56187-GO
Gene ID:
Rab geranylgeranyltransferase activity
Details:
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. [EC:2.5.1.60, GOC:mah, PMID:8621375]
Evidence Code: