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism" 282 "Glutamyl- and glutaminyl-tRNA synthetases:Nicotinate-nucleotide pyrophosphorylase:Replicative DNA helicase:DNA repair exonuclease:Kef-type K+ transport systems, membrane components:Predicted transcriptional regulator containing the HTH domain:FOG: LysM repeat:Pyrimidine reductase, riboflavin biosynthesis:Ribosomal protein L11 methylase:Uncharacterized protein conserved in bacteria:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Riboflavin metabolism:Nicotinate and nicotinamide metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Function unknown:nadC:ribD_Cterm:TIGR00281:prmA:gltX_bact:DnaB:Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Chromosome-associated proteins:Protein synthesis:tRNA aminoacylation:Ribosomal proteins: synthesis and modification:Biosynthesis of cofactors, prosthetic groups, and carriers:Pyridine nucleotides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 283 "Energy production and conversion:Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):ATPase components of ABC transporters with duplicated ATPase domains:Ni,Fe-hydrogenase maturation factor:Membrane-fusion protein:NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Fe-S oxidoreductase:ResB protein required for cytochrome c biosynthesis:Predicted Rossmann fold nucleotide-binding protein:Flagellar biosynthesis/type III secretory pathway lipoprotein:Uncharacterized conserved protein:DNA repair proteins:Uncharacterized protein, possibly involved in aromatic compounds catabolism:AraC-type DNA-binding domain-containing proteins:Sugar phosphate permease:Conserved secreted protein:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Metabolic pathways:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:hydrog_prot:hypA:fliF:radc:TIGR00730:RND_mfp:NDH_I_L:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Energy Metabolism:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Electron transport:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein modification and repair:Transport and binding proteins:Unknown substrate:Cellular processes:Chemotaxis and motility:Hypothetical proteins:Conserved:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 284 "Uncharacterized conserved protein:Predicted transcriptional regulator:Uncharacterized protein conserved in bacteria:Transcription:Function unknown:YbgI_SA1388:List_Bact_rpt:Poorly characterized:Information storage and processing:General:Unknown function" 285 "Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains:Transcriptional regulator:ABC-type cobalt transport system, permease component CbiQ and related transporters:Signal transduction histidine kinase:ABC-type cobalt transport system, ATPase component:Precorrin isomerase:Precorrin-6B methylase 1:Signal transduction histidine kinase regulating citrate/malate metabolism:Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:ABC transporters:Two-component system:Signal transduction mechanisms:sensory_box:glmS:cbiO:CbiQ_TIGR:CbiE:Information storage and processing:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Membrane Transport:Signal Transduction:Global:Metabolism:Central intermediary metabolism:Amino sugars:Regulatory functions:Small molecule interactions:Transport and binding proteins:Cations and iron carrying compounds:Metabolism:Cellular processes and signaling:Metabolism" 286 "Histidinol phosphatase and related phosphatases:ATPases involved in chromosome partitioning:Flagellar motor component:Micrococcal nuclease (thermonuclease) homologs:Uncharacterized protein conserved in bacteria:Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Replication, recombination and repair:Cell motility:Lipopolysaccharide biosynthesis:Metabolic pathways:Two-component system:Bacterial chemotaxis:Flagellar assembly:Function unknown:GmhB_yaeD:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Glycan Biosynthesis and Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 287 "Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase:Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains:Kef-type K+ transport systems, membrane components:Zn-dependent protease with chaperone function:Methyl-accepting chemotaxis protein:DNA polymerase III, epsilon subunit and related 3'-5' exonucleases:ABC-type Mn2+/Zn2+ transport systems, permease components:Mismatch repair ATPase (MutS family):Na+/phosphate symporter:DNA replication protein:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Precorrin-6B methylase 2:Transposase and inactivated derivatives:Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Uncharacterized conserved protein:Signal transduction histidine kinase:Coenzyme transport and metabolism:Lipid transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Amino sugar and nucleotide sugar metabolism:Glycerophospholipid metabolism:Thiamine metabolism:Metabolic pathways:ABC transporters:Two-component system:Bacterial chemotaxis:DNA replication:Mismatch repair:Homologous recombination:Function unknown:Signal transduction mechanisms:HMP-P_kinase:sensory_box:HDIG:dnaq:2a37:mutS2:glmS:Cellular processes and signaling:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Membrane Transport:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Central intermediary metabolism:Amino sugars:Regulatory functions:Small molecule interactions:DNA metabolism:Other:Degradation of DNA:Transport and binding proteins:Cations and iron carrying compounds:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 288 "Energy production and conversion:Acetylglutamate semialdehyde dehydrogenase:Glutamate synthase domain 2:Ferredoxin:Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs:Serine phosphatase RsbU, regulator of sigma subunit:Opacity protein and related surface antigens:Amino acid transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Alanine aspartate and glutamate metabolism:Lysine biosynthesis:Arginine and proline metabolism:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Signal transduction mechanisms:sensory_box:TAT_signal_seq:argC:selen_ocin:Protein fate:Energy Metabolism:Amino Acid Metabolism:Global:Metabolism:Regulatory functions:Small molecule interactions:Metabolism:Protein and peptide secretion and trafficking:Amino acid biosynthesis:Glutamate family:Information storage and processing:Cellular processes and signaling:Metabolism" 289 "Energy production and conversion:Argininosuccinate lyase:NTP pyrophosphohydrolases including oxidative damage repair enzymes:Pseudouridylate synthases, 23S RNA-specific:Predicted PP-loop superfamily ATPase:Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit:Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit:Diacylglycerol kinase:Cobalamin biosynthesis protein CobD/CbiB:Transcriptional regulator:Uncharacterized conserved protein:Protein-disulfide isomerase:Uncharacterized protein conserved in bacteria:Rubredoxin:Multisubunit Na+/H+ antiporter, MnhF subunit:Glycine cleavage system regulatory protein:Coenzyme F420-reducing hydrogenase, alpha subunit:Predicted lipoprotein involved in nitrous oxide reduction:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Methane metabolism:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Function unknown:gatC:TIGR00364:cobD:argH:tol_pal_ybgF:Information storage and processing:Energy Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Translation:Global:Metabolism:Protein synthesis:tRNA aminoacylation:Unknown function:General:Amino acid biosynthesis:Glutamate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 290 "Energy production and conversion:Cysteine synthase:Glutamate decarboxylase and related PLP-dependent proteins:Aminopeptidase N:Cytosine deaminase and related metal-dependent hydrolases:Ketopantoate hydroxymethyltransferase:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:2-methylthioadenine synthetase:tmRNA-binding protein:NifU homolog involved in Fe-S cluster formation:Membrane-fusion protein:Serine acetyltransferase:Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes:ATP-utilizing enzymes of the PP-loop superfamily:Predicted transcriptional regulator:O-acetylhomoserine sulfhydrylase:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:beta-Alanine metabolism:Taurine and hypotaurine metabolism:Selenocompound metabolism:Glutathione metabolism:Butanoate metabolism:Thiamine metabolism:Pantothenate and CoA biosynthesis:Sulfur metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Sulfur relay system:General function prediction only:Signal transduction mechanisms:smpB:TIGR00089:panB:sensory_box:TIGR00268:trmU:rrf2_super:cysKM:cysE:OAH_OAS_sulfhy:RND_mfp:NifU_proper:pepN_proteo:FeS_nifS:NOD_PanD_pyr:Pantothenate and coenzyme A:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Metabolism:Metabolism:Global:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism:Central intermediary metabolism:Nitrogen fixation:Regulatory functions:Small molecule interactions:Protein synthesis:Other:tRNA and rRNA base modification:Protein fate:Degradation of proteins, peptides, and glycopeptides:Transport and binding proteins:Unknown substrate:Hypothetical proteins:Conserved:Unknown function:General:Amino acid biosynthesis:Serine family:Biosynthesis of cofactors, prosthetic groups, and carriers" 291 "Energy production and conversion:Exopolyphosphatase:Chemotaxis signal transduction protein:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:Transglutaminase-like enzymes, putative cysteine proteases:ResB protein required for cytochrome c biosynthesis:Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes:Coenzyme F420-reducing hydrogenase, delta subunit:Cobalamin biosynthesis protein CbiG:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Type II secretory pathway, component ExeA (predicted ATPase):Amino acid transport and metabolism:Nucleotide transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Purine metabolism:Glycerophospholipid metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Two-component system:Bacterial chemotaxis:General function prediction only:Signal transduction mechanisms:TIGR00423:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Metabolism:Cellular processes and signaling:Conserved:Hypothetical proteins:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Metabolism of Cofactors and Vitamins:Nucleotide Metabolism:Lipid Metabolism" 292 "Molecular chaperone (small heat shock protein):Geranylgeranyl pyrophosphate synthase:Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain:Molecular chaperone, HSP90 family:DnaJ-class molecular chaperone with C-terminal Zn finger domain:ATPases with chaperone activity, ATP-binding subunit:Uncharacterized membrane protein (homolog of Drosophila rhomboid):Beta-propeller domains of methanol dehydrogenase type:Uncharacterized conserved protein:Dioxygenases related to 2-nitropropane dioxygenase:Predicted membrane protein:Coenzyme transport and metabolism:Posttranslational modification, protein turnover, chaperones:Terpenoid backbone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:General function prediction only:Function unknown:paired_CXXCH_1:degP_htrA_DO:chaperone_ClpB:Poorly characterized:Metabolism of Terpenoids and Polyketides:Global:Metabolism:Protein fate:Protein folding and stabilization:Degradation of proteins, peptides, and glycopeptides:Cellular processes and signaling:Metabolism:Metabolism" 293 "Energy production and conversion:Cation transport ATPase:NTP pyrophosphohydrolases including oxidative damage repair enzymes:Ni,Fe-hydrogenase maturation factor:Glutaredoxin and related proteins:ABC-type antimicrobial peptide transport system, ATPase component:Na+/phosphate symporter:FOG: HEAT repeat:Multidrug resistance efflux pump:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB:Predicted phosphoglycerate mutase, AP superfamily:Response regulator containing a CheY-like receiver domain and a GGDEF domain:Type I site-specific restriction-modification system, R (restriction) subunit and related helicases:Site-specific recombinase XerD:Signal transduction histidine kinase:Carbohydrate transport and metabolism:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Fatty acid biosynthesis:Purine metabolism:Methane metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:hydrog_prot:sensory_box:GGDEF:apgM:ATPase_P-type:type_I_hlyD:GlrX_YruB:recomb_XerD:Defense mechanisms:Signal transduction:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Protein fate:Protein and peptide secretion and trafficking:Metabolism:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 294 "Energy production and conversion:Glycosyltransferases involved in cell wall biogenesis:Transcriptional regulator:Arylsulfatase regulator (Fe-S oxidoreductase):Signal transduction histidine kinase:Small-conductance mechanosensitive channel:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Flagellar biosynthesis pathway, component FlhA:Uncharacterized flagellar protein FlaG:2'-5' RNA ligase:Molybdopterin converting factor, small subunit:Uncharacterized protein conserved in bacteria:Methylase of polypeptide chain release factors:Delta 1-pyrroline-5-carboxylate dehydrogenase:ABC-type taurine transport system, periplasmic component:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Alanine aspartate and glutamate metabolism:Arginine and proline metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Flagellar assembly:Sulfur relay system:General function prediction only:Function unknown:Signal transduction mechanisms:hemK_fam:D1pyr5carbox2:FlhA:moaD_arch:2_5_ligase:rSAM_more_4Fe4S:Intracellular trafficking, secretion, and vesicular transport:Molybdopterin:Amino Acid Metabolism:Genetic Information Processing:Folding Sorting and Degradation:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Amino acids and amines:Transcription:RNA processing:Protein fate:Protein modification and repair:Cellular processes:Chemotaxis and motility:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 295 "Energy production and conversion:Ribonuclease D:Cobalamin-5-phosphate synthase:UDP-N-acetylglucosamine 2-epimerase:Prolyl-tRNA synthetase:Phosphopantothenoylcysteine synthetase/decarboxylase:Aspartate carbamoyltransferase, catalytic chain:Signal transduction histidine kinase:Uncharacterized membrane protein, putative virulence factor:Holliday junction resolvasome, endonuclease subunit:Zn-dependent alcohol dehydrogenases:Methylase of chemotaxis methyl-accepting proteins:Outer membrane protein:Uncharacterized homolog of PSP1:Transcriptional regulator/sugar kinase:Uncharacterized bacitracin resistance protein:Transcriptional regulators:Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Permeases of the major facilitator superfamily:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:ABC-type uncharacterized transport system, periplasmic component:K+ transporter:Signal transduction histidine kinase regulating citrate/malate metabolism:Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Galactose metabolism:Fatty acid metabolism:Pyrimidine metabolism:Alanine aspartate and glutamate metabolism:Tyrosine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Peptidoglycan biosynthesis:Chloroalkane and chloroalkene degradation:Naphthalene degradation:Pantothenate and CoA biosynthesis:Porphyrin and chlorophyll metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:ruvC:sensory_box:wecB:cobS:proS_fam_II:coaBC_dfp:asp_carb_tr:undec_PP_bacA:mviN:adh_fam_2:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Cellular processes and signaling:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Biosynthesis of Other Secondary Metabolites:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Translation:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Fermentation:Purines, pyrimidines, nucleosides, and nucleotides:Pyrimidine ribonucleotide biosynthesis:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Pantothenate and coenzyme A:Cell envelope:Biosynthesis and degradation of murein sacculus and peptidoglycan:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 296 "Energy production and conversion:Lipoate-protein ligase A:Lipoate synthase:Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain:Glycine cleavage system T protein (aminomethyltransferase):Glycine cleavage system H protein (lipoate-binding):Cation/multidrug efflux pump:Membrane-fusion protein:Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain:DNA-directed RNA polymerase specialized sigma subunit:RecG-like helicase:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Transcriptional regulator:Methylase of chemotaxis methyl-accepting proteins:Predicted redox protein, regulator of disulfide bond formation:Trehalose-6-phosphatase:Predicted hydrolase (HD superfamily):Predicted permeases:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Glycine serine and threonine metabolism:Starch and sucrose metabolism:One carbon pool by folate:Lipoic acid metabolism:Nitrogen metabolism:Metabolic pathways:Two-component system:RNA polymerase:Homologous recombination:General function prediction only:Signal transduction mechanisms:HDIG:lipA:gcvH:gcvT:recG:T6PP:RND_mfp:FliA_WhiG:Defense mechanisms:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Lipoate:Biosynthesis of cofactors, prosthetic groups, and carriers:Adaptations to atypical conditions:Cellular processes:Unknown substrate:Transport and binding proteins:DNA replication, recombination, and repair:DNA metabolism:Amino acids and amines:Energy metabolism:Metabolism:Global:Signal Transduction:Environmental Information Processing:Replication and Repair:Transcription:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism" 297 "Energy production and conversion:Malate/lactate dehydrogenases:Ribosomal protein S20:NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases:NADH:ubiquinone oxidoreductase 49 kD subunit 7:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K):NADH:ubiquinone oxidoreductase subunit 6 (chain J):NADH:ubiquinone oxidoreductase 27 kD subunit:NADH:ubiquinone oxidoreductase subunit 2 (chain N):NADH:ubiquinone oxidoreductase subunit 4 (chain M):NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I):Transcriptional regulators:Monomeric isocitrate dehydrogenase:Translation, ribosomal structure and biogenesis:Transcription:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Oxidative phosphorylation:Glutathione metabolism:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:S20:monomer_idh:MalateDH_bact:NDH_I_N:nuoB_fam:NuoC_fam:NuoD:NuoI:NDH_I_M:NDH_I_L:Metabolism:Information storage and processing:Ribosomal proteins: synthesis and