-- dump date   	20110422_075815
-- class       	Genbank::Feature
-- table       	feature
-- table       	main
-- field 1	id
-- field 2	type
-- field 3	name
-- field 4	contig
-- field 5	start_pos
-- field 6	end_pos
-- field 7	strand
-- field 8	description
-- field 9	chrom_position
-- field 10	organism
-- field 11	GeneID
-- header
-- id	type	name	contig	start_pos	end_pos	strand	description	chrom_position	organism	GeneID
83332000001	SEQ_END	SEQ_END	NC_000962.2	4411532	4411532	DR	NC_000962.2; contig end	4411532..4411532	Mycobacterium tuberculosis H37Rv	<NULL_VALUE>
NP_214515.1	CDS	dnaA	NC_000962.2	1	1524	D	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein	1..1524	Mycobacterium tuberculosis H37Rv	885041
NP_214516.1	CDS	dnaN	NC_000962.2	2052	3260	D	binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta	2052..3260	Mycobacterium tuberculosis H37Rv	887092
NP_214517.1	CDS	recF	NC_000962.2	3280	4437	D	Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F	3280..4437	Mycobacterium tuberculosis H37Rv	887089
NP_214518.1	CDS	Rv0004	NC_000962.2	4434	4997	D	Rv0004, (MTCY10H4.02), len: 187 aa. Conserved hypothetical protein (see Salazar et al., 1996), highly similar, but longer 21 aa in N-terminus, to AAF33696.1|AF222789 unknown protein from Mycobacterium avium subsp. paratuberculosis (166 aa); and highly similar to NP_301132.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (189 aa); S70990 hypothetical protein from Mycobacterium smegmatis (194 aa). Also highly similar, except in N-terminal part, to NP_599256.1|NC_003450 conserved hypothetical protein from Corynebacterium glutamicum (178 aa), 47.0% identity. Also very weakly similar in C-terminus to C-terminal part of P35925|YREG_STRCO HYPOTHETICAL 19.8 KDA PROTEIN (IN RECF-GYRB INTERGENIC REGION) from Streptomyces coelicolor (190 aa), FASTA scores: opt: 404, E(): 3.9e-18, (40.7% identity in 189 aa overlap).; hypothetical protein	4434..4997	Mycobacterium tuberculosis H37Rv	887088
NP_214519.1	CDS	gyrB	NC_000962.2	5123	7267	D	negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B	5123..7267	Mycobacterium tuberculosis H37Rv	887081
NP_214520.1	CDS	gyrA	NC_000962.2	7302	9818	D	negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A	7302..9818	Mycobacterium tuberculosis H37Rv	887105
NP_214521.1	CDS	Rv0007	NC_000962.2	9914	10828	D	Rv0007, (MTCY10H4.05), len: 304 aa. Possible conserved membrane protein, highly similar to Z70722|MLCB1770_7 from Mycobacterium leprae (303 aa), FASTA scores: opt: 812, E(): 1.6e-25, (54.2% identity in 319 aa overlap). C-terminal part highly similar to C-terminus of CAB92992.1|AL357152 putative integral membrane protein from Streptomyces coelicolor (185 aa); and N-terminal part highly similar to C-terminus of NP_302684.1|NC_002677 hypothetical protein from Mycobacterium leprae (123 aa).; hypothetical protein	9914..10828	Mycobacterium tuberculosis H37Rv	885982
NP_214522.1	CDS	Rv0008c	NC_000962.2	11874	12311	R	Rv0008c, (MTCY10H4.07c), len: 145 aa. Possible membrane protein.; hypothetical protein	complement(11874..12311)	Mycobacterium tuberculosis H37Rv	887085
NP_214523.1	CDS	ppiA	NC_000962.2	12468	13016	D	Rv0009, (MTCY10H4.08), len: 182. Probable ppiA (alternate gene name: cfp22), iron-regulated peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8), equivalent to NP_301138.1|NC_002677 putative peptidyl-prolyl cis-trans isomerase from Mycobacterium leprae (182 aa), FASTA score: (90.1% identity in 182 aa overlap). Also highly similar to others e.g. T36725 from Streptomyces coelicolor (177 aa); T43805 from Halobacterium salinarum (180 aa); NP_219383.1|NC_000919 from Treponema pallidum (215 aa); etc. BELONGS TO THE CYCLOPHILIN-TYPE PPIASE FAMILY. Alternative start codon has been suggested.; cfp22; iron-regulated peptidyl-prolyl cis-trans isomerase A	12468..13016	Mycobacterium tuberculosis H37Rv	887087
NP_214524.1	CDS	Rv0010c	NC_000962.2	13133	13558	R	Rv0010c, (MTCY10H4.10c), len: 141 aa. Probable conserved membrane protein, equivalent to NP_301139.1|NC_002677 putative membrane protein from Mycobacterium leprae (137 aa); and similar to Rv1417|P71686|YE17_MYCTU HYPOTHETICAL 16.4 kDa PROTEIN from Mycobacterium tuberculosis (154 aa), FASTA scores: opt: 121, E(): 0.097, (29.6% identity in 81 aa overlap).; hypothetical protein	complement(13133..13558)	Mycobacterium tuberculosis H37Rv	887082
NP_214525.1	CDS	Rv0011c	NC_000962.2	13714	13995	R	integral membrane protein involved in inhibition of the Z-ring formation; putative septation inhibitor protein	complement(13714..13995)	Mycobacterium tuberculosis H37Rv	887074
NP_214526.1	CDS	Rv0012	NC_000962.2	14089	14877	D	Rv0012, (MTCY10H4.12), len: 262 aa. Probable conserved membrane protein, similar to AL079308|SCH69_23|T36722 hypothetical protein from Streptomyces coelicolor (237 aa), FASTA scores: opt: 506, E(): 1.9e-25, (39.8% identity in 236 aa overlap). Some similarity to BLU0|1958_35A2 DIVIB (fragment) (188 aa), FASTA scores: opt: 204, E(): 8.9e-07, (35.6% identity in 90 aa overlap); and G1129091|DDS cell division and sporulation protein from Bacillus subtilis (231 aa), FASTA scores: opt: 180, E(): 3.8e-05, (30.7% identity in 101 aa overlap). Also similar to Rv1823|MTCY1A11_20 from Mycobacterium tuberculosis FASTA score: (30.1% identity in 246 aa overlap); and MTCY1A11_18 FASTA score: (25.5% identity in 235 aa overlap). Contains probable N-terminal signal sequence.; hypothetical protein	14089..14877	Mycobacterium tuberculosis H37Rv	887083
YP_177615.1	CDS	trpG	NC_000962.2	14914	15612	D	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II	14914..15612	Mycobacterium tuberculosis H37Rv	885955
NP_214528.1	CDS	pknB	NC_000962.2	15590	17470	R	Rv0014c, (MTCY10H4.14c), len: 626 aa. pknB, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), equivalent to MLCB1770_9|T10009 probable serine/threonine-specific protein kinase from Mycobacterium leprae (622 aa), FASTA scores: opt: 3600, E(): 0, (86.4% identity in 626 aa overlap). Also similar (highly similar in N-terminus) to others e.g. T36717 from Streptomyces coelicolor (673 aa); NP_389459.1|NC_000964 from Bacillus subtilis (648 aa); NP_465345.1|NC_003210 from Listeria monocytogenes (655 aa); E235741 protein kinase pknB (315 aa), FASTA scores: opt: 1839, E(): 0, (90.8 identity in 305 aa overlap); etc. Contains PS00107 Protein kinases ATP-binding region signature, and PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on serine/threonine residues.; transmembrane serine/threonine-protein kinase B PKNB (protein kinase B) (STPK B)	complement(15590..17470)	Mycobacterium tuberculosis H37Rv	887072
NP_214529.1	CDS	pknA	NC_000962.2	17467	18762	R	Rv0015c, (MTCY10H4.15c), len: 431 aa. pknA, transmembrane serine/threonine-protein kinase (EC 2.7.1.-), magnesium/manganese dependent (see citations below), equivalent to MLCB1770_10|NP_301143.1|NC_002677 putative serine/threonine protein kinase from Mycobacterium leprae (437 aa), FASTA scores: opt: 1883, E(): 0, (72.1% identity in 434 aa overlap). And also highly similar to other kinases from Mycobacterium leprae e.g. MLCB1770_10 from Mycobacterium leprae (437 aa). Also similar to PKNA_MYCLE protein kinase (253 aa), FASTA scores: opt: 1525, E(): 0, (95.0% identity in 242 aa overlap); etc. Also highly similar in part to others e.g. N-terminus of NP_243370.1|NC_002570 from Bacillus halodurans (664 aa); N-terminus of T36717 from Streptomyces coelicolor (673 aa); etc. Also similar to others from Mycobacterium tuberculosis: MTCY10H4_15, MTV021_9, MTCY28_5, MTCY4C12_28, MTCY50_16, MTCY8D9_8, MTCY49_28, MTCY4C12_30, MTCY28_9, etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. It has been shown that sodium orthovanadate inhibits the activity of the enzyme in vitro.; transmembrane serine/threonine-protein kinase A PKNA (protein kinase A) (STPK A)	complement(17467..18762)	Mycobacterium tuberculosis H37Rv	885953
NP_214530.1	CDS	pbpA	NC_000962.2	18759	20234	R	Rv0016c, (MTCY10H4.16c), len: 491 aa. Probable pbpA, penicillin-binding protein, equivalent to NP_301144.1|NC_002677 putative penicillin-binding protein from Mycobacterium leprae (492 aa); and highly similar to MLCB1770_1 penicillin binding protein from Mycobacterium leprae (474 aa), FASTA scores: opt: 2516, E(): 0, (82.4% identity in 472 aa overlap). Also similar to others e.g. T36716 from Streptomyces coelicolor (490 aa); AAF61246.1|AF241575|PbpA from Streptomyces griseus (485 aa); NP_347146.1|NC_003030 from Clostridium acetobutylicum (482 aa); E235825|pbpA penicillin binding protein (325 aa), FASTA scores: opt: 1618, E(): 0, (78.3% identity in 323 aa overlap); etc. And also similar to MTCY270_5 and MTV003_8 from Mycobacterium tuberculosis.; penicillin-binding protein PbpA	complement(18759..20234)	Mycobacterium tuberculosis H37Rv	887078
NP_214531.1	CDS	rodA	NC_000962.2	20231	21640	R	Rv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA (alternate gene name: ftsW), cell division protein, integral membrane protein, equivalent to MLCB1770_12|T10012 probable cell division protein from Mycobacterium leprae (465 aa), FASTA scores: opt: 2475, E(): 0, (81.9% identity in 469 aa overlap). Also highly similar to others e.g. T36715|SCH69.16 from Streptomyces coelicolor (479 aa); NP_243432.1|NC_002570 from Bacillus halodurans (366 aa); NP_347145.1|NC_003030 from Clostridium acetobutylicum (400 aa); etc. Also similar to MTCY270_14 from Mycobacterium tuberculosis FASTA score: (32.2% identity in 369 aa overlap). BELONGS TO THE FTSW/RODA/SPOVE FAMILY.; ftsW; cell division protein RodA	complement(20231..21640)	Mycobacterium tuberculosis H37Rv	887075
NP_214532.1	CDS	ppp	NC_000962.2	21637	23181	R	Rv0018c, (MTCY10H4.18c), len: 514 aa. Possible ppp, serine/threonine phosphatase (EC 3.1.3.16), equivalent to MLCB1770_13|T10013 PUTATIVE PHOSPHOPROTEIN PHOSPHATASE from Mycobacterium leprae (509 aa), FASTA scores: opt: 2517, E(): 0. Also highly similar to others e.g. T36714 probable protein phosphatase from Streptomyces coelicolor (515 aa); CAA10712.1|AJ132604 pppL protein from Lactococcus lactis (258 aa); NP_248765.1|NC_002516 probable phosphoprotein phosphatase from Pseudomonas aeruginosa (242 aa); etc. Also similar to BSUB0009_46 YLOO PROTEIN from Bacillus subtilis (254 aa), FASTA score: (34.0% identity in 250 aa overlap).; serine/threonine phosphatase	complement(21637..23181)	Mycobacterium tuberculosis H37Rv	887070
NP_214533.1	CDS	Rv0019c	NC_000962.2	23270	23737	R	Rv0019c, (MTCY10H4.19c), len: 155 aa. Conserved hypothetical protein, equivalent to MLCB1770_14|NP_301147.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (155 aa), FASTA scores: opt: 902, E(): 0, (91.0% identity in 155 aa overlap). Also highly similar to T36713|AL079308|SCH69_14 from Streptomyces coelicolor (172 aa), FASTA scores: opt: 389, E(): 6e-21, (46.2% identity in 171 aa overlap); and similar in C-terminus to others e.g. NP_342559.1|NC_002754 Conserved hypothetical protein from Sulfolobus solfataricus (209 aa); etc. C-terminus also highly similar to C-terminal part of AAF07901.1|AF173844_2|AF173844 putative signal transduction protein GarA from Mycobacterium smegmatis (158 aa). Also similar to Rv1827|MTCY 1A11.16c from Mycobacterium tuberculosis ( 162 aa), FASTA score: (41.2% identity in 85 aa overlap); MTMOAIS_3; MAU66560_1 and MLCB1788_15.; hypothetical protein	complement(23270..23737)	Mycobacterium tuberculosis H37Rv	887079
NP_214534.1	CDS	TB39.8	NC_000962.2	23861	25444	R	Rv0020c, (MTCY10H4.20c), len: 527 aa. TB39.8, conserved hypothetical protein, identified by proteomic study by the Statens Serum Institute, Denmark (spot TB39.8) (see citation below). Highly similar to NP_301148.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (488 aa); and Z70722|MLCB1770_15|T10015 hypothetical protein from Mycobacterium leprae (463 aa), FASTA scores: opt: 1213, E(): 2.2e-32, (72.3% identity in 506 aa overlap). Alternative start codon in position 24979 has been suggested (see citation below).; hypothetical protein	complement(23861..25444)	Mycobacterium tuberculosis H37Rv	887067
NP_214535.1	CDS	Rv0021c	NC_000962.2	25913	26881	R	Rv0021c, (MTCY10H4.21c), len: 322 aa. Conserved hypothetical protein, similar to various proteins e.g. NP_464341.1|NC_003210 protein similar to oxidoreductases from Listeria monocytogenes (309 aa); NP_357973.1|NC_003098 Enoyl-acyl carrier protein(ACP) reductase from Streptococcus pneumoniae (324 aa); 2NPD_NEUCR|G726338 2-nitropropane dioxygenase precursor from Neurospora crassa (378 aa), FASTA scores: opt: 383, E(): 1.1e-16, (32.2% identity in 348 aa overlap); etc. Also similar to AE001747_25 from Thermotoga maritima section 59 (314 aa), FASTA scores: opt: 442, E(): 1.5e-19, (30.5% identity in 325 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv3553 (355 aa), FASTA scores: E(): 6.8e-15, (35.3 identity in 235 aa overlap); and Rv1533 (375 aa), FASTA scores: E(): 4.7e-12, (34.4% identity in 262 aa overlap).; hypothetical protein	complement(25913..26881)	Mycobacterium tuberculosis H37Rv	887066
NP_214536.1	CDS	whiB5	NC_000962.2	27023	27442	R	Rv0022c, (MTCY10H4.22c), len: 139 aa. Probable whiB5 (alternate gene name: whmG), WhiB-like regulatory protein (see citations below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Shows some similarity to O88103|AJ239086|SCO239086_1|WHID|SC6G4.45c|WBLB WHID PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 125, E(): 0.055, (37.1% identity in 97 aa overlap); and slight similarity to G466960|WHIB WHIB PROTEIN (102 aa), FASTA scores: opt: 112, E(): 0.14, (34.3 identity in 67 aa overlap).; whmG; transcriptional regulatory protein WHIB-like WHIB5	complement(27023..27442)	Mycobacterium tuberculosis H37Rv	887071
NP_214537.1	CDS	Rv0023	NC_000962.2	27595	28365	D	Rv0023, (MTCY10H4.23),len: 256 aa. Possible transcriptional regulator, equivalent to CAB96432.1|AJ251434 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (146 aa). N-terminus showing similarity with other transcriptional regulators e.g. AE0002|ECAE000240_9 from Escherichia coli strain K12 (178 aa), FASTA scores: opt: 149, E(): 0.0048, (33.3% identity in 84 aa overlap); etc. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD).; transcriptional regulatory protein	27595..28365	Mycobacterium tuberculosis H37Rv	887062
NP_214538.1	CDS	Rv0024	NC_000962.2	28362	29207	D	Rv0024, (MTCY10H4.24), len: 281 aa. Putative secreted protein, p60 homologue, similar in part to others and relatives proteins e.g. P60_LISIV|Q01837 protein p60 precursor (invasion-associated protein) from Listeria ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 putative NPL/P60 family secreted protein from Streptomyces coelicolor (347 aa) ; etc. Similar to Mycobacterium tuberculosis proteins Rv1477, Rv1478, Rv1566c, Rv2190c. And several homologues in Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517 probable secreted protein (338 aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY.; putative secreted protein P60-related protein	28362..29207	Mycobacterium tuberculosis H37Rv	887061
NP_214539.1	CDS	Rv0025	NC_000962.2	29245	29607	D	Rv0025, (MTCY10H4.25), len: 120 aa. Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. Rv0739 (268 aa), FASTA score: (37.6% identity in 101 aa overlap), and Rv0026 FASTA score: (35.4% identity in 113 aa overlap); etc.; hypothetical protein	29245..29607	Mycobacterium tuberculosis H37Rv	887060
NP_214540.1	CDS	Rv0026	NC_000962.2	29722	31068	D	Rv0026, (MTCY10H4.26), len: 448 aa. Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis: Rv0025 FASTA score: (35.4% identity in 113 aa overlap) and Rv0739 (268 aa), FASTA score: (32.4% identity in 142 aa overlap).; hypothetical protein	29722..31068	Mycobacterium tuberculosis H37Rv	887057
NP_214541.1	CDS	Rv0027	NC_000962.2	31189	31506	D	Rv0027, (MTCY10H4.27), len: 105 aa. Hypothetical unknown protein.; hypothetical protein	31189..31506	Mycobacterium tuberculosis H37Rv	887054
NP_214542.1	CDS	Rv0028	NC_000962.2	31514	31819	D	Rv0028, (MTCY10H4.28), len: 101 aa. Hypothetical unknown protein.; hypothetical protein	31514..31819	Mycobacterium tuberculosis H37Rv	885812
NP_214543.1	CDS	Rv0029	NC_000962.2	32057	33154	D	Rv0029, (MTCY10H4.29), len: 365 aa. Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. C-terminal region of Rv2082|MTCY49_21|E247006 hypothetical 73.6 kDa protein (721 aa), FASTA scores: opt: 453, E(): 1.2e-22, (38.5% identity in 265 aa overlap); Rv3899c|MTY15F10_12 HYPOTHETICAL 40.8 kDa PROTEIN (410 aa), FASTA score: (33.7% identity in 252 aa overlap); etc.; hypothetical protein	32057..33154	Mycobacterium tuberculosis H37Rv	887053
NP_214544.1	CDS	Rv0030	NC_000962.2	33224	33553	D	Rv0030, (MTCY10H4.30), len: 109 aa. Hypothetical unknown protein.; hypothetical protein	33224..33553	Mycobacterium tuberculosis H37Rv	887051
NP_214545.1	CDS	Rv0031	NC_000962.2	33582	33794	D	Rv0031, (MTCY10H4.31), len: 70 aa. Possible remnant of a transposase, showing partial similarity to mycobacterial transposases in a short overlap, e.g. Rv2791c|MTV002_57 (459 aa), FASTA score: (72.2% identity in 36 aa overlap); Rv2885c, Rv2978c, Rv3827c, etc.; remnant of A transposase	33582..33794	Mycobacterium tuberculosis H37Rv	887049
NP_214546.1	CDS	bioF2	NC_000962.2	34295	36610	D	Rv0032, (MTCY10H4.32), len: 771 aa. Probable bioF2, 8-amino-7-oxononanoate synthase (EC 2.3.1.47), with its C-terminal similar to others e.g. BIOF_BACSU|P53556 8-amino-7-oxononanoate synthase from Bacillus subtilis (389 aa), FASTA scores: opt: 775, E(): 0, (37.9% identity in 346 aa overlap); P22806|BIOF_BACSH from Bacillus sphaericus (389 aa); etc. Also similar to BIOF1|Rv1569|MTCY336_35 from Mycobacterium tuberculosis (386 aa), AF041819_4 from Mycobacterium bovis, and BIOF_MYCLE|P45487 from Mycobacterium leprae (385 aa). Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES.; 8-amino-7-oxononanoate synthase BioF2	34295..36610	Mycobacterium tuberculosis H37Rv	887050
NP_214547.1	CDS	acpA	NC_000962.2	36607	36870	D	Rv0033, (MTCY10H4.33), len: 87 aa. Probable acpA (alternate gene name: acpP), acyl carrier protein, similar to others e.g. ACP_BACSU|P80643 acyl carrier protein (acp) from Bacillus subtilis (77 aa), FASTA scores: opt: 149, E(): 0.00026, (41.4% identity in 70 aa overlap); NP_224500.1|NC_000922 Acyl Carrier Protein from Chlamydophila pneumoniae (79 aa); NP_228471.1|NC_000853 acyl carrier protein from Thermotoga maritima (81 aa); etc. Also similar to proteins of Mycobacterium tuberculosis Rv1344 and Rv2244 (31.5% identity in 73 aa overlap).; acpP; acyl carrier protein AcpA	36607..36870	Mycobacterium tuberculosis H37Rv	887052
NP_214548.1	CDS	Rv0034	NC_000962.2	36867	37262	D	Rv0034, (MTCY10H4.34), len: 131 aa. Conserved hypothetical protein, showing weak similarity to AE001980|AE001980_7 hypothetical protein from Deinococcus radiodurans (120 aa), FASTA scores: opt: 141, E(): 0.0028, (29.3% identity in 123 aa overlap).; hypothetical protein	36867..37262	Mycobacterium tuberculosis H37Rv	887046
YP_177686.1	CDS	fadD34	NC_000962.2	37259	38947	D	Rv0035, (MTCY10H4.35), len: 562 aa. Probable fadD34, fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many e.g. MBU75685_1 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 408, E(): 8.2e-20; etc. Also similar to G1171128 SAFRAMYCIN MX1 SYNTHETASE B (1770 aa), FASTA scores: opt: 445, E(): 1.3e-21, (28.1% identity in 573 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis e.g. MTCY02B10.09, FASTA score: (32.3% identity in 468 aa overlap), MTCY349_40, MTCY4D9_17, MTCY338_18, MTV045_3, MTCY409_4, MTCI237_30, MTCY24G1_8, MASC_MYCLE MASC PROTEIN, U00010_6, MTV005_21, MTCY19G5_7, MTCY9F9_39, etc.; fatty-acid-CoA ligase	37259..38947	Mycobacterium tuberculosis H37Rv	887048
NP_214550.1	CDS	Rv0036c	NC_000962.2	39056	39829	R	Rv0036c, (MTCY10H4.36c), len: 257 aa. Conserved hypothetical protein, highly similar to CAB95889.1|AL359988 conserved hypothetical protein from Streptomyces (276 aa). Also some similarity to Rv3099c|MTCY164_10 (283 aa), FASTA scores: E(): 3.3e-05, (25.9% identity in 205 aa overlap).; hypothetical protein	complement(39056..39829)	Mycobacterium tuberculosis H37Rv	887043
NP_214551.1	CDS	Rv0037c	NC_000962.2	39877	41202	R	Rv0037c, (MTCY10H4.37c), len: 441 aa. Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of macrolide, showing some similarity to Rv1258c|MTCY50_24 (419 aa), FASTA score: (25.2% identity in 408 aa overlap); and to AL049826|SCH24_20 from Streptomyces coelicolor (425 aa), FASTA scores: opt: 725, E(): 0, (36.1% identity in 418 aa overlap). Also similarity with several MACROLIDE-EFFLUX PROTEINS e.g. from S. pyogenes (405 aa), FASTA scores: E(): 1.3e-06, (22.8% identity in 416 aa overlap).; integral membrane protein	complement(39877..41202)	Mycobacterium tuberculosis H37Rv	887042
NP_214552.1	CDS	Rv0038	NC_000962.2	41304	41912	D	Rv0038, (MTCY10H4.38), len: 202 aa. Conserved hypothetical protein, equivalent to MLCB1770_16|Q50191|Y038_MYCLE hypothetical 22.0 kDa from Mycobacterium leprae (202 aa), FASTA scores: opt: 1194, E(): 0, (88.6% identity in 202 aa overlap). Also highly similar or similar to other hypothetical proteins e.g. CAB72194.1|AL138851|SCE59.07c from Streptomyces coelicolor (193 aa); AAC06288.1|AF050466 from Mycobacterium bovis (82 aa) (similarity in N-terminus); NP_224347.1|NC_000922|YqgE from Chlamydophila pneumoniae (188 aa); YQGE_ECOLI HYPOTHETICAL 20.7 kDa PROTEIN (187 aa), FASTA score: (29.5% identity in 166 aa overlap); etc.; hypothetical protein	41304..41912	Mycobacterium tuberculosis H37Rv	887045
NP_214553.1	CDS	Rv0039c	NC_000962.2	42004	42351	R	Rv0039c, (MTCY21D4.02c, MTCY10H4.39c), len: 115 aa. Possible conserved transmembrane protein, highly similar to NP_301154.1|NC_002677|Z70722|MLCB1770_18 hypothetical protein from Mycobacterium leprae (113 aa), FASTA scores: opt: 492, E(): 7.8e-27, (64.9% identity in 114 aa overlap).; transmembrane protein	complement(42004..42351)	Mycobacterium tuberculosis H37Rv	887038
NP_214554.2	CDS	mtc28	NC_000962.2	42433	43365	R	Rv0040c, (MTCY21D4.03c), len: 310 aa. mtc28, secreted proline rich 28 kDa antigen protein (has hydrophobic stretch at N-terminus) (see citation below). Highly similar to O33075|PR28_MYCLE|MT10019 Proline rich 28 kDa antigen from Mycobacterium leprae (278 aa), FASTA scores: opt: 1007, E(): 0, (65.0% identity in 257 aa overlap); and Q9CD47|LPQT_MYCLE|NP_301305.1|NC_002677 putative lipoprotein from Mycobacterium leprae (218 aa). C-terminal part very similar to lipoprotein Rv1016c from Mycobacterium tuberculosis.; secreted proline rich protein MTC28 (proline rich 28 kDa antigen)	complement(42433..43365)	Mycobacterium tuberculosis H37Rv	887037
NP_214555.1	CDS	leuS	NC_000962.2	43562	46471	D	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase	43562..46471	Mycobacterium tuberculosis H37Rv	887040
NP_214556.1	CDS	Rv0042c	NC_000962.2	46581	47207	R	Rv0042c, (MTCY21D4.05c), len: 208 aa. Possible transcriptional regulatory protein, MarR-family, highly similar except in N-terminus to CAC32228.1|AL583926 putative MarR-family regulatory protein from Mycobacterium leprae (243 aa). Also similar in part to others e.g. AB76343.1|AL158061 putative MarR-family transcriptional regulator from Streptomyces coelicolor (163 aa); NP_384406.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR PROTEIN from Sinorhizobium meliloti (164 aa); NP_531782.1|NC_003304 transcriptional regulator, MarR family from Agrobacterium tumefaciens (151 aa); etc. Also some similarity to Mycobacterium tuberculosis proteins Rv2327, Rv0880, and Rv1404.; MarR family transcriptional regulator	complement(46581..47207)	Mycobacterium tuberculosis H37Rv	887034
NP_214557.1	CDS	Rv0043c	NC_000962.2	47366	48100	R	Rv0043c, (MTCY21D4.06c), len: 244 aa. Probable transcriptional regulator, GntR family, similar to others e.g. NP_420584.1|NC_002696 transcriptional regulator GntR family from Caulobacter crescentus (221 aa); NP_294539.1|NC_001263 transcriptional regulator GntR family from Deinococcus radiodurans (267 aa); YIN1_STRAM|P32425 hypothetical transcriptional regulatory protein from Streptomyces ambofaciens (236 aa), FASTA scores: opt: 170, E(): 9.8e-05, (27.6% identity in 127 aa overlap); etc. Similar also to SC9B10_7 from Streptomyces coelicolor FASTA score: E():0.00038; and Rv0165c|MTCI28_5 from Mycobacterium tuberculosis (264 aa), FASTA score: (27.7% identity in 130 aa overlap).; GntR family transcriptional regulator	complement(47366..48100)	Mycobacterium tuberculosis H37Rv	887032
NP_214558.1	CDS	Rv0044c	NC_000962.2	48233	49027	R	Rv0044c, (MTCY21D4.07c), len: 264 aa. Possible oxidoreductase (EC 1.-.-.-), highly similar to AAD32732.1|MmcI|AF127374| F420-dependent H4MPT reductase from Streptomyces lavendulae (264 aa). Also similar to Mycobacterium tuberculosis proteins e.g. Rv1855c, Rv0953c, Rv0791c, Rv0132c, etc.; oxidoreductase	complement(48233..49027)	Mycobacterium tuberculosis H37Rv	887030
NP_214559.1	CDS	Rv0045c	NC_000962.2	49043	49939	R	Rv0045c, (MTCY21D4.08c), len 298 aa. Possible hydrolase (EC 3.-.-.-), showing similarity with others eg NP_107230.1|NC_002678 putative hydrolase from Mesorhizobium loti (278 aa); CAB56730.1|AL121600 putative hydrolase from Streptomyces coelicolor (302 aa); NP_438361.1|NC_000907 putative esterase/lipase from Haemophilus influenzae Rd (287 aa); etc. Also similar to Mycobacterium tuberculosis proteins Rv3473c, Rv1123c, Rv1938, Rv3617, Rv3670, etc.; hydrolase	complement(49043..49939)	Mycobacterium tuberculosis H37Rv	887029
NP_214560.1	CDS	ino1	NC_000962.2	50021	51124	R	Rv0046c, (MTCY21D4.09c), len: 367 aa. ino1 (alternate gene name: tbINO), myo-inositol-1-phosphate synthase (EC 5.5.1.4) (see citations below), equivalent to Q57240|Y046_MYCLE|U00015_14|G466956|B1620_F3_113 HYPOTHETICAL 40.3 KDA PROTEIN from Mycobacterium leprae (369 aa), FASTA scores: opt: 2221, E(): 0, (91.8% identity in 366 aa overlap). N-terminus similar to N-terminus of myo-inositol-1-phosphate synthases e.g. INO1_SPIPO|P42803 myo-inositol-1-phosphate synthase (510 aa), FASTA scores: opt: 144, E(): 0.021, (25.2% identity in 365 aa overlap); CAC21218.1|AJ401007 myo-inositol 1P synthase from Thermotoga sp. SG1 (335 aa); etc. Also highly similar to other hypothetical proteins e.g. AL049826|SCH24_21c hypothetical protein from Streptomyces coelicolor (360 aa), FASTA scores: opt: 1790, E(): 0, (77.8% identity in 360 aa overlap); AE000881_1 conserved protein from M. thermoautotrophicus (368 aa); etc.; tbINO; myo-inositol-1-phosphate synthase INO1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase)	complement(50021..51124)	Mycobacterium tuberculosis H37Rv	887028
NP_214561.1	CDS	Rv0047c	NC_000962.2	51185	51727	R	Rv0047c, (MTCY21D4.10c), len: 180 aa. Conserved hypothetical protein, equivalent to NP_302717.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (180 aa). Also showing strong similarity to other hypothetical proteins e.g. AL049826|SCH24_22|T36587 from Streptomyces coelicolor (225 aa), FASTA scores: opt: 583, E(): 9e-31, (51.4% identity in 177 aa overlap); etc. Some similarity to Rv1176c from Mycobacterium tuberculosis and to P94443|YFIO from Bacillus subtilis (182 aa), FASTA scores: E(): 0.00066, (24.9% identity in 177 aa overlap). Also some similarity to G1163121 MITHRAMYCIN RESISTANCE DETERMINANT, ATP-BINDING PROTEIN (219 aa), FASTA scores: opt: 143, E(): 0.0091, (29.4% identity in 180 aa overlap).; hypothetical protein	complement(51185..51727)	Mycobacterium tuberculosis H37Rv	887031
NP_214562.1	CDS	Rv0048c	NC_000962.2	51828	52697	R	Rv0048c, MTCY21D4.11c, len: 289 aa. Possible membrane protein.; hypothetical protein	complement(51828..52697)	Mycobacterium tuberculosis H37Rv	887027
NP_214563.1	CDS	Rv0049	NC_000962.2	52831	53244	D	Rv0049, (MTCY21D4.12), len: 137 aa. Conserved hypothetical protein, only equivalent to AL022118|MLCB1913_20 hypothetical protein from Mycobacterium leprae (138 aa), FASTA scores: opt: 768, E(): 0, (83.9% identity in 137 aa overlap).; hypothetical protein	52831..53244	Mycobacterium tuberculosis H37Rv	887024
YP_177687.1	CDS	ponA1	NC_000962.2	53663	55699	D	Rv0050, (MTCY21D4.13), len: 678 aa. Probable ponA1, penicillin-binding protein (class A), bienzymatic protein with transglycosylase (EC 2.4.2.-) and transpeptidase (EC 3.4.-.-) activities (see Graham & Clark-Curtiss 1999), highly similar to many e.g. NP_302715.1|NC_002677 penicillin-binding protein from Mycobacterium leprae (708 aa); AAB53123.1|L39923 penicillin binding protein from Mycobacterium leprae (686 aa), FASTA scores: (82.3% identity in 679 aa overlap); Q9F9V7|PONA|AAG13121.1|AF165523_1|AF165523 penicillin-binding protein 1 from Mycobacterium smegmatis (715 aa) (see Billman-Jacobe et al., 1999); CAB88838.1|AL353832 probable penicillin-binding protein from Streptomyces coelicolor (756 aa); etc. Also similar to ponA2|Rv3682|MTV025.030 BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B from Mycobacterium tuberculosis (810 aa). BELONGS TO THE TRANSGLYCOSYLASE FAMILY IN THE N-TERMINAL SECTION, AND TO THE TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION.; bifunctional penicillin-binding protein 1A/1B	53663..55699	Mycobacterium tuberculosis H37Rv	887065
NP_214565.1	CDS	Rv0051	NC_000962.2	55696	57378	D	Rv0051, (MTCY21D4.14), len:560 aa. Probable conserved transmembrane protein, equivalent to NP_302714.1|NC_002677 conserved membrane protein from Mycobacterium leprae (564 aa); and highly similar to C-terminus of AAF25828.1|AF187306_1|AF187306 putative transmembrane protein from Mycobacterium smegmatis (692 aa). Also highly similar to MSGDNAB_5|G886306|L222-ORF5 (418 aa), FASTA scores: opt: 2163, E(): 0, (78.4% identity in 412 aa overlap). Also similar to AL049826|SCH24_24|T36589 probable transmembrane protein from Streptomyces coelicolor (502 aa), FASTA scores: opt: 492, E(): 1.4e-23, (35.8% identity in 522 aa overlap).; transmembrane protein	55696..57378	Mycobacterium tuberculosis H37Rv	887018
NP_214566.1	CDS	Rv0052	NC_000962.2	57410	57973	D	Rv0052, (MTCY21D4.15), len: 187 aa. Conserved hypothetical protein, similar to others e.g. AL049587|SC5F2A_30S|T35272 hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 531, E(): 3.4e-29, (49.5% identity in 182 aa overlap); NP_420588.1|NC_002696 ThiJ/PfpI family protein from Caulobacter crescentus (267 aa); etc. Some similarity to Escherichia coli G1100872|thiJ (198 aa), FASTA scores: opt: 178, E(): 6.1e-06, (29.9% identity in 137 aa overlap). Also similar to Rv1930c from Mycobacterium tuberculosis (174 aa). May be a membrane protein.; hypothetical protein	57410..57973	Mycobacterium tuberculosis H37Rv	887015
NP_214567.1	CDS	rpsF	NC_000962.2	58192	58482	D	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6	58192..58482	Mycobacterium tuberculosis H37Rv	887020
NP_214568.1	CDS	ssb	NC_000962.2	58586	59080	D	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein	58586..59080	Mycobacterium tuberculosis H37Rv	887013
YP_177688.1	CDS	rpsR	NC_000962.2	59122	59376	D	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18	59122..59376	Mycobacterium tuberculosis H37Rv	887022
NP_214570.1	CDS	rplI	NC_000962.2	59409	59867	D	in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9	59409..59867	Mycobacterium tuberculosis H37Rv	887010
NP_214571.1	CDS	Rv0057	NC_000962.2	59896	60417	D	Rv0057, (MTCY21D4.20), len: 173 aa. Hypothetical unknown protein.; hypothetical protein	59896..60417	Mycobacterium tuberculosis H37Rv	887008
NP_214572.1	CDS	dnaB	NC_000962.2	60396	63020	D	unwinds double stranded DNA; these Mycobacterial enzymes appear to contain inteins; replicative DNA helicase	60396..63020	Mycobacterium tuberculosis H37Rv	887009
NP_214573.1	CDS	Rv0059	NC_000962.2	63200	63892	D	Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein.; hypothetical protein	63200..63892	Mycobacterium tuberculosis H37Rv	887006
NP_214574.1	CDS	Rv0060	NC_000962.2	63909	64967	D	Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein, showing weak similarity to NP_104623.1|NC_002678 hypothetical protein from Mesorhizobium loti (155 aa); and AP000062|AP000062_92 hypothetical protein from Aeropyrum pernix (194 aa), FASTA scores: opt: 186, E(): 4.2e-05, (30.9% identity in 165 aa overlap).; hypothetical protein	63909..64967	Mycobacterium tuberculosis H37Rv	887004
NP_214575.1	CDS	Rv0061	NC_000962.2	64991	65416	D	Rv0061, (MTV030.04), len: 141 aa (questionable ORF). Hypothetical unknown protein.; hypothetical protein	64991..65416	Mycobacterium tuberculosis H37Rv	887003
YP_177689.1	CDS	celA1	NC_000962.2	65552	66694	D	Rv0062, (MTV030.05), len: 380 aa. Possible celA1, cellulase (EC 3.2.1.4), similar to many e.g. AB65568.1|AL136058 putative secreted endoglucanase (cellulase) from Streptomyces coelicolor (332 aa); P07984|GUNA_CELFI ENDOGLUCANASE A PRECURSOR from Cellulomonas fimi (449 aa); GUN1_STRHA|P33682 endoglucanase 1 precursor (cellulase) from STREPTOMYCES HALSTEDII (321 aa), FASTA scores: opt: 702, E(): 1. 2e-27, (38.9% identity in 319 aa overlap); etc. SEEMS TO BELONG TO CELLULASE FAMILY B (FAMILY 6 OF GLYCOSYL HYDROLASES). Note that previously known as celA.; celA; endo-1,4-beta-glucanase	65552..66694	Mycobacterium tuberculosis H37Rv	887007
NP_214577.1	CDS	Rv0063	NC_000962.2	66923	68362	D	Rv0063, (MTV030.06), len: 479 aa. Possible oxidoreductase (EC 1.-.-.-), similar to many e.g. HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase from Arthrobacter oxidans (458 aa), FASTA scores: opt: 343, E(): 3.4e-13, (27.4% identity in 467 aa overlap); AAD28454.1|AF127374_9|AF127374|MitR oxidase from Streptomyces lavendulae (514 aa); AAF81732.1|AF254925|EncM putative FAD-dependent oxygenase from Streptomycesmaritimus (464 aa); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3107c, Rv1257c, etc. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site.; oxidoreductase	66923..68362	Mycobacterium tuberculosis H37Rv	886999
NP_214578.1	CDS	Rv0064	NC_000962.2	68620	71559	D	Rv0064, (MTV030.07), len: 979 aa. Probable conserved transmembrane protein, highly similar to NP_301532.1| (NC_002677) putative integral membrane protein from Mycobacterium leprae (983 aa). Also similar to other hypothetical proteins from ARCHAEOGLOBUS FULGIDUS and Synecocystis sp. e.g. P72637|D90899 HYPOTHETICAL 117.2 kDa PROTEIN from SYNECHOCYSTIS SP. (1032 aa), FASTA scores: opt: 1004, E(): 3.6e-32, (31.0 % identity in 848 aa overlap); and CAC01334.1|AL390968 putative integral membrane protein (fragment) from Streptomyces coelicolor (815 aa); etc. Also similar to Rv3193c from Mycobacterium tuberculosis (992 aa), FASTA score: (50.3% identity in 985 aa overlap). Contains probable coiled-coil domain from aa 948 to 976.; hypothetical protein	68620..71559	Mycobacterium tuberculosis H37Rv	886996
NP_214579.1	CDS	Rv0065	NC_000962.2	71821	72222	D	Rv0065, (MTV030.08), len: 133 aa. Conserved hypothetical protein, similar to several hypothetical proteins from Mycobacterium tuberculosis: Rv0960 (127 aa), Rv1720c (129 aa), and Rv0549c (137 aa).; hypothetical protein	71821..72222	Mycobacterium tuberculosis H37Rv	886993
NP_214580.1	CDS	icd2	NC_000962.2	72274	74511	R	NADP; Rv0066c, (MTV030.09c), len: 745 aa. Probable icd2, isocitrate dehydrogenase NADP-dependent (EC 1.1.1.42), equivalent to NP_302705.1|NC_002677 isocitrate dehydrogenase [NADP] from Mycobacterium leprae (746 aa). Also highly similar to many members of the monomeric-type family of IDH e.g. NP_251314.1|NC_002516 isocitrate dehydrogenase from Pseudomonas aeruginosa (741 aa); IDH_AZOVI|P16100 isocitrate dehydrogenase (nadp) from Azotobacter vinelandii (741 aa), FASTA scores: opt: 3106, E(): 0, (61.4% identity in 735 aa overlap); NP_230786.1|NC_002505 isocitrate dehydrogenase from Vibrio cholerae (741 aa); etc. BELONGS TO THE MONOMERIC-TYPE FAMILY OF IDH; isocitrate dehydrogenase	complement(72274..74511)	Mycobacterium tuberculosis H37Rv	887016
NP_214581.1	CDS	Rv0067c	NC_000962.2	74629	75198	R	Rv0067c, (MTV030.10c), len: 189 aa. Possible transcriptional regulator, highly similar except in N-terminus to T44726 probable transcription regulator from Mycobacterium leprae (189 aa), FASTA scores: opt: 829, E(): 0, (68.3% identity in 189 aa overlap). And similar to others, often many members of the tetR family, e.g. T36918 probable transcription regulator from Streptomyces coelicolor (202 aa); NP_535866.1|NC_003306 transcriptional regulator TetR family from Agrobacterium tumefaciens strain C58 (Dupont) (194 aa); UIDR_ECOLI|Q59431 uid operon repressor (gus operon repressor) from Escherichia coli (196 aa), FASTA scores: opt: 200, E(): 7.2e-06, (24.7% identity in 186 aa overlap); etc. Also similar to MTCY8D5_28 from Mycobacterium tuberculosis cosmid (229 aa), FASTA score: (32.7% identity in 168 aa overlap). Contains probable helix-turn-helix motif from aa 34 to 55 (Score 1523, +4.37 SD).; TetR family transcriptional regulator	complement(74629..75198)	Mycobacterium tuberculosis H37Rv	886991
NP_214582.1	CDS	Rv0068	NC_000962.2	75301	76212	D	Rv0068, (MTV030.11), len: 303 aa. Probable oxidoreductase (EC 1.-.-.-), equivalent to NP_301343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (304 aa). Also highly similar to many e.g. NP_485762.1|NC_003272 probable oxidoreductase from Nostoc sp. PCC 7120 (311 aa); NP_279536.1|NC_002607|YajO1 probable oxidoreductase from Halobacterium sp. NRC-1 (316 aa); OXIR_STRAT|Q03326 probable oxidoreductase from Streptomyces antibioticus (298 aa), FASTA scores: opt: 430, E(): 1.3e-16, (34.9% identity in 295 aa overlap); etc. Also highly similar to MTV037_3 and MTV022_13 from Mycobacterium tuberculosis.; short chain dehydrogenase	75301..76212	Mycobacterium tuberculosis H37Rv	886989
NP_214583.1	CDS	sdaA	NC_000962.2	76237	77622	R	Rv0069c, (MTV030.12c), len: 461 aa. Probable sdaA, L-serine dehydratase (EC 4.2.1.13), equivalent to NP_302203.1| NC_002677 L-serine dehydratase from Mycobacterium leprae (458 aa). Also highly similar to many e.g. NP_251133.1|NC_002516 L-serine dehydratase from Pseudomonas aeruginosa (458 aa); O86564|SDHL_STRCO L-SERINE DEHYDRATASE from Streptomyces coelicolor (455 aa); SDHL_ECOLI|P16095 L-serine dehydratase 1 from Escherichia coli (454 aa), FASTA scores: opt: 1381, E(): 0, (51.1% identity in 460 aa overlap); etc. BELONGS TO THE IRON-SULFUR DEPENDENT L-SERINE DEHYDRATASE FAMILY. COFACTOR: IRON-SULFUR (4FE-4S) (PROBABLE).; L-serine dehydratase SdaA	complement(76237..77622)	Mycobacterium tuberculosis H37Rv	886986
NP_214584.1	CDS	glyA	NC_000962.2	77619	78896	R	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase	complement(77619..78896)	Mycobacterium tuberculosis H37Rv	886983
NP_214585.1	CDS	Rv0071	NC_000962.2	79486	80193	D	Rv0071, (MTV030.14), len: 235 aa. Possible maturase, similar to many proteins of the group II intron maturase family e.g. P95451|U77945 MATURASE-RELATED PROTEIN from PSEUDOMONAS ALCALIGENES (297 aa), FASTA scores: opt: 395, E(): 1.7e-20, (43.5% identity in 147 aa overlap); N-terminus of AAD16434.1|AF101076 maturase-related protein from Pseudomonas putida (473 aa); N-terminus of NP_437373.1|NC_003078 putative reverse transcriptasematurase protein from Sinorhizobium meliloti (453 aa); etc. Also similar to MLCL581_1 from Mycobacterium leprae. Contains 5 VDP repeats at N-terminus, these are also found in two Streptococcus plasmid hypothetical proteins Q52246|X17092 and Q54942|X66468.; maturase	79486..80193	Mycobacterium tuberculosis H37Rv	886988
NP_214586.1	CDS	Rv0072	NC_000962.2	80624	81673	D	Rv0072, (MTV030.16), len: 349 aa. Probable glutamine-transport transmembrane protein ABC-transporter (see citation below), showing weak similarity to NP_465894.1|NC_003210 protein similar to putative ABC-transporter transmembrane subunit from Listeria monocytogenes EGD-e (367 aa); NP_471800.1|NC_003212 protein similar to putative ABC-transporter transmembrane subunit from Listeria innocua (367 aa); E1204111|AJ003195 MEMBRANE SPANNING SUBUNIT DEVC from ANABAENA VARIABILIS (385 aa), FASTA scores: opt: 155, E(): 8.1e-07, (22.0% identity in 381 aa overlap). Also highly similar to Rv2563|Y0A5_MYCTU|Q50735|MTCY9C4.05c from Mycobacterium tuberculosis (388 aa), FASTA scores: E(): 0, (76.2% identity in 349 aa overlap). Note that supposed act with near ORF Rv0073|MTV030.17 ATP-binding protein ABC-transporter.; glutamine-transport transmembrane protein ABC transporter	80624..81673	Mycobacterium tuberculosis H37Rv	886984
NP_214587.1	CDS	Rv0073	NC_000962.2	81676	82668	D	Rv0073, (MTV030.17), len: 330 aa. Probable glutamine-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (231 aa); T34822 ABC-transporter ATP binding protein from Streptomyces coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC transporter ATP-binding protein from Escherichia coli (648 aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity in 233 aa overlap); etc. Also highly similar to Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter ATP-binding protein from Mycobacterium tuberculosis (330 aa), FASTA scores: E(): 0, (83.3% identity in 330 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that supposed act with near ORF Rv0072|MTV030.16 transmembrane ABC-transporter.; glutamine-transport ATP-binding protein ABC transporter	81676..82668	Mycobacterium tuberculosis H37Rv	886977
NP_214588.1	CDS	Rv0074	NC_000962.2	82748	83983	D	Rv0074, (MTV030.18), len: 411 aa. Conserved hypothetical protein, similar to Rv2915c|MTCY338.03c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis, and showing some simlarity to various enzymes or hypothetical proteins from other organisms, eg NP_243801.1|NC_002570 aryldialkylphosphatase from Bacillus halodurans (394 aa); NP_421471.1|NC_002696 putativ Xaa-Pro dipeptidase from Caulobacter crescentus (429 aa); NP_343436.1|NC_002754 Prolidase (Xaa-Pro dipeptidase) (pepQ-like2) from Sulfolobus solfataricus (408 aa); Q50432|M91040 ORGANO PHOSPHATE ACID ANHYDRASE OPAB from MYCOBACTERIUM SP. (409 aa), FASTA scores: opt: 166, E(): 3.9e-11, (31.2% identity in 430 aa overlap); etc.; hypothetical protein	82748..83983	Mycobacterium tuberculosis H37Rv	886976
NP_214589.1	CDS	Rv0075	NC_000962.2	83996	85168	D	Rv0075, (MTV030.19), len: 390 aa. Probable aminotransferase (EC 2.6.1.-), similar to many CLASS-II PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES (MALY/PATB SUBFAMILY) e.g. NP_302217.1|NC_002677 aminotransferase from Mycobacterium leprae (402 aa); PATB_BACSU|Q08432 putative aminotransferase b from Bacillus subtilis (387 aa), FASTA scores: opt: 684, E(): 5.4e-33, (31.3% identity in 384 aa overlap); etc. Also similar to several cystathionine beta-lyase (beta C-S lyase) e.g. AAK69425.1|AF276227_1|AF276227 from Corynebacterium glutamicum (368 aa); etc. Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv2294, Rv0858c, etc.; aminotransferase	83996..85168	Mycobacterium tuberculosis H37Rv	886982
NP_214590.1	CDS	Rv0076c	NC_000962.2	85183	85572	R	Rv0076c, (MTV030.20c), len: 129 aa. Probable membrane protein, with membrane-spanning domain at C-terminus.; hypothetical protein	complement(85183..85572)	Mycobacterium tuberculosis H37Rv	886992
NP_214591.1	CDS	Rv0077c	NC_000962.2	85636	86466	R	Rv0077c, (MTV030.21c), len: 276 aa. Possible oxidoreductase (EC 1.-.-.-), weakly similar to others e.g. CAC44600.1|AL596162 putative oxidoreductase from Streptomyces coelicolor (275 aa); P33912|BPA1_STRAU NON-HAEM BROMOPEROXIDASE BPO-A1 (BROMIDE PEROXIDASE) (EC 1.11.1.-) from Streptomyces aureofaciens (275 aa); BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 from Streptomyces aureofaciens (274 aa), FASTA scores: opt: 230, E(): 1.5e-07, (26.1% identity in 249 aa overlap); etc. Also similar to MTCY05A6_35 and MTCY1A11_10 from Mycobacterium tuberculosis. And shows some similarity in part with AAL17935.1|AY054120 putative epoxide hydrolase from Mycobacterium smegmatis (203 aa).; oxidoreductase	complement(85636..86466)	Mycobacterium tuberculosis H37Rv	886969
NP_214592.1	CDS	Rv0078	NC_000962.2	86528	87133	D	Rv0078, (MTV030.22), len: 201 aa. Probable transcriptional regulator, equivalent to NP_302706.1|NC_002677 putative TetR-family transcriptional regulator from Mycobacterium leprae (236 aa), FASTA scores: opt: 755, E(): 0, (71.4% identity in 175 aa overlap). Also similar to others e.g. NP_103770.1|NC_002678 probable transcriptional regulator from Mesorhizobium loti (208 aa); NP_384275.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR PROTEIN from Sinorhizobium meliloti (197 aa); NP_250960.1|NC_002516 probable transcriptional regulator from Pseudomonas aeruginosa (196 aa); etc. Also similar to TETC_ECOLI|P28815 transposon tn10 tetc protein from Escherichia coli (197 aa), FASTA scores: opt: 181, E(): 9.7e-05, (24.8% identity in 165 aa overlap). Contains probable helix-turn-helix motif from aa 35 to 56 (Score 1348, +3.78 SD).; transcriptional regulatory protein	86528..87133	Mycobacterium tuberculosis H37Rv	886990
YP_177616.1	CDS	Rv0078A	NC_000962.2	87208	87801	R	Rv0078A, len: 197 aa. Hypothetical unknown protein.; hypothetical protein	complement(87208..87801)	Mycobacterium tuberculosis H37Rv	3205053
NP_214593.1	CDS	Rv0079	NC_000962.2	88204	89025	D	Rv0079, (MTV030.23), len: 273 aa. Hypothetical unknown protein.; hypothetical protein	88204..89025	Mycobacterium tuberculosis H37Rv	886995
NP_214594.1	CDS	Rv0080	NC_000962.2	89022	89480	D	Rv0080, (MTV030.24), len: 152 aa. Conserved hypothetical protein, similar to several hypothetical proteins from Streptomyces coelicolor e.g. SCJ12.26|AL109989|SCJ12_24 from Streptomyces coelicolor cosmid J1 (137 aa), FASTA scores: opt: 291, E(): 4e-13, (46.5% identity in 129 aa overlap); etc.; hypothetical protein	89022..89480	Mycobacterium tuberculosis H37Rv	886966
NP_214595.1	CDS	Rv0081	NC_000962.2	89575	89919	D	Rv0081, (MTV030.25), len: 114 aa. Probable transcriptional regulator, highly similar to others e.g. AL078610|SCH35_52|T36657 probable transcription regulator from Streptomyces coelicolor (117 aa), FASTA scores: opt: 404, E(): 4.8e-22, (58.2% identity in 110 aa overlap); AAG02351.1|AF210249_10|AF210249 metal-dependent regulatory protein from Streptomyces verticillus (113 aa); NP_435817.1|NC_003037 Putative transcriptional regulator from Sinorhizobium meliloti (115 aa); etc.; transcriptional regulatory protein	89575..89919	Mycobacterium tuberculosis H37Rv	887012
NP_214596.1	CDS	Rv0082	NC_000962.2	89924	90403	D	Rv0082, (MTV030.26), len: 159 aa. Probable oxidoreductase (EC 1.-.-.-), highly highly similar or similar to other various oxidoreductases e.g. NP_143304.1|NC_000961 NADH-ubiquinone oxidoreductase subunit from Pyrococcus horikoshii (173 aa); NP_126406.1|NC_000868 CO-induced hydrogenase related, subunit L from Pyrococcus abyssi (170 aa); HYCG_ECOLI|P16433 formate hydrogenlyase subunit 7 from Escherichia coli (255 aa), FASTA scores: opt: 442, E(): 8e-29, (43.2% identity in 148 aa overlap); etc.; oxidoreductase	89924..90403	Mycobacterium tuberculosis H37Rv	886968
NP_214597.1	CDS	Rv0083	NC_000962.2	90400	92322	D	Rv0083, (MTV030.27, MTCY251.01), len: 640 aa. Probable oxidoreductase (EC 1.-.-.-), showing some similarity to other various oxidoreductases e.g. AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B from Burkholderia pseudomallei (668 aa); HYFB_ ECOLI|P23482 hydrogenase-4 component b from Escherichia coli strain K12 (672 aa), FASTA scores: opt: 995, E(): 0, (32.2% identity in 571 aa overlap); AAF13041.1|AF157639_1|AF157639 putative formate hydrogenlyase integral membrane subunit from Desulfitobacterium dehalogenans (637 aa); etc.; oxidoreductase	90400..92322	Mycobacterium tuberculosis H37Rv	886965
NP_214598.1	CDS	hycD	NC_000962.2	92328	93278	D	Rv0084, (MTCY251.02), len: 316 aa. Possible hycD (alternate gene name: hevD), formate hydrogenlyase (EC 1.-.-.-), integral membrane protein, similar to others e.g. HYCD_ECOLI|P16430 formate hydrogenlyase subunit 4 from Escherichia coli (307 aa), FASTA scores: opt: 570, E(): 2.1e-26, (33.8% identity in 305 aa overlap); AAK06856.1|AF335723_2|AF335723 formate hydrogenlyase subunit 4 from Burkholderia pseudomallei (316 aa); NP_457244.1|NC_003198 formate hydrogenlyase subunit 4 from Salmonella enterica subsp. enterica serovar Typhi (307 aa); etc. Also similar to NUOH_ECOLI|P33603 NADH dehydrogenase I chain H from Escherichia coli (325 aa), FASTA scores: opt: 207, E(): 9.5e-06, (26.5% identity in 260 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY.; hevD; formate hydrogenlyase HYCD	92328..93278	Mycobacterium tuberculosis H37Rv	886959
NP_214599.1	CDS	hycP	NC_000962.2	93289	93951	D	Rv0085, (MTCY251.03), len: 220 aa. Possible hycP, hydrogenase (EC 1.-.-.-), integral membrane protein, weakly similar to P77524|HYFE_ECOLI HYDROGENASE-4 COMPONENT E from Escherichia coli (216 aa), FASTA scores: opt: 204, E():1.2e-07, (25.5% identity in 216 aa overlap).; hydrogenase HycP	93289..93951	Mycobacterium tuberculosis H37Rv	886973
NP_214600.1	CDS	hycQ	NC_000962.2	93951	95417	D	Rv0086, (MTCY251.04), len: 488 aa. Possible hycQ, hydrogenase (EC 1.-.-.-), integral membrane protein, weakly similar to P77437|HYFF_ECOLI HYDROGENASE-4 COMPONENT F from Escherichia coli (526 aa), FASTA scores: opt: 948, E(): 0, (35.9% identity in 493 aa overlap); and AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B from Burkholderia pseudomallei (668 aa). Also similar to d9087711 & NUOL_ECOLI|P33607 NADH dehydrogenase I chain L from Escherichia coli (613 aa), FASTA scores: opt: 360, E():3.2e-13, (27.9% identity in 488 aa overlap); and to NUON_ECOLI|P33608 NADH dehydrogenase I chain N from Escherichia coli (425 aa), FASTA scores: opt: 375, E(): 3.9e-14, (25.0% identity in 432 aa overlap).; hydrogenase HycQ	93951..95417	Mycobacterium tuberculosis H37Rv	886963
NP_214601.1	CDS	hycE	NC_000962.2	95414	96892	D	Rv0087, (MTCY251.05), len: 492 aa. Possible hycE (alternate gene name: hevE), formate hydrogenlyase (EC 1.-.-.-), similar to others e.g. HYCE_ECOLI|P16431 formate hydrogenlyase subunit 5 from Escherichia coli (569 aa), FASTA scores: opt: 680, E(): 1.8e-38, (31.2% identity in 449 aa overlap); NP_457243.1|NC_003198 formate hydrogenlyase subunit 5 from Salmonella enterica subsp. enterica serovar Typhi (569 aa); NP_275541.1|NC_000916 formate hydrogenlyase subunit 5 from Methanothermobacter thermautotrophicus (370 aa); etc. Also some similarity with NUOD_ECOLI|P33600 NADH dehydrogenase I chain D from Escherichia coli (407 aa), FASTA scores: opt: 245, E(): 8.9e-10, (24.5% identity in 368 aa overlap). BELONGS TO THE COMPLEX I 49 kDa SUBUNIT FAMILY.; hevE; formate hydrogenase HycE	95414..96892	Mycobacterium tuberculosis H37Rv	886956
NP_214602.1	CDS	Rv0088	NC_000962.2	96927	97601	D	Rv0088, (MTCY251.06), len: 224 aa. Hypothetical unknown protein.; hypothetical protein	96927..97601	Mycobacterium tuberculosis H37Rv	886954
NP_214603.1	CDS	Rv0089	NC_000962.2	97758	98351	D	Rv0089, (MTCY251.07), len: 197 aa. Possible methyltransferase (EC 2.1.1.-), showing some weak similarity to others e.g. NP_299749.1|NC_002488 3-demethylubiquinone-9 3-methyltransferase from Xylella fastidiosa 9a5c (246 aa); CAC44277.1| (AL596030) putative methyltransferase from Streptomyces coelicolor (285 aa); NP_111415.1|NC_002689 Predicted SAM-dependent methyltransferase from Thermoplasma volcanium (245 aa); etc. Also some similarity with many biotin biosynthesis proteins e.g. P12999|BIOC_ECOLI|B0777 BIOTIN SYNTHESIS PROTEIN from Escherichia coli (251 aa), FASTA scores: opt: 202, E(): 4.5e-07, (39.0% identity in 118 aa overlap); etc. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY.; methyltransferase/methylase	97758..98351	Mycobacterium tuberculosis H37Rv	886949
NP_214604.1	CDS	Rv0090	NC_000962.2	98480	99250	D	Rv0090, (MTCY251.08), len: 256 aa. Possible membrane protein.; hypothetical protein	98480..99250	Mycobacterium tuberculosis H37Rv	886961
NP_214605.1	CDS	mtn	NC_000962.2	99684	100451	D	Rv0091, (MTCY251.10), len: 255 aa. Probable mtn (alternate gene name: pfs), methylthioadenosine/S-Adenosylhomocysteine nucleosidase (MTA/SAH nucleosidase), including 5'-methylthioadenosine nucleosidase (EC 3.2.2.16) and S-adenosylhomocysteine nucleosidase (EC 3.2.2.9), similar to others e.g. NP_521493.1|NC_003295 PROBABLE BIFUNCTIONAL PROTEIN (MTA/SAH NUCLEOSIDASE) (P46): 5'-METHYLTHIOADENOSINE NUCLEOSIDASE AND S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE from Ralstonia solanacearum (261 aa); AAC45731.1|U55214 Pfs from Treponema pallidum (249 aa); P96122|MTN_TREPA MTA/SAH NUCLEOSIDASE from Treponema pallidum (269 aa); PFS_ECOLI|P24247 pfs protein (p46) from Escherichia coli (232 aa), FASTA scores: opt: 214, E(): 3.8e-08, (30.5% identity in 246 aa overlap); etc. BELONGS TO THE MTN FAMILY.; pfs; bifunctional 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase	99684..100451	Mycobacterium tuberculosis H37Rv	886953
NP_214606.1	CDS	ctpA	NC_000962.2	100583	102868	D	Rv0092, (MTCY251.11), len: 761 aa. Probable ctpA, cation-transporting P-type ATPase A (transmembrane protein) (EC 3.6.3.-), highly similar to others e.g. CTPA_MYCLE|P46839 cation-transporting P-type ATPase A from Mycobacterium leprae (780 aa), FASTA scores: opt: 3454, E(): 0, (74.4% identity in 741 aa overlap); CAB66270.1|AL136519 probable cation-transporting P-type ATPase from Streptomyces coelicolor (760 aa); NP_391230.1|NC_000964 protein similar to heavy metal-transporting ATPase from Bacillus subtilis (803 aa); etc. Also highly similar to MTCY251.22c from Mycobacterium tuberculosis, FASTA score: (68.3% identity in 742 aa overlap). Contains PS01047 Heavy-metal-associated domain, and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB.; cation transporter P-type ATPase A	100583..102868	Mycobacterium tuberculosis H37Rv	886946
NP_214607.1	CDS	Rv0093c	NC_000962.2	102815	103663	R	Rv0093c, (MTCY251.12c), len: 282 aa. Probable conserved membrane protein, equivalent only to CAC30943.1|AL583924 probable integral membrane protein from Mycobacterium leprae (237 aa).; hypothetical protein	complement(102815..103663)	Mycobacterium tuberculosis H37Rv	886945
NP_214608.1	CDS	Rv0094c	NC_000962.2	103710	104663	R	Rv0094c, (MTCY251.13c), len: 317 aa. Member of 13E12 repeat family, showing some similarity to U15187|MLU15187_7 from Mycobacterium leprae (94 aa), FASTA score: (49.4% identity in 79 aa overlap).; hypothetical protein	complement(103710..104663)	Mycobacterium tuberculosis H37Rv	886943
NP_214609.1	CDS	Rv0095c	NC_000962.2	104805	105215	R	Rv0095c, (MTCY251.14c), len: 136 aa. Member of 13E12 repeat, also partially similar to AF0418|AF041819_8 from Mycobacterium bovis BCG (222 aa), FASTA score: (89.6% identity in 96 aa overlap).; hypothetical protein	complement(104805..105215)	Mycobacterium tuberculosis H37Rv	886940
YP_177690.1	CDS	PPE1	NC_000962.2	105324	106715	D	Rv0096, (MTCY251.15), len: 463 aa. Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. Z46257|MLACEA_3 aceA gene for isocitrate L from Mycobacterium leprae (438 aa), FASTA scores: opt: 1207, E(): 0, (55.3% identity in 380 aa overlap). Also similar to Z97559|MTCY261_19 from Mycobacterium tuberculosis (473 aa), FASTA score: (40.2% identity in 478 aa overlap); YHS6_MYCTU|P42611 hypothetical 50.6 kDa protein (517 aa), FASTA scores: opt: 365, E(): 4.6e-12, (37.6% identity in 178 aa overlap). Also similar to MTCY274.23c from Mycobacterium tuberculosis, FASTA score: (31.1% identity in 383 overlap). Some similarity also to MTCY31.06c and MTCY48.17 and other mycobacterial PPE family proteins.; PPE family protein	105324..106715	Mycobacterium tuberculosis H37Rv	886938
NP_214611.1	CDS	Rv0097	NC_000962.2	106734	107603	D	Rv0097, (MTCY251.16), len: 289 aa. Possible oxidoreductase (EC 1.-.-.-), equivalent to NP_302343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (289 aa). Also highly similar to BAB69377.1|AB070955 putative oxidoreductase from Streptomyces avermitilis (296 aa); and weakly similar to others e.g. NP_518867.1|NC_003295 PUTATIVE ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE OXIDOREDUCTASE PROTEIN from Ralstonia solanacearum (301 aa); NP_286110.1|NC_002655 taurine dioxygenase (2-oxoglutarate-dependent) from Escherichia coli strain O157:H7 (283 aa); NP_252624.1|NC_002516 taurine dioxygenase from Pseudomonas aeruginosa (277 aa); ECAE00014310 (283 aa), FASTA scores: opt: 304, E(): 2.6e-13, (27.8% identity in 288 aa overlap); TFDA_ALCEU|P10088 2,4-dichlorophenoxyacetate monooxygenase from A. eutropha (287 aa), FASTA scores: opt: 188, E(): 3.5e-06, (26.6% identity in 188 aa overlap); etc. Contains PS00077 Cytochrome c oxidase subunit I, copper B binding region signature.; oxidoreductase	106734..107603	Mycobacterium tuberculosis H37Rv	886942
NP_214612.1	CDS	Rv0098	NC_000962.2	107600	108151	D	Rv0098, (MTCY251.17), len: 183 aa. Conserved hypothetical protein, equivalent to CAC30948.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (183 aa). Also some similarity with BAB69378.1|AB070955 hypothetical protein from Streptomyces avermitilis (172 aa).; hypothetical protein	107600..108151	Mycobacterium tuberculosis H37Rv	886935
NP_214613.1	CDS	fadD10	NC_000962.2	108156	109778	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	108156..109778	Mycobacterium tuberculosis H37Rv	886933
NP_214614.1	CDS	Rv0100	NC_000962.2	109783	110019	D	Rv0100, (MTCY251.19), len: 78 aa. Conserved hypothetical protein, equivalent only to CAC30950.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (78 aa).; hypothetical protein	109783..110019	Mycobacterium tuberculosis H37Rv	886931
NP_214615.1	CDS	nrp	NC_000962.2	110001	117539	D	Rv0101, (MTCY251.20), len: 2512 aa. Probable nrp, peptide synthetase (EC 6.-.-.-), similar to others e.g. AAD44234.1|AF143772_40|PstB peptide synthetase from Mycobacterium avium (2552 aa); 7476034|S77657 cyclic peptide synthetase from Mycobacterium leprae (1401 aa), FASTA scores: opt: 4268, E(): 0, (65.7% identity in 1091 aa overlap); part of CAB55600.1|AJ238027 peptide synthetase from Mycobacterium smegmatis (5990). Also similar to e.g. AAD56240.1|AF184977_1|AF184977 DhbF protein from Bacillus subtilis (2378 aa); SRF1_BACSU|P27206 surfactin synthetase subunit 1 (3587 aa), FASTA scores: opt: 1708, E(): 0, (30.6% identity in 1633 aa overlap): etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), 2 x PS00455 Putative AMP-binding domain signature, and PS00012 Phosphopantetheine attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. THOUGHT TO BE NOT INVOLVED IN MYCOBACTIN BIOSYNTHESIS (see citation below).; peptide synthetase	110001..117539	Mycobacterium tuberculosis H37Rv	886951
NP_214616.1	CDS	Rv0102	NC_000962.2	117714	119699	D	Rv0102, (MTCY251.21), len: 661 aa. Probable conserved integral membrane protein, highly similar to P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible membrane protein from Mycobacterium leprae (659 aa), FASTA scores: opt: 3107, E(): 0, (70.2% identity in 662 aa overlap). Also similar to others e.g. CAC01497.1|AL391017 putative integral membrane protein from Streptomyces coelicolor (316 aa); etc. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.; integral membrane protein	117714..119699	Mycobacterium tuberculosis H37Rv	886926
NP_214617.1	CDS	ctpB	NC_000962.2	119915	122173	R	Rv0103c, (MTCY251.22c), len: 752 aa. Probable ctpB, cation-transporting P-type ATPase B (transmembrane protein) (EC 3.6.3.-), equivalent to CTPB_MYCLE|P46840 cation-transporting P-type ATPase B from Mycobacterium leprae (750 aa), FASTA scores: opt: 3615, E(): 0, (76.5% identity in 752 aa overlap). Also highly similar to others e.g. CAB96031.1|AL360055 putative metal transporter ATPase from Streptomyces coelicolor (753 aa); NP_241423.1|NC_002570 copper-transporting ATPase from Bacillus halodurans (806 aa); etc. Also highly similar to Z46257|MLACEA_7 aceA gene for isocitrate L from Mycobacterium leprae (750 aa), FASTA scores: opt: 3615, E():0, (76.5% identity in 752 aa overlap). And similar to MTCY251.11 from Mycobacterium tuberculosis, FASTA score: (68.3% identity in 742 aa overlap). Contains PS01047 Heavy-metal-associated domain, PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB.; cation-transporter P-type ATPase B	complement(119915..122173)	Mycobacterium tuberculosis H37Rv	886928
NP_214618.1	CDS	Rv0104	NC_000962.2	122317	123831	D	Rv0104, (MTCY251.23), len: 504 aa. Conserved hypothetical protein, showing weak similarity with other cAMP-dependent protein kinases e.g. AAC37564.1|M65066 cAMP-dependent protein kinase RI-beta regulatory subunit from Homo sapiens (380 aa); etc.; hypothetical protein	122317..123831	Mycobacterium tuberculosis H37Rv	886923
YP_177691.1	CDS	rpmB	NC_000962.2	123980	124264	R	required for 70S ribosome assembly; 50S ribosomal protein L28	complement(123980..124264)	Mycobacterium tuberculosis H37Rv	886920
NP_214620.1	CDS	Rv0106	NC_000962.2	124374	125570	D	Rv0106, (MTCY251.25), len: 398 aa. Conserved hypothetical protein, similar to others e.g. AL049841|SCE9_33 from Streptomyces coelicolor (370 aa), FASTA scores: opt: 282, E(): 2.5e-11, (32.0% identity in 381 aa overlap); etc. Some similarity to P94400 HOMOLOGUE TO NITRILE HYDRATASE REGION from Bacillus subtilis (397 aa), FASTA scores: opt: 226, E(): 5.4e-08, (26.4% identity in 405 aa overlap). Also similar to COBW_PSEDE|P29937 FASTA score: (25.3% identity in 186 aa overlap); and P47K_PSECL|P31521 47 kDa protein (p47k) (419 aa), FASTA score: (25.9% identity in 401 aa overlap).; hypothetical protein	124374..125570	Mycobacterium tuberculosis H37Rv	886919
NP_214621.1	CDS	ctpI	NC_000962.2	125643	130541	R	Rv0107c, (MTCY251.26c, MTV031.01c), len: 1632 aa. Probable ctpI, cation-transporting ATPase I P-type (EC 3.6.3.-), highly similar to NP_302704.1|NC_002677 probable cation transport ATPase from Mycobacterium leprae (1609 aa); and similar to others e.g. CAB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); ATA1_SYNY|P37367 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 603, E(): 6.6e-29, (32.4% identity in 710 aa overlap); etc. Also similar to MTCY39.21c and MTCY22G10.22c from Mycobacterium tuberculosis, FASTA score: (34.4% identity in 796 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES).; cation-transporter ATPase I	complement(125643..130541)	Mycobacterium tuberculosis H37Rv	886915
NP_214622.1	CDS	Rv0108c	NC_000962.2	130895	131104	R	Rv0108c, (MTV031.02c), len: 69 aa. Hypothetical unknown protein. TBparse score is 0.890.; hypothetical protein	complement(130895..131104)	Mycobacterium tuberculosis H37Rv	886918
YP_177692.1	CDS	PE_PGRS1	NC_000962.2	131382	132872	D	Rv0109, (MTV031.03c), len: 496 aa. Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to many e.g. Q50615|Y0DP_MYCTU HYPOTHETICAL GLYCINE-RICH 40.8 kDa PROTEIN from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1772, E(): 0, (57.3% identity in 513 aa overlap); etc. TBparse score is 0.884.; PE-PGRS family protein	131382..132872	Mycobacterium tuberculosis H37Rv	886912
NP_214624.1	CDS	Rv0110	NC_000962.2	133020	133769	D	Rv0110, (MTV031.04), len 249 aa. Probable conserved integral membrane protein, similar to many e.g. AL079308|SCH69_25 from Streptomyces coelicolor (297 aa), FASTA scores: opt: 552, E(): 6.1e-29, (45.4% identity in 251 aa overlap); P54493|YQGP_BACSU HYPOTHETICAL 56.4 KD PROTEIN from Bacillus subtilis (507 aa), FASTA scores: opt: 320, E(): 4e-15, (32.4% identity in 210 aa overlap); etc. TBparse score is 0.915.; integral membrane protein	133020..133769	Mycobacterium tuberculosis H37Rv	886917
NP_214625.1	CDS	Rv0111	NC_000962.2	133950	136007	D	Rv0111, (MTV031.05), len: 685 aa. Possible transmembrane acyltransferase (EC 2.3.1.-), equivalent to AA22904.1|AL035300 putative acyltransferase from Mycobacterium leprae (696 aa). Also similar to others e.g. C69975 acyltransferase homolog yrhL from Bacillus subtilis (634 aa), FASTA scores: opt: 520, E(): 4e-22, (36.4% identity in 382 aa overlap). Very similar to Mycobacterium tuberculosis proteins Rv0228, Rv1254, Rv1565c, etc.; transmembrane acyltransferase	133950..136007	Mycobacterium tuberculosis H37Rv	886909
NP_214626.1	CDS	gca	NC_000962.2	136289	137245	D	Rv0112, (MTV031.06), len: 318 aa. Possible gca, GDP-mannose 4,6-dehydratase (EC 4.2.1.47), similar to others e g. U18320|PAU18320_1 GDP-D-mann from Pseudomonas aeruginosa (323 aa), FASTA scores: opt: 415, E(): 4.4e-21, (27.0% identity in 318 aa overlap). Similar to Rv3634c, Rv3784, etc from Mycobacterium tuberculosis. Contains PS00061 Short-chain dehydrogenases/reductases family signature. SEEMS TO BELONG TO THE GDP-MANNOSE 4,6-DEHYDRATASE FAMILY. COFACTOR: NAD(+).; GDP-mannose 4,6-dehydratase	136289..137245	Mycobacterium tuberculosis H37Rv	886907
NP_214627.1	CDS	gmhA	NC_000962.2	137319	137909	D	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase	137319..137909	Mycobacterium tuberculosis H37Rv	886905
NP_214628.1	CDS	gmhB	NC_000962.2	137941	138513	D	Rv0114, (MTV031.08), len: 190 aa. Possible gmhB, D-alpha,beta-D-heptose-1,7-biphosphate phosphatase (EC 2.-.-.-) (see citation below), similar to several hypothetical proteins and phosphatases e.g. HIS7_ECOLI|P06987 imidazoleglycerol-phosphate dehydratase (355 aa), FASTA scores: opt: 250, E(): 3.6e-11, (34.0 % identity in 141 aa overlap).; D-alpha,beta-D-heptose-1,7-biphosphate phosphatase	137941..138513	Mycobacterium tuberculosis H37Rv	886903
NP_214629.1	CDS	hddA	NC_000962.2	138513	139673	D	Rv0115, (MTV031.09), len: 386 aa. Possible hddA, D-alpha-D-heptose-7-phosphate kinase (EC 2.-.-.-) (see citation below), similar to several hypothetical proteins and sugar kinases e.g. AAK27850.1|AF324836_3 D-glycero-D-manno-heptose 7-phosphate kinase from Aneurinibacillus thermoaerophilus (341 aa); AAK80995.1|AE007802_11 Sugar kinase from Clostridium acetobutylicum (364 aa). TBparse score is 0.951.; D-alpha-D-heptose-7-phosphate kinase	138513..139673	Mycobacterium tuberculosis H37Rv	886902
NP_214630.1	CDS	Rv0116c	NC_000962.2	140267	141022	R	Rv0116c, (MTV031.10c), len: 251 aa. Possible conserved membrane protein, showing similarity to several hypothetical mycobacterial proteins e.g. Rv1433 from Mycobacterium tuberculosis (271 aa); and Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 aa); to the C-terminal regions of others like Rv0192 from Mycobacterium tuberculosis (366 aa), FASTA scores: opt: 451, E(): 1.7e-21, (46.7% identity in 270 aa overlap); and Rv0192|Z97050|MTCI28_32 from Mycobacterium tuberculosis cosmid (366 aa), FASTA scores: opt: 699, E(): 0, (45.7% identity in 221 aa overlap). TBparse score is 0.932.; hypothetical protein	complement(140267..141022)	Mycobacterium tuberculosis H37Rv	886900
NP_214631.1	CDS	oxyS	NC_000962.2	141200	142144	D	Rv0117, (MTV031.11), len: 314 aa. OxyS, oxidative stress response protein regulatory protein, LysR family (see citation below). Similar to many transcription regulators and OxyR, the oxidative stress response protein of many bacteria. Contains LysR family signature at N-terminus. Also contains helix-turn-helix motif at aa 16-37 (Score 1543, +4.44 SD). BELONGS TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS. OXYR IS REQUIRED FOR THE INDUCTION OF A REGULON OF HYDROGEN PEROXIDE INDUCIBLE GENES SUCH AS CATALASE, GLUTATHIONE-REDUCTASE, ETC.; oxidative stress response regulatory protein OXYS	141200..142144	Mycobacterium tuberculosis H37Rv	886914
NP_214632.1	CDS	oxcA	NC_000962.2	142128	143876	R	catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase	complement(142128..143876)	Mycobacterium tuberculosis H37Rv	886898
NP_214633.1	CDS	fadD7	NC_000962.2	144049	145626	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	144049..145626	Mycobacterium tuberculosis H37Rv	886896
NP_214634.1	CDS	fusA2	NC_000962.2	145627	147771	R	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G	complement(145627..147771)	Mycobacterium tuberculosis H37Rv	886894
NP_214635.1	CDS	Rv0121c	NC_000962.2	147908	148342	R	Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved hypothetical protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155, Rv1875, Rv2074, etc.; hypothetical protein	complement(147908..148342)	Mycobacterium tuberculosis H37Rv	886892
NP_214636.1	CDS	Rv0122	NC_000962.2	148491	148859	D	Rv0122, (MTCI418B.04), len: 133 aa. Hypothetical unknown protein.; hypothetical protein	148491..148859	Mycobacterium tuberculosis H37Rv	886888
NP_214637.1	CDS	Rv0123	NC_000962.2	148856	149224	D	Rv0123, (MTCI418B.05), len: 133 aa. Hypothetical unknown protein.; hypothetical protein	148856..149224	Mycobacterium tuberculosis H37Rv	886887
YP_177693.1	CDS	PE_PGRS2	NC_000962.2	149533	150996	D	Rv0124, (MTCI418B.06), len: 487 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to many e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1730, E(): 0, (60.7% identity in 504 aa overlap).; PE-PGRS family protein	149533..150996	Mycobacterium tuberculosis H37Rv	886883
NP_214639.1	CDS	pepA	NC_000962.2	151148	152215	D	Rv0125, (MTCI418B.07, MTB32A), len: 355 aa. Probable pepA (alternate gene name: mtb32a), serine protease (EC 3.4.21.-) (see Skeiky et al., 1999), highly similar to other proteases e.g. HHOB_ECOLI|P31137 protease hhob precursor (355 aa), FASTA scores: opt: 400, E(): 3.8e-14, (32.4% identity in 346 aa overlap). Also similar to Q50320 34 kDa PROTEIN PRECURSOR from Mycobacterium tuberculosis (361 aa), FASTA scores: opt: 1689, E(): 0, (70.7% identity in 362 aa overlap). Contains PS00135 Serine proteases, trypsin family, serine active site. Has a putative signal sequence at the N-terminus. BELONGS TO THE SERINE PROTEASE FAMILY.; mtb32a; serine protease PepA	151148..152215	Mycobacterium tuberculosis H37Rv	886924
NP_214640.1	CDS	treS	NC_000962.2	152324	154129	D	Rv0126, (MTCI418B.08), len: 601 aa. treS, trehalose synthase (EC 5.4.99.-) (see citation below), highly similar to others e.g. CAA04601.2|AJ001205 putative trehalose synthase from Streptomyces coelicolor (566 aa); S71450|1536814|BAA11303.1|D78198 trehalose synthase maltose-specific from Pimelobacter sp. strain R48 (573 aa). Also similar to MAL1_DROME|P07191 possible maltase precursor (508 aa), FASTA scores: opt: 807, E(): 0, (33.7% identity in 504 aa overlap); and similar to proteins associated with amino-acid transport e.g. Q64319 rat protein which stimulates transport of cystine and dibasic and neutral amino acids (683 aa), FASTA scores: opt: 839, E(): 0, (32.0% identity in 531 aa overlap). Also similar to several other Mycobacterium tuberculosis proteins e.g. Rv2471 FASTA score: (31.7% identity in 164 aa overlap).; trehalose synthase TRES	152324..154129	Mycobacterium tuberculosis H37Rv	886881
NP_214641.1	CDS	Rv0127	NC_000962.2	154232	155599	D	Rv0127, (MTCI418B.09, MTCI5.01), len: 455 aa. Conserved hypothetical protein, highly similar to various proteins e.g. AJ0012|SCJ001205_4 hypothetical protein from Streptomyces coelicolor A3(2) (464 aa), FASTA scores: opt: 412, E(): 1.1e-19, (40.6% identity in 485 aa overlap); AJ0012|SCJ001206_5 hypothetical protein from Streptomyces coelicolor A3(2) (453 aa), FASTA scores: opt: 403, E(): 4.3 e-19, (36.5% identity in 455 aa overlap).; hypothetical protein	154232..155599	Mycobacterium tuberculosis H37Rv	886880
NP_214642.1	CDS	Rv0128	NC_000962.2	155667	156446	D	Rv0128, (MTCI5.02), len: 259 aa. Probable conserved transmembrane protein, with some similarity to Rv3064c and other bacterial proteins e.g. AAK85977.1|AE007957|AGR_C_254p from Agrobacterium tumefaciens (206 aa).; transmembrane protein	155667..156446	Mycobacterium tuberculosis H37Rv	886878
YP_177694.1	CDS	fbpC	NC_000962.2	156578	157600	R	Rv0129c, (MT0137, MTCI5.03c), len: 340 aa. fbpC (alternate gene names: mpt45, 85C, fbpC2), secreted antigen 85c (fibronectin-binding protein C) (mycolyl transferase 85C) (EC 2.3.1.-) (see citations below), also highly similar to other Mycobacterial antigen precursors e.g. A85C_MYCLE|Q05862 antigen 85-c precursor (85c) from Mycobacterium leprae (333 aa), FASTA scores: opt: 1937, E(): 0, (81.4% identity in 333 aa overlap); etc.; mpt45; 85C; fbpC2; secreted antigen 85-C FBPC (85C) (antigen 85 complex C) (AG58C) (Mycolyl transferase 85C) (fibronectin-binding protein C)	complement(156578..157600)	Mycobacterium tuberculosis H37Rv	886885
NP_214644.1	CDS	Rv0130	NC_000962.2	157847	158302	D	Rv0130, (MTCI5.04), len: 151 aa. Conserved hypothetical protein, most similar to AL096811|SCI30A_19 from Streptomyces coelicolor (153 aa), FASTA scores: opt: 639, E(): 0, (60.8% identity in 148 aa overlap). Also similar to NODN_RHILV|P08634 nodulation protein from Rhizobium leguminosarum bv. viciae plasmid pRL1JI (161 aa), FASTA scores: opt: 406, E(): 1e-21, (43.9% identity in 148 aa overlap; and to O30041 MONOAMINE OXIDASE REGULATORY PROTEIN (146 aa), FASTA scores: opt: 219, E(): 1.1e-08, (30.8% identity in 133 aa overlap).; hypothetical protein	157847..158302	Mycobacterium tuberculosis H37Rv	886876
NP_214645.1	CDS	fadE1	NC_000962.2	158315	159658	R	Rv0131c, (MTCI5.05c), len: 447 aa. Probable fadE1, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain specific precursor (412 aa), FASTA scores: opt: 522, E(): 1.4e-23, (30.1% identity in 425 aa overlap). Also highly similar to MTCI5_28 from Mycobacterium tuberculosis.; acyl-CoA dehydrogenase FADE1	complement(158315..159658)	Mycobacterium tuberculosis H37Rv	886874
NP_214646.1	CDS	fgd2	NC_000962.2	159700	160782	R	Rv0132c, (MTCI5.06c), len: 360 aa. Putative fgd2, F420-dependent glucose-6-phosphate dehydrogenase (EC 1.-.-.-), highly similar to many from Mycobacteria e.g. AAD38167|g5031431 from Mycobacterium chelonae. Also similar to MJ1534|Q58929 N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN REDUCTASE from METHANOCOCCUS JANNASCHII (342 aa), FASTA scores: opt: 285, E(): 7.9e-11, (28.4% identity in 292 aa overlap). And also similar to Rv0953c, Rv0791c, etc from Mycobacterium tuberculosis. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; putative f420-dependent glucose-6-phosphate dehydrogenase Fgd2	complement(159700..160782)	Mycobacterium tuberculosis H37Rv	886877
NP_214647.1	CDS	Rv0133	NC_000962.2	160869	161474	D	Rv0133, (MTCI5.07), len: 201 aa. Probable acetyltransferase (EC 2.3.1.-), highly similar to others e.g. PUAC_STRLP|P13249 puromycyn N-acetyltransferase (199 aa), FASTA scores: opt: 341, E(): 1.8e-16, (33.3% identity in 201 aa overlap).; acetyltransferase	160869..161474	Mycobacterium tuberculosis H37Rv	886873
NP_214648.1	CDS	ephF	NC_000962.2	161771	162673	D	Rv0134, (MTCI5.08), len: 300 aa. Possible ephE, epoxide hydrolase (EC 3.3.2.3) (see citation below), similar to others e.g. Q39856 epoxide hydrolase (341 aa), FASTA scores: opt: 369, E(): 4.6e-17, (27.2% identity in 335 aa overlap); ETC. Also similar to MTCY09F9.26c from Mycobacterium tuberculosis (29.5% identity in 346 aa overlap).; epoxide hydrolase EphF	161771..162673	Mycobacterium tuberculosis H37Rv	886871
NP_214649.1	CDS	Rv0135c	NC_000962.2	162644	163249	R	Rv0135c, (MTCI5.09c), len: 201 aa. Possible transcriptional regulator, weakly similar to others e.g. P32398|YHGD_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Bacillus subtilis (191 aa), FASTA scores: opt: 145, E(): 0.0012, (21.0% identity in 162 aa overlap).; transcriptional regulatory protein	complement(162644..163249)	Mycobacterium tuberculosis H37Rv	886869
NP_214650.1	CDS	cyp138	NC_000962.2	163366	164691	D	Rv0136, (MT0144, MTCI5.10), len: 441 aa. Probable cyp138, cytochrome P450 138 (EC 1.14.-.-), similar to others e.g. SLR0574|Q59990 from SYNECHOCYSTIS SP. (444 aa), FASTA scores: opt: 315, E(): 1e-13, (25.7% identity in 416 aa overlap); etc. Also similar to MTV039_6 from Mycobacterium tuberculosis (472 aa), FASTA score: (38.2% identity in 442 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); and PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.; cytochrome P450 138	163366..164691	Mycobacterium tuberculosis H37Rv	886868
NP_214651.1	CDS	msrA	NC_000962.2	164712	165260	R	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A	complement(164712..165260)	Mycobacterium tuberculosis H37Rv	886865
NP_214652.1	CDS	Rv0138	NC_000962.2	165323	165826	D	Rv0138, (MTCI5.12), len: 167 aa. Conserved hypothetical protein, showing weak similarity to Q10827|YT10_MYCTU HYPOTHETICAL 17.0 KDA PROTEIN from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 131, E(): 0.047, (31.15% identity in 106 aa overlap).; hypothetical protein	165323..165826	Mycobacterium tuberculosis H37Rv	886863
NP_214653.1	CDS	Rv0139	NC_000962.2	165827	166849	D	Rv0139, (MTCI5.13), len: 340 aa. Possible oxidoreductase (EC 1.-.-.-), similar to others e.g. O34285|HPNA HPNA PROTEIN from Zymomonas mobilis (337 aa), FASTA scores: opt: 507, E (): 5.8e-27, (31.1% identity in 328 aa overlap); TRE_STRGR|P29782 dtdp-glucose 4,6-dehydratase (328 aa), FASTA scores: opt: 254, E(): 2.6e-10, (29.0% identity in 307 aa overlap).; oxidoreductase	165827..166849	Mycobacterium tuberculosis H37Rv	886860
NP_214654.1	CDS	Rv0140	NC_000962.2	166910	167290	D	Rv0140, (MTCI5.14), len: 126 aa. Conserved hypothetical protein, similar to others e.g. P74567|D90916_48 HYPOTHETICAL 20.8 KDP PROTEIN from Synechocystis sp. (180 aa), FASTA scores: opt: 229, E(): 4.7e-10, (36.1% identity in 108 aa overlap). Also similar to Rv1056 and Rv1670 from Mycobacterium tuberculosis.; hypothetical protein	166910..167290	Mycobacterium tuberculosis H37Rv	886859
NP_214655.1	CDS	Rv0141c	NC_000962.2	167271	167681	R	Rv0141c, (MTCI5.15c), len: 136 aa. Hypothetical unknown protein.; hypothetical protein	complement(167271..167681)	Mycobacterium tuberculosis H37Rv	886872
NP_214656.1	CDS	Rv0142	NC_000962.2	167711	168637	D	Rv0142, (MTCI5.16), len: 208 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa).; hypothetical protein	167711..168637	Mycobacterium tuberculosis H37Rv	886858
NP_214657.1	CDS	Rv0143c	NC_000962.2	168704	170182	R	Rv0143c, (MTCI5.17c), len: 492 aa. Probable conserved transmembrane protein, CIC family possibly involved in transport of chloride, similar to others and hypothetical proteins e.g. O28857 PUTATIVE CHLORIDE CHANNEL from Archaeoglobus fulgidus (589 aa), FASTA scores: opt: 966, E(): 0, (37.7% identity in 453 aa overlap); YADQ_ECOLI|P37019 hypothetical 46.0 kDa protein (436 aa), FASTA scores: opt: 452, E(): 2.4e-20, (28.0% identity in 460 aa overlap).; transmembrane protein	complement(168704..170182)	Mycobacterium tuberculosis H37Rv	886856
NP_214658.1	CDS	Rv0144	NC_000962.2	170284	171126	D	Rv0144, (MTCI5.18), len: 280 aa. Probable transcriptional regulator, possibly tetR family. Has region similar to others e.g. Q59431|UIDR_ECOLI|GUSR|B1618|Z2623|ECS2326 UID OPERON REPRESSOR (GUS OPERON) from Escherichia coli strains K12 and O157:H7 (196 aa), FASTA scores: opt: 214, E(): 1.1e-06, (26.0% identity in 196 aa overlap). Contains probable helix-turn helix motif from aa 109-130 (Score 1463, +4.17 SD). COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.; TetR family transcriptional regulator	170284..171126	Mycobacterium tuberculosis H37Rv	886854
NP_214659.1	CDS	Rv0145	NC_000962.2	171215	172168	D	Rv0145, (MTCI5.19), len: 317 aa. Conserved hypothetical protein, highly similar to many e.g. CAC32172.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (310 aa); and several Mycobacterium tuberculosis proteins e.g. Rv0726c, Rv0731c, etc.; hypothetical protein	171215..172168	Mycobacterium tuberculosis H37Rv	886851
NP_214660.1	CDS	Rv0146	NC_000962.2	172211	173143	D	Rv0146, (MTCI5.20), len: 310 aa. Conserved hypothetical protein, highly similar to others e.g. AC30975.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (304 aa); and several Mycobacterium tuberculosis proteins e.g. Rv0726c, Rv0731c, etc.; hypothetical protein	172211..173143	Mycobacterium tuberculosis H37Rv	886849
NP_214661.1	CDS	Rv0147	NC_000962.2	173238	174758	D	Rv0147, (MTCI5.21), len: 506 aa. Probable aldehyde dehydrogenase (NAD+) dependent (EC 1.2.1.-), similar to others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase (dimeric NADP-preferring) (452 aa), FASTA scores: opt: 1291, E(): 0, (43.9% identity in 453 aa overlap). Also similar to several Mycobacterium tuberculosis aledehyde dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687 aldehyde dehydrogenases glutamic acid active site, and PS00070 aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.; aldehyde dehydrogenase	173238..174758	Mycobacterium tuberculosis H37Rv	886847
NP_214662.1	CDS	Rv0148	NC_000962.2	174833	175693	D	Rv0148, (MTCI5.22), len: 286 aa. Probable short-chain dehydrogenase (EC 1.-.-.-), similar to others, in particular Estradiol 17 beta-dehydrogenases (EC 1.1.1.62), e.g. DHB4_MOUSE|P51660 estradiol 17 beta-dehydrogenase 4 (735 aa), FASTA scores: opt: 952, E(): 0, (52.5% identity in 276 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short-chain type dehydrogenase/reductase	174833..175693	Mycobacterium tuberculosis H37Rv	886845
NP_214663.1	CDS	Rv0149	NC_000962.2	175700	176668	D	Rv0149, (MTCI5.23), len: 322 aa. Possible quinone oxidoreductase (EC 1.6.5.-), similar to others oxidoreductases e.g. Q08257 quinone oxidoreductase (EC 1.6.5.5) (329 aa), FASTA scores: opt: 397, E(): 3.2e-18, (28.4% identity in 328 aa overlap); SCHCOADH_4 from Streptomyces coelicolor. Also similar to many proteins from Mycobacterium tuberculosis. Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature. BELONG TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY.; quinone oxidoreductase	175700..176668	Mycobacterium tuberculosis H37Rv	886843
NP_214664.1	CDS	Rv0150c	NC_000962.2	176665	176952	R	Rv0150c, (MTCI5.24c), len: 95 aa. Conserved hypothetical protein, showing some similarity with C-terminus of O53949|Rv1800|MTV049.22 PPE-FAMILY PROTEIN from Mycobacterium tuberculosis (655 aa), FASTA score: (36.5% identity in 104 aa overlap).; hypothetical protein	complement(176665..176952)	Mycobacterium tuberculosis H37Rv	886840
YP_177695.1	CDS	PE1	NC_000962.2	177543	179309	R	Rv0151c, (MTCI5.25c), len: 588 aa. Member of the Mycobacterium tuberculosis PE family (see citation below), with N-terminal region similar to others e.g. MTV032_2 PE_PGRS family from Mycobacterium tuberculosis (468 aa), FASTA scores: opt: 1125, E(): 0, (46.3% identity in 456 aa overlap); MTCY493_24 from Mycobacterium tuberculosis FASTA score: (42.5% identity in 558 aa overlap). Also similar to upstream ORF MTCI5.26c FASTA score: (54.7% identity in 464 aa overlap). Also shows similarity to C-terminal part of some PPE family proteins e.g. MTV049_21 from Mycobacterium tuberculosis FASTA score: (41.5% identity in 591 aa overlap).; PE family protein	complement(177543..179309)	Mycobacterium tuberculosis H37Rv	886857
YP_177696.1	CDS	PE2	NC_000962.2	179319	180896	R	Rv0152c, (MTCI5.26c), len: 525 aa. Member of the Mycobacterium tuberculosis PE family (see citation below), similar to ORF downstream Z92770|MTCI5_25 (588 aa), FASTA scores: opt: 1492, E(): 0, (54.7% identity in 464 aa overlap); and to many other PE family type members.; PE family protein	complement(179319..180896)	Mycobacterium tuberculosis H37Rv	886838
NP_214667.1	CDS	ptbB	NC_000962.2	181155	181985	R	Rv0153c, (MTCI5.27c), len: 276 aa. ptbB (alternate gene name: MPtpB), protein-tyrosine-phosphatase (see citation below) (EC 3.1.3.48), showing some similarity to several protein-tyrosine phosphatases, polyketide synthase and aminotransferase e.g. Q05918|IPHP_NOSCO|IPH PROTEIN-TYROSINE-PHOSPHATASE PRECURSOR from Nostoc commune (EC 3.1.3.48) (294 aa), FASTA scores: opt: 150, E(): 0.0096, (26.8% identity in 269 aa overlap); etc. Supposed a secreted protein.; MPtpB; phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase)	complement(181155..181985)	Mycobacterium tuberculosis H37Rv	886842
NP_214668.1	CDS	fadE2	NC_000962.2	181987	183198	R	Rv0154c, (MTCI5.28c), len: 403 aa. Probable fadE2, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. C-terminal region of O01590 ACYL-CoA DEHYDROGENASE (974 aa), FASTA scores: opt: 1150, E(): 0, (50.0% identity in 402 aa overlap); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain) (383 aa), FASTA score: (35.0% identity in 306 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE2	complement(181987..183198)	Mycobacterium tuberculosis H37Rv	886836
NP_214669.1	CDS	pntAa	NC_000962.2	183622	184722	D	Rv0155, (MTCI5.29), len: 366 aa. Probable pntAa, first part of NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2), similar to N-terminus of others e.g. PNTA_ECOLI|P07001|P76888|B1603 NAD (P) transhydrogenase subunit alpha from Escherichia coli strain K12 (510 aa), FASTA scores: opt: 921, E(): 0, (42.1% identity in 361 aa overlap); PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA (EC 1.6.1.1).; pntAA; NAD(P) transhydrogenase subunit alpha	183622..184722	Mycobacterium tuberculosis H37Rv	886832
NP_214670.1	CDS	pntAb	NC_000962.2	184723	185055	D	Rv0156, (MTCI5.30), len: 110 aa. Probable pntAb, second part of NAD(P) transhydrogenase subunit alpha, integral membrane protein, similar to C-terminus of others e.g. Q59764 NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAB (139 aa), FASTA scores: opt: 247, E(): 1.9e-11, (45.5% identity in 88 aa overlap).; pntAB; NAD(P) transhydrogenase subunit alpha	184723..185055	Mycobacterium tuberculosis H37Rv	886890
NP_214671.1	CDS	pntB	NC_000962.2	185052	186479	D	Rv0157, (MTCI5.31), len: 475 aa. Probable pntB, pyridine nucleotide transhydrogenase (nicotinamide nucleotide transhydrogenase) subunit beta (EC 1.6.1.1), integral membrane protein, similar to others e.g. Q59763 PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT BETA from HODOSPIRILLUM RUBRUM (464 aa), FASTA scores: opt: 1344, E(): 0, (46.4% identity in 472 aa overlap); P07002|PNTB_ECOLI|P76890|PNTB|B1602|Z2597|ECS2308 NAD(P) TRANSHYDROGENASE SUBUNIT BETA from Escherichia coli strains K12 and O157:H7 (462 aa).; NAD(P) transhydrogenase subunit beta	185052..186479	Mycobacterium tuberculosis H37Rv	886830
NP_214672.1	CDS	Rv0158	NC_000962.2	186785	187429	D	Rv0158, (MTV032.01), len: 214 aa. Probable transcriptional regulator, possibly TetR family, showing weak similarity to various transcriptional activators and repressors e.g. P32398|YIXD_BACSU|YHGD HYPOTHETICAL TRANSCRIPTIONAL REGULATORY PROTEIN from Bacillus subtilis (191 aa), FASTA scores: opt:172, E(): 2.4e-05, (23.0% identity in 191 aa overlap). Contains helix-turn-helix motif at aa 32-53 (Score 1296, +3.60 SD). COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.897.; TetR family transcriptional regulator	186785..187429	Mycobacterium tuberculosis H37Rv	886828
YP_177697.1	CDS	PE3	NC_000962.2	187433	188839	R	Rv0159c, (MTV032.02c), len: 468 aa. Member of the Mycobacterium tuberculosis PE family (see citation below), similar to many other PE proteins e.g. O06828 from Mycobacterium tuberculosis (528 aa), FASTA scores: opt: 1163, E(): 0, (45.8% identity in 467 aa overlap). Also highly similar to upstream MTV032_3, and to MTCI5_25, MTCI5_26, MTV049_ 21, MTCY1A10_26, etc.; PE family protein	complement(187433..188839)	Mycobacterium tuberculosis H37Rv	886826
YP_177698.1	CDS	PE4	NC_000962.2	188931	190439	R	Rv0160c, (MTV032.03c), len: 502 aa. Member of the Mycobacterium tuberculosis PE family (see citation below), similar to many other PE proteins e.g. Z92770|MTCI5_26c from Mycobacterium tuberculosis (525 aa), FASTA scores: opt: 816, E(): 0, (41.4% identity in 367 aa overlap); C-terminal region of O06801|RV1768|MTCY28.34 from Mycobacterium tuberculosis (618 aa), FASTA scores: opt: 417, E(): 6.7e-18, (53.5% identity in 142 aa overlap). Also highly similar to downstream ORF MTV032_2.; PE family protein	complement(188931..190439)	Mycobacterium tuberculosis H37Rv	886825
NP_214675.1	CDS	Rv0161	NC_000962.2	190607	191956	D	Rv0161, (MTCI28.01, MTV032.04), len 449 aa. Possible oxidoreductase (EC 1.-.-.-), similar to hypothetical proteins and various oxidoreductases e.g. AIP2_YEAST|P46681 actin interacting protein 2 (530 aa), FASTA scores: opt: 356, E (): 0, (33.3% identity in 357 aa overlap); DLD1_YEAST|P32891 d-lactate dehydrogenase (cytochrome) (587 aa), FASTA scores: opt: 311, E(): 2.5e-20, (27.9% identity in 366 aa overlap). Also similar to other Mycobacteria proteins e.g. MTCY339.30c from Mycobacterium tuberculosis FASTA score: (29.4% identity in 357 aa overlap); MLCL622.30c from Mycobacterium tuberculosis (449 aa).; oxidoreductase	190607..191956	Mycobacterium tuberculosis H37Rv	886835
YP_177699.1	CDS	adhE1	NC_000962.2	191984	193135	R	Rv0162c, (MTCI28.02c), len: 383 aa. Probable adhE1, zinc-type alcohol dehydrogenase (EC 1.1.1.1), similar to others e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha chain (374 aa), FASTA scores: opt: 619, E(): 0, (34.7% identity in 363 aa overlap). Also similar to other alcohol dehydrogenases from Mycobacterium tuberculosis e.g. MTCY369.06c FASTA score: (34.0% identity in 365 aa overlap), MTV022_9 FASTA score: (35.0% identity in 371 aa overlap). Contains PS00059 Zinc-contain ingalcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, CLASS-I SUBFAMILY. COFACTOR: ZINC.; zinc-type alcohol dehydrogenase E subunit	complement(191984..193135)	Mycobacterium tuberculosis H37Rv	886824
NP_214677.1	CDS	Rv0163	NC_000962.2	193117	193572	D	Rv0163, (MTCI28.03), len: 151 aa. Conserved hypothetical protein, similar to others e.g. Q44017 HYPOTHETICAL 16.6 KDA PROTEIN IN GBD 5'REGION (ORF6)from Alcaligenes eutrophus (145 aa), FASTA scores: opt: 155, E(): 0.0002, (26.6% identity in 139 aa overlap). Also weak similary with MTV008.31c|Rv2475c|B70867 from Mycobacterium tuberculosis (138 aa).; hypothetical protein	193117..193572	Mycobacterium tuberculosis H37Rv	886821
YP_177617.1	CDS	TB18.5	NC_000962.2	193626	194111	D	Rv0164, (MTCI28.04), len: 161 aa. TB18.5, conserved hypothetical protein, equivalent to CAB08818.1|Z95398 HYPOTHETICAL PROTEIN from Mycobacterium leprae (156 aa) FASTA scores: opt: 762, E(): 0, (76.3% identity in 152 aa overlap). Some similarity to Rv2185c, Rv0854, Rv0857 from Mycobacterium tuberculosis. Alternative start codon has been suggested. 3' part corrected since first submission (-24 aa).; hypothetical protein	193626..194111	Mycobacterium tuberculosis H37Rv	886267
YP_177700.1	CDS	Rv0165c	NC_000962.2	194144	194938	R	Rv0165c, (MTCI28.05c), len: 264 aa. Possible transcriptional regulator, GntR family, showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI GLUCONATE OPERON TRANSCRIPTIONAL REPRESSOR from Bacillus licheniformis (243 aa); GNTR_BACSU GLUCONATE OPERON REPRESSOR from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL REGULATORS.; GntR family transcriptional regulator	complement(194144..194938)	Mycobacterium tuberculosis H37Rv	886818
NP_214680.1	CDS	fadD5	NC_000962.2	194993	196657	D	activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase	194993..196657	Mycobacterium tuberculosis H37Rv	886822
NP_214681.1	CDS	yrbE1A	NC_000962.2	196861	197658	D	Rv0167, (MTCI28.07), len: 265 aa. yrbE1A, hypothetical unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar or similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 328, E(): 1.8e-15, (26.6% identity in 244 aa overlap); etc.; integral membrane protein YRBE1A	196861..197658	Mycobacterium tuberculosis H37Rv	886816
NP_214682.1	CDS	yrbE1B	NC_000962.2	197660	198529	D	Rv0168, (MTCI28.08), len: 289 aa. yrbE1B, hypothetical unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 223, E(): 7.6e-07, (23.7% identity in 257 aa overlap); etc.; integral membrane protein YRBE1B	197660..198529	Mycobacterium tuberculosis H37Rv	886812
YP_177701.1	CDS	mce1A	NC_000962.2	198534	199898	D	Rv0169, (MTCI28.09), len: 454 aa. mce1A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa); NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene product from Mycobacterium avium (88 aa) (similarity on C-terminus); CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa); etc. Note that equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901 Mcep protein from Mycobacterium tuberculosis (432 aa). Contains a very hydrophobic region around residues 20-35. Note that previously known as mce1.; mce1; MCE-family protein MCE1A	198534..199898	Mycobacterium tuberculosis H37Rv	886823
NP_214684.1	CDS	mce1B	NC_000962.2	199895	200935	D	Rv0170, (MTCI28.10), len: 346 aa. mce1B (alternate gene name: mceD); belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); CAC12797.1|AL445327 putative secreted protein from Streptomyces coelicolor (354 aa); etc. Contains hydrophobic region in N-terminal 30 residues. In Escherichia coli, N-terminal part is functional and directs export of a leaderless beta-lactamase into the periplasm (see Chubb et al., 1998).; mceD; MCE-family protein MCE1B	199895..200935	Mycobacterium tuberculosis H37Rv	886810
NP_214685.1	CDS	mce1C	NC_000962.2	200932	202479	D	Rv0171, (MTCI28.11), len: 515 aa. mce1C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); etc. Weakly similar to downstream ORF Rv0172|MTCI28.12|mce1D (530 aa), FASTA score: (24.6% identity in 552 aa overlap). Contains possible signal sequence and highly proline-rich C-terminus.; MCE-family protein MCE1C	200932..202479	Mycobacterium tuberculosis H37Rv	886808
NP_214686.1	CDS	mce1D	NC_000962.2	202476	204068	D	Rv0172, mce1D (MTCI28.12), len: 530 aa. mce1D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Hydrophobic region at N-terminus.; MCE-family protein MCE1D	202476..204068	Mycobacterium tuberculosis H37Rv	886807
NP_214687.1	CDS	lprK	NC_000962.2	204065	205237	D	Rv0173, (MTCI28.13), len: 390 aa. Possible lprK (alternate gene name: mce1E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa); CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa); etc. Contains PS00013 prokaryotic membrane lipoprotein lipid attachment site.; mce1E; MCE-family lipoprotein LprK	204065..205237	Mycobacterium tuberculosis H37Rv	886804
NP_214688.1	CDS	mce1F	NC_000962.2	205231	206778	D	Rv0174, (MTCI28.14), len: 515 aa. mce1F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), similar to Mycobacterium tuberculosis proteins O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from Mycobacterium avium (80 aa) (similarity on C-terminus); CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa); etc. Has hydrophobic stretch, possibly a signal peptide at the N-terminus.; MCE-family protein MCE1F	205231..206778	Mycobacterium tuberculosis H37Rv	886820
NP_214689.1	CDS	Rv0175	NC_000962.2	206814	207455	D	Rv0175, (MTCI28.15), len: 213 aa. Probable conserved Mce-associated membrane protein, equivalent, but longer in N-terminus, to CAC32127.1|AL583926 possible membrane protein from Mycobacterium leprae (182 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv1973, etc. Contains two 12 residue direct repeats at N-terminus.; mce associated membrane protein	206814..207455	Mycobacterium tuberculosis H37Rv	886801
NP_214690.1	CDS	Rv0176	NC_000962.2	207452	208420	D	Rv0176, (MTCI28.16), len: 322 aa. Probable conserved Mce-associated transmembrane protein. Contains short region of similarity to PRA_MYCLE|P41484 proline-rich antigen (36 kDa antigen) from Mycobacterium leprae (249 aa) (outside the proline-rich region), FASTA scores: opt: 165, E(): 2.9e-05, (40.0% identity in 65 aa overlap). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv3493c, etc.; mce associated transmembrane protein	207452..208420	Mycobacterium tuberculosis H37Rv	886799
NP_214691.1	CDS	Rv0177	NC_000962.2	208417	208971	D	Rv0177, (MTCI28.17), len: 184 aa. Probable conserved Mce-associated protein, equivalent to CAC32129.1|AL583926 conserved membrane protein from Mycobacterium leprae (184 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv1973, Rv3493c, etc.; MCE associated protein	208417..208971	Mycobacterium tuberculosis H37Rv	886795
NP_214692.1	CDS	Rv0178	NC_000962.2	208938	209672	D	Rv0178, (MTCI28.18), len: 244 aa. Probable conserved Mce-associated membrane protein, highly similar in C-terminus to CAC32130.1|AL583926 putative secreted protein from Mycobacterium leprae (184 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv1973, etc. Note that there is a 10 aa overlap with the upstream ORF.; mce associated membrane protein	208938..209672	Mycobacterium tuberculosis H37Rv	886814
NP_214693.1	CDS	lprO	NC_000962.2	209703	210812	R	Rv0179c, (MTCI28.19c), len: 369 aa. Possible lprO, lipoprotein (visibly not conserved). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LprO	complement(209703..210812)	Mycobacterium tuberculosis H37Rv	886796
NP_214694.1	CDS	Rv0180c	NC_000962.2	210892	212250	R	Rv0180c, (MTCI28.20c), len: 452 aa. Probable conserved transmembrane protein, equivalent to CAC32132.1|AL583926 probable conserved membrane protein from Mycobacterium leprae (465 aa). Shows some similarity with others membrane proteins e.g. AL096849|SCI11_29 from Streptomyces coelicolor (354 aa), FASTA scores: opt: 190, E(): 0.00067, (25.9% identity in 409 aa overlap).; transmembrane protein	complement(210892..212250)	Mycobacterium tuberculosis H37Rv	886792
NP_214695.1	CDS	Rv0181c	NC_000962.2	212277	213011	R	Rv0181c, (MTCI28.21c), len: 244 aa. Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. YHHW_ECOLI|P46852 hypothetical 26.3 kd protein from Escherichia coli (231 aa), FASTA scores: opt: 479, E(): 1.2e-29, (37.3% identity in 233 aa overlap); P73623|SLL1773 HYPOTHETICAL 25.7 kDa PROTEIN from Synechocystis sp. strain PCC 6803 (232 aa), FASTA score: (39.1% identity in 233 aa overlap).; hypothetical protein	complement(212277..213011)	Mycobacterium tuberculosis H37Rv	886788
NP_214696.1	CDS	sigG	NC_000962.2	213028	214140	R	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase factor sigma-70	complement(213028..214140)	Mycobacterium tuberculosis H37Rv	886786
NP_214697.2	CDS	Rv0183	NC_000962.2	214088	214927	D	Rv0183, (MTCI28.23), len: 279 aa. Possible lysophospholipase (EC 3.1.-.-), similar to several (especially eukaryotic enzymes, weaker with Escherichia coli), e.g. U67963|HSU67963_1 Human lysophospholipase homolog from Homo sapiens (313 aa), FASTA scores: opt: 569, E(): 2.6e-29, (37.1% identity in 259 aa overlap); P07000|PLDB_ECOLI LYSOPHOSPHOLIPASE L2 from Escherichia coli (165 aa), FASTA scores: opt: 219, E(): 0.00012. Start changed based on similarity to AE001997_8 from Deinococcus radiodurans (282 aa), FASTA scores: opt: 510, E(): 1.4e-25, (34.8% identity in 282 aa overlap). Also shows some similarity to epoxide hydrolases from Mycobacterium tuberculosis e.g. Rv1938 FASTA score: (30.7% identity in 114 aa overlap); and O07214|YR15_MYCTU|Rv2715|MT2788|MTCY05A6.36 (341 aa).; lysophospholipase	214088..214927	Mycobacterium tuberculosis H37Rv	886785
NP_214698.1	CDS	Rv0184	NC_000962.2	214969	215718	D	Rv0184, (MTCI28.24), len: 249 aa. Conserved hypothetical protein, equivalent to CAC32136.1|AL583926 conserved hypothetical protein from Mycobacterium lepra (249 aa); and C-terminus highly similar to CAB08793.1|Z95398 conserved hypothetical protein from Mycobacterium leprae (145 aa), FASTA scores: E(): 0, (75.2 identity in 145 aa overlap). Also similar to 049841|SCE9_39|T36358 hypothetical protein from Streptomyces coelicolor (418 aa), FASTA scores: opt: 231, E(): 8.1e-08, (30.4% identity in 270 aa overlap).; hypothetical protein	214969..215718	Mycobacterium tuberculosis H37Rv	886806
NP_214699.1	CDS	Rv0185	NC_000962.2	215715	216224	D	Rv0185, (MTCI28.25a), len: 169 aa. Conserved hypothetical protein, equivalent to CAB08794.1|Z95398|MLCL622_2 from Mycobacterium leprae (168 aa), FASTA scores: opt: 861, E(): 0, (76.4% identity in 165 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.; hypothetical protein	215715..216224	Mycobacterium tuberculosis H37Rv	886782
NP_214700.1	CDS	bglS	NC_000962.2	216269	218344	D	Rv0186, (MTCI28.25b), len: 691 aa. Probable bglS, beta-glucosidase (EC 3.2.1.21), highly similar to many e.g. BGLS_AGRTU|P27034 beta-glucosidase from Agrobacterium tumefaciens (818 aa), FASTA scores: opt: 643, E(): 0, (32.5% identity in 842 aa overlap). SEEMS TO BELONG TO FAMILY 3 OF GLYCOSYL HYDROLASES.; beta-glucosidase	216269..218344	Mycobacterium tuberculosis H37Rv	886780
NP_214701.1	CDS	Rv0187	NC_000962.2	218705	219367	D	Rv0187, (MTCI28.26), len: 220 aa. Probable O-methyltransferase (EC 2.1.1.-), similar to many e.g. AB93458.1|AL357591 putative O-methyltransferase from Streptomyces coelicolor (223 aa); MDMC_STRMY|Q00719 O-methyltransferase from Streptomyces mycarofaciens (221 aa), FASTA scores: opt: 327, E(): 2.4e-17, (35.9% identity in 192 aa overlap). Also similar to Rv1703c, Rv1220c from Mycobacterium tuberculosis.; O-methyltransferase	218705..219367	Mycobacterium tuberculosis H37Rv	886779
NP_214702.1	CDS	Rv0188	NC_000962.2	219486	219917	D	Rv0188, (MTCI28.27), len: 143 aa. Probable conserved transmembrane protein, similar to T35347|4835334|CAB42956.1|AL049863|SC5H1_31 probable membrane protein from Streptomyces coelicolor (147 aa), FASTA scores: opt: 326, E(): 6.5e-15, (36.2% identity in 141 aa overlap); N-terminus of P80185|MTRC_METTH TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT C (EC 2.1.1.86) from Methanobacterium thermoautotrophicum strain Marburg/DSM 2133 (266 aa), FASTA scores: opt: 125, E(): 0.033, (31.6% identity in 98 aa overlap). Also similar to Rv3635 from Mycobacterium tuberculosis.; transmembrane protein	219486..219917	Mycobacterium tuberculosis H37Rv	886776
NP_214703.1	CDS	ilvD	NC_000962.2	219996	221723	R	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase	complement(219996..221723)	Mycobacterium tuberculosis H37Rv	886774
NP_214704.1	CDS	Rv0190	NC_000962.2	221871	222161	D	Rv0190, (MTCI28.29), len: 96 aa. Conserved hypothetical protein, highly similar to several hypothetical proteins e.g. SYCSLRA_35|Q55554|SLL0176 hypothetical 18.9 kDa protein from Synechocystis (167 aa), FASTA scores: opt: 237, E(): 5.8e-16, (39.4% identity in 94 aa overlap). Also highly similar to Z95398|MLCL622_7|O06070 from Mycobacterium leprae (135 aa), FASTA score: (82.6% identity in 92 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0967, Rv0030, Rv1766 (42.5% identity in 80 aa overlap).; hypothetical protein	221871..222161	Mycobacterium tuberculosis H37Rv	886772
NP_214705.1	CDS	Rv0191	NC_000962.2	222289	223530	D	Rv0191, (MTCI28.30), len: 413 aa. Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug, similar to several hypothetical proteins e.g. YDEA_ECOLI|P31122 hypothetical 42.5 kd protein from Escherichia coli (396 aa), FASTA scores: opt: 475, E(): 4.2e-33, (29.7% identity in 381 aa overlap); and to several chloramphenicol resistance proteins e.g. CMLR_STRLI|P31141 chloramphenicol resistance protein from stremtomyces lividans (392 aa), FASTA scores: opt: 394, E(): 6.7e-12, (28.2% identity in 383 aa overlap). Also similar to SVU09991_1 from Mycobacterium tuberculosis.; integral membrane protein	222289..223530	Mycobacterium tuberculosis H37Rv	886770
NP_214706.1	CDS	Rv0192	NC_000962.2	223564	224664	D	Rv0192, (MTCI28.31), len: 366 aa. Conserved hypothetical protein. Has Gly- Arg-rich region followed by highly Pro-rich repetitive region near N-terminus. Similar in C-terminus to other hypothetical proteins e.g. Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 aa), FASTA scores: opt: 375, E(): 3.2e-24, (36.1% identity in 255 aa overlap); YV09_MYCTU|Q11149|cY20G9.09 hypothetical 47.9 kDa protein from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: 330, E(): 3.2e-13, (35.1% identity in 271 aa overlap). Also similar to Rv0116c, Rv1433, Rv2518c, Rv0483 from Mycobacterium tuberculosis.; hypothetical protein	223564..224664	Mycobacterium tuberculosis H37Rv	886768
YP_177618.1	CDS	Rv0192A	NC_000962.2	223607	223909	D	Rv0192A, len: 100 aa. Probable N-terminal part of Rv0192, which is member of family P5.17 with Rv0116c, Rv1433, Rv2518c, Rv0483. These are all predicted to be exported/membrane proteins. Rv0192A has typical N-terminal signal peptide which is functional and was identified by PhoA fusion screens: O52054 PGB14T-O1 PRECURSOR (FRAGMENT 45 AA) (see citation below). Since Rv0192 misses a signal peptide this suggests that there is a frameshift in the region of the overlap with Rv0192 but none found on reinspection of sequence.; hypothetical protein	223607..223909	Mycobacterium tuberculosis H37Rv	3205105
NP_214707.1	CDS	Rv0193c	NC_000962.2	224724	226571	R	Rv0193c, (MTV033.01c-MTCI28.32), len: 615 aa. Hypothetical unknown protein. TBparse score is 0.924.; hypothetical protein	complement(224724..226571)	Mycobacterium tuberculosis H37Rv	886764
NP_214708.1	CDS	Rv0194	NC_000962.2	226878	230462	D	Rv0194, (MTV033.02), len: 1194 aa. Probable drugs-transport transmembrane protein ATP binding protein ABC transporter (see citation below), highly similar to many e.g. U62129|STU62129_2|T30293 ABC transport protein homolog from Salmonella typhi (1218 aa), FASTA scores: opt: 1116, E(): 0, (36.3% identity in 1209 aa overlap); CAB66302.1|AL136519 ABC transporter protein ATP-binding component from Streptomyces coelicolor (1243 aa); I84547 mdl protein from Escherichia coli (1143 aa); etc. Also similar to MTCY50_9 and MTCY50_10 from Mycobacterium tuberculosis, FASTA score: (33.8% identity in 574 aa overlap). Contains two PS00017 ATP/GTP-binding site motif A (P-loop) and one PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Alternative start possible at 1823 but no RBS.; drugs-transport transmembrane ATP-binding protein ABC transporter	226878..230462	Mycobacterium tuberculosis H37Rv	886790
NP_214709.1	CDS	Rv0195	NC_000962.2	230899	231534	D	Rv0195, (MTV033.03), len: 211 aa. Possible two-component response regulator, luxR family, similar to many e.g. U00008|ECOHU49_15 regulatory protein narP from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 232, E(): 7.3e-09, (29.2% identity in 219 aa overlap). Start chosen by similarity. Contains probable helix-turn-helix motif at aa 166-187 (Score 1164, +3.15 SD). TBparse score is 0.931.; two component transcriptional regulatory protein	230899..231534	Mycobacterium tuberculosis H37Rv	886762
NP_214710.1	CDS	Rv0196	NC_000962.2	231647	232231	D	Rv0196, (MTV033.04), len: 194 aa. Possible transcriptional regulatory protein, similar to two Bacillus subtilis regulators: P42105|YXAF_BACSU HYPOTHETICAL 21.0 kDa PROTEIN (191 aa), FASTA scores: opt: 323, E(): 2.1e-15, (30.9% identity in 181 aa overlap); and Z99105|BSUB0002_9 negative regulator of the lincomycin operon (188 aa), FASTA scores: opt: 255, E(): 1e-10, (25.9 identity in 185 aa overlap). TBparse score is 0.885.; transcriptional regulatory protein	231647..232231	Mycobacterium tuberculosis H37Rv	886760
NP_214711.1	CDS	Rv0197	NC_000962.2	232231	234519	D	Rv0197, (MTV033.05), len: 762 aa. Possible oxidoreductase (EC 1.-.-.-), similar to others e.g. 9948789|AAG06102.1|AE004699_7|B83307 probable molybdopterin oxidoreductase from Pseudomonas aeruginosa strain PAO1 (769 aa); 5441785|CAB46809.1|AL096811|T36812 probable dehydrogenase from Streptomyces coelicolor (747 aa), FASTA scores: opt: 617, E(): 9.8e-30, (29.9% identity in 762 aa overlap); BAB04334.1|AP001509 assimilatory nitrate reductase (catalytic subunit) from Bacillus halodurans (743 aa); etc. TBparse score is 0.911.; oxidoreductase	232231..234519	Mycobacterium tuberculosis H37Rv	886758
NP_214712.1	CDS	Rv0198c	NC_000962.2	234516	236507	R	Rv0198c, (MTV033.06c), len: 663 aa. Probable zinc metalloprotease (EC 3.4.24.-), equivalent to Z95398|MLCL622.12c from Mycobacterium leprae (667 aa), FASTA scores: opt: 3710, E(): 0, (80.8 % identity in 667 aa overlap). Also similar to many other metalloproteases e.g. members of the eukaryotic neprilysin family: P08473|NEP_HUMAN NEPRILYSIN (EC 3.4.24.11) (749 aa), FASTA scores: opt: 872, E(): 0, (31.1% identity in 692 aa overlap); Q07744|PEPO_LACLA NEUTRAL ENDOPEPTIDASE from Lactococcus lactis (626 aa), FASTA scores: opt: 862, E(): 0, (30.0% identity in 654 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M13 (ZINC METALLOPROTEASE); ALSO KNOWN AS THE NEPRILYSIN SUBFAMILY. TBparse score is 0.905.; zinc metalloprotease	complement(234516..236507)	Mycobacterium tuberculosis H37Rv	886755
NP_214713.1	CDS	Rv0199	NC_000962.2	236550	237209	D	Rv0199, (MTV033.07), len: 219 aa. Probable conserved membrane protein, equivalent to Z95398|MLCL622.13 from Mycobacterium leprae (224 aa), FASTA scores: opt: 920, E(): 0, (67.7% identity in 220 aa overlap). Also some similarity to Mce-associated membrane proteins from Mycobacterium tuberculosis e.g. Rv0178, Rv0175, etc. TBparse score is 0.918.; hypothetical protein	236550..237209	Mycobacterium tuberculosis H37Rv	886753
NP_214714.1	CDS	Rv0200	NC_000962.2	237206	237895	D	Rv0200, (MTV033.08), len: 229 aa. Possible conserved transmembrane protein, equivalent to Z95398|MLCL622.14 from Mycobacterium leprae (229 aa), FASTA scores: opt: 1147, E(): 0, (74.7% identity in 229 aa overlap). Also some similarity to Rv1973 from Mycobacterium tuberculosis (160 aa); and Rv1362c|Z75555|MTCY02B10_26 (220 aa), FASTA scores: opt: 134, E(): 0.063, (25.8% identity in 159 aa overlap). TBparse score is 0.906.; transmembrane protein	237206..237895	Mycobacterium tuberculosis H37Rv	886803
NP_214715.1	CDS	Rv0201c	NC_000962.2	237892	238395	R	Rv0201c, (MTV033.09c), len: 167 aa. Conserved hypothetical protein, equivalent to Z95398|MLCL622.15c from Mycobacterium leprae (170 aa), FASTA scores: opt: 646, E(): 0, (63.9% identity in 158 aa overlap). TBparse score is 0.909.; hypothetical protein	complement(237892..238395)	Mycobacterium tuberculosis H37Rv	886756
NP_214716.1	CDS	mmpL11	NC_000962.2	238392	241292	R	Rv0202c, (MTV033.10c), len: 966 aa. Probable mmpL11, conserved transmembrane transport protein (see citation below), equivalent to Z95398|MLCL622.16c from Mycobacterium leprae (1014 aa), FASTA scores: opt: 4076, E(): 0, (72.8% identity in 1017 aa overlap). Member of RND superfamily, similar to several putative transport proteins e.g. P96687 from Bacillus subtilis (724 aa), FASTA scores: opt: 594, E(): 9.1e-29, (26.9% identity in 717 aa overlap); etc. BELONGS TO THE MMPL FAMILY. TBparse score is 0.913.; transmembrane transport protein MmpL11	complement(238392..241292)	Mycobacterium tuberculosis H37Rv	886750
NP_214717.1	CDS	Rv0203	NC_000962.2	241514	241924	D	Rv0203, (MTV033.11), len: 136 aa. Possible exported protein (has hydrophobic stretch near N-terminus). Some similarity to part of U02459|LDU02459_1 hypothetical protein from Leishmania donovani (741 aa), FASTA score: opt: 111, E(): 9.1, (30.0% identity in 90 aa overlap). TBparse score is 0.901.; hypothetical protein	241514..241924	Mycobacterium tuberculosis H37Rv	886748
NP_214718.1	CDS	Rv0204c	NC_000962.2	241976	243214	R	Rv0204c, (MTV033.12c), len: 412 aa. Probable conserved transmembrane protein (see citation below), equivalent, but has C-terminal extension, to Z95398|MLCL622.17c from Mycobacterium leprae (367 aa), FASTA scores: opt: 2002, E(): 0, (82.4% identity in 374 aa overlap). Some similarity to Rv0585c from Mycobacterium tuberculosis. TBparse score is 0.908.; transmembrane protein	complement(241976..243214)	Mycobacterium tuberculosis H37Rv	886747
NP_214719.1	CDS	Rv0205	NC_000962.2	243384	244487	D	Rv0205, (MTV033.13), len: 367 aa. Possible conserved transmembrane protein, similar to hypothetical proteins from many bacteria e.g. AL0209|SC4H8_6 from Streptomyces coelicolor (402 aa), FASTA scores: opt: 436, E(): 1.7e-21, (27.2% identity in 349 aa overlap); Z99117|BSUB0014_221 from Bacillus subtilis (353 aa), FASTA scores: opt: 394, E(): 8.6e-19, (28.7% identity in 324 aa overla). TBparse score is 0.885.; transmembrane protein	243384..244487	Mycobacterium tuberculosis H37Rv	886766
NP_214720.1	CDS	mmpL3	NC_000962.2	244484	247318	R	Rv0206c, (MTV033.14c, MTCY08D5.01c), len: 944 aa. Possible mmpL3, conserved transmembrane transport protein (see Tekaia et al., 1999), equivalent to Z95398|MLCL622.18c from Mycobacterium leprae (955 aa), FASTA scores: opt: 806, E(): 1.8e-21, (57.2% identity in 243 aa overlap). Member of RND superfamily, similar to others. BELONGS TO THE MMPL FAMILY. TBparse score is 0.928.; transmembrane transport protein MmpL3	complement(244484..247318)	Mycobacterium tuberculosis H37Rv	886752
NP_214721.1	CDS	Rv0207c	NC_000962.2	247384	248112	R	Rv0207c, (MTCY08D5.02c), len: 242 aa. Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap).; hypothetical protein	complement(247384..248112)	Mycobacterium tuberculosis H37Rv	886742
NP_214722.1	CDS	trmB	NC_000962.2	248115	248906	R	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase	complement(248115..248906)	Mycobacterium tuberculosis H37Rv	886740
NP_214723.1	CDS	Rv0209	NC_000962.2	249038	250123	D	Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical unknown protein.; hypothetical protein	249038..250123	Mycobacterium tuberculosis H37Rv	886739
NP_214724.1	CDS	Rv0210	NC_000962.2	250120	251598	D	Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381.; hypothetical protein	250120..251598	Mycobacterium tuberculosis H37Rv	886735
NP_214725.1	CDS	pckA	NC_000962.2	251782	253602	D	catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase	251782..253602	Mycobacterium tuberculosis H37Rv	886744
NP_214726.1	CDS	nadR	NC_000962.2	253669	254640	R	Rv0212c, (MTCY08D5.07c), len: 323 aa. Possible nadR (alternate gene name: nadI), transcriptional regulator, similar to others e.g. NADR_ECOLI|P27278 transcriptional regulator from Escherichia coli (410 aa), FASTA scores: opt: 377, E (): 1e-17, (31.1% identity in 347 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; nadI; transcriptional regulatory protein NadR	complement(253669..254640)	Mycobacterium tuberculosis H37Rv	886734
NP_214727.1	CDS	Rv0213c	NC_000962.2	254637	255950	R	Rv0213c, (MTCY08D5.08c), len: 437 aa. Possible methyltransferase (EC 2.1.1.-), weakly similar to others methyltransferases e.g. AF127374_30|LINA from Streptomyces lavendulae (611 aa), FASTA scores: opt: 400, E(): 8.1e-19, (27.3% identity in 388 aa overlap); Q50258 fortimicin kl1 methyltransferase (553 aa), FASTA scores: opt: 267, E(): 1.2e-13, (29.3% identity in 351 aa overlap).; methyltransferase (methylase)	complement(254637..255950)	Mycobacterium tuberculosis H37Rv	886746
NP_214728.1	CDS	fadD4	NC_000962.2	256064	257677	D	activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase	256064..257677	Mycobacterium tuberculosis H37Rv	886737
NP_214729.1	CDS	fadE3	NC_000962.2	257783	258856	R	Rv0215c, (MTCY08D5.10c), len: 357 aa. Probable fadE3, acyl- dehydrogenase (EC 1.3.99.-), similar to many e.g. ACDB_BACSU|P45857 acyl-CoA dehydrogenase from B. subtilis (EC 1.3.99.-) (379 aa), FASTA scores: opt: 812, E(): 0, (39.5% identity in 354 aa overlap).; acyl-CoA dehydrogenase FADE3	complement(257783..258856)	Mycobacterium tuberculosis H37Rv	886730
NP_214730.1	CDS	Rv0216	NC_000962.2	258913	259926	D	Rv0216, (MTCY08D5.11), len: 337 aa. Conserved hypothetical protein, equivalent to Z95398|MLCL622_22 from Mycobacterium leprae (339 aa), FASTA scores: E(): 0, (73.7 identity in 338 aa overlap).; hypothetical protein	258913..259926	Mycobacterium tuberculosis H37Rv	886729
NP_214731.1	CDS	lipW	NC_000962.2	259923	260831	R	Rv0217c, (MTCY08D5.12c), len: 302 aa. Possible esterase (EC 3.1.1.-), showing similarity with others e.g. EST_ACICA|P18773 esterase (303 aa), FASTA scores: opt: 320, E(): 3.2e-13, (29.2% identity in 274 aa overlap).; esterase LipW	complement(259923..260831)	Mycobacterium tuberculosis H37Rv	886726
NP_214732.1	CDS	Rv0218	NC_000962.2	260924	262252	D	Rv0218, (MTCY08D5.13), len: 442 aa. Probable conserved transmembrane protein, some similarity with sulfite oxidases (EC 1.8.3.1) e.g. SUOX_HUMAN|P51687 sulfite oxidase precursor (488 aa), FASTA scores: opt: 153, E(): 0.0087, (28.6% identity in 161 aa overlap); and with some nitrate reductases (EC 1.6.6.3) e.g. NIA_FUSOX|P39863 nitrate reductase (NADPH) (905 aa), FASTA scores: opt: 143, E(): 0.06, (29.3% identity in 92 aa overlap). Also similar to BSUB0017_86 from Mycobacterium tuberculosis.; transmembrane protein	260924..262252	Mycobacterium tuberculosis H37Rv	886727
NP_214733.1	CDS	Rv0219	NC_000962.2	262254	262802	D	Rv0219, (MTCY08D5.14), len: 182 aa. Probable conserved transmembrane protein, showing similarity with CAB76992.1|AL159178 putative lipoprotein from Streptomyces coelicolor (163 aa).; transmembrane protein	262254..262802	Mycobacterium tuberculosis H37Rv	886725
NP_214734.1	CDS	lipC	NC_000962.2	262812	264023	D	Rv0220, (MTCY08D5.15), len: 403 aa. Probable esterase (EC 3.1.1.-), similar to others proteins and esterases from various organisms and Mycobacterium tuberculosis e.g. Q50681 (431 aa), FASTA scores: opt: 841, E(): 0, (38.2% identity in 408 aa overlap); Rv1426c, Rv1399c, etc. Contains PS00122 Carboxylesterases type-B serine active site.; esterase LipC	262812..264023	Mycobacterium tuberculosis H37Rv	886722
NP_214735.1	CDS	Rv0221	NC_000962.2	264067	265476	D	Rv0221, (MTCY08D5.16), len: 469 aa. Conserved hypothetical protein, similar to others proteins from Mycobacterium tuberculosis e.g. Q50680|Rv2285|MT2343|MTCY339.25c hypothetical 47.7 kDa protein (445 aa), FASTA scores: opt: 455, E(): 8.1e-23, (26.7% identity in 461 aa overlap); Rv3740c, Rv3734c, etc.; hypothetical protein	264067..265476	Mycobacterium tuberculosis H37Rv	886719
NP_214736.1	CDS	echA1	NC_000962.2	265507	266295	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	265507..266295	Mycobacterium tuberculosis H37Rv	886723
NP_214737.1	CDS	Rv0223c	NC_000962.2	266301	267764	R	Rv0223c, (MTCY08D5.18), len: 487 aa. Probable aldehyde dehydrogenase (EC 1.2.1.-), similar to others e.g. A75608|6460525|AAF12231.1|AE001862_57 aldehyde dehydrogenase from Deinococcus radiodurans strain R1 (495 aa); Q47943 L-sorbosone dehydrogenase NAD(P) dependent from Gluconobacter oxydans (498 aa), FASTA scores: opt: 1157, E (): 0, (42.1% identity in 482 aa overlap); etc. Also similar to Rv0768, Rv2858c, etc from Mycobacterium tuberculosis. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site; and PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.; aldehyde dehydrogenase	complement(266301..267764)	Mycobacterium tuberculosis H37Rv	886718
NP_214738.1	CDS	Rv0224c	NC_000962.2	267863	268627	R	Rv0224c, (MTCY08D5.19c), len: 254 aa. Possible methyltransferase (EC 2.1.1.-), showing weak similarity with other methyltransferases e.g. P74388 STEROL-C-METHYLTRANSFERASE (318 aa), FASTA scores: opt: 190, E(): 3.6e-05, (33.3% identity in 114 aa overlap). Equivalent to AL022486|MLCB1883_1 from Mycobacterium leprae (269 aa), FASTA scores: opt: 1456, E(): 0, (82.9% identity in 252 aa overlap). Also some similarity with MTCY21B4.22c from Mycobacterium tuberculosis FASTA score: (30.1% identity in 136 aa overlap).; methyltransferase (methylase)	complement(267863..268627)	Mycobacterium tuberculosis H37Rv	886715
NP_214739.1	CDS	Rv0225	NC_000962.2	268663	269817	D	Rv0225, (MTCY08D5.20), len: 384 aa. Possible conserved protein involved in LPS biosynthesis, similar to O26275 LPS BIOSYNTHESIS RFBU RELATED PROTEIN (382 aa), FASTA scores: opt: 426, E(): 1.2e-20, (28.2% identity in 394 aa overlap). Some similarity with Rv3032 from Mycobacterium tuberculosis FASTA score: (31.6% identity in 228 aa overlap).; hypothetical protein	268663..269817	Mycobacterium tuberculosis H37Rv	886713
NP_214740.1	CDS	Rv0226c	NC_000962.2	269834	271564	R	Rv0226c, (MTCY08D5.21c), len: 576 aa. Probable conserved transmembrane protein, equivalent, except in N-terminal part, to AC32114.1|AL583926 conserved membrane protein from Mycobacterium leprae (600 aa), FASTA scores: opt: 2086, E(): 0, (70.3% identity in 579 aa overlap). Also similar to AL021411|SC7H1_20 from Streptomyces coelicolor (483 aa), FASTA scores: opt: 180, E(): 0.00028, (26.5 identity in 388 aa overlap).; transmembrane protein	complement(269834..271564)	Mycobacterium tuberculosis H37Rv	886711
NP_214741.1	CDS	Rv0227c	NC_000962.2	271574	272839	R	Rv0227c, (MTCY08D5.22c), len: 421 aa. Possible conserved membrane protein, equivalent to AL022486|MLCB1883_4 from Mycobacterium leprae (448 aa), FASTA scores: opt: 2148, E(): 0, (76.6% identity in 423 aa overlap).; hypothetical protein	complement(271574..272839)	Mycobacterium tuberculosis H37Rv	886710
NP_214742.1	CDS	Rv0228	NC_000962.2	273055	274278	D	Rv0228, (MTCY08D5.23), len: 407 aa. Probable integral membrane acyltransferase (EC 2.3.1.-), equivalent to 3063875|CAA18555.1|AL022486|T44870 ACYLTRANSFERASE from Mycobacterium leprae (384 aa), FASTA scores: opt: 2004, E(): 0, (79.3% identity in 381 aa overlap). Also similar to others e.g. Q11064 PROBABLE ACYLTRANSFERASE CY50.28C (383 aa), FASTA scores: opt: 372, E(): 2.6e-16, (35.9% identity in 359 aa overlap); Q00718|MDMB_STRMY ACYLTRANSFERASE. Very similar to Rv0111, Rv1254, etc from Mycobacterium tuberculosis.; integral membrane acyltransferase	273055..274278	Mycobacterium tuberculosis H37Rv	886708
NP_214743.1	CDS	Rv0229c	NC_000962.2	274306	274986	R	Rv0229c, (MTCY08D5.24c), len: 226 aa. Possible conserved membrane protein, similar to several proteins from Mycobacterium tuberculosis. Other possible start sites and could be shorter as C-terminal region has some similarity with Rv2757c|D70880 from Mycobacterium tuberculosis (138 aa), FASTA scores: E(): 1e-15, (45.3% identity in 137 aa overlap), and Rv0301, Rv2546, etc. Also some similarity with Q48177 virulence associated protein C (132 aa), FASTA scores: opt: 101, E(): 0.6, (24.3% identity in 136 aa overlap). Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.; hypothetical protein	complement(274306..274986)	Mycobacterium tuberculosis H37Rv	886724
NP_214744.1	CDS	php	NC_000962.2	274983	275963	R	Rv0230c, (MTCY08D5.26c), len: 326 aa. Probable php, phosphotriesterase (EC 3.1.8.1), similar to others e.g. AAK42653.1|AE006849 putative aryldialkylphosphatase (phosphotriesterase) (paraoxonase) from Sulfolobus solfataricus (314 aa); PHP_ECOLI|P45548 PHOSPHOTRIESTERASE HOMOLOGY PROTEIN from Escherichia coli (292 aa), FASTA scores: opt: 408, E(): 7.1e-20, (31.1% identity in 305 aa overlap ); OPD_FLASP|P16648 parathion hydrolase precursor (365 aa), FASTA scores: opt: 319, E(): 5.1e-14, (34.5% identity in 333 aa overlap); etc. BELONGS TO THE PHOSPHOTRIESTERASE FAMILY. COFACTOR: CONTAINS 2 MOLES OF ZINC PER SUBUNIT.; phosphotriesterase	complement(274983..275963)	Mycobacterium tuberculosis H37Rv	886705
NP_214745.1	CDS	fadE4	NC_000962.2	276058	277764	D	Rv0231, (MTCY08D5.27), len: 568 aa. Probable fadE4, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. O29752 ACYL-CoA DEHYDROGENASE (ACD-3) from Archaeoglobus fulgidus (576 aa), FASTA scores: opt: 1788, E(): 0, (51.0% identity in 577 aa overlap); ACDB_BACSU|P45857 acyl-coa dehydrogenase from Bacillus subtilis (379 aa), FASTA scores: opt: 232, E(): 2.2e- 08, (21.6% identity in 291 aa overlap).; acyl-CoA dehydrogenase FADE4	276058..277764	Mycobacterium tuberculosis H37Rv	886703
NP_214746.1	CDS	Rv0232	NC_000962.2	277899	278588	D	Rv0232, (MTCY08D5.28), len: 229 aa. Probable transcriptional regulatory protein, tetR/AcrR family, similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA scores: opt: 149, E(): 0.0014, (21.5% identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins, tetR family signature, and probable helix-turn helix motif from aa 33-54 (Score 1142, +3.08 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.; TetR/ACRR family transcriptional regulator	277899..278588	Mycobacterium tuberculosis H37Rv	886701
NP_214747.1	CDS	nrdB	NC_000962.2	278585	279529	D	Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit beta	278585..279529	Mycobacterium tuberculosis H37Rv	886699
NP_216247.2	CDS	gabD1	NC_000962.2	279605	281140	R	NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinic semialdehyde dehydrogenase	complement(279605..281140)	Mycobacterium tuberculosis H37Rv	886732
NP_214749.1	CDS	Rv0235c	NC_000962.2	281166	282614	R	Rv0235c, (MTCY08D5.31c), len: 482 aa. Probable conserved transmembrane protein, highly similar to AL133278|CAB61913.1|SCM11_2 putative integral membrane protein from Streptomyces coelicolor (470 aa), FASTA scores: opt: 2116, E(): 0, (61.8% identity in 474 aa overlap); and similar to hypothetical proteins from other organisms e.g. Q13392|384D8_7 hypothetical protein (579 aa), FASTA scores: opt: 355, E(): 6.9e-17, (28.5% identity in 569 aa overlap).; transmembrane protein	complement(281166..282614)	Mycobacterium tuberculosis H37Rv	886695
NP_214750.1	CDS	Rv0236c	NC_000962.2	282649	286851	R	Rv0236c, (MTV034.01c, MTV034.02c, MTCY08D5.32c), len: 1400 aa. Probable conserved transmembrane protein, equivalent to AL022486|CAC32102.1|MLCB1883_7 possible integral membrane protein from Mycobacterium leprae (1440 aa), FASTA scores: opt: 7491, E(): 0, (78.8% identity in 1397 aa overlap).; transmembrane protein	complement(282649..286851)	Mycobacterium tuberculosis H37Rv	886707
YP_177619.1	CDS	Rv0236A	NC_000962.2	286898	287071	R	Rv0236A, len: 57 aa. Small secreted protein.; hypothetical protein	complement(286898..287071)	Mycobacterium tuberculosis H37Rv	3205106
YP_177702.1	CDS	lpqI	NC_000962.2	287186	288352	D	Rv0237, (MTV034.03), len: 388 aa. Probable lpQI, conserved lipoprotein, equivalent to AL022486|MLCB1883_8|T44873 probable secreted hydrolase from Mycobacterium leprae (387 aa), FASTA scores: opt: 1831, E(): 0, (73.3% identity in 390 aa overlap). Also similar to other lipoproteins and various hydrolases e.g. P40406|2126897|YBBD_BACSU|I39839 HYPOTHETICAL 70.6 KDA LIPOPROTEIN from Bacillus subtilis (642 aa); P48823|HEXA_ALTSO BETA-HEXOSAMINIDASE A PRECURSOR from ALTEROMONAS SP. (598 aa), FASTA scores: opt: 415, E(): 5.8e-17, (31.2% identity in 343 aa overlap); PCC6803|P74340 BETA-GLUCOSIDASE from Synechocystis sp. (538 aa), FASTA scores: opt: 414, E(): 6.1e-17, (30.6 identity in 320 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LpqI	287186..288352	Mycobacterium tuberculosis H37Rv	886693
NP_214752.1	CDS	Rv0238	NC_000962.2	288428	289042	D	Rv0238, (MTV034.04), len: 204 aa. Possible transcriptional regulatory protein, TetR family, equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (208 aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in 199 aa overlap). Also similar to others e.g. CAB77290.1|AL160312 putative tetR-family regulatory protein from Streptomyces coelicolor (240 aa). Also similar to Mycobacterium tuberculosis proteins Z95120|Rv3208 (228 aa), FASTA scores: opt: 266, E(): 8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019 (197 aa).; TetR family transcriptional regulator	288428..289042	Mycobacterium tuberculosis H37Rv	886691
NP_214753.1	CDS	Rv0239	NC_000962.2	289104	289337	D	Rv0239, (MTV034.05), len: 77 aa. Conserved hypothetical protein, weakly similar to Rv1839c|Z83859|MTCY359_34 from Mycobacterium tuberculosis (87 aa), FASTA scores: opt: 88, E(): 5, (40.0% identity in 45 aa overlap). TBparse score is 0.922.; hypothetical protein	289104..289337	Mycobacterium tuberculosis H37Rv	886689
NP_214754.1	CDS	Rv0240	NC_000962.2	289345	289782	D	Rv0240, (MTV034.06), len: 145 aa. Conserved hypothetical protein, weak similarity with Rv3697c from Mycobacterium tuberculosis (145 aa), FASTA scores: opt: 145, E(): 7.6e-05, (28.0% identity in 143 aa overlap).; hypothetical protein	289345..289782	Mycobacterium tuberculosis H37Rv	886688
NP_214755.1	CDS	Rv0241c	NC_000962.2	289812	290654	R	Rv0241c, (MTV034.07c), len: 280 aa. Conserved hypothetical protein, highly similar to MLCB1883.17c|T44876063881|CAA18566.1|AL022486 hypothetical protein from Mycobacterium leprae (280 aa), FASTA scores: opt: 1564, E(): 0, (81.8% identity in 280 aa overlap); and CAC32097.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (300 aa). Also similar to proteins from other organisms e.g. CAB77291.1|AL160312 putative dehydratase from Streptomyces coelicolor (291 aa); part of BAA92930.1|AB032743 fatty acid synthetase beta subunit from Pichia angusta (2060 aa).; hypothetical protein	complement(289812..290654)	Mycobacterium tuberculosis H37Rv	886686
NP_214756.1	CDS	fabG	NC_000962.2	290665	292029	R	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase	complement(290665..292029)	Mycobacterium tuberculosis H37Rv	886697
NP_214757.1	CDS	fadA2	NC_000962.2	292171	293493	D	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase	292171..293493	Mycobacterium tuberculosis H37Rv	886682
NP_214758.1	CDS	fadE5	NC_000962.2	293798	295633	R	Rv0244c, (MTV034.10c), len: 611 aa. Probable fadE5, acyl-CoA dehydrogenase (EC 1.3.99.-), equivalent to AL022486|MLCB1883_15 from Mycobacterium leprae (611 aa), FASTA scores: opt: 3598, E(): 0, (89.4% identity in 611 aa overlap). Also highly similar to AL0211|MTV007.14 from Mycobacterium tuberculosis (609 aa), FASTA scores: opt: 2576, E(): 0, (64.6% identity in 611 aa overlap); and to various other bacterial proteins described as putative acyl-CoA dehydrogenases e.g. AE0010|AE001025_6 from Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 229, E(): 6.8e-08, (29.8% identity in 409 aa overlap); etc.; acyl-CoA dehydrogenase FADE5	complement(293798..295633)	Mycobacterium tuberculosis H37Rv	886698
NP_214759.1	CDS	Rv0245	NC_000962.2	296005	296493	D	Rv0245, (MTV034.11), len: 162 aa. Possible oxidoreductase (EC 1.-.-.-), equivalent to AL022486|MLCB1883_17|T44882 probable oxidoreductase from Mycobacterium leprae (162 aa), FASTA scores: opt: 860, E(): 0, (83.4% identity in 157 aa overlap). Also similar to several hypothetical proteins and various oxidoreductases e.g. AAK24246.1|AE005898 NADH:riboflavin 5'-phosphate oxidoreductase from Caulobacter crescentus (174 aa); Q02058|DIM6_STRCO|CAA45048.1 ACTINORHODIN POLYKETIDE DIMERASE from STREPTOMYCES COELICOLOR (177 aa), FASTA scores: opt: 308, E(): 3. 2e-15, (37.8% identity in 143 aa overlap). Also similar to Z84498|Rv1939|MTCY09F9.25c from Mycobacterium tuberculosis (171 aa), FASTA scores: opt: 517, E(): 3.5e-30, (49.4% identity in 158 aa overlap).; oxidoreductase	296005..296493	Mycobacterium tuberculosis H37Rv	886680
NP_214760.1	CDS	Rv0246	NC_000962.2	296809	298119	D	Rv0246, (MTV034.12), len: 436 aa (start uncertain). Probable conserved integral membrane protein, similar to Rv2209|1237062|CAA94252.1|Z70283|Q10398|YM09_MYCTU from Mycobacterium tuberculosis (512 aa), FASTA scores: opt: 712, E(): 0, (33.2% identity in 422 aa overlap).; integral membrane protein	296809..298119	Mycobacterium tuberculosis H37Rv	886678
NP_214761.1	CDS	Rv0247c	NC_000962.2	298116	298862	R	catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; fumarate reductase iron-sulfur subunit	complement(298116..298862)	Mycobacterium tuberculosis H37Rv	886677
NP_214762.1	CDS	sdhA	NC_000962.2	298863	300803	R	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit	complement(298863..300803)	Mycobacterium tuberculosis H37Rv	886675
NP_214763.1	CDS	Rv0249c	NC_000962.2	300834	301655	R	Rv0249c, (MTV034.15c), len: 273 aa. Probable succinate dehydrogenase, membrane-anchor subunit for succinate dehydrogenase encoded by Rv0247c and Rv0248c. Highly similar to AC44315.1|AL596043 putative integral membrane protein from Streptomyces coelicolor (278 aa). NOTE THAT SUCCINATE DEHYDROGENASE FORMS GENERALLY PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv0248c ?), AN IRON-SULFUR (Rv0247c ?), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv0249c ?).; succinate dehydrogenase membrane anchor subunit	complement(300834..301655)	Mycobacterium tuberculosis H37Rv	886671
NP_214764.1	CDS	Rv0250c	NC_000962.2	301735	302028	R	Rv0250c, (MTV034.16c), len: 97 aa. Conserved hypothetical protein, equivalent to MLCB1883.27c|T44883|3063888|CAA18576.1|AL022486 hypothetical protein from Mycobacterium leprae (98 aa), FASTA scores: opt: 478, E(): 4.4e-28, (72.6% identity in 95 aa overlap). Also similar to C-terminus of AC44316.1|AL596043|SCBAC31E11.05c hypothetical protein from Streptomyces coelicolor (146 aa).; hypothetical protein	complement(301735..302028)	Mycobacterium tuberculosis H37Rv	886669
NP_214765.1	CDS	hsp	NC_000962.2	302173	302652	R	Rv0251c, (MTV034.17c), len: 159 aa. hsp (alternate gene name: hsp20, hrpA, acr2), heat-stress-induced ribosome-binding protein A (see citations below). Highly similar to AAD39038.1|AF072875_1|AF072875 putative HSP20 from Mycobacterium smegmatis (145 aa), FASTA scores: opt: 479, E(): 2.3e-24, (59.9% identity in 157 aa overlap); and similar to many bacterial and eukaryotic hsp proteins e.g. P12811|HS2C_CHLRE CHLOROPLAST HEAT SHOCK 22KD PROTEIN from CHLAMYDOMONAS REINHARDTII (157 aa), FASTA scores: opt: 184, E(): 1.2e-05, (32.4% identity in 142 aa overlap). Also similar to PCC6803 Spore protein sp21 from Synechocystis sp. (146 aa), FASTA scores: opt: 213, E(): 1.2e-07, (30.3 identity in 145 aa overlap). Also similar to P30223|14KD_MYCTU 14 KDA ANTIGEN (16 KDA ANTIGEN) 19K major membrane protein (HSP 16.3) from Mycobacterium tuberculosis (144 aa). BELONG TO THE SMALL HEAT SHOCK PROTEIN (HSP20) FAMILY.; hsp 20; hrpA; acr2; heat shock protein hsp (heat-stress-induced ribosome-binding protein A)	complement(302173..302652)	Mycobacterium tuberculosis H37Rv	886667
NP_214766.1	CDS	nirB	NC_000962.2	302866	305427	D	Rv0252, (MTV034.18), len: 853 aa. Probable nirB (alternate gene name: nasB), nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4), flavoprotein containing siroheme and a 2FE-2S iron-sulfur centre. Highly similar to many others bacterial enzymes e.g. P08201|NIRB_ECOLI NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT from Escherichia coli strain K12 (847 aa), FASTA scores: opt: 2775, E(): 0, (49.8% identity in 840 aa overlap); Q06458|NIRB_KLEPN NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT (957 aa), FASTA scores: opt: 2902, E(): 0, (54.2% identity in 827 aa overlap). Contains PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. HOMODIMER WHICH ASSOCIATES WITH NIRD|Rv0253. COFACTORS: FAD; Iron; Siroheme. TBparse score is 0.903.; nasB; nitrite reductase large subunit	302866..305427	Mycobacterium tuberculosis H37Rv	886665
NP_214767.1	CDS	nirD	NC_000962.2	305453	305809	D	Rv0253, (MTV034.19), len: 118 aa. Probable nirD, nitrite reductase [NAD(P)H] small subunit (EC 1.6.6.4), similar to others e.g. P23675|NIRD_ECOLI|B3366|Z4727|ECS4217 from Escherichia coli strains K12 and O157:H7 (108 aa), FASTA scores: opt: 271, E():1.7e-12, (41.9% identity in 105 aa overlap). ASSOCIATES WITH NIRB|Rv0252. TBparse score is 0.913.; nitrite reductase [NAD(P)H] small subunit NirD	305453..305809	Mycobacterium tuberculosis H37Rv	886664
NP_214768.1	CDS	cobU	NC_000962.2	305825	306349	R	Rv0254c, (MTV034.20), len: 174 aa. Probable cobU, cobalamin biosynthesis protein including a cobinamide kinase (EC 2.-.-.-) and cobinamide phosphate guanylyltransferase (EC 2.-.-.-). Highly similar to many e.g. Q05599|COBU_SALTY COBINAMIDE KINASE / COBINAMIDE PHOSPHATE GUANYLYLTRANSFERASE from Salmonella typhimurium (181 aa), FASTA scores: opt: 308, E(): 1.1e-14, (38.7% identity in 181 aa overlap); P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional cobalamin biosynthesis protein cobU from Escherichia coli strains K12 and O157:H7 (181 aa); part of AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa), FASTA scores: opt: 445, E(): 3.6e-23, (46.0% identity in 176 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; bifunctional cobinamide kinase/cobinamide phosphate guanylyltransferase	complement(305825..306349)	Mycobacterium tuberculosis H37Rv	886661
YP_177703.1	CDS	cobQ1	NC_000962.2	306374	307858	R	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase	complement(306374..307858)	Mycobacterium tuberculosis H37Rv	886673
YP_177704.1	CDS	PPE2	NC_000962.2	307877	309547	R	Rv0256c, (MTV034.22c), len: 556 aa. Member of the M. tuberculosis PPE family, similar to many e.g. Rv0280, Rv0286, etc. Equivalent to Z98756|MLCB2492.30 from Mycobacterium leprae (572 aa), FASTA scores: opt: 1837, E(): 0, (62.9% identity in 461 aa overlap).; PPE family protein	complement(307877..309547)	Mycobacterium tuberculosis H37Rv	886684
YP_177620.1	CDS	Rv0257	NC_000962.2	309699	310073	D	Rv0257, len: 124 aa. Hypothetical protein, orthologue of ML1828A conserved hypothetical protein from Mycobacterium leprae. Replaced Rv0257c (older annotation).; hypothetical protein	309699..310073	Mycobacterium tuberculosis H37Rv	3205110
NP_214772.1	CDS	Rv0258c	NC_000962.2	310294	310749	R	Rv0258c, (MTCY06A4.02c), len: 151 aa (alternative start possible). Conserved hypothetical protein, showing some similarity to Rv1685c|MTCI125_6 from Mycobacterium tuberculosis (207 aa), FASTA scores: E(): 9.3e-07, (32.1% identity in 140 aa overlap). Also some similarity with AL049819|SCE7_13|T36295 probable transcription regulator from Streptomyces coelicolor (204 aa), FASTA scores: opt: 158, E(): 0.00052, (27.0% identity in 111 aa overlap).; hypothetical protein	complement(310294..310749)	Mycobacterium tuberculosis H37Rv	886654
NP_214773.1	CDS	Rv0259c	NC_000962.2	310774	311517	R	Rv0259c, (MTCY06A4.03c), len: 247 aa. Conserved hypothetical protein, showing some similarity to Rv2393|Z81368|MTCY253_28 from Mycobacterium tuberculosis (281 aa), FASTA scores: E(): 9.5e-16, (33.6 % identity in 235 aa overlap). Also some similarity with CAC33938.1|AL589708 putative secreted protein from Streptomyces coelicolor (248 aa).; hypothetical protein	complement(310774..311517)	Mycobacterium tuberculosis H37Rv	886657
NP_214774.1	CDS	Rv0260c	NC_000962.2	311514	312659	R	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; bifunctional uroporphyrinogen-III synthetase/response regulator domain protein	complement(311514..312659)	Mycobacterium tuberculosis H37Rv	886651
NP_214775.1	CDS	narK3	NC_000962.2	312759	314168	R	Rv0261c, (MTCY06A4.05c), len: 469 aa. Probable nirK3, nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS), equivalent to AAB41700.1|U72744 nitrite extrusion protein from Mycobacterium fortuitum (471 aa); and 2342627|CAB11406.1|Z98741|T44908 nitrite extrusion protein homolog from Mycobacterium leprae (517 aa; longer in N-terminus). Also similar to other nitrite extrusion proteins e.g. NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 755, E(): 0, (35.0% identity in 466 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS.; integral membrane nitrite extrusion protein NarK3	complement(312759..314168)	Mycobacterium tuberculosis H37Rv	886663
NP_214776.1	CDS	aac	NC_000962.2	314309	314854	R	Rv0262c, (MTCY06A4.06c), len: 181 aa. aac, aminoglycoside 2'-N-acetyltransferase (aac(2')-IC) (EC 2.3.1.-) (see citation below), highly similar to NP_302635.1|NC_002677 aminoglycoside 2'-N-acetyltransferase from Mycobacterium leprae (182 aa); Q49157|AAC2_MYCFO|AAC aminoglycoside 2'-N-acetyltransferase from Mycobacterium fortuitum (195 aa), FASTA scores: opt: 884, E(): 0, (69.1% identity in 181 aa overlap); and P94968|AAC2_MYCSM|AAC aminoglycoside 2'-N-acetyltransferase from Mycobacterium smegmatis (210 aa) (see also citation below). Also similar to Q52424|AAC2_PROST AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE from Providencia stuartii (178 aa). BELONGS TO THE AAC(2')-I FAMILY OF ACETYLTRANSFERASES. Note that previously known as aac(2')-IC.; aac(2')-IC; aminoglycoside 2'-N-acetyltransferase AAC (AAC(2')-IC)	complement(314309..314854)	Mycobacterium tuberculosis H37Rv	886648
NP_214777.1	CDS	Rv0263c	NC_000962.2	314864	315766	R	Rv0263c, (MTCY06A4.07c), len: 300 aa. Conserved hypothetical protein, equivalent to NP_302634.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (305 aa). Also similar to others e.g. AL121596|SC51A_21 hypothetical protein from Streptomyces coelicolor (285 aa), FASTA scores: opt: 714, E(): 0, (45.3% identity in 289 aa overlap); NP_233164.1|NC_002506 conserved hypothetical protein from Vibrio cholerae (309 aa); NP_406216.1|NC_003143 conserved hypothetical protein from Yersinia pestis (316 aa); YH30_HAEIN|P44298|hi1730 hypothetical protein from Haemophilus influenzae (309 aa), FASTA scores: opt: 430, E(): 3e-20, (29.6% identity in 284 aa overlap); etc. Also similar to carboxylases eg NP_415240.1|NC_000913|P75745|YBGK_ECOLI putative carboxylase from Escherichia coli strain K12 (310 aa), FASTA score: (34.6% identity in 286 aa overlap); NP_459698.1|NC_003197 putative carboxylase from Salmonella typhimurium (310 aa); and to middle part of NP_420636.1|NC_002696 urea amidolyase-related protein from Caulobacter crescentus (1207 aa).; hypothetical protein	complement(314864..315766)	Mycobacterium tuberculosis H37Rv	886659
NP_214778.1	CDS	Rv0264c	NC_000962.2	315783	316415	R	Rv0264c, (MTCY06A4.08c), len: 320 aa. Conserved hypothetical protein, equivalent to CAC32080.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (222 aa). Also similar to others hypothetical proteins e.g. AL121596|SC51A_20 from Streptomyces coelicolor (252 aa), FASTA scores: opt: 420, E(): 2.7e-20, (41.7% identity in 204 aa overlap); P75744|YBGJ_ECOLI HYPOTHETICAL 23.9 KD PROTEIN from Escherichia coli (218 aa), FASTA scores: E(): 2.1e-14, (35.7% identity in 182 aa overlap); YH31_HAEIN|P44299|hi173 hypothetical protein from Haemophilus influenzae (213 aa), FASTA scores: opt: 252, E(): 8.3e-10, (31.1% identity in 183 aa overlap).; hypothetical protein	complement(315783..316415)	Mycobacterium tuberculosis H37Rv	886646
YP_177705.1	CDS	Rv0265c	NC_000962.2	316511	317503	R	Rv0265c, (MTCY06A4.09c), len: 330 aa. Probable iron-transport lipoprotein, most similar to T36412|5763945|CAB53324.1|AL109974 probable iron-siderophore binding lipoprotein from Streptomyces coelicolor (350 aa); and (N-terminus may be incorrect) to T14166|3560508|AAC82551.1|AF027770 fxuD protein from Mycobacterium smegmatis (420 aa), FASTA scores: opt: 385, E(): 1.5e-16, (32.3% identity in 232 aa overlap). Also similar to AAB97475.1|U02617 DtxR/iron regulated lipoprotein precursor from Corynebacterium diphtheriae (355 aa); FECB_ECOLI|P15028 iron(III) dicitrate-binding periplasmic protein (300 aa), FASTA scores: opt: 191, E(): 2.3e-05, (26.5% identity in 196 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as fecB2.; fecB2; periplasmic IRON-transport lipoprotein	complement(316511..317503)	Mycobacterium tuberculosis H37Rv	886650
NP_214780.1	CDS	oplA	NC_000962.2	317525	321154	R	Rv0266c, (MTCY06A4.10c), len: 1209 aa. Probable oplA, 5-oxoprolinase (EC 3.5.2.9), highly similar to others or to hypothetical proteins e.g. AAK24340.1|AE005906 hydantoinase/oxoprolinase from Caulobacter crescentus (1196 aa); NP_103129.1|14022305|BAB48915.1|AP002997 5-oxoprolinase from Mesorhizobium loti (1210 aa); CAC48426.1|AL603642 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (1205 aa); S77037|slr0697|1006579|BAA10729.1|D6400 HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC 6803 (1252 aa), FASTA scores: opt: 2016, E(): 0, (51.4% identity in 1247 aa overlap); P97608|OPLA_RAT|T42756|11278797 5-OXOPROLINASE (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-OPASE) from Rattus norvegicus (1288 aa); etc. BELONGS TO THE OXOPROLINASE FAMILY.; 5-oxoprolinase	complement(317525..321154)	Mycobacterium tuberculosis H37Rv	886642
NP_214781.1	CDS	narU	NC_000962.2	321331	322722	D	Rv0267, (MTCY06A4.11), len: 463 aa. Probable narU, nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS), similar to other nitrite extrusion proteins e.g. NARU_ECOLI|P37758 nitrite extrusion protein 2 from Escherichia coli (462 aa), FASTA scores: opt: 630, E(): 4.4e-33, (38.9% identity in 463 aa overlap); and NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 607, E(): 1.3e-31, (42.0% identity in 457 aa overlap). Also similar to Rv0261c, Rv2329c, Rv1737c, and to MLCB22_25 from Mycobacterium leprae (517 aa), FASTA score: (35.1 identity in 459 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS.; integral membrane nitrite extrusion protein NarU	321331..322722	Mycobacterium tuberculosis H37Rv	886644
NP_214782.1	CDS	Rv0268c	NC_000962.2	322764	323273	R	Rv0268c, (MTCY06A4.12c), len: 169 aa. Hypothetical unknown protein.; hypothetical protein	complement(322764..323273)	Mycobacterium tuberculosis H37Rv	886647
NP_214783.1	CDS	Rv0269c	NC_000962.2	323338	324531	R	Rv0269c, (MTCY06A4.13c), len: 397 aa. Conserved hypothetical protein, highly similar to AL079355|SC4C6_19 hypothetical protein from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1019, E(): 0, (46.5% identity in 344 aa overlap), and similar to other proteins e.g. CAC49016.1|AL603644 putative ATP-dependent DNA ligase protein from Sinorhizobium meliloti (636 aa); O34398 YKOU PROTEIN from Bacillus subtilis (611 aa), FASTA score: (27.2% identity in 283 aa overlap). Also similar to proteins from Mycobacterium tuberculosis e.g. Rv3062, Rv3731 (both DNA ligases), and Rv0938, Rv3730c.; hypothetical protein	complement(323338..324531)	Mycobacterium tuberculosis H37Rv	886640
NP_214784.1	CDS	fadD2	NC_000962.2	324567	326249	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	324567..326249	Mycobacterium tuberculosis H37Rv	886637
NP_214785.1	CDS	fadE6	NC_000962.2	326266	328461	R	Rv0271c, (MTCY06A4.15c), len: 731 aa. Probable fadE6, acyl-CoA dehydrogenase (EC 1.3.99.-), with C-terminal half similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase (short-chain) from Homo sapiens (412 aa), FASTA scores: opt: 339, E(): 1.3e-13, (28.1% identity in 288 aa overlap).; acyl-CoA dehydrogenase FADE6	complement(326266..328461)	Mycobacterium tuberculosis H37Rv	886641
NP_214786.1	CDS	Rv0272c	NC_000962.2	328575	329708	R	Rv0272c, (MTCY06A4.16c), len: 377 aa. Hypothetical unknown protein.; hypothetical protein	complement(328575..329708)	Mycobacterium tuberculosis H37Rv	886635
NP_214787.1	CDS	Rv0273c	NC_000962.2	329705	330325	R	Rv0273c, (MTV035.01c), len: 206 aa (start uncertain). Possible transcriptional regulator, showing some similarity to hypothetical regulators from Mycobacterium tuberculosis e.g. P96222|Rv3855|MTCY01A6.13c (216 aa); O08377|Rv1534|MTCY07A7A.03 (225 aa), FASTA scores: opt: 123, E(): 3.2e-06, (28.5% identity in 172 aa overlap). TBparse score is 0.945.; transcriptional regulatory protein	complement(329705..330325)	Mycobacterium tuberculosis H37Rv	886633
NP_214788.1	CDS	Rv0274	NC_000962.2	330422	331003	D	Rv0274, (MTV035.02), len: 193 aa. Conserved hypothetical protein, highly similar to AAK25058.1|AE005973 conserved hypothetical protein from Caulobacter crescentus (174 aa). Shows also some similarity to others hypothetical proteins e.g. AJ002571|BSAJ2571_7 from Bacillus subtilis (316 aa), FASTA scores: opt: 138, E(): 0.033, (27.1% identity in 133 aa overlap). Previous hits with Q56415|M85195 FOSFOMYCIN-RESISTANCE PROTEIN from SERRATIA MARCESCENS (141 aa), FASTA scores: opt: 82, E(): 1.1e -08, (29.1% identity in 151 aa overlap). Contains PS00082 Extradiol ring-cleavage dioxygenases signature near C-terminus. TBparse score is 0.914.; hypothetical protein	330422..331003	Mycobacterium tuberculosis H37Rv	886631
YP_177706.1	CDS	Rv0275c	NC_000962.2	330933	331658	R	Rv0275c, (MTV035.03c), len: 241 aa. Possible transcriptional regulator, tetR family, similar to others e.g. Q9RJE7|SCF81.04c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (219 aa); Q9FBI8|SCP8.33c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (213 aa); Q9I2Q9|PA1836 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (193 aa); etc. Also shows some similarity with Rv0825c from Mycobacterium tuberculosis (213 aa), FASTA scores: opt: 230, E(): 2.7e-07, (32.6% identity in 190 aa overlap). SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS (M. tuberculosis regulatory protein family with many TetR orthologues).; TetR family transcriptional regulator	complement(330933..331658)	Mycobacterium tuberculosis H37Rv	886629
NP_214790.1	CDS	Rv0276	NC_000962.2	331748	332668	D	Rv0276, (MTV035.04), len: 306 aa. Conserved hypothetical protein, similar to Rv2237|Z70692|MTCY427.18 from Mycobacterium tuberculosis (296 aa), FASTA scores: opt: 874, E(): 0, (49.6% identity in 282 aa overlap).; hypothetical protein	331748..332668	Mycobacterium tuberculosis H37Rv	886627
NP_214791.1	CDS	Rv0277c	NC_000962.2	332708	333136	R	Rv0277c, (MTV035.05c), len: 152 aa. Conserved hypothetical protein, highly similar to Rv0749|H70824|2911023|CAA17516.1|AL021958 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (142 aa); and similar to several other hypothetical Mycobacterium tuberculosis proteins: Rv0277c, Rv2530c, etc.; hypothetical protein	complement(332708..333136)	Mycobacterium tuberculosis H37Rv	886625
YP_177707.1	CDS	PE_PGRS3	NC_000962.2	333437	336310	R	Rv0278c, (MTV035.06c), len: 957 aa. Member of the Mycobacterium tuberculosis PE family (see citation below), PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0, (67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1.; PE-PGRS family protein	complement(333437..336310)	Mycobacterium tuberculosis H37Rv	886623
YP_177708.1	CDS	PE_PGRS4	NC_000962.2	336560	339073	R	Rv0279c, (MTV035.07c), len: 837 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to many e.g. Z95890|MTCY28_25|Rv0278c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 2677, E(): 0, (64.5% identity in 926 aa overlap).; PE-PGRS family protein	complement(336560..339073)	Mycobacterium tuberculosis H37Rv	886621
YP_177709.1	CDS	PPE3	NC_000962.2	339364	340974	D	Rv0280, (MTV035.08), len: 536 aa. Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. Z80108|MTCY21B4_4|Rv0453 from Mycobacterium tuberculosis (539 aa), FASTA scores: opt: 1131, E(): 0, (51.7% identity in 540 aa overlap).; PPE family protein	339364..340974	Mycobacterium tuberculosis H37Rv	886619
NP_214795.1	CDS	Rv0281	NC_000962.2	340998	341906	D	Rv0281, (MTV035.09), len: 302 aa. Conserved hypothetical protein; member of Mycobacterium tuberculosis protein family that includes Rv0726c, Rv0731c, Rv3399, Rv1729c, etc. MTCY31_23 (325 aa), FASTA scores: opt: 1386, E(): 0, (69. 1% identity in 301 aa overlap). Contains possible N-terminal signal sequence.; hypothetical protein	340998..341906	Mycobacterium tuberculosis H37Rv	886618
NP_214796.1	CDS	Rv0282	NC_000962.2	342130	344025	D	Rv0282, (MTV035.10), len: 631 aa. Conserved hypothetical protein, similar to Y14967|MLCB628.18c hypothetical protein from Mycobacterium leprae (573 aa), FASTA scores: opt: 916, E(): 0, (38.7% identity in 568 aa overlap). Also similar to Mycobacterium tuberculosis proteins e.g. Z94121|MTY15F10.26 (619 aa), FASTA scores: opt: 743, E(): 0, (29.9% identity in 612 aa overlap). Member of CFXQ, CBXP family - 9 members in Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	342130..344025	Mycobacterium tuberculosis H37Rv	886613
NP_214797.1	CDS	Rv0283	NC_000962.2	344022	345638	D	Rv0283, (MTV035.11), len: 538 aa. Possible conserved membrane protein, similar to several hypothetical mycobacterial proteins e.g. Z94121|MTY15F10_16|Rv3895c from Mycobacterium tuberculosis (495 aa), FASTA scores: opt: 698, E(): 0, (37.6% identity in 492 aa overlap); Rv1782; Rv3450c; Rv3869; and Y14967|MLCB628_16|MLCB628.17c from Mycobacterium leprae (481 aa), FASTA scores: opt: 672, E(): 1.5e-31, (37.2% identity in 506 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	344022..345638	Mycobacterium tuberculosis H37Rv	886645
NP_214798.1	CDS	Rv0284	NC_000962.2	345635	349627	D	Rv0284, (MTV035.12), len: 1330 aa. Possible conserved membrane protein, similar to products of two adjacent Mycobacterium leprae genes, MLCB628.16c (744 aa) and MLCB628.15c (597 aa); and throughout its length to several large Mycobacterium tuberculosis proteins: Rv3447c, Rv3870, Rv1784, etc. Y14967|MLCB628_ 15 (744 aa), FASTA scores: opt: 942, E(): 0, (33.8% identity in 730 aa overlap); Y14967|MLCB628_14 (597 aa), FASTA scores: opt: 613, E(): 3.1e-30, (31.7% identity in 615 aa overlap); Z94121|MTY15F10_17 (1396 aa), FASTA scores: opt: 652, E(): 2.2e-32, (35.4% identity in 1321 aa overlap); Z95389|MTCY77_19 (1236 aa), FASTA scores: opt 652, E(): 2.2e-32, (35.4% identity in 1321 aa overlap). Contains three PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	345635..349627	Mycobacterium tuberculosis H37Rv	886611
YP_177710.1	CDS	PE5	NC_000962.2	349624	349932	D	Rv0285, (MTV035.13), len: 102 aa. Member of the Mycobacterium tuberculosis PE family (see Brennan & Delogu 2002), similar to others e.g. AL0212|MTV012_37 from Mycobacterium tuberculosis (105 aa), FASTA scores: opt: 497, E(): 2.6e-24, (80.4% identity in 102 aa overlap); Z80108|MTCY21B4.03 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 413, E(): 3.7e-19, (66.7% identity in 102 aa overlap); etc.; PE family protein	349624..349932	Mycobacterium tuberculosis H37Rv	886608
YP_177711.1	CDS	PPE4	NC_000962.2	349935	351476	D	Rv0286, (MTV035.14), len: 513 aa. Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 958, E(): 0, (43.5% identity in 522 aa overlap).; PPE family protein	349935..351476	Mycobacterium tuberculosis H37Rv	886607
NP_214801.1	CDS	esxG	NC_000962.2	351525	351818	D	Rv0287, (MTV035.15), len: 97 aa. esxG, ESAT-6 like protein. PE-family related protein; distant member of the Mycobacterium tuberculosis PE family, similar to Rv3020c|AL0212|MTV012.34 (97 aa), FASTA scores: opt: 564, E(): 0, (91.8% identity in 97 aa overlap). Contains probable helix-turn-helix motif at aa 14-35 (Score 144, +4.11 SD). SEEMS TO BELONG TO THE ESAT6 FAMILY (see Gey Van Pittius et al., 2001). Note that previously known as TB9.8.; TB9.8; hypothetical protein	351525..351818	Mycobacterium tuberculosis H37Rv	886604
NP_214802.1	CDS	esxH	NC_000962.2	351848	352138	D	Rv0288, (MT0301, MTV035.16), len: 96 aa. esxH, low molecular weight protein antigen 7 (10 kDa antigen) (CFP-7) (Protein TB10.4) (see citations below), ala-rich protein; member of mycobacterial protein family containing ESAT-6, very similar to MTV012_33 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 566, E(): 0, (84.4% identity in 96 aa overlap). Alternative start codon possible position 351878 (see Rosenkrands et al., 2000). BELONG TO THE ESAT6 FAMILY (see Skjot et al., 2000; 2002; Gey Van Pittius et al., 2001). Note that previously known as cfp7 (alternate gene name: TB10.4).; cfp7, TB10.4; low molecular weight protein antigen 7 ESXH (10 kDa antigen) (CFP-7) (protein TB10.4)	351848..352138	Mycobacterium tuberculosis H37Rv	886603
NP_214803.1	CDS	Rv0289	NC_000962.2	352149	353036	D	Rv0289, (MTV035.17), len: 295 aa. Conserved hypothetical protein, equivalent to CAC32061.1|AL583926 possible DNA-binding protein from Mycobacterium leprae (289 aa); and showing some similarity to Rv3866|G70656|CAB06238.1|Z94121|MTCY15F10.23 from Mycobacterium tuberculosis (276 aa), FASTA scores: opt: 149, E(): 0.0035, (27.7% identity in 289 aa overlap).; hypothetical protein	352149..353036	Mycobacterium tuberculosis H37Rv	886602
NP_214804.1	CDS	Rv0290	NC_000962.2	353083	354501	D	Rv0290, (MTV035.18), len: 472 aa. Probable conserved transmembrane protein, similar to several others in mycobacteria e.g. Z95389|MTCY77_20|Rv3887c from Mycobacterium tuberculosis (467 aa), FASTA scores: opt: 429, E(): 5.1e-19, (28. 6% identity in 479 aa overlap); Rv3877; Rv1795; Rv3448; and Y14967|MLCB628_9|MLCB628.10c from Mycobacterium leprae (480 aa), FASTA scores: opt: 269, E(): 3.1e-09, (26.0% identity in 503 aa overlap). TBparse score is 0.892.; transmembrane protein	353083..354501	Mycobacterium tuberculosis H37Rv	886599
NP_214805.1	CDS	mycP3	NC_000962.2	354498	355883	D	Rv0291, (MTV035.19), len: 461 aa. Probable mycP3, membrane-anchored serine protease (mycosin) (EC 3.4.21.-) (see Brown et al., 2000), similar to several others in mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from Mycobacterium tuberculosis (446 aa), FASTA scores: opt: 1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c; Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from Mycobacterium leprae (446 aa), FASTA scores: opt: 1159, E(): 0, (43.5 identity in 446 aa overlap). Has signal sequence and hydrophobic stretch at C-terminus, followed by short positively charged segment, that seems to act as a membrane anchor. Contains PS00137 Serine proteases, subtilase family, histidine active site signature. BELONGS TO PEPTIDASE FAMILY S8 (ALSO KNOWN AS THE SUBTILASE FAMILY), PYROLYSIN SUBFAMILY.; membrane-anchored mycosin	354498..355883	Mycobacterium tuberculosis H37Rv	886615
NP_214806.1	CDS	Rv0292	NC_000962.2	355880	356875	D	Rv0292, (MTV035.20), len: 331 aa. Probable conserved transmembrane protein (has two hydrophobic segments at N-terminal end), equivalent to CAC32058.1|AL583926 conserved membrane protein from Mycobacterium leprae (339 aa).; transmembrane protein	355880..356875	Mycobacterium tuberculosis H37Rv	886601
NP_214807.1	CDS	Rv0293c	NC_000962.2	356862	358064	R	Rv0293c, (MTV035.21c), len: 400 aa. Conserved hypothetical protein, similar in C-terminal part to Rv2627c|B70573|MTCY01A10.05|CAB08637.1|Z95387 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (413 aa), FASTA scores: opt: 394, E(): 2.1e-17, (31.1% identity in 299 aa overlap). TBparse score is 0.922.; hypothetical protein	complement(356862..358064)	Mycobacterium tuberculosis H37Rv	886594
NP_214808.1	CDS	tam	NC_000962.2	358171	358956	D	catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase	358171..358956	Mycobacterium tuberculosis H37Rv	886593
NP_214809.1	CDS	Rv0295c	NC_000962.2	358945	359748	R	Rv0295c, (MTV035.23c), len: 267 aa. Conserved hypothetical protein, showing weak similarity with CAC46877.1|AL591790 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (213 aa); and NP_104818.1|14023999|BAB50604.1|AP00300 Protein with weak similarity to NodH from Mesorhizobium loti (257 aa). TBparse score is 0.915.; hypothetical protein	complement(358945..359748)	Mycobacterium tuberculosis H37Rv	886596
YP_177712.1	CDS	Rv0296c	NC_000962.2	359758	361155	R	Rv0296c, (MTCY63.01c, MTV035.24c), len: 465 aa. Probable sulfatase, possibly an aryl-/steryl-sulfatase (EC 3.1.6.-) or a sulfamidase (sulfohydrolase) (sulphamidase) (EC 3.10.1.-). Similar to various hydrolases e.g. AAG41945.1|AF304053_1|AF304053 heparan N-sulfatase from Mus musculus (502 aa); NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827 N-sulfoglucosamine sulfohydrolase (sulfamidase) (sulphamidase) from Mus musculus (502 aa); AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase from Canis familiaris (507 aa); P08842|STS_HUMAN|1360652 STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL-SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC) from Homo sapiens (583 aa); ARSB_FELCA|P33727 arylsulfatase B precursor (EC 3.1.6.1) (535 aa), FASTA scores: opt: 231, E(): 1.7e-08, (30.3% identity in 261 aa overlap). Also similarity with 4 others sulfatases in Mycobacterium tuberculosis. Contains sulfatases signature 1 (PS00523). Note that previously known as atsG.; atsG; sulfatase	complement(359758..361155)	Mycobacterium tuberculosis H37Rv	886600
YP_177713.1	CDS	PE_PGRS5	NC_000962.2	361334	363109	D	Rv0297, (MTCY63.02), len: 591 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to others e.g. Y03A_MYCTU|Q10637 from Mycobacterium tuberculosis (603 aa), FASTA scores: opt: 1884, E(): 0, (53.7% identity in 635 aa overlap). TBparse score is 0.850.; PE-PGRS family protein	361334..363109	Mycobacterium tuberculosis H37Rv	885981
NP_214812.1	CDS	Rv0298	NC_000962.2	363252	363479	D	Rv0298, (MTCY63.03), len: 75 aa. Hypothetical unknown protein. TBparse score is 0.891.; hypothetical protein	363252..363479	Mycobacterium tuberculosis H37Rv	886590
NP_214813.1	CDS	Rv0299	NC_000962.2	363476	363778	D	Rv0299, (MTCY63.04), len: 100 aa. Hypothetical unknown protein. Equivalent to AAK44536.1 from Mycobacterium tuberculosis strain CDC1551 (49 aa) but longer 51 aa.; hypothetical protein	363476..363778	Mycobacterium tuberculosis H37Rv	886598
NP_214814.1	CDS	Rv0300	NC_000962.2	363826	364047	D	Rv0300, (MTCY63.05), len: 73 aa. Conserved hypothetical protein, similar to Rv1721c|MTCY04C12.06c|Z81360|MTCY4C12_4 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (75 aa), FASTA scores: opt: 84, E(): 8.3, (39.5% identity in 38 aa overlap).; hypothetical protein	363826..364047	Mycobacterium tuberculosis H37Rv	886588
NP_214815.1	CDS	Rv0301	NC_000962.2	364044	364469	D	Rv0301, (MTCY63.06), len: 141 aa. Conserved hypothetical protein, similar to other hypothetical Mycobacterium tuberculosis proteins e.g. Rv2757c, Rv0229c, Rv2546, etc.; hypothetical protein	364044..364469	Mycobacterium tuberculosis H37Rv	886586
NP_214816.1	CDS	Rv0302	NC_000962.2	364605	365237	D	Rv0302, (MTCY63.07), len: 210 aa. Probable transcription regulatory protein, TetR family (see citation below), with its N-terminus similar to N-terminus of several repressors and regulatory proteins of TetR/AcrR family e.g. ACRR_ECOLI|P34000 potential acraB operon repressor from Escherichia coli (215 aa), FASTA scores: opt: 172, E(): 3.1e-05, (22.7% identity in 194 aa overlap). Also similar in N-terminus to N-terminus of MTCY07A7.24 hypothetical regulator from Mycobacterium tuberculosis FASTA score: (38.7% identity in 62 aa overlap). Contains probable helix-turn helix motif from aa 35-56 (Score 1728, +5.07 SD). TBparse score is 0.896.; TetR/ACRR family transcriptional regulator	364605..365237	Mycobacterium tuberculosis H37Rv	886584
NP_214817.1	CDS	Rv0303	NC_000962.2	365234	366142	D	Rv0303, (MTCY63.08), len: 302 aa. Possible dehydrogenase/reductase (EC 1.-.-.-), similar to various NADPH dehydrogenases and other NADPH oxidoreductases e.g. O48741|PORC_ARATH|7488284|T00897 PROTOCHLOROPHYLLIDE REDUCTASE C CHLOROPLAST PRECURSOR (EC 1.3.1.33) (NADPH-PROTOCHLOROPHYLLIDE OXIDOREDUCTASE C) from Arabidopsis thaliana (401 aa); Q42850 NADPH DEHYDROGENASE (EC 1.6.99. 1) (395 aa), FASTA scores: opt: 347, E(): 3.8e-16, (35.4% identity in 319 aa overlap). TBparse score is 0.905.; dehydrogenase/reductase	365234..366142	Mycobacterium tuberculosis H37Rv	886581
YP_177714.1	CDS	PPE5	NC_000962.2	366150	372764	R	Rv0304c, (MTCY63.9c), len: 2204 aa. Member of the Mycobacterium tuberculosis PE family (PPE, MPTR), similar to others e.g. Z95324|MTY13E10_16 from Mycobacterium tuberculosis (1443 aa), FASTA scores: E(): 0, (50.6% identity in 1403 aa overlap); Y04H_MYCTU|Q10778 from Mycobacterium tuberculosis (734 aa), FASTA scores: opt: 989, E(): 0, (42.3% identity in 522 aa overlap).; PPE family protein	complement(366150..372764)	Mycobacterium tuberculosis H37Rv	886592
YP_177715.1	CDS	PPE6	NC_000962.2	372820	375711	R	Rv0305c, (MTCY63.10c), len: 963 aa. Member of the Mycobacterium tuberculosis PE family (PPE, MPTR), similar to others e.g. Y04H_MYCTU|Q10778 from Mycobacterium tuberculosis (734 aa), FASTA scores: opt: 1340, E(): 0, (40.9% identity in 815 aa overlap).; PPE family protein	complement(372820..375711)	Mycobacterium tuberculosis H37Rv	885978
NP_214820.1	CDS	Rv0306	NC_000962.2	375914	376585	D	Rv0306, (MTCY63.11), len: 223 aa. Putative oxidoreductase (EC 1.-.-.-), highly similar to H83485|9947208|AAG04663.1|AE004557_4|AE004557 conserved hypothetical protein from Pseudomonas aeruginosa strain PAO1 (218 aa); and to other putative oxidoreductases e.g. middle part of CAB76073.1|AL157953 putative nitroreductase from Streptomyces coelicolor (1212 aa); Q52685|BLUB protein involved in cobalamin (vitamin B12) synthesis from Rhodobacter capsulatus (206 aa), FASTA scores: opt: 318, E(): 2e-15, (35.6% identity in 191 aa overlap). TBparse score is 0.900.; putative oxidoreductase	375914..376585	Mycobacterium tuberculosis H37Rv	886577
NP_214821.1	CDS	Rv0307c	NC_000962.2	376573	377055	R	Rv0307c, (MTCY63.12c), len: 160 aa. Hypothetical unknown protein. TBparse score is 0.901.; hypothetical protein	complement(376573..377055)	Mycobacterium tuberculosis H37Rv	886580
NP_214822.1	CDS	Rv0308	NC_000962.2	377113	377829	D	Rv0308, (MTCY63.13), len: 238 aa. Probable conserved integral membrane protein, with C-terminus highly similar to C-terminus of other integral membrane proteins or phosphatases e.g. AAK25788.1|AF336822_1|13430250|AAK25789.1|AF336823_1 putative phosphatase from Streptococcus pyogenes (201 aa); Q06074 HYPOTHETICAL 24.9 kDa PROTEIN (216 aa), FASTA scores: opt: 209, E(): 2e-07, (27.9% identity in 140 aa overlap). Could be a phosphatase. TBparse score is 0.961.; integral membrane protein	377113..377829	Mycobacterium tuberculosis H37Rv	886583
NP_214823.1	CDS	Rv0309	NC_000962.2	377931	378587	D	Rv0309, (MTCY63.14), len: 218 aa. Possible conserved exported protein (has putative N-terminal signal sequence), equivalent to AC32053.1|AL583926 putative secreted protein from Mycobacterium leprae (218 aa). Also similar to others e.g. AB76092.1|AL157956 putative secreted protein from Streptomyces coelicolor (238 aa).; hypothetical protein	377931..378587	Mycobacterium tuberculosis H37Rv	886574
NP_214824.1	CDS	Rv0310c	NC_000962.2	378657	379148	R	Rv0310c, (MTCY63.15c), len: 163 aa. Conserved hypothetical protein, similar to some bile acid dehydratases e.g. P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 BILE ACID-INDUCIBLE OPERON PROTEIN E from Eubacterium sp (166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8% identity in 134 aa overlap); AAF22847.1|AF210152_4 bile acid 7a-dehydratase from Clostridium sp. (168 aa). TBparse score is 0.863.; hypothetical protein	complement(378657..379148)	Mycobacterium tuberculosis H37Rv	886570
NP_214825.1	CDS	Rv0311	NC_000962.2	379172	380401	D	Rv0311, (MTCY63.16), len: 409 aa. Hypothetical unknown protein. Contains PS00881 Protein splicing signature. TBparse score is 0.903.; hypothetical protein	379172..380401	Mycobacterium tuberculosis H37Rv	886579
NP_214826.1	CDS	Rv0312	NC_000962.2	380556	382418	D	Rv0312, (MTCY63.17), len: 620 aa. Conserved hypothetical protein with highly Pro-, Thr-rich C-terminus. Similar to Pro-,Thr-rich region in Rv2264c|AL021925|MTV022_14 from Mycobacterium tuberculosis (592 aa), FASTA scores: opt: 1075, E(): 0, (38.9% identity in 627 aa overlap). Also some similarity with Rv0350|dnaK from Mycobacterium tuberculosis. Possibly membrane protein; has hydrophobic stetch in its middle part.; hypothetical protein	380556..382418	Mycobacterium tuberculosis H37Rv	886566
NP_214827.1	CDS	Rv0313	NC_000962.2	382490	382876	D	Rv0313, (MTCY63.18), len: 128 aa. Conserved hypothetical protein, equivalent only to CAC32049.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (130 aa). TBparse score is 0.877.; hypothetical protein	382490..382876	Mycobacterium tuberculosis H37Rv	886572
NP_214828.1	CDS	Rv0314c	NC_000962.2	382879	383541	R	Rv0314c, (MTCY63.19c), len: 220 aa. Possible conserved membrane protein, with hydrophobic stretch from residues 75-100. Similar in C-terminal part to Mycobacterium tuberculosis proteins Rv0679c and Rv0680c.; hypothetical protein	complement(382879..383541)	Mycobacterium tuberculosis H37Rv	886564
NP_214829.1	CDS	Rv0315	NC_000962.2	383602	384486	D	Rv0315, (MTCY63.20), len: 294 aa. Possible beta-1,3-glucanase precursor (EC 3.2.1.-) (has hydrophobic stretch in its N-terminal part), similar to others e.g. Q51333|AAC44371.1 BETA-1,3-GLUCANASE II A from Oerskovia xanthineolytica (306 aa), FASTA scores: opt: 76, E(): 3e-14, (34.1% identity in 302 aa overlap); and AAC38290.1|AF052745 beta-1,3-glucanase II from Oerskovia xanthineolytica (435 aa). Contains glycosyl hydrolases family 16 active site signature (PS01034). TBparse score is 0.908.; beta-1,3-glucanase precursor	383602..384486	Mycobacterium tuberculosis H37Rv	886563
NP_214830.1	CDS	Rv0316	NC_000962.2	384535	385149	D	Rv0316, (MTCY63.21), len: 204 aa. Possible muconolactone isomerase (EC 5.3.3.-), showing weak similarity with some muconolactone isomerases e.g. O33947|CTC1_ACILW MUCONOLACTONE DELTA-ISOMERASE 1 (MIASE 1)(96 aa), FASTA scores: opt: 179, E(): 3.9e-05, (32.6% identity in 92 aa overlap). TBparse score is 0.882.; muconolactone isomerase	384535..385149	Mycobacterium tuberculosis H37Rv	886560
NP_214831.1	CDS	glpQ2	NC_000962.2	385173	385943	R	Rv0317c, (MTCY63.22c), len: 256 aa (start uncertain, chosen by homology). Possible glpQ2, glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46), similar to others e.g. E75317|6459876|AAF11631.1|AE002044_4 glycerophosphoryl diester phosphodiesterase from Deinococcus radiodurans (285 aa); P10908|UGPQ_ECOLI from Escherichia coli (247 aa), FASTA scores: opt: 220, E(): 5.2e-07, (28.0% identity in 250 aa overlap). Also similar to MTCY01A6.27 from Mycobacterium tuberculosis FASTA score: (27.5% identity in 247 aa overlap). TBparse score is 0.906.; glycerophosphoryl diester phosphodiesterase	complement(385173..385943)	Mycobacterium tuberculosis H37Rv	886559
YP_177716.1	CDS	Rv0318c	NC_000962.2	386305	387099	R	Rv0318c, (MTCY63.23c), len: 258 aa. Probable conserved integral membrane protein, with some similarity to C-terminus of GUFA_MYXXA|Q06916 (254 aa), FASTA scores: opt: 157, E (): 0.0032, (28.3% identity in 198 aa overlap). Also similar to O26573 CONSERVED PROTEIN from Methanobacterium thermoauto (259 aa), FASTA scores: opt: 173, E(): 5.2e-05, (32.7% identity in 214 aa overlap).; integral membrane protein	complement(386305..387099)	Mycobacterium tuberculosis H37Rv	886576
NP_214833.1	CDS	pcp	NC_000962.2	387148	387816	D	catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase	387148..387816	Mycobacterium tuberculosis H37Rv	886555
NP_214834.1	CDS	Rv0320	NC_000962.2	387888	388550	D	Rv0320, (MTCY63.25), len: 220 aa. Possible conserved exported protein, similar to some hypothetical proteins and to the middle part of a peptidase: NP_066789.1|10657900|AAG21739.1|AF116907 putative peptidase from Rhodococcus equi (546 aa). Also similar to Rv1728c|MTCY04C12.13c from Mycobacterium tuberculosis (256 aa), FASTA scores: opt: 497, E(): 1.2e-26, (41.8% identity in 225 aa overlap). TBparse score is 0.943.; hypothetical protein	387888..388550	Mycobacterium tuberculosis H37Rv	886553
NP_214835.1	CDS	dcd	NC_000962.2	388582	389154	D	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase	388582..389154	Mycobacterium tuberculosis H37Rv	886552
NP_214836.1	CDS	udgA	NC_000962.2	389260	390591	D	Rv0322, (MTCY63.27), len: 443 aa. Probable udg (alternate gene name: rkpK), UDP-glucose 6-dehydrogenase (EC 1.1.1.22), highly similar to others e.g. CAC44517.1|AL596138 putative UDP-glucose 6-dehydrogenase from Streptomyces coelicolor (447 aa); Q56812 UDP-GLUCOSE DEHYDROGENASE from Xanthomonas campestris (445 aa), FASTA scores: opt: 713, E(): 0, (41.9% identity in 351 aa overlap); etc. Also similar to several GDP-mannose 6-dehydrogenase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UDP-GLUCOSE/GDP-MANNOSE DEHYDROGENASES FAMILY. TBparse score is 0.905.; rkpK; UDP-glucose 6-dehydrogenase UdgA	389260..390591	Mycobacterium tuberculosis H37Rv	886550
NP_214837.1	CDS	Rv0323c	NC_000962.2	390580	391251	R	Rv0323c, (MTCY63.28c), len: 223 aa. Conserved hypothetical protein, similar to others e.g. YPJG_BACSU|P42981 hypothetical 24.8 kDa protein from Bacillus subtilis (224 aa), FASTA scores: opt: 182, E(): 1.3e-05, (27.5% identity in 211 aa overlap). Also some similarity to MLU15183_8 from Mycobacterium tuberculosis FASTA score: (32.0% identity in 147 aa overlap). TBparse score is 0.932.; hypothetical protein	complement(390580..391251)	Mycobacterium tuberculosis H37Rv	886557
NP_214838.1	CDS	Rv0324	NC_000962.2	391352	392032	D	Rv0324, (MTCY63.29), len: 226 aa. Possible transcriptional regulator, arsR family, with its N-terminus similar to the N-terminus of other DNA-binding proteins e.g. P30346|MERR_STRLI probable mercury resistance operon from Streptomyces lividans (125 aa), FASTA scores: opt: 154, E(): 0.002, (32.2% identity in 90 aa overlap)), and its C-terminal part similar to hypothetical bacterial proteins e.g. P54510|YQHL_BACSU hypothetical 14.6 kDa protein from Bacillus subtilis (126 aa), FASTA scores: opt: 159, E(): 0.00097, (35.5% identity in 76 aa overlap)). Most similar to AJ005575|SPE005575_2 ORF1 required for antibiotic production from Streptomyces peucetius (226 aa), FASTA scores: opt: 816, E(): 0, (60.7% identity in 211 aa overlap). Also similar in C-terminus to MTCY164.26 molybdopterin biosynthesis moeb protein from Mycobacterium tuberculosis FASTA score: (36.8% identity in 114 aa overlap).; ArsR family transcriptional regulator	391352..392032	Mycobacterium tuberculosis H37Rv	886548
NP_214839.1	CDS	Rv0325	NC_000962.2	392039	392263	D	Rv0325, (MTCY63.30), len: 74 aa. Hypothetical unknown protein. TBparse score is 0.915.; hypothetical protein	392039..392263	Mycobacterium tuberculosis H37Rv	886546
NP_214840.1	CDS	Rv0326	NC_000962.2	392273	392728	D	Rv0326, (MTCY63.31), len: 151 aa. Hypothetical unknown protein. TBparse score is 0.929.; hypothetical protein	392273..392728	Mycobacterium tuberculosis H37Rv	886544
NP_214841.1	CDS	cyp135A1	NC_000962.2	392696	394045	R	Rv0327c, (MT0342, MTCY63.32c), len: 449 aa. Possible cyp135A1, cytochrome P450 (EC 1.14.-.-), similar to cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. FQ12609 PUTATIVE P450 MONOOXYGENASE (EC 1.14.14.1) (506 aa), FASTA scores: opt: 276, E() : 1.7e-11, (27.9% identity in 433 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. MTV039.06|Rv0568 PUTATIVE CYTOCHROME P450 (472 aa); MTCI5.10 cytochrome p450 FASTA score: (30.4% identity in 434 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY. Alternative start possible at 33706 but no RBS.; cytochrome P450 135A1	complement(392696..394045)	Mycobacterium tuberculosis H37Rv	886538
NP_214842.1	CDS	Rv0328	NC_000962.2	394111	394713	D	Rv0328, (MTCY63.33), len: 200 aa. Possible transcription regulator, tetR/acrR family, similar in part to various hypothetical transcriptional regulators e.g. T36696|4726006|CAB41735.1|AL049731 probable regulatory protein from Streptomyces coelicolor (197 aa). Also some similarity with YX44_MYCTU|Q10829 hypothetical transcriptional regulator from Mycobacterium tuberculosis (195 aa), FASTA scores: opt: 154, E(): 0.00061, (26.7% identity in 202 aa overlap). Contains probable helix-turn helix motif from aa 27-48 (Score 1408, +3.98 SD). SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.910.; TetR/AcrR family transcriptional regulator	394111..394713	Mycobacterium tuberculosis H37Rv	886542
NP_214843.1	CDS	Rv0329c	NC_000962.2	394694	395320	R	Rv0329c, (MTCY63.34c), len: 208 aa. Conserved hypothetical protein, showing some similarity with others hypothetical proteins and methyltransferases e.g. MitM|AF127374_14 methyltransferase from Streptomyces lavendulae (283 aa), FASTA scores: opt: 242, E(): 1.8e-08, (37.2% identity in 145 aa overlap); Q48938 from Methanosarcina barkeri (262 aa), FASTA scores: opt: 194, E(): 3.6e-06, (31.1% identity in 119 aa overlap). TBparse score is 0.923.; hypothetical protein	complement(394694..395320)	Mycobacterium tuberculosis H37Rv	886536
NP_214844.1	CDS	Rv0330c	NC_000962.2	395347	396087	R	Rv0330c, (MTCY63.35c), len: 246 aa. Hypothetical unknown protein. TBparse score is 0.898.; hypothetical protein	complement(395347..396087)	Mycobacterium tuberculosis H37Rv	886540
NP_214845.1	CDS	Rv0331	NC_000962.2	396201	397367	D	Rv0331, (MTCY63.36), len: 388 aa. Possible dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases e.g. NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein reductase from Mesorhizobium loti (377 aa); NP_147681.1 predicted NAD(FAD)-dependent dehydrogenase from Aeropyrum pernix (381 aa); DHSU_CHRVI|Q06530 sulfide dehydrogenase (431 aa), FASTA scores: opt: 347, E(): 6.8e-15, (25.6% identity in 348 aa overlap). TBparse score is 0.906.; dehydrogenase/reductase	396201..397367	Mycobacterium tuberculosis H37Rv	886534
NP_214846.1	CDS	Rv0332	NC_000962.2	397442	398227	D	Rv0332, (MTCY63.37), len: 261 aa. Conserved hypothetical protein, similar to several conserved hypothetical proteins from Streptomyces coelicolor e.g. SC6A9.18c|AL031035|SC6A9_18|T35449 hypothetical protein (266 aa), FASTA scores: opt: 508, E(): 5.7e-27, (36.7% identity in 251 aa overlap). TBparse score is 0.905.; hypothetical protein	397442..398227	Mycobacterium tuberculosis H37Rv	886532
NP_214847.1	CDS	Rv0333	NC_000962.2	398254	398628	D	Rv0333, (MTCY63.38), len: 124 aa. Hypothetical unknown protein.; hypothetical protein	398254..398628	Mycobacterium tuberculosis H37Rv	886528
NP_214848.1	CDS	rmlA	NC_000962.2	398658	399524	D	Rv0334, (MTCY279.01), len: 288 aa. rmlA (alternate gene name: rfbA), alpha-D-glucose-1-phosphate thymidylyl-transferase (EC 2.7.7.24) (see citations below), equivalent to CAC32020.1|AL583925 glucose-1-phosphate thymidyltransferase from Mycobacterium leprae (288 aa). Also highly similar to others e.g. AAG29804.1|AF235050 glucose-1-phosphate thymidylyltransferase from Streptomyces rishiriensis (296 aa); RBA1_ECOLI|P37744 glucose-1-phosphate thymidylyltransferase from Escherichia coli strain K12 (293 aa), FASTA scores: opt: 1199, E(): 0, (62.0% identity in 284 aa overlap). BELONGS TO THE GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE FAMILY.; rfbA; alpha-D-glucose-1-phosphate thymidylyltransferase RmlA	398658..399524	Mycobacterium tuberculosis H37Rv	886568
YP_177717.1	CDS	PE6	NC_000962.2	399535	400050	R	Rv0335c, (MTCY279.02c), len: 171 aa. Member of the Mycobacterium tuberculosis PE family (see Brennan & Delogu 2002); contains short region of similarity to part of the unique N-terminus of the Mycobacterium tuberculosis PGRS family of Glycine-rich proteins e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt: 219, E(): 1.1e-08, (51.5% identity in 66 aa overlap).; PE family protein	complement(399535..400050)	Mycobacterium tuberculosis H37Rv	886527
NP_214850.1	CDS	Rv0336	NC_000962.2	400192	401703	D	Rv0336, (MTCY279.03), len: 503 aa. Part of Mycobacterium tuberculosis 13E12 repeat family; almost identical to Rv0515|MTCY20G10.05 hypothetical protein from Mycobacterium tuberculosis FASTA scores: (99.8% identity in 503 aa overlap), possibly due to a recent gene duplication. Also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1148c, Rv1945, etc.; 13E12 repeat family protein	400192..401703	Mycobacterium tuberculosis H37Rv	886524
NP_214851.1	CDS	aspC	NC_000962.2	401873	403162	R	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT	complement(401873..403162)	Mycobacterium tuberculosis H37Rv	886522
NP_214852.1	CDS	Rv0338c	NC_000962.2	403193	405841	R	Rv0338c, (MTCY279.05c), len: 882 aa. Probable iron-sulphur-binding reductase (EC 1.-.-.-), possibly membrane-bound, equivalent to CAC32018.1|AL583925 probable iron-sulphur-binding reductase from Mycobacterium leprae (880 aa). Also highly similar to others e.g. T36608|5019323|CAB44376.1|AL078610 probable iron-sulfur-binding reductase from Streptomyces coelicolor (760 aa), FASTA scores: opt: 1658, E(): 0, (49.9% identity in 772 aa overlap); BAB07521.1|AP001520 iron-sulphur-binding reductase from Bacillus halodurans (700 aa). Contains PS00070 Aldehyde dehydrogenases cysteine active site and two of PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. First of several possible start sites chosen.; iron-sulfur-binding reductase	complement(403193..405841)	Mycobacterium tuberculosis H37Rv	886520
NP_214853.1	CDS	Rv0339c	NC_000962.2	405950	408448	R	Rv0339c, (MTCY279.06c), len: 832 aa. Possible transcriptional regulator, showing very weak similarity with parts of others. Contains PS00017 ATP/GTP-binding site motif A (P-loop ); and probable helix-turn helix motif from aa 778-799 (Score 1041, +2.73 SD).; transcriptional regulatory protein	complement(405950..408448)	Mycobacterium tuberculosis H37Rv	886516
NP_214854.1	CDS	Rv0340	NC_000962.2	408634	409173	D	Rv0340, (MTCY279.07), len: 179 aa. Conserved hypothetical protein; MEME-MAST analysis shows similarity to product of downstream gene, Rv0341|iniB.; hypothetical protein	408634..409173	Mycobacterium tuberculosis H37Rv	886514
NP_214855.1	CDS	iniB	NC_000962.2	409362	410801	D	Rv0341, iniB, (MTCY13E10.01), len: 479 aa. iniB, isoniazid-inducible gene, (see citations below). Protein very Gly-, Ala-rich, similar to cell wall proteins e.g. P27483|GRP_ARATH GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN from A.thaliana (338 aa), FASTA scores: opt: 532, E(): 5.2e-13, (39.3% identity in 321 aa overlap). MEME-MAST analysis shows similarity to product of upstream gene, Rv0340.; isoniazid inductible gene protein INIB	409362..410801	Mycobacterium tuberculosis H37Rv	886518
NP_214856.1	CDS	iniA	NC_000962.2	410838	412760	D	Rv0342, iniA, (MTCY13E10.02), len: 640 aa. iniA, isoniazid-inducible gene, (see citations below). Shows slight similarity to some hypothetical bacterial proteins e.g. P40983|YOR6_THER hypothetical protein (402 aa), FASTA scores: opt: 242, E(): 1.4e-07, (22.3% identity in 349 aa overlap). Also some similarity to downstream ORF Rv0343|iniC. Possible transmembrane stretch around residue 490. Alternative translational start at 410824. Contains a phosphopantetheine attachment site motif suggestive of an acyl carrier protein. Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid.; isoniazid inductible gene protein INIA	410838..412760	Mycobacterium tuberculosis H37Rv	886510
NP_214857.1	CDS	iniC	NC_000962.2	412757	414238	D	Rv0343, (MTCY13E10.03), len: 493 aa. iniC, isoniazid-inducible gene, (see citations below). Shows slight similarity to P40983|YOR6_THER8 hypothetical protein (402 aa), FASTA scores: opt: 196, E(): 2.6e-05, (25.9% identity in 228 aa overlap). Also some similarity to upstream ORF Rv0342|iniA. Contains (PS00017) ATP/GTP-binding site motif A (P-loop). Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid.; isoniazid inductible gene protein INIC	412757..414238	Mycobacterium tuberculosis H37Rv	886508
NP_214858.1	CDS	lpqJ	NC_000962.2	414381	414941	R	Rv0344c, (MTCY13E10.04c), len: 186 aa. Probable lipoprotein, without homology. Has an appropriately positioned prokaryotic lipoprotein signature (PS00013).; lipoprotein LpqJ	complement(414381..414941)	Mycobacterium tuberculosis H37Rv	886512
NP_214859.1	CDS	Rv0345	NC_000962.2	415050	415460	D	Rv0345, (MTCY13E10.05), len: 136 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. AL13282 4|SCAH10_9 hypothetical protein from Streptomyces coelicolor (207 aa), FASTA scores: opt: 188, E(): 1.5e-05, (41.0% identity in 117 aa overlap).; hypothetical protein	415050..415460	Mycobacterium tuberculosis H37Rv	886505
YP_177718.1	CDS	ansP2	NC_000962.2	415502	416965	R	Rv0346c, (MTCY13E10.06c), len: 487 aa. Possible ansP2, L-asparagine permease, integral membrane protein belonging to family containing many amino acid permeases, highly similar to G467030|B2126_F2_85|NP_301937.1|NC_002677 probable L-asparagine permease from Mycobacterium leprae (498 aa); and NP_301938.1|NC_002677 probable L-asparagine permease from Mycobacterium leprae (505 aa). Also highly similar to others e.g. P77610|ANSP_ECOLI L-ASPARAGINE PERMEASE from Escherichia coli strain K-12 (499 aa). Also highly similar to ANSP1|Rv2127|MT2186|MTCY261_22|O33261 PROBABLE L-ASPARAGINE PERMEASE from Mycobacterium tuberculosis (489 aa), FASTA score: (72.1% identity in 473 aa overlap). And shows some similarity to MTCY3G12.14 from Mycobacterium tuberculosis. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY). Note that previously known as aroP2.; aroP2; L-asparagine ABC transporter permease	complement(415502..416965)	Mycobacterium tuberculosis H37Rv	886530
NP_214861.1	CDS	Rv0347	NC_000962.2	417304	418290	D	Rv0347, (MTCY13E10.07), len: 328 aa (alternative start possible). Probable conserved membrane protein, similar to Rv0831c|AL022004|MTV043_23 from Mycobacterium tuberculosis (271 aa), FASTA scores: E(): 9.6e-21, (33.1% identity in 266 aa overlap).; hypothetical protein	417304..418290	Mycobacterium tuberculosis H37Rv	886501
NP_214862.1	CDS	Rv0348	NC_000962.2	418293	418946	D	Rv0348, (MTCY13E10.08), len: 217 aa. Possible transcriptional regulator, showing some similarity to O53334|RV3188|MTV014.32 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (115 aa), FASTA score: (30.0% identity in 100 aa overlap). Contains probable helix-turn helix motif from aa 89-110 (Score 1407, +3.98 SD).; transcriptional regulatory protein	418293..418946	Mycobacterium tuberculosis H37Rv	886500
NP_214863.1	CDS	Rv0349	NC_000962.2	418949	419608	D	Rv0349, (MTCY13E10.09), len: 219 aa. Hypothetical unknown protein.; hypothetical protein	418949..419608	Mycobacterium tuberculosis H37Rv	886506
NP_214864.1	CDS	dnaK	NC_000962.2	419835	421712	D	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK	419835..421712	Mycobacterium tuberculosis H37Rv	885946
NP_214865.1	CDS	grpE	NC_000962.2	421709	422416	D	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE	421709..422416	Mycobacterium tuberculosis H37Rv	886497
YP_177719.1	CDS	dnaJ1	NC_000962.2	422452	423639	D	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ	422452..423639	Mycobacterium tuberculosis H37Rv	886495
NP_214867.1	CDS	hspR	NC_000962.2	423639	424019	D	Rv0353, (MTCY13E10.13), len: 126 aa. Probable hspR, heat shock regulatory protein (see Stewart et al., 2001), merR family, highly similar to others e.g. HspR|P40183 heat shock regulatory protein from Streptomyces coelicolor (151 aa), FASTA scores: E(): 4.9e-22, (55.7% identity in 140 aa overlap), that binds to three inverted repeats (IR1-IR3) in the promoter region of the dnaK operon. Has possible coiled coil region in C-terminal half. BELONGS TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS.; HEAT shock protein transcriptional repressor HspR	423639..424019	Mycobacterium tuberculosis H37Rv	885929
YP_177720.1	CDS	PPE7	NC_000962.2	424269	424694	R	Rv0354c, (MTCY13E10.14c), len: 141 aa. Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. MTCY63_9 from Mycobacterium tuberculosis (2411 aa), FASTA scores: E(): 3.6e-11, (47.6% identity in 103 aa overlap). Possible continuation of ORF upstream, but no sequence error apparent.; PPE family protein	complement(424269..424694)	Mycobacterium tuberculosis H37Rv	886498
YP_177721.1	CDS	PPE8	NC_000962.2	424777	434679	R	Rv0355c, (MTCY13E10.15c, MTCY13E10.16c, MTCY13E10.17c) len: 3300 aa. Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL009198|MTV004_5 from Mycobacterium tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0, (40.9% identity in 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity in 3531 aa overlap); etc. Gene contains large number of clustered Major Polymorphic Tandem Repeats (MPTR). Related to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; MTCY48.17, E(): 0; MTCY98.0034c, E(): 0; MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0; MTCY31.06c, E(): 5.6e-17; MTCY359.33, E(): 2.3e-16.; PPE family protein	complement(424777..434679)	Mycobacterium tuberculosis H37Rv	886491
NP_214870.1	CDS	Rv0356c	NC_000962.2	434830	435474	R	Rv0356c, (MTCY13E10.18c), len: 214 aa. Conserved hypothetical protein, equivalent to AL023514|MLCB4_12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (218 aa), FASTA scores: opt: 1067, E(): 0, (73.4% identity in 214 aa overlap).; hypothetical protein	complement(434830..435474)	Mycobacterium tuberculosis H37Rv	886490
NP_214871.1	CDS	purA	NC_000962.2	435471	436769	R	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase	complement(435471..436769)	Mycobacterium tuberculosis H37Rv	886484
NP_214872.1	CDS	Rv0358	NC_000962.2	436860	437507	D	Rv0358, (MTCY13E10.20), len: 215 aa. Conserved hypothetical protein, highly similar to ML0281|AL023514|MLCB4_14 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (229 aa), FASTA scores: opt: 852, E(): 0, (62.9% identity in 229 aa overlap).; hypothetical protein	436860..437507	Mycobacterium tuberculosis H37Rv	886493
NP_214873.1	CDS	Rv0359	NC_000962.2	437518	438297	D	Rv0359, (MTCY13E10.21), len: 259 aa. Probable conserved integral membrane protein, highly similar to hypothetical or other membrane proteins e.g. AL133220|SCC75A_6|T50569 probable membrane protein from Streptomyces coelicolor (265 aa), FASTA scores: opt: 642, E(): 0, (43.1% identity in 248 aa overlap); P70995 HYPOTHETICAL 24.7 kDa PROTEIN from Bacillus subtilis (219 aa), FASTA scores: E(): 1.5e-12, (31.3% identity in 192 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142).; integral membrane protein	437518..438297	Mycobacterium tuberculosis H37Rv	886482
NP_214874.1	CDS	Rv0360c	NC_000962.2	438302	438739	R	Rv0360c, (MTCY13E10.22c), len: 145 aa. Conserved hypothetical protein, equivalent to AL023514|MLCB4_16|CAA18948.1|AL023514|MLCB4.27c hypothetical protein from Mycobacterium leprae (137 aa), FASTA scores: opt: 793, E(): 0, (85.4% identity in 137 aa overlap). And similar to AL049754|SCH10_25c|T36537 hypothetical protein from Streptomyces coelicolor (143 aa), FASTA scores: opt: 497, E(): 3.2e-27, (55.8% identity in 138 aa overlap).; hypothetical protein	complement(438302..438739)	Mycobacterium tuberculosis H37Rv	886480
NP_214875.1	CDS	Rv0361	NC_000962.2	438822	439649	D	Rv0361, (MTCY13E10.23), len: 275 aa. Probable conserved membrane protein (has hydrophobic stretch from residues 132-156), equivalent to AL023514|MLCB4_17|AA18949.1|AL023514 putative membrane protein from Mycobacterium leprae (292 aa), FASTA scores: opt: 1044, E(): 0, (58.6% identity in 292 aa overlap).; hypothetical protein	438822..439649	Mycobacterium tuberculosis H37Rv	886478
NP_214876.1	CDS	mgtE	NC_000962.2	439871	441253	D	Rv0362, (MTCY13E10.24), len: 460 aa. Possible mgtE, magnesium (Mg2+) transport transmembrane protein; C-terminal region is highly similar to MGTE|G780283 putative Mg2+ transporter from Providencia stuarti (314 aa), FASTA scores: E(): 0, (47.2% identity in 307 aa overlap) (N-terminus extends approx. 150 aa further upstream compared to P. stuarti ORF). Also similar in part to others e.g. AAK20879.1|AF334760_1|AF334760 putative Mg2+ transporter from Aeromonas hydrophila (455 aa); NP_231292.1|NC_002505 magnesium transporter from Vibrio cholerae (451 aa); NP_102305.1|NC_002678 Mg2+ transport protein from Mesorhizobium loti (454 aa); etc. Also similar to Rv1232c|MTV006.04c from Mycobacterium tuberculosis (435 aa). Extended hydrophobic segment spanning last 130 residues. BELONG TO THE MGTE FAMILY.; Mg2+ transport transmembrane protein MgtE	439871..441253	Mycobacterium tuberculosis H37Rv	886476
NP_214877.1	CDS	fba	NC_000962.2	441265	442299	R	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase	complement(441265..442299)	Mycobacterium tuberculosis H37Rv	886474
NP_214878.1	CDS	Rv0364	NC_000962.2	442395	443078	D	Rv0364, (MTCY13E10.26), len: 227 aa. Possible conserved transmembrane protein, equivalent to O69601|Y364_MYCLE|ML0287|CAA18951.1|AL023514|AL023514|MLC B4 _19 HYPOTHETICAL 24.3 KDA PROTEIN from Mycobacterium leprae (222 aa), FASTA scores: opt: 1027, E(): 0, (66.1% identity in 227 aa overlap). Shows strong similarity to DEDA_ECOLI|P09548 DedA PROTEIN protein from Escherichia coli FASTA scores: E(): 1.3e-28, (39.5% identity in 195 aa overlap). Similar also to Mycobacterium tuberculosis DedA protein Rv2637|MTCY441.0.; transmembrane protein	442395..443078	Mycobacterium tuberculosis H37Rv	886473
NP_214879.1	CDS	Rv0365c	NC_000962.2	443067	444197	R	Rv0365c, (MTCY13E10.27c), len: 376 aa (start uncertain). Conserved hypothetical protein (see citation below), very similar to G388212|CAA35191.1, a truncated ORF immediately upstream of the Corynebacterium glutamicum fda gene encoding fructose-1,6-biphosphate aldolase (304 aa), FASTA scores: E(): 7.1e-19, (42.2% identity in 296 aa overlap).; hypothetical protein	complement(443067..444197)	Mycobacterium tuberculosis H37Rv	886487
NP_214880.1	CDS	Rv0366c	NC_000962.2	444222	444815	R	Rv0366c, (MTV036.01c), len: 197 aa. Conserved hypothetical protein, showing weak similarity to HI1395|P44173|YD95_HAEIN HYPOTHETICAL PROTEIN from Haemophilus influenzae (140 aa), FASTA scores: opt: 152, E(): 0.0015, (27.0% identity in 126 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00850 Glycine radical signature. TBparse score is 0.891.; hypothetical protein	complement(444222..444815)	Mycobacterium tuberculosis H37Rv	886471
NP_214881.1	CDS	Rv0367c	NC_000962.2	444844	445233	R	Rv0367c, (MTV036.02c), len: 129 aa. Hypothetical unknown protein. TBparse score is 0.850.; hypothetical protein	complement(444844..445233)	Mycobacterium tuberculosis H37Rv	886468
NP_214882.1	CDS	Rv0368c	NC_000962.2	445314	446525	R	Rv0368c, (MTV036.03c), len: 403 aa. Conserved hypothetical protein, showing some similarity to AJ224684|BJAJ4684_4 cooxS protein from Bradyrhizobium japonicum (422 aa), FASTA scores: opt: 341, E(): 4.3e-13, (27.4% identity in 387 aa overlap); Rv2425c|MTCY428_22 hypothetical protein from Mycobacterium tuberculosis FASTA score: (30.7% identity in 238 aa overlap). Contains PS00213 Lipocalin signature. TBparse score is 0.909.; hypothetical protein	complement(445314..446525)	Mycobacterium tuberculosis H37Rv	886469
NP_214883.1	CDS	Rv0369c	NC_000962.2	446531	447046	R	Rv0369c, (MTV036.04c), len: 171 aa. Possible membrane protein oxidoreductase (EC 1.-.-.-), similar to ORF 4 of the Pseudomonas thermocarboxydovorans protein of cutA-cutB-cutC gene cluster: X77931|PTC2CUTAC_4 ORF4 from Pseudomonas thermocarboxydovorans (171 aa), FASTA scores: opt: 226, E(): 9.8e-08, (31.3% identity in 166 aa overlap). Also similar to MTV036.05, MTV036.08, MTV036.09, and MTV026.10.; membrane oxidoreductase	complement(446531..447046)	Mycobacterium tuberculosis H37Rv	886485
NP_214884.1	CDS	Rv0370c	NC_000962.2	447147	448043	R	Rv0370c, (MTV036.05c), len: 298 aa. Possible oxidoreductase (EC 1.-.-.-), similar to many hypothetical proteins, but also similar to ORF4|X82447|OCCOXMSL4_4 Protein of coxMSL gene cluster from Pseudomonas/Oligotropha carboxidovorans (295 aa), FASTA scores: opt: 851, E(): 0, (48.2% identity in 282 aa overlap); AJ224684|BJAJ4684_3 cooxS from Bradyrhizobium japonicum (302 aa), FASTA scores: opt: 881, E(): 0, (47.6% identity in 290 aa overlap). Also highly similar to MTCY428_21 from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.921.; oxidoreductase	complement(447147..448043)	Mycobacterium tuberculosis H37Rv	886465
NP_214885.1	CDS	Rv0371c	NC_000962.2	448040	448633	R	Rv0371c, (MTV036.06c), len: 197 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. AL132824|SCAH10.09c|CAB60163.1|AL132824 hypothetical protein from Streptomyces coelicolor (207 aa), FASTA scores: opt: 247, E(): 4.5e-09, (32.3% identity in 195 aa overlap). Also weak similarity with YURE|D70017|Z99120|BSUB0017_134 hypothetical protein yurE from Bacillus subtilis (197 aa), FASTA scores: opt: 217, E(): 2.5e-08, (27.0% identity in 174 aa overlap).; hypothetical protein	complement(448040..448633)	Mycobacterium tuberculosis H37Rv	886463
NP_214886.1	CDS	Rv0372c	NC_000962.2	448630	449385	R	Rv0372c, (MTV036.07c), len: 251 aa. Conserved hypothetical protein, showing some similarity with CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa); AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum (176 aa), FASTA scores: opt: 186, E(): 1.6e-05, (41.1% identity in 95 aa overlap). Also similar to upstream ORF Rv0376c from Mycobacterium tuberculosis (380 aa), FASTA scores: E(): 6.8e-07, (31.0% identity in 277 aa overlap). TBparse score is 0.862.; hypothetical protein	complement(448630..449385)	Mycobacterium tuberculosis H37Rv	886460
NP_214887.1	CDS	Rv0373c	NC_000962.2	449404	451803	R	Rv0373c, (MTV036.08c), len: 799 aa. Probable carbon monoxide dehydrogenase, large chain (EC 1.2.99.2), highly similar to others e.g. AAD00363.1| U80806|CUTL carbon monoxide dehydrogenase large subunit CutL protein from Hydrogenophaga pseudoflava (803 aa); S49124|509391|CAA54902.1|X77931|1094915|2107180C|CUTA carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) (cut operon) from Pseudomonas thermocarboxydovorans (842 aa); C56279|809566|CAA57829.1|X82447|OCCOXMSL4_3|COXL carbon-monoxide dehydrogenase large chain (EC 1.2.99.2) (cluster coxMSL) from Pseudomonas/Oligotropha carboxydovorans (809 aa), FASTA scores: opt: 2484, E(): 0, (56.0% identity in 804 aa overlap); etc.; carbon monoxyde dehydrogenase large subunit	complement(449404..451803)	Mycobacterium tuberculosis H37Rv	886472
NP_214888.1	CDS	Rv0374c	NC_000962.2	451800	452279	R	Rv0374c, (MTV036.09c), len: 159 aa. Probable carbon monoxide dehydrogenase, small chain (EC 1.2.99.2), highly similar to others e.g. B56279|5822285|X82447|OCCOXMSL4_2|COXS carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) from Pseudomonas/Oligotropha carboxydovorans (166 aa), FASTA scores: opt: 662, E(): 0, (59.3% identity in 150 aa overlap); CAA12063.1|AJ224684 putative carbon monoxide dehydrogenase small subunit from Bradyrhizobium japonicum (161 aa); S49123|509390|CAA54901.1|X77931|CUTC carbon-monoxide dehydrogenase small chain (EC 1.2.99.2) from Pseudomonas thermocarboxydovorans (163 aa); etc. TBparse score is 0.918.; carbon monoxyde dehydrogenase small subunit	complement(451800..452279)	Mycobacterium tuberculosis H37Rv	886462
NP_214889.1	CDS	Rv0375c	NC_000962.2	452294	453154	R	Rv0375c, (MTV036.10c), len: 286 aa. Probable carbon monoxide dehydrogenase, medium chain (EC 1.2.99.2), similar to others e.g. AAD00361.1|U80806|CUTM carbon monoxide dehydrogenase middle subunit from Hydrogenophaga pseudoflava (287 aa); S49122|509389|CAA54900.1|X77931|CUTB carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) from Pseudomonas thermocarboxydovorans (287 aa); A56279|809564|CAA57827.1|X82447|OCCOXMSL4_1|COXM|CODH carbon-monoxide dehydrogenase medium chain (EC 1.2.99.2) from Pseudomonas/Oligotropha carboxydovorans (288 aa), FASTA scores: opt: 594, E(): 0, (37.5% identity in 277 aa overlap); etc.; carbon monoxyde dehydrogenase medium subunit	complement(452294..453154)	Mycobacterium tuberculosis H37Rv	886456
NP_214890.1	CDS	Rv0376c	NC_000962.2	453230	454372	R	Rv0376c, (MTV036.11c), len: 380 aa. Conserved hypothetical protein, highly similar to T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical protein from Streptomyces coelicolor (395 aa); and AAK64260.1|AF373840_20 ORF377 hypothetical CoxI from Arthrobacter nicotinovorans (377 aa). And similar to other conserved hypothetical proteins e.g. NP_101963.1|14021136|BAB47749.1|AP002994 hypothetical protein from Mesorhizobium loti (245 aa). Note that C-terminus shows similarity with C-termini of CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa); CAB76250.1|X82447|COXI CoxI protein from Pseudomonas/Oligotropha carboxidovorans (330 aa); and AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum (176 aa), FASTA scores: E(): 1.9e-17, (47.1% identity in 138 aa overlap). Also some partial similarity with AJ224684|BJAJ4684_5 cooxS from Bradyrhizobium japonicum (107 aa), FASTA scores: opt: 321, E(): 4.2e-14, (53.3% identity in 92 aa overlap); E1184330|Z99120|YURF YURF PROTEIN from Bacillus subtilis (330 aa), FASTA scores: opt: 170, E(): 2.9e- 16, (27.5% identity in 345 aa overlap). Also similar to downstream ORF Rv0372c from Mycobacterium tuberculosis (251 aa), FASTA scores: E(): 2.1e-06, (30.7% identity in 277 aa overlap).; hypothetical protein	complement(453230..454372)	Mycobacterium tuberculosis H37Rv	886454
NP_214891.1	CDS	Rv0377	NC_000962.2	454421	455386	D	Rv0377, (MTV036.12), len: 321 aa. Probable transcription regulator, lysR family, showing similarity with many hypothetical transcriptional regulators lysR homolog e.g. P32484|YEIE_ECOLI|M89774 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli (293 aa), FASTA scores: opt: 265, E(): 4.9e-11, (28.6% identity in 266 aa overlap). Also similar to Rv2282c from Mycobacterium tuberculosis. Contains PS00044 bacterial regulatory protein lysR family signature. SEEMS TO BELONG TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.903.; LysR family transcriptional regulator	454421..455386	Mycobacterium tuberculosis H37Rv	886452
NP_214892.1	CDS	Rv0378	NC_000962.2	455637	455858	D	Rv0378, (MTV036.13), len: 73 aa. Conserved hypothetical gly-rich protein, showing some similarity to Mycobacterium tuberculosis PE_PGRS family; also similar to MTCY06H11_16|Z85982 hypothetical glycine-rich 88.5 KD protein (1011 aa), FASTA scores: opt: 237, E(): 0.0032, (58.7% identity in 63 aa overlap); MTV043_25. TBparse score is 0.860.; glycine rich protein	455637..455858	Mycobacterium tuberculosis H37Rv	886450
YP_177722.1	CDS	secE2	NC_000962.2	455977	456192	D	Rv0379, (MTV036.14), len: 71 aa. Possible secE2, protein transport protein, showing similarity with P27340|S61G_SULSO|SECE PREPROTEIN TRANSLOCASE SECE SUBUNIT (PROTEIN TRANSPORT PROTEIN SEC61 GAMMA SUBUNIT HOMOLOG) from Sulfolobus acidocaldarius (65 aa), FASTA scores: opt: 79, E(): 4.7. (30.3% identity in 66 aa overlap); and hypothetical proteins e.g. Q9HPW4|VNG1446H HYPOTHETICAL PROTEIN from Halobacterium sp. strain NRC-1 (77 aa); Q9I794|PA0038 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (71 aa); etc. Also highly similar to U85467|MTU85467_1 hypothetical Mycobacterium tuberculosis protein from a patient isolate (116 aa), FASTA scores: opt: 443, E(): 7.7e-29, (98.6% identity in 71 aa overlap). Note that for Rv0379|MTV036.14, a translation initiation region different to the one in U85467|MTU85467_1 was chosen. COULD BE A PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732.; protein transport protein	455977..456192	Mycobacterium tuberculosis H37Rv	886449
NP_214894.1	CDS	Rv0380c	NC_000962.2	456268	456819	R	Rv0380c, (MTV036.15c), len: 183 aa. Possible RNA methyltransferase (EC 2.1.1.-), equivalent to CAC32002.1|AL583925 possible RNA methyltransferase from Mycobacterium leprae (182 aa). Also some similarity with others methyltransferases e.g. P19396|TRMH_ECOLI|78514|JV0043 TRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE (TRNA METHYLTRANSFERASE) from Escherichia coli (229 aa), FASTA scores: opt: 227, E(): 1.4e-09, (28.9% identity in 166 aa overlap). Also similar to Rv0881, Rv3579c, Rv1644 from Mycobacterium tuberculosis.; RNA methyltransferase	complement(456268..456819)	Mycobacterium tuberculosis H37Rv	886446
NP_214895.1	CDS	Rv0381c	NC_000962.2	456915	457823	R	Rv0381c, (MTV036.16c), len: 302 aa. Hypothetical unknown protein. Equivalent to AAK44616.1 from Mycobacterium tuberculosis strain CDC1551 (254 aa) but longer 48 aa. TBparse score is 0.902.; hypothetical protein	complement(456915..457823)	Mycobacterium tuberculosis H37Rv	886444
YP_177723.1	CDS	pyrE	NC_000962.2	457841	458380	R	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase	complement(457841..458380)	Mycobacterium tuberculosis H37Rv	886443
NP_214897.1	CDS	Rv0383c	NC_000962.2	458461	459315	R	Rv0383c, (MTV036.18c), len: 284 aa. Possible conserved secreted protein, with hydrophobic stretch in N-terminus and Pro-rich C-terminus. Equivalent to CAC32006.1|AL583925 possible secreted protein from Mycobacterium leprae (286 aa). TBparse score is 0.900.; hypothetical protein	complement(458461..459315)	Mycobacterium tuberculosis H37Rv	886458
NP_214898.1	CDS	clpB	NC_000962.2	459456	462002	R	Rv0384c, (MTV036.19c), len: 848 aa. Probable clpB (alternate gene name: htpM), endopeptidase ATP-binding protein, chain B (EC 3.-.-.-), equivalent to AC32007.1|AL583925 heat shock protein from Mycobacterium leprae (848 aa). Also highly similar to others e.g. P53532|CLPB_CORGL|1163118|AAB49540.1|U43536|CGU43536_1 CLPB PROTEIN (heat-inducible expression) from Corynebacterium glutamicum (852 aa), FASTA scores: opt: 4113, E(): 0, (74.5% identity in 846 aa overlap); T36551|4753885|CAB42048.1|AL049754|clpB|SCOEDB|SCH10.39c probable ATP-dependent proteinase ATP-binding chain from Streptomyces coelicolor (853 aa); P03815|CLPB_ECOLI|1788943|AAC75641.1|AE000345 CLPB PROTEIN (HEAT SHOCK PROTEIN F84.1) from Escherichia coli strains K12 and O157:H7 (857 aa); etc. Also similar to Rv3596c|ClpC from Mycobacterium tuberculosis. Contains PS00870 and PS00871 Chaperonins clpA/B signatures and two PS000017 ATP/GTP-binding site motives A (P-loop). BELONGS TO THE CLPA/CLPB FAMILY. Contains probable coiled-coil domain from aa 411-503.; htpM; endopeptidase ATP binding protein	complement(459456..462002)	Mycobacterium tuberculosis H37Rv	886440
NP_214899.1	CDS	Rv0385	NC_000962.2	462135	463307	D	Rv0385, (MTV036.20), len: 390 aa. Probable monooxygenase (EC 1.-.-.-), similar to T37003|5738846|CAB52917.1|AL109949 probable flavohemoprotein from Streptomyces coelicolor (435 aa); and similar in part (C-termini) to various monooxygenases e.g. P19734|DMPP_PSESP|94993|F37831 PHENOL HYDROXYLASE P5 PROTEIN (PHENOL 2-MONOOXYGENASE P5 COMPONENT) (EC 1.14.13.7) from Pseudomonas putida (353 aa), FASTA scores: opt: 363, E(): 4.2e-16, (31.8% identity in 255 aa overlap); S47292|2120861|pir|S70085 phenol 2-monooxygenase (EC 1.14.13.7) chain mopP from Acinetobacter calcoaceticus (350 aa); P21394|XYLA_PSEPU|94933|B37316 XYLENE MONOOXYGENASE ELECTRON TRANSFER COMPONENT (EC 1.18.1.3) [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE] from Pseudomonas putida plasmid pWW0 (350 aa); AAC38360.1|AF043544|NtnMA|ntnA reductase component of 4-nitrotoluene monooxygenase from Pseudomonas sp. (328 aa); etc. TBparse score is 0.898.; hypothetical protein	462135..463307	Mycobacterium tuberculosis H37Rv	886441
NP_214900.1	CDS	Rv0386	NC_000962.2	463411	466668	D	Rv0386, (MTV036.21), len: 1085 aa. Probable regulatory protein, LuxR/uhpA family, highly similar to CAC30706.1|AL583923 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also similar in part to other regulatory proteins e.g. CAB95788.1|AL359949 putative multi-domain regulatory protein from Streptomyces coelicolor (780 aa); N-terminus of CAB92369.1|AL356612 putative AfsR-like regulatory protein from Streptomyces coelicolor (1114 aa); N-terminus of NP_107139.1|14026327|BAB52925.1|AP003009 transcriptional regulator from Mesorhizobium loti (952 aa); AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces coelicolor (993 aa), FASTA scores: opt: 224, E() : 1.1e-06, (26.1% identity in 867 aa overlap); etc. Also similar to many putative Mycobacterium tuberculosis regulatory proteins e.g. AL0212|MTV008_44 (1137 aa), FASTA scores: opt: 3756, E(): 0, (56.7% identity in 1089 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature and probable helix-turn-helix motif at aa 1042-1063 (Score 1025, +2.68 S D). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.910.; LuxR/UHPA family transcriptional regulator	463411..466668	Mycobacterium tuberculosis H37Rv	886030
NP_214901.1	CDS	Rv0387c	NC_000962.2	466672	467406	R	Rv0387c, (MTV036.22c), len: 244 aa. Conserved hypothetical protein, showing some similarity to MTCI237.20c, and M17282|HUMEL20_1 Human elastin gene, exon 1, Elastin (687 aa), FASTA scores: opt: 193, E(): 0.35, (34.4% identity in 189 aa overlap). TBparse score is 0.915.; PPE family protein	complement(466672..467406)	Mycobacterium tuberculosis H37Rv	886436
YP_177724.1	CDS	PPE9	NC_000962.2	467459	468001	R	Rv0388c, (MTV036.23c), len: 180 aa. Member of the Mycobacterium tuberculosis PPE family, highly similar to others e.g. MTCY10G2_10|Z92539 from Mycobacterium tuberculosis (391 aa), FASTA scores: opt: 667, E(): 0, (58.3% identity in 180 aa overlap) but much shorter.; PPE family protein	complement(467459..468001)	Mycobacterium tuberculosis H37Rv	886439
NP_214903.1	CDS	purT	NC_000962.2	468335	469594	D	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2	468335..469594	Mycobacterium tuberculosis H37Rv	886032
NP_214904.1	CDS	Rv0390	NC_000962.2	469591	470013	D	Rv0390, (MTCY04D9.02), len: 140 aa. Conserved hypothetical protein, equivalent to AL023514|MLCB4_11|CAA18942.1|AL023514 hypothetical protein from Mycobacterium leprae (147 aa), FASTA scores: opt: 778, E(): 0, (79.0% identity in 138 aa overlap). Also similar to hypothetical proteins from several Rickettsia species.; hypothetical protein	469591..470013	Mycobacterium tuberculosis H37Rv	886433
NP_214905.1	CDS	metZ	NC_000962.2	470010	471230	D	Rv0391, (MTCY04D9.03), len: 406 aa. Probable metZ, O-succinylhomoserine sulfhydrylase (EC 4.2.99.-), equivalent, but shorter 20 aa in N-terminus, to AA18941.1|AL023514 O-succinylhomoserine sulfhydrylase from Mycobacterium leprae (426 aa). Also highly similar to others e.g. METZ_PSEAE|P55218 o-succinylhomoserine sulfhydrylase from Pseudomonas aeruginosa (403 aa), FASTA scores: opt: 1175, E(): 0, (47.2% identity in 392 aa overlap); etc. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY. Could also be a cystathionine gamma-synthase (EC 4.2.99.9).; O-succinylhomoserine sulfhydrylase	470010..471230	Mycobacterium tuberculosis H37Rv	886431
NP_214906.1	CDS	ndhA	NC_000962.2	471227	472639	R	Rv0392c, (MTCY04D9.04c), len: 470 aa. Probable ndhA, membrane NADH dehydrogenase (EC 1.6.99.3), equivalent to many e.g. AF038423|AF038423_1 NADH dehydrogenase from Mycobacterium smegmatis (457 aa), FASTA scores: opt: 1991, E(): 0, (67.9% identity in 458 aa overlap); MLCB1788_3 NADH dehydrogenase from Mycobacterium leprae (466 aa), FASTA score: (62.5% identity in 467 aa overlap). Also similar to others from several organisms e.g. P00393|DHNA_ECOLI|66211|581140|CAA23586.1|V00306 NADH DEHYDROGENASE from Escherichia coli (434 aa); and Rv0392c|ndhB from Mycobacterium tuberculosis. Has hydrophobic stretch in C-terminus. BELONGS TO THE NADH DEHYDROGENASE FAMILY.; membrane NADH dehydrogenase	complement(471227..472639)	Mycobacterium tuberculosis H37Rv	886430
NP_214907.1	CDS	Rv0393	NC_000962.2	472781	474106	D	Rv0393, (MTCY04D9.05), len: 441 aa. Member of Mycobacterium tuberculosis 13E12 repeat family of conserved proteins, similar to many e.g. Rv1148c, Rv1945, Rv3467, Rv0336|MTCY279_3 (503 aa), FASTA scores: E(): 0, (61.1% identity in 347 aa overlap).; 13E12 repeat family protein	472781..474106	Mycobacterium tuberculosis H37Rv	886428
NP_214908.1	CDS	Rv0394c	NC_000962.2	474122	474841	R	Rv0394c, (MTCY04D9.06c), len: 239 aa. Possible secreted protein, sharing no homology with other proteins. Has hydrophobic stretch at its N-terminus.; hypothetical protein	complement(474122..474841)	Mycobacterium tuberculosis H37Rv	886435
NP_214909.1	CDS	Rv0395	NC_000962.2	474940	475344	D	Rv0395, (MTCY04D9.07), len: 134 aa. Hypothetical unknown protein.; hypothetical protein	474940..475344	Mycobacterium tuberculosis H37Rv	886425
NP_214910.1	CDS	Rv0396	NC_000962.2	475350	475742	D	Rv0396, (MTCY04D9.08), len: 130 aa. Hypothetical unknown protein.; hypothetical protein	475350..475742	Mycobacterium tuberculosis H37Rv	886423
NP_214911.1	CDS	Rv0397	NC_000962.2	475816	476184	D	Rv0397, (MTCY04D9.09), len: 122 aa. Part of 13E12 repeat family of conserved Mycobacterium tuberculosis proteins, similar to downstream Rv0393|Z84725|MTCY4D9_5 CONSERVED 13E12 REPEAT FAMILY PROTEIN (441 aa), FASTA scores: E(): 0, (87.7% identity in 122 aa overlap).; 13E12 repeat family protein	475816..476184	Mycobacterium tuberculosis H37Rv	886421
NP_214912.1	CDS	Rv0398c	NC_000962.2	476679	477320	R	Rv0398c, (MTCY04D9.10c), len: 213 aa. Possible secreted protein, sharing no homology with other proteins. Has potential signal sequence with hydrophobic stretch from aa 7-25.; hypothetical protein	complement(476679..477320)	Mycobacterium tuberculosis H37Rv	886419
NP_214913.1	CDS	lpqK	NC_000962.2	477327	478556	R	Rv0399c, (MTCY04D9.11c), len: 409 aa. Possible lpqK, conserved lipoprotein, showing some similarity to penicillin binding proteins and various peptidases e.g. DAC_STRSQ|P15555 d-alanyl-d-alanine carboxypeptidase protein (406 aa), FASTA scores: opt: 348, E(): 5.6e-16, (29.2% identity in 301 aa overlap). Also similar to other Mycobacterium tuberculosis PBPs and esterases. Has possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013).; lipoprotein LpqK	complement(477327..478556)	Mycobacterium tuberculosis H37Rv	886416
NP_214914.1	CDS	fadE7	NC_000962.2	478566	479753	R	Rv0400c, (MTCY04D9.12c), len: 395 aa. Probable fadE7, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. CAC12923.1|AL445403 putative acyl CoA dehydrogenase from Streptomyces coelicolor (397 aa); G624219 GLUTARYL-CoA DEHYDROGENASE PRECURSOR (438 aa), FASTA scores: opt: 1161, E(): 0, (48.1% identity in 391 aa overlap); etc.; acyl-CoA dehydrogenase FADE7	complement(478566..479753)	Mycobacterium tuberculosis H37Rv	886427
NP_214915.1	CDS	Rv0401	NC_000962.2	479789	480160	D	Rv0401, (MTCY04D9.14), len: 129 aa. Probable conserved transmembrane protein, equivalent to AL023514|MLCB4_9 putative integral membrane protein from Mycobacterium leprae (122 aa), FASTA scores: opt: 548, E(): 4.4e-32, (66.9% identity in 121 aa overlap).; transmembrane protein	479789..480160	Mycobacterium tuberculosis H37Rv	886438
NP_214916.1	CDS	mmpL1	NC_000962.2	480355	483231	R	Rv0402c, (MTCY04D9.15c), len: 958 aa. Probable mmpL1, conserved transmembrane transport protein (see Tekaia et al., 1999), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCTU|Q11171 hypothetical 106.2 kDa membrane protein from Mycobacterium tuberculosis (968 aa), FASTA scores: opt: 3551, E(): 0, (55.4% identity in 933aa overlap); YV34_MYCLE|P54881 hypothetical 105.2 kDa protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3615, E(): 0, (55.5% identity in 941 aa overlap); etc. Highly similar to many other mycobacterial MmpL proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. Rv0450c, Rv0676c, Rv0507, etc. BELONGS TO THE MMPL FAMILY.; transmembrane transport protein MmpL1	complement(480355..483231)	Mycobacterium tuberculosis H37Rv	886413
NP_214917.1	CDS	mmpS1	NC_000962.2	483228	483656	R	Rv0403c, (MTCY04D9.16c), len: 142 aa. Probable mmpS1, conserved membrane protein (see citation below), highly similar to other Mycobacterial proteins e.g. YV33_MYCLE|P54880 hypothetical 16.9 kDa protein from Mycobacterium leprae (154 aa), FASTA scores: opt: 458, E(): 1.6e-26, (46.9% identity in 143 aa overlap); YV33_MYCTU|Q11170 hypothetical 15 .9 kDa protein from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 362, E(): 1.1e-19, (42.1% identity in 140 aa overlap); etc. Also similar to other MmpS proteins from Mycobacterium tuberculosis e.g. Rv0677c, Rv0451c, etc. BELONGS TO THE MMPS FAMILY.; membrane protein	complement(483228..483656)	Mycobacterium tuberculosis H37Rv	886411
NP_214918.1	CDS	fadD30	NC_000962.2	483977	485734	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	483977..485734	Mycobacterium tuberculosis H37Rv	886409
NP_214919.1	CDS	pks6	NC_000962.2	485731	489939	D	Rv0405, (MTCY22G10.01), len: 1402 aa. Probable pks6, membrane-bound polyketide synthase (see citation below), highly similar to others e.g. CAC29643.1|AL583917 putative polyketide synthase from Mycobacterium leprae (2103 aa); Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa), FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, 2 x PS00017 ATP/GTP-binding site motif A (P-loop), and PS00012 Phosphopantetheine attachment site.; membrane bound polyketide synthase	485731..489939	Mycobacterium tuberculosis H37Rv	886407
NP_214920.1	CDS	Rv0406c	NC_000962.2	489887	490705	R	Rv0406c, (MTCY22G10.02c), len: 272 aa. Beta-lactamase-like protein, equivalent to AAD38170.1|AF152397_1 beta-lactamase-like protein from Mycobacterium phlei (243 aa); AL023514|MLCB4_8 hypothetical protein from Mycobacterium leprae (251 aa), FASTA scores: opt: 1284, E(): 0, (74.9% identity in 243 aa overlap); and AAD38164.1|AF152394_2 beta-lactamase-like protein from Mycobacterium avium (247 aa), FASTA scores: opt: 1301, E(): 0, (74.2% identity in 244 aa overlap); etc. Also slight similarity to others beta-lactamases and hypothetical proteins e.g. P52700|BLA1_XANMA|628530|S45349 METALLO-BETA-LACTAMASE L1 PRECURSOR (BETA-LACTAMASE, TYPE II) (PENICILLINASE) from Xanthomonas maltophilia (290 aa), FASTA scores: (34.4% identity in 96 aa overlap).; beta lactamase like protein	complement(489887..490705)	Mycobacterium tuberculosis H37Rv	886403
NP_214921.1	CDS	fgd1	NC_000962.2	490783	491793	D	Rv0407, (MTCY22G10.03), len: 336 aa. Probable fgd1, F420-dependent glucose-6-phosphate dehydrogenase (EC 1.-.-.-), equivalent to others from Mycobacteria e.g. AAD38165.1|AF152394_3 from Mycobacterium avium (336 aa), FASTA scores: opt: 2082, E(): 0, (89.9% identity in 336 aa overlap); AL023514|MLCB 4_7 from Mycobacterium leprae (336 aa), FASTA scores: opt: 2069, E(): 0, (89.0% identity in 336 aa overlap). Also similar to other dehydrogenases e.g. CAA77276.1|Y18730 F420-dependent alcohol dehydrogenase from Methanofollis liminatans (330 aa). Also similar to many proteins from Mycobacterium tuberculosis e.g. Rv0953c, Rv0791c, etc. Note that previously known as fgd.; fgd; F420-dependent glucose-6-phosphate dehydrogenase	490783..491793	Mycobacterium tuberculosis H37Rv	886418
NP_214922.1	CDS	pta	NC_000962.2	491786	493858	D	catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase	491786..493858	Mycobacterium tuberculosis H37Rv	886401
NP_214923.1	CDS	ackA	NC_000962.2	493851	495008	D	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase	493851..495008	Mycobacterium tuberculosis H37Rv	886399
NP_214924.1	CDS	pknG	NC_000962.2	495062	497314	R	Rv0410c, (MTCY22G10.06c), len: 750 aa. pknG, serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), equivalent to PKNG_MYCLE|P57993|13092623|CAC29812.1|AL583918 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium leprae (767 aa). Also similar to others e.g. AB76890.1|AL159139 putative serine/threonine protein kinase from Streptomyces coelicolor (774 aa); etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.; serine/threonine-protein kinase PKNG (protein kinase G) (STPK G)	complement(495062..497314)	Mycobacterium tuberculosis H37Rv	886397
NP_214925.1	CDS	glnH	NC_000962.2	497314	498300	R	Rv0411c, (MTCY22G10.07c), len: 328 aa. Probable glnH, glutamine-binding protein, membrane-bound lipoprotein (see citation below), equivalent to AL035159|MLCB1450_15|T44736|4154051|CAA22704.1 glutamine-binding protein homolog from Mycobacterium leprae (325 aa), FASTA scores: opt: 1747, E(): 0, (79.3% identity in 328 aa overlap). Also similar to others e.g. GLNH_BACST|P27676 glutamine-binding protein precursor from Bacillus stearothermophilus (262 aa), FASTA scores: opt: 493, E(): 7.5e-22, (37.8% identity in 193 aa overlap); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 3. Presumed attached to the membrane by a lipid anchor.; glutamine-binding lipoprotein	complement(497314..498300)	Mycobacterium tuberculosis H37Rv	886393
NP_214926.1	CDS	Rv0412c	NC_000962.2	498300	499619	R	Rv0412c, (MTCY22G10.08c), len: 439 aa. Possible conserved membrane protein, equivalent to AL035159|MLCB1450_16|T44737 probable membrane protein from Mycobacterium leprae (403 aa), FASTA scores: opt: 2027, E(): 0, (80.4% identity in 403 aa overlap). Also some similarity with CAB71201.1|AL138538 putative secreted protein from Streptomyces coelicolor (429 aa).; hypothetical protein	complement(498300..499619)	Mycobacterium tuberculosis H37Rv	886415
NP_214927.1	CDS	mutT3	NC_000962.2	499713	500366	D	Rv0413, (MTCY22G10.10), len: 217 aa. Possible mutT3, mutator protein (EC 3.6.1.-) (see citation below), showing some similarity with e.g. MUTT_PROVU|P32090 mutator mutt protein from Proteus vulgaris (112 aa), FASTA scores: opt: 151, E(): 0.0008, (40.7% identity in 59 aa overlap). SEEMS TO BELONG TO THE NUDIX HYDROLASE FAMILY.; 7,8-dihydro-8-oxoguanine-triphosphatase	499713..500366	Mycobacterium tuberculosis H37Rv	886405
NP_214928.1	CDS	thiE	NC_000962.2	500350	501018	R	Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase	complement(500350..501018)	Mycobacterium tuberculosis H37Rv	886391
NP_214929.1	CDS	thiO	NC_000962.2	501148	502170	D	Rv0415, (MTCY22G10.12), len: 340 aa. Possible thiO, thiamine biosynthesis oxidoreductase (EC 1.-.-.-), equivalent to T44739|4154054|CAA22708.1|AL035159|MLCB1450.24 hypothetical protein from Mycobacterium leprae (340 aa), FASTA scores: opt: 1867, E(): 0, (82.0% identity in 338 aa overlap). Shows some similarity to other thiO proteins e.g. THIO_RHIET|O34292 Putative thiamine biosynthesis oxidoreductase from Rhizobium etli plasmid pb (327 aa) (see citation below); AAG31046.1|AF264948_8|THIO putative amino acid oxidase flavoprotein ThiO from Erwinia amylovora (349 aa); NP_106392.1|14025578|BAB52178.1|AP003007|THIO THIAMINE BIOSYNTHESIS OXIDOREDUCTASE THIO from Mesorhizobium loti (333 aa); etc.; thiamine biosynthesis oxidoreductase ThiO	501148..502170	Mycobacterium tuberculosis H37Rv	886390
NP_214930.1	CDS	thiS	NC_000962.2	502167	502373	D	with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS	502167..502373	Mycobacterium tuberculosis H37Rv	886395
NP_214931.1	CDS	thiG	NC_000962.2	502366	503124	D	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase	502366..503124	Mycobacterium tuberculosis H37Rv	886396
NP_214932.1	CDS	lpqL	NC_000962.2	503496	504998	D	Rv0418, (MTCCY22G10.15), len: 500 aa. Probable lpqL, lipoprotein aminopeptidase (EC 3.4.11.-), similar to others e.g. B83278|9949035|AAG06327.1|AE004720_3|AE004720|PA2939 probable aminopeptidase from Pseudomonas aeruginosa (536 aa); P80561|APX_STRGR|SGAP|S66427 aminopeptidase (EC 3.4.11.-) from Streptomyces griseus (284 aa) (homology only with C-terminus of Rv0418); P37302|APE3_YEAST|1077010|A54134 aminopeptidase Y (EC 3.4.11.-) from Saccharomyces cerevisiae (537 aa); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein aminopeptidase LpqL	503496..504998	Mycobacterium tuberculosis H37Rv	886381
NP_214933.1	CDS	lpqM	NC_000962.2	505086	506582	D	Rv0419, (MTCY22G10.16), len: 498 aa. Possible lpqM, lipoprotein peptidase (EC 3.4.-.-); has potential N-terminal signal peptide and contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.; lipoprotein peptidase LpqM	505086..506582	Mycobacterium tuberculosis H37Rv	886388
NP_214934.1	CDS	Rv0420c	NC_000962.2	506561	506971	R	Rv0420c, (MTCY22G10.17c), len: 136 aa. Possible transmembrane protein; has potential transmembrane domains aa 53-99 and aa 100-122.; transmembrane protein	complement(506561..506971)	Mycobacterium tuberculosis H37Rv	886383
NP_214935.1	CDS	Rv0421c	NC_000962.2	507132	507761	R	Rv0421c, (MTCY22G10.18c), len: 209 aa. Conserved hypothetical protein, showing similarity with NP_103507.1|14022684|BAB49293.1|AP002998 hypothetical protein from Mesorhizobium loti (214 aa).; hypothetical protein	complement(507132..507761)	Mycobacterium tuberculosis H37Rv	886377
NP_214936.1	CDS	thiD	NC_000962.2	507758	508555	R	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase	complement(507758..508555)	Mycobacterium tuberculosis H37Rv	886375
NP_214937.1	CDS	thiC	NC_000962.2	508582	510225	R	required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC	complement(508582..510225)	Mycobacterium tuberculosis H37Rv	886379
NP_214938.1	CDS	Rv0424c	NC_000962.2	510377	510652	R	Rv0424c, (MTCY22G10.21c), len: 91 aa. Hypothetical unknown protein.; hypothetical protein	complement(510377..510652)	Mycobacterium tuberculosis H37Rv	886374
NP_214939.1	CDS	ctpH	NC_000962.2	510702	515321	R	Rv0425c, (MTCY22G10.22c), len: 1539 aa. Possible ctpH, metal cation-transporting P-type ATPase (transmembrane protein) (EC 3.6.1.-), showing some similarity with CAA17934.1|AL022118|13093871|CAC32203.1|AL583926 putative cation-transporting ATPase from Mycobacterium leprae (1609 aa). Also similar to others ATPases e.g. AE000873_1 CATION-TRANSPORTING P-ATPASE from Methanobacterium thermoautotrop (844 aa), FASTA score: (30.5% identity in 827 aa overlap); AB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); etc. C-terminal region similar to other ATPases from Mycobacterium tuberculosis e.g. Y05Q_MYCTU|Q10900 putative cation-transporting ATPase C (855 aa), FASTA scores: opt: 770, E(): 5.3e-32, (44.9% identity in 820 aa overlap).; metal cation transporting P-type ATPase CtpH	complement(510702..515321)	Mycobacterium tuberculosis H37Rv	886373
NP_214940.1	CDS	Rv0426c	NC_000962.2	515373	515816	R	Rv0426c, (MTCY22G10.23c), len: 147 aa. Possible transmembrane protein; has potential transmembrane domains aa 19-41, and aa 61-83.; hypothetical protein	complement(515373..515816)	Mycobacterium tuberculosis H37Rv	886387
NP_214941.1	CDS	xthA	NC_000962.2	516017	516892	R	Rv0427c, (MTCY22G10.24c), len: 291 aa. Probable xthA (alternate gene name: xth), exodeoxyribonuclease III protein (EC 3.1.11.2) (see citation below), similar to others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia Coli strain K12 (268 aa), FASTA scores: opt: 360, E(): 1.2e-17, (29.3% identity in 270 aa overlap); etc. BELONGS TO THE AP/EXOA FAMILY OF DNA REPAIR ENZYMES.; xth; exodeoxyribonuclease III protein	complement(516017..516892)	Mycobacterium tuberculosis H37Rv	886370
NP_214942.1	CDS	Rv0428c	NC_000962.2	516895	517803	R	Rv0428c, (MTCY22G10.25c), len: 302 aa. Hypothetical unknown protein.; hypothetical protein	complement(516895..517803)	Mycobacterium tuberculosis H37Rv	886368
NP_214943.1	CDS	def	NC_000962.2	517803	518396	R	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase	complement(517803..518396)	Mycobacterium tuberculosis H37Rv	886366
NP_214944.1	CDS	Rv0430	NC_000962.2	518733	519041	D	Rv0430, (MTCY22G10.27), len: 102 aa. Conserved hypothetical protein, equivalent to AC30882.1|AL583923 conserved hypothetical protein from Mycobacterium leprae (102 aa). Also highly similar to CAB93047.1|SCD95A.20|AL357432 hypothetical protein from Streptomyces coelicolor (84 aa).; hypothetical protein	518733..519041	Mycobacterium tuberculosis H37Rv	886364
NP_214945.1	CDS	Rv0431	NC_000962.2	519073	519567	D	Rv0431, (MTCY22G10.28), len: 164 aa. Putative tuberculin related peptide; almost identical to D00815|MSGAT103_1 AT103 from Mycobacterium tuberculosis (172 aa), FASTA score: (99.4% identity in 163 aa overlap). Highly similar to to CAC30881.1|AL583923 tuberculin related peptide (AT103) from Mycobacterium leprae (167 aa). Some similarity to G550415|HRPC (282 aa), FASTA scores: opt: 120, E(): 0.36, (33.3% identity in 111 aa overlap). Potential transmembrane domain at aa 19-37.; putative tuberculin related peptide	519073..519567	Mycobacterium tuberculosis H37Rv	886362
NP_214946.1	CDS	sodC	NC_000962.2	519600	520322	D	Rv0432, (MTCY22G10.29), len: 240 aa. Probable sodC, periplasmic superoxide dismutase [Cu-Zn] (EC 1.15.1.1), equivalent to CAC30880.1|AL583923 superoxide dismutase precursor (Cu-Zn) from Mycobacterium leprae (240 aa); and AAK20038.1|AF326234_1 copper zinc superoxide dismutase from Mycobacterium avium subsp. paratuberculosis (226 aa). Also similar to others e.g. SODC_PHOLE|P00446 superoxide dismutase precursor (cu-zn) from Photobacterium leiognathi (173 aa), FASTA scores: opt: 214, E(): 5.2 e-06, (36.5% identity in 181 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. BELONGS TO THE CU-ZN SUPEROXIDE DISMUTASE FAMILY. Possibly localized in periplasm, membrane-bound.; periplasmic superoxide dismutase [Cu-Zn] SodC	519600..520322	Mycobacterium tuberculosis H37Rv	886358
NP_214947.1	CDS	Rv0433	NC_000962.2	520324	521454	D	ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase	520324..521454	Mycobacterium tuberculosis H37Rv	886356
NP_214948.1	CDS	Rv0434	NC_000962.2	521514	522167	D	Rv0434, (MTCY22G10.31), len: 217 aa. Conserved hypothetical protein, similar to AE002052_2 from Deinococcus radiodurans (213 aa), FASTA scores: opt: 258, E(): 4e-10, (31.9% identity in 213 aa overlap); SYCSLRB_122|Q55701 hypothetical 24.5 kDa protein from Synechocystis (214 aa), FASTA scores: opt: 156, E(): 0.00041, (28.4% identity in 204 aa overlap); MXABSGA_1|LON2_MYXXA|P36774 ATP-dependent protease la 2 from Myxococcus xanthus (826 aa), FASTA scores: opt: 160, E(): 0.00068, (28.4% identity in 197 aa overlap); etc.; hypothetical protein	521514..522167	Mycobacterium tuberculosis H37Rv	886360
NP_214949.1	CDS	Rv0435c	NC_000962.2	522347	524533	R	Rv0435c, (MTCY22G10.32c), len: 728 aa. Putative conserved ATPase (EC 3.6.1.-), similar to others e.g. SAV_SULAC|Q07590 sav protein involved in cell division from sulfolobus acidocaldarius (780 aa), FASTA scores: opt: 897, E(): 0, (34.5% identity in 693 aa overlap); NP_148637.1|7435761|B72479 transitional endoplasmic reticulum ATPase from Aeropyrum pernix (699 aa); etc. Also similar to Rv3610c and Rv2115c from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00674 AAA-protein family signature.; putative ATPase	complement(522347..524533)	Mycobacterium tuberculosis H37Rv	886352
NP_214950.1	CDS	pssA	NC_000962.2	524530	525390	R	Rv0436c, (MTCY22G10.33c), len: 286 aa. Probable pssA, PS synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase) (EC 2.7.8.8) (see citation below), integral membrane protein, equivalent to AL035159|MLCB1450_9|T44730 from Mycobacterium leprae (300 aa), FASTA scores: opt: 1506, E(): 0, (77.9% identity in 285 aa overlap). Also highly similar to others e.g. NP_108059.1|14027250|BAB54204.1|AP003012 phosphatidylserine synthase from Mesorhizobium loti (248 aa); PSS_BACSU|P39823 cdp-diacylglycerol--serine o-phosphatidyltransferase from Bacillus subtilis (177 aa), FASTA scores: opt: 277, E(): 9.9e-12, (33.3% identity in 183 aa overlap); etc. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY.; CDP-diacylglycerol--serine O-phosphatidyltransferase	complement(524530..525390)	Mycobacterium tuberculosis H37Rv	886385
NP_214951.1	CDS	psd	NC_000962.2	525387	526082	R	catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase	complement(525387..526082)	Mycobacterium tuberculosis H37Rv	886350
YP_177725.1	CDS	moeA2	NC_000962.2	526143	527360	R	Rv0438c, (MTV037.02c), len: 405 aa. Probable moeA2, molybdenum cofactor biosynthesis protein, highly similar to many e.g. Y10817|ANY10817_2 from A. nicotinovorans (429 aa), FASTA scores: opt: 786, E(): 0, (39.2% identity in 398 aa overlap); etc. Also similar to MOEA1|Rv0994|MTCI237.08|O05577 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (426 aa), FASTA scores: opt: 667, E(): 2e-32, (36.5% identity in 425 aa overlap). TBparse score is 0.889. Note that previously known as moeA3.; moeA3; molybdopterin biosynthesis protein MoeA2	complement(526143..527360)	Mycobacterium tuberculosis H37Rv	886348
NP_214953.1	CDS	Rv0439c	NC_000962.2	527379	528314	R	Rv0439c, (MTV037.03c), len: 311 aa. Probable dehydrogenase/reductase (EC 1.-.-.-), equivalent to AL035159|MLCB1450_6|T44727 probable oxidoreductase from Mycobacterium leprae (304 aa), FASTA scores: opt: 1360, E(): 0, (69.2% identity in 302 aa overlap). Also highly similar to various oxidoreductases, generally dehydrogenases/reductases e.g. PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916 probable short chain dehydrogenase from Pseudomonas aeruginosa (309 aa); Q03326|OXIR_STRAT PROBABLE OXIDOREDUCTASE from Streptomyces antibioticus (298 aa), FASTA scores: opt: 400, E(): 1.2e-18, (34.6% identity in 298 aa overlap); etc. TBparse score is 0.903.; short chain dehydrogenase	complement(527379..528314)	Mycobacterium tuberculosis H37Rv	886342
NP_214954.1	CDS	groEL	NC_000962.2	528608	530230	D	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL	528608..530230	Mycobacterium tuberculosis H37Rv	886354
NP_214955.1	CDS	Rv0441c	NC_000962.2	530296	530724	R	Rv0441c, (MTV037.05c), len: 142 aa. Hypothetical unknown protein. TBparse score is 0.897.; hypothetical protein	complement(530296..530724)	Mycobacterium tuberculosis H37Rv	886344
YP_177726.1	CDS	PPE10	NC_000962.2	530751	532214	R	Rv0442c, (MTV037.06c), len: 487 aa. Member of the Mycobacterium tuberculosis PPE family, nearly identical to hypothetical protein from Mycobacterium tuberculosis (strain Erdman) and to AN5S46909_1 protein fragment from Mycobacterium bovis (302 aa); P42611|YHS6_MYCTU HYPOTHETICAL 50.6 kDa PROTEIN (517 aa), FASTA scores: opt: 3144, E(): 0, (98.4 identity in 492 aa overlap); and S46909|S46909_1 (302 aa), FASTA scores: opt: 1897, E(): 0, (98.0% identity in 302 aa overlap). TBparse score is 0.903.; PPE family protein	complement(530751..532214)	Mycobacterium tuberculosis H37Rv	886340
NP_214957.1	CDS	Rv0443	NC_000962.2	532396	532911	D	Rv0443, (MTV037.07), len: 171 aa. Conserved hypothetical protein, highly similar to AL049863|SC5H1_23|T35339 hypothetical protein from Streptomyces coelicolor (171 aa), FASTA scores: opt: 561, E(): 2.3e-32, (49.7% identity in 165 aa overlap); and CAC42482.1|AJ318385 hypothetical protein from Amycolatopsis mediterranei (163 aa). TBparse score is 0.915.; hypothetical protein	532396..532911	Mycobacterium tuberculosis H37Rv	886336
NP_214958.1	CDS	Rv0444c	NC_000962.2	533091	533789	R	Rv0444c, (MTV037.08c), len: 232 aa. Conserved hypothetical protein; C-terminus similar to P12752|Y24K_STRGR HYPOTHETICAL 24.7 kDa PROTEIN from Streptomyces griseus (238 aa), FASTA scores: opt: 207, E(): 2.2e-05, (32.9% identity in 158 aa overlap). TBparse score is 0.914.; hypothetical protein	complement(533091..533789)	Mycobacterium tuberculosis H37Rv	886346
NP_214959.1	CDS	sigK	NC_000962.2	533833	534396	R	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; RNA polymerase sigma factor SigK	complement(533833..534396)	Mycobacterium tuberculosis H37Rv	886334
NP_214960.1	CDS	Rv0446c	NC_000962.2	534445	535215	R	Rv0446c, (MTV037.10c), len: 256 aa. Possible conserved transmembrane protein, similar at N-terminus to U1740AF|U15183|MLU15183_40 from Mycobacterium leprae (117 aa), FASTA scores: opt: 175, E(): 2.5e-05, (62.5% identity in 40 aa overlap); and at C-terminus to AL021529|SC10A5_3 from Streptomyces coelicolor (226 aa), FASTA scores: opt: 207, E(): 9.8e-07, (34.2% identity in 114 aa overlap). Also similar to others hypothetical proteins e.g. AAK04680.1|AE006291_14|AE006291) HYPOTHETICAL PROTEIN from Lactococcus lactis subsp. lactis (257 aa). TBparse score is 0.920.; transmembrane protein	complement(534445..535215)	Mycobacterium tuberculosis H37Rv	886332
NP_214961.1	CDS	ufaA1	NC_000962.2	535224	536507	R	Rv0447c, (MTV037.11c), len: 427 aa (start uncertain). Probable ufaA1, cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79), similar to others e.g. NP_102178.1|14021351|BAB47964.1|AP002994 cyclopropane-fatty-acyl-phospholipid synthase from Mesorhizobium loti (378 aa); B82240|9655593|AAF94281.1|AE004192 cyclopropane-fatty-acyl-phospholipid synthase from Vibrio cholerae (432 aa); P30010|CFA_ECOLI CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Escherichia coli strain K-12 (382 aa); X55704|PPLPD_3 LPD-3 from P.putida (394 aa), FASTA scores: opt: 556, E(): 2.8e-30, (33.3% identity in 387 aa overlap); AE0005|HPAE000557_9 from Helicobacter pylori (389 aa), FASTA scores: opt: 539, E(): 3.9e-29, (34.3% identity in 382 aa overlap). TBparse score is 0.919.; cyclopropane-fatty-acyl-phospholipid synthase	complement(535224..536507)	Mycobacterium tuberculosis H37Rv	886330
NP_214962.1	CDS	Rv0448c	NC_000962.2	536504	537169	R	Rv0448c, (MTV037.12c), len: 221 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. Z74841|BOD5A2_1 from B. oleracea (283 aa), FASTA scores: opt: 257, E(): 1.4e-10, (32.0% identity in 197 aa overlap); etc. Some similarity to U15183|MLU15183_38 from Mycobacterium leprae (82 aa), FASTA scores: opt: 134, E(): 0.014, (71.0% identity in 31 aa overlap). TBparse score is 0.934.; hypothetical protein	complement(536504..537169)	Mycobacterium tuberculosis H37Rv	886328
NP_214963.1	CDS	Rv0449c	NC_000962.2	537229	538548	R	Rv0449c, (MTV037.13c), len: 439 aa. Conserved hypothetical protein, some similarity with several hypothetical proteins and various enzymes e.g. AAK24569.1|AE005927 amine oxidase, flavin-containing from Caulobacter crescentus (454 aa); BAB02771.1|AB023036 mycolic acid methyl transferase-like protein from Arabidopsis thaliana (842 aa); BAB01742.1|AP000374 protein which contains similarity to cyclopropane fatty acid synthase from Arabidopsis thaliana (793 aa); etc. Has hydrophobic stretch at N-terminus. TBparse score is 0.903.; hypothetical protein	complement(537229..538548)	Mycobacterium tuberculosis H37Rv	886326
NP_214964.1	CDS	mmpL4	NC_000962.2	538588	541491	R	Rv0450c, (MTV037.14c), len: 967 aa. Probable mmpL4, conserved transmembrane transport protein (see citations below), member of RND superfamily, equivalent to U1740V|P54881|YV34_MYCLE HYPOTHETICAL 105.2 kDa PROTEIN from Mycobacterium leprae (959 aa), FASTA scores: opt: 5051, E(): 0, (78.4% identity in 962 aa overlap). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. Z83860|MTCY98.08 (962 aa), FASTA scores: opt: 3917, E(): 0, (61.3% identity in 950 aa overlap), MTCY20G9.34, etc. Contains PS00211 ABC transporters family signature. BELONGS TO THE MMPL FAMILY. TBparse score is 0.948.; transmembrane transport protein MmpL4	complement(538588..541491)	Mycobacterium tuberculosis H37Rv	886323
NP_214965.1	CDS	mmpS4	NC_000962.2	541488	541910	R	Rv0451c, (MTV037.15c), len: 140 aa. Probable mmpS4, conserved membrane protein (see citations below), equivalent to U1740W|P54880|YV33_MYCLE HYPOTHETICAL 16.9 kDa PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 727, E(): 0, (75.9% identity in 137 aa overlap). Also similar to other Mycobacterial proteins e.g. Z84725|MTCY04D9.16c from Mycobacterium tuberculosis (142 aa), FASTA scores: opt: 451, E(): 3.2e-24, (50.0% identity in 138 aa overlap); etc. BELONGS TO THE MMPS FAMILY. TBparse score is 0.953.; membrane protein	complement(541488..541910)	Mycobacterium tuberculosis H37Rv	886321
NP_214966.1	CDS	Rv0452	NC_000962.2	542142	542852	D	Rv0452, (MTV037.16), len: 236 aa. Possible transcriptional regulator, similar to several putative TetR-family transcriptional regulators from Streptomyces coelicolor. Also similar in N-terminus to U1740Y|U15183|MLU15183_33 from Mycobacterium leprae (67 aa), FASTA score: (76.1% identity in 67 aa overlap). Contains probable helix-turn-helix motif at aa 44-65 (Score 1727, +5.07 SD). TBparse score is 0.914.; transcriptional regulatory protein	542142..542852	Mycobacterium tuberculosis H37Rv	886319
YP_177727.1	CDS	PPE11	NC_000962.2	543174	544730	D	Rv0453, (MTV037.17), len: 518 aa. Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 882, E(): 7e-31, (41.8% identity in 514 aa overlap). TBparse score is 0.922.; PPE family protein	543174..544730	Mycobacterium tuberculosis H37Rv	886317
NP_214968.1	CDS	Rv0454	NC_000962.2	544835	545185	D	Rv0454, (MTV037.18), len: 116 aa (start uncertain). Conserved hypothetical protein, showing similarity with AAA63007.1|U15183 hypothetical protein from Mycobacterium leprae (115 aa), FASTA scores: opt: 151, E(): 0.0019, (31.5% identity in 89 aa overlap).; hypothetical protein	544835..545185	Mycobacterium tuberculosis H37Rv	886339
NP_214969.1	CDS	Rv0455c	NC_000962.2	545375	545821	R	Rv0455c, (MTV037.19c), len: 148 aa. Conserved hypothetical protein, equivalent to CAC31896.1|AL583925 possible secreted protein from Mycobacterium leprae (153 aa). Has hydrophobic stretch at N-terminus. TBparse score is 0.947.; hypothetical protein	complement(545375..545821)	Mycobacterium tuberculosis H37Rv	886314
NP_214970.1	CDS	echA2	NC_000962.2	545889	546803	R	catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	complement(545889..546803)	Mycobacterium tuberculosis H37Rv	886312
YP_177621.1	CDS	Rv0456A	NC_000962.2	547076	547357	R	Rv0456A, len: 93 aa. Conserved hypothetical protein; N-terminus highly similar to N-terminal part of P71650|Rv2801c|MT2869|MTCY16B7.42 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (118 aa), FASTA scores: opt: 303, E(): 1e-14, (60.44% identity in 91 aa overlap). Also some similarity in part with other hypothetical proteins e.g. Q9PHH8|XFA0027 Plasmid maintenance protein from Xylella fastidiosa (108 aa), FASTA scores: opt: 169, E(): 3.9e-05, (50.820% identity in 61 aa overlap).; hypothetical protein	complement(547076..547357)	Mycobacterium tuberculosis H37Rv	3205039
NP_214971.1	CDS	Rv0457c	NC_000962.2	547586	549607	R	Rv0457c, (MTCI429A.01, MTV038.01c), len: 673 aa. Probable peptidase (EC 3.4.-.-), similar to many e.g. NP_102851.1|14022026|BAB48637.1 probable endopeptidase from Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577 probable peptidase (EC 3.4.21.-) (726 aa), FASTA scores: opt: 1126, E(): 0, (40.9% identity in 491 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY369.26 FASTA score: (33.8% identity in 299 aa overlap).; peptidase	complement(547586..549607)	Mycobacterium tuberculosis H37Rv	886310
NP_214972.1	CDS	Rv0458	NC_000962.2	549675	551198	D	Rv0458, (MTV038.02), len: 507 aa. Probable aldehyde dehydrogenase (EC 1.2.1.3), highly similar to many, closest to P46369|THCA_RHOER EPTC-INDUCIBLE ALDEHYDE DEHYDROGENASE from Rhodococcus erythropolis (506 aa), FASTA scores: opt: 2767, E(): 0, (79.7% identity in 507 aa overlap); AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (505 aa), FASTA scores: opt: 2563, E(): 0, (75.4% identity in 492 aa overlap); Q9RJZ6|DHAL_STRCO PROBABLE ALDEHYDE DEHYDROGENASE from Streptomyces coelicolor (507 aa). Also similar to other semialdehyde dehydrogenases in Mycobacterium tuberculosis e.g. Rv0768, Rv2858c. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. TBparse score is 0.866.; aldehyde dehydrogenase	549675..551198	Mycobacterium tuberculosis H37Rv	886306
NP_214973.1	CDS	Rv0459	NC_000962.2	551198	551689	D	Rv0459, (MTV038.03), len: 163 aa. Conserved hypothetical protein, highly similar to other hypothetical proteins. Note that highly similar to products of unidentified ORFs in Xanthobacter autotrophicus, AF029733_2 (139 aa), and Rhodococcus erythropolis, REREUTP BC_1 (186 aa). Like MTV038.03, these ORF's are linked to aldehyde dehydrogenase genes. FASTA scores: AF0297|AF029733_2 (139 aa), opt: 439, E(): 6.2e-24, (50.0% identity in 126 aa overlap); and L24492|REREUTPBC_1 (186 aa), opt: 347, E(): 2.1e-17, (52.7% identity in 169 aa overlap). N-terminus also highly similar to AAA63041.1|U15183 ethanolamine permease (eutP) match from Mycobacterium leprae (53 aa). TBparse score is 0.894.; hypothetical protein	551198..551689	Mycobacterium tuberculosis H37Rv	886372
NP_214974.1	CDS	Rv0460	NC_000962.2	551749	551988	D	Rv0460, (MTV038.04), len: 79 aa. Conserved hydrophobic protein, highly similar AAA63024.1|U15183 hypothetical protein from Mycobacterium leprae (56 aa), FASTA scores: opt: 197, E(): 3.7e-09, (63.8% identity in 47 aa overlap). TBparse score is 0.896.; hypothetical protein	551749..551988	Mycobacterium tuberculosis H37Rv	886304
NP_214975.1	CDS	Rv0461	NC_000962.2	552026	552550	D	Rv0461, (MTV038.05), len: 174 aa (start uncertain). Probable transmembrane protein. TBparse score is 0.917.; hypothetical protein	552026..552550	Mycobacterium tuberculosis H37Rv	886302
NP_214976.1	CDS	lpd	NC_000962.2	552614	554008	D	E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase	552614..554008	Mycobacterium tuberculosis H37Rv	886300
NP_214977.1	CDS	Rv0463	NC_000962.2	554016	554309	D	Rv0463, (MTV038.07), len: 97 aa. Probable conserved transmembrane protein, highly similar to AAA63017.1|U15183 hypothetical protein from Mycobacterium leprae (101 aa), FASTA scores: opt: 364, E(): 4e-21, (57.9% identity in 95 aa overlap). TBparse score is 0.893.; hypothetical protein	554016..554309	Mycobacterium tuberculosis H37Rv	886299
NP_214978.1	CDS	Rv0464c	NC_000962.2	554313	554885	R	Rv0464c, (MTV038.08c), len: 190 aa. Conserved hypothetical protein, highly similar to CAC31982.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (188 aa). Also some similarity with Rv1531|AL022000|MTV045_5|D70820 hypothetical protein from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 9.6e-10, (30.9% identity in 175 aa overlap). TBparse score is 0.925.; hypothetical protein	complement(554313..554885)	Mycobacterium tuberculosis H37Rv	886296
NP_214979.1	CDS	Rv0465c	NC_000962.2	554882	556306	R	Rv0465c, (MTV038.09c), len: 474 aa. Probable transcriptional regulator, highly similar to AC44331.1|AL596102 putative DNA-binding protein from Streptomyces coelicolor (489 aa); and similar to several hypothetical proteins and others transcriptional regulators. Some similarity in N-terminal region (1-100 aa) with repressors e.g. P06153|RPC_BPPH1 IMMUNITY REPRESSOR PROTEIN (144 aa), FASTA scores: opt: 130, E(): 0.084,(27.0% identity in 100 aa overlap). Very similar to Rv1129c|Z95585|MTCY22G8.18c from Mycobacterium tuberculosis (486 aa), FASTA scores: opt: 1475, E(): 0, (47.4% identity in 468 aa overlap). Contains probable helix-turn-helix motif at aa 19-40 (1827, +5.41 SD). TBparse score is 0.896.; transcriptional regulatory protein	complement(554882..556306)	Mycobacterium tuberculosis H37Rv	886320
NP_214980.1	CDS	Rv0466	NC_000962.2	556458	557252	D	Rv0466, (MTV038.10), len: 264 aa. Conserved hypothetical protein, equivalent to CAC31980.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (264 aa). Similar to Rv2001|Z74025|MTCY39.17c HYPOTHETICAL 28.7 KDA PROTEIN from Mycobacterium tuberculosis (250 aa), FASTA scores: opt: 592, E(): 0, (38.0% identity in 263 aa overlap). Some similarity to several THIOESTERASES e.g. Q42561|ATACPTE17_1 ACYL-(ACYL CARRIER PROTEIN) THIOESTER from A. thaliana (362 aa), FASTA scores: E(): 0.0092, (24.4% identity in 197 aa overlap).; hypothetical protein	556458..557252	Mycobacterium tuberculosis H37Rv	886294
YP_177728.1	CDS	icl	NC_000962.2	557527	558813	D	Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase	557527..558813	Mycobacterium tuberculosis H37Rv	886291
NP_214982.1	CDS	fadB2	NC_000962.2	558895	559755	D	converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase	558895..559755	Mycobacterium tuberculosis H37Rv	886288
YP_177729.1	CDS	umaA	NC_000962.2	559888	560748	D	Rv0469, (MTV038.13), len: 286 aa. Possible umaA, mycolic acid synthase (EC 2.-.-.-) (see citations below), highly similar to CAC30854.1|AL583923 methyl mycolic acid synthase 1 from Mycobacterium leprae (286 aa); and CAC31976.1|AL583925 Mycolic acid synthase from Mycobacterium leprae (295 aa), FASTA scores: opt: 1402, E(): 0, (69.6% identity in 286 aa overlap). Also very similar to mycobacterial methyltransferases e.g. U77466|CmaD|MBU77466_1 (286 aa); MTCY20H10.26c|Z92772|MTY20H10_27 (296 aa); highly similar to CFA1_MYCTU|Q11195|U66108|MTU66108_1 cyclopropane-fatty-acyl-phospholipid synthase 1 (287 aa), FASTA scores: opt: 1360, E(): 0, (67.8% identity in 286 aa overlap) (see citation below); and very similar also to methoxy mycolic acid synthase 1 from Mycobacterium tuberculosis e.g. MTU66108_1 (286 aa). TBparse score is 0.944. Note that previously known as umaA1.; umaA1; mycolic acid synthase	559888..560748	Mycobacterium tuberculosis H37Rv	886286
YP_177730.1	CDS	pcaA	NC_000962.2	560848	561711	R	Rv0470c, (MTV038.14), len: 287 aa. pcaA (previously known as umaA2), mycolic acid synthase (cyclopropane synthase) (EC 2.-.-.-) (see citations below), equivalent to CAC31976.1|AL583925 Mycolic acid synthase from Mycobacterium leprae (295 aa); and highly similar to S72886|B2168_F3_130|467038|AAA17222.1|U00018 hypothetical protein from Mycobacterium leprae (308 aa); Q11195|CFA1_MYCTU CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1) (287 aa) (see Glickman et al., 2000); U27357|MTU27357_1 cyclopropane mycolic acid synthase from Mycobacterium tuberculosis (287 aa), FASTA scores: opt: 1415, E(): 0, (72.8% identity in 287 aa overlap); and related enzymes e.g. MTCY20H10.25c|Z92772|MTY20H10_26 (287 aa), FASTA scores: opt: 1387, E(): 0, (72.5% identity in 287 aa overlap). TBparse score is 0.893.; umaA2; mycolic acid synthase PcaA	complement(560848..561711)	Mycobacterium tuberculosis H37Rv	886284
YP_177622.1	CDS	Rv0470A	NC_000962.2	561854	562294	R	Rv0470A, len: 146 aa. Hypothetical unknown protein. GC plot suggests CDS for Cys-rich protein, could possibly be continuation of Rv0471c but no frameshift found to allow this. Sequence same in Mycobacterium bovis and Mycobacterium tuberculosis strain CDC1551. Weak hits to Cys-rich region (aa 258-314) of D63395|D63395_1 mRNA for NOTCH4 from Homo sapiens (1095 aa), FASTA scores: opt: 132, E(): 1.1, (39.35% identity in 61 aa overlap).; hypothetical protein	complement(561854..562294)	Mycobacterium tuberculosis H37Rv	3205059
NP_214985.1	CDS	Rv0471c	NC_000962.2	562225	562713	R	Rv0471c, (MTV038.15c), len: 162 aa. Hypothetical unknown protein. TBparse score is 0.937.; hypothetical protein	complement(562225..562713)	Mycobacterium tuberculosis H37Rv	886280
NP_214986.1	CDS	Rv0472c	NC_000962.2	562723	563427	R	Rv0472c, (MTV038.16c), len: 234 aa. Probable regulatory protein, possibly tetR family, equivalent to CAC31974.1|AL583925 possible TetR-family transcriptional regulator from Mycobacterium leprae (233 aa). Also similar to CAC01492.1|AL391017 putative transcriptional regulatory protein from Streptomyces coelicolor (218 aa); and CAC01371.1|AL390975 putative tetR-family transcriptional regulator from Streptomyces coelicolor (228 aa). Also similar to AL0212|MTV012_65 from Mycobacterium tuberculosis (246 aa), FASTA scores: opt: 327, E(): 1.8e-15, (31.0% identity in 232 aa overlap); and Z95120|MTCY07D11.18c (228 aa), FASTA scores: opt: 190, E(): 4.4e-06, (23.1% identity in 186 aa overlap). Contains probable helix-turn-helix doimain at aa 45-66 (Score 1429, +4.05 SD). TBparse score is 0.898.; TetR family transcriptional regulator	complement(562723..563427)	Mycobacterium tuberculosis H37Rv	886308
NP_214987.1	CDS	Rv0473	NC_000962.2	563564	564934	D	Rv0473, (MTV038.17), len: 456 aa. Possible conserved transmembrane protein, showing some similarity to hypothetical proteins e.g. NP_102800.1|14021975|BAB48586.1|AP002996 hypothetical protein from Mesorhizobium loti (431 aa); P39385|YJIN_ECOLI|YJIN|B4336 HYPOTHETICAL 48.2 kDa PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Escherichia coli strain K12 (426 aa), FASTA scores: opt: 396, E(): 9.8e-19, (31.8 % identity in 424 aa overlap); etc. TBparse score is 0.899.; transmembrane protein	563564..564934	Mycobacterium tuberculosis H37Rv	886279
NP_214988.1	CDS	Rv0474	NC_000962.2	565021	565443	D	Rv0474, (MTV038.18), len: 140 aa. Probable transcriptional regulator, highly similar to others e.g. CAC04034.1|AL391406 putative DNA-binding protein from Streptomyces coelicolor (141 aa); N-terminus of NP_104173.1|14023352|BAB49959.1|AP003000 transcriptional regulator from Mesorhizobium loti (219 aa); N-terminus of A83618|PA0225 probable transcription regulator from Pseudomonas aeruginosa (179 aa); SINR_BACSU|P06533 sinr protein from Bacillus subtilis (111 aa), FASTA scores: opt: 147, E(): 8.9e-06, (30.6% identity in 111 aa overlap). Also similar to other hypothetical proteins e.g. X66407|RRPHAS_1|ORF1 from Rhodococcus ruber (171 aa), FASTA scores: opt: 280, E(): 4.8e-12, (43.6% identity in 117 aa overlap). Also similar to Rv2745c from Mycobacterium tuberculosis. Contains probable helix-turn-helix domain at aa 35-56 (Score 1709, +5.01 SD). TBparse score is 0.903.; transcriptional regulatory protein	565021..565443	Mycobacterium tuberculosis H37Rv	886276
NP_214989.1	CDS	hbhA	NC_000962.2	565797	566396	D	Rv0475, hbhA (MTCY20G9.01), len: 199 aa. hbhA, iron-regulated heparin-binding hemagglutinin (see citations below), equivalent to CAC31971.1|AL583925 possible hemagglutinin from Mycobacterium leprae (188 aa). Contains possible N-terminal signal sequence and K-A-rich region at C-terminus: SUBCELLULAR LOCATION: SURFACE ASSOCIATED.; iron-regulated heparin binding hemagglutinin hbhA (adhesin)	565797..566396	Mycobacterium tuberculosis H37Rv	886272
NP_214990.1	CDS	Rv0476	NC_000962.2	566508	566771	D	Rv0476, (MTCY20G9.02), len: 87 aa. Possible conserved transmembrane protein, equivalent to CAC31970.1|AL583925 conserved membrane protein from Mycobacterium leprae (95 aa). Also highly similar to CAC04036.1|AL391406 putative membrane protein from Streptomyces coelicolor (113 aa). Contains PS00606 Beta-ketoacyl synthases active site.; transmembrane protein	566508..566771	Mycobacterium tuberculosis H37Rv	886282
NP_214991.1	CDS	Rv0477	NC_000962.2	566776	567222	D	Rv0477, (MTCY20G9.03), len: 148 aa. Possible conserved secreted protein, equivalent to CAC31969.1|AL583925 hypothetical protein from Mycobacterium leprae (123 aa). Also similar to G83406|PA1914 conserved hypothetical protein from Pseudomonas aeruginosa (408 aa). Contains possible N-terminal signal sequence.; hypothetical protein	566776..567222	Mycobacterium tuberculosis H37Rv	886273
NP_214992.1	CDS	deoC	NC_000962.2	567222	567896	D	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase	567222..567896	Mycobacterium tuberculosis H37Rv	888425
NP_214993.1	CDS	Rv0479c	NC_000962.2	567921	568967	R	Rv0479c, (MTCY20G9.04c), len: 348 aa. Probable conserved membrane protein, equivalent to CAC31967.1|AL583925 possible secreted protein from Mycobacterium leprae (254 aa); and C-terminus highly similar to AAF74996.1|AF143402_1|AF143402 putative multicopper oxidase from Mycobacterium avium (149 aa). Contains hydrophobic domain in centre of protein.; hypothetical protein	complement(567921..568967)	Mycobacterium tuberculosis H37Rv	885535
NP_214994.2	CDS	Rv0480c	NC_000962.2	568964	569806	R	Rv0480c, (MTCY20G9.06c), len: 280 aa. Possible amidohydrolase (EC 3.-.-.-), highly similar to NP_302587.1|NC_002677|CAC31966.1|AL583925 putative hydrolase from Mycobacterium leprae (271 aa). Also similar to other hydrolases and hypothetical proteins e.g. NP_601985.1|NC_003450 Predicted amidohydrolase from Corynebacterium glutamicum (266 aa); NP_459623.1|NC_003197 putative hydrolase from Salmonella typhimurium LT2 (262 aa); AL096822|SCGD3_8|NP_627996.1|NC_003888 probable hydrolase from Streptomyces coelicolor (264 aa), FASTA scores: opt: 368, E(): 6.1e-15, (34.2% identity in 272 aa overlap); YAUB_SCHPO|Q10166 hypothetical 35.7 kDa protein c26a3.11 from S. pombe (322 aa), FASTA scores: opt: 338, E():1.4e-13, (30.3% identity in 277 aa overlap); etc. Start changed since first submission (-60 aa).; amidohydrolase	complement(568964..569806)	Mycobacterium tuberculosis H37Rv	887163
NP_214995.1	CDS	Rv0481c	NC_000962.2	569988	570512	R	Rv0481c, (MTCY20G9.07c), len: 174 aa. Hypothetical unknown protein.; hypothetical protein	complement(569988..570512)	Mycobacterium tuberculosis H37Rv	887161
NP_214996.1	CDS	murB	NC_000962.2	570539	571648	D	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase	570539..571648	Mycobacterium tuberculosis H37Rv	887169
NP_214997.1	CDS	lprQ	NC_000962.2	571710	573065	D	Rv0483, (MTCY20G9.09), len: 451 aa. Probable lprQ, conserved lipoprotein, equivalent to CAC31963.1|AL583925|ML2446 possible lipoprotein from Mycobacterium leprae (441 aa); appears longer than ML2446, so start may be further downstream. Shows also similarity with MLCL383_24|O07707 HYPOTHETICAL 43.6 kDa PROTEIN from Mycobacterium leprae; and to Q49706|B1496_F2_81 (271 aa). Similar to others lipoproteins from other organisms. Also similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv0116c, Rv0192, Rv1433, Rv2518c. Contains potential N-terminal signal sequence and appropriately positioned PS00013 prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LprQ	571710..573065	Mycobacterium tuberculosis H37Rv	887167
NP_214998.1	CDS	Rv0484c	NC_000962.2	573046	573801	R	Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase (EC 1.-.-.-), highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa); YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa), FASTA scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa overlap); etc. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. STRONG SIMILARITY, TO BACTERIAL YDFG HOMOLOGS.; short-chain type oxidoreductase	complement(573046..573801)	Mycobacterium tuberculosis H37Rv	887158
NP_214999.1	CDS	Rv0485	NC_000962.2	573984	575300	D	Rv0485, (MTCY20G9.11), len: 438 aa. Possible transcriptional repressor, member of the NAGC/XYLR repressor FAMILY; similar to several e.g. D87820_3|O32446|D82254 NAGC N-acetylglucosamine repressor from Vibrio cholerae (404 aa), FASTA scores: opt: 378, E(): 1.2e-17, (26.9% identity in 350 aa overlap); NAGC_ECOLI|P15301 N-acetylglucosamine repressor from Escherichia coli (406 aa), FASTA scores: opt: 305, E(): 1.8e-12, (21.8% identity in 357 aa overlap); etc.; transcriptional regulatory protein	573984..575300	Mycobacterium tuberculosis H37Rv	887170
NP_215000.1	CDS	Rv0486	NC_000962.2	575348	576790	D	Rv0486, (MTCY20G9.12), len: 480 aa. Mannosyltransferase (EC 2.4.1.-) (see citations below), highly similar to P54138|Y486_MYCLE|ML2443 possible glycosyl transferase from Mycobacterium leprae (428 aa); and S72892|B2168_C2_201 probable hexosyltransferase (EC 2.4.1.-) from Mycobacterium leprae (409 aa), FASTA scores: opt: 2375, E(): 0, (86.4% identity in 413 aa overlap). Also highly similar to CAC04040.1|AL391406 putative transferase from Streptomyces coelicolor (496 aa); and similar to various transferases e.g. NP_437172.1|NC_003078 putative membrane-anchored glycosyltransferase protein from Sinorhizobium meliloti (416 aa); O26550|U67601_1 LPS BIOSYNTHESIS RELATED PROTEIN from Methanococcus jannaschii (411 aa), FASTA score: (25.3% identity in 387 aa overlap); etc. Also similar to CAC87824.1|AJ316594 putative sucrose-phosphate synthase from Nostoc punctiforme (422 aa). Contains PS00039 DEAD-box subfamily ATP-dependent helicases signature.; mannosyltransferase	575348..576790	Mycobacterium tuberculosis H37Rv	887160
NP_215001.1	CDS	Rv0487	NC_000962.2	576787	577338	D	Rv0487, (MTCY20G9.13), len: 183 aa. Conserved hypothetical protein, highly similar to P54139|Y487_MYCLE|U00018_38|ML2442 HYPOTHETICAL 20.8 KDA PROTEIN from Mycobacterium leprae (184 aa), FASTA scores: opt: 760, E(): 2.4 e-34, (73.0% identity in 159 aa overlap). Also highly similar to CAC04041.1|AL391406 conserved hypothetical protein from Streptomyces coelicolor (168 aa).; hypothetical protein	576787..577338	Mycobacterium tuberculosis H37Rv	887162
NP_215002.1	CDS	Rv0488	NC_000962.2	577664	578269	D	Rv0488, (MTCY20G9.14), len: 201 aa. Probable conserved integral membrane protein, LysE family possibly involved in transport of Lysine, similar to others and conserved hypothetical proteins e.g. AB93746.1|AL357613 putative membrane transport protein from Streptomyces coelicolor (204 aa); D83100|PA4365 probable transporter from Pseudomonas aeruginosa (200 aa); YGGA_ECOLI|P11667 hypothetical 21.7 kDa protein from Escherichia coli (197 aa), FASTA scores: opt: 382, E(): 1.1e-19, (39.1% identity in 179 aa overlap); CGLYSEG_2 C|P94633 LYSINE EXPORTER PROTEIN (236 aa), FASTA scores: E(): 2.3e-07, (33.3% identity in 219 aa overlap). Also similar to Rv1986 from Mycobacterium tuberculosis.; integral membrane protein	577664..578269	Mycobacterium tuberculosis H37Rv	887171
YP_177731.1	CDS	gpmA	NC_000962.2	578426	579175	D	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase	578426..579175	Mycobacterium tuberculosis H37Rv	887183
NP_215004.1	CDS	senX3	NC_000962.2	579349	580581	D	Rv0490, (MTCY20G9.16), len: 410 aa. Putative senX3, two-component sensor histidine kinase (EC 2.7.3.-), transmembrane protein (see citations below), equivalent to O07129|SEX3_MYCBO SENSOR-LIKE HISTIDINE KINASE SENX3 from Mycobacterium bovis BCG (410 aa), FASTA scores: E(): 0, (99.5% identity in 410 aa overlap); and highly similar to P54883|SEX3_MYCLE|SENX3 SENSOR-LIKE HISTIDINE KINASE from Mycobacterium leprae (443 aa), FASTA score: (83.8% identity in 408 aa overlap). Also highly similar, except in N-terminus, to CAC31957.1|AL583925 probable two-component system sensor histidine kinase from Mycobacterium leprae (441 aa). Also highly similar to sensor kinase proteins from other organisms e.g. CAB77323.1|AL160331 putative sensor kinase protein from Streptomyces coelicolor (426 aa).; putative two component sensor histidine kinase SENX3	579349..580581	Mycobacterium tuberculosis H37Rv	887185
NP_215005.1	CDS	regX3	NC_000962.2	580809	581492	D	Rv0491, (MTCY20G9.17), len: 227 aa. regX3, response regulator protein (sensory transduction protein) (see citations below), equivalent to O07130|RGX3_MYCBO|REGX3 SENSORY TRANSDUCTION PROTEIN from Mycobacterium bovis BCG (227 aa); AAG09797.1|AF258346_2|AF258346|REGX3 response regulator from Mycobacterium smegmatis (228 aa); equivalent to P54884|RGX3_MYCLE|REGX3 SENSORY TRANSDUCTION PROTEIN from Mycobacterium leprae (198 aa), FASTA scores : E(): 0, (95.4% identity in 197 aa overlap). Also highly similar to other response regulators e.g. AAG43239.1|AF123314_2 |AF123314 putative response regulator from Corynebacterium glutamicum (232 aa).; two component sensory transduction protein RegX3	580809..581492	Mycobacterium tuberculosis H37Rv	887195
NP_215006.2	CDS	Rv0492c	NC_000962.2	581489	583378	R	Rv0492c, (MT0511/MT0512, MTCY20G9.18c), len: 629 aa. Probable oxidoreductase GMC type (EC 1.-.-.-), similar to others except in N-terminus e.g. P55582|AE000087_5|Y4NJ_RHISN HYPOTHETICAL GMC-TYPE OXIDOREDUCTASE from Rhizobium sp. (505 aa), FASTA scores: opt: 873, E():0, (34.3% identity in 502 aa overlap); YTH2_RHOER|P46371 HYPOTHETICAL 53.0 kDa GMC-TYPE OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa), FASTA score: (25.7% identity in 521 aa overlap); YTH2_RHOSO|P46371 hypothetical 53.0 kDa gmc-type oxidoreductase from Rhodococcus erythropolis (493 aa), FASTA score: (25.7% identity in 521 aa overlap); NP_085596.1|NC_002679 probable oxidoreductase from Mesorhizobium loti (507 aa); NP_285451.1|NC_001264 GMC oxidoreductase from Deinococcus radiodurans (722 aa); NP_249055.1|NC_002516 probable oxidoreductase from Pseudomonas aeruginosa (531 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, and PS00624 GMC oxidoreductases signature 2. BELONGS TO THE GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD (BY SIMILARITY). Note that start changed since first submission (previously 684 aa).; oxidoreductase GMC-type	complement(581489..583378)	Mycobacterium tuberculosis H37Rv	887199
YP_177623.1	CDS	Rv0492A	NC_000962.2	583375	583704	R	Rv0492A, len: 109 aa. Hypothetical unknown protein. GC plot suggests CDS.; hypothetical protein	complement(583375..583704)	Mycobacterium tuberculosis H37Rv	3205069
NP_215007.1	CDS	Rv0493c	NC_000962.2	583701	584690	R	Rv0493c, (MTCY20G9.19), len: 329 aa. Conserved hypothetical protein, showing some similarity to U00018_33|B2168_F2_93 from Mycobacterium leprae (167 aa), FASTA scores: opt: 166, E(): 0.00077, (35.9% identity in 131 aa overlap).; hypothetical protein	complement(583701..584690)	Mycobacterium tuberculosis H37Rv	887200
NP_215008.2	CDS	Rv0494	NC_000962.2	584695	585423	D	Rv0494, (MTCY20G9.20), len: 242 aa. Probable transcriptional regulator, GntR family, with C-terminal part highly similar to S72893|B2168_C2_205 hypothetical protein from Mycobacterium leprae (105 aa). Also similar to other transcription regulators e.g. PDHR_ECOLI|P06957 pyruvate dehydrogenase complex repressor PDHR or GENA from Escherichia coli (254 aa), FASTA scores: opt: 284, E(): 1.2e-11, (32.6% identity in 224 aa overlap); etc. Contains PS00043 Bacterial regulatory proteins, gntR family signature, and probable helix-turn helix motif from aa 50-71 (Score 1229, +3.37 SD).; GntR family transcriptional regulator	584695..585423	Mycobacterium tuberculosis H37Rv	887166
NP_215009.1	CDS	Rv0495c	NC_000962.2	585424	586314	R	Rv0495c, (MTCY20G9.21c), len: 296 aa. Conserved hypothetical protein, highly similar to S72915|B2168_F1_37 hypothetical protein from Mycobacterium leprae (323 aa), FASTA scores: opt: 1615, E(): 0, (82.7% identity in 271 aa overlap); and P54579|Y495_MYCLE|ML243|13094009|CAC31952.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (277 aa). Also highly similar to Q9X8H2|Y716_STRCO|SCE7.16 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (271 aa).; hypothetical protein	complement(585424..586314)	Mycobacterium tuberculosis H37Rv	887198
NP_215010.1	CDS	Rv0496	NC_000962.2	586394	587380	D	Rv0496, (MTCY20G9.22), len: 328 aa. Conserved hypothetical protein, highly similar to S72894|467046|AAA17230.1|U00018 exopolyphosphatase (EC 3.6.1.11) ppx from Mycobacterium leprae (406 aa), FASTA scores: opt: 1902, E(): 0, (86.6% identity in 343 aa overlap); and P54882|Y496_MYCLE|ML2434|13094008|CAC31951.1|AL583925 HYPOTHETICAL 36.2 KDA PROTEIN from Mycobacterium leprae (339 aa). Also highly similar to hypothetical proteins and exopolyphosphatases e.g. Q9X8H1|Y715_STRCO|SCE7.15c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (309 aa). C-terminal region similar to CGU31224_1|Q46054 protein similar to ppx gene product of Mycobacterium leprae from Cornybacterium glutamicum (140 aa), FASTA scores: opt: 615, E(): 2.7e-33, (70.9% identity in 134 aa overlap).; hypothetical protein	586394..587380	Mycobacterium tuberculosis H37Rv	887234
NP_215011.1	CDS	Rv0497	NC_000962.2	587377	588309	D	Rv0497, (MTCY20G9.23), len: 310 aa. Probable conserved transmembrane protein, equivalent (but shorter in C-terminus) to P54580|Y497_MYCLE|ML2433 HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium leprae (355 aa). N-terminus highly similar to S72922|B2168_C1_166|467074 hypothetical protein from Mycobacterium leprae (118 aa), FASTA scores: opt: 350, E(): 1.4e-12, (57.9% identity in 114 aa overlap); and hydrophobic C-terminus, highly similar to S72895|B2168_C2_209|467047 hypothetical protein from Mycobacterium leprae (241 aa), FASTA scores: opt: 473, E(): 8e-19, (53.9% identity in 241 aa).; transmembrane protein	587377..588309	Mycobacterium tuberculosis H37Rv	887240
NP_215012.1	CDS	Rv0498	NC_000962.2	588325	589167	D	Rv0498, (MTCY20G9.24), len: 280 aa. Conserved hypothetical protein, highly similar to P54581|Y498_MYCLE|ML2432 HYPOTHETICAL 30.5 KDA PROTEIN from Mycobacterium leprae (280 aa); and S72896|B2168_C2_210 hypothetical protein from Mycobacterium leprae (244 aa), FASTA scores: opt: 1486, E():0, (89.3% identity in 244 aa overlap). Also similar to Q9X8H0|Y714_STRCO|SCE7.14c HYPOTHETICAL PROTEIN from Streptomyces coelicolor.; hypothetical protein	588325..589167	Mycobacterium tuberculosis H37Rv	887238
NP_215013.1	CDS	Rv0499	NC_000962.2	589183	590058	D	Rv0499, (MTCY20G9.25), len: 291 aa. Conserved hypothetical protein, showing some similarity to AL031184|SC2A11_16|T34762 hypothetical protein from Streptomyces coelicolor (340 aa), FASTA scores: opt: 240, E(): 1.8e-07, (28.9% identity in 270 aa overlap).; hypothetical protein	589183..590058	Mycobacterium tuberculosis H37Rv	887243
NP_215014.1	CDS	proC	NC_000962.2	590083	590970	D	catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase	590083..590970	Mycobacterium tuberculosis H37Rv	887256
YP_177624.1	CDS	Rv0500A	NC_000962.2	591111	591347	D	Rv0500A, len: 78 aa. Conserved hypothetical protein, similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. U00018_25 from Mycobacterium leprae cosmid B2168 (86 aa), FASTA scores: opt: 428, E(): 1.3e-27, (82.6% identity in 86 aa overlap); AL079345|SCE68_26 from Streptomyces coelicolor cosmid E6 (70 aa), FASTA scores: opt: 252, E(): 1.2 e-13, (72.2 identity in 54 aa overlap).; hypothetical protein	591111..591347	Mycobacterium tuberculosis H37Rv	3205035
YP_177625.1	CDS	Rv0500B	NC_000962.2	591475	591576	D	Rv0500B, len: 33 aa. Conserved hypothetical protein. Basic protein 18 of the 33 aa are Arg or Lys, with strong similarity to AL079345|SCE68_25 protein from Streptomyces coelicolor cosmid E6 (32 aa), FASTA scores: opt: 176, E(): 1e-06, (93.1% identity in 29 aa overlap). Same gene arrangement in both actinomycetes.; hypothetical protein	591475..591576	Mycobacterium tuberculosis H37Rv	3205036
NP_215050.2	CDS	galE2	NC_000962.2	591654	592784	D	Rv0501, (MTCY20G9.28), len: 376 aa. Possible galE2, UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar (except in N-terminus) to CAC31944.1|AL583925 possible glucose epimerase/dehydratase from Mycobacterium leprae (364 aa). N-terminus highly similar to S72923|B2168_C1_174|467075|AAA17259.1|U00018 hypothetical protein from Mycobacterium leprae (180 aa), FASTA scores: opt: 934, E(): 0, (89.6% identity in 164 aa overlap); and C-terminus highly similar to S72898|467050|AAA17234.1|U00018 hypothetical protein from Mycobacterium leprae (168 aa), FASTA scores: opt: 928, E(): 0, (82.7% identity in 168 aa overlap). Also highly similar to T36274|5123671|CAB45360.1|AL079345 probable epimerase from Streptomyces coelicolor (353 aa); and similar in part to other epimerases e.g. GALE_ECOLI|P09147 UDP-glucose 4-epimerase from Escherichia coli (338 aa), FASTA scores: opt: 241, E(): 6.7e-09, (28.2% identity in 294 aa overlap); etc. BELONGS TO THE SUGAR EPIMERASE FAMILY. COFACTOR: NAD. Note that previously known as galE1.; galE1; UDP-glucose 4-epimerase	591654..592784	Mycobacterium tuberculosis H37Rv	887228
NP_215016.1	CDS	Rv0502	NC_000962.2	592791	593867	D	Rv0502, (MTCY20G9.29), len: 358 aa. Conserved hypothetical protein, equivalent to P54878|Y502_MYCLE|ML2427 HYPOTHETICAL 40.5 KDA PROTEIN from Mycobacterium leprae (367 aa), FASTA scores: opt: 2042, E(): 0, (84.1% identity in 365 aa overlap). Also similar to T36273|SCE68.23c hypothetical protein from Streptomyces coelicolor (355 aa). C-terminal similar to AL021529|SC10A5_4|T34572 hypothetical protein from Streptomyces coelicolor (295 aa), FASTA score: (57.8% identity in 263 aa overlap); and to hypothetical proteins from Mycobacterium tuberculosis Rv1920|G70808 (287 aa); and Rv1428c|G70914 (275 aa).; hypothetical protein	592791..593867	Mycobacterium tuberculosis H37Rv	887260
NP_215017.1	CDS	cmaA2	NC_000962.2	593871	594779	R	Rv0503c, (MTCY20G9.30c), len: 302 aa. cmaA2 (alternate gene name: cma2), cyclopropane-fatty-acyl-phospholipid synthase 2 (mycolic acid trans-cyclopropane synthetase) (EC 2.1.1.79) (see citations below). Note that this protein has 302 aa and not 322 aa: we have chosen a different initiation codon on the basis of homology). Equivalent to S72886|B2168_F3_130 hypothetical protein from Mycobacterium leprae (308 aa), FASTA score: (78.9% identity in 303 aa overlap); and highly similar to other proteins from Mycobacterium leprae. Also similar to other proteins from Mycobacterium tuberculosis and Mycobacterium bovis BCG e.g. MTV038_14|UMAA2|Rv0470c|MTV038.14 PUTATIVE MYCOLIC ACID SYNTHESIS/MODIFICATION PROTEIN (287 aa) (57.2% identity in 297 aa overlap).; cma2; cyclopropane-fatty-acyl-phospholipid synthase 2	complement(593871..594779)	Mycobacterium tuberculosis H37Rv	887264
NP_215018.1	CDS	Rv0504c	NC_000962.2	594802	595302	R	Rv0504c, (MTCY20G9.31c), len: 166 aa. Conserved hypothetical protein, equivalent to P54879|Y504_MYCLE|ML2425 HYPOTHETICAL 18.7 KDA PROTEIN from Mycobacterium leprae (166 aa), FASTA scores: opt: 884, E(): 0, (83.1% identity in 166 aa overlap); and highly similar to other proteins from Mycobacterium leprae. Also highly similar to CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa). Also similar to M. tuberculosis hypothetical proteins Rv0635|H70612 (158 aa); and Rv0637|B70613 (166 aa).; hypothetical protein	complement(594802..595302)	Mycobacterium tuberculosis H37Rv	887268
YP_177732.1	CDS	serB1	NC_000962.2	595464	596585	R	Rv0505c, (MTCY20G9.32c), len: 373 aa. Possible serB1, phosphoserine phosphatase (EC 3.1.3.3), equivalent (but longer 70 aa in N-terminus) to S72914|serB phosphoserine phosphatase from Mycobacterium leprae (300 aa), FASTA scores: opt: 1570, E(): 0, (83.0% identity in 306 aa overlap). C-terminus highly similar to CAB55344.1|AJ010584 phosphoserine phosphatase from Streptomyces coelicolor (266 aa). Low similarity to SERB_ECOLI|P06862 phosphoserine phosphatase from Escherichia coli strains K12 and O157:H7 (322 aa), FASTA scores: opt: 148, E(): 0.043, (24.0% identity in 150 aa overlap). C-terminus is also similar to O33611|AB004855_1|IMD_STRCN PROTEIN INVOLVED IN INHIBITION OF MORPHOLOGICAL DIFFERENTIATION from Streptomyces cyaneus (277 aa), FASTA score: (37.7% identity in 252 aa overlap). SEEMS TO BELONG TO THE SERB FAMILY. Note that previously known as serB.; serB; phosphoserine phosphatase	complement(595464..596585)	Mycobacterium tuberculosis H37Rv	887270
NP_215020.1	CDS	mmpS2	NC_000962.2	596759	597202	D	Rv0506, (MTCY20G9.33), len: 147 aa. Probable mmpS2, conserved membrane protein (see citation below), highly similar to other Mycobacterial proteins e.g. C-terminus of AAD44232.1|AF143772_38|AF143772|TmtpA from Mycobacterium avium (221 aa); P54880|MMS4_MYCLE|MMPS4 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 392, E(): 1.3e-20, (43.7% identity in 151 aa overlap); and the PUTATIVE MEMBRANE PROTEINS from Mycobacterium tuberculosis MTV040_5, MTCY4D9_16, MTV037_15. BELONGS TO THE MMPS FAMILY.; membrane protein	596759..597202	Mycobacterium tuberculosis H37Rv	887279
NP_215021.1	CDS	mmpL2	NC_000962.2	597199	600105	D	Rv0507, (MTCY20G9.34), len: 968 aa. Probable mmpL2, conserved transmembrane transport protein (see citations below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCLE from Mycobacterium leprae (959 aa), FASTA scores: opt: 3699, E(): 0, (58.3% identity in 940 aa overlap); and the Mycobacterium tuberculosis proteins MTV037_14, MTV040_4, MTCY98_8, MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19, etc. Also similar to STMACTII_3|SC10A5_9 from Streptomyces coelicolor; and BSUB0|004_12 from Bacillus subtilis. C-terminal half similar to Q50086|U1740AB from Mycobacterium leprae (386 aa), FASTA scores: opt: 1526, E(): 0, (61.5% identity in 371 aa overlap). BELONGS TO THE MMPL FAMILY.; transmembrane transport protein MmpL2	597199..600105	Mycobacterium tuberculosis H37Rv	887248
NP_215022.1	CDS	Rv0508	NC_000962.2	600098	600391	D	Rv0508, (MTCY20G9.35), len: 97 aa. Conserved hypothetical protein, showing similarity with T36269|5123666|CAB45355.1|AL079345 probable redoxin from Streptomyces coelicolor (101 aa), FASTA scores: opt: 160, E(): 3.4e-05, (33.3% identity in 75 aa overlap); and E81943|NMA0966 probable thioredoxin from Neisseria meningitidis group A strain Z2491 (77 aa).; hypothetical protein	600098..600391	Mycobacterium tuberculosis H37Rv	887301
NP_215023.1	CDS	hemA	NC_000962.2	600441	601847	D	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase	600441..601847	Mycobacterium tuberculosis H37Rv	887292
NP_215024.1	CDS	hemC	NC_000962.2	601857	602786	D	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase	601857..602786	Mycobacterium tuberculosis H37Rv	887306
YP_177733.1	CDS	hemD	NC_000962.2	602819	604516	D	Rv0511, (MTCY21C8.02), len: 565 aa. Probable hemD (alternate gene name: cysG), uroporphyrin-III C-methyltransferase (EC 2.1.1.107), highly similar to others e.g. CAC31936.1|AL583925 possible uroporphyrin-III C-methyltransferase from Mycobacterium leprae (563 aa); and S72909|CYSG from Mycobacterium leprae (472 aa), FASTA scores: opt: 1946, E(): 0, (83.3% identity in 472 aa overlap); T36265|5123662|CAB45351.1|AL079345 probable uroporphyrin-III C-methyltransferase from Streptomyces coelicolor (565 aa); and similar to others e.g. AAK00606.1|AF221100_3|AF221100 from Selenomonas ruminantium subsp. ruminantium (505 aa); etc. Also similar to Rv2071c and Rv2847c from Mycobacterium tuberculosis. Note that previously known as cysG.; cysG; uroporphyrin-III C-methyltransferase HemD	602819..604516	Mycobacterium tuberculosis H37Rv	887280
NP_215026.1	CDS	hemB	NC_000962.2	604602	605591	D	catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase	604602..605591	Mycobacterium tuberculosis H37Rv	887312
NP_215027.1	CDS	Rv0513	NC_000962.2	605604	606152	D	Rv0513, (MTCY20G10.03), len: 182 aa. Possible conserved transmembrane protein, with its N-terminus highly similar to S72925|B2168_C1_182 hypothetical protein from Mycobacterium leprae (103 aa), FASTA scores: opt: 217, E(): 8.2e-14, (45.3 % identity in 106 aa overlap).; transmembrane protein	605604..606152	Mycobacterium tuberculosis H37Rv	887307
NP_215028.1	CDS	Rv0514	NC_000962.2	606149	606448	D	Rv0514, (MTCY20G10.04), len: 99 aa. Possible transmembrane protein.; transmembrane protein	606149..606448	Mycobacterium tuberculosis H37Rv	887319
NP_215029.1	CDS	Rv0515	NC_000962.2	606551	608062	D	Rv0515, (MTCY20G10.05), len: 503 aa. Part of M. tuberculosis 13E12 repeat family. Almost identical to Rv0336 (99.8% identity in 503 aa overlap), possibly due to a recent gene duplication. Also similar to other M. tuberculosis hypothetical 13E12 repeat proteins e.g. Rv1148c, Rv1945, etc.; 13E12 repeat family protein	606551..608062	Mycobacterium tuberculosis H37Rv	887322
NP_215030.1	CDS	Rv0516c	NC_000962.2	608059	608535	R	Rv0516c, (MTCY20G10.06c), len: 158 aa. Conserved hypothetical protein, showing some similarity to Rv1365c|MTCY02B10_29 from Mycobacterium tuberculosis (128 aa), FASTA scores: E(): 0.0012, (27.4% identity in 124 aa overlap).; hypothetical protein	complement(608059..608535)	Mycobacterium tuberculosis H37Rv	887324
NP_215031.1	CDS	Rv0517	NC_000962.2	608746	610056	D	Rv0517, (MTCY20G10.07), len: 436 aa. Possible acyltransferase (EC 2.3.1.-), integral membrane protein, equivalent (but longer 26 aa in N-terminus) to AAK44761.1|AE006954 putative acyltransferase from Mycobacterium tuberculosis strain CDC1551 (410 aa). Also similar to many acyltransferases e.g. MDMB_STRMY|Q00718 from Streptomyces mycarofaciens (387 aa), FASTA scores: opt: 200, E(): 1.1e-08, (28.2% identity in 394 aa overlap). And similar to Rv0111, Rv0228, Rv1254, Rv1565c from Mycobacterium tuberculosis.; membrane acyltransferase	608746..610056	Mycobacterium tuberculosis H37Rv	887323
NP_215032.1	CDS	Rv0518	NC_000962.2	610188	610883	D	Rv0518, (MTCY20G10.08), len: 231 aa. Possible exported protein; has hydrophobic N-terminus.; hypothetical protein	610188..610883	Mycobacterium tuberculosis H37Rv	887321
NP_215033.1	CDS	Rv0519c	NC_000962.2	611172	612074	R	Rv0519c, (MTCY20G10.09c), len: 300 aa. Possible conserved membrane protein, with hydrophobic region near N-terminus. Could be a lipase (EC 3.1.-.-). Similar to Rv0774c|MTCY369.19c|A70708 from Mycobacterium tuberculosis (312 aa), FASTA scores: opt: 1092, E(): 0, (57.9% identity in 299 aa overlap). Contains PS00120 Lipases, serine active site.; hypothetical protein	complement(611172..612074)	Mycobacterium tuberculosis H37Rv	887334
NP_215034.1	CDS	Rv0520	NC_000962.2	612255	612605	D	Rv0520, (MTCY20G10.10), len: 116 aa. Possible fragment of methyltransferase (possibly first part) (EC 2.1.1.-), highly similar to part of several methyltransferases e.g. Q43445|U43683 S-ADENOSYL-L-METHIONINE:DELTA24-STEROL-C-METHYLTRANSFERAS E from Glycine max (Soybean)(367 aa), FASTA scores: opt: 190, E(): 2.3e-12, (39.2% identity in 74 aa overlap). Also some similarity to MTCY19G5_5 from Mycobacterium tuberculosis. Possibly continues as Rv0521 but we can find no frameshift to account for this.; hypothetical protein	612255..612605	Mycobacterium tuberculosis H37Rv	887331
YP_177626.1	CDS	Rv0521	NC_000962.2	612598	612903	D	Rv0521, (replaces MTCY20G10.11), len: 101 aa. Possible fragment of methyltransferase (possibly second part) (EC 2.1.1.-), highly similar to C-terminus of several methyltransferases e.g. AAF87203.1|AF216282 sarcosine-dimethylglycine methyltransferase from Halorhodospira halochloris (279 aa). Possibly continuation of Rv0520 but we can find no frameshift to account for this.; hypothetical protein	612598..612903	Mycobacterium tuberculosis H37Rv	3205045
YP_177734.1	CDS	gabP	NC_000962.2	613038	614342	D	Rv0522, (MTCY20G10.12), len: 434 aa. Probable gabP, GABA permease (gamma-aminobutyrate permease), integral membrane protein, highly similar to others e.g. GABP_ECOLI|P25527 gaba permease from Escherichia coli (466 aa), FASTA scores: opt: 1218, E(): 0, (44.3% identity in 424 aa overlap); etc. Also similar to other M. tuberculosis permeases e.g. MTCY13E10.06c FASTA score: (34.4% identity in 407 aa overlap). Contains PS00218 Amino acid permeases signature. Overlaps and extends Rv0523c|MTCY25D10.01 from overlapping cosmid. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY).; GABA permease GabP	613038..614342	Mycobacterium tuberculosis H37Rv	886261
NP_215037.1	CDS	Rv0523c	NC_000962.2	614326	614721	R	Rv0523c, (MTCY25D10.02), len: 131 aa. Conserved hypothetical protein, showing some similarity to M. tuberculosis proteins Rv1598c|MTCY336.06; and Rv1871c|MTCY336_06|O06592 (136 aa), FASTA scores: opt: 197, E(): 5e-08, (38.4% identity in 99 aa overlap).; hypothetical protein	complement(614326..614721)	Mycobacterium tuberculosis H37Rv	887341
NP_215038.1	CDS	hemL	NC_000962.2	614835	616223	D	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase	614835..616223	Mycobacterium tuberculosis H37Rv	887349
NP_215039.1	CDS	Rv0525	NC_000962.2	616223	616831	D	Rv0525, (MTCY25D10.04), len: 202 aa. Conserved hypothetical protein, equivalent to Q49821|B2168_C3_276|S72912 hypothetical protein from Mycobacterium leprae (202 aa), FASTA scores: opt: 1151, E(): 0, (82.5% identity in 200 aa overlap). Also highly similar to CAC08377.1|AL392176 putative phosphoglycerate mutase from Streptomyces coelicolor (233 aa); and similar to SLL0395|Q55734 hypothetical 23.8 kDa protein from SYNECHOCYSTIS SP. (212 aa), FASTA scores: opt: 207, E(): 5.1e-07, (28.2% identity in 195 aa overlap). Also some similarity to Rv2228c|Y019_MYCTU|Q10512|cy427.09 hypothetical 39.2 kDa protein from Mycobacterium tuberculosis (364 aa), FASTA scores: opt: 236, E(): 1.1e-08, (34.3% identity in 198 aa overlap).; hypothetical protein	616223..616831	Mycobacterium tuberculosis H37Rv	887358
NP_215040.1	CDS	Rv0526	NC_000962.2	616846	617496	D	Rv0526, (MTCY25D10.05), len: 216 aa. Possible thioredoxin protein (thiol-disulfide interchange protein) (EC 1.-.-.-), equivalent to Q49816|U2168C|S72901 hypothetical protein from Mycobacterium leprae (216 aa), FASTA scores: opt: 1144, E(): 0, (78.5% identity in 214 aa overlap). C-terminus shows some similarity to C-terminus of thioredoxins e.g. RESA_BACSU|P35160 resa protein from Bacillus subtilis (181 aa), FASTA scores: opt: 200, E(): 7.4e-06, (24.2% identity in 132 aa overlap); etc. Also similar to Mycobacterium tuberculosis thioredoxin-like proteins Rv1470, Rv1471, Rv1677, etc. Contains PS00194 Thioredoxin family active site. SEEMS TO BELONG TO THE THIOREDOXIN FAMILY.; thioredoxin protein	616846..617496	Mycobacterium tuberculosis H37Rv	887339
YP_177735.1	CDS	ccdA	NC_000962.2	617493	618272	D	Rv0527, (MTCY25D10.06), len: 259 aa. Possible ccdA, cytochrome C-type biogenesis protein, integral membrane protein, equivalent to Q49810|B2168_C1_192|S72890 hypothetical protein from Mycobacterium leprae (262 aa), FASTA scores: opt: 1341, E(): 0, (79.0% identity in 262 aa overlap). Also highly similar to others e.g. CAC08380.1 (253 aa); CCDA_BACSU|P45706 cytochrome C-type biogenesis protein from Bacillus subtilis (235 aa), FASTA scores: opt: 307, E(): 7.4e-13, (30.4% identity in 237 aa overlap); etc. SEEMS TO BELONG TO THE DSBD SUBFAMILY. Note that previously known as ccsA.; ccsA; cytochrome C-type biogenesis protein CcdA	617493..618272	Mycobacterium tuberculosis H37Rv	887362
