Genes

Genes page will display table of Mycobacterium tuberculosis H37Rv genes. Genome annotations are mainly derived from Tuberculist . Locus name is linked to individual gene pages that include more detailed information. Various filters can be used to pinpoint gene of interest.

Table Columns

• Locus: Locus tag of the gene linked to detailed gene page
• Symbol: Gene Symbol if available.
• Cholesterol Essential: Indicates if the gene is found to be essential for in vitro growth on Cholesterol.
  Reference:Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM, High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog (2011) 7(9):e1002251
• Griffin Essential: Essentiality score of in vitro growth.
  Reference:Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM, High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog (2011) 7(9):e1002251
• Bound by: This column will list number of TF(s) that were found to bind to upstream of the given gene in ChIP-Seq experiments.
  Reference: Minch KJ, Rustad TR, Peterson EJR, et al. "The DNA-binding network of Mycobacterium tuberculosis." Nat Commun. 2015;6:5829
• Binds To: If the gene is a TF, this column will list number of target genes that it binds to as identified in ChIP-Seq experiments.
  Reference: Minch KJ, Rustad TR, Peterson EJR, et al. "The DNA-binding network of Mycobacterium tuberculosis." Nat Commun. 2015;6:5829

Filters:

Genes table can be further filtered by number of criteria. Multiple filters can be combined to create more specific queries. Sorting can also be changed based on different parameters. Simply select filters you want to apply, select sorting method and press "Apply".

Reference: Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM, High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog (2011) 7(9):e1002251

Reference: Minch KJ, Rustad TR, Peterson EJR, et al. "The DNA-binding network of Mycobacterium tuberculosis." Nat Commun. 2015;6:5829