Tek endothelial-specific receptor tyrosine kinase (21687) | Macrophage Network Portal

Summary

	Symbol	Product	Feature Type	Strand	Chr
21687	Tek	endothelial-specific receptor tyrosine kinase	protein-coding		4

Synonyms

Synonyms
AA517024 \| Cd202b \| Hyk \| Tie2 \| tie-2

DB XRef

Ensembl	MGI	VEGA
ENSMUSG00000006386	MGI:98664	OTTMUSG00000007859

GO Terms

GO ID	Category	Definition	Evidence
GO:0000166 GO:0001525 GO:0001569 GO:0001570 GO:0001725 GO:0001934 GO:0001935 GO:0001936 GO:0002040 GO:0004672 GO:0004713 GO:0004714 GO:0004872 GO:0005515 GO:0005524 GO:0005576 GO:0005737 GO:0005856 GO:0005884 GO:0005886 GO:0005887 GO:0005902 GO:0005911 GO:0006468 GO:0007160 GO:0007169 GO:0007507 GO:0009925 GO:0009986 GO:0010595 GO:0014068 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016323 GO:0016324 GO:0016337 GO:0016525 GO:0016740 GO:0016772 GO:0018108 GO:0019838 GO:0030054 GO:0030097 GO:0030334 GO:0030949 GO:0032526 GO:0032878 GO:0033138 GO:0034446 GO:0035556 GO:0043066 GO:0043552 GO:0043627 GO:0045121 GO:0045765 GO:0045766 GO:0045785 GO:0046777 GO:0048014 GO:0051259 GO:0051894 GO:0051897 GO:0060347 GO:0070374 GO:1902533 GO:2000251 GO:2000352	Function Process Component	nucleotide binding angiogenesis patterning of blood vessels vasculogenesis stress fiber positive regulation of protein phosphorylation endothelial cell proliferation regulation of endothelial cell proliferation sprouting angiogenesis protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor activity protein binding ATP binding extracellular region cytoplasm cytoskeleton actin filament plasma membrane integral component of plasma membrane microvillus cell-cell junction protein phosphorylation cell-matrix adhesion transmembrane receptor protein tyrosine kinase signaling pathway heart development basal plasma membrane cell surface positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane kinase activity phosphorylation basolateral plasma membrane apical plasma membrane cell-cell adhesion negative regulation of angiogenesis transferase activity transferase activity, transferring phosphorus-containing groups peptidyl-tyrosine phosphorylation growth factor binding cell junction hemopoiesis regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway response to retinoic acid regulation of establishment or maintenance of cell polarity positive regulation of peptidyl-serine phosphorylation substrate adhesion-dependent cell spreading intracellular signal transduction negative regulation of apoptotic process positive regulation of phosphatidylinositol 3-kinase activity response to estrogen membrane raft regulation of angiogenesis positive regulation of angiogenesis positive regulation of cell adhesion protein autophosphorylation Tie signaling pathway protein oligomerization positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling heart trabecula formation positive regulation of ERK1 and ERK2 cascade positive regulation of intracellular signal transduction positive regulation of actin cytoskeleton reorganization negative regulation of endothelial cell apoptotic process	IEA IMP TAS ISO IDA IPI ISM IGI

Regulatory Modules

	Motif 1	Motif 2	Residual

Regulation

Displaying 1 - 1 of 1

Regulator Locus	Interaction	Weight

String Network

Entrez ID	STRINGS Network
STRING

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