GO:0046934

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Details: 
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). [EC:2.7.1.153, RHEA:21295]
Evidence Code: