GO:0004421

hydroxymethylglutaryl-CoA synthase activity

Details: 
Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+). [EC:2.3.3.10, RHEA:10191]
Evidence Code: 
IEA