modification:Protein synthesis:TCA cycle:Electron transport:Energy metabolism:Metabolism:Metabolism:Global:Translation:Genetic Information Processing:Metabolism of Other Amino Acids:Energy Metabolism:Carbohydrate Metabolism" 298 "DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32):RecG-like helicase:Uncharacterized protein conserved in bacteria:Transcriptional accessory protein:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Transcription:Replication, recombination and repair:Two-component system:RNA polymerase:Homologous recombination:Function unknown:Signal transduction mechanisms:recG:rpoH_proteo:Transcription factors:Transcription:Replication and Repair:Environmental Information Processing:Signal Transduction:DNA metabolism:DNA replication, recombination, and repair:Transcription:Genetic Information Processing:Information storage and processing:Cellular processes and signaling:Poorly characterized" 299 "Energy production and conversion:FOG: CheY-like receiver:Chemotaxis signal transduction protein:NADH:ubiquinone oxidoreductase subunit 3 (chain A):NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G):Uncharacterized protein conserved in bacteria:Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain:Copper chaperone:Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism:Hemolysin activation/secretion protein:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Transcription:Cell motility:Inorganic ion transport and metabolism:Oxidative phosphorylation:Metabolic pathways:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Bacterial secretion system:Function unknown:Signal transduction mechanisms:phnA:NuoG:Intracellular trafficking, secretion, and vesicular transport:Unknown function:Electron transport:Energy metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Metabolism:Membrane Transport:Environmental Information Processing:General:Energy Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 300 "Energy production and conversion:Glutamyl- and glutaminyl-tRNA synthetases:Polyprenyltransferase (cytochrome oxidase assembly factor):6-phosphofructokinase:Thiol-disulfide isomerase and thioredoxins:Exonuclease III:Uncharacterized membrane protein, putative virulence factor:Chemotaxis signal transduction protein:DNA polymerase III, epsilon subunit and related 3'-5' exonucleases:Uncharacterized conserved protein:DNA replication protein:DNA-binding protein, stimulates sugar fermentation:Uroporphyrinogen-III synthase:Trehalose-6-phosphatase:Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase:Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB:Permeases of the major facilitator superfamily:Transposase and inactivated derivatives:Rhs family protein:ABC-type uncharacterized transport system, permease component:Transposase and inactivated derivatives:Uncharacterized protein conserved in bacteria:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Pentose phosphate pathway:Fructose and mannose metabolism:Galactose metabolism:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Starch and sucrose metabolism:Peptidoglycan biosynthesis:Methane metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:DNA replication:Base excision repair:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:Signal transduction mechanisms:exoDNase_III:sfsA:dnaq:T6PP:cobA_cysG_Cterm:YD_repeat_2x:mviN:PFK_mixed:shape_MreD:Rhs_assc_core:queuosine_YadB:Biosynthesis and degradation of murein sacculus and peptidoglycan:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Glycan Biosynthesis and Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Replication and Repair:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Glycolysis/gluconeogenesis:Regulatory functions:Other:DNA metabolism:Degradation of DNA:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Cellular processes:Adaptations to atypical conditions:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Cell envelope:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 301 "Energy production and conversion:Predicted sugar kinase:FAD synthase:Dihydrofolate reductase:Predicted methyltransferases:ATPase involved in DNA repair:Valyl-tRNA synthetase:Single-stranded DNA-specific exonuclease:dTDP-4-dehydrorhamnose reductase:Ferredoxin:Predicted rRNA methylase:Recombinational DNA repair ATPase (RecF pathway):Predicted glycosyltransferases:Predicted inhibitor of MCP methylation, homolog of CheC:Membrane protein involved in the export of O-antigen and teichoic acid:Uncharacterized conserved protein:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Valine leucine and isoleucine biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Riboflavin metabolism:Nicotinate and nicotinamide metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Base excision repair:Mismatch repair:Homologous recombination:General function prediction only:Function unknown:ribF:TIGR00096:valS:tly:recf:recN:recJ:Poorly characterized:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Replication and Repair:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Unknown function:Enzymes of unknown specificity:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Riboflavin, FMN, and FAD:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 302 "ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component:Amino acid transport and metabolism:Inorganic ion transport and metabolism:ABC transporters:oligo_HPY:Amino acids, peptides and amines:Membrane Transport:Transport and binding proteins:Environmental Information Processing:Metabolism" 303 "Carbonic anhydrase:Uncharacterized membrane-associated protein:Parvulin-like peptidyl-prolyl isomerase:ABC-type multidrug transport system, ATPase component:DNA-binding HTH domain-containing proteins:Hemolysin-coregulated protein (uncharacterized):Uncharacterized protein conserved in bacteria:Site-specific recombinase XerD:Transcription:Replication, recombination and repair:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Nitrogen metabolism:Bacterial secretion system:Function unknown:fkbM_fam:casC_Cse4:casE_Cse3:integrase_gron:VI_effect_Hcp1:VI_chp_5:Defense mechanisms:Cellular processes and signaling:Energy Metabolism:Environmental Information Processing:Membrane Transport:Cellular processes:Pathogenesis:Mobile and extrachromosomal element functions:Other:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 304 "Energy production and conversion:Diaminopimelate decarboxylase:Pyrroline-5-carboxylate reductase:Zn finger protein HypA/HybF (possibly regulating hydrogenase expression):Glycine cleavage system T protein (aminomethyltransferase):ATPases of the AAA+ class:Nitroreductase:FOG: CheY-like receiver:Methyl-accepting chemotaxis protein:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Predicted transcriptional regulators:Predicted signal transduction protein:Saccharopine dehydrogenase and related proteins:Uncharacterized protein, 4-oxalocrotonate tautomerase homolog:3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Nitrate/nitrite transporter:ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain:Amino acid transport and metabolism:Lipid transport and metabolism:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycine serine and threonine metabolism:Valine leucine and isoleucine degradation:Lysine biosynthesis:Lysine degradation:Arginine and proline metabolism:Benzoate degradation:One carbon pool by folate:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:General function prediction only:Signal transduction mechanisms:taut:hypA:proC:HDIG:gcvT:nspC:cytochr_NrfH:Defense mechanisms:Glutamate family:Amino acid biosynthesis:Protein modification and repair:Protein fate:Other:Electron transport:Amino acids and amines:Energy metabolism:Polyamine biosynthesis:Central intermediary metabolism:Metabolism:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Xenobiotics Biodegradation and Metabolism:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Metabolism:Energy Metabolism:Poorly characterized:Cellular processes and signaling:Information storage and processing" 305 "Energy production and conversion:NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases:NADH:ubiquinone oxidoreductase 49 kD subunit 7:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit:NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K):NADH:ubiquinone oxidoreductase subunit 6 (chain J):NADH:ubiquinone oxidoreductase 27 kD subunit:NADH:ubiquinone oxidoreductase subunit 1 (chain H):NADH:ubiquinone oxidoreductase subunit 2 (chain N):NADH:ubiquinone oxidoreductase subunit 4 (chain M):NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit:Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit:Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I):NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit:Uncharacterized anaerobic dehydrogenase:Inorganic ion transport and metabolism:Citrate cycle (TCA cycle):Oxidative phosphorylation:Carbon fixation pathways in prokaryotes:Metabolic pathways:Microbial metabolism in diverse environments:General function prediction only:NDH_I_N:nuoB_fam:NuoC_fam:NuoD:NuoI:NDH_I_M:NDH_I_L:Metabolism:Carbohydrate Metabolism:Energy Metabolism:Global:Metabolism:Energy metabolism:Electron transport:Metabolism:Poorly characterized" 306 "Energy production and conversion:Predicted sugar kinase:Anaerobic dehydrogenases, typically selenocysteine-containing:Replicative DNA helicase:Guanosine polyphosphate pyrophosphohydrolases/synthetases:Nucleoside-diphosphate-sugar epimerases:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Predicted sugar phosphate isomerase involved in capsule formation:ADP-ribose pyrophosphatase:dTDP-4-dehydrorhamnose reductase:UDP-glucose pyrophosphorylase:CMP-2-keto-3-deoxyoctulosonic acid synthetase:Predicted glycosyltransferases:Uncharacterized membrane protein:DNA uptake protein and related DNA-binding proteins:Predicted ATPase (AAA+ superfamily):Response regulator containing a CheY-like receiver domain and an HD-GYP domain:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Pentose and glucuronate interconversions:Galactose metabolism:Purine metabolism:Starch and sucrose metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Lipopolysaccharide biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:DNA replication:General function prediction only:Function unknown:Signal transduction mechanisms:yjeF_cterm:kpsF:kdsB:DnaB:spoT_relA:galU:rmlD:Information storage and processing:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:General:Unknown function:Adaptations to atypical conditions:Cellular processes:DNA replication, recombination, and repair:DNA metabolism:Sugars:Energy metabolism:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Replication and Repair:Genetic Information Processing:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Glycan Biosynthesis and Metabolism:Nucleotide Metabolism:Metabolism:Carbohydrate Metabolism:Poorly characterized:Cellular processes and signaling" 307 "Energy production and conversion:Nitroreductase:FOG: CheY-like receiver:Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain:Anaerobic C4-dicarboxylate transporter:Uncharacterized conserved protein:Transcription:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:Dcu:PEP_exosort:Metabolism:Signal Transduction:Transport and binding proteins:Carbohydrates, organic alcohols, and acids:Cell envelope:Surface structures:Information storage and processing:Cellular processes and signaling:Environmental Information Processing:Poorly characterized" 308 "Energy production and conversion:Queuine/archaeosine tRNA-ribosyltransferase:UDP-N-acetylglucosamine 2-epimerase:Acetyl-CoA hydrolase:Selenocysteine lyase:Sugar phosphate isomerases/epimerases:Transcriptional regulator:Multiple antibiotic transporter:Tfp pilus assembly protein, pilus retraction ATPase PilT:K+ transporter:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:wecB:TIGR00427:Q_tRNA_tgt:pilT_fam:am_tr_V_EF2568:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Information storage and processing:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Cell envelope:General:Enzymes of unknown specificity:Unknown function:Chemotaxis and motility:Cellular processes:tRNA and rRNA base modification:Protein synthesis:Metabolism:Metabolism:Global:Metabolism:Carbohydrate Metabolism" 309 "Xaa-Pro aminopeptidase:Phosphoglycerate dehydrogenase and related dehydrogenases:Methionyl-tRNA synthetase:Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases:Preprotein translocase subunit SecF:Biotin carboxylase:Nucleoside-diphosphate-sugar epimerases:Glycine cleavage system H protein (lipoate-binding):Biotin carboxyl carrier protein:IMP dehydrogenase/GMP reductase:Predicted Fe-S oxidoreductases:Organic radical activating enzymes:ABC-type transport system involved in cytochrome c biogenesis, permease component:Parvulin-like peptidyl-prolyl isomerase:FOG: CheY-like receiver:ABC-type uncharacterized transport system, ATPase component:Deoxyxylulose-5-phosphate synthase:ResB protein required for cytochrome c biosynthesis:Uncharacterized protein, putative amidase:Uncharacterized conserved protein:Squalene cyclase:Uncharacterized protein conserved in bacteria:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Fatty acid biosynthesis:Purine metabolism:Pyrimidine metabolism:Glycine serine and threonine metabolism:Arginine and proline metabolism:Selenocompound metabolism:Pyruvate metabolism:Propanoate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Terpenoid backbone biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA polymerase:General function prediction only:Function unknown:Signal transduction mechanisms:dxs:metG:accC:gcvH:BCCP:IMP_dehydrog:PGDH:hopene_cyclase:paired_CXXCH_1:rpoB:cytochr_II_ccsB:HpnA:HpnH:HpnN:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Metabolism of Other Amino Acids:Metabolism of Terpenoids and Polyketides:Genetic Information Processing:Transcription:Translation:Global:Metabolism:Energy metabolism:Amino acids and amines:Fatty acid and phospholipid metabolism:Other:Biosynthesis:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Transcription:DNA-dependent RNA polymerase:Protein synthesis:tRNA aminoacylation:Protein fate:Protein modification and repair:Amino acid biosynthesis:Serine family:Biosynthesis of cofactors, prosthetic groups, and carriers:Thiamine:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 310 "Energy production and conversion:Superoxide dismutase:Putative intracellular protease/amidase:Rieske Fe-S protein:Membrane-fusion protein:ABC-type antimicrobial peptide transport system, ATPase component:Cytochrome b subunit of the bc complex:Heme/copper-type cytochrome/quinol oxidase, subunit 3:Uncharacterized protein with SCP/PR1 domains:Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation):Predicted membrane protein:Uncharacterized protein conserved in bacteria:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Oxidative phosphorylation:Metabolic pathways:General function prediction only:Function unknown:PfpI:TAT_signal_seq:RND_mfp:Defense mechanisms:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Unknown substrate:Transport and binding proteins:Degradation of proteins, peptides, and glycopeptides:Protein and peptide secretion and trafficking:Protein fate:Metabolism:Global:Energy Metabolism" 311 "Energy production and conversion:Predicted Fe-S oxidoreductases:Permeases of the drug/metabolite transporter (DMT) superfamily:Fe-S oxidoreductase:Flagellar motor protein:Uncharacterized conserved protein:Desulfoferrodoxin:Predicted GTPase:Uncharacterized metal-binding protein conserved in archaea:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Cell motility:Bacterial chemotaxis:Flagellar assembly:General function prediction only:Function unknown:Cell Motility:Poorly characterized:Metabolism:Cellular processes and signaling:Cellular Processes" 312 "Energy production and conversion:ATPases involved in chromosome partitioning:ABC-type phosphate transport system, permease component:FOG: CheY-like receiver:ABC-type antimicrobial peptide transport system, ATPase component:DNA-directed RNA polymerase specialized sigma subunit:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes:Flagellar biosynthesis pathway, component FlhA:Flagellar GTP-binding protein:Flagellar basal body rod protein:ABC-type transport system, involved in lipoprotein release, permease component:Flagellar basal body rod protein:Cell cycle control, cell division, chromosome partitioning:Transcription:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:ABC transporters:Two-component system:Flagellar assembly:RNA polymerase:Signal transduction mechanisms:FlgC:FlhA:paired_CXXCH_1:MerA:phosphate_pstC:FliA_WhiG:flgF:FlhF:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Membrane Transport:Environmental Information Processing:Anions:Transcription:Cellular processes:Detoxification:Chemotaxis and motility:Information storage and processing:Cellular processes and signaling:Metabolism:Transport and binding proteins:Genetic Information Processing:Cell Motility:Cellular Processes:Signal Transduction" 313 "Adenylosuccinate lyase:Glutamine phosphoribosylpyrophosphate amidotransferase:Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain:Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain:Phenylalanyl-tRNA synthetase beta subunit:Glycosyltransferase:Small-conductance mechanosensitive channel:Signal peptidase I:Protoporphyrinogen oxidase:Type II secretory pathway, component PulF:Serine kinase of the HPr protein, regulates carbohydrate metabolism:Cell division protein:Predicted ATPase involved in cell division:Transketolase, N-terminal subunit:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Pentose phosphate pathway:Purine metabolism:Alanine aspartate and glutamate metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Protein export:Signal transduction mechanisms:pheT_bact:hpr-ser:purB:purF:sigpep_I_bact:FtsE:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Carbohydrate Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Purine ribonucleotide biosynthesis:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Cell division:Signal transduction:PTS:Information storage and processing:Cellular processes and signaling:Metabolism" 314 "Energy production and conversion:Predicted enzyme with a TIM-barrel fold:Translation initiation factor 1 (IF-1):Lactate dehydrogenase and related dehydrogenases:Predicted membrane protein:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Glycine serine and threonine metabolism:Glyoxylate and dicarboxylate metabolism:Methane metabolism:Metabolic pathways:Microbial metabolism in diverse environments:General function prediction only:Function unknown:infA:TIGR00044:Translation factors:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Global:Metabolism:Protein synthesis:Metabolism:Unknown function:Enzymes of unknown specificity:Information storage and processing:Metabolism:Poorly characterized" 315 "Energy production and conversion:Isopropylmalate/homocitrate/citramalate synthases:Imidazoleglycerol-phosphate dehydratase:Ribosomal protein S14:Peroxiredoxin:Glycosyltransferases involved in cell wall biogenesis:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:Biotin synthase and related enzymes:Preprotein translocase subunit YidC:Predicted glycosyltransferases:Metal-dependent hydrolases of the beta-lactamase superfamily I:Predicted membrane protein:Cytochrome bd-type quinol oxidase, subunit 1:Cytochrome bd-type quinol oxidase, subunit 2:Uncharacterized conserved protein:Uncharacterized host factor I protein:Predicted transcriptional regulator:Peroxiredoxin:Predicted transcriptional regulator:Amino acid transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Oxidative phosphorylation:Valine leucine and isoleucine biosynthesis:Histidine metabolism:Pyruvate metabolism:Biotin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:RNA degradation:Protein export:Bacterial secretion system:General function prediction only:Function unknown:cydB:bioB:rrf2_super:leuA_bact:Hfq:casB_cse2:yidC_oxa1_cterm:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Poorly characterized:Protein and peptide secretion and trafficking:Protein fate:Other:Regulatory functions:Electron transport:Energy metabolism:Metabolism:Global:Metabolism:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Translation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Mobile and extrachromosomal element functions:Carbohydrate Metabolism:Other:Unknown function:General:Amino acid biosynthesis:Pyruvate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Biotin:Information storage and processing:Cellular processes and signaling" 316 "Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain:Predicted Co/Zn/Cd cation transporters:Tyrosyl-tRNA synthetase:UDP-N-acetylglucosamine 2-epimerase:Fatty acid/phospholipid biosynthesis enzyme:Glycosyltransferase:Aspartokinases:ATPase involved in DNA replication initiation:Small-conductance mechanosensitive channel:Signal peptidase I:Cell division protein:Predicted ATPase involved in cell division:Cell division protein:Type II secretory pathway, component HofQ:Predicted methyltransferase (contains TPR repeat):Cell cycle control, cell division, chromosome partitioning:Amino acid transport and metabolism:Nucleotide transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Purine metabolism:Glycine serine and threonine metabolism:Cysteine and methionine metabolism:Lysine biosynthesis:Amino sugar and nucleotide sugar metabolism:Glycerolipid metabolism:Glycerophospholipid metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Protein export:Bacterial secretion system:General function prediction only:plsX:tyrS:wecB:DnaA:asp_kin_monofn:CDF:sigpep_I_bact:FtsE:Intracellular trafficking, secretion, and vesicular transport:Cell envelope:Carbohydrate Metabolism:Lipid Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Cell division:Amino acid biosynthesis:Aspartate family:Metabolism:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 317 "Superfamily I DNA and RNA helicases:Fe2+ transport system protein B:4-hydroxybenzoate polyprenyltransferase and related prenyltransferases:Protein-tyrosine-phosphatase:Transcriptional regulator:Predicted transcriptional regulators:Signal transduction histidine kinase:Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family:Transcription elongation factor:Methyl-accepting chemotaxis protein:FOG: PAS/PAC domain:Serine phosphatase RsbU, regulator of sigma subunit:Precorrin-6B methylase 2:K+ transporter:Carbohydrate-selective porin:Coenzyme transport and metabolism:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Ubiquinone and other terpenoid-quinone biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Signal transduction mechanisms:sensory_box:small_GTP:ubiA_other:cas_GSU0053:Mobile and extrachromosomal element functions:Small molecule interactions:Regulatory functions:Metabolism:Global:Metabolism:Metabolism of Cofactors and Vitamins:Cellular processes and signaling:Information storage and processing:Menaquinone and ubiquinone:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:General:Unknown function:Other" 318 "Energy production and conversion:Superfamily I DNA and RNA helicases:Folylpolyglutamate synthase:Fe2+ transport system protein B:Cation transport ATPase:Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain:NTP pyrophosphohydrolases including oxidative damage repair enzymes:Predicted xylanase/chitin deacetylase:NifU homolog involved in Fe-S cluster formation:Fe-S oxidoreductase:Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes:ABC-type antimicrobial peptide transport system, ATPase component:Mn-dependent transcriptional regulator:Predicted membrane-associated HD superfamily hydrolase:ATP-utilizing enzymes of the PP-loop superfamily:DNA polymerase III, gamma/tau subunits:Molybdenum cofactor biosynthesis enzyme:Predicted permeases:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Inorganic ion transport and metabolism:Purine metabolism:Pyrimidine metabolism:Folate biosynthesis:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:ABC transporters:DNA replication:Mismatch repair:Homologous recombination:Sulfur relay system:General function prediction only:small_GTP:TIGR00268:HDIG:TIGR00423:rarD:ATPase_P-type:folC:NifU_proper:dnaX_nterm:moaA:Defense mechanisms:Metabolism:Nucleotide Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:Central intermediary metabolism:Nitrogen fixation:DNA metabolism:DNA replication, recombination, and repair:Transport and binding proteins:Unknown substrate:Hypothetical proteins:Conserved:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Folic acid:Molybdopterin:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 319 "Molybdopterin converting factor, large subunit:UDP-N-acetyl-D-mannosaminuronate dehydrogenase:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Sec-independent protein secretion pathway component TatC:Periplasmic protein involved in polysaccharide export:Cation transport ATPase:Hemerythrin:Predicted permease:ABC-type tungstate transport system, permease component:Uncharacterized conserved protein:Predicted membrane protein:Uncharacterized conserved protein:Coenzyme transport and metabolism:Transcription:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Amino sugar and nucleotide sugar metabolism:ABC transporters:Protein export:Bacterial secretion system:Sulfur relay system:General function prediction only:Function unknown:Signal transduction mechanisms:tatC:ATPase_P-type:YidE_YbjL_dupl:hemeryth_dom:NDP-sugDHase:Intracellular trafficking, secretion, and vesicular transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Information storage and processing:Carbohydrate Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized:Unknown substrate:Transport and binding proteins:Protein and peptide secretion and trafficking:Protein fate:Metabolism:Membrane Transport" 320 "Energy production and conversion:Carbonic anhydrase:Glycogen synthase:Polyferredoxin:Phosphoenolpyruvate synthase/pyruvate phosphate dikinase:Signal transduction histidine kinase:Predicted membrane GTPase involved in stress response:Peroxiredoxin:Electron transfer flavoprotein, beta subunit:Uncharacterized conserved protein:Carbohydrate transport and metabolism:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Starch and sucrose metabolism:Pyruvate metabolism:Methane metabolism:Carbon fixation pathways in prokaryotes:Nitrogen metabolism:Metabolic pathways:Microbial metabolism in diverse environments:Function unknown:Signal transduction mechanisms:small_GTP:PEP_synth:glgA:CxxC_CxxC_SSSS:Biosynthesis and degradation of polysaccharides:Glycolysis/gluconeogenesis:Energy metabolism:Metabolism:Metabolism:Global:Energy Metabolism:Regulatory functions:Carbohydrate Metabolism:DNA interactions:Unknown function:General:Cellular processes and signaling:Metabolism:Poorly characterized" 321 "Energy production and conversion:Gamma-glutamyl phosphate reductase:Cysteine synthase:Geranylgeranyl pyrophosphate synthase:Methionyl-tRNA formyltransferase:Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases:Fe-S oxidoreductase:FAD/FMN-containing dehydrogenases:Catalase (peroxidase I):Zn-dependent protease with chaperone function:tRNA nucleotidyltransferase/poly(A) polymerase:2-methylthioadenine synthetase:Acetyl-CoA carboxylase alpha subunit:Chemotaxis signal transduction protein:Disulfide bond chaperones of the HSP33 family:Amidases related to nicotinamidase:Cellulase M and related proteins:Predicted oxidoreductases of the aldo/keto reductase family:dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes:FOG: GGDEF domain:Cytochrome c2:Uncharacterized conserved protein:ABC-type uncharacterized transport system, permease component:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Cysteine and methionine metabolism:Arginine and proline