Rv0757 DNA-binding response regulator

Rv0757 (DNA-binding response regulator) is predicted to be co-regulated in modules bicluster_0144 with residual 0.61 and bicluster_0543 with residual 0.58.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.02 and 13.00 for bicluster_0144 and 0.00 and 0.00 for bicluster_0543 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Displaying 71 - 80 of 96
Gene Target Differential Expression Distance Expression pvalue Type
Transcriptional regulator, AsnC family
Induced 35 1.87 0.000000000000161 Internal.TSS
Alanine dehydrogenase (EC 1.4.1.1)
Repressed -52 -0.74 0.0153993 Primary.TSS
LSU ribosomal protein L19p
No 53 -0.57 0.0000568 Primary.TSS
Putative lipoprotein lppW precursor
Induced -47 0.84 0.00000000000017 Primary.TSS
2,5-diketo-D-gluconic acid reductase (EC 1.1.1.-)
No -35 -0.34 0.0528142 Primary.TSS
NADH-ubiquinone oxidoreductase chain L (EC 1.6.5.3)
No 59 0.12 0.606233 Internal.TSS
No -15 0.04 0.930229 Primary.TSS
Ubiquinone biosynthesis monooxygenase UbiB
Induced -10 1.59 1.8e-36 CDS
Ubiquinone biosynthesis monooxygenase UbiB
Induced -15 1.59 1.8e-36 Antisense.TSS
Ubiquinone biosynthesis monooxygenase UbiB
Induced -25 1.59 1.8e-36 Internal.TSS
not assigned to any KEGG Pathway.
GO:0008150

biological_process

biological_process

Details: 
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO Category: 
biological_process
66
Total items in this category:  
GO:0008150

biological_process

biological_process

Details: 
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO Category: 
biological_process
66
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0006979

response to oxidative stress

response to oxidative stress

Details: 
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
GO Category: 
biological_process
13
Total items in this category:  
GO:0009247

glycolipid biosynthetic process

glycolipid biosynthetic process

Details: 
The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
GO Category: 
biological_process
17
Total items in this category:  
GO:0009405

pathogenesis

pathogenesis

Details: 
The set of specific processes that generate the ability of an organism to cause disease in another.
GO Category: 
biological_process
65
Total items in this category:  
GO:0045892

negative regulation of transcription, DNA-dependent

negative regulation of transcription, DNA-dependent

Details: 
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-dependent transcription.
GO Category: 
biological_process
10
Total items in this category:  
GO:0045893

positive regulation of transcription, DNA-dependent

positive regulation of transcription, DNA-dependent

Details: 
Any process that activates or increases the frequency, rate or extent of cellular DNA-dependent transcription.
GO Category: 
biological_process
14
Total items in this category:  
No TFOE experiment results were found

TRIP log2 fold abundance change

NA
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D28I 4 28 30.61 14.27 I
D28U 4 28 30.61 12.71 U
D24I 3 24 26.60 14.59 I
D24U 3 24 26.60 12.65 U
D21I 4 21 23.23 14.04 I
D21U 4 21 23.23 12.81 U
D17I 3 17 19.15 14.21 I
D17U 3 17 19.15 12.79 U
D14I 4 14 15.63 13.81 I
D14U 4 14 15.63 13.00 U
D7I 18 7 8.14 13.74 I
D7U 19 7 8.14 13.58 U
D5I 9 5 6.00 14.03 I
D5U 17 5 6.00 13.83 U
D3I 3 3 3.83 13.88 I
D3U 3 3 3.83 13.53 U
D0U 27 0 0.00 13.70 U