18294-GO
Gene ID:
oxidized purine nucleobase lesion DNA N-glycosylase activity
Details:
Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. [GOC:elh, PMID:11554296]
Evidence Code: