GO:0003918

DNA topoisomerase type II (ATP-hydrolyzing) activity

Details: 
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. [PMID:8811192]
Evidence Code: