GO:0036317

Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from virion RNA prior to its engaging in protein synthesis. [GOC:bf, GOC:sp, PMID:21408223, PMID:22908287]