NP_215042.1	CDS	Rv0528	NC_000962.2	618305	619894	D	Rv0528, (MTCY25D10.07), len: 529 aa. Probable conserved transmembrane protein, equivalent (shorter 14 aa in N-terminus) to CAC31926.1|AL583925 conserved membrane protein from Mycobacterium leprae (542 aa). Also highly similar to Q49817|B2168_C2_237|S72902 hypothetical protein from Mycobacterium leprae (364 aa), FASTA scores: opt: 1846, E(): 0, (81.1% identity in 338 aa overlap); and Q49811|B2168_C1_194|S72891 hypothetical protein from Mycobacterium leprae (106 aa), FASTA scores: opt: 506, E(): 3.8e-26, (73.6% identity in 106 aa overlap). Also highly similar to CAC08381.1|AL392176 putative integral membrane protein from Streptomyces coelicolor (574 aa).; transmembrane protein	618305..619894	Mycobacterium tuberculosis H37Rv	887372
NP_215041.2	CDS	ccsA	NC_000962.2	619891	620865	D	Rv0529, (MTCY25D10.08), len: 324 aa. Possible ccsA, cytochrome C-type biogenesis protein, integral membrane protein, equivalent to NP_302558.1|NC_002677|B2168_C3_281 possible cytochrome C biogenesis protein from Mycobacterium leprae (327 aa), FASTA scores: opt: 1779, E(): 0, (82.9% identity in 327 aa overlap). Also highly similar to others e.g. CAC08382.1|AL392176 putative cytochrome biogenesis related protein from Streptomyces coelicolor (380 aa); CCSA_CHLRE|P48269 probable cytochrome c biogenesis protein from Chlamydomonas reinhardtii (353 aa), FASTA scores: opt: 449, E(): 1.3e-23, (34.4% identity in 247 aa overlap); etc. BELONGS TO THE CCMF/CYCK/CCL1/NRFE/CCSA FAMILY. Note that previously known as ccsB.; ccsB; cytochrome C-type biogenesis protein CcsA	619891..620865	Mycobacterium tuberculosis H37Rv	887380
NP_215044.1	CDS	Rv0530	NC_000962.2	620907	622124	D	Rv0530, (MTCY25D10.09), len: 405 aa. Conserved hypothetical protein, similar in part to other hypothetical proteins e.g. AL031231|SC3C3_3|CAA20252.1 from Streptomyces coelicolor (1083 aa), FASTA scores: opt: 870, E(): 0, (39.5% identity in 443 aa overlap); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3868, Rv0282, Rv1798, etc.; hypothetical protein	620907..622124	Mycobacterium tuberculosis H37Rv	887385
NP_215045.1	CDS	Rv0531	NC_000962.2	622329	622646	D	Rv0531, (MTCY25D10.10), len: 105 aa. Possible conserved membrane protein, highly similar to Y13803|MLB1306_1|CAA74131.1 hypothetical protein from Mycobacterium leprae (86 aa), FASTA scores: E(): 2.1e-24, (74.4% identity in 86 aa overlap); and NP_302557.1|NC_002677 putative membrane protein from Mycobacterium leprae (111 aa).; hypothetical protein	622329..622646	Mycobacterium tuberculosis H37Rv	887376
YP_177736.1	CDS	PE_PGRS6	NC_000962.2	622793	624577	D	Rv0532, (MTCY25D10.11), len: 594 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0, (58.2% identity in 536 aa overlap).; PE-PGRS family protein	622793..624577	Mycobacterium tuberculosis H37Rv	887391
NP_215047.1	CDS	fabH	NC_000962.2	624473	625480	R	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III	complement(624473..625480)	Mycobacterium tuberculosis H37Rv	887381
NP_215048.1	CDS	menA	NC_000962.2	625562	626440	R	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase	complement(625562..626440)	Mycobacterium tuberculosis H37Rv	887408
NP_215049.1	CDS	pnp	NC_000962.2	626457	627251	D	Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate; 5'-methylthioadenosine phosphorylase	626457..627251	Mycobacterium tuberculosis H37Rv	887430
YP_177737.1	CDS	galE3	NC_000962.2	627248	628288	D	Rv0536, (MTCY25D10.15), len: 346 aa. Possible galE3, UDP-glucose 4-epimerase (EC 5.1.3.2), highly similar to CAB76986.1|AL159178 putative epimerase from Streptomyces coelicolor (334 aa); and similar to other epimerases e.g. NP_436775.1|NC_003078 putative NDP-glucose dehydrataseepimerase protein from Sinorhizobium meliloti (368 aa); AF143772|AF143772_7 GepiA from Mycobacterium avium strain 2151 (353 aa), FASTA scores: opt: 577, E(): 3.9e-29, (36.6% identity in 352 aa overlap); GALE_METJA|Q57664 putative UDP-glucose 4-epimerase (305 aa), FASTA scores: opt: 300, E(): 1.6e-12, (30.9% identity in 343 aa overlap); etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3634c, Rv3784, etc. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY. Note that previously known as galE2.; galE2; UDP-glucose 4-epimerase	627248..628288	Mycobacterium tuberculosis H37Rv	887457
NP_215051.1	CDS	Rv0537c	NC_000962.2	628298	629731	R	Rv0537c, (MTCY25D10.16c), len: 477 aa. Probable integral membrane protein, showing weak similarity to YDNK_STRCO|P40180 hypothetical 41.2 kDa protein from Streptomyces coelicolor (411 aa), FASTA scores: opt: 122, E(): 0.85, (28.2% identity in 373 aa overlap).; integral membrane protein	complement(628298..629731)	Mycobacterium tuberculosis H37Rv	887465
NP_215052.1	CDS	Rv0538	NC_000962.2	630040	631686	D	Rv0538, (MTCY25D10.17), len: 548 aa. Possible conserved membrane protein. Middle region highly similar to AAB63811.1|AF009829|MBE4863a|O32850 unknown protein from Mycobacterium bovis (295 aa) possible transmembrane protein with a repetitive proline, threonine-rich region at C-terminus.; hypothetical protein	630040..631686	Mycobacterium tuberculosis H37Rv	887473
NP_215053.1	CDS	Rv0539	NC_000962.2	631743	632375	D	Rv0539, (MTCY25D10.18), len: 210 aa. Probable dolichol-P-sugar synthase (EC 2.4.1.-), highly similar to CAB76989.1|AL159178 putative glycosyltransferase from Streptomyces coelicolor (242 aa), and similar to various dolichol-P-sugar synthetases and sugar transferases e.g. NP_126257.1|NC_000868 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE RELATED PROTEIN from Pyrococcus abyssi (211 aa); N-terminus of NP_127133.1|NC_000868 DOLICHOL-P-GLUCOSE SYNTHETASE from Pyrococcus abyssi (378 aa); N-terminus of NP_068880.1|NC_000917 putative dolichol-P-glucose synthetase from Archaeoglobus fulgidus (369 aa), FASTA scores: E(): 2.4e-13, (32. 1% identity in 193 aa overlap); Q26732 DOLICHYL-PHOSPHATE-MANNOSE SYNTHASE PRECURSOR from TRYPANOSOMA BRUCEI (267 aa), FASTA scores: opt: 179, E(): 0.0011, (30.7% identity in 205 aa overlap); etc. Also similar to Rv2051c|MTY25D10_18 from Mycobacterium tuberculosis. Contains S00017 ATP/GTP-binding site motif A (P-loop).; dolichyl-phosphate sugar synthase	631743..632375	Mycobacterium tuberculosis H37Rv	887476
NP_215054.1	CDS	Rv0540	NC_000962.2	632372	633034	D	Rv0540, (MTCY25D10.19), len: 220 aa. Conserved hypothetical protein, similar to hypothetical proteins from Streptomyces coelicolor: CAB76990.1|AL159178 (213 aa); N-terminus of BAA84086.1|AB032065 (446 aa); and CAB61872.1|AL133252|SCE46_21 (210 aa), FASTA scores: opt: 267, E(): 5.3e-10, (32.7% identity in 202 aa overlap). Also some similarity with D90913_63|PCC6803 from Synecho cystis sp (211 aa), FASTA scores: opt: 189, E(): 4.7e-06, (25.3 identity in 194 aa overlap).; hypothetical protein	632372..633034	Mycobacterium tuberculosis H37Rv	887489
NP_215055.1	CDS	Rv0541c	NC_000962.2	633055	634404	R	Rv0541c, (MTCY25D10.20c), len: 449 aa. Probable conserved integral membrane protein, highly similar (except first 40 residues) to CAB76994.1|AL159178 putative integral membrane protein from Streptomyces coelicolor (456 aa). Also some similarity to Q13724|GCS1_HUMAN MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (834 aa), FASTA scores: opt: 150, E(): 0.013, (27.1% identity in 339 aa overlap). Contains PS00041 Bacterial regulatory proteins, araC family signature.; integral membrane protein	complement(633055..634404)	Mycobacterium tuberculosis H37Rv	887416
NP_215056.1	CDS	menE	NC_000962.2	634416	635504	R	Rv0542c, (MTCY25D10.21c), len: 362 aa. Possible menE, O-succinylbenzoic acid-CoA ligase (EC 6.2.1.26), highly similar to Q50170|AAA63145.1|U15187|XCLB 4-Coumarate--CoA ligase from Mycobacterium leprae (352 aa), FASTA scores: opt: 1815, E(): 0, (78.9% identity in 351 aa overlap). Also similar to N-terminus of acid-CoA ligases e.g. NP_471116.1|NC_003212 O-succinylbenzoic acid-CoA ligase from Listeria innocua (469 aa); NP_390957.1|NC_000964 O-succinylbenzoic acid-CoA ligase from Bacillus subtilis (486 aa); MENE_HAEIN|P44565 O-succinylbenzoic acid-CoA ligase from Haemophilus influenzae (452 aa), FASTA scores: opt: 307, E(): 4.6e-12, (25.4% identity in 339 aa overlap); etc. Also some similarity with fadD proteins from Mycobacterium tuberculosis. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.; O-succinylbenzoic acid--CoA ligase	complement(634416..635504)	Mycobacterium tuberculosis H37Rv	887507
NP_215057.1	CDS	Rv0543c	NC_000962.2	635573	635875	R	Rv0543c, (MTCY25D10.22c), len: 100 aa. Conserved hypothetical protein, equivalent to Q50171|MLU15187_32|NP_302469.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (100 aa), FASTA scores: opt: 493, E(): 6.1e-30, (73.5% identity in 98 aa overlap). Some similarity to Rv3046c|NP_217562.1 from Mycobacterium tuberculosis.; hypothetical protein	complement(635573..635875)	Mycobacterium tuberculosis H37Rv	887494
NP_215058.1	CDS	Rv0544c	NC_000962.2	635935	636213	R	Rv0544c, (MTCY25D10.23c), len: 92 aa. Possible conserved transmembrane protein, equivalent to NP_302470.1|NC_002677 possible membrane protein from Mycobacterium leprae (96 aa); and shows some similarity to MLU15187_33|Q50172|U296V from Mycobacterium leprae (36 aa), FASTA scores: opt: 151, E(): 2.1e-05, (71.4% identity in 35 aa overlap). Also some similarity with VATL_NEPNO|Q26250 vacuolar ATP synthase 16 kDa proteolipid from Nephrops norvegicus (159 aa), FASTA scores: opt: 80, E(): 11, (26.1% identity in 88 aa overlap).; transmembrane protein	complement(635935..636213)	Mycobacterium tuberculosis H37Rv	887511
NP_215059.1	CDS	pitA	NC_000962.2	636210	637463	R	Rv0545c, (MTCY25D10.24c), len: 417 aa. Probable pitA, low-affinity inorganic phosphate transporter, integral membrane protein, equivalent to Q50173|NP_302471.1 pitA from Mycobacterium leprae (414 aa), FASTA scores: opt: 2035, E(): 0, (76.3% identity in 418 aa overlap). Also highly similar to others e.g. CAB59461.1|AL132644 putative low-affinity phosphate transport protein from Streptomyces coelicolor (423 aa); PITA_ECOLI|P37308 low-affinity inorganic phosphate transporter from Escherichia coli (499 aa), FASTA scores: opt: 304, E(): 6.9e-10, (32.5 % identity in 234 aa overlap); etc. BELONGS TO THE PHO-4 FAMILY OF TRANSPORTERS, PIT SUBFAMILY.; inorganic phosphate transporter	complement(636210..637463)	Mycobacterium tuberculosis H37Rv	887517
NP_215060.1	CDS	Rv0546c	NC_000962.2	637583	637969	R	Rv0546c, (MTCY25D10.25c), len: 128 aa. Conserved hypothetical protein, equivalent to AAA63111.1|U15187|Q50174|U296X hypothetical protein from Mycobacterium leprae (144 aa), FASTA scores: opt: 748, E(): 0, (84.2% identity in 133 aa overlap). Also highly similar to CAB95979.1|AL360034 conserved hypothetical protein from Streptomyces coelicolor (130 aa); and similar to AE000854_8|O26852 S-D-LACTOYLGLUTATHIONE METHYLGLYOXAL LYASE from Methanobacterium thermoautotropto (116 aa), FASTA scores: opt: 155, E(): 0.00019, (30.6% identity in 108 aa overlap); YAER_ECOLI hypothetical 14.7 kDa protein from Escherichia coli (129 aa), FASTA scores: opt: 104, E(): 0.42, (28.7% identity in 115 aa overlap). Also similar to Rv2068c from Mycobacterium tuberculosis.; hypothetical protein	complement(637583..637969)	Mycobacterium tuberculosis H37Rv	887509
NP_215061.1	CDS	Rv0547c	NC_000962.2	638032	638916	R	Rv0547c, (MTCY25D10.26c), len: 294 aa. Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases e.g. fatty acyl-CoA reductase from Acinetobacter calcoaceticus (295 aa); NP_280196.1|NC_002607 3-oxoacyl-[acyl-carrier-protein] reductase from Halobacterium sp. NRC-1 (255 aa); NP_349214.1|NC_003030 Short-chain alcohol dehydrogenase family protein from Clostridium acetobutylicum (255 aa); etc. Also similar to several proteins from Mycobacterium tuberculosis e.g. Y04M_MYCTU|Q10783 putative oxidoreductase (341 aa), FASTA scores: opt: 644, E(): 0, (46.1% identity in 258 aa overlap).; short chain dehydrogenase	complement(638032..638916)	Mycobacterium tuberculosis H37Rv	887527
NP_215062.1	CDS	menB	NC_000962.2	639012	639956	R	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase	complement(639012..639956)	Mycobacterium tuberculosis H37Rv	887529
NP_215063.1	CDS	Rv0549c	NC_000962.2	640228	640641	R	Rv0549c, (MTCY25D10.28c), len: 137 aa. Conserved hypothetical protein, similar to Rv0960, Rv0065, and Rv1720c from Mycobacterium tuberculosis.; hypothetical protein	complement(640228..640641)	Mycobacterium tuberculosis H37Rv	887534
NP_215064.1	CDS	Rv0550c	NC_000962.2	640638	640904	R	Rv0550c, (MTCY25D10.29c), len: 88 aa. Hypothetical unknown protein.; hypothetical protein	complement(640638..640904)	Mycobacterium tuberculosis H37Rv	887515
NP_215065.1	CDS	fadD8	NC_000962.2	641096	642811	R	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	complement(641096..642811)	Mycobacterium tuberculosis H37Rv	887526
NP_215066.1	CDS	Rv0552	NC_000962.2	642889	644493	D	Rv0552, (MTCY25D10.31), len: 534 aa. Conserved hypothetical protein, similar to others from several organisms. Also shows some similarity with regulatory proteins e.g. AEPA_ERWCA|Q06555 exoenzymes regulatory protein aepA [Precursor] from Erwinia carotovora (465 aa), FASTA scores: opt: 278, E(): 7.6e-11, (23.0% identity in 408 aa overlap). Also similar to Z99119|BSUB0016_28 from Bacillus subtilis (529 aa), FASTA scores: opt: 436, E(): 8.3e-20, (23.8% identity in 547 aa overlap). C-terminus is similar to MLRRNOPR_1 HYPOTHETICAL 17.7 kDa PROTEIN from Mycobacterium leprae (154 aa), FASTA score: (43.1% identity in 160 aa overlap).; hypothetical protein	642889..644493	Mycobacterium tuberculosis H37Rv	887537
NP_215067.1	CDS	menC	NC_000962.2	644490	645470	D	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase	644490..645470	Mycobacterium tuberculosis H37Rv	887544
NP_215068.1	CDS	bpoC	NC_000962.2	645467	646255	D	Rv0554, (MTCY25D10.33), len: 262 aa. Possible bpoC, peroxidase (non-haem peroxidase) (EC 1.11.1.-), equivalent to NP_302477.1|NC_002677 putative hydrolase from Mycobacterium leprae (265 aa). Also highly similar or similar to various hydrolases and peroxidases e.g. CAB38877.1|AL035707|T36181 probable hydrolase from Streptomyces coelicolor (272 aa); CAC48368.1|Y16952 putative hydrolase from Amycolatopsis mediterranei (284 aa); P29715|BPA2_STRAU non-haem bromoperoxidase bpo-a2 (bromide peroxidase) (EC 1.11.1.-) from Streptomyces aureofaciens (277 aa), FASTA scores: opt: 325, E(): 2.3e-15, (29.5% identity in 268 aa overlap); O31168|PRXC_STRAU|CPO|CPOT non-heme chloroperoxidase (chloride peroxidase) (EC 1.11.1.10) from Streptomyces aureofaciens (278 aa); etc. Also similar to M. tuberculosis non-heme haloperoxidases and epoxide hydrolases e.g. Rv1938, Rv3617, etc.; peroxidase BpoC	645467..646255	Mycobacterium tuberculosis H37Rv	887535
NP_215069.1	CDS	menD	NC_000962.2	646298	647962	D	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase	646298..647962	Mycobacterium tuberculosis H37Rv	887554
NP_215070.1	CDS	Rv0556	NC_000962.2	647959	648474	D	Rv0556, (MTCY25D10.35), len: 171 aa. Probable conserved transmembrane protein, equivalent to NP_302479.1|NC_002677 putative membrane protein from Mycobacterium leprae (175 aa).; transmembrane protein	647959..648474	Mycobacterium tuberculosis H37Rv	887551
NP_215071.1	CDS	pimB	NC_000962.2	648536	649672	D	Rv0557, (MTCY25D10.36), len: 378 aa. pimB (alternate gene name: mtfB), mannosyltransferase (EC 2.4.1.-) (see citation below), similar to other various transferases e.g. NP_243554.1|NC_002570 alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans (381 aa); NP_249533.1|NC_002516 probable glycosyl transferase from Pseudomonas aeruginosa (406 aa); NP_419573.1|NC_002696 glycosyl transferase, group 1 family protein, from Caulobacter crescentus (455 aa); etc. Also similar to Q55598 hypothetical 44.9 kDa protein from SYNECHOCYSTIS SP (409 aa), FASTA scores: opt: 703, E(): 0, (33.9% identity in 378 aa overlap); GPI3_YEAST|P32363 n-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (452 aa), FASTA scores: opt: 230, E(): 1.1e-07, (23.5% identity in 328 aa overlap).; mtfB; mannosyltransferase PIMB	648536..649672	Mycobacterium tuberculosis H37Rv	887609
YP_177738.1	CDS	ubiE	NC_000962.2	649689	650393	D	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase	649689..650393	Mycobacterium tuberculosis H37Rv	887591
NP_215073.1	CDS	Rv0559c	NC_000962.2	650407	650745	R	Rv0559c, (MTCY25D10.38c), len: 112 aa. Possible conserved secreted protein, similar to NP_302481.1|NC_002677 putative secreted protein from Mycobacterium leprae (112 aa). Also similar to Y08B_MYCTU|Q11048 hypothetical 11.6 kDa protein FASTA scores: opt: 111, E(): 011, (25.4% identity in 114 aa overlap). Contains possible N-terminal signal sequence.; hypothetical protein	complement(650407..650745)	Mycobacterium tuberculosis H37Rv	887569
NP_215074.1	CDS	Rv0560c	NC_000962.2	650779	651504	R	Rv0560c, (MTCY25D10.39c), len: 271 aa. Possible benzoquinone methyltransferase (EC 2.1.1.-) (see citation below), similar to other hypothetical proteins and methyltransferases e.g. Q54300 METHYLTRANSFERASE (211 aa), FASTA scores: opt: 203, E(): 4.8e-07, (30.9% identity in 136 aa overlap). Similar to Rv3699, Rv1377c, Rv2675c, etc from Mycobacterium tuberculosis. Rv0560c can be induced by salicylate and para-amino-salicylate (PAS).; benzoquinone methyltransferase	complement(650779..651504)	Mycobacterium tuberculosis H37Rv	887637
NP_215075.1	CDS	Rv0561c	NC_000962.2	651529	652755	R	Rv0561c, (MTCY25D10.40c), len: 408 aa. Possible oxidoreductase (EC 1.-.-.-), highly similar (except in first 30 aa) to NP_302482.1|NC_002677 putative FAD-linked oxidoreductase from Mycobacterium leprae (408 aa). Also similar to T34627 probable electron transfer oxidoreductase from Streptomyces coelicolor (430 aa); and some bacteriochlorophyll synthases e.g. NP_069300.1|NC_000917 bacteriochlorophyll synthase from Archaeoglobus fulgidus (410 aa); Q55087 GERANYLGERANYL HYDROGENASE (407 aa), FASTA scores: opt: 208, E(): 1.7e-06, (26.9% identity in 327 aa overlap).; oxidoreductase	complement(651529..652755)	Mycobacterium tuberculosis H37Rv	887638
NP_215076.1	CDS	grcC1	NC_000962.2	652771	653778	D	Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1, polyprenyl diphosphate synthetase (EC 2.5.1.-), equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta (EC 2.5.1.30) or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31, (33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE (325 aa); Rv3383c, Rv3398c, etc. Contains PS00444 Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY.; polyprenyl-diphosphate synthase	652771..653778	Mycobacterium tuberculosis H37Rv	887647
NP_215077.1	CDS	htpX	NC_000962.2	653879	654739	D	putative metalloprotease; heat shock protein HtpX	653879..654739	Mycobacterium tuberculosis H37Rv	887649
NP_215078.1	CDS	gpsA	NC_000962.2	654924	655949	R	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	complement(654924..655949)	Mycobacterium tuberculosis H37Rv	887651
NP_215079.1	CDS	Rv0565c	NC_000962.2	656010	657470	R	Rv0565c, (MTV039.03c), len: 486 aa. Probable monoxygenase (EC 1.14.-.-), highly similar to NP_301173.1|NC_002677 putative monooxygenase from Mycobacterium leprae (494 aa). Also highly similar to others e.g. NP_421371.1|NC_002696 monooxygenase (flavin-binding family) from Caulobacter crescentus (498 aa); C-terminus of NP_051574.1|NC_000958 arylesterase/monoxygenase from Deinococcus radiodurans (833 aa); P12015|CYMO_ACISP CYCLOHEXANONE MONOOXYGENASE (EC 1.14.13.22) from Acinetobacter sp. (542 aa), FASTA scores: opt: 354, E(): 2.1e-16, (23.7% identity in 435 aa overlap); etc. Also similar to other putative monoxygenases from Mycobacterium tuberculosis e.g. Rv3854c (489 aa), MTCY01A6.14 (489 aa), MTV013_4 (495 aa), MTCY31.20 (495 aa). TBparse score is 0.902.; monooxygenase	complement(656010..657470)	Mycobacterium tuberculosis H37Rv	887662
NP_215080.1	CDS	Rv0566c	NC_000962.2	657548	658039	R	putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein	complement(657548..658039)	Mycobacterium tuberculosis H37Rv	887633
NP_215081.1	CDS	Rv0567	NC_000962.2	658321	659340	D	Rv0567, (MTV039.05), len: 339 aa. Probable methyltransferase (EC 2.1.1.-), similar to several e.g. P39896|TCMO_STRGA TETRACENOMYCIN POLYKETIDE SYNTHESIS 8-O-METHYLTRANSFERASE from Streptomyces glaucescens (339 aa), FASTA scores: opt: 685, E(): 0, (35.8% identity in 335 aa overlap); P10950|HIOM_BOVIN HYDROXYINDOLE O-METHYLTRANSFERASE (EC 2.1.1.4) from Bos taurus (345 aa), FASTA scores: opt: 509, E(): 3.4e-27, (30.7% identity in 332 aa overlap) etc. TBparse score is 0.910.; methyltransferase/methylase	658321..659340	Mycobacterium tuberculosis H37Rv	887667
NP_215082.1	CDS	cyp135B1	NC_000962.2	659450	660868	D	Rv0568, (MT0594, MTV039.06), len: 472 aa. Possible cyp135B1, cytochrome P450 (EC 1.14.-.-), similar to putative cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. P29980|CPXN_ANASP PROBABLE CYTOCHROME P450 from Anabaena sp. strain PCC 7120 (459 aa), FASTA scores: opt: 525, E(): 7.2e-27, (31.9% identity in 417 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0327c|NP_214841.1|NC_000962|CYP135A1|MT0342|MTCY63.32c PUTATIVE CYTOCHROME P450 (449 aa), FASTA scores: opt: 1080, E(): 0, (40.5% identity in 444 aa overlap); Rv3685c|NP_218202.1|NC_000962 PUTATIVE CYTOCHROME P450 (476 aa); Rv0136|NP_214650.1|NC_000962 PUTATIVE CYTOCHROME P450 (441 aa); etc. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). TBparse score is 0.896.; cytochrome P450 135B1	659450..660868	Mycobacterium tuberculosis H37Rv	887654
NP_215083.1	CDS	Rv0569	NC_000962.2	661003	661269	D	Rv0569, (MTV039.07), len: 88 aa. Conserved hypothetical protein. C-terminus highly similar to AAA63065.1|U15184|MLU15184_10 hypothetical protein from Mycobacterium leprae (53 aa), FASTA scores: opt: 140, E(): 0.0046, (64.7% identity in 34 aa overlap). Also similar to T36824|SCI35.11 hypothetical protein from Streptomyces coelicolor (64 aa); and N-terminus of T36956 probable DNA-binding protein from Streptomyces coelicolor (323 aa). Also highly similar to Rv2302|MTCY339.07c|NP_216818.1|NC_000962 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (80 aa), FASTA scores: opt: 300, E(): 1.4e-13, (61.8% identity in 76 aa overlap). TBparse score is 0.932.; hypothetical protein	661003..661269	Mycobacterium tuberculosis H37Rv	887678
NP_215084.1	CDS	nrdZ	NC_000962.2	661295	663373	D	Rv0570, (MTV039.08), len: 692 aa. Probable nrdZ, ribonucleoside-diphosphate reductase, large subunit (EC 1.17.4.-), highly similar to others e.g. NP_070492.1|NC_000917|NRD|AE000988_11 ribonucleotide reductase from Archaeoglobus fulgidus (752 aa), FASTA scores: opt: 2001, E(): 0, (52.5% identity in 562 aa overlap) (N-terminus shorter); U73619|TAU73619_1|T37459 ribonucleotide reductase from Thermoplasma acidophilum (857 aa), FASTA scores: opt: 1678, E(): 0, (43.7% identity in 723 aa overlap); etc. BELONGS TO THE RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE LARGE CHAIN FAMILY. TBparse score is 0.907.; ribonucleoside-diphosphate reductase large subunit NrdZ	661295..663373	Mycobacterium tuberculosis H37Rv	887666
NP_215085.1	CDS	Rv0571c	NC_000962.2	663487	664818	R	Rv0571c, (MTV039.09c), len: 443 aa. Conserved hypothetical protein, highly similar to the products of two adjacent orfs in Mycobacterium leprae: AAA63059.1|U15184|U650S|Q50111 hypothetical protein (258 aa), FASTA scores: opt: 1071, E(): 0, (72.5% identity in 233 aa overlap); and AAA63058.1|U15184|U650T hypothetical protein (86 aa), FASTA scores: opt: 192, E(): 6.4e-06, (70.8% identity in 48 aa overlap). Also similar to others e.g. NP_107072.1|NC_002678 hypothetical protein from Mesorhizobium loti (235 aa); NP_213031.1|NC_000918 hypothetical protein from Aquifex aeolicus (175 aa); etc. And similar to part of hypothetical proteins from Mycobacterium tuberculosis e.g. C-terminus of Rv2143|MTCY270.25c|Z95388|NP_216659.1|NC_000962 (352 aa), FASTA scores: opt: 592, E(): 7e-32, (49.3% identity in 205 aa overlap); N-terminus of Rv2030c|NP_216546.1|NC_000962 (681 aa). TBparse score is 0.908.; hypothetical protein	complement(663487..664818)	Mycobacterium tuberculosis H37Rv	887710
NP_215086.1	CDS	Rv0572c	NC_000962.2	665042	665383	R	Rv0572c, (MTV039.10c), len: 113 aa. Hypothetical unknown protein.; hypothetical protein	complement(665042..665383)	Mycobacterium tuberculosis H37Rv	887696
NP_215087.1	CDS	Rv0573c	NC_000962.2	665851	667242	R	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase	complement(665851..667242)	Mycobacterium tuberculosis H37Rv	887716
NP_215088.1	CDS	Rv0574c	NC_000962.2	667252	668394	R	Rv0574c, (MTV039.12c), len: 380 aa. Conserved hypothetical protein, showing similarity with other hypothetical proteins and polyglutamate synthases (encapsulation proteins) e.g. AAK64444.1|AF377339_5|AF377339 polyglutamate synthase CapA from Myxococcus xanthus (405 aa); M24150|BACCAPABC_3|CapA polyglutamate synthase (encapsulation protein) from B.anthracis (411 aa), FASTA scores: opt: 261, E(): 4.3e-10, (25.8% identity in 287 aa overlap); etc. TBparse score is 0.920.; hypothetical protein	complement(667252..668394)	Mycobacterium tuberculosis H37Rv	887721
NP_215089.1	CDS	Rv0575c	NC_000962.2	668579	669745	R	Rv0575c, (MTV039.13c), len: 388 aa. Possible oxidoreductase (EC 1.-.-.-), similar to many diverse oxidoreductases and monooxygenases e.g. AL109974|SCF34_5|T36404 probable monooxygenase from Streptomyces coelicolor (407 aa), FASTA scores: opt: 786, E(): 0, (38.7% identity in 398 aa overlap); P96555|AB000564 SALICYLATE HYDROXYLASE from SPHINGOMONAS (395 aa), FASTA scores: opt: 267, E():5e-11, (26.4% identity in 390 aa overlap). Also similar to Rv1260|Z77137|MTCY50.22C from Mycobacterium tuberculosis (372 aa), FASTA scores: opt: 762, E(): 0, (40.9% identity in 345 aa overlap). TBparse score is 0.868. The transcription of this CDS seems to be activated in macrophages (see citation below).; hypothetical protein	complement(668579..669745)	Mycobacterium tuberculosis H37Rv	887720
NP_215090.1	CDS	Rv0576	NC_000962.2	669848	671152	D	Rv0576, (MTV039.14), len: 434 aa. Probable transcriptional regulator, ArsR family. N-terminus highly similar to others e.g. NP_102487.1|NC_002678 transcriptional regulator from Mesorhizobium loti (104 aa); NP_242952.1|NC_002570 transcriptional regulator (ArsR family) from Bacillus halodurans (109 aa); etc. C-terminal region ( 240-434) shows similarity with D67028_1 from Rhodococcus rhodochrous (112 aa); and Rv0738 from Mycobacterium tuberculosis (182 aa). N-terminus also highly similar to Rv2034 from Mycobacterium tuberculosis (107 aa). Contains helix-turn-helix motif at aa 23-43 (Score 1628, +4.73 SD). TBparse score is 0.901.; ArsR family transcriptional regulator	669848..671152	Mycobacterium tuberculosis H37Rv	887717
NP_215091.1	CDS	TB27.3	NC_000962.2	671166	671951	D	Rv0577, (MTV039.15), len: 261 aa. TB27.3, conserved hypothetical protein. Corresponds to O53774|CF30_MYCTU 27 kDa ANTIGEN CFP30B from Mycobacterium tuberculosis culture filtrate (260 aa), FASTA scores: opt: 1781, E(): 0, (100.0% identity in 260 aa overlap). Also similar to several hypothetical proteins and hydroxylases from Steptomyces sp. e.g. T35032 probable hydroxylase from Streptomyces coelicolor (263 aa); Q55078 orfA gene product from Streptomyces sp. (275 aa), FASTA scores: E(): 1.5e-1 9, (38.6% identity in 264 aa overlap); D89734_1|P95754 DNA for SgaA SGAA PROTEIN from Streptomyces griseus; and SC9B10_20 from Streptomyces coelicolor (267 aa), FASTA score: (38.9 identity in 252 aa overlap). Also similar to Rv0911|MTCY21C12.05 from Mycobacterium tuberculosis (257 aa), FASTA scores: E(): 1.1e-20, (32.0% identity in 259 aa overlap). TBparse score is 0.899.; hypothetical protein	671166..671951	Mycobacterium tuberculosis H37Rv	887732
YP_177739.1	CDS	PE_PGRS7	NC_000962.2	671996	675916	R	Rv0578c, (MTV039.16c), len: 1306 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to many other PGRS proteins e.g. MTCY493.04|Z95844 from Mycobacterium tuberculosis (1329 aa), FASTA scores: opt: 3994, E(): 0, (54.6% identity in 1375 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures possibly fortuitously. TBparse score is 0.867.; PE-PGRS family protein	complement(671996..675916)	Mycobacterium tuberculosis H37Rv	887725
NP_215093.1	CDS	Rv0579	NC_000962.2	676238	676996	D	Rv0579, (MTV039.17), len: 252 aa. Conserved hypothetical protein, showing some similarity to others e.g. AE001747_4 hypothetical protein from Thermotoga maritima (247 aa), FASTA scores: opt: 612, E(): 0, (39.6% identity in 235 aa overlap); AE001004_2 hypothetical protein from Archaeoglobus fulgidus (159 aa), FASTA scores: opt: 196, E(): 1e-06, (28.3% identity in 159 aa overlap); etc. TBparse score is 0.911.; hypothetical protein	676238..676996	Mycobacterium tuberculosis H37Rv	887738
NP_215094.1	CDS	Rv0580c	NC_000962.2	677125	677616	R	Rv0580c, (MTV039.18c), len: 163 aa. Conserved hypothetical protein, equivalent to AAA90989.1|U20446|MK35 lipoprotein precursor from Mycobacterium kansasii (225 aa). TBparse score is 0.910.; hypothetical protein	complement(677125..677616)	Mycobacterium tuberculosis H37Rv	887712
NP_215095.1	CDS	Rv0581	NC_000962.2	677710	677925	D	Rv0581, (MTV039.19), len: 71 aa. Conserved hypothetical protein, showing weak similarity to several Mycobacterium tuberculosis proteins including P95003|Z83863|Rv2550c|MTCY159_6 CONSERVED HYPOTHETICAL PROTEIN (81 aa), FASTA scores: opt: 93, E(): 3.2, (25.7% identity in 70 aa overlap); Rv2871; Rv1241; etc. Also shows weak similarity to X05648|SGSPH_1 from Streptomyces glaucescens (77 aa), FASTA scores: opt: 92, E(): 3.6, (35.4% identity in 65 aa overlap). TBparse score is 0.864.; hypothetical protein	677710..677925	Mycobacterium tuberculosis H37Rv	887739
NP_215096.1	CDS	Rv0582	NC_000962.2	677922	678329	D	Rv0582, (MTV039.20), len: 135 aa. Hypothetical unknown protein. TBparse score is 0.894.; hypothetical protein	677922..678329	Mycobacterium tuberculosis H37Rv	887747
NP_215097.1	CDS	lpqN	NC_000962.2	678389	679075	R	Rv0583c, (MTV039.21c), len: 228 aa. Probable lpqN, conserved lipoprotein, equivalent to AAA90989.1|U20446|MK35|U20446|MKU20446_1 lipoprotein precursor from Mycobacterium kansasii (225 aa), FASTA scores: opt: 945, E(): 0, (62.7% identity in 228 aa overlap); and similar to others from Mycobacteria e.g. Rv0040c and Rv1016c from Mycobacterium tuberculosis. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.908.; lipoprotein LpqN	complement(678389..679075)	Mycobacterium tuberculosis H37Rv	887733
NP_215098.1	CDS	Rv0584	NC_000962.2	679229	681862	D	Rv0584, (MTV039.22), len: 877 aa. Possible conserved exported protein, similar to other hypothetical proteins which are not necessarily secreted e.g. CAB61925.1|AL133278 putative secreted protein from Streptomyces coelicolor (772 aa); AAD51075.1|AF175722_1|AF175722 immunoreactive 89kD antigen PG87 from Porphyromonas gingivalis (781 aa), FASTA scores: opt: 637, E(): 2.1e-30, (29.1% identity in 794 aa overlap); etc. Contains PS00699 Nitrogenases component 1 alpha and beta subunits signature 1. Has potential N-terminal signal peptide. TBparse score is 0.913.; hypothetical protein	679229..681862	Mycobacterium tuberculosis H37Rv	887752
NP_215099.1	CDS	Rv0585c	NC_000962.2	681885	684272	R	Rv0585c, (MTV039.23c, MTCY19H5.37), len: 795 aa. Probable conserved integral membrane protein. C-terminus similar to CAB88984.1|AL353864 putative integral membrane protein from Streptomyces coelicolor (299 aa); and C-terminal region of CAC01311.1|AL390968 putative integral membrane protein from Streptomyces coelicolor (925 aa). Also some similarity with Rv0204 from Mycobacterium tuberculosis. TBparse score is 0.928.; integral membrane protein	complement(681885..684272)	Mycobacterium tuberculosis H37Rv	887753
NP_215100.1	CDS	Rv0586	NC_000962.2	684410	685132	D	Rv0586, (MTCY19H5.36c), len: 240 aa. Probable transcriptional regulator, GntR family, similar to many e.g. P33233|LLDR_ECOLI putative L-lactate dehydrogenase operon regulatory protein from Escherichia coli (258 aa), FASTA scores: opt: 225, E(): 9.3e-08, (26.7% identity in 232 aa overlap); etc. Also similar to other M. tuberculosis transcriptional regulators GntR proteins e.g. Rv3060c, Rv0792c, etc. Contains PS00043 Bacterial regulatory proteins, gntR family signature and probable helix-turn helix motif from aa 35-56 (Score 1531, +4.40 SD).; GntR family transcriptional regulator	684410..685132	Mycobacterium tuberculosis H37Rv	887754
NP_215101.1	CDS	yrbE2A	NC_000962.2	685129	685926	D	Rv0587, (MTCY19H5.35c), len: 265 aa. yrbE2A, hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEA type, e.g. P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichia coli (260 aa), FASTA scores: opt: 287, E(): 6.1e-12, (21.5% identity in 256 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 311, E(): 1.8e-83, (24.2% identity in 265 aa overlap); NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa); etc.; integral membrane protein YrbE2a	685129..685926	Mycobacterium tuberculosis H37Rv	887755
NP_215102.1	CDS	yrbE2B	NC_000962.2	685928	686815	D	Rv0588, (MTCY19H5.34c), len: 295 aa. yrbE2B, hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichia coli (260 aa), FASTA scores: opt: 232, E(): 8.4e-08, (22.1 % identity in 267 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical protei from Haemophilus influenzae (261 aa), FASTA scores: opt: 234, E(): 6.3e-08, (24.2% identity in 215 aa overlap); NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa); etc.; integral membrane protein YrbE2b	685928..686815	Mycobacterium tuberculosis H37Rv	887761
YP_177740.1	CDS	mce2A	NC_000962.2	686821	688035	D	Rv0589, (MTCY19H5.33c), len: 404 aa. mce2A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa); NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa); CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa); etc. Also highly similar, but longer 21 aa, to P72013|CAA50257.1|X70901|MTCI28.08 Mcep protein from Mycobacterium tuberculosis (432 aa), FASTA scores: opt: 1324, E(): 0, (62.6% identity in 436 aa overlap). Contains a possible N-terminal signal or anchor sequence. Note that previously known as mce2.; mce2; MCE-family protein MCE2A	686821..688035	Mycobacterium tuberculosis H37Rv	887745
NP_215104.1	CDS	mce2B	NC_000962.2	688032	688859	D	Rv0590, (MTCY19H5.32c), len: 275 aa. mce2B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); P45391|YRBD_ECOLI hypothetical 19.6 kDa protein from Escherichia coli (183 aa), FASTA scores: opt: 160, E(): 0.00099, (28.3% identity in 166 aa overlap); P45029|YRBD_HAEIN|HI1085 hypothetical protein from Haemophilus influenzae (167 aa), FASTA scores: opt: 135, E():0.035, (25.9% identity in 143 aa overlap); etc. Contains possible N-terminal signal or anchor sequence.; MCE-family protein MCE2B	688032..688859	Mycobacterium tuberculosis H37Rv	887771
YP_177627.1	CDS	Rv0590A	NC_000962.2	688808	689062	D	Rv0590A, len: 84 aa. Probable continuation of mce2B|Rv0590. Can find no frameshift to account for this. Possible nucleotide G missing at 688793 as there are 5 in Mycobacterium bovis but only 4 in CDC1551. Strong similarity to C-terminus of other Mce proteins e.g. AL583926|AL583926_38 from Mycobacterium leprae strain TN (346 aa), FASTA scores: E(): 1.2e-20, (67.85% identity in 84 aa overlap).; MCE family-like protein	688808..689062	Mycobacterium tuberculosis H37Rv	3205078
NP_215105.1	CDS	mce2C	NC_000962.2	689059	690504	D	Rv0591, (MTCY19H5.31c), len: 481 aa. mce2C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and may contain N-terminal signal or anchor sequence. Has highly Pro-rich C-terminus.; MCE-family protein MCE2C	689059..690504	Mycobacterium tuberculosis H37Rv	887770
NP_215106.1	CDS	mce2D	NC_000962.2	690501	692027	D	Rv0592, (MTCY19H5.30c), len: 508 aa. mce2D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich C-terminus and may contain N-terminal signal or anchor sequence.; MCE-family protein MCE2D	690501..692027	Mycobacterium tuberculosis H37Rv	887786
NP_215107.1	CDS	lprL	NC_000962.2	692024	693232	D	Rv0593, (MTCY19H5.29c), len: 402 aa. Possible lprL (alternate gene name: mce2E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa); etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa); CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa); etc. Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; mce2E; MCE-family lipoprotein LprL	692024..693232	Mycobacterium tuberculosis H37Rv	887829
NP_215108.1	CDS	mce2F	NC_000962.2	693237	694787	D	Rv0594, (MTCY19H5.28c), len: 516 aa. mce2F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from Mycobacterium avium (80 aa) (similarity on C-terminus); CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa); etc. Contains possible N-terminal signal or anchor sequence.; MCE-family protein MCE2F	693237..694787	Mycobacterium tuberculosis H37Rv	887797
NP_215109.1	CDS	Rv0595c	NC_000962.2	694839	695231	R	Rv0595c, (MTCY19H5.27), len: 130 aa. Conserved hypothetical protein, similar to other conserved hypothetical proteins e.g. Rv0627 (135 aa) and Rv0665 (112 aa) from Mycobacterium tuberculosis; and STBB_PSESM|Q52562 plasmid stability protein from Pseudomonas syringae (139 aa), FASTA scores: opt: 131, E(): 0.0035, (35.2% identity in 88 aa overlap).; hypothetical protein	complement(694839..695231)	Mycobacterium tuberculosis H37Rv	887835
NP_215110.1	CDS	Rv0596c	NC_000962.2	695228	695485	R	Rv0596c, (MTCY19H5.26), len: 85 aa. Conserved hypothetical protein, highly similar in part to other M. tuberculosis hypothetical proteins e.g. Rv0626, Rv3181c, Rv3385c, Rv3407, etc.; hypothetical protein	complement(695228..695485)	Mycobacterium tuberculosis H37Rv	887846
NP_215111.1	CDS	Rv0597c	NC_000962.2	695668	696903	R	Rv0597c, (MTCY19H5.25), len: 411 aa. Conserved hypothetical protein, highly similar to Rv3179 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (429 aa). Also similar to AAF76191.1|AF271296_1|AF271296 putative ATP/GTP binding protein from Mycobacterium smegmatis (428 aa); Rv2008c|YW09_MYCTU|Q10849 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (441 aa), FASTA scores: opt: 270, E(): 3.6e-11, (30.5% identity in 416 aa overlap) (N-terminus longer). Also similar to other hypothetical proteins e.g. NP_085874.1|NC_002679 hypothetical protein from Mesorhizobium loti (435 aa) (N-terminus longer). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	complement(695668..696903)	Mycobacterium tuberculosis H37Rv	887853
NP_215112.1	CDS	Rv0598c	NC_000962.2	697154	697567	R	Rv0598c, (MTCY19H5.24), len: 137 aa. Conserved hypothetical protein; similar to Rv2596|Y0B5_MYCTU|Q50625 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (134 aa), FASTA scores: opt: 254, E(): 8.2e-12, (41.5% identity in 130 aa overlap).; hypothetical protein	complement(697154..697567)	Mycobacterium tuberculosis H37Rv	887861
NP_215113.1	CDS	Rv0599c	NC_000962.2	697564	697800	R	Rv0599c, (MTCY19H5.23), len: 78 aa. Conserved hypothetical protein, similar to Rv2595|Y0B6_MYCTU|Q50626 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (81 aa), FASTA scores: opt: 160, E(): 6.2e-07, (35.8% identity in 81 aa overlap). N-terminus shows stong similarity with N-terminus of NP_104908.1|NC_002678 hypothetical protein from Mesorhizobium loti (89 aa).; hypothetical protein	complement(697564..697800)	Mycobacterium tuberculosis H37Rv	887856
NP_215114.2	CDS	Rv0600c	NC_000962.2	697904	698410	R	Rv0600c, (MTCY19H5.22), len: 168 aa (probable partial CDS). Probable two-component sensor kinase (second part) (EC 2.7.3.-), similar to part (C-termini) of many others e.g. Q04943|AFQ2_STRCO sensor protein afsq2 from Streptomyces coelicolor (535 aa), FASTA scores: opt: 347, E(): 1.9e-12, (33.0% identity in 206 aa overlap); etc. Note that sequence was checked and no errors were detected, which would allow this and the upstream ORF to be joined. Start changed since first submission (- 39 aa).; two component sensor kinase	complement(697904..698410)	Mycobacterium tuberculosis H37Rv	887847
NP_215115.1	CDS	Rv0601c	NC_000962.2	698524	698994	R	Rv0601c, (MTCY19H5.21), len: 156 aa (probable partial CDS). Probable two-component sensor kinase (first part) (EC 2.7.3.-), similar to part (N-termini) of others e.g. Q0375|CUTS_STRLI cuts protein from streptomyces lividans (414 aa), FASTA scores: opt: 230, E(): 3.1e-08, (39.1% identity in 115 aa overlap). Note that the sequence was checked and no errors were detected that would allow this and the downstream ORF to be joined.; two component sensor kinase	complement(698524..698994)	Mycobacterium tuberculosis H37Rv	887868
NP_215116.1	CDS	tcrA	NC_000962.2	699038	699799	R	Rv0602c, (MTCY19H5.20), len: 253 aa. Probable tcrA, two-component DNA-binding response regulator, highly similar to others e.g. NP_107959.1|NC_002678 two-component response regulator from Mesorhizobium loti (239 aa); etc. Also similar to many other Mycobacterium tuberculosis two-component regulators e.g. Q50806|MTCY10G2.16|Rv1033c RESPONSE REGULATOR HOMOLOG TRCR (TCRV) (257 aa), FASTA score: (47.4 identity in 232 aa overlap); etc.; two component DNA binding transcriptional regulatory protein TCRA	complement(699038..699799)	Mycobacterium tuberculosis H37Rv	887870
NP_215117.1	CDS	Rv0603	NC_000962.2	699856	700167	D	Rv0603, (MTCY19H5.19c), len: 103 aa. Possible exported protein with hydrophobic stretch at aa 7-29.; hypothetical protein	699856..700167	Mycobacterium tuberculosis H37Rv	887863
NP_215118.1	CDS	lpqO	NC_000962.2	700239	701189	D	Rv0604, (MTCY19H5.18c), len: 316 aa. Probable lpqO, conserved lipoprotein, highly similar to Rv2999|lppY PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (321 aa), FASTA scores: opt: 1153, E(): 0, (53.2% identity in 312 aa overlap). Contains probable N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein lpqo	700239..701189	Mycobacterium tuberculosis H37Rv	887879
NP_215119.1	CDS	Rv0605	NC_000962.2	701406	702014	D	Rv0605, (MTCY19H5.17c), len: 202 aa. Possible resolvase for IS_Y349 element, similar to several Mycobacterial hypothetical proteins and weakly similar to Q52563 resolvase from Pseudomonas syringae (210 aa), FASTA scores: opt: 99, E(): 3.1, (35.7% identity in 98 aa overlap). Contains PS00397 Site-specific recombinases active site and probable helix-turn helix motif from aa 9-30 (Score 1815, +5.37 SD).; resolvase	701406..702014	Mycobacterium tuberculosis H37Rv	887872
NP_215120.1	CDS	Rv0606	NC_000962.2	702016	702759	D	Rv0606, (MTCY19H5.16c), len: 247 aa. Possible truncated transposase for IS_1536 element, highly similar to N-terminus of other transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809|Rv2885c|MT2953|MTCY274.16c PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis (460 aa), FASTA scores: opt: 1368, E(): 0, (83.5% identity in 237 aa overlap); Rv2978c, Rv0922, Rv3827c, etc. Also similar to N-terminus of MTV002_57|Rv2792 RESOLVASE from M. tuberculosis (193 aa), FASTA score: (87.4% identity in 238 aa overlap).; hypothetical protein	702016..702759	Mycobacterium tuberculosis H37Rv	887889
NP_215121.1	CDS	Rv0607	NC_000962.2	702813	703199	D	Rv0607, (MTCY19H5.15c), len: 128 aa. Hypothetical unknown protein.; hypothetical protein	702813..703199	Mycobacterium tuberculosis H37Rv	887883
NP_215122.1	CDS	Rv0608	NC_000962.2	703244	703489	D	Rv0608, (MTCY19H5.14c), len: 81 aa. Conserved hypothetical protein, similar to several other M. tuberculosis hypothetical short proteins e.g. Rv0623|P96913|MTCY20H10.04 (84 aa), FASTA scores: opt: 159, E(): 1.2e-09, (43.0% identity in 86 aa overlap); Rv2760c (89 aa); Rv1740 (70 aa), etc.; hypothetical protein	703244..703489	Mycobacterium tuberculosis H37Rv	887895
NP_215123.1	CDS	Rv0609	NC_000962.2	703486	703887	D	Rv0609, (MTCY19H5.13c), len: 133 aa. Conserved hypothetical protein, similar to several Mycobacterium tuberculosis hypothetical proteins e.g. YW37_MYCTU|Q10874|Rv1982c|MT2034|MTCY39.37 CONSERVED HYPOTHETICAL PROTEIN (139 aa), FASTA scores: opt: 262, E(): 8.1e-12, (39.1% identity in 128 aa overlap); MTCY20H10.05|Rv0624|MT0652|MTCY20H10.05 CONSERVED HYPOTHETICAL PROTEIN (131 aa), FASTA score: (42.9% identity in 126 aa overlap), Rv0565c, Rv3854c, etc.; hypothetical protein	703486..703887	Mycobacterium tuberculosis H37Rv	887896
YP_177628.1	CDS	Rv0609A	NC_000962.2	703830	704057	D	Rv0609A, len: 75 aa. Conserved hypothetical protein, highly similar to part of upstream ORF Rv0612|MTCY19H5.09c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (201 aa), FASTA scores: opt: 154, E(): 1.8e-05, (74.3% identity in 35 aa overlap).; hypothetical protein	703830..704057	Mycobacterium tuberculosis H37Rv	3205046
NP_215124.1	CDS	Rv0610c	NC_000962.2	704752	705909	R	Rv0610c, (MTCY19H5.11), len: 385 aa. Hypothetical unknown protein.; hypothetical protein	complement(704752..705909)	Mycobacterium tuberculosis H37Rv	887890
NP_215125.1	CDS	Rv0611c	NC_000962.2	705961	706344	R	Rv0611c, (MTCY19H5.10), len: 127 aa. Hypothetical unknown protein. Note that first start has been taken although this overlaps slightly with the upstream ORF.; hypothetical protein	complement(705961..706344)	Mycobacterium tuberculosis H37Rv	887906
NP_215126.1	CDS	Rv0612	NC_000962.2	706324	706929	D	Rv0612, (MTCY19H5.09c), len: 201 aa. Conserved hypothetical protein, highly similar, but in part, to downstream ORF Rv0609A CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (75 aa); and showing weak similarity with other hypothetical proteins from Mycobacterium tuberculosis. Note that first start has been taken although this overlaps slightly with the upstream ORF.; hypothetical protein	706324..706929	Mycobacterium tuberculosis H37Rv	887908
NP_215127.1	CDS	Rv0613c	NC_000962.2	706948	709515	R	Rv0613c, (MTCY19H5.08), len: 855 aa. Hypothetical unknown protein. Contains a very short region with strong similarity to several preprotein translocases e.g. P47847|SECA_LISMO preprotein translocase seca subunit (836 aa), FASTA scores: opt: 138, E(): 0.18, (38.6% identity in 70 aa overlap, and 72.7% identity in 22 aa overlap).; hypothetical protein	complement(706948..709515)	Mycobacterium tuberculosis H37Rv	887913
NP_215128.1	CDS	Rv0614	NC_000962.2	709356	710348	D	Rv0614, (MTCY19H5.07c), len: 330 aa. Conserved hypothetical protein, similar in part to Mycobacterium tuberculosis hypothetical proteins e.g. YY16_MYCTU|Q10685|Rv2077c|MT2137|MTCY49.16c CONSERVED HYPOTHETICAL PROTEIN (323 aa), FASTA scores: opt: 200, E(): 0.00016, (28.3% identity in 269 aa overlap); MTCY9F9_15 FASTA score: (40.3% identity in 144 aa overlap), Rv1949c, Rv2542, etc. Several start sites are possible; first start has been chosen. Note that this ORF overlaps with the upstream ORF.; hypothetical protein	709356..710348	Mycobacterium tuberculosis H37Rv	887914
NP_215129.1	CDS	Rv0615	NC_000962.2	710345	710587	D	Rv0615, (MTCY19H5.06c), len: 80 aa. Probable integral membrane protein.; integral membrane protein	710345..710587	Mycobacterium tuberculosis H37Rv	887920
NP_215130.1	CDS	Rv0616c	NC_000962.2	710584	710850	R	Rv0616c, (MTCY19H5.05), len: 88 aa. Hypothetical unknown protein.; hypothetical protein	complement(710584..710850)	Mycobacterium tuberculosis H37Rv	887921
NP_215131.1	CDS	Rv0617	NC_000962.2	711006	711407	D	Rv0617, (MTCY19H5.04c), len: 133 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv2494, Rv3320c, Rv0749, Rv0277c, Rv2530c, etc.; hypothetical protein	711006..711407	Mycobacterium tuberculosis H37Rv	887926
YP_177741.1	CDS	galTa	NC_000962.2	711536	712231	D	FIRST PART; Rv0618, (MTCY19H5.03c), len: 231 aa (probable partial CDS). Probable galTa, first part of galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), highly similar to N-terminal half of other galT proteins e.g. P13212|GAL7_STRLI galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa), FASTA scores: opt: 296, E(): 1.4e-11, (50.8% identity in 177 aa overlap); etc. Also highly similar to N-terminal half of some UDP glucose--hexose-1-phosphate uridylyltransferases (EC 2.7.7.12). N-terminal 28 aa similar to MTCY20H11.08|Rv0627|MTCY20H11.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 aa), FASTA score: (71.4% identity in 28 overlap). Cosmid sequence is correct but there may be a frameshift mutation in this region which would allow the two ORFs to be joined. BELONGS TO THE GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE FAMILY 1. Note that previously known as galT'.; galT'; galactose-1-phosphate uridylyltransferase galTa	711536..712231	Mycobacterium tuberculosis H37Rv	887932
YP_177742.1	CDS	galTb	NC_000962.2	<712174	712719	D	SECOND PART; Rv0619, (MTCY19H5.02c), len: 181 aa (probable partial CDS). Probable galTb, second part of galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), highly similar to C-terminal half of other galT proteins e.g. P13212|GAL7_STRLI galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa), FASTA scores: opt: 416, E(): 5.2e-22, (43.0% identity in 186 aa overlap), etc. Cosmid sequence is correct but there may be a frameshift mutation in this region which would allow the two ORFS to be joined. BELONGS TO THE GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE FAMILY 1. Note that previously known as 'galT.; 'galT; galactose-1-phosphate uridylyltransferase GalTb	<712174..712719	Mycobacterium tuberculosis H37Rv	887943
NP_215134.1	CDS	galK	NC_000962.2	712716	713807	D	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase	712716..713807	Mycobacterium tuberculosis H37Rv	887936
NP_215135.1	CDS	Rv0621	NC_000962.2	714202	715266	D	Rv0621, (MTCY20H10.02), len: 354 aa. Possible membrane protein; contains potential membrane spanning regions. Also contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	714202..715266	Mycobacterium tuberculosis H37Rv	887901
NP_215136.2	CDS	Rv0622	NC_000962.2	715370	716317	D	Rv0622, (MTCY20H10.03), len: 315 aa. Possible membrane protein; contains potential membrane spanning region. Shows weak similarity with Mycobacterium tuberculosis hypothetical proteins Rv1804c, Rv1810, etc. Start changed since first submission (-26 aa).; hypothetical protein	715370..716317	Mycobacterium tuberculosis H37Rv	887942
NP_215137.1	CDS	Rv0623	NC_000962.2	716410	716664	D	Rv0623, (MTCY20H10.04), len: 84 aa. Conserved hypothetical protein, highly similar to NP_384911.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (84 aa). Also similar to several Mycobacterium tuberculosis hypothetical proteins e.g MTCY28_2|Rv1740|MTCY28.02|MTCY04C12.25 CONSERVED HYPOTHETICAL PROTEIN (70 aa), FASTA score: (73.5% identity in 68 aa overlap); MTCY4C12_25|Rv0608|MTCY19H5.14c CONSERVED HYPOTHETICAL PROTEIN (81 aa), FASTA score: (73.5 identity in 68 aa overlap); etc.; hypothetical protein	716410..716664	Mycobacterium tuberculosis H37Rv	887970
NP_215138.1	CDS	Rv0624	NC_000962.2	716664	717059	D	Rv0624, (MTCY20H10.05), len: 131 aa. Conserved hypothetical protein, highly similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1741, Rv0609, Rv2759c,Rv0565c, Rv3854c, Rv3083, etc.; hypothetical protein	716664..717059	Mycobacterium tuberculosis H37Rv	887951
NP_215139.1	CDS	Rv0625c	NC_000962.2	717153	717893	R	Rv0625c, (MTCY20H10.06c), len: 246 aa. Probable conserved transmembrane protein, showing similarity with others e.g. CAB61866.1|AL133252 putative integral membrane protein from Streptomyces coelicolor (249 aa). Also similar to Rv1491c|MTCY277_13 from Mycobacterium tuberculosis. Contains potential membrane spanning regions.; transmembrane protein	complement(717153..717893)	Mycobacterium tuberculosis H37Rv	887967
NP_215140.1	CDS	Rv0626	NC_000962.2	718025	718285	D	Rv0626, (MTCY20H10.07), len: 86 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv0596c, Rv3385c, Rv3407,Rv3181c, etc.; hypothetical protein	718025..718285	Mycobacterium tuberculosis H37Rv	887996
NP_215141.1	CDS	Rv0627	NC_000962.2	718282	718689	D	Rv0627, (MTCY20H11.08), len: 135 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv0595c and Rv0665.; hypothetical protein	718282..718689	Mycobacterium tuberculosis H37Rv	887991
NP_215142.1	CDS	Rv0628c	NC_000962.2	718761	719912	R	Rv0628c, (MTCY20H10.09c), len: 383 aa. Conserved hypothetical protein, highly similar to Rv0874c|YZ02_MYCTU|Q10536 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (386 aa), FASTA scores: opt: 2082, E(): 0, (81.5% identity in 383 aa overlap). Also some similarity to P72543|SPU62616_1 HYPOTHETICAL PROTEIN from Synechococcus, FASTA scores: E(): 2.8e-28, (36.6 identity in 265 aa overlap).; hypothetical protein	complement(718761..719912)	Mycobacterium tuberculosis H37Rv	887986
NP_215143.1	CDS	recD	NC_000962.2	720005	721732	R	Rv0629c, (MTCY20H10.10c), len: 575 aa. Probable recD, exonuclease V, alpha chain (exodeoxyribonuclease V, alpha chain) (EC 3.1.11.5) (see citation below), highly similar to other exonucleases e.g. AF157643_3|AAD46809.1|recD Escherichia coli RecD protein homolog from Mycobacterium smegmatis (554 aa); P04993|EX5A_ECOLI|B2819 exodeoxyribonuclease v 67kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V ALPHA CHAIN) from Escherichia coli strain K12 (608 aa), FASTA scores: opt: 512, E(): 1.9e-24, (36.9% identity in 582 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). CONSIST OF THREE SUBUNITS; RECB|Rv0630c, RECC|Rv0631c AND RECD.; exonuclease V alpha chain	complement(720005..721732)	Mycobacterium tuberculosis H37Rv	887999
NP_215144.1	CDS	recB	NC_000962.2	721729	725013	R	Rv0630c, (MTCY20H10.11c), len: 1094 aa. Probable recB, exonuclease V, beta chain (exodeoxyribonuclease V, beta chain) (EC 3.1.11.5) (see citation below), highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kDa polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from Escherichia coli strain K12 (1180 aa), FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICASE FAMILY, UVRD SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c.; exonuclease V beta chain	complement(721729..725013)	Mycobacterium tuberculosis H37Rv	888004
NP_215145.1	CDS	recC	NC_000962.2	725013	728306	R	Rv0631c, (MTCY20H10.12c), len: 1097 aa. Probable recC, exonuclease V, gamma chain (exodeoxyribonuclease V, gamma chain) (EC 3.1.11.5) (see Mizrahi & Andersen 1998), highly similar to other exonucleases e.g. AF157643_1|RecC|AAD46807.1 Escherichia coli RecC protein homolog from Mycobacterium smegmatis (1085 aa); P07648|EX5C_ECOLI|B2822 exodeoxyribonuclease v 125 kDa polypeptide (EC 3.1.11.5) (EXONUCLEASE V GAMMA CHAIN) from Escherichia coli strain K12 (1122 aa), FASTA scores: opt: 954, E(): 0, (29.2% identity in 1109 aa overlap); etc. CONSIST OF THREE SUBUNITS; RECB|Rv0630c, RECC AND RECD|Rv0629c. The transcription of this CDS seems to be activated specifically in host granulomas (see Ramakrishnan et al., 2000).; exonuclease V gamma chain	complement(725013..728306)	Mycobacterium tuberculosis H37Rv	888008
NP_215146.1	CDS	echA3	NC_000962.2	728583	729278	R	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	complement(728583..729278)	Mycobacterium tuberculosis H37Rv	888015
NP_215147.1	CDS	Rv0633c	NC_000962.2	729327	730166	R	Rv0633c, (MTCY20H11.14c), len: 279 aa. Possible exported protein; has hydrophobic stretch at aa 23-41.; hypothetical protein	complement(729327..730166)	Mycobacterium tuberculosis H37Rv	888001
NP_215148.1	CDS	Rv0634c	NC_000962.2	730320	731033	R	Rv0634c, (MTCY20H10.15c), len: 237 aa. Possible glyoxalase II (EC 3.1.2.6), equivalent to NP_302290.1|NC_002677 putative glyoxylase II from Mycobacterium leprae (238 aa); and similar to U00011_3|Y0BK_MYCLE|Q49649 hypothetical 23.9 kDa protein from Mycobacterium leprae (218 aa), FASTA scores: opt: 281, E(): 3.9e-12, (31.8% identity in 201 aa overlap). Also similar to other glyoxalases and metallo-beta-lactamase family proteins e.g. NP_386770.1|NC_003047 PUTATIVE HYDROXYACYLGLUTATHIONE HYDROLASE from Sinorhizobium meliloti (256 aa); etc. Also similar to other putative glyoxylases from Mycobacterium tuberculosis e.g. Rv1637c. BELONGS TO THE GLYOXALASE II FAMILY. COFACTOR: BINDS TWO ZINC IONS.; glyoxalase II	complement(730320..731033)	Mycobacterium tuberculosis H37Rv	888016
YP_177629.1	CDS	Rv0634A	NC_000962.2	731113	731364	D	Rv0634A, len: 83 aa. Hypothetical unknown protein.; hypothetical protein	731113..731364	Mycobacterium tuberculosis H37Rv	3205041
YP_177630.1	CDS	rpmG	NC_000962.2	731712	731879	D	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33	731712..731879	Mycobacterium tuberculosis H37Rv	3205042
NP_215149.1	CDS	Rv0635	NC_000962.2	731930	732406	D	functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA	731930..732406	Mycobacterium tuberculosis H37Rv	888032
NP_215150.1	CDS	Rv0636	NC_000962.2	732393	732821	D	functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB	732393..732821	Mycobacterium tuberculosis H37Rv	888031
NP_215151.1	CDS	Rv0637	NC_000962.2	732825	733325	D	functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC	732825..733325	Mycobacterium tuberculosis H37Rv	888019
YP_177743.1	CDS	secE	NC_000962.2	733737	734222	D	forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE	733737..734222	Mycobacterium tuberculosis H37Rv	888042
NP_215153.1	CDS	nusG	NC_000962.2	734254	734970	D	Modulates Rho-dependent transcription termination; transcription antitermination protein NusG	734254..734970	Mycobacterium tuberculosis H37Rv	888039
NP_215154.1	CDS	rplK	NC_000962.2	735022	735450	D	binds directly to 23S ribosomal RNA; 50S ribosomal protein L11	735022..735450	Mycobacterium tuberculosis H37Rv	888045
NP_215155.1	CDS	rplA	NC_000962.2	735517	736224	D	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1	735517..736224	Mycobacterium tuberculosis H37Rv	888043
NP_215156.1	CDS	mmaA4	NC_000962.2	736298	737203	R	Rv0642c, (MTCY20H10.23c), len: 301 aa. mmaA4, methoxy mycolic acid synthase 4 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44876|AAC44876.1|cmaA methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (298 aa); NP_302280.1|NC_002677 methyl mycolic acid synthase 4 from Mycobacterium leprae (298 aa); and highly similar to others from Mycobacteria e.g. downstream ORF P72027|mmaA3|Rv0643c|MTCY20H10.24c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 3 from Mycobacterium tuberculosis (293 aa).; methoxy mycolic acid synthase	complement(736298..737203)	Mycobacterium tuberculosis H37Rv	888056
NP_215157.1	CDS	mmaA3	NC_000962.2	737268	738149	R	Rv0643c, (MTCY20H10.24c), len: 293 aa. mmaA3, methoxy mycolic acid synthase 3 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44875|AAC44875.1|cmaB methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (289 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa).; methoxy mycolic acid synthase	complement(737268..738149)	Mycobacterium tuberculosis H37Rv	888058
NP_215158.1	CDS	mmaA2	NC_000962.2	738297	739160	R	Rv0644c, (MTCY20H10.25c), len: 287 aa. mmaA2, methoxy mycolic acid synthase 2 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to AAC44874|AAC44874.1|cmaC methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (287 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa). Note that alternative start is at position 739247.; methoxy mycolic acid synthase	complement(738297..739160)	Mycobacterium tuberculosis H37Rv	888061
NP_215159.1	CDS	mmaA1	NC_000962.2	739327	740187	R	Rv0645c, (MTCY20H10.26c), len: 286 aa. mmaA1, methoxy mycolic acid synthase 1 (methyltransferase) (EC 2.1.1.-) (see citations below). Equivalent to NP_302279.1|NC_002677 methyl mycolic acid synthase 1 from Mycobacterium leprae (286 aa); and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis (301 aa).; methoxy mycolic acid synthase	complement(739327..740187)	Mycobacterium tuberculosis H37Rv	888060
NP_215160.1	CDS	lipG	NC_000962.2	740234	741139	R	Rv0646c, (MTCY20H10.27c), len: 301 aa. Probable lipG, lipase/esterase (EC 3.1.-.-), equivalent to NP_302278.1|NC_002677 probable hydrolase from Mycobacterium leprae (304 aa). Also highly similar to various hydrolases, especially lipases e.g. AA61351.1|X88895 carboxyl esterase from Acinetobacter calcoaceticus (312 aa), FASTA scores: opt: 867, E(): 0, (50.2% identity in 279 aa overlap); etc. Also similar to transferases e.g. P77026 MACROLIDE 2'-PHOSPHOTRANSFERASE II from Escherichia coli (279 aa), FASTA scores: E(): 1.3e-14, (32.5% identity in 286 aa overlap). Similar to M. tuberculosis non-heme bromoperoxidases and epoxide hydrolases.; lipase/esterase LipG	complement(740234..741139)	Mycobacterium tuberculosis H37Rv	888065
NP_215161.1	CDS	Rv0647c	NC_000962.2	741151	742617	R	Rv0647c, (MTCY20H10.28c), len: 488 aa. Conserved hypothetical protein, equivalent to NP_302277.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (448 aa). Also showing similarity to a variety of hypothetical ABC1-LIKE proteins or conserved hypothetical proteins e.g. D90908_28|P73627 ABC1-LIKE PROTEIN from Synechocystis (585 aa), FASTA scores: E(): 1.8e-31, (29.1% identity in 474 aa overlap); Q55884 HYPOTHETICAL6 5.0 KD PROTEIN (567 aa), FASTA scores: opt: 583, E(): 5.7e-30, (28.1% identity in 416 aa overlap); etc. Also similar to Rv3197 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis.; hypothetical protein	complement(741151..742617)	Mycobacterium tuberculosis H37Rv	888070
NP_215162.1	CDS	Rv0648	NC_000962.2	742719	746366	D	Rv0648, (MTCY20H10.29), len: 1215 aa. Alpha-mannosidase (EC 3.2.1.-) (see citation below), showing some similarity to hypothetical proteins and various sugar hydrolases e.g. SYCSLRA_6|Q55528 HYPOTHETICAL 1 20.4 kDa PROTEIN from Synechocystis (1042 aa), FASTA scores: opt: 260, E(): 3.6e-08, (23.4% identity in 602 aa overlap); etc. Contains PS00659 Glycosyl hydrolases family 5 signature.; alpha-mannosidase	742719..746366	Mycobacterium tuberculosis H37Rv	888048
YP_177744.1	CDS	fabD2	NC_000962.2	746363	747037	D	Rv0649, (MTCY20H10.30), len: 224 aa. Possible fabD2, malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39), similar to MTFABD|FABD_MYCTU|Q10501|Rv2243 malonyl CoA-acyl carrier protein transacylase from Mycobacterium tuberculosis (302 aa), FASTA scores: opt: 133, E(): 0.074, (31.3% identity in 147 aa overlap).; malonyl CoA-acyl carrier protein transacylase	746363..747037	Mycobacterium tuberculosis H37Rv	888079
NP_215164.1	CDS	Rv0650	NC_000962.2	747037	747945	D	Rv0650, (MTCY20H10.31), len: 302 aa. Possible sugar kinase, highly similar to others e.g. CAB95296.1|AL359779 putative sugar kinase from Streptomyces coelicolor (317 aa); NP_406512.1|NC_003143 putative sugar kinase from Yersinia pestis (290 aa); NP_229269.1|NC_000853 glucokinase from Thermotoga maritima (317 aa); etc. Contains PS01125 ROK family signature. BELONGS TO THE ROK (NAGC/XYLR) FAMILY.; sugar kinase	747037..747945	Mycobacterium tuberculosis H37Rv	888082
NP_215165.1	CDS	rplJ	NC_000962.2	748276	748812	D	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10	748276..748812	Mycobacterium tuberculosis H37Rv	888049
NP_215166.1	CDS	rplL	NC_000962.2	748849	749241	D	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12	748849..749241	Mycobacterium tuberculosis H37Rv	888078
NP_215167.1	CDS	Rv0653c	NC_000962.2	749234	749929	R	Rv0653c, (MTCI376.23, MTCY20H10.34c), len: 231 aa. Possible transcriptional regulator, TetR family, similar in N-terminus to others e.g. CAC03642.1|AL391338 putative TetR-family transcriptional regulator from Streptomyces coelicolor (190 aa); Q51597 CAM REPRESSOR from Pseudomonas putida (186 aa), FASTA scores: opt: 150, E(): 0.00085, (27.8% identity in 97 aa overlap); etc. Also some similarity to Mycobacterium tuberculosis hypothetical transcriptional regulators Rv0681 and Rv1816. Contains probable helix-turn helix motif from aa 27-48 (Score 1156, +3.12 SD).; TetR family transcriptional regulator	complement(749234..749929)	Mycobacterium tuberculosis H37Rv	888087
NP_215168.1	CDS	Rv0654	NC_000962.2	750000	751505	D	Rv0654, (MTCI376.22), len: 501 aa. Probable dioxygenase (EC 1.-.-.-), highly similar to others eg AAK06796.1|AF324838_15|AF324838|SimC5 putative dioxygenase (involved in tetraene formation) from Streptomyces antibioticus (456 aa); CAB56138.1| AL117669 putative dioxygenase from Streptomyces coelicolor (503 aa); T51734 neoxanthin cleavage enzyme (9-cis-epoxy-carotenoid dioxygenase) from Arabidopsis thaliana (538 aa); Q53353 LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE from Pseudomonas paucimobilis (Sphingomonas paucimobilis), FASTA scores: opt: 280, E(): 2.3e-11, (28.5% identity in 523 aa overlap); etc. Also some similarity with Rv0913c|MTCY21C12.07c POSSIBLE DIOXYGENASE from Mycobacterium tuberculosis (501 aa), FASTA score: (29.5% identity in 522 aa overlap).; dioxygenase	750000..751505	Mycobacterium tuberculosis H37Rv	888089
NP_215169.1	CDS	mkl	NC_000962.2	751517	752596	D	Rv0655, (MTCI376.21), len: 359 aa. Possible mkl, ribonucleotide-transport ATP-binding protein ABC transporter (see Braibant et al., 2000), equivalent to P30769|MKL_MYCLE|ML1892 POSSIBLE RIBONUCLEOTIDE TRANSPORT ATP-BINDING PROTEIN from Mycobacterium leprae (347 aa), FASTA scores: opt: 2021, E(): 0, (92.2% identity in 335 aa overlap). Also highly similar to many e.g. AB92896.1|AL356992 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (343 aa); NP_253146.1|NC_002516 probable ATP-binding component of ABC transporter from Pseudomonas aeruginosa (269 aa); P45393|YRBF_ECOLI hypothetical ABC transporter ATP-binding protein from Escherichia coli (269 aa), FASTA scores: opt: 644, E(): 3.4e-33, (38.5% identity in 244 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis ABC transporters e.g. P71747|CYSA|Rv2397c|MTCY253.24 (351 aa), FASTA score: (33.6% identity in 241 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; ribonucleotide ABC transporter ATP-binding protein	751517..752596	Mycobacterium tuberculosis H37Rv	888081
NP_215170.1	CDS	Rv0656c	NC_000962.2	752984	753367	R	Rv0656c, (MTCI376.20), len: 127 aa. Conserved hypothetical protein, showing similarity with proteins from Mycobacterium tuberculosis e.g. Rv2757c, Rv2546, etc.; hypothetical protein	complement(752984..753367)	Mycobacterium tuberculosis H37Rv	888106
NP_215171.1	CDS	Rv0657c	NC_000962.2	753462	753617	R	Rv0657c, (MTCI376.19), len: 51 aa. Conserved hypothetical protein, showing similarity with hypothetical proteins from Mycobacterium tuberculosis e.g. Rv2009|MT2064.1|MTCY39.08c|YW08_MYCTU|Q10848 (80 aa), FASTA scores: opt: 107, E(): 0.0038, (45.8% identity in 48 aa overlap), Rv2871, Rv1560, etc. Also some similarity with AL020958|SC4H8_7 from Streptomyces coelicolor (66 aa), FASTA score: (41.0% identity in 39 aa overlap).; hypothetical protein	complement(753462..753617)	Mycobacterium tuberculosis H37Rv	888077
NP_215172.1	CDS	Rv0658c	NC_000962.2	753693	754409	R	Rv0658c, (MTCI376.18), len: 238 aa. Probable conserved integral membrane protein, equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below), and showing some similarity with P33774|YPRB_ECOLI hypothetical 24.3 kDa protein from Escherichia coli (217 aa), FASTA scores: opt: 174, E(): 5.3e-05, (25.6% identity in 223 aa overlap). Also similar to Rv1863c and Rv0804 from Mycobacterium tuberculosis.; integral membrane protein	complement(753693..754409)	Mycobacterium tuberculosis H37Rv	888102
NP_215173.1	CDS	Rv0659c	NC_000962.2	754685	754993	R	Rv0659c, (MTCI376.17), len: 102 aa. Conserved hypothetical protein, weakly similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1942c, Rv1495, etc.; hypothetical protein	complement(754685..754993)	Mycobacterium tuberculosis H37Rv	888134
NP_215174.1	CDS	Rv0660c	NC_000962.2	754980	755225	R	Rv0660c, (MTCI376.16), len: 81 aa. Conserved hypothetical protein, showing some similarity to AF016485_130 from Halobacterium sp (100 aa), FASTA scores: (32.4% identity in 74 aa overlap).; hypothetical protein	complement(754980..755225)	Mycobacterium tuberculosis H37Rv	888141
NP_215175.1	CDS	Rv0661c	NC_000962.2	755335	755772	R	Rv0661c, (MTCI376.15), len: 145 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv2863|MTV003.09|MTV003_7 (126 aa), FASTA scores: E(): 0.00087, (30.4% identity in 125 aa overlap), Rv0749|MTV041.23 (163 aa); Rv0277c, Rv2530c, etc.; hypothetical protein	complement(755335..755772)	Mycobacterium tuberculosis H37Rv	888143
NP_215176.1	CDS	Rv0662c	NC_000962.2	755769	756137	R	Rv0662c, (MTCI376.14), len: 133 aa. Conserved hypothetical protein, showing weak similarity with other hypothetical proteins from Mycobacterium tuberculosis e.g. Rv2871, Rv1241, Rv2550c, etc.; hypothetical protein	complement(755769..756137)	Mycobacterium tuberculosis H37Rv	888117
NP_215177.1	CDS	atsD	NC_000962.2	756137	758500	D	Rv0663, (MTCI376.13c), len: 787 aa. Possible atsD, arylsulfatase (EC 3.1.6.1), similar to others e.g. P5169|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 653, E(): 0, (33.1% identity in 544 aa overlap); etc. Also similar to P95059|MTCY210.30|ATSA|Rv0711|MTCY210.30 from Mycobacterium tuberculosis (787 aa), FASTA score: (38.9% identity in 769 aa overlap); and other arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c|ATSB (970 aa), Rv0711, etc. Contains PS00523 Sulfatases signature 1. BELONGS TO THE SULFATASE FAMILY.; arylsulfatase AtsD	756137..758500	Mycobacterium tuberculosis H37Rv	888144
NP_215178.1	CDS	Rv0664	NC_000962.2	758532	758804	D	Rv0664, (MTCI376.12c), len: 90 aa. Hypothetical unknown protein.; hypothetical protein	758532..758804	Mycobacterium tuberculosis H37Rv	888146
NP_215179.1	CDS	Rv0665	NC_000962.2	758801	759139	D	Rv0665, (MTCI376.11c), len: 112 aa. Conserved hypothetical protein, similar to Rv0627 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (135 aa), and showing similarity with Rv0595c.; hypothetical protein	758801..759139	Mycobacterium tuberculosis H37Rv	888149
NP_215180.1	CDS	Rv0666	NC_000962.2	759136	759309	D	Rv0666, (MTCI376.10c), len: 57 aa. Possible membrane protein; has hydrophobic stretch at aa 29-47.; hypothetical protein	759136..759309	Mycobacterium tuberculosis H37Rv	888158
NP_215181.1	CDS	rpoB	NC_000962.2	759807	763325	D	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta	759807..763325	Mycobacterium tuberculosis H37Rv	888164
NP_215182.1	CDS	rpoC	NC_000962.2	763370	767320	D	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta'	763370..767320	Mycobacterium tuberculosis H37Rv	888177
NP_215183.1	CDS	Rv0669c	NC_000962.2	767684	769597	R	Rv0669c, (MTCI376.05), len: 637 aa. Possible hydrolase (EC 3.-.-.-), highly similar to various hydrolases (N-terminus shorter) e.g. BAA88409.1|AB028646 alkaline ceramidase from Pseudomonas aeruginosa (670 aa,) FASTA scores: opt: 1490, E(): 0, (41.2% identity in 651 aa overlap); NP_063946.1|NM_019893 mitochondrial ceramidase from Homo sapiens (761 aa); P_446098.1|NM_053646 N-acylsphingosine amidohydrolase 2 from Rattus norvegicus (761 aa); BAB09641.1|AB016885 neutral ceramidase from Arabidopsis thaliana (705 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hydrolase	complement(767684..769597)	Mycobacterium tuberculosis H37Rv	888181