metabolism:Phenylalanine metabolism:Tryptophan metabolism:Selenocompound metabolism:Starch and sucrose metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Pyruvate metabolism:Glyoxylate and dicarboxylate metabolism:Propanoate metabolism:One carbon pool by folate:Methane metabolism:Carbon fixation pathways in prokaryotes:Nicotinate and nicotinamide metabolism:Terpenoid backbone biosynthesis:Sulfur metabolism:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:Flagellar assembly:RNA degradation:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:TIGR00089:cat_per_HPI:GGDEF:proA:fmt:accA:cysKM:tonB_Cterm:FlgM_jcvi:Amino Acid Metabolism:Lipid Metabolism:Energy Metabolism:Metabolism:Carbohydrate Metabolism:Fatty acid and phospholipid metabolism:Biosynthesis:Protein synthesis:tRNA aminoacylation:Transport and binding proteins:Cations and iron carrying compounds:Cellular processes:Detoxification:Amino acid biosynthesis:Glutamate family:Serine family:Signal transduction:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized:Global:Cell Motility:Cellular Processes:Signal Transduction:Environmental Information Processing:Folding Sorting and Degradation:Translation:Genetic Information Processing:Metabolism:Biosynthesis of Other Secondary Metabolites:Metabolism of Terpenoids and Polyketides:Metabolism of Cofactors and Vitamins:Metabolism of Other Amino Acids" 322 "Energy production and conversion:Nucleotidyltransferase/DNA polymerase involved in DNA repair:Hydrogenase maturation factor:Methionine synthase I (cobalamin-dependent), methyltransferase domain:MoxR-like ATPases:Zn-dependent alcohol dehydrogenases:Fe-S-cluster-containing hydrogenase components 2:Flagellar biosynthesis/type III secretory pathway protein:Flagellar motor protein:Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase:Formate/nitrite family of transporters:Tfp pilus assembly protein, pilus retraction ATPase PilT:Amino acid transport and metabolism:Lipid transport and metabolism:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Fatty acid metabolism:Cysteine and methionine metabolism:Tyrosine metabolism:Chloroalkane and chloroalkene degradation:Naphthalene degradation:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Bacterial chemotaxis:Flagellar assembly:Bacterial secretion system:General function prediction only:hypD:pilT_fam:adh_fam_2:Intracellular trafficking, secretion, and vesicular transport:Metabolism:Carbohydrate Metabolism:Lipid Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Xenobiotics Biodegradation and Metabolism:Environmental Information Processing:Membrane Transport:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:Fermentation:Protein fate:Protein modification and repair:Cellular processes:Chemotaxis and motility:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 323 "Energy production and conversion:Zn-dependent protease with chaperone function:Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain:Fe-S oxidoreductase:Methylase of chemotaxis methyl-accepting proteins:2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase:Coenzyme transport and metabolism:Transcription:Cell motility:Posttranslational modification, protein turnover, chaperones:Two-component system:Bacterial chemotaxis:Signal transduction mechanisms:Environmental Information Processing:Metabolism:Cellular processes and signaling:Information storage and processing:Cell Motility:Cellular Processes:Signal Transduction" 324 "Phosphoribosyl-ATP pyrophosphohydrolase:Putative translation initiation inhibitor, yjgF family:ATP-dependent Lon protease, bacterial type:Signal transduction histidine kinase:NAD-dependent protein deacetylases, SIR2 family:ADP-heptose:LPS heptosyltransferase:FKBP-type peptidyl-prolyl cis-trans isomerases 2:Predicted rRNA methylase:Uncharacterized conserved protein:Site-specific recombinase XerD:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Histidine metabolism:Lipopolysaccharide biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Function unknown:Signal transduction mechanisms:TIGR00004:YbaK_EbsC:tly:lon:heptsyl_trn_III:integrase_gron:histidine_hisI:Poorly characterized:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Global:Metabolism:Transcription:Degradation of RNA:Protein fate:Degradation of proteins, peptides, and glycopeptides:Mobile and extrachromosomal element functions:Other:Unknown function:General:Amino acid biosynthesis:Histidine family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 325 "Energy production and conversion:Molecular chaperone (small heat shock protein):Molecular chaperone, HSP90 family:DnaJ-class molecular chaperone with C-terminal Zn finger domain:ATPases with chaperone activity, ATP-binding subunit:Uncharacterized membrane protein (homolog of Drosophila rhomboid):Fe-S oxidoreductase:Uncharacterized low-complexity proteins:Uncharacterized protein conserved in bacteria:Beta-propeller domains of methanol dehydrogenase type:Posttranslational modification, protein turnover, chaperones:General function prediction only:Function unknown:chaperone_ClpB:Poorly characterized:Metabolism:Cellular processes and signaling:Protein folding and stabilization:Protein fate" 326 "Energy production and conversion:Molecular chaperone (small heat shock protein):Succinyl-CoA synthetase, alpha subunit:Pseudouridylate synthases, 23S RNA-specific:Thiamine monophosphate kinase:Chemotaxis protein histidine kinase and related kinases:FOG: CheY-like receiver:Chemotaxis signal transduction protein:Methyl-accepting chemotaxis protein:Membrane-fusion protein:Methylase of chemotaxis methyl-accepting proteins:Predicted redox protein, regulator of disulfide bond formation:Chemotaxis protein CheC, inhibitor of MCP methylation:Predicted CoA-binding protein:Chemotaxis protein; stimulates methylation of MCP proteins:Outer membrane lipoprotein-sorting protein:Uncharacterized conserved protein:Signal transduction histidine kinase regulating citrate/malate metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Citrate cycle (TCA cycle):Propanoate metabolism:C5-Branched dibasic acid metabolism:Carbon fixation pathways in prokaryotes:Thiamine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Two-component system:Bacterial chemotaxis:General function prediction only:Function unknown:Signal transduction mechanisms:rluA_subfam:sucCoAalpha:thiL:RND_mfp:Thiamine:Carbohydrate Metabolism:Energy Metabolism:Metabolism of Cofactors and Vitamins:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Energy metabolism:TCA cycle:Protein synthesis:tRNA and rRNA base modification:Transport and binding proteins:Unknown substrate:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 327 "Energy production and conversion:Excinuclease ATPase subunit:Ribonuclease HI:NAD-dependent aldehyde dehydrogenases:Serine acetyltransferase:ATPase components of various ABC-type transport systems, contain duplicated ATPase:Protoporphyrinogen oxidase:Type II secretory pathway, prepilin signal peptidase PulO and related peptidases:Membrane protein involved in the export of O-antigen and teichoic acid:ATPase related to the helicase subunit of the Holliday junction resolvase:Uncharacterized protein conserved in bacteria:Signal transduction histidine kinase:Amino acid transport and metabolism:Coenzyme transport and metabolism:Replication, recombination and repair:Cell motility:Posttranslational modification, protein turnover, chaperones:Geraniol degradation:Polycyclic aromatic hydrocarbon degradation:Naphthalene degradation:Limonene and pinene degradation:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:DNA replication:Nucleotide excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:sensory_box:uvra:VI_chp_2:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Metabolism of Terpenoids and Polyketides:Xenobiotics Biodegradation and Metabolism:Genetic Information Processing:Replication and Repair:Global:Metabolism:Regulatory functions:Small molecule interactions:DNA metabolism:DNA replication, recombination, and repair:Cellular processes:Pathogenesis:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 328 "Fructose/tagatose bisphosphate aldolase:Preprotein translocase subunit SecD:Aspartate/tyrosine/aromatic aminotransferase:Branched-chain amino acid ABC-type transport system, permease components:ABC-type branched-chain amino acid transport systems, periplasmic component:Collagenase and related proteases:dTDP-D-glucose 4,6-dehydratase:ABC-type transport system involved in resistance to organic solvents, periplasmic component:Predicted Rossmann fold nucleotide-binding protein:Preprotein translocase subunit YajC:Type II secretory pathway, pseudopilin PulG:Uncharacterized protein related to Endonuclease III:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Posttranslational modification, protein turnover, chaperones:Alanine aspartate and glutamate metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:Tyrosine metabolism:Phenylalanine metabolism:Phenylalanine tyrosine and tryptophan biosynthesis:Novobiocin biosynthesis:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:TIGR00730:yajC:2A0604s01:dTDP_gluc_dehyt:IV_pilin_GFxxxE:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Amino Acid Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein fate:Protein and peptide secretion and