NP_215184.1	CDS	end	NC_000962.2	769792	770550	D	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV	769792..770550	Mycobacterium tuberculosis H37Rv	888190
NP_215185.1	CDS	lpqP	NC_000962.2	770582	771424	D	Rv0671, (MTCI376.03c), len: 280 aa. Possible lpqP, conserved lipoprotein, similar to U00012|B1308_F2_43|Q49658 from Mycobacterium leprae (302 aa), FASTA scores: opt: 449, E(): 2.4e-22, (37.6% identity in 242 aa overlap). Also highly similar to lpqC|Rv3298c|MTCY71.38c PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (304 aa). Also similar to a large variety of proteins including various esterases and poly(3-hydroxyalkanoate) depolymerases, e.g. NP_249234.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (322 aa); C-terminus of AAD45376.1|AF164516_1|AF164516 cinnamoyl ester hydrolase EstA from Piromyces equi (536 aa); part of P52090|PHA1_PSELE POLY(3-HYDROXYALKANOATE) DEPOLYMERASE C PRECURSOR from Pseudomonas lemoignei (414 aa); CAC10310.1|AL442629 putative secreted protein from Streptomyces coelicolor (348 aa); etc. Has a 17 aa signal sequence and contains appropriately positioned (PS00013) Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LpqP	770582..771424	Mycobacterium tuberculosis H37Rv	888194
NP_215186.1	CDS	fadE8	NC_000962.2	771484	773112	D	Rv0672, (MTCI376.02c), len: 545 aa. Probable fadE8, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAC33951.1|AL589708 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (557 aa); P33224|AIDB_ECOLI|B4187 aidb protein (ACYL-COA DEHYDROGENASES FAMILY) from Escherichia coli strain K12 (546 aa), FASTA scores: opt: 1369, E(): 0, (44.1% identity in 524 aa overlap); etc. Also similar to several other M. tuberculosis proteins e.g. Rv0154cRv0154c|MTCI5.28c FASTA score: (26.3% identity in 342 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 2 (PS00073). BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE8	771484..773112	Mycobacterium tuberculosis H37Rv	888198
NP_215187.1	CDS	echA4	NC_000962.2	773123	774061	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	773123..774061	Mycobacterium tuberculosis H37Rv	888175
NP_215188.1	CDS	Rv0674	NC_000962.2	774064	774786	D	Rv0674, (MTV040.02), len: 240 aa. Conserved hypothetical protein, highly similar to AC13063.1|AL445503 conserved hypothetical protein from Streptomyces coelicolor (268 aa); and similar to NP_438100.1|NC_003078 putative regulator of phenylacetic acid degradation ArsR family protein from Sinorhizobium meliloti (306 aa) and other proteins e.g. AB011837|AB011837_13 hypothetical protein from Bacillus halodurans (298 aa), FASTA scores: opt: 148, E(): 0.0081, (25.1% identity in 235 aa overlap); etc. TBparse score is 0.915.; hypothetical protein	774064..774786	Mycobacterium tuberculosis H37Rv	888203
YP_177745.1	CDS	echA5	NC_000962.2	774783	775574	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	774783..775574	Mycobacterium tuberculosis H37Rv	888222
NP_215190.1	CDS	mmpL5	NC_000962.2	775586	778480	R	Rv0676c, (MTV040.04c), len: 964 aa. Probable mmpL5, conserved transmembrane transport protein (see Tekaia et al., 1999), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. MTV037_14, MTCY98_8, MTCY20G9_34, MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19, etc. Also similar to other Mycobacterial mmpl proteins e.g. P54881|MML4_MYCLE PUTATIVE MEMBRANE PROTEIN MMPL4 from Mycobacterium leprae (959 aa), FASTA scores: opt: 3991, E(): 0, (62.8% identity in 933 aa overlap); etc. BELONGS TO THE MMPL FAMILY. TBparse score is 0.884.; transmembrane transport protein MmpL5	complement(775586..778480)	Mycobacterium tuberculosis H37Rv	888219
NP_215191.1	CDS	mmpS5	NC_000962.2	778477	778905	R	Rv0677c, (MTV040.05c), len: 142 aa. Possible mmpS5, conserved membrane protein (see Tekaia et al., 1999), highly similar to other Mycobacterial proteins e.g. P54880|MMS4_MYCLE PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 443, E(): 1.4e-23, (47.1% identity in 155 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis. BELONGS TO THE MMPS FAMILY. TBparse score is 0.901.; hypothetical protein	complement(778477..778905)	Mycobacterium tuberculosis H37Rv	888233
NP_215192.1	CDS	Rv0678	NC_000962.2	778990	779487	D	Rv0678, (MTV040.06), len: 165 aa. Conserved hypothetical protein, showing weak similarity with AL049754|SCH10_10 hypothetical protein from Streptomyces coelicolor (152 aa), FASTA scores: opt: 149, E(): 0.0018, (22.9% identity in 140 aa overlap). TBparse score is 0.910.; hypothetical protein	778990..779487	Mycobacterium tuberculosis H37Rv	888235
NP_215193.1	CDS	Rv0679c	NC_000962.2	779543	780040	R	Rv0679c, (MTV040.07c), len: 165 aa. Conserved hypothetical Thr-rich protein, similar in part to neighboring ORF Rv0680c (124 aa), FASTA score: (35.1% identity in 131 aa overlap); and Rv0314c (220 aa). Contains probable N-terminal signal sequence. TBparse score is 0.894.; putative threonine rich protein	complement(779543..780040)	Mycobacterium tuberculosis H37Rv	888230
NP_215194.1	CDS	Rv0680c	NC_000962.2	780042	780416	R	Rv0680c, (MTV040.08c), len: 124 aa. Possible conserved transmembrane protein, showing similarity with C-terminal part of Rv0314c|Z96800|MTCY63.19c conserved hypothetical protein from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 175, E(): 2.2e-05, (31.4% identity in 102 aa overlap). Also some similarity to upstream ORF Rv0679c|MTV040.07c CONSERVED HYPOTHETICAL THREONINE RICH PROTEIN (124 aa), FASTA score: (35.1% identity in 131 aa overlap). Contains probable N-terminal signal sequence. TBparse score is 0.877.; transmembrane protein	complement(780042..780416)	Mycobacterium tuberculosis H37Rv	888229
NP_215195.1	CDS	Rv0681	NC_000962.2	780721	781311	D	Rv0681, (MTV040.09), len: 196 aa. Probable transcription regulator, TetR family, similar to others and especially many tetracycline repressors e.g. T34657 probable transcription regulator from Streptomyces coelicolor (189 aa); AF0278|AF027868_40|NP_389788.1|NC_000964 yobS regulator from Bacillus subtilis (191 aa), FASTA scores: opt: 213, E(): 1.6e-07, (28.8% identity in 153 aa overlap); P09164|TER4_ECOLI TETRACYCLINE REPRESSOR PROTEIN from Escherichia coli (217 aa), FASTA scores: opt: 145, E(): 0.0068, (39.0% identity in 59 aa overlap); etc. Contains helix-turn-helix motif at aa 28-49 (Score 1020, +2.66 SD). TBparse score is 0.897.; TetR family transcriptional regulator	780721..781311	Mycobacterium tuberculosis H37Rv	888239
NP_215196.1	CDS	rpsL	NC_000962.2	781560	781934	D	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12	781560..781934	Mycobacterium tuberculosis H37Rv	888259
NP_215197.1	CDS	rpsG	NC_000962.2	781934	782404	D	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7	781934..782404	Mycobacterium tuberculosis H37Rv	888245
YP_177746.1	CDS	fusA1	NC_000962.2	782485	784590	D	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G	782485..784590	Mycobacterium tuberculosis H37Rv	888240
NP_215199.1	CDS	tuf	NC_000962.2	784821	786011	D	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu	784821..786011	Mycobacterium tuberculosis H37Rv	888262
NP_215200.1	CDS	Rv0686	NC_000962.2	786149	786946	D	Rv0686, (MTCY210.03), len: 265 aa. Probable membrane protein, with hydrophobic N-terminus. TBparse score is 0.908.; hypothetical protein	786149..786946	Mycobacterium tuberculosis H37Rv	888271
NP_215201.1	CDS	fabG	NC_000962.2	787099	787926	D	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase	787099..787926	Mycobacterium tuberculosis H37Rv	888279
NP_215202.1	CDS	Rv0688	NC_000962.2	787940	789160	D	Rv0688, (MTCY210.05), len: 406 aa. Putative ferredoxin reductase (EC 1.-.-.-), highly similar to others e.g. BAB55881.1|AB054975 ferredoxin reductase from Terrabacter sp. DBF63 (410 aa); CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa); PPU24215_8|Q51973 P-CUMATE DIOXYGENASE FERREDOXIN REDUCTASE SUBUNIT from Pseudomonas putida (402 aa), FASTA scores: opt: 738, E(): 0, (38.8% identity in 330 aa overlap); etc. Also similar to Rv0253 and Rv1869c from Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL TYPE FERREDOXIN FAMILY. TBparse score is 0.909.; putative ferredoxin reductase	787940..789160	Mycobacterium tuberculosis H37Rv	888280
NP_215203.1	CDS	Rv0689c	NC_000962.2	789157	789411	R	Rv0689c, (MTCY210.06c), len: 84 aa. Hypothetical unknown protein. TBparse score is 0.879.; hypothetical protein	complement(789157..789411)	Mycobacterium tuberculosis H37Rv	888283
NP_215204.1	CDS	Rv0690c	NC_000962.2	790024	791073	R	Rv0690c, (MTCY210.07c), len: 349 aa. Conserved hypothetical protein, showing similarity with NP_386956.1|NC_003047 CONSERVED HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (358 aa); NP_356573.1|NC_003063 AGR_L_1570p from Agrobacterium tumefaciens (346 aa); NP_421938.1|NC_002696 conserved hypothetical protein from Caulobacter crescentus (370 aa). TBparse score is 0.918.; hypothetical protein	complement(790024..791073)	Mycobacterium tuberculosis H37Rv	888292
NP_215205.1	CDS	Rv0691c	NC_000962.2	791070	791666	R	Rv0691c, (MTCY210.08c), len: 198 aa. Probable transcriptional regulator, highly similar to AAC77476.1|U17129 unknown protein from Rhodococcus erythropolis (185 aa); and showing similarity with putative regulatory proteins eg STMTCREP_1|TCMR_STRGA|P39885 tetracenomycin c transcriptional repressor from Streptomyces glaucescens (226 aa), FASTA scores: opt: 178, E(): 8.5e-06, (27.9% identity in 201 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and probable helix-turn helix motifs from aa 34-55 (Score 1100, +2.93 SD) and 151-172 (Score 1124, +3.02 SD). TBparse score is 0.934.; transcriptional regulatory protein	complement(791070..791666)	Mycobacterium tuberculosis H37Rv	888296
NP_215206.1	CDS	Rv0692	NC_000962.2	791831	792160	D	Rv0692, (MTCY210.09), len: 109 aa. Conserved hypothetical protein, highly similar to U17129|RSU17129_3|AAC77477.1 unknown protein from Rhodococcus erythropolis (95 aa), FASTA scores: opt: 393, E(): 8.8e-22, (68.2% identity in 88 aa overlap).; hypothetical protein	791831..792160	Mycobacterium tuberculosis H37Rv	888285
NP_215207.1	CDS	pqqE	NC_000962.2	792157	793332	D	Rv0693, (MTCY210.10), len: 391 aa. Probable pqqE (alternate gene name: pqqIII), coenzyme PQQ synthesis protein E, similar to others AE001109_9|O30258|PQQE COENZYME PQQ SYNTHESIS PROTEIN from Archaeoglobus fulgidus (375 aa), FASTA scores: E(): 1.6e-16, (28.1% identity in 377 aa overlap); PQQE_ACICA|P07782 coenzyme pqq synthesis protein e from Acinetobacter calcoaceticus (384 aa), FASTA scores: opt: 302, E(): 1.8e-12, (23.9% identity in 377 aa overlap); etc. Also similar to C-terminus of heme biosynthesis proteins e.g. O28270|AF2009 HEME BIOSYNTHESIS PROTEIN (NIRJ-2) from Archaeoglobus fulgidus (468 aa). Note that also highly similar to U17129|RSU17129_4|AAC77478.1 unknown protein from Rhodococcus erythropolis (405 aa), FASTA scores: opt: 1997, E(): 0, (73.3% identity in 390 aa overlap). COULD BELONG TO THE MOAA / NIFB / PQQE FAMILY. TBparse score is 0.919.; pqqIII; coenzyme PQQ synthesis protein E	792157..793332	Mycobacterium tuberculosis H37Rv	888302
NP_215208.1	CDS	lldD1	NC_000962.2	793335	794525	D	Rv0694, (MTCY210.11), len: 396 aa. Possible lldD1, L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3), similar to NP_302368.1|NC_002677 L-lactate dehydrogenase from Mycobacterium leprae (414 aa). Also similar to others e.g. NP_384560.1|NC_003047 PUTATIVE L-LACTATE DEHYDROGENASE (CYTOCHROME) PROTEIN from Sinorhizobium meliloti (403 aa); NP_251072.1|NC_002516 L-lactate dehydrogenase from Pseudomonas aeruginosa (383 aa); P33232|LLDD_ECOLI L-lactate dehydrogenase (cytochrome) from Escherichia coli strain K12 (396 aa), FASTA scores: opt: 697, E(): 0, (34.5 identity in 380 aa overlap); etc; and also similar to other oxidoreductases. Note that also highly similar to RSU17129_5|AAC77479.1|U17129 unknown protein from Rhodococcus erythropolis (392 aa), FASTA scores: opt: 2006, E(): 0, (74.1% identity in 386 aa overlap). Also similar to lldD2|Rv1872c|MTCY180.46|MTCY359.01 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) from Mycobacterium tuberculosis (414 aa). BELONGS TO THE FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASES FAMILY. TBparse score is 0.918.; L-lactate dehydrogenase (cytochrome) LldD1	793335..794525	Mycobacterium tuberculosis H37Rv	888310
NP_215209.1	CDS	Rv0695	NC_000962.2	794715	795470	D	Rv0695, (MTCY210.12), len: 251 aa. Conserved hypothetical protein, similar to many creatinine amidohydrolases or hypothetical proteins e.g. NP_443048.1|NC_000911 creatinine amidohydrolase from Synechococcus sp. PCC 6803 (273 aa); NP_466169.1|NC_003210 protein similar to creatinine amidohydrolase from Listeria monocytogenes (249 aa); T35153|SC5A7.04c hypothetical protein from Streptomyces coelicolor (273 aa); etc. Note that highly similar to RSU17129_10|AAC77474.1|U17129 unknown protein from Rhodococcus erythropolis (230 aa), FASTA scores: opt: 693, E(): 0, (55.7% identity in 237 aa overlap).; hypothetical protein	794715..795470	Mycobacterium tuberculosis H37Rv	888314
NP_215210.1	CDS	Rv0696	NC_000962.2	795519	796931	D	Rv0696, (MTCY210.13), len: 470 aa. Probable membrane sugar transferase (EC 2.-.-.-), similar (except in N-terminus) to NP_069157.1|NC_000917 glycosyl transferase from Archaeoglobus fulgidus (324 aa); NP_279985.1|NC_002607 rhamnosyl transferase from Halobacterium sp. NRC-1 (299 aa); NP_059113.1|NM_017417 polypeptide N-acetylgalactosaminyltransferase 8 from (637 aa). Note that also highly similar to P46370|YTH1_RHOER HYPOTHETICAL 55.3 KDA PROTEIN from Rhodococcus erythropolis (513 aa), FASTA scores: opt: 1514, E(): 0, (51.8% identity in 469 aa overlap). TBparse score is 0.924.; membrane sugar transferase	795519..796931	Mycobacterium tuberculosis H37Rv	888307
NP_215211.1	CDS	Rv0697	NC_000962.2	796933	798372	D	Rv0697, (MTCY210.14, unknown), len: 479 aa. Probable dehydrogenase (EC 1.-.-.-), highly similar to P30772|YTUR_MYCLE HYPOTHETICAL 24 kDa PROTEIN from Mycobacterium leprae (220 aa), FASTA scores: opt: 557, E(): 1.7e-28, (46.2% identity in 223 aa overlap). Also highly similar to P46371|YTH2_RHOER HYPOTHETICAL 53.0 KDA GMC-TYPE OXIDOREDUCTASE from Rhodococcus erythropolis (493 aa); and similar to many dehydrogenases e.g. NP_250814.1|NC_002516 probable dehydrogenase from Pseudomonas aeruginosa (545 aa); BAA13145.1|D86622 FAD dependent L-sorbose dehydrogenase from Gluconobacter oxydans (531 aa); etc. Also similar to Rv1279 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis.; dehydrogenase	796933..798372	Mycobacterium tuberculosis H37Rv	888316
NP_215212.1	CDS	Rv0698	NC_000962.2	798833	799444	D	Rv0698, (MTCY210.15), len: 203 aa. Conserved hypothetical protein, highly similar to C-terminus of Rv3639c|MTY15C10.12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (188 aa), FASTA scores: E(): 2.1e-07, (54.8% identity in 73 aa overlap).; hypothetical protein	798833..799444	Mycobacterium tuberculosis H37Rv	888327
NP_215213.1	CDS	Rv0699	NC_000962.2	799629	799850	D	Rv0699, (MTCY210.17), len: 73 aa. Hypothetical unknown protein.; hypothetical protein	799629..799850	Mycobacterium tuberculosis H37Rv	888335
NP_215214.1	CDS	rpsJ	NC_000962.2	800487	800792	D	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10	800487..800792	Mycobacterium tuberculosis H37Rv	888331
NP_215215.1	CDS	rplC	NC_000962.2	800809	801462	D	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3	800809..801462	Mycobacterium tuberculosis H37Rv	888343
NP_215216.1	CDS	rplD	NC_000962.2	801462	802133	D	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4	801462..802133	Mycobacterium tuberculosis H37Rv	888345
NP_215217.1	CDS	rplW	NC_000962.2	802133	802435	D	binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23	802133..802435	Mycobacterium tuberculosis H37Rv	888353
NP_215218.1	CDS	rplB	NC_000962.2	802528	803370	D	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2	802528..803370	Mycobacterium tuberculosis H37Rv	888341
NP_215219.1	CDS	rpsS	NC_000962.2	803411	803692	D	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19	803411..803692	Mycobacterium tuberculosis H37Rv	888356
NP_215220.1	CDS	rplV	NC_000962.2	803689	804282	D	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22	803689..804282	Mycobacterium tuberculosis H37Rv	888359
NP_215221.1	CDS	rpsC	NC_000962.2	804282	805106	D	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3	804282..805106	Mycobacterium tuberculosis H37Rv	888357
NP_215222.1	CDS	rplP	NC_000962.2	805110	805526	D	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16	805110..805526	Mycobacterium tuberculosis H37Rv	888377
NP_215223.1	CDS	rpmC	NC_000962.2	805526	805759	D	one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29	805526..805759	Mycobacterium tuberculosis H37Rv	888374
NP_215224.1	CDS	rpsQ	NC_000962.2	805756	806166	D	primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17	805756..806166	Mycobacterium tuberculosis H37Rv	888391
NP_215225.1	CDS	atsA	NC_000962.2	806335	808698	D	Rv0711, (MTCY210.30), len: 787 aa. Possible atsA, arylsulfatase (EC 3.1.6.1), similar to others e.g. P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 439, E(): 2.9e-21, (30.8% identity in 552 aa overlap); etc. Also similar to other hypothetical arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c, Rv0663, etc. Contains PS00523 Sulfatases signature 1, and PS00149 Sulfatases signature 2. BELONGS TO THE SULFATASE FAMILY.; arylsulfatase AtsA	806335..808698	Mycobacterium tuberculosis H37Rv	888394
NP_215226.1	CDS	Rv0712	NC_000962.2	808746	809645	D	Rv0712, (MTCY210.31), len: 299 aa. Conserved hypothetical protein, similar to others e.g. NP_106128.1|NC_002678 hypothetical protein from Mesorhizobium loti (372 aa); D90901_33|P72841 HYPOTHETICAL 48.1 kDa PROTEIN from Synechocystis sp (410 aa), FASTA scores: E(): 1.1e-07, (28.8% identity in 299 aa overlap); etc. Slight similarity to carboxykinases. Similar to C-terminal part of Rv3703c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (425 aa).; hypothetical protein	808746..809645	Mycobacterium tuberculosis H37Rv	888346
NP_215227.1	CDS	Rv0713	NC_000962.2	809946	810887	D	Rv0713, (MTCY210.32), len: 313 aa. Probable conserved transmembrane protein, similar to Rv3435c|MTCY77_7|O06252 from Mycobacterium tuberculosis (284 aa), FASTA scores: opt: 557, E(): 2.1e-29, (35.8% identity in 282 aa overlap); MLCB2492_12|O32991 HYPOTHETICAL 10.7 kDa PROTEIN from Mycobacterium leprae (95 aa).; transmembrane protein	809946..810887	Mycobacterium tuberculosis H37Rv	888405
NP_215228.1	CDS	rplN	NC_000962.2	811373	811741	D	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14	811373..811741	Mycobacterium tuberculosis H37Rv	888411
NP_215229.1	CDS	rplX	NC_000962.2	811742	812059	D	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24	811742..812059	Mycobacterium tuberculosis H37Rv	888421
NP_215230.1	CDS	rplE	NC_000962.2	812059	812622	D	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5	812059..812622	Mycobacterium tuberculosis H37Rv	888400
YP_177747.1	CDS	rpsN	NC_000962.2	812627	812812	D	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14	812627..812812	Mycobacterium tuberculosis H37Rv	888414
NP_215232.1	CDS	rpsH	NC_000962.2	812976	813374	D	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8	812976..813374	Mycobacterium tuberculosis H37Rv	888424
NP_215233.1	CDS	rplF	NC_000962.2	813398	813937	D	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6	813398..813937	Mycobacterium tuberculosis H37Rv	888433
NP_215234.1	CDS	rplR	NC_000962.2	813940	814308	D	binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18	813940..814308	Mycobacterium tuberculosis H37Rv	888457
NP_215235.1	CDS	rpsE	NC_000962.2	814328	814990	D	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5	814328..814990	Mycobacterium tuberculosis H37Rv	888465
NP_215236.1	CDS	rpmD	NC_000962.2	814993	815190	D	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30	814993..815190	Mycobacterium tuberculosis H37Rv	888505
NP_215237.1	CDS	rplO	NC_000962.2	815190	815630	D	late assembly protein; 50S ribosomal protein L15	815190..815630	Mycobacterium tuberculosis H37Rv	888531
NP_215238.1	CDS	sppA	NC_000962.2	815663	817534	D	Rv0724, (MTCY210.43), len: 623 aa. Possible sppA, protease IV (endopeptidase IV) (EC 3.4.21.-), equivalent (but longer 23 aa) to MLCB2492_24|O33003 ENDOPEPTIDASE IV from Mycobacterium leprae (602 aa). Also similar to others e.g. NP_419743.1|NC_002696 signal peptide peptidase SppA from Caulobacter crescentus (594 aa); P08395|SPPA_ECOLI|B1766 protease IV (endopeptidase) from Escherichia coli strain K-12 (618 aa), FASTA scores: opt: 582, E(): 8.9e-27, (34.1% identity in 525 aa overlap); etc. BELONGS TO PEPTIDASE FAMILY S49.; protease IV SppA	815663..817534	Mycobacterium tuberculosis H37Rv	888535
YP_177631.1	CDS	Rv0724A	NC_000962.2	817531	>817866	R	Rv0724A, len: 111 aa. Similarity suggests that this CDS should be continuation of Rv0725c but we can find no frame-shift to account for this. Possible extended protein is very similar to other hypothetical Mycobacterium tuberculosis proteins e.g. Rv1729c|Z81360_12 (312 aa), FASTA scores: opt: 399, E(): 2e-19, (58.7% identity in 109 aa overlap); Rv0731c, Rv0726c, etc. Frame-shift could occur at nt 817866. Same sequence for strain CDC1551 and Mycobacterium bovis.; hypothetical protein	complement(817531..>817866)	Mycobacterium tuberculosis H37Rv	3205058
NP_215239.1	CDS	Rv0725c	NC_000962.2	817539	818444	R	Rv0725c, (MTCY210.44c), len: 301 aa. Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0726c, Rv0731c, Rv3399, etc, e.g. Y893_MYCTU|Q10552|Rv0893C hypothetical 36.1 kDa protein cy31.21c (325 aa), FASTA scores: opt: 600, E(): 3.9e-32, (43.8% identity in 219 aa overlap).; hypothetical protein	complement(817539..818444)	Mycobacterium tuberculosis H37Rv	888447
NP_215240.1	CDS	Rv0726c	NC_000962.2	818537	819640	R	Rv0726c, (MTCY210.45c), len: 367 aa. Conserved hypothetical protein, highly similar to other conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Q10552|Y893_MYCTU|Rv0893c|MT0917|MTCY31.21c (325 aa), FASTA scores: opt: 646, E(): 0, (38.3% identity in 329 aa overlap); Rv0731c|MTV041.05c (318 aa), Rv3399, etc. Also similar to proteins from Mycobacterium leprae and other organisms e.g. T35930 hypothetical protein SC9B5.10 from Streptomyces coelicolor (303 aa).; hypothetical protein	complement(818537..819640)	Mycobacterium tuberculosis H37Rv	888552
NP_215241.1	CDS	fucA	NC_000962.2	819843	820499	R	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose-phosphate aldolase	complement(819843..820499)	Mycobacterium tuberculosis H37Rv	888550
NP_215242.1	CDS	serA2	NC_000962.2	820496	821476	R	Rv0728c, (MTV041.02c), len: 326 aa. Possible serA2, D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95), similar to others e.g. AF0278|AF027868_5|YoaD D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (344 aa), FASTA scores: opt: 594, E(): 3.1e-31, (35.9% identity in 309 aa overlap); etc. Also similar to Rv2996c|MTV012.10|SERA1 D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis (528 aa). TBparse score is 0.882.; D-3-phosphoglycerate dehydrogenase	complement(820496..821476)	Mycobacterium tuberculosis H37Rv	888555
NP_215243.1	CDS	xylB	NC_000962.2	821507	822853	D	Rv0729, (MTV041.03), len: 448 aa. Possible xylB, D-xylulose-kinase (xylulokinase) (EC 2.7.1.17). C-terminus highly similar to AAD09880.1|U77912 unknown protein from Mycobacterium bovis (102 aa); and N-terminus highly similar to T45387|Z98756|MLCB2492_25 hypothetical protein from Mycobacterium leprae (110 aa), FASTA scores: opt: 427, E(): 1.1e-19, (60.9% identity in 110 aa overlap). Also similar to xylA/xylB genes from various bacterial species e.g. AAC26499.1|AF045245 D-xylulose-kinase from Klebsiella pneumoniae (487 aa); NP_418021.1|NC_000913 xylulokinase from Escherichia coli strain K12 (484 aa), FASTA scores: opt: 260, E(): 7.5e-09, (25.9% identity in 478 aa overlap); etc. Also similar to Rv3696c|glpK PROBABLE GLYCEROL KINASE (EC 2.7.1.30) from Mycobacterium tuberculosis (517 aa). BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY. TBparse score is 0.895.; D-xylulose kinase XylB	821507..822853	Mycobacterium tuberculosis H37Rv	888548
NP_215244.1	CDS	Rv0730	NC_000962.2	822866	823594	D	Rv0730, (MTV041.04), len: 242 aa. Conserved hypothetical protein, only equivalent to Z98756|MLCB2492_26 HYPOTHETICAL PROTEIN from Mycobacterium leprae (227 aa), FASTA scores: opt: 1180, E(): 0, (83.5% identity in 218 aa overlap). TBparse score is 0.899.; hypothetical protein	822866..823594	Mycobacterium tuberculosis H37Rv	888558
NP_215245.1	CDS	Rv0731c	NC_000962.2	823683	824639	R	Rv0731c, (MTV041.05c), len: 318 aa. Conserved hypothetical protein, highly similar to other conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0726c|MTCY210.45c (367 aa), FASTA score: (60.9% identity in 317 aa overlap); Rv3399, Rv1729c, etc. TBparse score is 0.880.; hypothetical protein	complement(823683..824639)	Mycobacterium tuberculosis H37Rv	888556
NP_215246.1	CDS	secY	NC_000962.2	824800	826125	D	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY	824800..826125	Mycobacterium tuberculosis H37Rv	888559
NP_215247.1	CDS	adk	NC_000962.2	826122	826667	D	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase	826122..826667	Mycobacterium tuberculosis H37Rv	888567
YP_177748.1	CDS	mapA	NC_000962.2	826670	827470	D	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase	826670..827470	Mycobacterium tuberculosis H37Rv	888564
NP_215249.1	CDS	sigL	NC_000962.2	827543	828076	D	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and secreted or membrane proteins; RNA polymerase sigma factor SigL	827543..828076	Mycobacterium tuberculosis H37Rv	888609
NP_215250.1	CDS	Rv0736	NC_000962.2	828140	828892	D	Rv0736, (MTV041.10), len: 250 aa. Probable conserved membrane protein, showing weak similarity with AL133469|SCM10_32 putative membrane protein from Streptomyces coelicolor (216 aa), FASTA scores: opt: 180, E(): 0.00018, (34.3% identity in 216 aa overlap). TBparse score is 0.911.; hypothetical protein	828140..828892	Mycobacterium tuberculosis H37Rv	888611
NP_215251.1	CDS	Rv0737	NC_000962.2	829207	829704	D	Rv0737, (MTV041.11), len: 165 aa. Possible transcriptional regulator, similar to others e.g. BAB69161.1|AB070937 regulator protein from Streptomyces avermitilis (169 aa); NP_419731.1|NC_002696 transcriptional regulator MarR family from Caulobacter crescentus (148 aa) (homology only at C-terminus); etc. Also shows weak similarity to AB0014|AB001488_14 hypothetical protein from Bacillus subtilis (164 aa), FASTA scores: opt: 163, E(): 9.3e-05, (32.8% identity in 116 aa overlap), which is similar to slyY gene of S. typhimurium required for survival in macrophage. Contains possible helix-turn helix motif from aa 73-94 (Score 1138, +3.06 SD). TBparse score is 0.888.; transcriptional regulatory protein	829207..829704	Mycobacterium tuberculosis H37Rv	888619
NP_215252.1	CDS	Rv0738	NC_000962.2	830062	830610	D	Rv0738, (MTV041.12), len: 182 aa. Conserved hypothetical protein, showing weak similarity with hypothetical proteins from Mycobacterium tuberculosis: Rv1727|MTCY04C12.12 (189 aa); MTY13D12_7|Z80343 hypothetical protein from Mycobacterium tuberculosis (194 aa), FASTA scores: opt: 172, E(): 0.0004, (24.2% identity in 178 aa overlap); and C-terminus of Rv0576. TBparse score is 0.886.; hypothetical protein	830062..830610	Mycobacterium tuberculosis H37Rv	888620
NP_215253.1	CDS	Rv0739	NC_000962.2	830855	831661	D	Rv0739, (MTV041.13), len: 268 aa. Conserved hypothetical protein, showing some similarity to Mycobacterium tuberculosis proteins Rv0026 (448 aa), FASTA score: (37.6% identity in 101 aa overlap)and Rv0025 (120 aa), FASTA score: (32.4% identity in 142 aa overlap). TBparse score is 0.942.; hypothetical protein	830855..831661	Mycobacterium tuberculosis H37Rv	888622
NP_215254.1	CDS	Rv0740	NC_000962.2	831776	832303	D	Rv0740, (MTV041.14), len: 175 aa. Conserved hypothetical protein; C-terminus (possibly part of truncated IS1557) shows nearly perfect identity to Rv0750|MTV041_24 (81 aa), FASTA score: (92.6% identity in 81 aa overlap). Also shows weak similarity to MTV007_5 hypothetical protein from Mycobacterium tuberculosis (313 aa), FASTA score: (34.5% identity in 110 aa overlap); and MLCL536_27 hypothetical protein from Mycobacterium leprae (315 aa), FASTA score: (34.5% identity in 84 aa overlap). TBparse score is 0.909.; hypothetical protein	831776..832303	Mycobacterium tuberculosis H37Rv	888638
NP_215255.1	CDS	Rv0741	NC_000962.2	832534	832848	D	Rv0741, (MTV041.15), len: 104 aa. Probable truncated transposase for IS1557, showing similarity to transposases and IS elements e.g. U63997|EFU63997_1 insertion sequence from Enterococcus faecium (424 aa), FASTA score: (31.0% identity in 87 aa overlap). Very high similarity with the C-terminal part of Z73419|MTCY373_3 2 IS1557 from Mycobacterium tuberculosis (444 aa), FASTA score: (86.5% identity in 104 aa overlap).; transposase	832534..832848	Mycobacterium tuberculosis H37Rv	888644
YP_177749.1	CDS	PE_PGRS8	NC_000962.2	832981	833508	D	Rv0742, (MTV041.16), len: 175 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to many Mycobacterium tuberculosis PGRS-type proteins e.g. Z78020|MTCY1A11_25 (498 aa), FASTA scores: opt: 766, E(): 6.1e-25, (73.6% identity in 178 aa overlap). Similarity suggests ORF starts with ATA start codon. TBparse score is 0.846.; PE-PGRS family protein	832981..833508	Mycobacterium tuberculosis H37Rv	888645
NP_215257.1	CDS	Rv0743c	NC_000962.2	833886	834443	R	Rv0743c, (MTV041.17c), len: 185 aa. Hypothetical unknown protein. TBparse score is 0.918.; hypothetical protein	complement(833886..834443)	Mycobacterium tuberculosis H37Rv	888641
NP_215258.1	CDS	Rv0744c	NC_000962.2	834440	834946	R	Rv0744c, (MTV041.18c), len: 168 aa. Possible transcriptional regulator, showing weak similarity with O86661|SC4A2.05 PUTATIVE TWO-COMPONENT SENSOR from Streptomyces coelicolor (436 aa), FASTA scores: opt: 117, E(): 0.88, (37.25% identity in 94 aa overlap); and some putative excisionases or transposases. Also weakly similar to P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (114 aa); and Q11144|Y477_MYCTU|Rv0477|MT0495|MTCY20G9.03 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (148 aa). Equivalent to AAK45006 from Mycobacterium tuberculosis strain CDC1551 (179 aa) but shorter 11 aa. Contains probable helix-turn helix motif from aa 5-26 (Score 1350, +3.78 SD). TBparse score is 0.925.; transcriptional regulatory protein	complement(834440..834946)	Mycobacterium tuberculosis H37Rv	888648
NP_215259.1	CDS	Rv0745	NC_000962.2	835154	835681	D	Rv0745, (MTV041.19), len: 175 aa. Conserved hypothetical protein; shows high similarity to a 50 aa region of Rv3649|Z95436|MTY15C10_3 CONSERVED HYPOTHETICAL PROTEIN, similar to ATP-dependent helicases, from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 225, E(): 7e-06, (70.0% identity in 50 aa overlap).; hypothetical protein	835154..835681	Mycobacterium tuberculosis H37Rv	888595
YP_177750.1	CDS	PE_PGRS9	NC_000962.2	835701	838052	D	Rv0746, (MTV041.20), len: 783 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. tuberculosis (914 aa), FASTA scores: opt: 2429, E(): 0, (56.9% identity in 873 aa overlap). Also similar to other PE-PGRS FAMILY PROTEINS e.g. AL0212|MTV008_46 FASTA score: (48.8% identity in 887 aa overlap); etc. TBparse score is 0.860.; PE-PGRS family protein	835701..838052	Mycobacterium tuberculosis H37Rv	888664
YP_177751.1	CDS	PE_PGRS10	NC_000962.2	838451	840856	D	Rv0747, (MTV041.21), len: 801 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. tuberculosis (914 aa), FASTA scores: opt: 2772, E(): 0, (60.9% identity in 941 aa overlap). Also similar to other PE-PGRS FAMILY PROTEINS e.g. Z95844|MTCY493_2 FASTA score: (50.2% identity in 815 aa overlap). Contains PS00012 Phosphopantetheine attachment site.; PE-PGRS family protein	838451..840856	Mycobacterium tuberculosis H37Rv	888662
NP_215262.1	CDS	Rv0748	NC_000962.2	840947	841204	D	Rv0748, (MTV041.22), len: 85 aa. Conserved hypothetical protein, N-terminus similar to N-terminal region of NP_436939.1|NC_003078 HYPOTHETICAL PROTEIN from Sinorhizobium meliloti (75 aa). Also similar to Mycobacterium tuberculosis proteins Rv2871 CONSERVED HYPOTHETICAL PROTEIN (75 aa); Rv1241, Rv2132, Rv3321c, etc. TBparse score is 0.875.; hypothetical protein	840947..841204	Mycobacterium tuberculosis H37Rv	888682
NP_215263.1	CDS	Rv0749	NC_000962.2	841228	841656	D	Rv0749, (MTV041.23), len: 142 aa. Conserved hypothetical protein, similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0749, Rv0277c, Rv2530c, etc.; hypothetical protein	841228..841656	Mycobacterium tuberculosis H37Rv	888681
YP_177632.1	CDS	Rv0749A	NC_000962.2	841737	841874	R	Rv0749A, len: 45 aa. Conserved hypothetical protein (probably gene fragment), similar to part (aa 250-292) of Rv2807|Z81331_12 from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 238, E(): 1.9e-13, (79.07% identity in 43 aa overlap).; hypothetical protein	complement(841737..841874)	Mycobacterium tuberculosis H37Rv	3205052
NP_215264.1	CDS	Rv0750	NC_000962.2	842033	842278	D	Rv0750, (MTV041.24), len: 81 aa. Conserved hypothetical protein, showing almost perfect overlap with C-terminus of Rv0740|MTV041_14 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (175 aa), FASTA scores: (93.8% identity in 81 aa overlap). Possible duplication. TBparse score is 0.872.; hypothetical protein	842033..842278	Mycobacterium tuberculosis H37Rv	888688
NP_215265.1	CDS	mmsB	NC_000962.2	842347	843231	R	Rv0751c, (MTV041.25c), len: 294 aa. Probable mmsB, 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31), highly similar to others e.g. NP_102847.1|NC_002678 3-hydroxyisobutyrate dehydrogenase from Mesorhizobium loti (294 aa); NP_420167.1|NC_002696 3-hydroxyisobutyrate dehydrogenase from Caulobacter crescentus (298 aa); A32867 3-hydroxyisobutyrate dehydrogenase from Rattus norvegicus (346 aa); etc. Also similar to methylmalonate semialdehyde dehydrogenases e.g. M84911|PSE MMSRAB_3 methylmalonate semialdehyde dehydrogenase from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 786, E(): 0, (45.8% identity in 297 aa overlap). Also similar to 6-phosphogluconate dehydrogenases from Mycobacterium tuberculosis e.g. Rv1122 and Rv1844c. Contains PS00895 3-hydroxyisobutyrate dehydrogenase signature. BELONGS TO THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY.; 3-hydroxyisobutyrate dehydrogenase MmsB	complement(842347..843231)	Mycobacterium tuberculosis H37Rv	888658
NP_215266.1	CDS	fadE9	NC_000962.2	843242	844414	R	Rv0752c, (MTV041.26c), len: 390 aa. Probable fadE9, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. NP_437985.1|NC_003078 putative acyl-CoA dehydrogenase protein from Sinorhizobium meliloti (380 aa); Z99123|BSUB0020_14 from Bacillus subtilis (379 aa), FASTA scores: opt: 853, E(): 0, (39.8% identity in 384 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, and PS00073 Acyl-Co Adehydrogenases signature 2. BELONGS TO THE ACYL-CoA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE9	complement(843242..844414)	Mycobacterium tuberculosis H37Rv	888684
NP_215267.1	CDS	mmsA	NC_000962.2	844421	845953	R	Rv0753c, (MTV041.27c), len: 510 aa. Probable mmsA, methylmalonic acid semialdehyde dehydrogenase (EC 1.2.1.27), highly similar to others e.g. NP_420115.1|NC_002696 putative methylmalonate-semialdehyde dehydrogenase from Caulobacter crescentus (499 aa); L48550|STMMSDA_1|CAB75315.1|AL139164 methylmalonic acid semialdehyde dehydrogenase from Streptomyces coelicolor (500 aa), FASTA score: (51.6% identity in 498 aa overlap); M84911|PSEMMSRAB_2|NP_252260.1|NC_002516 methylmalonate-semialdehyde dehydrogenase from Pseudomonas aeruginosa (497 aa), FASTA scores: opt: 1127, E(): 0, (47.9% identity in 507 aa overlap); etc. Note that also highly similar to malonic semialdehyde oxidative decarboxylases e.g. NP_104968.1|NC_002678 malonic semialdehyde oxidative decarboxylase from Mesorhizobium loti (498 aa); NP_384832.1|NC_003047 PUTATIVE MALONIC SEMIALDEHYDE OXIDATIVE DECARBOXYLASE PROTEIN from Sinorhizobium meliloti (498 aa); etc. Contains PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.; methylmalonate-semialdehyde dehydrogenase	complement(844421..845953)	Mycobacterium tuberculosis H37Rv	888707
YP_177752.1	CDS	PE_PGRS11	NC_000962.2	846159	847913	D	Rv0754, (MTV041.28), len: 584 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to others e.g. AL0212|MTV008_46 from Mycobacterium tuberculosis (1660 aa), FASTA score: (48.7% identity in 345 aa overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa), FASTA score: (41.6% identity in 442 aa overlap); etc.; PE-PGRS family protein	846159..847913	Mycobacterium tuberculosis H37Rv	888695
YP_177753.1	CDS	PPE12	NC_000962.2	848103	850040	R	Rv0755c, (MTV041.29), len: 645 aa. Member of the Mycobacterium tuberculosis PPE family, highly similar to others e.g. Z82098|MTCY3C7_23 from Mycobacterium tuberculosis (582 aa), FASTA scores: (56.1% identity in 636 aa overlap); Z92774|MTCY6G11_5 from Mycobacterium tuberculosis (552 aa), FASTA scores: (55.8% identity in 590 aa overlap); etc.; PPE family protein	complement(848103..850040)	Mycobacterium tuberculosis H37Rv	888708
YP_177633.1	CDS	Rv0755A	NC_000962.2	850342	850527	R	Rv0755A, len: 61 aa. Putative transposase (possibly gene fragment), similar to C-terminal part of Q9EZM2|ISMav2|AF286339_1 putative transposase from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 284, E(): 5e-13, (83.02% identity in 53 aa overlap); and to SCJ11.25c|Q9RI80 possible noncomposite transposon transposase from Streptomyces coelicolor (283 aa).; transposase	complement(850342..850527)	Mycobacterium tuberculosis H37Rv	3205072
NP_215270.1	CDS	Rv0756c	NC_000962.2	850741	851466	R	Rv0756c, (MTCY369.01c), len: 241 aa. Hypothetical unknown protein.; hypothetical protein	complement(850741..851466)	Mycobacterium tuberculosis H37Rv	888730
NP_215271.1	CDS	phoP	NC_000962.2	851608	852351	D	Rv0757, (MTCY369.02), len: 247 aa. Possible phoP, two component system response phosphate regulon transcriptional regulator (see citations below), highly similar to various transcriptional regulators e.g. CAC32360.1|AL583945 putative two component system response regulator from Streptomyces coelicolor (271 aa); T45446 probable two-component response regulator from Mycobacterium leprae (253 aa); and similar to phoP proteins e.g. P13792|PHOP_BACSU alkaline phosphatase synthesis transcription regulatory protein from Bacillus subtilis (240 aa), FASTA scores: opt: 594, E(): 2.3e-33, (41.0% identity in 234 aa overlap); etc. Also highly similar to Rv3765c from Mycobacterium tuberculosis (234 aa), Rv1033c (257 aa), RV0903c|MTCY31.31c|Q10531 (236 aa), FASTA score: (45.4% identity in 229 aa overlap); MTCY10G2_16 and MTU88959_1.; two component system response transcriptional positive regulator PHOP	851608..852351	Mycobacterium tuberculosis H37Rv	888772
NP_215272.1	CDS	phoR	NC_000962.2	852396	853853	D	Rv0758, (MTCY369.03), len: 485 aa. Possible phoR, two component system response phosphate sensor kinase membrane-associated (EC 2.7.-.-), highly similar to various sensor kinases e.g. CAC32361.1|AL583945 putative two component system histidine kinase from Streptomyces coelicolor (524 aa); NP_349365.1|NC_003030 Membrane-associated sensory histidine kinase with HAMP domain from Clostridium acetobutylicum (482 aa); and similar to phoP proteins e.g. NP_372216.1|NC_002758 alkaline phosphatase synthesis sensor protein from Staphylococcus aureus (554 aa); P23545|PHOR_BACSU alkaline phosphatase synthesis sensor from Bacillus subtilis (579 aa), FASTA scores: opt: 515, E(): 1.9e-25, (40.0% identity in 230 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. MTCY20G9.16 FASTA scores: (34.5% identity in 264 aa overlap), MTU88959_2 (509 aa), MTCY10G2_17, etc.; two component system response sensor kinase membrane associated PHOR	852396..853853	Mycobacterium tuberculosis H37Rv	888775
NP_215273.1	CDS	Rv0759c	NC_000962.2	853825	854157	R	Rv0759c, (MTCY369.04c), len: 110 aa. Conserved hypothetical protein, highly similar (but shorter 45 aa in N-terminus) to P49774|YHIT_MYCLE|ML2237|MLCB5.04c|U296A HYPOTHETICAL HIT-LIKE PROTEIN from Mycobacterium leprae (155 aa), FASTA scores: opt: 766, E(): 0, (78.7% identity in 150 aa overlap). Also highly similar (but N-terminus always shorter) to HIT-like proteins and protein kinase inhibitors e.g. AAF72728.1|AF265258_1|AF265258 HIT-like protein from Rhodococcus sp. (141 aa); NP_212513.1|NC_001318 protein kinase C1 inhibitor (pkcI) from Borrelia burgdorferi (149 aa) ; P94252|YHIT_BORBU|BB0379 HYPOTHETICAL HIT-LIKE PROTEIN from Borrelia burgdorferi (139 aa); NP_110768.1|NC_002689 HIT (histidine triad) family protein from Thermoplasma volcanium (158 aa); P16436|IPK1_BOVIN protein kinase C inhibitor 1 (pkci-1) from Bos taurus (Bovine) (125 aa), FASTA scores: opt: 195, E(): 5.2e-08, (33.3% identity in 111 aa overlap); etc. Also shows similarity with Rv2613c|MTCY01A10.20A CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (195 aa) and Rv1262c|MTCY50.20 HYPOTHETICAL HIT-LIKE PROTEIN (144 aa).; hypothetical protein	complement(853825..854157)	Mycobacterium tuberculosis H37Rv	888776
NP_215274.1	CDS	Rv0760c	NC_000962.2	854267	854686	R	Rv0760c, (MTCY369.05), len: 139 aa. Conserved hypothetical protein, similar to N-terminal part of Rv2042c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (265 aa), FASTA scores: opt: 150, E(): 4.1e-05, (28.7% identity in 136 aa overlap).; hypothetical protein	complement(854267..854686)	Mycobacterium tuberculosis H37Rv	888784
YP_177754.1	CDS	adhB	NC_000962.2	854699	855826	R	Rv0761c, (MTCY369.06c), len: 375 aa. Possible adhB, zinc-containing alcohol dehydrogenase NAD-dependent (EC 1.1.1.1), similar to others e.g. AAC15839.1|AF060871_4 hypothetical alcohol dehydrogenase from Rhodococcus rhodochrous (370 aa), FASTA scores: opt: 1234, E(): 0, (46.8% identity in 370 aa overlap); P80468|ADH2_STRCA ALCOHOL DEHYDROGENASE II from Struthio camelus (Ostrich) (379 aa); Q03505|ADH1_RABIT alcohol dehydrogenase alpha chain from Oryctolagus cuniculus (Rabbit) (374 aa), FASTA scores: opt: 872, E(): 0, (39.1% identity in 379 aa overlap); etc. Also similar to adhD alcohol dehydrogenase from Mycobacterium tuberculosis (368 aa). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY.; zinc-containing alcohol dehydrogenase NAD dependent ADHB	complement(854699..855826)	Mycobacterium tuberculosis H37Rv	888738
NP_215276.1	CDS	Rv0762c	NC_000962.2	855925	856470	R	Rv0762c, (MTCY369.07c), len: 181 aa. Conserved hypothetical protein, showing weak similarity to D90907_77|P73575 HYPOTHETICAL 31.3KD PROTEIN from Synechocystis sp, FASTA scores: E(): 0.0012, (30.4% identity in 92 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	complement(855925..856470)	Mycobacterium tuberculosis H37Rv	888807
NP_215277.1	CDS	Rv0763c	NC_000962.2	856473	856679	R	Rv0763c, (MTCY369.08c), len: 68 aa. Possible ferredoxin, similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa); AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa); etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c PROBABLE CYTOCHROME P450 51 from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: 137, E(): 0.00013, (36.4% identity in 66 aa overlap). Also similar to putative ferredoxins Rv3503c and Rv1786 from Mycobacterium tuberculosis. COULD BELONG TO THE BACTERIAL TYPE FERREDOXIN FAMILY.; ferredoxin	complement(856473..856679)	Mycobacterium tuberculosis H37Rv	888814
NP_215278.1	CDS	cyp51	NC_000962.2	856682	858037	R	Rv0764c, (MT0788, MTCY369.09c), len: 451 aa. cyp51, cytochrome P450 51 (sterol 14-alpha demethylase) (EC 1.14.14.-), similar to others e.g. Q16850|CP51_HUMAN CYTOCHROME P450 51 (CYPL1) (P450L1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Homo sapiens (509 aa), FASTA scores: opt: 848, E(): 0, (33.9% identity in 439 aa overlap); NP_172633.1|NC_003070 putative obtusifoliol 14-alpha demethylase from Arabidopsis thaliana (488 aa); P93596|CP51_WHEAT CYTOCHROME P450 51 (CYPL1) (P450-L1A1) (OBTUSIFOLIOL 14-ALPHA DEMETHYLASE) from Triticum aestivum (453 aa); etc. Also similar to many other Mycobacterium tuberculosis cytochromes P450 e.g. Rv1394c, FASTA score: (22.5% identity in 444 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.; cytochrome P450 sterol 14-alpha demethylase	complement(856682..858037)	Mycobacterium tuberculosis H37Rv	888819
NP_215279.1	CDS	Rv0765c	NC_000962.2	858037	858864	R	Rv0765c, (MTCY369.10c), len: 275 aa. Probable oxidoreductase (EC 1.-.-.-), similar others e.g. P39071|DHBA_BACSU 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from Bacillus subtilis (261 aa), FASTA scores: opt: 385, E(): 1.8e-17, (30.6% identity in 252 aa overlap); AAF81239.1|AF263012 putative beta-ketoacyl reductase from Streptomyces griseus (274 aa); NP_436514.1|NC_003037 putative oxidoreductase from Sinorhizobium meliloti (240 aa); etc. Also similar to several other oxidoreductases from Mycobacterium tuberculosis e.g. Rv1544|MTCY48.21, FASTA score: (32.6% identity in 267 aa overlap); etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature.; short chain dehydrogenase	complement(858037..858864)	Mycobacterium tuberculosis H37Rv	888793
NP_215280.1	CDS	cyp123	NC_000962.2	858864	860072	R	Rv0766c, (MT0790, MTCY369.11c), len: 402 aa. Probable cyp123, cytochrome P-450 (EC 1.14.-.-), similar to others e.g. P33271|CPXK_SACER cytochrome P-450 107B1 from Saccharopolyspora erythraea (405 aa), FASTA scores: opt: 770, E(): 0, (36.9% identity in 406 aa overlap); T36526 probable cytochrome P450 hydroxylase from Streptomyces coelicolor (411 aa); P27632|CPXM_BACSU CYTOCHROME P450 109 from Bacillus subtilis (405 aa); etc. Also similar to several other cytochromes P-450 from Mycobacterium tuberculosis e.g. Rv1256c|MTCY50.26 (405 aa), FASTA score: (35.2% identity in 389 aa overlap); etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.; cytochrome P450 123	complement(858864..860072)	Mycobacterium tuberculosis H37Rv	888834
NP_215281.1	CDS	Rv0767c	NC_000962.2	860069	860710	R	Rv0767c, (MTCY369.12c), len: 213 aa. Conserved hypothetical protein, showing weak similarity with AL133220|SCC75A_26 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (215 aa), FASTA scores: opt: 152, E(): 0.0048, (28.4% identity in 204 aa overlap).; hypothetical protein	complement(860069..860710)	Mycobacterium tuberculosis H37Rv	888833
NP_215282.1	CDS	aldA	NC_000962.2	860912	862381	D	Rv0768, (MTCY369.13), len: 489 aa. Probable aldA, NAD-dependent aldehyde dehydrogenase (EC 1.2.1.-), highly similar to others e.g. AAL14238.1|AY052630 6-oxolauric acid dehydrogenase from Rhodococcus ruber (474 aa); NP_285450.1|NC_001264 aldehyde dehydrogenase from Deinococcus radiodurans (495 aa); NP_241405.1|NC_002570 NADP-dependent aldehyde dehydrogenase from Bacillus halodurans (498 aa); P42757|DHAB_ATRHO betaine-aldehyde dehydrogenase precursor from Atriplex hortensis (Mountain spinach) (502 aa), FASTA scores: opt: 1001, E(): 0, (35.6% identity in 486 aa overlap); etc. Also highly similar to Rv0223c ALDEHYDE DEHYDROGENASE from Mycobacterium tuberculosis (487 aa). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.; aldehyde dehydrogenase NAD dependent AldA	860912..862381	Mycobacterium tuberculosis H37Rv	888832
NP_215283.1	CDS	Rv0769	NC_000962.2	862412	863158	D	Rv0769, (MTCY369.14), len: 248 aa. Probable dehydrogenase/reductase (EC 1.-.-.-), similar to others, especially short-chain type dehydrogenases/reductases and 3-oxoacyl-(acyl-carrier protein) reductases e.g. NP_106890.1|NC_002678 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from Mesorhizobium loti (374 aa); NP_243357.1|NC_002570 3-oxoacyl-(acyl-carrier protein) reductase from Bacillus halodurans (246 aa); P28643|FABG_CUPLA 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE from Cuphea lanceolata (320 aa); P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 536, E(): 6.5e-27, (37.7% identity in 247 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. MTCY02B10.14, FASTA score: (33.7% identity in 249 aa overlap); etc.; short chain dehydrogenase	862412..863158	Mycobacterium tuberculosis H37Rv	888837
NP_215284.1	CDS	Rv0770	NC_000962.2	863256	864143	D	Rv0770, (MTCY369.15), len: 295 aa. Probable dehydrogenase/reductase, 3-hydroxyisobutyrate dehydrogenase family (EC 1.1.1.-), possibly 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) or 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60), similar to others e.g. P23523|GARR_ECOLI 2-HYDROXY-3-OXOPROPIONATE REDUCTASE (TARTRONATE SEMIALDEHYDE REDUCTASE) (TSAR) from Escherichia coli strain K12 (294 aa), FASTA scores: opt: 469, E(): 6.7e-22, (34.4% identity in 282 aa overlap); P28811|MMSB_PSEAE 3-hydroxyisobutyrate dehydrogenase (HIBADH) from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 439, E(): 4.3e-20, (34.9% identity in 269 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv1122 and Rv1844c. SEEMS TO BELONG TO THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY.; dehydrogenase/reductase	863256..864143	Mycobacterium tuberculosis H37Rv	888868
NP_215285.1	CDS	Rv0771	NC_000962.2	864140	864574	D	Rv0771, (MTCY369.16), len: 144 aa. Possible 4-carboxymuconolactone decarboxylase (EC 4.1.1.44), showing similarity with other carboxymuconolactone decarboxylases e.g. AAD39557.1|AF031417 PcaC-like protein from Pseudomonas putida (130 aa); P20370|DC4C_ACICA 4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD) from Acinetobacter sp. ADP1 (134 aa), FASTA scores: opt: 174, E(): 0.00075, (31.4% identity in 121 aa overlap); C-terminus of NP_421214.1|NC_002696 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Caulobacter crescentus (393 aa); C-terminus of T47115 probable 4-carboxymuconolactone decarboxylase / 3-oxoadipate enol-lactone hydrolase from Streptomyces sp (373 aa); NP_407104.1|NC_003143 putative gamma carboxymuconolactone decarboxylase from Yersinia pestis (131 aa); etc.; 4-carboxymuconolactone decarboxylase	864140..864574	Mycobacterium tuberculosis H37Rv	888872
NP_215286.1	CDS	purD	NC_000962.2	864586	865854	D	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase	864586..865854	Mycobacterium tuberculosis H37Rv	888873
NP_215287.1	CDS	ggtA	NC_000962.2	865851	867389	R	Rv0773c, (MTCY369.18), len: 512 aa. Probable ggtA, bifunctional acylase including cephalosporin acylase (EC 3.5.1.-), and gamma-glutamyl transpeptidase (EC 2.3.2.2); highly similar to others e.g. NP_295247.1|NC_001263 cephalosporin acylase from Deinococcus radiodurans (535 aa); NP_248854.1|NC_002516 probable gamma-glutamyltranspeptidase from Pseudomonas aeruginosa (538 aa); P15557|PAC1_PSES3 ACYLASE ACY 1 [INCLUDES: CEPHALOSPORIN ACYLASE (GL-7ACA ACYLASE); GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT)] from Pseudomonas sp. strain SE83 (558 aa), FASTA scores: opt: 784, E(): 0, (34.2% identity in 526 aa overlap); NP_391491.1|NC_000964|Z93767|BSZ93767_6|O0521 protein similar to gamma-glutamyltransferase from Bacillus subtilis (525 aa), FASTA scores: opt: 1169, E(): 0, (40.1% identity in 516 aa overlap); etc. Also similar to Rv2394|ggtB from Mycobacterium tuberculosis. Member of GL-7ACA ACYLASES AND TO GGT group.; bifunctional cephalosporin acylase/gamma-glutamyltranspeptidase	complement(865851..867389)	Mycobacterium tuberculosis H37Rv	888893
NP_215288.2	CDS	Rv0774c	NC_000962.2	867440	868351	R	Rv0774c, (MTCY369.19c), len: 303 aa. Possible conserved exported protein with hydrophobic region near N-terminus, highly similar, except in N-terminus, to Rv0519c|Z97831|MTY20G10.09c|O33364 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (300 aa), FASTA scores: opt: 1092, E(): 0, (57.9% identity in 299 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature, and PS00120 Lipases, serine active site. So could be a lipase (EC 3.1.-.-). Start changed since first submission (-9 aa).; hypothetical protein	complement(867440..868351)	Mycobacterium tuberculosis H37Rv	888895
NP_215289.1	CDS	Rv0775	NC_000962.2	868407	869030	D	Rv0775, (MTCY369.20), len: 207 aa. Conserved hypothetical protein, showing some similarity to other proteins e.g. ECAE000186_11|MG1655 HYPOTHETICAL PROTEIN from Escherichia coli strain K-12 (178 aa), FASTA scores: E(): 6.4e-05, (27.2% identity in 147 aa overlap); P41037|BIH_ECOLI hypothetical transcriptional regulator from Escherichia coli (103 aa), FASTA scores: opt: 138, E(): 0.003, (30.9% identity in 97 aa overlap); etc.; hypothetical protein	868407..869030	Mycobacterium tuberculosis H37Rv	888899
NP_215290.1	CDS	Rv0776c	NC_000962.2	868984	869763	R	Rv0776c, (MTCY369.21a), len: 259 aa. Conserved hypothetical protein, similar (except first 50 aa) to P72737|D90900_57 hypothetical protein from Synechocystis sp. strain PCC 6803 (261 aa), FASTA scores: opt: 337, E(): 1.7e-15, (30.5% identity in 266 aa overlap).; hypothetical protein	complement(868984..869763)	Mycobacterium tuberculosis H37Rv	888918
NP_215291.1	CDS	purB	NC_000962.2	870008	871426	D	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase	870008..871426	Mycobacterium tuberculosis H37Rv	888929
NP_215292.1	CDS	cyp126	NC_000962.2	871431	872675	D	Rv0778, (MT0802, MTCY369.22), len: 414 aa. Possible cyp126, cytochrome P-450 (EC 1.14.-.-), similar to other cytochromes and related proteins e.g. AAG29781.1|AF235050_4|AF235050 cytochrome P-450 from Streptomyces rishiriensis (407 aa); Q59723|PSECYTOCHR_1 cytochrome p-450 linalool 8-monooxygenase (EC 1.14.99.28) (lin C) from Pseudomonas incognita (406 aa), FASTA scores: opt: 769, E(): 0, (37.0% identity in 411 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0766c, Rv2266, Rv3545c, etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature.; cytochrome P450 126	871431..872675	Mycobacterium tuberculosis H37Rv	888913
NP_215293.1	CDS	Rv0779c	NC_000962.2	872672	873292	R	Rv0779c, (MTCY369.23c), len: 206 aa. Possible conserved transmembrane protein, equivalent to Z95151|MLCB5_14 O05747 conserved hypothetical protein from Mycobacterium leprae (206 aa), FASTA scores: opt: 902, E(): 0, (67.2% identity in 204 aa overlap).; transmembrane protein	complement(872672..873292)	Mycobacterium tuberculosis H37Rv	888941
NP_215294.1	CDS	hemH	NC_000962.2	873343	874236	D	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase	873343..874236	Mycobacterium tuberculosis H37Rv	888928
NP_215296.2	CDS	ptrBa	NC_000962.2	874233	874943	D	Rv0781, (MTCY369.25), len: 236 aa. Probable ptrBa, first part of protease II (EC 3.4.21.83), equivalent to N-terminus of NP_302455.1|NC_002677 protease II from Mycobacterium leprae (724 aa). Also highly similar to N-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa), FASTA scores: opt: 204, E(): 7.4e-07, (29.6% identity in 230 aa overlap); etc. ORFs Rv0782 and Rv0781 appear to be a frameshifted homologues of protease II, but we can find no error in the cosmid sequence to account for this. BELONGS TO PEPTIDASE FAMILY S9A; ALSO KNOWN AS THE PROLYL OLIGOPEPTIDASE FAMILY. Note that previously known as ptrBb.; ptrBb; oligopeptidase B	874233..874943	Mycobacterium tuberculosis H37Rv	885840
NP_215295.2	CDS	ptrBb	NC_000962.2	874732	876390	D	Rv0782, (MTCY369.26), len: 552 aa. Probable ptrBb, second part of protease II (EC 3.4.21.83), equivalent to C-terminus of NP_302455.1|NC_002677 protease II from Mycobacterium leprae (724 aa). Also highly similar to N-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa), FASTA scores: opt: 1251, E(): 0, (42.7% identity in 489 aa overlap); etc. ORFs Rv0782 and Rv0781 appear to be a frameshifted homologues of protease II, but we can find no error in the cosmid sequence to account for this. BELONGS TO PEPTIDASE FAMILY S9A; ALSO KNOWN AS THE PROLYL OLIGOPEPTIDASE FAMILY. Note that previously known as ptrBa.; ptrBa; oligopeptidase B	874732..876390	Mycobacterium tuberculosis H37Rv	885862
NP_215297.1	CDS	emrB	NC_000962.2	876818	878440	R	Rv0783c, (MTCY369.27c), len: 540 aa. Possible emrB, integral membrane drug efflux protein, member of major facilitator superfamily (MFS), equivalent to AAL16083.1|AF421382_1|AF421382 EmrB efflux protein from Mycobacterium avium (538 aa). Also similar to other membrane proteins e.g. CAB61606.1|AL133210 putative export protein from Streptomyces coelicolor (496 aa); NP_108371.1|NC_002678 efflux pump protein FarB from Mesorhizobium loti (511 aa); P44927|EMRB_HAEINHI0897| multidrug resistance protein b homologue from Haemophilus influenzae (510 aa), FASTA scores: opt: 706, E(): 1.3e-36, (30.4% identity in 408 aa overlap); etc. Also similar to Rv2333c|MTCY3G12.01 from Mycobacterium tuberculosis (537 aa), FASTA score: (28.2% identity in 408 aa overlap); and Rv1410c|MTCY21B4.27c from Mycobacterium tuberculosis (518 aa), FASTA score: (26.8% identity in 496 aa overlap). BELONGS TO THE MAJOR FACILITATOR FAMILY; ALSO KNOWN AS THE DRUG RESISTANCE TRANSLOCASE FAMILY.; multidrug resistance integral membrane efflux protein EmrB	complement(876818..878440)	Mycobacterium tuberculosis H37Rv	885836
NP_215298.1	CDS	Rv0784	NC_000962.2	878638	879324	D	Rv0784, (MTC369.28), len: 228 aa. Conserved hypothetical protein, with some similarity to MLCB5_20|O05752 hypothetical protein from Mycobacterium leprae (193 aa), FASTA scores: opt: 141, E(): 0.0022, (36.0% identity in 114 aa overlap). Also similar to N-terminus of NP_253002.1|NC_002516 conserved hypothetical protein from Pseudomonas aeruginosa (253 aa).; hypothetical protein	878638..879324	Mycobacterium tuberculosis H37Rv	885863
NP_215299.1	CDS	Rv0785	NC_000962.2	879340	881040	D	proposed role in polysaccahride synthesis; putative FAD-binding dehydrogenase	879340..881040	Mycobacterium tuberculosis H37Rv	885864
NP_215300.1	CDS	Rv0786c	NC_000962.2	881075	881464	R	Rv0786c, (MTCY369.30c), len: 129 aa. Conserved hypothetical protein, similar to three other hypothetical proteins from Streptomyces coelicolor e.g. SC7H1.08c|T35703 hypothetical protein (202 aa), FASTA scores: opt: 241, E(): 5.1e-10, (41.0% identity in 105 aa overlap); SC3A7.08|T29426 (211 aa).; hypothetical protein	complement(881075..881464)	Mycobacterium tuberculosis H37Rv	885615
NP_215301.1	CDS	Rv0787	NC_000962.2	881459	882418	D	Rv0787, (MTCY369.31), len: 319 aa. Hypothetical unknown protein, equivalent to AAK45053.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 77 aa.; hypothetical protein	881459..882418	Mycobacterium tuberculosis H37Rv	885468
YP_177755.1	CDS	Rv0787A	NC_000962.2	882524	882763	D	With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS	882524..882763	Mycobacterium tuberculosis H37Rv	886264
NP_215303.1	CDS	purQ	NC_000962.2	882760	883434	D	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I	882760..883434	Mycobacterium tuberculosis H37Rv	885181
NP_215304.1	CDS	Rv0789c	NC_000962.2	883451	884050	R	Rv0789c, (MTCY369.33c), len: 199 aa. Hypothetical unknown protein.; hypothetical protein	complement(883451..884050)	Mycobacterium tuberculosis H37Rv	885153
NP_215305.1	CDS	Rv0790c	NC_000962.2	884072	884800	R	Rv0790c, (MTCY369.34c), len: 242 aa. Hypothetical unknown protein.; hypothetical protein	complement(884072..884800)	Mycobacterium tuberculosis H37Rv	885253
NP_215306.1	CDS	Rv0791c	NC_000962.2	884797	885840	R	Rv0791c, (MTV042.01c, MTCY369.35c), len: 347 aa. Conserved hypothetical protein, similar (except in N-terminus) to others e.g. CAC44585.1|AL596162 conserved hypothetical protein from Streptomyces coelicolor (307 aa); NP_252643.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (364 aa); etc. Also some similarity with oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); etc. And also similar in part to other proteins from Mycobacterium tuberculosis e.g. Rv1855c|MTCY359.18|Z83859 (307 aa), FASTA scores: opt: 366, E(): 4e-16, (35.0% identity in 226 aa overlap); Rv3079c|MTCY22D7.02|Z83866 CONSERVED HYPOTHETICAL PROTEIN (275 aa), FASTA scores: opt: 342, E(): 1.2e-14, (31.6% identity in 234 aa overlap); Rv0044c POSSIBLE OXIDOREDUCTASE (264 aa). TBparse score is 0.916.; hypothetical protein	complement(884797..885840)	Mycobacterium tuberculosis H37Rv	885273
NP_215307.1	CDS	Rv0792c	NC_000962.2	885837	886646	R	Rv0792c, (MTV042.02c), len: 269 aa. Probable transcriptional regulator, GntR-family, similar to many others of GntR family e.g. BSUB0018_189|Z99121 from Bacillus subtilis (243 aa), FASTA scores: opt: 367, E(): 1.5e-17, (32.1% identity in 246 aa overlap); P31453|YIDP_ECOLI from Escherichia coli (238 aa), FASTA scores: opt: 236, E(): 8.8e-09, (26.4% identity in 235 aa overlap); etc. TBparse score is 0.932.; GntR family transcriptional regulator	complement(885837..886646)	Mycobacterium tuberculosis H37Rv	885142
NP_215308.1	CDS	Rv0793	NC_000962.2	886719	887024	D	Rv0793, (MTV042.03), len: 101 aa. Conserved hypothetical protein, similar to others e.g. NP_250888.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (114 aa); AE 001908|AE001908_7 hypothetical protein from Deinococcus radiodurans (101 aa), FASTA scores: opt: 215, E(): 3.1e-09, (40.4% identity in 99 aa overlap); NP_440966.1|NC_000911|D90908|PCC6803|D90908_2 unknown protein from Synechocystis sp. strain PCC 6803 (147 aa), FASTA scores: opt: 194, E(): 4.5e-08, (31.1% identity in 90 aa overlap); etc. Also similar to Rv2749|MTV002.14|AL0089|MTV002_15 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (104 aa), FASTA scores: opt: 143, E(): 0.00026, (26.9% identity in 93 aa overlap). TBparse score is 0.912.; hypothetical protein	886719..887024	Mycobacterium tuberculosis H37Rv	885497
YP_177756.1	CDS	Rv0794c	NC_000962.2	887137	888636	R	Rv0794c, (MTV042.04c), len: 499 aa. Probable oxidoreductase (EC 1.-.-.-), possibly dihydrolipoamide dehydrogenase (EC 1.8.1.4) or mercuric reductase (EC 1.16.1.1). Highly similar to CAB62675.1|AL133422 probable oxidoreductase from Streptomyces coelicolor (477 aa); and similar to various oxidoreductases e.g. P08663|MERA_STAAU MERCURIC REDUCTASE (HG(II) REDUCTASE) (EC 1.16.1.1) from Staphylococcus aureus (547 aa); AAK70920.1|AC087551_19|AC087551 putative lipoamide dehydrogenase from Oryza sativa (563 aa); NP_437349.1|NC_003078 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase, similar to mercuric reductases protein from Sinorhizobium meliloti (473 aa); Q04829|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Haloferax volcanii (475 aa); P08332|MERA_SHIFL MERCURIC REDUCTASE (EC 1.16.1.1) (564 aa), FASTA scores: opt: 522, E(): 3.7e-26, (31.7% identity in 467 aa overlap); P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096 DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from Synechocystis sp. strain PCC 6803 (474 aa), FASTA scores: opt: 602, E(): 2.3e-31, (31.0% identity in 493 aa overlap); etc. TBparse score is 0.909. Note that previously known as lpdB.; lpdB; oxidoreductase	complement(887137..888636)	Mycobacterium tuberculosis H37Rv	885076
NP_215310.1	CDS	Rv0795	NC_000962.2	889072	889398	D	Rv0795, (MTV042.05), len: 108 aa. Putative transposase for IS6110 (fragment), identical to Q50686 INSERTION ELEMENT IS6110 (108 aa), FASTA score: (100.0 % identity in 108 aa overlap). TBparse score is 0.928.; transposase IS6110	889072..889398	Mycobacterium tuberculosis H37Rv	885454
NP_215311.1	CDS	Rv0796	NC_000962.2	<889395	890333	D	Rv0796, (MTV042.06), len: 312 aa. Putative transposase for IS6110. TBparse score is 0.926.; transposase IS6110	<889395..890333	Mycobacterium tuberculosis H37Rv	885099
NP_215312.1	CDS	Rv0797	NC_000962.2	890388	891482	D	Rv0797, (MTCI249B.03c, MTV042.07), len 364 aa. Putative transposase for IS1547; almost identical to (but 20 aa shorter than) Y13470|MTY13470_2 from Mycobacterium tuberculosis (383 aa). Also similar to other transposases e.g. MAIS1110A _1|Q48909 transposase from Mycobacterium avium (464 aa), FASTA scores: opt: 226, E(): 2.4e-08, (30.7% identity in 199 aa overlap). Also slight similarity to Rv2014|MTCY39.03c from Mycobacterium tuberculosis (222 aa), FASTA score: (24.8% identity in 141 aa overlap).; IS1547 transposase	890388..891482	Mycobacterium tuberculosis H37Rv	885476
NP_215313.1	CDS	cfp29	NC_000962.2	891472	892269	R	Rv0798c, (MTCI429B.02), len: 265 aa. cfp29, 29 kDa antigen (see citations below). Highly similar to Q45296|BLLINM18P_1|CAA63787.1|X93588 linocin M18 from Brevibacterium linens (266 aa), FASTA scores: (58.5% identity in 265 aa overlap). Also shows similarity with NP_228594.1|NC_000853 bacteriocin from Thermotoga maritima (262 aa).; 29 kDa antigen CFP29	complement(891472..892269)	Mycobacterium tuberculosis H37Rv	885460
NP_215314.1	CDS	Rv0799c	NC_000962.2	892266	893273	R	Rv0799c, (MTCY07H7A.10, MTCI429B.01), len: 335 aa. Conserved hypothetical protein, similar to Q50021|U2266C from Mycobacterium leprae (146 aa), FASTA scores: opt: 147, E(): 0.0016, (33.3% identity in 117 aa overlap); Q50020|U2266B from Mycobacterium leprae (27 aa), FASTA scores: opt: 94, E(): 1.3, (56.5% identity in 23 aa overlap). Also highly similar to others e.g. CAC01593.1|AL391041 conserved hypothetical protein from Streptomyces coelicolor (316 aa); AF088897|AF088897_9 hypothetical protein from Zymomonas mobilis (322 aa), FASTA scores: opt: 1132, E(): 0, (56.1% identity in 303 aa overlap); P76536|ECAE000330_8 hypothetical protein from Escherichia coli strain K-12 (308 aa), FASTA scores: E(): 2.2e-30, (37.4% identity in 297 aa overlap); etc. Also similar to some tyrA proteins.; hypothetical protein	complement(892266..893273)	Mycobacterium tuberculosis H37Rv	885388
NP_215315.1	CDS	pepC	NC_000962.2	893318	894619	D	catalyzes the removal of amino acids from the N termini of peptides; putative aminopeptidase 2	893318..894619	Mycobacterium tuberculosis H37Rv	885461
NP_215316.1	CDS	Rv0801	NC_000962.2	894631	894978	D	Rv0801, (MTCY07H7A.08c), len: 115 aa. Conserved hypothetical protein, similar to many hypothetical proteins from Streptomyces sp. e.g. SCD840A.20|AB81865.1|AL161691 hypothetical protein from Streptomyces coelicolor (145 aa); AF072709|AF072709_8 from Streptomyces lividans (131 aa), FASTA scores: opt: 120, E(): 0.2, (26.3% identity in 118 aa overlap); etc.; hypothetical protein	894631..894978	Mycobacterium tuberculosis H37Rv	885376
NP_215317.1	CDS	Rv0802c	NC_000962.2	894972	895628	R	Rv0802c, (MTCY07H7A.07c), len: 218 aa. Conserved hypothetical protein, showing partial similarity with many acetyltransferases and hypothetical proteins e.g. P96579|BSUB0003_68 PROBABLE ACETYLTRANSFERASE from Bacillus subtilis (183 aa), FASTA scores: E(): 0.0044, (26.4% identity in 110 aa overlap).; hypothetical protein	complement(894972..895628)	Mycobacterium tuberculosis H37Rv	885332
NP_215318.1	CDS	purL	NC_000962.2	895820	898084	D	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II	895820..898084	Mycobacterium tuberculosis H37Rv	885358
NP_215319.1	CDS	Rv0804	NC_000962.2	898081	898710	D	Rv0804, (MTCY07H7A.05c), len: 209 aa. Conserved hypothetical protein, showing similarity with C-terminus of Rv1863c|MTCY359.10 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (256 aa), FASTA scores: opt: 199, E(): 1.2e-05, (33.2% identity in 220 aa overlap); and Rv0658c. Contains PS01151 Fimbrial biogenesis outer membrane usher protein signature.; hypothetical protein	898081..898710	Mycobacterium tuberculosis H37Rv	885330
NP_215320.1	CDS	Rv0805	NC_000962.2	898831	899787	D	Rv0805, (MTCY07H7A.04c), len: 318 aa. Conserved hypothetical protein, equivalent to Q50024 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (317 aa), FASTA scores: opt: 1713, E(): 0, (82.5% identity in 315 aa overlap). Also shows similarity with hypothetical proteins and icc proteins e.g. SC9B1.22c|T35867 hypothetical protein from Streptomyces coelicolor (305 aa); P36650|ICC_ECOLI icc protein from Escherichia coli (275 aa), FASTA scores: opt: 310, E(): 8.9e-14, (31.3% identity in 214 aa overlap); etc.; hypothetical protein	898831..899787	Mycobacterium tuberculosis H37Rv	885326
NP_215321.1	CDS	cpsY	NC_000962.2	899732	901330	R	Rv0806c, (MTCY07H7A.03), len: 532 aa. Possible cpsY, UDP-glucose-4-epimerase (EC 5.1.3.2), equivalent to Q50025|CPSY probable UDP-glucose-4-epimerase from Mycobacterium leprae (542 aa), FASTA scores: opt: 2964, E(): 0, (82.3% identity in 530 aa overlap). Also similar to AAC38286.1|AF019760|SACB CpsY homolog (involved in meningococcal capsule biosynthesis) from Neisseria meningitidis serogroup A (545 aa); Q51151 CAPSULE GENE COMPLEX UPD-GLUCOSE-4-EPIMERASE (GALE) from Neisseria meningitidis (373 aa), FASTA scores: opt: 496, E(): 9.5e-27, (29.3% identity in 358 aa overlap); C-terminus of CAB75373.1|AL139298 putative transferase from Streptomyces coelicolor (942 aa); and many hypothetical proteins from Streptomyces coelicolor. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY.; UDP-glucose-4-epimerase CpsY	complement(899732..901330)	Mycobacterium tuberculosis H37Rv	885243
NP_215322.1	CDS	Rv0807	NC_000962.2	901635	902024	D	Rv0807, (MTCY07H7A.02c), len: 129 aa. Conserved hypothetical protein, equivalent to O05761|MLCB5_31 HYPOTHETICAL 14.0 kDa PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: E(): 0, (73.4% identity in 128 aa overlap). Also highly similar to BAA89438.1|AB003158|ORF3 HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (132 aa); and C-terminus of SCD25.20|CAB56364.1|AL118514 hypothetical protein from Streptomyces coelicolor (202 aa).; hypothetical protein	901635..902024	Mycobacterium tuberculosis H37Rv	885272
NP_215323.1	CDS	purF	NC_000962.2	902111	903694	D	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase	902111..903694	Mycobacterium tuberculosis H37Rv	885085
NP_215324.1	CDS	purM	NC_000962.2	903725	904819	D	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase	903725..904819	Mycobacterium tuberculosis H37Rv	885134
NP_215325.1	CDS	Rv0810c	NC_000962.2	904905	905087	R	Rv0810c, (MTV043.02c), len: 60 aa. Conserved hypothetical protein, with its N-terminus highly similar to NP_302445.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (62 aa); and AL118514|SCD25_24 hypothetical protein from Streptomyces coelicolor (84 aa), FASTA scores: opt: 180, E(): 5.7e-07, (51.8% identity in 56 aa overlap). TBparse score is 0.876.; hypothetical protein	complement(904905..905087)	Mycobacterium tuberculosis H37Rv	885410