trafficking:Hypothetical proteins:Conserved:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 329 "Energy production and conversion:Malic enzyme:Glycosyltransferases involved in cell wall biogenesis:Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases:Exoribonuclease R:rRNA methylases:Nucleoside phosphorylase:Methyl-accepting chemotaxis protein:ATPases involved in chromosome partitioning:Methylase involved in ubiquinone/menaquinone biosynthesis:3-methyladenine DNA glycosylase:Uncharacterized protein conserved in bacteria:Predicted O-methyltransferase:Type II secretory pathway, component HofQ:Cell cycle control, cell division, chromosome partitioning:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Ubiquinone and other terpenoid-quinone biosynthesis:Cysteine and methionine metabolism:Pyruvate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:RNA degradation:Bacterial secretion system:Base excision repair:General function prediction only:Function unknown:Signal transduction mechanisms:rRNA_methyl_3:3_prime_RNase:tag:MenG_MenH_UbiE:Intracellular trafficking, secretion, and vesicular transport:Menaquinone and ubiquinone:Carbohydrate Metabolism:Amino Acid Metabolism:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Replication and Repair:Environmental Information Processing:Membrane Transport:Global:Metabolism:DNA metabolism:DNA replication, recombination, and repair:Transcription:Degradation of RNA:Protein synthesis:tRNA and rRNA base modification:Biosynthesis of cofactors, prosthetic groups, and carriers:Metabolism:Information storage and processing:Cellular processes and signaling:Metabolism:Poorly characterized" 330 "Predicted xylanase/chitin deacetylase:Predicted ATPase or kinase:dTDP-4-dehydrorhamnose reductase:Glycosyltransferases, probably involved in cell wall biogenesis:Predicted inhibitor of MCP methylation, homolog of CheC:Sugar transferases involved in lipopolysaccharide synthesis:Phosphotransferase system, mannose/fructose-specific component IIA:TRAP-type C4-dicarboxylate transport system, small permease component:Carbohydrate transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Fructose and mannose metabolism:Amino sugar and nucleotide sugar metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Phosphotransferase system (PTS):General function prediction only:HI0065_YjeE:EPS_sugtrans:Unknown function:Carbohydrate Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Environmental Information Processing:Membrane Transport:Global:Metabolism:Metabolism:Enzymes of unknown specificity:Cellular processes and signaling:Metabolism:Poorly characterized" 331 "Energy production and conversion:ABC-type Co2+ transport system, permease component:ATPases involved in chromosome partitioning:Superfamily II DNA and RNA helicases:ABC-type cobalt transport system, permease component CbiQ and related transporters:Arsenite efflux pump ACR3 and related permeases:NifU homolog involved in Fe-S cluster formation:Sugar phosphate isomerases/epimerases:Glycosyltransferases, probably involved in cell wall biogenesis:FOG: GGDEF domain:Nitrate/nitrite transporter:Rhodanese-related sulfurtransferase:Uncharacterized protein conserved in bacteria, putative lipoprotein:Cell cycle control, cell division, chromosome partitioning:Carbohydrate transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Inorganic ion transport and metabolism:Metabolic pathways:ABC transporters:RNA degradation:Function unknown:Signal transduction mechanisms:GGDEF:CbiQ_TIGR:HpnI:Membrane Transport:Environmental Information Processing:Cellular processes and signaling:Folding Sorting and Degradation:Metabolism:Poorly characterized:Information storage and processing:Genetic Information Processing:Other:Signal transduction:Cations and iron carrying compounds:Transport and binding proteins:Metabolism:Global" 332 "Energy production and conversion:Arginyl-tRNA synthetase:Signal recognition particle GTPase:Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily:Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase:GTPase SAR1 and related small G proteins:Rubrerythrin:Chorismate mutase:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Phenylalanine tyrosine and tryptophan biosynthesis:Lipopolysaccharide biosynthesis:Aminoacyl-tRNA biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Protein export:Bacterial secretion system:General function prediction only:ftsY:argS:lipid_A_lpxA:IV_pilin_GFxxxE:Intracellular trafficking, secretion, and vesicular transport:Information storage and processing:Amino Acid Metabolism:Glycan Biosynthesis and Metabolism:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein synthesis:tRNA aminoacylation:Protein fate:Protein and peptide secretion and trafficking:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Metabolism:Cellular processes and signaling:Metabolism:Poorly characterized" 333 "Energy production and conversion:Undecaprenyl pyrophosphate synthase:tRNA-dihydrouridine synthase:Ribosomal protein S2:Preprotein translocase subunit SecY:Asparagine synthase (glutamine-hydrolyzing):Glycosyltransferase:Predicted permeases:1-deoxy-D-xylulose 5-phosphate reductoisomerase:dTDP-glucose pyrophosphorylase:Rubrerythrin:Fe-S oxidoreductase, related to NifB/MoaA family:Predicted ATPase related to phosphate starvation-inducible protein PhoH:Pyruvate-formate lyase:Acyl dehydratase:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Uncharacterized protein conserved in bacteria:Uncharacterized conserved protein:Amino acid transport and metabolism:Lipid transport and metabolism:Translation, ribosomal structure and biogenesis:Cell wall/membrane/envelope biogenesis:Alanine aspartate and glutamate metabolism:Streptomycin biosynthesis:Polyketide sugar unit biosynthesis:Pyruvate metabolism:Propanoate metabolism:Butanoate metabolism:Terpenoid backbone biosynthesis:Nitrogen metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Ribosome:Protein export:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Function unknown:Signal transduction mechanisms:uppS:Dxr:nifR3_yhdG:3a0501s007:rpsB_bact:rmlA:asn_synth_AEB:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Carbohydrate Metabolism:Energy Metabolism:Amino Acid Metabolism:Metabolism of Terpenoids and Polyketides:Biosynthesis of Other Secondary Metabolites:Genetic Information Processing:Translation:Folding Sorting and Degradation:Environmental Information Processing:Membrane Transport:Global:Metabolism:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein and peptide secretion and trafficking:Unknown function:General:Amino acid biosynthesis:Aspartate family:Biosynthesis of cofactors, prosthetic groups, and carriers:Other:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Metabolism:Metabolism:Poorly characterized" 334 "Energy production and conversion:Dihydrodipicolinate reductase:Ribose 5-phosphate isomerase RpiB:N6-adenine-specific methylase:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase:Rubrerythrin:Chorismate mutase:Uncharacterized protein, possibly involved in aromatic compounds catabolism:Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB:Uncharacterized conserved protein:Type II secretory pathway, component PulK:Type II secretory pathway, component ExeA (predicted ATPase):Type II secretory pathway, component PulJ:Amino acid transport and metabolism:Carbohydrate transport and metabolism:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Cell motility:Pentose phosphate pathway:Lysine biosynthesis:Phenylalanine tyrosine and tryptophan biosynthesis:Lipopolysaccharide biosynthesis:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Bacterial secretion system:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:dapB:TIGR00095:HDIG:unchar_dom_1:rpiB_lacA_lacB:typeII_sec_gspL:lipid_A_lpxD:type_II_gspE:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Metabolism:Metabolism:Global:Membrane Transport:Environmental Information Processing:Glycan Biosynthesis and Metabolism:Amino Acid Metabolism:Protein synthesis:Carbohydrate Metabolism:tRNA and rRNA base modification:Protein fate:Protein and peptide secretion and trafficking:Cellular processes:Pathogenesis:Amino acid biosynthesis:Aspartate family:Cell envelope:Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides:Information storage and processing:Cellular processes and signaling:Metabolism" 335 "Energy production and conversion:rRNA methylase:Signal transduction histidine kinase:Ni,Fe-hydrogenase maturation factor:Uncharacterized homolog of plant Iojap protein:Transcription termination factor:ATPases involved in chromosome partitioning:Outer membrane protein:Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain):Pyridoxal phosphate biosynthesis protein:FOG: GGDEF domain:Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains:Transposase and inactivated derivatives:UTP:GlnB (protein PII) uridylyltransferase:Selenocysteine-specific translation elongation factor:Uncharacterized protein conserved in bacteria:Predicted transcriptional regulator:Cell cycle control, cell division, chromosome partitioning:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Transcription:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Vitamin B6 metabolism:Porphyrin and chlorophyll metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Two-component system:RNA degradation:Function unknown:Signal transduction mechanisms:rRNA_methyl_1:iojap_ybeB:small_GTP:GGDEF:pdxA:rho:cysG_Nterm:UTase_glnD:MJ0042_CXXC:PEP_resp_reg:PEP_his_kin:Intracellular trafficking, secretion, and vesicular transport:Poorly characterized:Metabolism of Cofactors and Vitamins:Genetic Information Processing:Folding Sorting and Degradation:Environmental Information Processing:Signal Transduction:Global:Metabolism:Regulatory functions:DNA interactions:Protein interactions:Transcription:Transcription factors:Protein synthesis:tRNA and rRNA base modification:Unknown function:General:Biosynthesis of cofactors, prosthetic groups, and carriers:Heme, porphyrin, and cobalamin:Pyridoxine:Signal transduction:Two-component systems:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 336 "Energy production and conversion:tRNA and rRNA cytosine-C5-methylases:N-formylmethionyl-tRNA deformylase:Protein-tyrosine-phosphatase:Zn-dependent protease with chaperone function:ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member:FOG: CheY-like receiver:NADH:ubiquinone oxidoreductase subunit 2 (chain N):NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit:Pyruvate-formate lyase-activating enzyme:N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains):Uncharacterized protein predicted to be involved in DNA repair:Uncharacterized conserved protein:DNA polymerase III, gamma/tau subunits:Ornithine/acetylornithine aminotransferase:Amino acid transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Oxidative phosphorylation:Purine metabolism:Pyrimidine metabolism:Arginine and proline metabolism:Amino sugar and nucleotide sugar metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:DNA replication:Mismatch repair:Homologous recombination:Function unknown:Signal transduction mechanisms:pept_deformyl:cas1:rsmB:holB:argD:recD:NDH_I_N:NDH_I_L:Poorly characterized:Carbohydrate Metabolism:Energy Metabolism:Nucleotide Metabolism:Amino Acid Metabolism:Genetic Information Processing:Replication and Repair:Global:Metabolism:Energy metabolism:Electron transport:DNA metabolism:DNA replication, recombination, and repair:Protein synthesis:tRNA and rRNA base modification:Protein fate:Protein modification and repair:Mobile and extrachromosomal element functions:Other:Information storage and processing:Cellular processes and signaling:Metabolism:Metabolism" 337 "Energy production and conversion:3-oxoacyl-(acyl-carrier-protein) synthase:Nitroreductase:Methyl-accepting chemotaxis protein:Membrane-fusion protein:Flagellar motor protein:Outer membrane protein:Uncharacterized conserved protein:Coenzyme F420-reducing hydrogenase, gamma subunit:Putative silver efflux pump:Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain:Signal transduction histidine kinase:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Cell motility:Inorganic ion transport and metabolism:Fatty acid biosynthesis:Metabolic pathways:Two-component system:Bacterial chemotaxis:Flagellar assembly:Secondary metabolites biosynthesis, transport and catabolism:Function unknown:Signal transduction mechanisms:sensory_box:2A0601:RND_mfp:antibiot_sagB:Intracellular trafficking, secretion, and vesicular transport:Cellular processes and signaling:Lipid Metabolism:Environmental Information Processing:Signal Transduction:Cellular Processes:Cell Motility:Global:Metabolism:Regulatory functions:Small molecule interactions:Transport and binding proteins:Unknown substrate:Cations and iron carrying compounds:Metabolism:Metabolism:Poorly characterized" 338 "Purine nucleoside phosphorylase:FAD synthase:Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A):Predicted GTPase:Phosphoglycerate mutase 1:FOG: CheY-like receiver:Predicted permeases:Sec-independent protein secretion pathway component TatC:Cation/multidrug efflux pump:ABC-type dipeptide/oligopeptide/nickel transport systems, permease components:Predicted glycosyltransferases:Putative threonine efflux protein:Methylase of chemotaxis methyl-accepting proteins:HrpA-like helicases:Transposase and inactivated derivatives:Uncharacterized protein conserved in bacteria:FOG: GGDEF domain:Uncharacterized conserved protein:Uncharacterized protein conserved in bacteria:Selenocysteine-specific translation elongation factor:Predicted restriction endonuclease:Signal transduction histidine kinase, nitrogen specific:Predicted permease, DMT superfamily:Amino acid transport and metabolism:Nucleotide transport and metabolism:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Translation, ribosomal structure and biogenesis:Replication, recombination and repair:Cell motility:Inorganic ion transport and metabolism:Glycolysis / Gluconeogenesis:Cysteine and methionine metabolism:Methane metabolism:Riboflavin metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:ABC transporters:Two-component system:Bacterial chemotaxis:Protein export:Bacterial secretion system:General function prediction only:Function unknown:Signal transduction mechanisms:efp:ribF:small_GTP:GGDEF:tatC:pgm_1:MTAP:DEAH_box_HrpB:Intracellular trafficking, secretion, and vesicular transport:Defense mechanisms:Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Information storage and processing:Other:Signal transduction:Riboflavin, FMN, and FAD:Biosynthesis of cofactors, prosthetic groups, and carriers:General:Enzymes of unknown specificity:Unknown function:Protein and peptide secretion and trafficking:Protein fate:Translation factors:Protein synthesis:Salvage of nucleosides and nucleotides:Purines, pyrimidines, nucleosides, and nucleotides:Metabolism:Global:Cell Motility:Cellular Processes:Signal Transduction:Membrane Transport:Environmental Information Processing:Folding Sorting and Degradation:Genetic Information Processing:Metabolism of Cofactors and Vitamins:Amino Acid Metabolism:Energy Metabolism:Carbohydrate Metabolism" 339 "Energy production and conversion:Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2:Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes:Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases):ADP-ribosylglycohydrolase:DnaK suppressor protein:Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family:Glucose/sorbosone dehydrogenases:Aldehyde:ferredoxin oxidoreductase:Opacity protein and related surface antigens:Signal transduction histidine kinase:Carbohydrate transport and metabolism:Coenzyme transport and metabolism:Lipid transport and metabolism:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Glycolysis / Gluconeogenesis:Citrate cycle (TCA cycle):Pentose phosphate pathway:Pyruvate metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Microbial metabolism in diverse environments:Secondary metabolites biosynthesis, transport and catabolism:General function prediction only:Signal transduction mechanisms:sensory_box:Carbohydrate Metabolism:Poorly characterized:Metabolism:Cellular processes and signaling:Small molecule interactions:Regulatory functions:Metabolism:Global:Metabolism" 340 "Methionine aminopeptidase:Ribosomal protein L4:Ribosomal protein L23:Ribosomal protein L22:Ribosomal protein S3:Ribosomal protein L14:Ribosomal protein S8:Ribosomal protein L6P/L9E:Ribosomal protein S5:Ribosomal protein S19:Ribosomal protein S17:Ribosomal protein L16/L10E:Ribosomal protein L24:Ribosomal protein S14:Ribosomal protein L17:Ribosomal protein L28:Ribosomal protein L29:Adenylate kinase and related kinases:Ribosomal protein L30/L7E:Nucleotide transport and metabolism:Translation, ribosomal structure and biogenesis:Purine metabolism:Metabolic pathways:Biosynthesis of secondary metabolites:Ribosome:L28:L29:L17:met_pdase_I:rpsC_bact:rpsE_bact:rplV_bact:rpsS_bact:rplN_bact:rplX_bact:rplP_bact:rpmD_bact:adk:S17_bact:L6_bact:rplD_bact:Metabolism:Nucleotide Metabolism:Genetic Information Processing:Translation:Global:Metabolism:Purines, pyrimidines, nucleosides, and nucleotides:Nucleotide and nucleoside interconversions:Protein synthesis:Ribosomal proteins: synthesis and modification:Protein fate:Protein modification and repair:Information storage and processing:Metabolism" 341 "Membrane-fusion protein:ABC-type antimicrobial peptide transport system, ATPase component:Putative silver efflux pump:Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains:Signal transduction histidine kinase regulating C4-dicarboxylate transport system:Cytochrome c biogenesis factor:Predicted spermidine synthase with an N-terminal membrane domain:Uncharacterized protein conserved in bacteria:ABC-type transport system, involved in lipoprotein release, permease component:Transcription:Cell wall/membrane/envelope biogenesis:Posttranslational modification, protein turnover, chaperones:Inorganic ion transport and metabolism:Cysteine and methionine metabolism:Arginine and proline metabolism:beta-Alanine metabolism:Glutathione metabolism:Metabolic pathways:Two-component system:General function prediction only:Function unknown:Signal transduction mechanisms:2A0601:RND_mfp:Defense mechanisms:Cellular processes and signaling:Amino Acid Metabolism:Metabolism of Other Amino Acids:Environmental Information Processing:Signal Transduction:Global:Metabolism:Transport and binding proteins:Unknown substrate:Cations and iron carrying compounds:Information storage and processing:Metabolism:Metabolism:Poorly characterized"