NP_215326.1	CDS	Rv0811c	NC_000962.2	905234	906340	R	Rv0811c, (MTV043.03c), len: 368 aa. Conserved hypothetical protein, equivalent to U2266F|U15182|MLU15182_13 HYPOTHETICAL PROTEIN from Mycobacterium leprae (366 aa), FASTA scores: opt: 1870, E(): 0, (77.4% identity in 367 aa overlap). Also highly similar to BAA89441.1|AB003158|ORF4 HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (359 aa); and CAB94085.1|AL358692 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (321 aa). TBparse score is 0.912.; hypothetical protein	complement(905234..906340)	Mycobacterium tuberculosis H37Rv	885401
YP_177757.1	CDS	Rv0812	NC_000962.2	906423	907292	D	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase	906423..907292	Mycobacterium tuberculosis H37Rv	885397
NP_215328.1	CDS	Rv0813c	NC_000962.2	907338	908018	R	Rv0813c, (MTV043.05c), len: 226 aa. Conserved hypothetical protein, highly similar to U15182|MLU15182_16 HYPOTHETICAL PROTEIN from Mycobacterium leprae (242 aa), FASTA scores: opt: 1191, E(): 0, (78.3% identity in 226 aa overlap); and NP_302442.1|NC_002677 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (228 aa). Also similar to AB94083.1|AL358692|SCD66.16 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (191 aa); and Rv2717c|MTCY05A6_37 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (164 aa), FASTA score: (30.4% identity in 171 aa overlap).; hypothetical protein	complement(907338..908018)	Mycobacterium tuberculosis H37Rv	885395
NP_215329.1	CDS	sseC2	NC_000962.2	908181	908483	R	Rv0814c, (MTV043.06c, O05794), len: 100 aa. sseC2, conserved hypothetical protein, highly similar to AAA62972.1|U15182|MLU15182_17 hypothetical protein from Mycobacterium leprae (143 aa), FASTA scores: opt: 545, E(): 0, (84.0% identity in 100 aa overlap); and NP_302441.1|NC_002677|Z95150|MTCY164_29 conserved hypothetical protein from Mycobacterium leprae (100 aa), FASTA scores: opt: 647, E(): 0, (100.0% identity in 100 aa overlap). Also highly similar to M29612|SERCYSA_5 rhodanese-like protein from Saccharopolyspora erythraea (101 aa), FASTA scores: opt: 345, E(): 1.2e-18, (57.1% identity in 98 aa overlap); and similar at the C-terminus to the C-terminus of CAB94069.1|AL358692 conserved hypothetical protein from Streptomyces coelicolor (95 aa). Identical second copy present as Rv3118|MTCY164.28|SSEC1 from Mycobacterium tuberculosis (100 aa) (100.0% identity in 100 aa overlap). TBparse score is 0.853.; hypothetical protein	complement(908181..908483)	Mycobacterium tuberculosis H37Rv	885435
NP_215330.1	CDS	cysA2	NC_000962.2	908485	909318	R	Rv0815c, (MTV043.07c, MT0837, O05793), len: 277 aa. Probable cysA2 (alternate gene name: sseC4), thiosulfate sulfurtransferase (EC 2.8.1.1) (see Wooff et al., 2002), equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE PUTATIVE SULFURTRANSFERASE THIOSULFATE from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER PUTATIVE THIOSULFATE SULFURTRANSFERASE from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa); NP_293941.1|NC_001263 thiosulfate sulfurtransferase from Deinococcus radiodurans (286 aa); etc. Identical second copy present as Rv3117|MTCY164.27|MT3199|O05793|cysA3 (277 aa) (100.0% identity in 277 aa overlap). Contains PS00683 Rhodanese C-terminal signature at C-terminus. BELONGS TO THE RHODANESE FAMILY. TBparse score is 0.901.; sseC4; thiosulfate sulfurtransferase CysA2	complement(908485..909318)	Mycobacterium tuberculosis H37Rv	885449
NP_215331.1	CDS	thiX	NC_000962.2	909611	910033	R	Rv0816c, (MTV043.08c), len: 140 aa. Probable thiX, thioredoxin (EC 1.-.-.-), equivalent to ThiX|U15182|MLU15182_21 thioredoxin from Mycobacterium leprae (172 aa), FASTA scores: opt: 556, E(): 8.8e-31, (63.8% identity in 141 aa overlap); and similar to AAL08576.1|AF418548_2|AF418548 thioredoxin from Mycobacterium avium subsp. paratuberculosis (117 aa). Also similar to other bacterial thioredoxins e.g. CAB95303.1|AL359779 putative thioredoxin from Streptomyces coelicolor (126 aa); P33791|THIO_STRAU|TRX|TRXA THIOREDOXIN from Streptomyces aureofaciens (106 aa); etc. And similar to Rv3914|MT4033|MTV028.05|NP_218431.1|NC_000962|trxC THIOREDOXIN (TRX) (MPT46) from Mycobacterium tuberculosis (116 aa). Has hydrophobic stretch at N-terminus. SEEMS TO BELONG TO THE THIOREDOXIN FAMILY. TBparse score is 0.919.; thioredoxin ThiX	complement(909611..910033)	Mycobacterium tuberculosis H37Rv	885087
NP_215332.1	CDS	Rv0817c	NC_000962.2	910030	910842	R	Rv0817c, (MTV043.09c), len: 270 aa. Probable conserved exported protein, with N-terminal signal sequence, equivalent (but shorter 13 aa) to U15182|MLU15182_22|U2266M probable exported protein from Mycobacterium leprae (283 aa), FASTA scores: opt: 1287, E(): 0, (73.0% identity in 270 aa overlap). TBparse score is 0.896.; hypothetical protein	complement(910030..910842)	Mycobacterium tuberculosis H37Rv	885440
NP_215333.1	CDS	Rv0818	NC_000962.2	910972	911739	D	Rv0818, (MTV043.10), len: 255 aa. Probable transcriptional regulatory protein, highly similar to Q05943|GLNR_STRCO|L03213|STMGLNR_1|SCD84.26c TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (267 aa), FASTA scores: opt: 945, E(): 0, (61.5 identity in 239 aa overlap); and similar to others from other organisms. Also similar to Rv2884|MTCY274.15|Z74024 from Mycobacterium tuberculosis (252 aa), FASTA scores: opt: 662, E(): 0, (47.8% identity in 226 aa overlap). TBparse score is 0.889.; transcriptional regulatory protein	910972..911739	Mycobacterium tuberculosis H37Rv	885144
NP_215334.1	CDS	Rv0819	NC_000962.2	911736	912683	D	Rv0819, (MTV043.11), len: 315 aa. Conserved hypothetical protein, equivalent to U2266N|U15182|MLU15182_24 HYPOTHETICAL PROTEIN from Mycobacterium leprae (312 aa), FASTA scores: opt: 1540, E(): 0, (75.2% identity in 314 aa overlap). Also highly similar to CAB88484.1|AL353816 putative acetyltransferase from Streptomyces coelicolor (309 aa). TBparse score is 0.893; hypothetical protein	911736..912683	Mycobacterium tuberculosis H37Rv	885251
NP_215335.1	CDS	phoT	NC_000962.2	912726	913502	D	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein	912726..913502	Mycobacterium tuberculosis H37Rv	885136
NP_215336.1	CDS	phoY2	NC_000962.2	913558	914199	R	Rv0821c, (MTV043.13c), len: 213 aa. Probable phoY2, phosphate-transport system regulatory protein, highly similar to PhoY|MLU15182_29|U15182 phosphate transport system regulator from Mycobacterium leprae (222 aa), FASTA scores: opt: 1268, E(): 0, (93.0% identity in 213 aa overlap). Also similar to others e.g. NP_384620.1|NC_003047 PROBABLE PHOSPHATE TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATOR PROTEIN from Sinorhizobium meliloti (237 aa); etc. Also highly similar to MTCI418A.03c|Z96070|PhoY1 PROBABLE PHOSPHATE TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATOR PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 937, E(): 0, (63.4% identity in 213 aa overlap). BELONGS TO THE PHOU FAMILY. TBparse score is 0.910.; phosphate transport regulator	complement(913558..914199)	Mycobacterium tuberculosis H37Rv	885270
NP_215337.1	CDS	Rv0822c	NC_000962.2	914257	916311	R	Rv0822c, (MTV043.14c), len: 684 aa. Conserved hypothetical protein, highly similar in the region between aa 370 - 580 to U2266O|U15182|MLU15182_30 HYPOTHETICAL PROTEIN from Mycobacterium leprae (222 aa), FASTA scores: opt: 819, E(): 0, (60.6% identity in 221 aa overlap). More extended similarity to Rv3267|Z92771|MTCY71_7 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 434, E(): 2.2e-17, (26.6% identity in 541 aa overlap), and Rv3484. Also similar to various proteins, preferiously putative membrane proteins and membrane-bound regulatory proteins e.g. CAC44512.1|AL596138 putative membrane protein from Streptomyces coelicolor (524 aa); U56901|BSU56901_1 regulatory protein from Bacillus subtilis (391 aa), FASTA scores: opt: 225, E(): 1.3e-05, (24.7% identity in 340 aa overlap). Contains hydrophobic stretch (aa 160-195) and PS00041 Bacterial regulatory proteins, araC family signature. TBparse score is 0.904.; hypothetical protein	complement(914257..916311)	Mycobacterium tuberculosis H37Rv	885374
NP_215338.1	CDS	Rv0823c	NC_000962.2	916477	917646	R	Rv0823c, (MTV043.15c), len: 389 aa. Possible transcriptional regulator (resembles nitrogen regulation protein), equivalent (but longer 24 aa in N-terminus) to MLU15182_31|U15182|NtrB NtrB protein from Mycobacterium leprae (384 aa), FASTA scores: opt: 2070, E(): 0, (82.3% identity in 384 aa overlap) (see citation below). Also highly similar to CAB63312.1|AL133471|SCC82.03c hypothetical protein from Streptomyces coelicolor (406 aa); and to many transcriptional regulators members of UPF0034 FAMILY (NIFR3/SMM1) e.g. D26185|BAC180K_143 protein similar to transcriptional regulator (nitrogen regulation protein) from Bacillus subtilis (333 aa), FASTA scores: opt: 609, E(): 1.4e-32, (38.3% identity in 326 aa overlap); NP_349795.1|NC_003030 NifR3 family enzyme from Clostridium acetobutylicum (321 aa); etc. Contains PS01136 Uncharacterized protein family UPF0034 signature. TBparse score is 0.908.; transcriptional regulatory protein	complement(916477..917646)	Mycobacterium tuberculosis H37Rv	885380
YP_177758.1	CDS	desA1	NC_000962.2	917734	918750	R	Rv0824c, (MTV043.16c), len: 338 aa. Probable desA1 (alternate gene name: des), acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.99.6) (see Jackson et al., 1997), equivalent to U15182|MLU15182_32 acyl-[ACP] desaturase from Mycobacterium leprae (338 aa), FASTA scores: opt: 1880, E(): 0, (79.9% identity in 338 aa overlap); and highly similar in part to fragment CAB96061.1|AJ250019 Steroyl-ACP-desaturase from Mycobacterium avium subsp. paratuberculosis (93 aa). Also similar to other fatty acid desaturases e.g. T35035 probable acyl-[acyl-carrier protein] desaturase from Streptomyces coelicolor (328 aa); Q40731|STAD_ORYSA ACYL-[ACYL-CARRIER PROTEIN] DESATURASE PRECURSOR from Oryza sativa (Rice) (390 aa); etc. Also highly similar to desA2|Rv1094 from Mycobacterium tuberculosis (275 aa). Contains PS00225 Crystallins beta and gamma 'Greek key' motif signature. BELONGS TO THE FATTY ACID DESATURASE FAMILY. COFACTOR: FERREDOXIN, FERREDOXIN NADPH REDUCTASE, AND NADPH. TBparse score is 0.898.; des; acyl-[acyl-carrier protein] desaturase	complement(917734..918750)	Mycobacterium tuberculosis H37Rv	885444
NP_215340.1	CDS	Rv0825c	NC_000962.2	918912	919553	R	Rv0825c, (MTV043.17c), len: 213 aa. Conserved hypothetical protein, highly similar, but in part (between aa 43-96) to fadD27|Rv0275c|MTV035.03 PUTATIVE FATTY-ACID-CoA LIGASE from Mycobacterium tuberculosis (241 aa), FASTA scores: E(): 7.3e-09, (32.6% identity in 190 aa overlap). Also shows similarity with other proteins from Mycobacterium tuberculosis e.g. Rv0078|AL0214|MTV030_22 (201 aa), FASTA scores: opt:118, E(): 0.32, (34.5% identity in 113 aa overlap); etc. TBparse score is 0.914.; hypothetical protein	complement(918912..919553)	Mycobacterium tuberculosis H37Rv	885354
NP_215341.1	CDS	Rv0826	NC_000962.2	919634	920689	D	Rv0826, (MTV043.18), len: 351 aa. Conserved hypothetical protein, similar to CAB94053.1|AL358672|SC7A12.06 hypothetical protein from Streptomyces coelicolor (300 aa); and NP_421372.1|NC_002696 hypothetical protein from Caulobacter crescentus (299 aa). Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv1645c|Z85982|MTCY06H11.09 (351 aa), FASTA scores: opt: 1199, E(): 0, (57.5% identity in 299 aa overlap); Rv2237; Rv0276; etc. TBparse score is 0.918.; hypothetical protein	919634..920689	Mycobacterium tuberculosis H37Rv	885360
NP_215342.1	CDS	Rv0827c	NC_000962.2	920741	921133	R	Rv0827c, (MTV043.19c), len: 130 aa. Probable transcriptional regulator, similar to many e.g. CAC42856.1|AL592292 putative regulatory protein from Streptomyces coelicolor (115 aa); NP_301626.1|NC_002677 putative ArsR-family transcriptional regulator from Mycobacterium leprae (140 aa); BSUB0011_75|O31844|Z99114 YOZA PROTEIN from Bacillus subtilis (107 aa), FASTA scores: opt: 208, E(): 3.2e-08, (35.5% identity in 93 aa overlap); etc. Also similar to MTCY27.22c|Z95208 from Mycobacterium tuberculosis (135 aa), FASTA scores: opt: 201, E(): 1.2e-07, (35.7% identity in 98 aa overlap). Contains probable helix-turn helix motif from aa 42-63 (Score 1300, +3.61 SD). BELONGS TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.907.; transcriptional regulatory protein	complement(920741..921133)	Mycobacterium tuberculosis H37Rv	885375
NP_215343.1	CDS	Rv0828c	NC_000962.2	921191	921613	R	Rv0828c, (MTV043.20c), len: 140 aa. Possible deaminase (EC 3.5.-.-), with its N-terminus highly similar to middle part of NP_302602.1|NC_002677 possible cytidine/deoxycytidylate deaminase from Mycobacterium leprae (171 aa). Also similar to other deaminases e.g. CAC18715.2|AL451182 putative deaminase from Streptomyces coelicolor (167 aa); NP_251189.1|NC_002516 probable deaminase from Pseudomonas aeruginosa (151 aa); NP_108387.1|NC_002678 nitrogen fixation protein gene from Mesorhizobium loti (149 aa); etc. Also similar to many conserved hypothetical proteins e.g. NP_389200.1|NC_000964 hypothetical protein from Bacillus subtilis (156 aa), FASTA scores: E(): 1.3e-07, (38.9% identity in 95 aa overlap); etc. And similar to Rv3752c possible deaminase from Mycobacterium tuberculosis. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY.; deaminase	complement(921191..921613)	Mycobacterium tuberculosis H37Rv	885265
NP_215344.1	CDS	Rv0829	NC_000962.2	921575	921865	D	Rv0829, (MTV043.21), len: 96 aa. Possible transposase for IS1605' (fragment), similar to C-terminal end of many mycobacterial transposases and hypothetical proteins e.g. Z74024|MTCY274_16 from Mycobacterium tuberculosis (460 aa), FASTA scores: opt: 668, E(): 6.2e-32, (98.9% identity in 93 aa overlap); MTV002_57|O33333 TRANSPOSASE from Mycobacterium tuberculosis ; L07627|SERRY1_1 insertion element IS1136 from Saccharopolyspora erythraea (90 aa), FASTA score: (34.9% identity in 83 aa overlap).; hypothetical protein	921575..921865	Mycobacterium tuberculosis H37Rv	885403
NP_215345.1	CDS	Rv0830	NC_000962.2	921970	922875	D	Rv0830, (MTV043.22), len: 301 aa. Conserved hypothetical protein, member of Mycobacterium tuberculosis protein family consisting of the proteins Rv0726c, Rv0731c, Rv3399, Rv1729c|Z81360|MTCY4C12_14c (312 aa), FASTA scores: opt: 1014, E(): 0, (54.1% identity in 292 aa overlap); etc. TBparse score is 0.917.; hypothetical protein	921970..922875	Mycobacterium tuberculosis H37Rv	885886
NP_215346.1	CDS	Rv0831c	NC_000962.2	922894	923709	R	Rv0831c, (MTV043.23c), len: 271 aa. Conserved hypothetical protein, similar to Rv0347|MTY13E10_7|Z95324 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (328 aa), FASTA scores: opt: 426, E(): 2.6e-21, (33.6% identity in 262 aa overlap). TBparse score is 0.939.; hypothetical protein	complement(922894..923709)	Mycobacterium tuberculosis H37Rv	885349
YP_177759.1	CDS	PE_PGRS12	NC_000962.2	924951	925364	D	Rv0832, (MTV043.24), len: 137 aa. Member of the Mycobacterium tuberculosis PE family, possibly PGRS subfamily of gly-rich proteins (see citation below), highly similar to many others e.g. MTCY1A11.25c|Z78020 (498 aa), FASTA scores: opt: 529, E(): 5.2e-22, (61.8% identity in 136 aa overlap); etc. Appears to have incurred frameshift as next ORF should be continuation; sequence has been checked but no error found. TBparse score is 0.875.; PE-PGRS family protein	924951..925364	Mycobacterium tuberculosis H37Rv	885236
YP_177760.1	CDS	PE_PGRS13	NC_000962.2	925361	927610	D	Rv0833, (MTV043.25), len: 749 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), but lacking N-terminal domain (present in preceding ORF), possibly due to frameshift. Similar in part to many others e.g. MTCY28_25|Z95890 (914 aa), FASTA scores: opt: 2726, E(): 0, (60.1% identity in 776 aa overlap); etc. TBparse score is 0.859.; PE-PGRS family protein	925361..927610	Mycobacterium tuberculosis H37Rv	885391
YP_177761.1	CDS	PE_PGRS14	NC_000962.2	927837	930485	R	Rv0834c, (MTV043.26c), len: 882 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002), highly similar to many others e.g. MTCY493_4|Z95844 (1329 aa), FASTA scores: opt: 2577, E(): 0, (52.0% identity in 950 aa overlap); etc. TBparse score is 0.860. Thought to be differentially expressed within host cells (see Triccas et al., 1999).; PE-PGRS family protein	complement(927837..930485)	Mycobacterium tuberculosis H37Rv	885369
NP_215350.1	CDS	lpqQ	NC_000962.2	930953	931597	D	Rv0835, (MTV043.27), len: 214 aa. Possible lpqQ, lipoprotein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.944.; lipoprotein LpqQ	930953..931597	Mycobacterium tuberculosis H37Rv	885883
NP_215351.1	CDS	Rv0836c	NC_000962.2	932279	932932	R	Rv0836c, (MTV043.29c), len: 217 aa (start uncertain). Hypothetical unknown protein. TBparse score is 0.903.; hypothetical protein	complement(932279..932932)	Mycobacterium tuberculosis H37Rv	885356
NP_215352.1	CDS	Rv0837c	NC_000962.2	933003	934031	R	Rv0837c, (MTV043.30c), len: 342 aa. Hypothetical unknown protein. TBparse score is 0.941.; hypothetical protein	complement(933003..934031)	Mycobacterium tuberculosis H37Rv	885109
NP_215353.1	CDS	lpqR	NC_000962.2	934720	935490	D	Rv0838, (MTV043.31), len: 256 aa. Probable lpqR, conserved lipoprotein. Similar (except in N-terminus) to hypothetical proteins and D-alanyl-D-alanine dipeptidases e.g. NP_416005.1|NC_000913 hypothetical protein from Escherichia coli strain K12 (193 aa); NP_421076.1|NC_002696 D-alanyl-D-alanine dipeptidase from Caulobacter crescentus (212 aa); Q06241|VANX_ENTFC D-ALANYL-D-ALANINE DIPEPTIDASE from Enterococcus faecium (202 aa), FASTA scores: opt: 198, E(): 1.9e-05, (28.1% identity in 199 aa overlap); etc. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.931.; lipoprotein LpqR	934720..935490	Mycobacterium tuberculosis H37Rv	885417
NP_215354.1	CDS	Rv0839	NC_000962.2	935577	936389	D	Rv0839, (MTV043.32), len: 270 aa. Conserved hypothetical protein, similar to various hypothetical proteins or methyltransferases from yeast and bacteria e.g. T34740|SC1E6.19c|AL033505|SC1E6_19 hypothetical protein from Streptomyces coelicolor (273 aa), FASTA scores: opt: 1102, E(): 0, (58.6% identity in 263 aa overlap); T38024|Z98598|SPAC1B3.06c hypothetical protein from Schizosaccharomyces pombe (278 aa), FASTA scores: opt: 562, E(): 1.9e-3, (36.4% identity in 269 aa overlap); JC6531 avermectin B 5-O-methyltransferase (EC 2.1.1.-) from Streptomyces avermitilis (283 aa); etc. Also similar to other Mycobacterium tuberculosis hypothetical proteins that may be methyltransferases e.g. Rv1523, Rv2952, Rv1405c, etc. TBparse score is 0.926.; hypothetical protein	935577..936389	Mycobacterium tuberculosis H37Rv	885255
NP_215355.1	CDS	pip	NC_000962.2	936457	937317	R	Rv0840c, (MTV043.33c), len: 286 aa. Possible pip, proline iminopeptidase (EC 3.4.11.5), similar to many e.g. P46541|PIP_BACCO PROLINE IMINOPEPTIDASE from BACILLUS COAGULANS (288 aa), FASTA scores: opt: 657, E(): 0, (37.6% identity in 282 aa overlap); NP_386922.1|NC_003047 PUTATIVE PROLINE IMINOPEPTIDASE PROTEIN from Sinorhizobium meliloti (296 aa); etc. BELONGS TO PEPTIDASE FAMILY S33. TBparse score is 0.948.; proline iminopeptidase	complement(936457..937317)	Mycobacterium tuberculosis H37Rv	885611
YP_177634.1	CDS	Rv0841	NC_000962.2	937593	937835	D	Rv0841, 80 aa. Conserved transmembrane protein, highly similar to C-terminus of next ORF Rv0842|O53854 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis (442 aa), FASTA scores: opt: 246, E(): 3.3e-10, (59.7% identity in 72 aa overlap). Replace previous Rv0841c.; transmembrane protein	937593..937835	Mycobacterium tuberculosis H37Rv	3205068
NP_215357.1	CDS	Rv0842	NC_000962.2	938112	939404	D	Rv0842, (MT0864, MTV043.35), len: 430 aa. Probable conserved integral membrane protein, showing similarity with other integral membrane proteins e.g. P28246|BCR_ECOLI BICYCLOMYCIN RESISTANCE PROTEIN from EScherichia coli (396 aa), FASTA scores: opt: 216, E(): 5.4e-07, (23.7% identity in 376 aa overlap); etc. TBparse score is 0.922.; integral membrane protein	938112..939404	Mycobacterium tuberculosis H37Rv	885616
NP_215358.1	CDS	Rv0843	NC_000962.2	939388	940392	D	Rv0843, (MTV043.36), len: 334 aa. Probable dehydrogenase (EC 1.-.-.-), similar to various dehydrogenases e.g. Q46142|Q46142 TPP-DEPENDENT ACETOIN DEHYDROGENASE (326 aa), FASTA scores: opt: 500, E(): 2.4e-26, (32.3% identity in 300 aa overlap); P51267|ODPA_PORPU PYRUVATE DEHYDROGENASE E1 COMPONENT from Porphyra purpurea (344 aa), FASTA scores: opt: 451, E(): 4.7e-23, (29.6% identity in 311 aa overlap); etc. Also similar to Rv2497c|pdhA pyruvate dehydrogenase E1 component from Mycobacterium tuberculosis (367 aa). TBparse score is 0.928.; dehydrogenase	939388..940392	Mycobacterium tuberculosis H37Rv	885554
NP_215359.1	CDS	narL	NC_000962.2	940456	941106	R	Rv0844c, (MTV043.37c), len: 216 aa. Possible narL, nitrate/nitrite response regulator protein, similar to many e.g. CAB44989.1|AJ131854 NarL protein from Pseudomonas stutzeri (218 aa); CAA75536.1|Y15252 nitrate/nitrite regulatory protein from Pseudomonas aeruginosa (216 aa); PCC6803|D64005|SYCSLRG_24 NarL protein from Synechocystis sp. (209 aa), FASTA scores: opt: 438, E(): 1.5e-23, (34.6% identity in 208 aa overlap); etc. Also similar to unidentified regulator e.g. CAB76009.1|AL157916 putative two-component system response regulator from Streptomyces coelicolor (224 aa); etc. Contains probable helix-turn helix motif from aa 170-191 (Score 1124, +3.02 SD). TBparse score is 0.890.; nitrate/nitrite response transcriptional regulatory protein NarL	complement(940456..941106)	Mycobacterium tuberculosis H37Rv	885603
NP_215360.1	CDS	Rv0845	NC_000962.2	941190	942467	D	Rv0845, (MTV043.38), len: 425 aa. Possible two-component sensor kinase (EC 2.7.-.-), with its C-terminus similar to C-terminal part of others e.g. NP_294951.1|NC_001263 two-component sensor histidine kinase from Deinococcus radiodurans (469 aa); CAC32293.1|AL583943 putative two component system histidine kinase from Streptomyces coelicolor (404 aa); NP_464546.1|NC_003210 protein similar to two-component sensor histidine kinase from Listeria monocytogenes (352 aa); BSUB0017_193|Z9912 two-component sensor kinase from Bacillus subtilis (360 aa), FASTA scores: opt: 275, E(): 1.6e-11, (30.3% identity in 234 aa overlap); etc. TBparse score is 0.938.; two component sensor kinase	941190..942467	Mycobacterium tuberculosis H37Rv	885218
NP_215361.1	CDS	Rv0846c	NC_000962.2	942680	944194	R	Rv0846c, (MTV043.39c), len: 504 aa. Probable oxidase (EC 1.-.-.-), showing similarity with several oxidases, mainly L-ascorbate oxidases and copper resistance proteins A (precursors) e.g. P24792|ASO_CUCMA L-ASCORBATE OXIDASE PRECURSOR (ASCORBASE) (EC 1.10.3.3) from Cucurbita maxima (Pumpkin) (Winter squash) (579 aa), FASTA scores: opt: 423, E(): 5.8e-18, (28.4% identity in 493 aa overlap); AF010496|AF010496_32 potential multicopper oxidase from Rhodobacter capsulatus (491 aa), FASTA scores: opt: 490, E(): 2.7e-22, (28.8% identity in 510 aa overlap); 47452|PCOA_ECOLI COPPER RESISTANCE PROTEIN A PRECURSOR (BELONGS TO THE FAMILY OF MULTICOPPER OXIDASES) from Escherichia coli strain K12 (605 aa); etc. Contains PS00080 Multicopper oxidases signature 2 at C-terminus. SEEMS TO BELONG TO THE FAMILY OF MULTICOPPER OXIDASES. TBparse score is 0.904.; oxidase	complement(942680..944194)	Mycobacterium tuberculosis H37Rv	885207
NP_215362.1	CDS	lpqS	NC_000962.2	944343	944735	D	Rv0847, (MTV043.40), len: 130 aa. Probable lpqS, lipoprotein. Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.920.; lipoprotein LpqS	944343..944735	Mycobacterium tuberculosis H37Rv	885051
YP_177762.1	CDS	cysK2	NC_000962.2	944938	946056	D	Rv0848, (MTV043.41), len: 372 aa. Possible cysK2, cysteine synthase A (EC 4.2.99.8), but could be also a cysteine synthase B (EC 4.2.99.8) cysM2-product, similar to many e.g. NP_109408.1|NC_002682 cysteine synthase from Mesorhizobium loti (357 aa); Q44004|CYSM_ALCEU CYSTEINE SYNTHASE from Alcaligenes eutrophus strain CH34 (Ralstonia eutropha) (339 aa), FASTA scores: opt: 511, E(): 1.7e-25, (35.0% identity in 314 aa overlap); etc. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. COFACTOR: PYRIDOXAL PHOSPHATE. Note that previously known as cysM3.; cysM3; cysteine synthase A CysK2	944938..946056	Mycobacterium tuberculosis H37Rv	885545
NP_215364.1	CDS	Rv0849	NC_000962.2	946056	947315	D	Rv0849, (MTV043.42), len: 419 aa. Probable conserved integral membrane transport protein, possibly member of major facilitator superfamily (MFS) involved in transport of drug, showing similarity with others e.g. T35055 probable transport system permease protein from Streptomyces coelicolor (436 aa); NP_295031.1|NC_001263 major facilitator family protein from Deinococcus radiodurans (458 aa); NP_455659.1|NC_003198 putative membrane transporter from Salmonella enterica subsp. enterica serovar Typhi (402 aa); etc. TBparse score is 0.908.; integral membrane transport protein	946056..947315	Mycobacterium tuberculosis H37Rv	885111
NP_215365.1	CDS	Rv0850	NC_000962.2	947312	947644	D	Rv0850, (MTV043.43), len: 110 aa. Putative transposase (fragment), similar in part to others e.g. Q45144|Q4514 TRANSPOSABLE ELEMENT IS31831 (436 aa), FASTA scores: opt: 175, E(): 4.3e-05, (38.6% identity in 57 aa overlap); etc.; transposase	947312..947644	Mycobacterium tuberculosis H37Rv	885054
NP_215366.1	CDS	Rv0851c	NC_000962.2	947641	948468	R	Rv0851c, (MTV043.44c), len: 275 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to many e.g. Q01198|LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC 1.1.1.-)(SDR FAMILY) from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (305 aa); D11473|PSELIG_1 C alpha-dehydrogenase from P. paucimobilis (305 aa), FASTA scores: opt: 468, E(): 4.9e-23, (30.8% identity in 279 aa overlap); NP_421969.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (278 aa); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is 0.913.; short chain dehydrogenase	complement(947641..948468)	Mycobacterium tuberculosis H37Rv	885550
NP_215367.1	CDS	fadD16	NC_000962.2	948559	949395	D	Rv0852, (MTV043.45), len: 278 aa. Possible fadD16, fatty-acid-CoA synthetase (EC 6.2.1.-), similar in part to various CoA ligases e.g. P18163|LCFB_RAT LONG-CHAIN-FATTY-ACID--CoA LIGASE from Rattus norvegicus (Rat) (699 aa); D49366|LEP4CCOALA_1 4-coumarate:CoA ligase from Lithospermum erythrorhizon (636 aa), FASTA scores: opt: 134, E(): 0.15, (26.8% identity in 213 aa overlap); orgp|L09229|HUMFACAL_1 long-chain acyl-coenzyme A from homo sapiens (human) (699 aa), FASTA score: (50.0% identity in 40 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.; fatty-acid-CoA ligase	948559..949395	Mycobacterium tuberculosis H37Rv	885044
NP_215368.1	CDS	pdc	NC_000962.2	949436	951118	R	Rv0853c, (MTV043.46c), len: 560 aa. Probable pdc, pyruvate or indole-pyruvate decarboxylase (EC 4.1.1.-), equivalent to NP_302424.1|NC_002677 pyruvate (or indolepyruvate) decarboxylase from Mycobacterium leprae (569 aa). Also highly similar to others e.g. AAB06571.1|L80006 indolepyruvate decarboxylase from Pantoea agglomerans (550 aa); Q12629|DCPY_KLULA PYRUVATE DECARBOXYLASE (EC 4.1.1.1) from Kluyveromyces marxianus var. lactis (563 aa); P71323 INDOLEPYRUVATE DECARBOXYLASE (EC 4.1.1.74) from Enterobacter herbicola (550 aa), FASTA scores: opt: 1642, E(): 0, (48.1% identity in 547 aa overlap); P23234|DCIP_ENTCL INDOLE-3-PYRUVATE DECARBOXYLASE (INDOLEPYRUVATE DECARBOXYLASE) from Enterobacter cloacae (552 aa), FASTA scores: opt: 1596, E(): 0, (46.8% identity in 551 aa overlap); etc. Contains PS00187 Thiamine pyrophosphate enzymes signature and PS00017 ATP/GTP-binding site motif A (P-loop). COFACTOR: THIAMINE PYROPHOSPHATE. TBparse score is 0.910.; pyruvate or indole-3-pyruvate decarboxylase pdc	complement(949436..951118)	Mycobacterium tuberculosis H37Rv	885576
NP_215369.1	CDS	Rv0854	NC_000962.2	951183	951626	D	Rv0854, (MTV043.47), len: 147 aa. Conserved hypothetical protein, similar to several hypothetical protein from Mycobacterium leprae e.g. NP_301674.1|NC_002677 (144 aa); NP_302683.1|NC_002677|Z95398|MLCL622.27c (156 aa), FASTA scores: opt: 193, E(): 1.6e-06, (24.6% identity in 134 aa overlap); NP_301218.1|NC_002677 (146 aa); MTCI28.04|Z97050 (184 aa), FASTA scores: opt: 171, E(): 5.8e-05, (21.5% identity in 135 aa overlap). Also similar to SC6G10.02c|T35511|AL049497|SC6G10_2 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 344, E(): 6.1e- 17, (37.6% identity in 141 aa overlap). And similar to many proteins from Mycobacterium tuberculosis e.g. downstreams ORFs Rv0856 and Rv0857, etc. TBparse score is 0.903.; hypothetical protein	951183..951626	Mycobacterium tuberculosis H37Rv	885127
NP_215370.1	CDS	far	NC_000962.2	951632	952711	D	Rv0855, (MTV043.48), len: 359 aa. Probable far, fatty acid-CoA racemase (EC 5.1.-.-), highly similar to CAB08122.1|Z94723 unknown protein from Mycobacterium leprae (253 aa) (C-terminus shorter). Also similar to many eukaryotic and bacteria racemases e.g. T35425 probable fatty acid CoA racemase from Streptomyces coelicolor (387 aa); P70473|AMAC_RAT ALPHA-METHYLACYL-CoA RACEMASE (2-METHYLACYL-CoA RACEMASE) (2-ARYLPROPIONYL-COA EPIMERASE) (EC 5.1.99.4) from Rattus norvegicus (Rat) (382 aa); NP_103687.1|NC_002678 probable fatty acid Co-A racemase from Mesorhizobium loti (389 aa); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Rv1143|MTCI65.10|MCR from Mycobacterium tuberculosis (360 aa), FASTA scores: opt: 1373, E(): 0, (56.8% identity in 359 aa overlap), Rv1866|MTCY359.07 (C-terminal half) (778 aa), Rv3272 (360 aa). TBparse score is 0.899.; fatty-acid-CoA racemase	951632..952711	Mycobacterium tuberculosis H37Rv	885790
NP_215371.1	CDS	Rv0856	NC_000962.2	952825	953229	D	Rv0856, (MTV043.49), len: 134 aa. Conserved hypothetical protein, showing weak similarity with NP_301674.1| (NC_002677) conserved hypothetical protein from Mycobacterium leprae (144 aa); and SC6G10.02c|T35511 hypothetical protein from Streptomyces coelicolor (144 aa). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. neighbouring ORF downstream Rv0857 CONSERVED HYPOTHETICAL PROTEIN (126 aa), FASTA scores: E(): 7.4e-27, (62.0% identity in 100 aa overlap); neighbouring ORF Rv0854|MTV043_47 CONSERVED HYPOTHETICAL PROTEIN (147 aa), FASTA scores: E(): 1.6e-15, (36.6% identity in 123 aa overlap), MTCI28.04|Z97050|MTCI28_4 (184 aa), FASTA scores: opt: 127, E(): 0.036, (26.0% identity in 127 aa overlap); and MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 123, E(): 0.06, (26.4% identity in 125 aa overlap). TBparse score is 0.913.; hypothetical protein	952825..953229	Mycobacterium tuberculosis H37Rv	885783
NP_215372.2	CDS	Rv0857	NC_000962.2	953257	953730	D	Rv0857, (MTV043.50), len: 157 aa. Conserved hypothetical protein, showing weak similarity with Q9X7Y8|SC6G10.02c|T35511 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 215, E(): 7.6e-08, (30.282% identity in 142 aa overlap). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. upstream ORF Rv0856 (134 aa), FASTA scores: opt: 566, E(): 2e-32, (58.15% identity in 129 aa overlap); upstream ORF Rv0854 (147 aa), FASTA scores: opt: 401, E(): 7.2e-21, (41.8% identity in 146 aa overlap); MTCI28.04|Z97050 (184 aa), FASTA scores: opt: 122, E(): 0.031, (29.4% identity in 85 aa overlap); and MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 114, E(): 0.1, (30.9% identity in 55 aa overlap). Length extended since first submission (+33 aa). TBparse score is 0.910.; hypothetical protein	953257..953730	Mycobacterium tuberculosis H37Rv	885078
NP_215373.1	CDS	Rv0858c	NC_000962.2	953727	954920	R	Rv0858c, (MTV043.51c), len: 397 aa. Probable aminotransferase (EC 2.6.1.-), highly similar to others from Eukaryota and bacteria, especially aspartate aminotransferases (transaminases) (EC 2.6.1.1), e.g. NP_177890.1|NC_003070 putative aminotransferase from Arabidopsis thaliana (440 aa); NP_419555.1|NC_002696 aminotransferase class I from Caulobacter crescentus (385 aa); NP_415133.1|NC_000913|AE0001|ECAE000165_8 putative aminotransferase from Escherichia coli strain K12 (386 aa), FASTA scores: opt: 830, E(): 0, (38.0% identity in 389 aa overlap); X99521|TAX99521_1 aspartate aminotransferase from Thermus aquaticus (383 aa), FASTA scores: opt: 702, E(): 0, (34.9% identity in 393 aa overlap); etc. Also similar to other putative aminotransferases from Mycobacterium tuberculosis e.g. Rv2294, Rv3565, etc. TBparse score is 0.907.; aminotransferase	complement(953727..954920)	Mycobacterium tuberculosis H37Rv	885784
NP_215374.1	CDS	fadA	NC_000962.2	955077	956288	D	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase	955077..956288	Mycobacterium tuberculosis H37Rv	885774
NP_215375.1	CDS	fadB	NC_000962.2	956293	958455	D	Rv0860, (MTV043.53), len: 720 aa. Probable fadB, fatty oxidation protein, equivalent to NP_302422.1|NC_002677 putative fatty oxidation complex alpha subunit from Mycobacterium leprae (714 aa). Also highly similar to others and various proteins involved in fatty acid metabolism, e.g. T35429 probable fatty oxidation protein from Streptomyces coelicolor (733 aa); NP_250428.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (714 aa); NP_418895.1|NC_002696 fatty oxidation complex alpha subunit from Caulobacter crescentus (709 aa); P40939|ECHA_HUMAN TRIFUNCTIONAL ENZYME ALPHA SUBUNIT [INCLUDES: LONG-CHAIN ENOYL-CoA HYDRATASE (EC 4.2.1.17); LONG CHAIN 3-HYDROXYACYL-CoA DEHYDROGENASE (EC 1.1.1.35)] from Homo sapiens (763 aa), FASTA scores: opt: 1176, E(): 0, (32.4% identity in 722 aa overlap); P21177|FADB_ECOLI FATTY OXIDATION COMPLEX ALPHA SUBUNIT [INCLUDES: ENOYL-COA HYDRATASE (EC 4.2.1.17); DELTA(3)-CIS-DELTA(2)-TRANS-ENOYL-CoA ISOMERASE (EC 5.3.3.8); 3-HYDROXYACYL-CoA DEHYDROGENASE (EC 1.1.1.35); 3- HYDROXYBUTYRYL-CoA EPIMERASE (EC 5.1.2.3)] from Escherichia coli strain K12 (729 aa), FASTA scores: opt: 873, E(): 0, (33.6% identity in 693 aa overlap); etc. TBparse score is 0.864.; fatty oxidation protein FadB	956293..958455	Mycobacterium tuberculosis H37Rv	885799
NP_215376.1	CDS	ercc3	NC_000962.2	958523	960151	R	Rv0861c, (MTV043.54c), len: 542 aa. Probable ercc3, DNA helicase (EC 3.6.1.-) (see citation below), equivalent to NP_302420.1|NC_002677 probable DNA helicase from Mycobacterium leprae (549 aa). Also highly similar to others (shorter than several eukaryotic enzymes) e.g. NP_218820.1|NC_000919|AE001217|AE0 01217_6 putative DNA repair helicase from Treponema pallidum (606 aa), FASTA scores: opt: 1275, E(): 0, (47.5% identity in 592 aa overlap); Q00578|RA25_YEAST DNA REPAIR HELICASE from Saccharomyces cerevisiae (843 aa), FASTA scores: opt: 777, E(): 0, (30.4% identity in 605 aa overlap); P49135|XPB_MOUSE DNA-REPAIR PROTEIN COMPLEMENTING XP-B CELLS from Mus musculus (Mouse) (783 aa), FASTA scores: opt: 761, E(): 0, (36.3% identity in 375 aa overlap); etc. SEEMS TO BELONG TO THE HELICASE FAMILY. TBparse score is 0.899.; DNA helicase ErcC3	complement(958523..960151)	Mycobacterium tuberculosis H37Rv	885425
NP_215377.1	CDS	Rv0862c	NC_000962.2	960342	962612	R	Rv0862c, (MTV043.55c), len: 756 aa. Conserved hypothetical protein, equivalent to NP_302419.1|NC_002677 possible DNA-binding protein from Mycobacterium leprae (753 aa); and highly similar (except in C-terminus) to MLCB57.01|Z99494|T45333 hypothetical protein from Mycobacterium leprae (>577 aa, truncated), FASTA scores: opt: 3047, E(): 0, (78.9% identity in 578 aa overlap). Also similar in part to SCD12A.03c|AB93395.1|AL357524 hypothetical protein from Streptomyces coelicolor (867 aa).; hypothetical protein	complement(960342..962612)	Mycobacterium tuberculosis H37Rv	885413
NP_215378.1	CDS	Rv0863	NC_000962.2	962599	962880	D	Rv0863, (MTV043.56), len: 93 aa. Conserved hypothetical protein, highly similar to NP_302418.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (74 aa). Also weakly similar in part to U82598|ECU82598_135 HYPOTHETICAL PROTEIN from Escherichia coli, FASTA scores: (32.4% identity in 71 aa overlap); and M74011|YEPYSCOP_8 HYPOTHETICAL PROTEIN from Yersinia enterocolitica (165 aa), FASTA scores: (38.6 identity in 57 aa overlap).; hypothetical protein	962599..962880	Mycobacterium tuberculosis H37Rv	885423
NP_215379.1	CDS	moaC	NC_000962.2	962890	963393	D	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC	962890..963393	Mycobacterium tuberculosis H37Rv	885826
NP_215380.1	CDS	mog	NC_000962.2	963390	963872	D	Rv0865, (MTV043.58), len: 160 aa. Probable mog, molybdopterin biosynthesis MOG protein, highly similar or similar to other molybdenum cofactor biosynthesis proteins e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa); NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa); CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa); P44645|MOG_HAEIN|MOGA|HI0336 MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN from Haemophilus influenzae (197 aa), FASTA scores: opt: 306, E(): 9e-13, (39.6% identity in 139 aa overlap); P28694|MOG_ECOLI MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN from Escherichia coli (195 aa), FASTA scores: opt: 265, E(): 3.6e-10, (34.2 identity in 146 aa overlap); etc. Also highly similar to Rv0984|MTV044.12|MOAB2 POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis (181 aa). TBparse score is 0.914.; molybdopterin biosynthesis Mog protein	963390..963872	Mycobacterium tuberculosis H37Rv	885348
NP_215381.1	CDS	moaE2	NC_000962.2	963869	964294	D	Rv0866, (MTV043.59), len: 141 aa. Probable moaE2, molybdopterin converting factor E (molybdopterin converting factor (subunit 2)), similar to others e.g. Y10817|ANY10817_4|T44853 molybdopterin biosynthesis protein E chain from Arthrobacter nicotinovorans plasmid pAO1 (155 aa), FASTA scores: opt: 460, E(): 3.5e-27, (49.3 identity in 146 aa overlap); CAC01331.1|AL390968 moaE-like protein from Streptomyces coelicolor (152 aa); NP_389313.1|NC_000964 molybdopterin converting factor (subunit 2) from Bacillus subtilis (157 aa); etc. Also highly similar to Rv3119|MOAE1|Z95150|MTCY164_30 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 321, E(): 5.9e-17, (40.9% identity in 132 aa overlap); and O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis (221 aa). TBparse score is 0.889.; molybdenum cofactor biosynthesis protein E2	963869..964294	Mycobacterium tuberculosis H37Rv	885431
NP_215382.1	CDS	rpfA	NC_000962.2	964312	965535	R	Rv0867c, (MTV043.60c), len: 407 aa. Possible rpfA, resuscitation-promoting factor (see citation below). N-terminus highly similar to N-terminal part (1-125 aa) of Z99494|MLCB57_3|NP_302417.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (174 aa), FASTA scores: opt: 785, E(): 1.8e-18, (63.0% identity in 200 aa overlap); and highly similar to C-terminus of NP_301299.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (375 aa); and middle part of NP_302360.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (157 aa). N-terminus also highly similar in part of three secreted proteins from Streptomyces coelicolor e.g. CAC09538.1|AL442120 putative secreted protein (244 aa). Regions highly similar to CAB76321.1|AL158060 putative membrane protein from Streptomyces coelicolor (121 aa); and middle part of CAB09664.1|Z96935 rpf from Micrococcus luteus (220 aa). Also highly similar in part to four resuscitation-promoting factors from Mycobacterium tuberculosis: Rv2450 (172 aa), Rv1009 (362 aa), Rv1884c (176 aa), and Rv2389c (154 aa). Contains a probable secretory signal sequence in N-terminus. TBparse score is 0.902.; resuscitation-promoting factor RpfA	complement(964312..965535)	Mycobacterium tuberculosis H37Rv	885749
NP_215383.1	CDS	moaD2	NC_000962.2	965983	966261	R	Rv0868c, (MTV043.61c), len: 92 aa. Probable moaD2, molybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1)), similar to CAB88494.1|AL353816 putative molybdopterin converting factor from Streptomyces coelicolor (84 aa); and weakly similar to others MoaD proteins e.g. Z99111|BSUB0008_103 from Bacillus subtilis (77 aa), FASTA scores: opt: 86, E(): 2.8, (22.9% identity in 83 aa overlap); etc. Also some similarity with Rv3112|MOAD1|MTCY164.22 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D from Mycobacterium tuberculosis (83 aa), FASTA scores: opt: 113, E(): 0.024, (31.3% identity in 83 aa overlap). TBparse score is 0.917.; molybdenum cofactor biosynthesis protein D	complement(965983..966261)	Mycobacterium tuberculosis H37Rv	885763
NP_215384.1	CDS	moaA	NC_000962.2	966265	967347	R	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A	complement(966265..967347)	Mycobacterium tuberculosis H37Rv	885773
NP_215385.1	CDS	Rv0870c	NC_000962.2	967344	967733	R	Rv0870c, (MTV043.63c), len: 129 aa. Possible conserved integral membrane protein, highly similar to other membrane proteins: putative secreted proteins or hypothetical proteins e.g. CAC08263.1| AL392146 putative integral membrane protein from Streptomyces coelicolor (138 aa); NP_233433.1|NC_002506 conserved hypothetical protein from Vibrio cholerae (143 aa); NP_455572.1|NC_003198 putative membrane protein from Salmonella enterica subsp. enterica serovar Typhi (148 aa); P37065|YCCF_ECOLI HYPOTHETICAL 16.3 kDa PROTEIN from Escherichia coli (148 aa), FASTA scores: opt: 183, E(): 1.9e-06, (36.6% identity in 134 aa overlap); etc. TBparse score is 0.886.; hypothetical protein	complement(967344..967733)	Mycobacterium tuberculosis H37Rv	885709
NP_215386.1	CDS	cspB	NC_000962.2	967898	968305	D	Rv0871, (MTV043.64), len: 135 aa. Probable cspB, cold shock-like protein B, equivalent to Z99494|MLCB57_7|MLCB57.11 probable cold shock protein from Mycobacterium leprae (136 aa), FASTA scores: opt: 787, E(): 0, (86.0% identity in 136 aa overlap). Also highly similar (but often longer than) to others e.g. CAB93399.1|AL357524 cold shock protein B from Streptomyces coelicolor (127 aa); Q45099|CSPD_BACCE COLD SHOCK-LIKE PROTEIN CSPD from Bacillus cereus (66 aa); Y101 81|LLCSPB_1 cold shock protein from Lactococcus lactis (66 aa), FASTA scores: opt: 220, E(): 2.5e-07, (48.3% identity in 60 aa overlap); etc. SEEMS TO BELONG TO THE COLD-SHOCK DOMAIN (CSD) FAMILY. TBparse score is 0.897.; cold shock-like protein B CspB	967898..968305	Mycobacterium tuberculosis H37Rv	885725
YP_177763.1	CDS	PE_PGRS15	NC_000962.2	968424	970244	R	Rv0872c, (MTV043.65c), len: 606 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002), similar to many e.g. MTCY24A1.04c|Z95207 (615 aa), FASTA scores: opt: 2636, E(): 0, (64.6% identity in 619 aa overlap); etc.; PE-PGRS family protein	complement(968424..970244)	Mycobacterium tuberculosis H37Rv	885742
NP_215388.1	CDS	fadE10	NC_000962.2	970505	972457	D	Rv0873, (MTV043.66-MTCY31.01), len: 650 aa. Probable fadE10, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAB91129.1|AL355913 putative acyl CoA dehydrogenase from Streptomyces coelicolor (658 aa); P50544|ACDV_MOUSE ACYL-CoA DEHYDROGENASE from Mus musculus (656 aa); D30647|RATVLCAD_1 very-long-chain Acyl-CoA dehydrogenase from Rattus norvegicus (655 aa), FASTA scores: opt: 675, E(): 0, (33.9% identity in 380 aa overlap); etc.; acyl-CoA dehydrogenase FADE10	970505..972457	Mycobacterium tuberculosis H37Rv	885636
NP_215389.1	CDS	Rv0874c	NC_000962.2	972546	973706	R	Rv0874c, (MTCY31.02c), len: 386 aa. Conserved hypothetical protein, highly similar in part to SPU62616_1 hypothetical protein from Synechococcus sp. (280 aa), FASTA scores: E(): 6.3e-26, (35.2% identity in 264 aa overlap); SYCSLLLH_102 from Synechocystis sp. (447 aa), FASTA scores: E(): 1.1e-18, (29.5% identity in 400 aa overlap). Also highly similar to Rv0628c|MTCY20H10_9 from Mycobacterium tuberculosis (383 aa), FASTA scores: E():0, (81.5% identity in 383 aa overlap).; hypothetical protein	complement(972546..973706)	Mycobacterium tuberculosis H37Rv	885658
NP_215390.1	CDS	Rv0875c	NC_000962.2	973806	974294	R	Rv0875c, (MTCY31.03c), len: 162 aa. Possible conserved exported protein, equivalent to MLCB57_11|O33056 possible exported protein from Mycobacterium leprae (162 aa), FASTA scores: opt: 789, E(): 0, (71.4% identity in 161 aa overlap).; hypothetical protein	complement(973806..974294)	Mycobacterium tuberculosis H37Rv	885669
NP_215391.1	CDS	Rv0876c	NC_000962.2	974291	975937	R	Rv0876c, (MTCY31.04c), len: 548 aa. Possible conserved transmembrane protein, equivalent to MLCB57_12|O33057 possible membrane protein from Mycobacterium leprae (579 aa), FASTA scores: opt: 2850, E(): 0, (81.0% identity in 568 aa overlap). Also highly similar (except in N-terminus) to CAB93403.1|AL357524 putative integral membrane protein from Streptomyces coelicolor (463 aa).; transmembrane protein	complement(974291..975937)	Mycobacterium tuberculosis H37Rv	885562
NP_215392.1	CDS	Rv0877	NC_000962.2	976075	976863	D	Rv0877, (MTCY31.05), len: 262 aa. Conserved hypothetical protein, equivalent to MLCB57_13|O33058 conserved hypothetical protein from Mycobacterium leprae (269 aa), FASTA scores: E(): 0, (80.5% identity in 257 aa overlap). Also highly similar (except in C-terminus) to SCD12A.13|CAB93404.1|AL357524 hypothetical protein from Streptomyces coelicolor (308 aa).; hypothetical protein	976075..976863	Mycobacterium tuberculosis H37Rv	885601
YP_177764.1	CDS	PPE13	NC_000962.2	976872	978203	R	Rv0878c, (MTCY31.06c), len: 443 aa. Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. P4261|YHS6_MYCTU (517 aa), FASTA scores: opt: 1044, E(): 0, (47.4% identity in 397 aa overlap); MTV014_3, MTCI65_2, MTCY98_24, MTCY3C7_23, MTCY48_17, MTV004_5, MTV004_3, etc.; PPE family protein	complement(976872..978203)	Mycobacterium tuberculosis H37Rv	885617
NP_215394.1	CDS	Rv0879c	NC_000962.2	978481	978756	R	Rv0879c, (MTCY31.07c), len: 91 aa. Possible conserved transmembrane protein, C-terminus highly similar to C-terminal part of MLCB57_14|O33059 conserved hypothetical protein from Mycobacterium leprae (91 aa), FASTA scores: E(): 1.2e-25, (76.9% identity in 91 aa overlap).; transmembrane protein	complement(978481..978756)	Mycobacterium tuberculosis H37Rv	885095
NP_215395.1	CDS	Rv0880	NC_000962.2	978934	979365	D	Rv0880, (MTCY31.08), len: 143 aa. Possible transcriptional regulator, MarR family, equivalent to MLCB57_15|O3306|NP_302411.1|NC_002677 putative MarR-family protein from Mycobacterium leprae (143 aa), FASTA scores: opt: 818, E(): 0, (89.5% identity in 143 aa overlap). Also similar to many others e.g. CAB93410.1|AL357524 putative marR-family protein from Streptomyces coelicolor (145 aa); NP_251757.1|NC_002516 probable transcriptional regulator from Pseudomonas aeruginosa (147 aa); etc. Also similar to Rv2327 from Mycobacterium tuberculosis (163 aa).; MarR family transcriptional regulator	978934..979365	Mycobacterium tuberculosis H37Rv	885205
NP_215396.1	CDS	Rv0881	NC_000962.2	979362	980228	D	Rv0881, (MTCY31.09), len: 288 aa. Possible rRNA methyltransferase (EC 2.1.1.-), highly similar to others and hypothetical proteins e.g. CAB76071.1|AL157953 putative rRNA methylase from Streptomyces coelicolor (272 aa); NP_421117.1|NC_002696 spoU rRNA methylase family protein from Caulobacter crescentus (268 aa); D90913_93|P74261 rRNA METHYLASE from Synechocystis sp. (274 aa), FASTA scores: E(): 1.1e-13, (26.3% identity in 278 aa overlap); P18644|TSNR_STRCN rRNA METHYLTRANSFERASE (EC 2.1.1.66) from Streptomyces cyaneus (Streptomyces curacoi) (269 aa), FASTA scores: E(): 3.7e-08, (23.9% identity in 268 aa overlap); etc. Equivalent to AAK45146.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 46 aa.; rRNA methyltransferase	979362..980228	Mycobacterium tuberculosis H37Rv	885121
NP_215397.1	CDS	Rv0882	NC_000962.2	980225	980509	D	Rv0882, (MTCY31.10), len: 94 aa. Probable transmembrane protein.; hypothetical protein	980225..980509	Mycobacterium tuberculosis H37Rv	885248
NP_215398.1	CDS	Rv0883c	NC_000962.2	980506	981267	R	Rv0883c, (MTCY31.11c), len: 253 aa. Conserved hypothetical protein, equivalent to O3306|MLCB57_16 CONSERVED HYPOTHETICAL PROTEI from Mycobacterium leprae (251 aa), FASTA scores: E(): 0, (79.4% identity in 253 aa overlap). Also highly similar to N_terminus of AL009204|SC9B10_22 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (352 aa), FASTA scores: E(): 6.1e-20, (35.0% identity in 246 aa overlap).; hypothetical protein	complement(980506..981267)	Mycobacterium tuberculosis H37Rv	885139
NP_215399.1	CDS	serC	NC_000962.2	981424	982554	R	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase	complement(981424..982554)	Mycobacterium tuberculosis H37Rv	885140
NP_215400.1	CDS	Rv0885	NC_000962.2	982762	983784	D	Rv0885, (MTCY31.13), len: 340 aa. Conserved hypothetical protein, equivalent to O33063|MLCB57_18 possible transmembrane protein from Mycobacterium leprae (341 aa), FASTA score: (83.9% identity in 341 aa overlap). Also similar except in C-terminus to T35630 probable membrane protein from Streptomyces coelicolor (312 aa).; hypothetical protein	982762..983784	Mycobacterium tuberculosis H37Rv	885285
NP_215401.1	CDS	fprB	NC_000962.2	983803	985530	D	Rv0886, (MTCY31.14), len: 525 aa. Probable fprB, ferredoxin/ferredoxin-NADP(+) reductase (NADPH:adrenodoxin oxidoreductase) (EC 1.18.1.2), equivalent to O3306|MLCB57_19 FERREDOXIN/FERREDOXIN--NADP REDUCTASE from Mycobacterium leprae (555 aa), FASTA scores: E(): 0, (76.6 identity in 560 aa overlap). Also highly similar or similar to others e.g. NP_294219.1|NC_001263 putative ferredoxin/ferredoxin--NADP reductase from Deinococcus radiodurans (479 aa) (N-terminus shorter); P22570|ADRO_HUMAN NADPH:adrenodoxin oxidoreductase from homo sapiens (497 aa), FASTA scores: opt: 624, E(): 3e-30, (39.7% identity in 484 aa overlap); P08165|ADRO_BOVIN NADPH:ADRENODOXIN OXIDOREDUCTASE from Bos taurus (492 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv3106, Rv3858c, etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.; NADPH:adrenodoxin oxidoreductase FprB	983803..985530	Mycobacterium tuberculosis H37Rv	885195
NP_215402.1	CDS	Rv0887c	NC_000962.2	985513	985971	R	Rv0887c, (MTCY31.15c), len: 152 aa. Conserved hypothetical protein, highly similar to others e.g. NP_436346.1|NC_003037 Hypothetical protein from Sinorhizobium meliloti (149 aa); AL132644|SCI8_26 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (194 aa), FASTA scores: opt: 220, E(): 1.5e-07, (33.6% identity in 131 aa overlap); etc. Also shows weak similarity with transposases and related proteins.; hypothetical protein	complement(985513..985971)	Mycobacterium tuberculosis H37Rv	885113
NP_215403.1	CDS	Rv0888	NC_000962.2	987233	988705	D	Rv0888, (MTCY31.16), len: 490 aa. Probable exported protein. Equivalent to AAK45157.1 from Mycobacterium tuberculosis strain CDC1551 (507 aa) but shorter 17 aa. Contains possible N-terminal signal sequence.; hypothetical protein	987233..988705	Mycobacterium tuberculosis H37Rv	885210
NP_215404.1	CDS	citA	NC_000962.2	988740	989861	R	forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; citrate synthase 2	complement(988740..989861)	Mycobacterium tuberculosis H37Rv	885466
NP_215405.1	CDS	Rv0890c	NC_000962.2	989948	992596	R	Rv0890c, (MTCY31.18c), len: 882 aa. Probable transcriptional regulatory protein, LuxR family, highly similar (but shorter 238 aa in N-terminus) to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also highly similar (generally in part) to others e.g. T50568 probable multi-domain regulatory protein from Streptomyces coelicolor (1334 aa); P10957|NARL_ECOLI nitrate/nitrite response regulator protein from Escherichia coli (216 aa), FASTA scores: opt: 193, E(): 6e-06, (37.4% identity in 99 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. MTCY02B10_22, MTV008_44, MTV036_21, and MTCY31_24. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature, and probable helix-turn helix motif from aa 836 to 857 (Score 1559, +4.50 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS.; LuxR family transcriptional regulator	complement(989948..992596)	Mycobacterium tuberculosis H37Rv	885227
NP_215406.1	CDS	Rv0891c	NC_000962.2	992598	993455	R	Rv0891c, (MTCY31.19c), len: 285 aa. Possible transcriptional regulator, highly similar in N-terminus to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also highly similar to several Mycobacterium tuberculosis putative transcriptional regulators e.g. Q1102|MTCY02B10_22 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (1159 aa), FASTA scores: opt: 702, E(): 8.3e-40, (50.6% identity in 247 aa overlap); MTV036_21; MTV008_44; MTCY02B10_23. Also shows similarity with several adenylate cyclases and hydrolases from other organisms.; transcriptional regulatory protein	complement(992598..993455)	Mycobacterium tuberculosis H37Rv	885493
NP_215407.1	CDS	Rv0892	NC_000962.2	993853	995340	D	Rv0892, (MTCY31.20), len: 495 aa. Probable monooxygenase (EC 1.14.-.-), highly similar to others e.g. NP_250787.1|NC_002516 probable flavin-binding monooxygenase from Pseudomonas aeruginosa (491 aa); CAB59668.1|AL132674 monooxygenase from Streptomyces coelicolor (519 aa); P12015|CYMO_ACIS cyclohexanone monooxygenase from Acinetobacter sp. (542 aa), FASTA scores: opt: 489, E(): 6.8e-26, (30.3% identity in 492 aa overlap); etc. Also highly similar to Rv0565c, Rv3854c, Rv3083, etc from Mycobacterium tuberculosis. Has hydrophobic stretch at N-terminus.; monooxygenase	993853..995340	Mycobacterium tuberculosis H37Rv	885225
NP_215408.1	CDS	Rv0893c	NC_000962.2	995318	996295	R	Rv0893c, (MTCY31.21c), len: 325 aa. Conserved hypothetical protein, belongs in family with P96823|Rv0146|MTCI5.20 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (310 aa), FASTA scores: opt: 784, E(): 0, (43.2% identity in 308 aa overlap); Rv0726c, Rv0731c, Rv3399, etc. Also shows some similarity with others e.g. SC9B5.10|T35930 hypothetical protein from Streptomyces coelicolor (303 aa); BSUB0008_141|Q45500 HYPOTHETICAL 34.8 kDa PROTEIN from Bacillus subtilis (304 aa), FASTA scores: E(): 0.00033, (26.8% identity in 168 aa overlap); etc.; hypothetical protein	complement(995318..996295)	Mycobacterium tuberculosis H37Rv	885477
NP_215409.1	CDS	Rv0894	NC_000962.2	996524	997705	D	Rv0894, (MTCY31.22), len: 393 aa. Possible regulatory protein, LuxR family, highly similar in part to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also similar to others e.g. CAB95788.1|AL359949 putative multi-domain regulatory protein from Streptomyces coelicolor (780 aa); NP_107293.1|NC_002678 transcriptional regulator from Mesorhizobium loti (903 aa); etc. Also similar to other regulatory proteins from Mycobacterium tuberculosis e.g. Rv2488c|MTV008_44 (1137 aa), FASTA score: (53.2% identity in 363 aa overlap); Rv1358|MTCY02B10_22 (1159 aa), FASTA score: (52.3% identity in 365 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; LuxR family transcriptional regulator	996524..997705	Mycobacterium tuberculosis H37Rv	885199
NP_215410.1	CDS	Rv0895	NC_000962.2	997782	999299	D	Rv0895, (MTCY31.23), len: 505 aa. Conserved hypothetical protein; member of family with: Rv3740c, Rv3734c, Rv1425, Rv1760, etc. Shows some similarity with NP_301898.1|NC_002677 conserved membrane protein from Mycobacterium leprae (491 aa).; hypothetical protein	997782..999299	Mycobacterium tuberculosis H37Rv	885481
NP_215411.1	CDS	gltA	NC_000962.2	999472	1000767	D	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase	999472..1000767	Mycobacterium tuberculosis H37Rv	885208
NP_215412.1	CDS	Rv0897c	NC_000962.2	1000808	1002415	R	Rv0897c, (MTCY31.25c), len: 535 aa. Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases from diverse organisms e.g. CAB94055.1|AL358672 putative oxidoreductase from Streptomyces coelicolor (540 aa); NP_147877.1|NC_000854 phytoene dehydrogenase from Aeropyrum pernix (549 aa); Q01671|CRTD_RHOSH methoxyneurosporene dehydrogenase from Rhodobacter sphaeroides (495 aa), FASTA scores: opt: 139, E(): 2.6e-06, (23.8% identity in 538 aa overlap); etc. Also similar to Rv1432, Rv2997, and Rv3829c from Mycobacterium tuberculosis.; oxidoreductase	complement(1000808..1002415)	Mycobacterium tuberculosis H37Rv	885641
NP_215413.1	CDS	Rv0898c	NC_000962.2	1002441	1002704	R	Rv0898c, (MTCY31.26c), len: 87 aa. Conserved hypothetical protein, highly similar to CAC01589.1|AL391041 hypothetical protein from Streptomyces coelicolor (87 aa). Also shows some similarity to Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77 aa), FASTA score: (28.8% identity in 73 aa overlap).; hypothetical protein	complement(1002441..1002704)	Mycobacterium tuberculosis H37Rv	885206
NP_215414.1	CDS	ompA	NC_000962.2	1002812	1003792	D	Rv0899, (MTCY31.27), len: 326 aa. ompA, outer membrane protein A (see citation below). C-terminal region similar to C-terminus of many members of the OMPA family of outer membrane proteins, e.g. NP_458280.1|NC_003198 putative outer membrane protein from Salmonella enterica subsp. enterica serovar Typhi (220); NP_418008.1|NC_000913 putative outer membrane protein from Escherichia coli strain K12 (219 aa), FASTA scores: opt: 296, E(): 2.2e-11, (45.3% identity in 117 aa overlap); NP_231844.1|NC_002505 outer membrane protein OmpA from Vibrio cholerae (321 aa); Q05146|OMPA_BORAV OUTER MEMBRANE PROTEIN A PRECURSOR from Bordetella avium (194 aa); etc. A signal peptide sequence probably exists at the N-terminus. Contains PS00044 Bacterial regulatory proteins, lysR family signature. BELONGS TO THE OMPA FAMILY.; outer membrane protein A OMPA	1002812..1003792	Mycobacterium tuberculosis H37Rv	885286
NP_215415.1	CDS	Rv0900	NC_000962.2	1003805	1003957	D	Rv0900, (MTCY31.28), len: 50 aa. Possible membrane protein, with hydrophobic domain from aa 4-26.; hypothetical protein	1003805..1003957	Mycobacterium tuberculosis H37Rv	885179
NP_215416.1	CDS	Rv0901	NC_000962.2	1003957	1004484	D	Rv0901, (MTCY31.29), len: 175 aa. Possible conserved exported or membrane protein, with hydrophobic N-terminus at aa 7-25. Shows some similarity in C-terminus to O33070|Z99494|MLCB57.59 HYPOTHETICAL PROTEIN from Mycobacterium leprae (113 aa), FASTA scores: opt: 204, E(): 3.2e-12, (44.9% identity in 78 aa overlap).; hypothetical protein	1003957..1004484	Mycobacterium tuberculosis H37Rv	885203
NP_215417.1	CDS	prrB	NC_000962.2	1004501	1005841	R	Rv0902c, (MTCY31.30c), len: 446 aa. prrB, two-component sensor histidine kinase (EC 2.7.3.-) (see citations below), transmembrane protein, equivalent to MLCB57_26|NP_302403.1|NC_002677 sensor histidine kinase from Mycobacterium leprae (446 aa); and similar at C-termini to NP_301251.1|NC_002677 putative two-component system sensor kinase from Mycobacterium leprae (519 aa). C-terminus also similar to the C-termini of many sensor-like histidine kinase proteins e.g. P08336|CPXA_ECOLI|ECFB|SSD|EUP|B3911|Z5456|ECS4837 sensor protein from Escherichia coli strain K12 (457 aa), FASTA scores: opt: 364, E(): 1.7e-15, (27.1% identity in 398 aa overlap); CAB89748.1|AL354616 putative two-component histidine kinase from Streptomyces coelicolor (483 aa); CAB82845.1|AJ277081 putative histidine kinase from Amycolatopsis mediterranei (472 aa); etc. Also similar in part to Mycobacterium tuberculosis proteins Rv3764c (475 aa); and Rv0982 (504 aa). Thought to be induced at phagocytosis (see Graham & Clark-Curtiss 1999).; two component sensor histidine kinase PRRB	complement(1004501..1005841)	Mycobacterium tuberculosis H37Rv	885647
NP_215418.1	CDS	prrA	NC_000962.2	1005852	1006562	R	Rv0903c, (MTCY31.31c), len: 236 aa. prrA, two-component response regulator (see citations below), equivalent to Z99494|MLCB57_27|NP_302402.1|NC_002677 two-component response regulator from Mycobacterium leprae (233 aa), FASTA scores: opt: 1414, E(): 0, (95.7% identity in 233 aa overlap); and similar to T45446 probable two-component response regulator from Mycobacterium leprae (253 aa). Also similar to many sensor-like histidine kinase proteins e.g. CAB88489.1|AL353816 putative two-component systen response regulator from Streptomyces coelicolor (248 aa); AAG36759.1|AF119221_1 |AF119221 response regulator from Corynebacterium glutamicum (232 aa); Q02540|COPR_PSESM transcriptional activator protein COPR from Pseudomonas syringae (pv. tomato) (227 aa), FASTA scores: opt: 600, E(): 0, (44.4% identity in 225 aa overlap); etc. Also similar to Rv0981 from Mycobacterium tuberculosis (230 aa), Rv3765c (234 aa), phoP (247 aa), etc. Thought to be induced at phagocytosis (see Graham & Clark-Curtiss 1999).; two component response transcriptional regulatory protein PRRA	complement(1005852..1006562)	Mycobacterium tuberculosis H37Rv	885209
NP_215419.1	CDS	accD3	NC_000962.2	1006693	1008180	R	Rv0904c, (MTCY31.32c, MT0927), len: 495 aa. Putative accD3, acetyl-CoA carboxylase carboxyl transferase, beta subunit (carboxyltransferase subunit of acetyl-CoA carboxylase) (EC 6.4.1.2), highly similar in part to AAA63045.1|U15184 zinc finger protein from Mycobacterium leprae (201 aa). Also highly similar to others e.g. CAC42827.1|Y17592 putative carboxyltransferase subunit of acetyl-CoA carboxylase from Corynebacterium glutamicum (491 aa); CAB86110.1|AL163003 putative acetyl CoA carboxylase (alpha and beta subunits) from Streptomyces coelicolor (458 aa); Q54776|ACCD_SYNP7 ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA from Synechococcus sp. (305 aa); P12217|ACCD_MARPO ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA from Marchantia polymorpha (316 aa), FASTA scores: opt: 519, E():1.6e-24, (40.2% identity in 219 aa overlap); etc. Also similar to Rv3280, Rv2502c, etc from Mycobacterium tuberculosis. BELONGS TO THE ACCD/PCCB FAMILY.; putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	complement(1006693..1008180)	Mycobacterium tuberculosis H37Rv	885279
NP_215420.1	CDS	echA6	NC_000962.2	1008207	1008938	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	1008207..1008938	Mycobacterium tuberculosis H37Rv	885825
NP_215421.1	CDS	Rv0906	NC_000962.2	1008944	1010062	D	Rv0906, (MTCY31.34), len: 372 aa. Conserved hypothetical protein, highly similar to others e.g. SC6A5.25|AL049485|T35416 hypothetical protein from Streptomyces coelicolor (370 aa), FASTA scores: opt: 1125, E(): 0, (51.3% identity in 335 aa overlap); NP_242955.1|NC_002570|BH2089 conserved protein from Bacillus halodurans (370 aa); etc. Also shows some similarity to C-terminus of Q48412|ROMA_KLEPN Q48412 outer membrane protein roma (fragment) from Klebsiella pneumoniae (132 aa), FASTA scores: opt: 319, E(): 8.5e-14, (46.2% identity in 104 aa overlap); NP_105215.1|NC_002678 hypothetical protein which contains similarity to outer membrane protein romA from Enterobacter cloacae (350 aa); etc.; hypothetical protein	1008944..1010062	Mycobacterium tuberculosis H37Rv	885150
NP_215422.1	CDS	Rv0907	NC_000962.2	1010136	1011734	D	Rv0907, (MTCY21C12.01), len: 532 aa. Conserved hypothetical protein, possibly involved in cell wall biosynthesis: similar to many beta-lactamases, penicillin-binding proteins and hypothetical proteins e.g. NP_298910.1|NC_002488 beta-lactamase from Xylella fastidiosa (455 aa); Q06317|PBP4_NOCLA PENICILLIN-BINDING PROTEIN 4 (PBP-4) (381 aa), FASTA scores: opt: 299, E(): 8.8e-05, (28.7% identity in 401 aa overlap); etc. N-terminus highly similar to AAA63047.1|U15184 hypothetical protein from Mycobacterium leprae (58 aa). Related to other putative esterases and penicillin binding proteins in Mycobacterium tuberculosis e.g. Rv1730c|MTCY04C12.15c (517 aa).; hypothetical protein	1010136..1011734	Mycobacterium tuberculosis H37Rv	885146
NP_215423.1	CDS	ctpE	NC_000962.2	1011731	1014124	D	Rv0908, (MTCY21C12.02), len: 797 aa. Probable ctpE, metal cation-transporting ATPase P-type, transmembrane protein, E1-E2 family, highly similar to many e.g. AB93406.1|AL357524 putative integral membrane ATPase from Streptomyces coelicolor (802 aa); NP_346063.1|NC_003028 cation-transporting ATPase (E1-E2 family) from Streptococcus pneumoniae (778 aa); P37278|ATCL_SYNP7|PACL cation-transporting atpase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (926 aa), FASTA scores: opt: 257, E(): 4.8e-33, (27.7% identity in 905 aa overlap); etc. Contains E1-E2 ATPases phosphorylation site (PS00154). BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES).; metal cation transporter ATPase P-type CtpE	1011731..1014124	Mycobacterium tuberculosis H37Rv	885657
NP_215424.1	CDS	Rv0909	NC_000962.2	1014681	1014860	D	Rv0909, (MTCY21C12.03), len: 59 aa. Conserved hypothetical protein, equivalent to NP_302399.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (56 aa). Also some similarity with AL022268|SC4H2_10c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (97 aa), FASTA scores: opt: 106, E(): 0.13, (43.2% identity in 37 aa overlap).; hypothetical protein	1014681..1014860	Mycobacterium tuberculosis H37Rv	885197
NP_215425.1	CDS	Rv0910	NC_000962.2	1014866	1015300	D	Rv0910, (MTCY21C12.04), len: 144 aa. Conserved hypothetical protein, equivalent to NP_302398.1|NC_002677 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (181 aa), FASTA scores: opt: 820, E(): 0, (83.9% identity in 143 aa overlap). Also similar to Rv1546|MTCY48.19c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (143 aa).; hypothetical protein	1014866..1015300	Mycobacterium tuberculosis H37Rv	885137
NP_215426.1	CDS	Rv0911	NC_000962.2	1015398	1016171	D	Rv0911, (MTCY21C12.05), len: 257 aa. Conserved hypothetical protein, showing similarity with hydroxylases and hypothetical proteins e.g. T35325 probable hydroxylase from Streptomyces coelicolor (265 aa); Q54242 hypothetical protein from Streptomyces, FASTA scores: opt: 372, E(): 8.8e-18, (32.0% identity in 256 aa overlap); AAD04716.1|U77891 doxorubicin biosynthesis enzyme DnrV from Streptomyces peucetius (275 aa); AAA63051.1|U15184 hypothetical protein from Mycobacterium leprae (94 aa); etc. Also similar to Rv0577 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (261 aa).; hypothetical protein	1015398..1016171	Mycobacterium tuberculosis H37Rv	885093
NP_215427.1	CDS	Rv0912	NC_000962.2	1016236	1016685	D	Rv0912, (MTCY21C12.06), len: 149 aa. Probable conserved transmembrane protein, equivalent to Q50121|NP_302397.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (144 aa), FASTA scores: opt: 677, E(): 6.9e-38, (69.5% identity in 141 aa overlap).; transmembrane protein	1016236..1016685	Mycobacterium tuberculosis H37Rv	885103
NP_215428.1	CDS	Rv0913c	NC_000962.2	1017217	1018725	R	Rv0913c, (MTCY21C12.07c), len: 501 aa. Possible dioxygenase (EC 1.-.-.-), showing similarity with others e.g. AAK38744.1|AY029525 carotenoid 9,10-9',10' cleavage dioxygenase from Phaseolus vulgaris (543 aa); CAB56138.1|AL117669 putative dioxygenase from Streptomyces coelicolor (503 aa); AAK06796.1|AF324838_15|AF324838 putative dioxygenase SimC5 from Streptomyces antibioticus (456 aa); Q53353|S65040 LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE (EC 1.13.11.43) from Pseudomonas paucimobilis (485 aa), FASTA scores: opt: 310, E(): 3.4e-20, (28.9% identity in 495 aa overlap); etc. Also some similarity with Rv0654|MTCI376.22 PROBABLE DIOXYGENASE from Mycobacterium tuberculosis (501 aa).; dioxygenase	complement(1017217..1018725)	Mycobacterium tuberculosis H37Rv	885042
NP_215429.1	CDS	Rv0914c	NC_000962.2	1018727	1019965	R	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase	complement(1018727..1019965)	Mycobacterium tuberculosis H37Rv	885046
YP_177765.1	CDS	PPE14	NC_000962.2	1020058	1021329	R	Rv0915c, (MTCY21C12.09c), len: 423 aa. PPE14 (alternate gene name: MTB41). Member of the Mycobacterium tuberculosis PPE family (see citation below), highly similar to many e.g. Rv1807 from Mycobacterium tuberculosis (403 aa), FASTA scores: opt: 966, E(): 4.4e-30, (45.7% identity in 392 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.; MTB41; PPE family protein	complement(1020058..1021329)	Mycobacterium tuberculosis H37Rv	885069
YP_177766.1	CDS	PE7	NC_000962.2	1021344	1021643	R	Rv0916c, (MTCY21C12.10c), len: 99 aa. PE7 (alternate gene name: MTB10). Member of the Mycobacterium tuberculosis PE family (see citations below), similar to many e.g. Rv1788 from Mycobacterium tuberculosis (99 aa), FASTA scores: opt: 321, E(): 1.3e-11, (53.5% identity in 99 aa overlap); etc.; MTB10; PE family protein	complement(1021344..1021643)	Mycobacterium tuberculosis H37Rv	885167
NP_215432.1	CDS	betP	NC_000962.2	1022087	1023868	D	Rv0917, (MTCY21C12.11), len: 593 aa. Possible betP, glycine betaine transporter, integral membrane protein, highly similar to many transporters, mainly glycine betaine transporters, e.g. P54582|BETP_CORGL glycine betaine transporter from Corynebacterium glutamicum (Brevibacterium flavum) (595 aa), FASTA scores: opt: 1367, E(): 0, (42.7% identity in 504 aa overlap); T35264 probable BCCT family transporter from Streptomyces coelicolor (578 aa); NP_243511.1|NC_002570 glycine betaine transporter from Bacillus halodurans (504 aa); NP_439848.1|NC_000907 high-affinity choline transport protein (betT) from Haemophilus influenzae (669 aa); etc. SEEMS TO BELONG TO THE BCCT (TC 2.33) FAMILY OF TRANSPORTERS.; glycine betaine transport integral membrane protein BetP	1022087..1023868	Mycobacterium tuberculosis H37Rv	885172
NP_215433.1	CDS	Rv0918	NC_000962.2	1024211	1024687	D	Rv0918, (MTCY21C12.12), len: 158 aa. Conserved hypothetical protein, similar in part to Q50116 hypothetical protein from Mycobacterium leprae (44 aa), FASTA scores: opt: 132, E(): 0.0055, (65.6% identity in 32 aa overlap). Also some similarity in C-terminus with other hypothetical proteins e.g. NP_289961.1|NC_002655 hypothetical protein from Escherichia coli strain O157:H7 (94 aa); etc.; hypothetical protein	1024211..1024687	Mycobacterium tuberculosis H37Rv	885198
NP_215434.1	CDS	Rv0919	NC_000962.2	1024684	1025184	D	Rv0919, (MTCY21C12.13), len: 166 aa. Conserved hypothetical protein, some similarity to Q50115 hypothetical protein from Mycobacterium leprae (90 aa), FASTA scores: opt: 243, E(): 5.3e-11, (56.5% identity in 85 aa overlap).; hypothetical protein	1024684..1025184	Mycobacterium tuberculosis H37Rv	885221
NP_215435.1	CDS	Rv0920c	NC_000962.2	1025497	1026816	R	Rv0920c, (MTCY21C12.14c), len: 439 aa. Probable transposase for IS1554, highly similar to others e.g. MTCY441.35|Q45111 transposase from Mycobacterium tuberculosis (419 aa), FASTA scores: opt: 1113, E(): 0, (43.9% identity in 378 aa overlap); etc. Contains transposases mutator family signature (PS01007).; transposase	complement(1025497..1026816)	Mycobacterium tuberculosis H37Rv	885549
NP_215436.1	CDS	Rv0921	NC_000962.2	1027104	1027685	D	Rv0921, (MTCY21C12.15), len: 193 aa. Possible resolvase for IS1535, highly similar to many bacterial resolvases e.g. MTCY274.17c|YX1C_MYCTU Q10831 from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 537, E(): 5.7e-29, (51.8% identity in 166 aa overlap). Presents an helix turn helix motif.; resolvase	1027104..1027685	Mycobacterium tuberculosis H37Rv	885557
NP_215437.1	CDS	Rv0922	NC_000962.2	1027685	1029337	D	Rv0922, (MTCY21C12.16), len: 550 aa. Possible transposase for IS1535, similar to many e.g. YX16_MYCTU|Q10809|MTCY274.16c from Mycobacterium tuberculosis (460 aa), FASTA scores: opt 939, E(): 0, (40.6% identity in 465 aa overlap); etc.; transposase	1027685..1029337	Mycobacterium tuberculosis H37Rv	885564
NP_215438.1	CDS	Rv0923c	NC_000962.2	1029513	1030577	R	Rv0923c, (MTCY21C12.17c), len: 354 aa. Conserved hypothetical protein, showing similarity with C-terminal part of AF034138|AF034138_7|yjoB HYPOTHETICAL PROTEIN from Bacillus subtilis (200 aa), FASTA scores: opt: 193, E(): 4.2e-05, (32.3% identity in 167 aa overlap).; hypothetical protein	complement(1029513..1030577)	Mycobacterium tuberculosis H37Rv	885568
YP_177767.1	CDS	mntH	NC_000962.2	1030578	1031864	R	Rv0924c, (MTCY21C12.18c), len: 428 aa. mntH (alternative gene name: Nramp, Mramp), H+-dependent divalent cation-transport integral membrane protein (see citations below), equivalent to O69443|MNTH_MYCBO PROBABLE MANGANESE TRANSPORT PROTEIN MNTH (BRAMP) from Mycobacterium bovis (415 aa); and NP_302396.1|NC_002677 probable manganese transport protein from Mycobacterium leprae (426 aa). Also similar (but longer 51 aa in N-terminus) to AAA63075.1|U15184 SMF2 protein from Mycobacterium leprae (377 aa), FASTA scores: opt: 1780, E(): 0, (74.5% identity in 376 aa overlap). Also similar to many orthologues of the eukaryotic Nramp (natural resistance-associated macrophage protein), also known as mntH, e.g. NP_456951.1|NC_003198 manganese transport protein MntH from Salmonella enterica subsp. enterica serovar Typhi (413 aa); etc. BELONGS TO THE NRAMP FAMILY.; Nramp; Mramp; manganese transport protein MntH	complement(1030578..1031864)	Mycobacterium tuberculosis H37Rv	885569
NP_215440.1	CDS	Rv0925c	NC_000962.2	1031896	1032633	R	Rv0925c, (MTCY21C12.19c), len: 245 aa. Conserved hypothetical protein, similar to AL132991|SCF55_19 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (197 aa), FASTA scores: opt: 459, E(): 1.2e-23, (39.3% identity in 201 aa overlap).; hypothetical protein	complement(1031896..1032633)	Mycobacterium tuberculosis H37Rv	885570
NP_215441.1	CDS	Rv0926c	NC_000962.2	1032710	1033786	R	Rv0926c, (MTCY21C12.20c), len: 358 aa. Conserved hypothetical protein, similar to Rv1059 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (354 aa). Also shows some similarity to AF170923|AF170923_3 dihydrodipicolinate reductase from Mastigocladus laminosus (278 aa), FASTA scores: opt: 170, E(): 0.00088, (25.7% identity in 276 aa overlap).; hypothetical protein	complement(1032710..1033786)	Mycobacterium tuberculosis H37Rv	885387
NP_215442.1	CDS	Rv0927c	NC_000962.2	1033840	1034631	R	Rv0927c, (MTCY21C12.21c), len: 263 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases, notably 7-alpha-hydroxysteroid dehydrogenases and glucose 1-dehydrogenases e.g. P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 551, E(): 1e-26, (39.5% identity in 248 aa overlap); NP_252778.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (253 aa); AAC44307.1|U59433 3-ketoacyl-acyl carrier protein reductase from Bacillus subtilis (246 aa); etc. Also similar to other dehydrogenases from Mycobacterium tuberculosis e.g. MTCY09F9.36, E():1.4e-18; MTCY369.14, E():8e-17; MTCY02B10.14, E():2.5e-14; MTCY09F9.23c, E():1.5e-13; MTCY03C7.07, E():1.9e-13. Contains PS00061 Short-chain dehydrogenases/reductases family signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short chain dehydrogenase	complement(1033840..1034631)	Mycobacterium tuberculosis H37Rv	885571
YP_177768.1	CDS	pstS3	NC_000962.2	1034903	1036015	D	Rv0928, (MTCY21C12.22), len: 370 aa. pstS3 (previously known as phoS2), phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below), highly similar to others from Mycobacterium leprae e.g. Q50099|PSTS3|PHOS1 phosphate-binding protein 3 precursor (328 aa), FASTA scores: opt: 1772, E(): 0, (79.6% identity in 328 aa overlap); and highly similar to others e.g. AAF74819.1|AF137360_1|AF137360 periplasmic phosphate permease from Mycobacterium avium (369 aa). Also highly similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (370 aa); and Rv0934|pstS1 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN (374 aa) from Mycobacterium tuberculosis (Mycobacterium tuberculosis seems to have three PstS-like proteins, others being Rv0932c and Rv0934c). Contains lipoprotein signature (PS00013) at N-terminus. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS.; phoS2; periplasmic phosphate-binding lipoprotein PSTS3 (PBP-3) (PSTS3) (PHOS1)	1034903..1036015	Mycobacterium tuberculosis H37Rv	885366
NP_215444.1	CDS	pstC2	NC_000962.2	1036028	1037002	D	Rv0929, (MTCY21C12.23), len: 324 aa. pstC2, phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_302394.1|NC_002677 membrane-bound component of phosphate transport from Mycobacterium leprae (319 aa); CAB88474.1|AL353816 phosphate ABC transport system permease protein from Streptomyces coelicolor (336 aa); NP_290359.1| NC_002655 high-affinity phosphate-specific transport system (cytoplasmic membrane component) from Escherichia coli strain O157:H7 (319 aa); etc. Also similar to Rv935|MTCY08D9.04c|PSTC1 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (338 aa). Contains binding-protein-dependent transport systems inner membrane component signature (PS00402).; phosphate ABC transporter transmembrane protein	1036028..1037002	Mycobacterium tuberculosis H37Rv	885585
NP_215445.2	CDS	pstA1	NC_000962.2	1036999	1037925	D	Rv0930, (MTCY21C12.24), len: 308 aa. Probable pstA1, phosphate-transport integral membrane ABC transporter (see citation below), highly similar to others e.g. NP_302393.1|NC_002677 membrane-bound component of phosphate transport from Mycobacterium leprae (304 aa); CAB88473.1|AL353816 phosphate ABC transport system permease protein from Streptomyces coelicolor (354 aa) (N-terminus longer); NP_312689.1|NC_002695 phosphate transport system permease protein PstA from Escherichia coli strain O157:H7 (296 aa); etc. Also similar to Rv0936|MTCY08D9.03c|PSTA2 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (301 aa).; phosphate ABC transporter transmembrane protein	1036999..1037925	Mycobacterium tuberculosis H37Rv	885589
NP_215446.1	CDS	pknD	NC_000962.2	1037920	1039914	R	Rv0931c, (MTCY08D9.08), len: 664 aa. pknD (alternate gene name: mbk), transmembrane serine/threonine protein kinase (EC 2.7.1.-) (see citations below), equivalent to CAB62227.1|AJ250200 putative serine/threonine protein kinase from Mycobacterium bovis BCG (291 aa); and highly similar in N-terminus to P54744|PKNB_MYCLE probable serine/threonine-specific protein kinase (EC 2.7.1.-) from Mycobacterium leprae (622 aa). Also highly similar to others, particularly in N-terminal half e.g. NP_243370.1|NC_002570 serine/threonine protein kinase from Bacillus halodurans (664 aa); NP_268044.1|NC_002662 serine/threonine protein kinase from Lactococcus lactis (627 aa); etc. Also highly similar to other serine/threonine protein kinases from Mycobacterium tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398, E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa); pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's kinase subdomain. Contains two transmembrane segments, which flank a highly repetitive region, suggesting a receptor-like anchoring. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation on a serine residue. Appears to be co-transcribed with Rv0932c|pstS2.; mbk; transmembrane serine/threonine-protein kinase D PKND (protein kinase D) (STPK D)	complement(1037920..1039914)	Mycobacterium tuberculosis H37Rv	885607
YP_177769.1	CDS	pstS2	NC_000962.2	1039936	1041048	R	Rv0932c, (MTCY08D9.07), len: 370 aa. pstS2, phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below), highly similar to AAF74819.1|AF137360_1|AF137360 periplasmic phosphate permease from Mycobacterium avium (369 aa); Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (370 aa), FASTA scores: opt: 1601, E(): 0, (64.5% identity in 372 aa overlap); and Rv0934|MTCY08D9.05c|pstS1 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (374 aa) (Mycobacterium tuberculosis seems to have three PstS-like proteins, others being Rv0928 and Rv0934c). Also highly similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B PRECURSOR from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 460, E(): 2.7e-20, (31.2% identity in 375 aa overlap). Contains prokaryotic membrane lipoprotein lipid attachment site (PS00013) at N-terminus so the leader peptide of 22 aa is probably removed. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS. Appears to be co-transcribed with Rv0931c|pknD|mbk.; periplasmic phosphate-binding lipoprotein PSTS2 (PBP-2) (PSTS2)	complement(1039936..1041048)	Mycobacterium tuberculosis H37Rv	885613
NP_215448.1	CDS	pstB	NC_000962.2	1041264	1042094	D	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate ABC transporter ATP-binding protein	1041264..1042094	Mycobacterium tuberculosis H37Rv	885653
YP_177770.1	CDS	pstS1	NC_000962.2	1042115	1043239	D	Rv0934, (MTCY08D9.05c), len: 374 aa. pstS1 (previously known as phoS1 or phoS), phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below), highly similar to Rv0932c|MTCY08D9.07|pstS2 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (370 aa), FASTA scores: opt: 460, E(): 5.9e-19, (31.2% identity in 375 aa overlap); and Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 435, E():1.1e-17, (30.0% identity in 380 aa overlap) (Mycobacterium tuberculosis seems to have three PstS-like proteins, others being Rv0932c and Rv0928c). Also highly similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B PRECURSOR from Mycobacterium tuberculosis (374 aa), FASTA scores: opt: 2459, E(): 0, (100% identity in 374 aa overlap). Contains a prokaryotic membrane lipoprotein lipid attachment site (PS00013) at the N-terminus so the 23 aa leader peptide sequence is probably removed. BELONGS TO FAMILY OF PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN TRANSPORTERS.; phoS1; phoS; periplasmic phosphate-binding lipoprotein PSTS1 (PBP-1) (PSTS1)	1042115..1043239	Mycobacterium tuberculosis H37Rv	885724
YP_177771.1	CDS	pstC1	NC_000962.2	1043299	1044315	D	Rv0935, (MTCY08D9.04c), len: 338 aa. pstC1, phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_104768.1|NC_002678|pstC phosphate ABC transporter permease protein from Mesorhizobium loti (327 aa); NP_245372.1|NC_002663|PstC PstC protein from Pasteurella multocida (320 aa); P45191|PSTC_HAEIN PHOSPHATE TRANSPORT SYSTEM PERMEASE from Haemophilus influenza (315 aa), FASTA scores: opt: 667, E(): 0, (36.2% identity in 309 aa overlap); etc. Also similar to Rv0929|MTCY21C12.23|PSTC2 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (324 aa), FASTA scores: opt: 487, E(): 4.1e-21, (32.3% identity in 303 aa overlap); and shows slight similarity to MTCY08D9.03c|PSTA2|Rv0936 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (301 aa). Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402).; phosphate ABC transporter transmembrane protein	1043299..1044315	Mycobacterium tuberculosis H37Rv	885644
NP_215451.1	CDS	pstA2	NC_000962.2	1044317	1045222	D	Rv0936, (MTCY08D9.03c), len: 301 aa. pstA2, phosphate-transport integral membrane ABC transporter (see citations below), highly similar to others e.g. NP_442269.1|NC_000911|PstA phosphate transport system permease protein from Synechocystis sp. strain PCC 6803 (287 aa); NP_232473.1|NC_002506 phosphate ABC transporter permease protein from Vibrio cholerae (289 aa); P07654|PSTA_ECOLI PHOSPHATE TRANSPORT SYSTEM PERMEASE from Escherichia coli (296 aa), FASTA scores: opt: 464, E(): 6.7e-24, (30.5% identity in 282 aa overlap); etc. Also similar to O86345|MTCY21C12.24|PSTA1|Rv0930 PROBABLE TRANSMEMBRANE ABC TRANSPORTER COMPONENT OF PHOSPHATE UPTAKE SYSTEM from Mycobacterium tuberculosis (304 aa), FASTA scores: opt: 369, E(): 6.1e-15, (32.7% identity in 248 aa overlap). Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402).; phosphate ABC transporter transmembrane protein	1044317..1045222	Mycobacterium tuberculosis H37Rv	885756
NP_215452.1	CDS	Rv0937c	NC_000962.2	1045199	1046020	R	Rv0937c, (MTCY08D9.02), len: 273 aa. Conserved hypothetical protein, highly similar to others e.g. SC6G9.24c|T35620|AL079356 hypothetical protein from Streptomyces coelicolor (365 aa), FASTA scores: opt: 648, E(): 0, (36.5% identity in 274 aa overlap); Z99110|BSUB0007_223|NP_389224.1|NC_000964 hypothetical proteins from Bacillus subtilis (311 aa), FASTA scores: opt: 623, E(): 1.1e-31, (33.9% identity in 274 aa overlap); O28548|AE000984|AF1726|NP_070554.1|NC_000917 conserved hypothetical protein from Archaeoglobus fulgidus (286 aa), FASTA scores: opt: 583, E(): 0, (36.6% identity in 262 aa overlap); etc.; hypothetical protein	complement(1045199..1046020)	Mycobacterium tuberculosis H37Rv	885050
NP_215453.1	CDS	Rv0938	NC_000962.2	1046136	1048415	D	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; ATP-dependent DNA ligase	1046136..1048415	Mycobacterium tuberculosis H37Rv	885561
NP_215454.1	CDS	Rv0939	NC_000962.2	1048412	1050346	D	Rv0939, (MTCY10D7.35c), len: 644 aa. Possible bifunctional enzyme, including 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase activity (EC 5.3.3.-), and cyclase/dehydrase activity (EC undetermined). N-terminal part similar to many isomerases e.g. NP_343861.1|NC_002754 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1) from Sulfolobus solfataricus (318 aa); NP_068932.1|NC_000917 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1) from Archaeoglobus fulgidus (324 aa), FASTA scores: opt: 400, E(): 5.8e-15, (33.9% identity in 289 aa overlap); etc. And C-terminal part highly similar to many cyclases/dehydrases e.g. AAK61721.1|AY033994 cyclase-like protein from Streptomyces aureofaciens (305 aa); CAC44204.1|AL593842 cyclase from Streptomyces coelicolor (297 aa), FASTA scores: opt: 375, E(): 2.7e-26, (35.6% identity in 284 aa overlap); NP_343860.1|NC_002754 putative Cyclase/dehydrase from Sulfolobus solfataricus (308 aa); etc. Also similar to Rv2993c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis.; bifunctional 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase/cyclase/dehydrase	1048412..1050346	Mycobacterium tuberculosis H37Rv	885560
NP_215455.1	CDS	Rv0940c	NC_000962.2	1050593	1051459	R	Rv0940c, (MTCY10D7.34), len: 288 aa. Possible oxidoreductase (EC 1.-.-.-), similar to hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); AAG52987.1|AF040570|Rif17 putative alkanal monooxygenase from Amycolatopsis mediterranei (356 aa); etc. Also similar to putative oxidoreductases from Mycobacterium tuberculosis such as Rv0953c|P71557|YT21_MYCTU (282 aa), FASTA scores: opt: 311, E(): 3.7e-08, (31.0% identity in 248 aa overlap), Rv3079c (275 aa), Rv0791c (347 aa), etc.; oxidoreductase	complement(1050593..1051459)	Mycobacterium tuberculosis H37Rv	885412
NP_215456.1	CDS	Rv0941c	NC_000962.2	1051544	1052317	R	Rv0941c, (MTCY10D7.33), len: 257 aa. Conserved hypothetical protein, showing some similarity with parts of several hypothetical proteins from Streptomyces coelicolor e.g. AL035161|SC9C7_20 (860 aa), FASTA scores: opt: 197, E(): 2.6e-05, (34.2% identity in 114 aa overlap).; hypothetical protein	complement(1051544..1052317)	Mycobacterium tuberculosis H37Rv	885914
NP_215457.1	CDS	Rv0942	NC_000962.2	1052360	1052638	D	Rv0942, (MTCY10D7.32c), len: 92 aa. Hypothetical unknown protein.; hypothetical protein	1052360..1052638	Mycobacterium tuberculosis H37Rv	885913
NP_215458.1	CDS	Rv0943c	NC_000962.2	1052696	1053736	R	Rv0943c, (MTCY10D7.31), len: 346 aa. Possible monooxygenase (EC 1.-.-.-), similar in part to others e.g. NP_250229.1|NC_002516 probable flavin-containing monooxygenase from Pseudomonas aeruginosa (527 aa); AAC36351.1|AF090329 cyclohexanone monooxygenase homolog from Pseudomonas fluorescens (437 aa); CAB59668.1|AL132674 monooxygenase from Streptomyces coelicolor (519 aa); etc. Also similar to putative monooxygenases from Mycobacterium tuberculosis e.g. Rv1393c|P71662|CY21B4.10C (492 aa). FASTA scores: opt: 129, E(): 8.5e-21, (27.5% identity in 236 aa overlap); Rv0892 (495 aa); Rv3049c (524 aa); etc.; monooxygenase	complement(1052696..1053736)	Mycobacterium tuberculosis H37Rv	885889
NP_215459.1	CDS	Rv0944	NC_000962.2	1053765	1054241	D	Rv0944, (MTCY10D7.30c), len: 158 aa. Possible formamidopyrimidine-DNA glycosylase (EC 3.2.2.23), similar to C-terminus of formamidopyrimidine-DNA glycosylases e.g. CAB63194.1|AL133469 putative formamidopyrimidine-DNA glycosylase from Streptomyces coelicolor (287 aa); FPG_LACLA|NP_266509.1|NC_002662 formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) from Lactococcus lactis subsp. lactis (273 aa), FASTA scores: opt: 246, E(): 2.4e-09, (28.9% identity in 142 aa overlap); O50606|FPG_THETH|MUTM|FPG FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Thermus thermophilus (267 aa); etc. Also similar to C-termini of endonucleases or DNA glycosylases of Mycobacterium tuberculosis e.g. Rv3297, Rv2464c, Rv2924c. MAY BE BELONG TO THE FPG FAMILY.; formamidopyrimidine-DNA glycosylase	1053765..1054241	Mycobacterium tuberculosis H37Rv	885888
NP_215460.1	CDS	Rv0945	NC_000962.2	1054247	1055008	D	Rv0945, (MTCY10D7.29c), len: 253 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases e.g. NP_346338.1|NC_003028 oxidoreductase (short chain dehydrogenase/reductase family) from Streptococcus pneumoniae (253 aa); AAB70845.1|AF019986|PksB from Dictyostelium discoideum (260 aa); AAF86624.1|U87786 clavaldehyde dehydrogenase from Streptomyces clavuligerus (247 aa); P37440|UCPA_ECOLI oxidoreductase from Escherichia coli (285 aa), FASTA scores: opt: 275, E(): 1.1e-12, (33.8% identity in 201 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short chain dehydrogenase	1054247..1055008	Mycobacterium tuberculosis H37Rv	885629
NP_215461.1	CDS	pgi	NC_000962.2	1055024	1056685	R	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase	complement(1055024..1056685)	Mycobacterium tuberculosis H37Rv	885533
NP_215463.1	CDS	Rv0948c	NC_000962.2	1057646	1057963	R	Rv0948c, (MTCY10D7.26), len: 105 aa. Conserved hypothetical protein, equivalent to NP_301237.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (105 aa). Also similar (except in N-terminus) to SCD63.16c|CAB82023.1|AL161755 hypothetical protein from Streptomyces coelicolor (110 aa); and to N-terminus of two chorismate mutase/prephenate dehydratase.; hypothetical protein	complement(1057646..1057963)	Mycobacterium tuberculosis H37Rv	885485
YP_177772.1	CDS	uvrD1	NC_000962.2	1058260	1060575	D	Rv0949, (MTCY10D7.25c), len: 771 aa. Probable uvrD1, ATP dependent DNA helicase II (EC 3.6.1.-) (see citation below), equivalent to P_301239.1|NC_002677 putative ATP-dependent DNA helicase from Mycobacterium leprae (778 aa). Also highly similar to others e.g. CAB92660.1|AL356832 from Streptomyces coelicolor (831 aa) (N-terminus longer); P56255|PCRA_BACST from Bacillus stearothermophilus (724 aa); Q10213|YAY5_SCHPO from Schizosaccharomyces pombe (Fission yeast) (887 aa), FASTA scores: opt: 927, E(): 0, (33.5% identity in 659 aa overlap); etc. Also similar to several other UvrD-like proteins in Mycobacterium tuberculosis e.g. Rv3201c, Rv3198c, Rv3202c. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES. Note that previously known as uvrD.; uvrD; ATP-dependent DNA helicase II UVRD1	1058260..1060575	Mycobacterium tuberculosis H37Rv	885442
NP_215465.1	CDS	Rv0950c	NC_000962.2	1060656	1061654	R	Rv0950c, (MTCY10D7.24), len: 332 aa. Conserved hypothetical protein, highly similar to AL035500|MLCL373.02c|T45433 hypothetical protein from Mycobacterium leprae (343 aa), FASTA scores: opt: 1500, E(): 0, (71.0% identity in 331 aa overlap). C-terminus highly similar to part of various proteins e.g. C-terminal part of NP_441943.1|NC_000911|NlpD lipoprotein from Synechocystis sp (715 aa); N-terminal part of NP_066789.1|NC_002576 putative peptidase from Rhodococcus equi (546 aa); C-terminal part of NP_212396.1|NC_001318 conserved hypothetical protein from Borrelia burgdorferi (417 aa); C-terminal part of P33648|NLPD_ECOLI|nlpd lipoprotein from Escherichia coli (379 aa), FASTA scores: opt: 276, E(): 2e-10, (29.9% identity in 234 aa overlap); etc.; hypothetical protein	complement(1060656..1061654)	Mycobacterium tuberculosis H37Rv	885438
NP_215466.1	CDS	sucC	NC_000962.2	1061964	1063127	D	catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta	1061964..1063127	Mycobacterium tuberculosis H37Rv	885434
NP_215467.1	CDS	sucD	NC_000962.2	1063140	1064051	D	Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha	1063140..1064051	Mycobacterium tuberculosis H37Rv	885426
NP_215468.1	CDS	Rv0953c	NC_000962.2	1064114	1064962	R	Rv0953c, (MTCY10D7.21), len: 282 aa. Possible oxidoreductase (EC 1.-.-.-), equivalent to CAA48222.1|X68102 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (166 aa). Similar to several hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); NP_070025.1|NC_000917 N5,N10-methylenetetrahydromethanopterin reductase (mer-2) from Archaeoglobus fulgidus (348 aa); etc. Also similar to several hypothetical proteins and oxidoreductases from Mycobacterium tuberculosis e.g. Rv2161c|O06216|Z95388|MTCY270.07 (288 aa), FASTA scores: opt: 633, E(): 0, (40.4% identity in 277 aa overlap), Rv3079c (275 aa), Rv0791c (347 aa), etc. Contains PS00201 Flavodoxin signature.; oxidoreductase	complement(1064114..1064962)	Mycobacterium tuberculosis H37Rv	885419
NP_215469.1	CDS	Rv0954	NC_000962.2	1065127	1066038	D	Rv0954, (MTCY10D7.20c), len: 303 aa. Probable conserved transmembrane protein, highly similar to 34KD_MYCPA|Q04959 34 kDa antigenic protein from Mycobacterium paratuberculosis (298 aa), FASTA scores: opt: 1023, E(): 7.2e-36, (59.3% identity in 305 aa overlap); AAC69251.1|U82111 34 kDa antigen precursor from Mycobacterium leprae (336 aa); and AL035500|MLCL373.06 hypothetical membrane protein from Mycobacterium leprae (297 aa), FASTA score: (55.6% identity in 315 aa overlap).; transmembrane protein	1065127..1066038	Mycobacterium tuberculosis H37Rv	885411
NP_215470.1	CDS	Rv0955	NC_000962.2	1066078	1067445	D	Rv0955, (MTCY10D7.19c), len: 455 aa. Probable conserved integral membrane protein, highly similar to AL035500|MLCL373_6 putative membrane protein from Mycobacterium leprae (430 aa), FASTA score: (75.9% identity in 419 aa overlap); and AAL05878.1|AF411607_2|AF411607 unknown protein from Mycobacterium avium subsp. paratuberculosis (409 aa).; integral membrane protein	1066078..1067445	Mycobacterium tuberculosis H37Rv	885408
NP_215471.1	CDS	purN	NC_000962.2	1067561	1068208	D	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase	1067561..1068208	Mycobacterium tuberculosis H37Rv	885407
NP_215472.1	CDS	purH	NC_000962.2	1068205	1069776	D	involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	1068205..1069776	Mycobacterium tuberculosis H37Rv	885406
NP_215473.1	CDS	Rv0958	NC_000962.2	1069883	1071262	D	Rv0958, (MTCY10D7.16c), len: 459 aa. Possible magnesium chelatase (EC 4.99.1.-), similar to others (especially in N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 putative magnesium protoporphyrin chelatase from Deinococcus radiodurans (487 aa), FASTA scores: opt: 1148, E(): 0, (42.4% identity in 450 aa overlap); Q44498|CHLI_ANAVA MAGNESIUM-CHELATASE SUBUNIT CHLI from Anabaena variabilis (338 aa); T31460 probable magnesium chelatase (EC 4.99.1.-) chain I bchI from Heliobacillus mobilis (363 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; magnesium chelatase	1069883..1071262	Mycobacterium tuberculosis H37Rv	885405
NP_215474.1	CDS	Rv0959	NC_000962.2	1071255	1073273	D	Rv0959, (MTCY10D7.15c), len: 672 aa. Conserved hypothetical protein, similar to AE002069|AE002069_12 hypothetical protein from Deinococcus radiodurans (403 aa), FASTA scores: opt: 395, E(): 1.3e-15, (26.8% identity in 426 aa overlap). Contains a single copy at the N-terminus of a short repeat found three times in the M. tuberculosis ORF O33341|MTV003.05c|AL008883.; hypothetical protein	1071255..1073273	Mycobacterium tuberculosis H37Rv	885329
NP_215475.1	CDS	Rv0960	NC_000962.2	1073545	1073928	D	Rv0960, (MTCY10D7.14c), len: 127 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv0065|MTV030.08 (133 aa), FASTA scores: E(): 1.5e-14, (38.3% identity in 128 aa overlap), Rv1720c (129 aa), and Rv0549c (137 aa).; hypothetical protein	1073545..1073928	Mycobacterium tuberculosis H37Rv	885158
NP_215476.1	CDS	Rv0961	NC_000962.2	1074074	1074421	D	Rv0961, (MTCY10D7.13c), len: 115 aa. Probable integral membrane protein.; integral membrane protein	1074074..1074421	Mycobacterium tuberculosis H37Rv	885173
NP_215477.1	CDS	lprP	NC_000962.2	1074440	1075114	R	Rv0962c, (MTCY10D7.12), len: 224 aa. Possible lprP, lipoprotein. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LprP	complement(1074440..1075114)	Mycobacterium tuberculosis H37Rv	885177
NP_215478.1	CDS	Rv0963c	NC_000962.2	1075297	1076097	R	Rv0963c, (MTCCY10D7.11), len: 266 aa. Conserved hypothetical protein, similar in part to other CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: E(): 1.2e-23, (39.0% identity in 254 aa overlap); Rv2542 (403 aa); Rv2079 (656 aa). Also similar in part to AL133423|SC4A7_3 HYPOTHETICAL SECRETED PROTEIN from Streptomyces coelicolor (406 aa), FASTA scores: opt: 231, E(): 6.8e-07, (31.4% identity in 204 aa overlap); and SCH10.21c|T36533 hypothetical protein from Streptomyces coelicolor (329 aa).; hypothetical protein	complement(1075297..1076097)	Mycobacterium tuberculosis H37Rv	885184
NP_215479.1	CDS	Rv0964c	NC_000962.2	1076196	1076678	R	Rv0964c, (MTCY10D7.10), len: 160 aa. Hypothetical unknown protein. Equivalent to AAK45241.1 from Mycobacterium tuberculosis strain CDC1551 (138 aa) but longer 22 aa.; hypothetical protein	complement(1076196..1076678)	Mycobacterium tuberculosis H37Rv	885186
NP_215480.1	CDS	Rv0965c	NC_000962.2	1076778	1077197	R	Rv0965c, (MTCY10D7.09), len: 139 aa. Conserved hypothetical protein, showing weak similarity with Rv2798c|MTCY16B7.45 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (108 aa), FASTA scores: E(): 5.6e-12, (38.9% identity in 90 aa overlap). Equivalent to AAK45242.1 from Mycobacterium tuberculosis strain CDC1551 (146 aa) but shorter 7 aa.; hypothetical protein	complement(1076778..1077197)	Mycobacterium tuberculosis H37Rv	885230
NP_215481.2	CDS	Rv0966c	NC_000962.2	1077233	1077835	R	Rv0966c, (MTCY10D7.08), len: 200 aa. Conserved hypothetical protein, equivalent to AL035500|MLCL373_12 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (200 aa), FASTA scores: opt: 1080, E(): 0, (79.5% identity in 200 aa overlap). Also highly similar to SCE6.30c|CAB88834.1|AL353832 hypothetical protein from Streptomyces coelicolor (277 aa). Some similarity to Rv2862c|MTV007.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (194 aa), FASTA scores: E(): 3.1e-06, (31.5% identity in 184 aa overlap). Equivalent to AAK45243.1 from Mycobacterium tuberculosis strain CDC1551 (230 aa) but shorter 30 aa. Note that Rv0966c has been shortened since first entry.; hypothetical protein	complement(1077233..1077835)	Mycobacterium tuberculosis H37Rv	885043
NP_215482.1	CDS	Rv0967	NC_000962.2	1077975	1078334	D	Rv0967, (MTCY10D7.07c), len: 119 aa. Conserved hypothetical protein, similar to hypothetical proteins from several organisms e.g. AE002074|AE002074_11 from Deinococcus radiodurans (102 aa), FASTA scores: opt: 233, E(): 8.6e-10, (47.0% identity in 83 aa overlap); O32222|Z99121|YVGZ from Bacillus subtilis (101 aa), FASTA scores: opt:228, E(): 3.2e-15, (38.0% identity in 92 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0190, and Rv1766.; hypothetical protein	1077975..1078334	Mycobacterium tuberculosis H37Rv	885312
NP_215483.1	CDS	Rv0968	NC_000962.2	1078391	1078687	D	Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved hypothetical protein, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1% identity in 94 aa overlap); and Rv1993c (90 aa).; hypothetical protein	1078391..1078687	Mycobacterium tuberculosis H37Rv	885052
NP_215484.1	CDS	ctpV	NC_000962.2	1078743	1081055	D	Rv0969, (MTCY10D7.05c), len: 770 aa. Probable ctpV, metal cation transporter P-type ATPase (transmembrane protein) (EC 3.6.3.-) (see citation below), highly similar (except in N-terminus) to others e.g. NP_391230.1|NC_000964 similar to heavy metal-transporting ATPase from Bacillus subtilis (803 aa); P37279|ATCS_SYNP7|PACS cation-transporting ATPase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (747 aa), FASTA scores: opt: 1851, E(): 0, (52.1% identity in 664 aa overlap); etc. Equivalent to AAK45246.1 from Mycobacterium tuberculosis strain CDC1551 (792 aa) but shorter 22 aa. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES).; metal cation transporter P-type ATPase CtpV	1078743..1081055	Mycobacterium tuberculosis H37Rv	885254
NP_215485.1	CDS	Rv0970	NC_000962.2	1081052	1081684	D	Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa).; integral membrane protein	1081052..1081684	Mycobacterium tuberculosis H37Rv	885242
NP_215486.1	CDS	echA7	NC_000962.2	1081775	1082584	R	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	complement(1081775..1082584)	Mycobacterium tuberculosis H37Rv	885308
NP_215487.1	CDS	fadE12	NC_000962.2	1082584	1083750	R	Rv0972c, (MTCY10D7.02), len: 388 aa. Probable fadE12, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. CAB95893.1|AL359988 putative acyl CoA dehydrogenase from Streptomyces coelicolor (382 aa); P45857|ACDB_BACSU from Bacillus subtilis (379 aa), FASTA scores: opt: 576, E(): 2.3e-26, (29.7% identity in 381 aa overlap); etc.; acyl-CoA dehydrogenase FADE12	complement(1082584..1083750)	Mycobacterium tuberculosis H37Rv	885237
NP_215488.1	CDS	accA2	NC_000962.2	1083747	1085750	R	Rv0973c, (MTV044.01c, MTCY10D7.01), len: 667 aa. Probable accA2 (alternate gene name: bccA), acetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [INCLUDES: BIOTIN CARBOXYLASE (EC 6.3.4.14); BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)], highly similar to others e.g. CAB95892.1|AL359988 putative acetyl/propionyl CoA carboxylase alpha subunit from Streptomyces coelicolor (614 aa); NP_250702.1|NC_002516 probable acyl-CoA carboxylase alpha chain from Pseudomonas aeruginosa (655 aa); NP_420971.1|NC_002696 acetyl/propionyl-CoA carboxylase alpha subunit from Caulobacter crescentus ( 654 aa); NP_251581.1|NC_002516 probable biotin carboxylase/biotin carboxyl carrier protein from Pseudomonas aeruginosa (661 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv2501c|P46401|MTCY07A7.07c|BCCA_MYCTU|ACCA1 PROBABLE ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN (ALPHA SUBUNIT) (654 aa), FASTA scores, opt: 250, E(): 4e-09, (28.6% identity in 182 aa overlap); and Rv3285|MTCY71.25|ACCA3 (600 aa); Z83018|MTCY349_20 (1127 aa), FASTA scores: opt: 838, E(): 0, (40.2% identity in 500 aa overlap). Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site.; bccA; acetyl-/propionyl-coenzyme A carboxylase subunit alpha	complement(1083747..1085750)	Mycobacterium tuberculosis H37Rv	885922
NP_215489.1	CDS	accD2	NC_000962.2	1085756	1087345	R	Rv0974c, (MTV044.02c), len: 529 aa. Probable accD2, acetyl-/propionyl-CoA carboxylase (beta subunit) (EC 6.4.1.-), highly similar to many e.g. CAB95891.1|AL35998 putative acetyl/propionyl CoA carboxylase beta subunit from Streptomyces coelicolor (532 aa); NP_250704.1|NC_002516 probable acyl-CoA carboxyltransferase beta chain from Pseudomonas aeruginosa (535 aa); BAB16296.1|AB039884 acetyl-CoA carboxylase carboxyltransferase from Myxococcus xanthus (538 aa); NP_420973.1|NC_002696 putative propionyl-CoA carboxylase beta subunit from Caulobacter crescentus (530 aa); etc. Also similar to other from Mycobacterium tuberculosis: Rv2502c|ACCD1, Rv3799c|ACCD4, etc. COULD BELONG TO THE ACCD/PCCB FAMILY. TBparse score is 0.875.; acetyl-/propionyl-CoA carboxylase subunit beta	complement(1085756..1087345)	Mycobacterium tuberculosis H37Rv	886064
NP_215490.1	CDS	fadE13	NC_000962.2	1087348	1088496	R	Rv0975c, (MTV044.03c), len: 382 aa. Probable fadE13, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. T35427 probable acyl-CoA dehydrogenase from Streptomyces coelicolor (382 aa); M74096|HUMACADL_1 Human long chain acyl-CoA dehydrogenase from Homo sapiens (430 aa), FASTA scores: opt: 819, E(): 0, (37.0% identity in 376 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. fadE20|Z98209|MTCY154_4 (386 aa), FASTA scores: (40.3% identity in 375 aa overlap). Contains PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE13	complement(1087348..1088496)	Mycobacterium tuberculosis H37Rv	885856
NP_215491.1	CDS	Rv0976c	NC_000962.2	1088493	1090175	R	Rv0976c, (MTV044.04c), len: 560 aa. Conserved hypothetical protein, highly similar to others e.g. CAB95890.1|AL359988 conserved hypothetical protein from Streptomyces coelicolor (558 aa); P_251576.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (600 aa); etc. N-terminal part highly similar to AL035500|MLCL373_14 probable pseudogene from Mycobacterium leprae (163 aa), FASTA score: (50.0% identity in 122 aa overlap). TBparse score is 0.860.; hypothetical protein	complement(1088493..1090175)	Mycobacterium tuberculosis H37Rv	885860
YP_177773.1	CDS	PE_PGRS16	NC_000962.2	1090373	1093144	D	Rv0977, (MTV044.05), len: 923 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to other PGRS-type sequences e.g. AL0091|MTV004_1 from Mycobacterium tuberculosis (1125 aa), FASTA score: (45.4% identity in 959 aa overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa), FASTA score: (51.5% identity in 750 aa overlap); etc. TBparse score is 0.868.; PE-PGRS family protein	1090373..1093144	Mycobacterium tuberculosis H37Rv	885264
YP_177774.1	CDS	PE_PGRS17	NC_000962.2	1093361	1094356	R	Rv0978c, (MTV044.06c), len: 331 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to others e.g. Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 aa), FASTA score: (73.6% identity in 277 aa overlap); etc. TBparse score is 0.861.; PE-PGRS family protein	complement(1093361..1094356)	Mycobacterium tuberculosis H37Rv	885077
NP_215494.2	CDS	Rv0979c	NC_000962.2	1094670	1094864	R	Rv0979c, (MTV044.07c), len: 64 aa (unlikely ORF). Hypothetical unknown protein. Start codon changed since first submission (-44 aa).; hypothetical protein	complement(1094670..1094864)	Mycobacterium tuberculosis H37Rv	885063
YP_177635.1	CDS	rpmF	NC_000962.2	1094886	1095059	D	some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32	1094886..1095059	Mycobacterium tuberculosis H37Rv	3205057
YP_177775.1	CDS	PE_PGRS18	NC_000962.2	1095078	1096451	R	Rv0980c, (MTV044.08c), len: 457 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002), highly similar to others e.g. Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 aa), FASTA score: (66.7% identity in 405 aa overlap); Z95844|MTCY493_2 from Mycobacterium tuberculosis (741 aa), FASTA score: (53.0% identity in 394 aa overlap); etc.; PE-PGRS family protein	complement(1095078..1096451)	Mycobacterium tuberculosis H37Rv	885327
NP_215496.1	CDS	mprA	NC_000962.2	1096816	1097508	D	Rv0981, (MTV044.09), len: 230 aa. mprA, mycobacterial persistence regulator, a two-component response regulator whose expression is required for entrance into and maintenance of persistent infection (see citation below), equivalent to NP_301250.1|NC_002677 putative two-component response regulator from Mycobacterium leprae (228 aa); and highly similar to others from Mycobacterium leprae. Also highly similar to others e.g. AAG36759.1|AF119221_1|AF119221 response regulator from Corynebacterium glutamicum (232 aa); CAB88489.1|AL353816 putative two-component system response regulator from Streptomyces coelicolor (248 aa); BJY09666_1 two-component response regulator (ragA, ragB and rpoH3) from B.japonicum (226 aa), FASTA score: (43.8% identity in 224 aa overlap); BSAJ2571_44 two-component response regulator from Bacillus subtilis (228 aa), FASTA score: (46.4% identity in 224 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv1033c (257 aa); Rv0903c (236 aa), FASTA score: (50.7 identity in 225 aa overlap); etc. Contains PS00217 Sugar transport proteins signature 2.; two component response transcriptional regulatory protein MprA	1096816..1097508	Mycobacterium tuberculosis H37Rv	885038
NP_215497.1	CDS	mprB	NC_000962.2	1097508	1099022	D	Rv0982, (MTV044.10), len: 504 aa. Probable mprB, two component sensor kinase, transmembrane protein (EC 2.7.3.-) (see citation below), equivalent to AL035500|MLCL373_16|NP_301251.1|NC_002677 putative two-component system sensor kinase from Mycobacterium leprae (519 aa), FASTA score: (81.0% identity in 521 aa overlap). Also highly similar to others (especially in C-terminal part) e.g. AAG36760.1|AF119221_2|AF119221 sensor kinase from Corynebacterium glutamicum (455 aa); CAB89748.1|AL354616 putative two-component histidine kinase from Streptomyces coelicolor (481 aa); X58793|SLCUTRS_2 sensor kinase from S.lividans (414 aa), FASTA scores: opt: 451, E(): 4.2e-21, (36.0% identity in 303 aa overlap); P30847|BAES_ECOLI SENSOR PROTEIN (EC 2.7.3.-) from Escherichia coli (467 aa), FASTA scores: opt: 412, E(): 1.3e-18, (30.4% identity in 336 aa overlap); etc. Also similar in C-terminal region to C-terminus of Rv0902c|Z73101|MTCY31_33 from Mycobacterium tuberculosis (446 aa), FASTA scores: opt: 423, E(): 2.6e-19, (28.4 identity in 462 aa overlap).; two component sensor kinase MprB	1097508..1099022	Mycobacterium tuberculosis H37Rv	885062
NP_215498.1	CDS	pepD	NC_000962.2	1099066	1100460	D	Rv0983, (MTV044.11), len: 464 aa. Probable pepD (alternate gene name: mtb32b), secreted or membrane serine protease (EC 3.4.21.-) (see citation below), equivalent (but longer 18 aa in N-terminus) to AL035500|MLCL373_17|T45448 probable serine proteinase (EC 3.4.21.-) from Mycobacterium leprae (452 aa), FASTA score: (74.2% identity in 466 aa overlap); and highly similar to others from Mycobacterium leprae. Also highly similar (except in N-terminus) to other proteases e.g. CAC01350.1|AL390975 putative protease from Streptomyces coelicolor (542 aa); NP_440705.1|NC_000911|HtrA serine protease from Synechocystis sp. (452 aa); NP_346646.1|NC_003028 serine protease from Streptococcus pneumoniae (393 aa); etc. Also similar in part to members of the htrA-antigen family e.g. U87242|MTU87242_3|HtrA serine protease from M. tuberculosis (542 aa), FASTA scores: opt: 846, E(): 2e-28, (40.6% identity in 392 aa overlap); and similar to other hypothetical serine proteases e.g. Rv0983, Rv0125, etc. BELONGS TO THE SERINE PROTEASE FAMILY.; mtb32b; serine protease PepD	1099066..1100460	Mycobacterium tuberculosis H37Rv	885382
NP_215499.1	CDS	moaB2	NC_000962.2	1100460	1101005	D	Rv0984, (MTV044.12), len: 181 aa. Possible moaB2, pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96), highly similar to NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa), FASTA score: (92.3% identity in 181 aa overlap). Also similar to others e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa); Q56208|MOCB_SYNP7 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN CB from Synechococcus sp. (319 aa), FASTA score: (37.3% identity in 142 aa overlap); C-terminus of NP_197599.1|NC_003076 MOLYBDOPTERIN BIOSYNTHESIS CNX1 PROTEIN from Arabidopsis thaliana (670 aa); etc. Also similar to Rv0865|MOG from Mycobacterium tuberculosis (160 aa); and other mog proteins e.g. CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa). COULD BELONG TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. Alternative start codon has been suggested in position 1100508.; pterin-4-alpha-carbinolamine dehydratase MoaB2	1100460..1101005	Mycobacterium tuberculosis H37Rv	885378
NP_215500.1	CDS	mscL	NC_000962.2	1101025	1101480	R	forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel	complement(1101025..1101480)	Mycobacterium tuberculosis H37Rv	885368
NP_215501.1	CDS	Rv0986	NC_000962.2	1101803	1102549	D	Rv0986, (MTV044.14), len: 248 aa. Probable ATP-binding protein ABC transporter supposed involved in transport of adhesion component (see citation below), highly similar to many ATP-binding proteins e.g. AE0010|AE001033_8 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 669, E(): 0, (45.7% identity in 219 aa overlap); CAB81857.1|AL161691 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (246 aa); X84019|ZMDNAGRP_4 glutamate uptake regulatory protein (grp) from Z.mobilis (232 aa), FASTA score: (44.4% identity in 225 aa overlap); Z99111|BSUB0008_108 from Bacillus subtilis (230 aa), FASTA score: (38.7% identity in 222 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; adhesion component transport ATP-binding protein ABC transporter	1101803..1102549	Mycobacterium tuberculosis H37Rv	885364
NP_215502.1	CDS	Rv0987	NC_000962.2	1102542	1105109	D	Rv0987, (MTV044.15, MTCI237.01), len: 855 aa. Probable transmembrane protein ABC transporter supposed involved in transport of adhesion component (see citation below), whose N-terminus shows similarity with hypothetical proteins, generally transmembrane proteins, e.g. CAB96016.1|AL360055 putative ABC transport system integral membrane protein from Streptomyces coelicolor (855 aa); P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from Haemophilus influenzae (393 aa), FASTA scores: opt: 265, E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N- and C-termini respectively show similarity to O32735 ATTF PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa), FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; adhesion component transport transmembrane protein ABC transporter	1102542..1105109	Mycobacterium tuberculosis H37Rv	885363
NP_215503.1	CDS	Rv0988	NC_000962.2	1105116	1106276	D	Rv0988, (MTCI237.02), len: 386 aa. Possible conserved exported protein, with potential N-terminal signal sequence, similar (except in N-terminus) to O32737|L63540 ATTH PROTEIN from Agrobacterium tumefaciens (355 aa), FASTA scores: opt: 651, E(): 5.7e-33, (33.4% identity in 344 aa overlap); and NP_231265.1|NC_002505 conserved hypothetical protein from Vibrio cholerae (372 aa).; hypothetical protein	1105116..1106276	Mycobacterium tuberculosis H37Rv	885353
NP_215504.1	CDS	grcC2	NC_000962.2	1106405	1107382	R	Rv0989c, (MTCI237.03c), len: 325 aa. Probable grcC2, polyprenyl diphosphate synthetase (EC 2.5.1.-), highly similar to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta (EC 2.5.1.30) or hexaprenyl e.g. NP_471378.1|NC_003212 protein similar to heptaprenyl diphosphate synthase component II (menaquinone biosynthesis) from Listeria innocua (321 aa); NP_371994.1|NC_002758 heptaprenyl diphosphate syntase component II from Staphylococcus aureus subsp. aureus Mu50 (319 aa); P55785|HEP2_BACST heptaprenyl diphosphate synthase component from Bacillus subtilis (323 aa), FASTA scores: opt: 496, E(): 1.4e-24, (31.4% identity in 306 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins e.g. Rv0562|grcC1|NP_215076.1|MTCY25D10.41 PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE (335 aa); Rv3383, Rv3398c, Rv2173, etc. SEEMS TO BELONG TO THE FPP/GGPP SYNTHETASES FAMILY.; polyprenyl-diphosphate synthase	complement(1106405..1107382)	Mycobacterium tuberculosis H37Rv	885355
NP_215505.1	CDS	Rv0990c	NC_000962.2	1107443	1108099	R	Rv0990c, (MTCI237.04c), len: 218 aa. Hypothetical unknown protein.; hypothetical protein	complement(1107443..1108099)	Mycobacterium tuberculosis H37Rv	885343
NP_215506.1	CDS	Rv0991c	NC_000962.2	1108172	1108504	R	Rv0991c, (MTCI237.05c), len: 110 aa. Conserved hypothetical ser-rich protein (especially in C-terminus), highly similar to N-terminus of NP_301255.1|NC_002677 conserved hypothetical protein (Ser-rich C-terminus) from Mycobacterium leprae (99 aa). Also highly similar to SCE22.04|AB90971.1|AL355832 hypothetical protein from Streptomyces coelicolor (110 aa); and similar to others.; putative serine rich protein	complement(1108172..1108504)	Mycobacterium tuberculosis H37Rv	885350
NP_215507.1	CDS	Rv0992c	NC_000962.2	1108578	1109171	R	Rv0992c, (MTCI237.06c), len: 197 aa. Conserved hypothetical protein, equivalent to NP_301256.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (197 aa). Also similar, except in N-terminus, to other hypothetical proteins and ligases e.g. SCE87.34|CAB59679.1|AL132674 hypothetical protein from Streptomyces coelicolor (204 aa); NP_461977.1|NC_003197 putative ligase from Salmonella typhimurium (182 aa); P09160|YGFA_ECOLI HYPOTHETICAL 21.1 kDa PROTEIN from Escherichia coli (182 aa), FASTA scores: opt: 191, E(): 1.1e-09, (29.5% identity in 146 aa overlap); etc.; hypothetical protein	complement(1108578..1109171)	Mycobacterium tuberculosis H37Rv	885337
NP_215508.1	CDS	galU	NC_000962.2	1109272	1110192	D	Rv0993, (MTCI237.07), len: 306 aa. Probable galU, UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9), equivalent to AL035500|MLCL373_22 putative UTP-glucose-1-phosphate uridylyltransferase from Mycobacterium leprae (306 aa), FASTA score: (89.7% identity in 302 aa overlap). Also highly similar to others e.g. AB59678.1|AL132674 UTP-glucose-1-phosphate uridylyltransferase from Streptomyces coelicolor (303 aa); NP_244519.1|NC_002570 UTP-glucose-1-phosphate uridylyltransferase from Bacillus halodurans (297 aa); P25520|GALU_ECOLI|B1236|Z2012|ECS17 UTP--glucose-1-phosphate uridylyltransferase from Escherichia coli strains K12 and O157:H7 (301 aa), FASTA scores: opt: 624, E(): 2.4e-33, (38.8% identity in 299 aa overlap); etc. BELONGS TO THE PROKARYOTIC UDPGP FAMILY.; UTP--glucose-1-phosphate uridylyltransferase GalU	1109272..1110192	Mycobacterium tuberculosis H37Rv	885341
YP_177776.1	CDS	moeA1	NC_000962.2	1110269	1111549	D	Rv0994, (MTCI237.08), len: 426 aa. Probable moeA1, molybdenum cofactor biosynthesis protein, equivalent to AL035500|MLCL373_23 putative molybdopterin biosynthesis protein from Mycobacterium leprae (424 aa), FASTA score: (88.3% identity in 426 aa overlap). Also highly similar to many e.g. CAB59677.1|AL132674 molybdopterin biosynthesis protein from Streptomyces coelicolor (424 aa); NP_385769.1|NC_003047 PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Sinorhizobium meliloti (406 aa); P12281|MOEA_ECOLI molybdopterin biosynthesis moea protein from Escherichia coli (411 aa), FASTA scores: opt: 519, E(): 1.3e-24, (32.3% identity in 402 aa overlap); etc. Also similar to MOEA2|Rv0438c|MTV037.02c PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (405 aa). Note that previously known as moeA.; moeA; molybdopterin biosynthesis protein MoeA1	1110269..1111549	Mycobacterium tuberculosis H37Rv	885404
NP_215510.1	CDS	rimJ	NC_000962.2	1111612	1112223	D	Rv0995, (MTCI237.09), len: 203 aa. Possible rimJ, ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), equivalent to AL035500|MLCL373_24 probable acyltransferase from Mycobacterium leprae (218 aa), FASTA scores: (86.0% identity in 200 aa overlap). Also similar to others and many acyltransferases e.g. BAB69252.1|AB070946 possible acyltransferase from Streptomyces avermitilis (156 aa); NP_385025.1|NC_003047 PROBABLE RIBOSOMAL-PROTEIN-ALANINE ACETYLTRANSFERASE from Sinorhizobium meliloti (203 aa); P09454|RIMJ_ECOLI|B1066|Z1703|ECS1444 ribosomal-protein-alanine acetyltransferase from Escherichia coli strains K12 and O157:H7 (194 aa), FASTA scores: opt: 247, E(): 1.5e-10, (26.9% identity in 186 aa overlap). SEEMS TO BELONG TO THE ACETYLTRANSFERASE FAMILY, RIMJ SUBFAMILY.; ribosomal-protein-alanine acetyltransferase	1111612..1112223	Mycobacterium tuberculosis H37Rv	885399
NP_215511.1	CDS	Rv0996	NC_000962.2	1112384	1113460	D	Rv0996, (MTCI237.10), len: 358 aa. Probable conserved transmembrane protein, equivalent to AL035500|MLCL373_25 putative membrane protein from Mycobacterium leprae (342 aa), FASTA scores: (66.4% identity in 360 aa overlap). Contains possible signal sequence and other hydrophobic domains.; transmembrane protein	1112384..1113460	Mycobacterium tuberculosis H37Rv	885393
NP_215512.1	CDS	Rv0997	NC_000962.2	1114293	1114724	D	Rv0997, (MTCI237.11), len: 143 aa. Hypothetical unknown protein, equivalent to AAK45276.1 from Mycobacterium tuberculosis strain CDC1551 (87 aa) but longer 56 aa.; hypothetical protein	1114293..1114724	Mycobacterium tuberculosis H37Rv	885386
NP_215513.1	CDS	Rv0998	NC_000962.2	1114748	1115749	D	Rv0998, (MTCI237.12), len: 333 aa. Conserved hypothetical protein, possibly cyclic nucleotide-dependent protein kinase (EC 2.7.-.-), highly similar to NP_301261.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (353 aa); and AL035500|MLCL373.38|T45457 hypothetical protein from Mycobacterium leprae (143 aa), FASTA score: (61.5% identity in 143 aa overlap). Also similar to many hypothetical proteins and cyclic-NMP-dependent protein kinases (generally at C-terminus) e.g. N-terminus of SC9B10.09|T35878 hypothetical protein from Streptomyces coelicolor (1039 aa); P05987|KAPR_DICDI CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN (EC 2.7.1.37) from Dictyostelium discoideum (327 aa), FASTA scores: opt: 177, E(): 0.00036, (32.0% identity in 122 aa overlap); NP_104403.1|NC_002678 hypothetical protein (contains similarity to cAMP-dependent protein kinase regulatory subunit) from Mesorhizobium loti (151 aa); etc. Contains PS00889 Cyclic nucleotide-binding domain signature 2.; hypothetical protein	1114748..1115749	Mycobacterium tuberculosis H37Rv	885385
NP_215514.1	CDS	Rv0999	NC_000962.2	1115767	1116525	D	Rv0999, (MTCI237.13), len: 252 aa. Hypothetical unknown protein.; hypothetical protein	1115767..1116525	Mycobacterium tuberculosis H37Rv	886043
YP_177777.1	CDS	Rv1000c	NC_000962.2	1116531	1117148	R	Rv1000c, len: 205 aa. Conserved hypothetical protein, equivalent to ML0190|NP_301263.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (205 aa). Also highly similar to SC5F8.12c|CAB93740.1|AL357613 hypothetical protein from Streptomyces coelicolor (210 aa), FASTA scores: E(): 2.1e-45, (56.8% identity); 9106290|AAF84108.1|AE003963_5|NP_298588.1|NC_002488 protein described as DNA repair system specific for alkylated DNA from Xylella fastidiosa (200 aa), FASTA scores: E(): 3.4e-14, (38.55% identity); and similar in C-terminus to other hypothetical proteins. Note that replaces original Rv1000 predicted on other strand.; hypothetical protein	complement(1116531..1117148)	Mycobacterium tuberculosis H37Rv	886266
NP_215517.1	CDS	arcA	NC_000962.2	1117185	1118393	D	catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase	1117185..1118393	Mycobacterium tuberculosis H37Rv	888313
NP_215518.1	CDS	Rv1002c	NC_000962.2	1118428	1119939	R	Rv1002c, (MTCI237.17c), len: 503 aa. Conserved membrane protein. Similar to AL132674|SCE87.05 hypothetical protein from Streptomyces coelicolor (591 aa), FASTA scores: opt: 666, E(): 0, (39.0% identity in 546 aa overlap); weakly similar and to TSCC_PSEAM|P55019 thiazide-sensitive sodium-chloride cotransporter from Pseudopleuronectes americanus (1023 aa), FASTA scores: opt: 44, E(): 4.2e-06, (22.4% identity in 326 aa overlap).; hypothetical protein	complement(1118428..1119939)	Mycobacterium tuberculosis H37Rv	887882
NP_215519.1	CDS	Rv1003	NC_000962.2	1120022	1120879	D	Rv1003, (MTCI237.19), len: 285 aa. Conserved hypothetical protein, similar to others e.g. AL132674|SCE87.04 Streptomyces coelicolor (286 aa), FASTA scores: opt: 877, E(): 0, (53.2% identity in 280 aa overlap); and YRAL_ECOLI|P45528 hypothetical 31.3 kd protein (286 aa), FASTA scores: opt: 561, E(): 4.4e-27, (36.9% identity in 279 aa overlap).; hypothetical protein	1120022..1120879	Mycobacterium tuberculosis H37Rv	887935
NP_215520.1	CDS	Rv1004c	NC_000962.2	1120889	1122148	R	Rv1004c, (MTCI237.20c), len: 419 aa. Probable membrane protein. Contains repetitive sequences, which have similarities with elastin, and possible N-terminal signal sequence.; hypothetical protein	complement(1120889..1122148)	Mycobacterium tuberculosis H37Rv	886039
NP_215521.1	CDS	pabB	NC_000962.2	1122222	1123598	R	catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I	complement(1122222..1123598)	Mycobacterium tuberculosis H37Rv	888205
NP_215522.1	CDS	Rv1006	NC_000962.2	1123714	1125417	D	Rv1006, (MTCI237.23), len: 567 aa. Hypothetical unknown protein.; hypothetical protein	1123714..1125417	Mycobacterium tuberculosis H37Rv	888234
NP_215523.1	CDS	metG	NC_000962.2	1125444	1127003	R	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase	complement(1125444..1127003)	Mycobacterium tuberculosis H37Rv	886050
NP_215524.1	CDS	tatD	NC_000962.2	1127089	1127883	D	Rv1008, (MTCI237.25), len: 264 aa. Probable tatD (alternate gene name: yjjV), deoxyribonuclease (EC 3.1.21.-), component of twin arginine translocation protein export system (see citations below). Similar to many members of the YBL055C/YJJV family e.g. YCFH_ECOLI|P37346 Putative deoxyribonuclease ycfH (EC 3.1.21.-) (265 aa), fasta scores: opt: 487, E(): 1.4e-24, (36.7% identity in 270 aa overlap). Also similar to P37545|YABD_BACSU Putative deoxyribonuclease yabD (255 aa), FASTA scores: opt: 599, E(): 7.7e-33, (40.1% identity in 262 aa overlap). Contains PS01137 Hypothetical YBL055c/yjjV family signature 1, and PS01091 Hypothetical YBL055c/yjjV family signature 3.; yjjV; deoxyribonuclease TatD (YjjV protein)	1127089..1127883	Mycobacterium tuberculosis H37Rv	886047
NP_215525.1	CDS	rpfB	NC_000962.2	1128091	1129179	D	Rv1009, (MTCI237.26), len: 362 aa. Probable rpfB, resuscitation-promoting factor (see citation below), similar to others from Mycobacterium tuberculosis: Rv2450c|MTV008.06c|RPFE PROBABLE RESUSCITATION-PROMOTING FACTOR (172 aa), FASTA scores: E(): 1.9e-19, (42.9% identity in 147 aa overlap); Rv0867c|RPFA, Rv1884c|RPFC, and Rv2389c|RPFD. Possible lipoprotein; contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; resuscitation-promoting factor rpfB	1128091..1129179	Mycobacterium tuberculosis H37Rv	886048
NP_215526.1	CDS	ksgA	NC_000962.2	1129152	1130105	D	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase	1129152..1130105	Mycobacterium tuberculosis H37Rv	888792
NP_215527.1	CDS	ispE	NC_000962.2	1130191	1131111	D	catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	1130191..1131111	Mycobacterium tuberculosis H37Rv	886034
NP_215528.1	CDS	Rv1012	NC_000962.2	1131128	1131421	D	Rv1012, (MTCI237.29), len: 97 aa. Hypothetical unknown protein.; hypothetical protein	1131128..1131421	Mycobacterium tuberculosis H37Rv	886045
NP_215529.1	CDS	pks16	NC_000962.2	1131625	1133259	D	activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase	1131625..1133259	Mycobacterium tuberculosis H37Rv	886035
NP_215530.1	CDS	pth	NC_000962.2	1133333	1133908	R	Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase	complement(1133333..1133908)	Mycobacterium tuberculosis H37Rv	886037
NP_215531.1	CDS	rplY	NC_000962.2	1133921	1134568	R	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc	complement(1133921..1134568)	Mycobacterium tuberculosis H37Rv	885992
NP_215532.1	CDS	lpqT	NC_000962.2	1134785	1135465	R	Rv1016c, (MTCY10G2.33), len: 226 aa. Probable lpqT, conserved lipoprotein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv0040c|Y0H3_MYCTU|P71697 Proline rich 28 kDA antigen (310 aa), FASTA scores: opt: 329, E(): 2e-17, (32.3% identity in 229 aa overlap); Rv0583c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LpqT	complement(1134785..1135465)	Mycobacterium tuberculosis H37Rv	886066
NP_215533.1	CDS	prsA	NC_000962.2	1135501	1136481	R	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase	complement(1135501..1136481)	Mycobacterium tuberculosis H37Rv	885993
NP_215534.1	CDS	glmU	NC_000962.2	1136573	1138060	R	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	complement(1136573..1138060)	Mycobacterium tuberculosis H37Rv	886069
NP_215535.1	CDS	Rv1019	NC_000962.2	1138315	1138908	D	Rv1019, (MTCY10G2.30c), len: 197 aa. Probable transcriptional regulator, similar to many memebers of the tetR family e.g. MTCY7D11.18c (34.4% identity in 189 aa overlap). Helix turn helix motif from aa 27-48 (+5.42 SD).; TetR family transcriptional regulator	1138315..1138908	Mycobacterium tuberculosis H37Rv	886056
NP_215536.1	CDS	mfd	NC_000962.2	1138967	1142671	D	Rv1020, (MTCY10G2.29c), len: 1234 aa. Probable mfd (alternate gene name: trcF), transcription-repair coupling factor (see citation below), similar to many e.g. MFD_ECOLI|P30958 transcription-repair coupling factor from Escherichia coli (1148 aa), FASTA scores: opt: 1900, E(): 0, (37.9% identity in 1107 aa overlap); similar to M. tuberculosis Rv2973c and Rv1633. Contains PS00017 ATP/GTP-binding site motif A (P-loop). IN THE N-TERMINAL SECTION; BELONGS TO THE UVRB FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE HELICASE FAMILY. RECG SUBFAMILY.; trcF; transcription-repair coupling factor Mfd (TRCF)	1138967..1142671	Mycobacterium tuberculosis H37Rv	886077
NP_215537.1	CDS	Rv1021	NC_000962.2	1142671	1143648	D	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase	1142671..1143648	Mycobacterium tuberculosis H37Rv	886052
NP_215538.1	CDS	lpqU	NC_000962.2	1143736	1144467	D	Rv1022, (MTCY10G2.27c), len: 243 aa. Probable lpqU conserved lipoprotein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1230c|MTV006.02C, FASTA scores: E(): 2.8e-18, (37.9% identity in 240 aa overlap). Similar to AL133423|SC4A7.37 hypothetical protein from Streptomyces coelicolor (421 aa), FASTA scores: opt: 474, E(): 2.7e-21, (42.2% identity in 211 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LpqU	1143736..1144467	Mycobacterium tuberculosis H37Rv	886076
NP_215539.1	CDS	eno	NC_000962.2	1144564	1145853	D	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase	1144564..1145853	Mycobacterium tuberculosis H37Rv	886062
NP_215540.1	CDS	Rv1024	NC_000962.2	1145858	1146544	D	Rv1024, (MTCY10G2.25c), len: 228 aa. Possible conserved membrane protein, with a hydrophobic region from aa 83-101. Equivalent to ML0256|NP_301311.1|NC_002677 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (227 aa), S&W scores: 178, E()= 2e-72, Identities: 145/203 (71%).; hypothetical protein	1145858..1146544	Mycobacterium tuberculosis H37Rv	886059
NP_215541.1	CDS	Rv1025	NC_000962.2	1146561	1147028	D	Rv1025, (MTCY10G2.24c), len: 155 aa. Conserved hypothetical protein, similar to hypothetical protein AE001768|AE001768_4 Thermotoga maritima (170 aa) FASTA scores: opt: 254, E(): 9.5e-10, (35.7% identity in 143 aa overlap).; hypothetical protein	1146561..1147028	Mycobacterium tuberculosis H37Rv	886042
NP_215542.1	CDS	Rv1026	NC_000962.2	1147019	1147978	D	Rv1026, (MTCY10G2.23c), len: 319 aa. Conserved hypothetical protein. Similar to GPPA_ECOLI|P25552 guanosine-5'-triphosphate,3'-diphosphate pyrophoshatase from Escherichia coli (494 aa), FASTA scores: opt: 281, E(): 3.2e-11, (30.6% identity in 291 aa overlap). Equivalent to AL023514|MLCB4.02 hypothetical protein from Mycobacterium leprae (317 aa) (77.9% identity in 321 aa overlap).; hypothetical protein	1147019..1147978	Mycobacterium tuberculosis H37Rv	886089
NP_215543.1	CDS	kdpE	NC_000962.2	1148427	1149107	R	Rv1027c, (MTCY10G2.22), len: 226 aa. Probable KdpE, transcriptional regulatory protein, similar to others e.g. KDPE_ECOLI|P21866 kdp operon transcriptional regulatory protein from Escherichia coli strain K12 (225 aa), FASTA scores: opt: 691, E(): 0, (47.8% identity in 224 aa overlap); AL021530|SC2E9.13 from Streptomyces coelicolor (227 aa), FASTA scores: opt: 981, E(): 0, (66.4% identity in 226 aa overlap); etc.; transcriptional regulatory protein KdpE	complement(1148427..1149107)	Mycobacterium tuberculosis H37Rv	886046
NP_215544.1	CDS	kdpD	NC_000962.2	1149104	1151686	R	Rv1028c, (MTCY10G2.21), len: 860 aa. Probable kdpD, sensor protein (EC 2.7.3.-), similar to others e.g. KDPD_ECOLI|P21865 sensor protein from Escherichia coli strain K12 (894 aa), FASTA scores: opt: 1041, E(): 0, (32.3% identity in 888 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; sensor protein KDPD	complement(1149104..1151686)	Mycobacterium tuberculosis H37Rv	886084
YP_177636.1	CDS	kdpF	NC_000962.2	1151920	1152012	D	Rv1028A, len: 30 aa. Probable kdpF, membrane protein, showing similarity with P36937|KDPF_ECOLI|B0698.1 PROTEIN KDPF from Escherichia coli strain K12 (see citation below) (27% identity); and KdpF protein from Streptomyces coelicolor (51% identity).; membrane protein kdpF	1151920..1152012	Mycobacterium tuberculosis H37Rv	3205056
NP_215545.1	CDS	kdpA	NC_000962.2	1152012	1153727	D	catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A	1152012..1153727	Mycobacterium tuberculosis H37Rv	887414
NP_215546.1	CDS	kdpB	NC_000962.2	1153724	1155853	D	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B	1153724..1155853	Mycobacterium tuberculosis H37Rv	887343
NP_215547.1	CDS	kdpC	NC_000962.2	1155853	1156422	D	one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C	1155853..1156422	Mycobacterium tuberculosis H37Rv	886008
NP_215548.1	CDS	trcS	NC_000962.2	1156426	1157955	R	Rv1032c, (MTCY10G2.17), len: 509 aa. trcS, two component sensor histidine kinase protein (EC 2.7.3.-) (see citations below), similar to YV16_MYCLE|P54883 probable sensor-like histidine kinase from Mycobacterium leprae (443 aa), FASTA scores: opt: 392, E(): 3.8e-18, (31.7% identity in 334 aa overlap). Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+or Ca2+as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+.; two component sensor histidine kinase TRCS	complement(1156426..1157955)	Mycobacterium tuberculosis H37Rv	887790
NP_215549.1	CDS	trcR	NC_000962.2	1157963	1158736	R	Rv1033c, (MTCY10G2.16), len: 257 aa. trcR, two-component regulatory protein (see citations below), similar to Q50825 TWO COMPONENT RESPONSE REGULATOR from Mycobacterium tuberculosis (234 aa), FASTA scores: opt: 628, E(): 0, (46.0% identity in 226 aa overlap). Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+or Ca2+as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+.; two component transcriptional regulator TRCR	complement(1157963..1158736)	Mycobacterium tuberculosis H37Rv	887957
NP_215550.1	CDS	Rv1034c	NC_000962.2	1158918	1159307	R	Rv1034c, (MTCY10G2.15), len: 129 aa. Probable IS1560 transposase fragment, similar to part of Rv3387|E1202305|MTV004.45 (225 aa) (65.1% identity in 129 aa overlap).; transposase	complement(1158918..1159307)	Mycobacterium tuberculosis H37Rv	886010
NP_215551.1	CDS	Rv1035c	NC_000962.2	1159375	1160061	R	Rv1035c, (MTCY10G2.14), len: 228 aa. Probable IS1560 transposase fragment, similar to parts of Rv3387|E1202305|MTV004.45 (225 aa) (47.8% identity in 67 aa overlap) and Rv3386|E1202304|MTV004.44 (234 aa) (55.1% identity in 127 aa overlap).; transposase	complement(1159375..1160061)	Mycobacterium tuberculosis H37Rv	888206
NP_215552.1	CDS	Rv1036c	NC_000962.2	1160095	1160433	R	Rv1036c, (MTCY10G2.13), len: 112 aa. Probable IS1560 transposase fragment, similar to part of Rv3386|E1202304|MTV004.44 (234 aa) (82.8% identity in 87 aa overlap).; truncated IS1560 transposase	complement(1160095..1160433)	Mycobacterium tuberculosis H37Rv	888227
NP_215553.1	CDS	esxI	NC_000962.2	1160544	1160828	R	Rv1037c, (MTCY10G2.12), len: 94 aa. esxI, ESAT-6 like protein (see citations below), highly similar to Q49946|ES6X_MYCLE|U1756D PUTATIVE ESAT-6 LIKE PROTEIN X from Mycobacterium leprae (95 aa), FASTA scores: opt: 409, E(): 6.3e-23, (64.15% identity in 92 aa overlap); Rv3619c, Rv1198, Rv2346c, etc from Mycobacterium tuberculosis. Strictly identical to P96364|ES61_MYCTU|Rv3619c|MTCY15C10.33|MTCY07H7B.03|MT372 1 PUTATIVE ESAT-6 LIKE PROTEIN 1 (94 aa). BELONGS TO THE ESAT6 FAMILY.; ES6_1, Mtb9.9D; putative ESAT-6 like protein ESXI (ESAT-6 like protein 1)	complement(1160544..1160828)	Mycobacterium tuberculosis H37Rv	888299
NP_215554.1	CDS	esxJ	NC_000962.2	1160855	1161151	R	Rv1038c, (MT1067, MTCY10G2.11), len: 98 aa. esxJ, ESAT-6 like protein (see Gey Van Pittius et al., 2001), similar to Q49945|U1756C, Mycobacterium leprae (100 aa), FASTA scores: opt: 375, E(): 7.7e-21, (58.3% identity in 96 aa overlap). Member of M. tuberculosis hypothetical QILSS protein family with Rv1197, Rv1792, Rv2347c and Rv3620c. BELONGS TO THE ESAT6 FAMILY.; ES6_2, TB11.0, QILSS; Esat-6 like protein esxJ (Esat-6 like protein 2)	complement(1160855..1161151)	Mycobacterium tuberculosis H37Rv	888372
YP_177778.1	CDS	PPE15	NC_000962.2	1161297	1162472	R	Rv1039c, (MTCY10G2.10), len: 391 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv2768c|AL008967|MTV002_33 Mycobacterium tuberculosis H37Rv (394 aa), FASTA scores: opt: 1721, E(): 0, (70.4% identity in 398 aa overlap).; PPE family protein	complement(1161297..1162472)	Mycobacterium tuberculosis H37Rv	888477
YP_177779.1	CDS	PE8	NC_000962.2	1162549	1163376	R	Rv1040c, (MTCY10G2.09), len: 275 aa. Member of the Mycobacterium tuberculosis PE family (see citation below), most similar to AL008967|MTV002_34 Mycobacterium tuberculosis H37Rv (275 aa), FASTA scores: opt: 1111, E(): 0, (68.6% identity in 283 aa overlap).; PE family protein	complement(1162549..1163376)	Mycobacterium tuberculosis H37Rv	888533
NP_215557.1	CDS	Rv1041c	NC_000962.2	1164572	1165435	R	Rv1041c, (MTCY10G2.08), len: 287 aa. Probable IS like-2 transposase, overlaps MTCY10G2.07. Similar to Q00430|X53945 insertion element IS869 hypothetical protein from Agrobacterium tumefaciens (186 aa), FASTA scores: opt: 173, E(): 0.00016, (40.9% identity in 176 aa overlap). Similar to Rv1150, C-terminal part of transposase of putative Mycobacterium tuberculosis IS like-1. MTCY10G2.07 and MTCY10G2.08 are frameshifted with respect to Mycobacterium tuberculosis Q50761 transposase, the 10G2 cosmid sequence appears to be correct.; IS like-2 transposase	complement(1164572..1165435)	Mycobacterium tuberculosis H37Rv	888546
NP_215558.1	CDS	Rv1042c	NC_000962.2	1165092	1165499	R	Rv1042c, (MTCY10G2.07), len: 135 aa. Probable IS like-2 transposase, similar to Q50761 TRANSPOSASE from Mycobacterium tuberculosis (308 aa), FASTA scores: opt: 823, E(): 0, (99.1% identity in 117 aa overlap). Second copy is Rv1149.; IS like-2 transposase	complement(1165092..1165499)	Mycobacterium tuberculosis H37Rv	888607
NP_215559.1	CDS	Rv1043c	NC_000962.2	1165781	1166806	R	Rv1043c, (MTCY10G2.06), len: 341 aa. Conserved hypothetical protein similar to AL096872|SC5F7.08 PUTATIVE LIPOATE-PROTEIN LIGASE from Streptomyces coelicolor (362 aa), FASTA scores: opt: 206, E(): 1.4e-05, (30.3% identity in 201 aa overlap). Weak similarity to P39668|YYXA_BACSU HYPOTHETICAL PROTEASE from Bacillus subtitis (400 aa), FASTA scores: opt: 159, E(): 0.013, (27.1% identity in 210 aa overlap).; hypothetical protein	complement(1165781..1166806)	Mycobacterium tuberculosis H37Rv	888634
NP_215560.1	CDS	Rv1044	NC_000962.2	1167053	1167676	D	Rv1044, (MTCY10G2.05c), len: 207 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein MTCY06G11.02C|P96837 (289 aa), fasta scores: E(): 8.9e-06, (30.7% identity in 150 aa overlap). Some similarity to U36837|LLU36837_1 Lactococcus lactis plasmid pNP40 (287 aa), FASTA scores: opt: 147, E (): 0.0087, (29.7% identity in 91 aa overlap).; hypothetical protein	1167053..1167676	Mycobacterium tuberculosis H37Rv	888712
NP_215561.1	CDS	Rv1045	NC_000962.2	1167673	1168554	D	Rv1045, (MTCY10G2.04c), len: 293 aa. Hypothetical unknown protein.; hypothetical protein	1167673..1168554	Mycobacterium tuberculosis H37Rv	888783
NP_215562.2	CDS	Rv1046c	NC_000962.2	1168704	1169228	R	Rv1046c, (MTCY10G2.03), len: 174 aa. Hypothetical unknown protein. Start changed since first submission (-65 aa).; hypothetical protein	complement(1168704..1169228)	Mycobacterium tuberculosis H37Rv	886071
NP_215563.1	CDS	Rv1047	NC_000962.2	1169423	1170670	D	Rv1047, (MTCY10G2.02c), len: 415 aa. IS1081 transposase, most similar to TRA1_MYCBO|P35882 transposase for insertion sequence element (415 aa), FASTA scores: opt: 2675, E(): 0, (99.8% identity in 415 aa overlap). Contains PS01007 Transposases, Mutator family, signature; transposase	1169423..1170670	Mycobacterium tuberculosis H37Rv	886060
NP_215564.1	CDS	Rv1048c	NC_000962.2	1171038	1172153	R	Rv1048c, (MTV017.01c-MTCY10G2.01), len: 371 aa. Hypothetical unknown protein.; hypothetical protein	complement(1171038..1172153)	Mycobacterium tuberculosis H37Rv	885295
NP_215565.1	CDS	Rv1049	NC_000962.2	1172386	1172832	D	Rv1049, (MTV017.02), len: 148 aa. Probable transcriptional repressor protein, similar to many e.g. P74870 NEGATIVE REGULATOR OF EMR LOCUS EMR from Salmonella typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011, (31.6% identity in 95 aa overlap). TBparse score is 0.892. Contains probable helix-turn -helix motif at aa 58-79 (Score 1495, +4.28 SD).; transcriptional repressor protein	1172386..1172832	Mycobacterium tuberculosis H37Rv	886091
NP_215566.1	CDS	Rv1050	NC_000962.2	1172881	1173786	D	Rv1050, (MTV017.03), len: 301 aa. Probable oxidoreductase (EC 1.-.-.-) similar to many e.g. Rv1543|MTCY48.22C|Q10783 PUTATIVE OXIDOREDUCTASE CY48.22C (341 aa), FASTA scores: opt: 462, E(): 3e-22, (33.6% identity in 265 aa overlap). TBparse score is 0.896.; oxidoreductase	1172881..1173786	Mycobacterium tuberculosis H37Rv	887146
NP_215567.1	CDS	Rv1051c	NC_000962.2	1173945	1174700	R	Rv1051c, (MTV017.04c), len: 251 aa. Conserved hypothetical protein, similar to LLU36837|U36837.1 protein encoded by Lactococcus lactis plasmid pNP40 (298 aa), FASTA scores: opt: 194, E(): 3.5e-06, (30.3% identity in 155 aa overlap). TBparse score is 0.912. Contains possible helix-turn-helix motif at aa 197-218 (Score 1097, +2.92 SD).; hypothetical protein	complement(1173945..1174700)	Mycobacterium tuberculosis H37Rv	887142
NP_215568.1	CDS	Rv1052	NC_000962.2	1175723	1176112	D	Rv1052, (MTV017.05), len: 129 aa. Hypothetical unknown protein.; hypothetical protein	1175723..1176112	Mycobacterium tuberculosis H37Rv	888441
NP_215569.1	CDS	Rv1053c	NC_000962.2	1176011	1176286	R	Rv1053c, (MTV017.06c), len: 91 aa. Hypothetical unknown protein.; hypothetical protein	complement(1176011..1176286)	Mycobacterium tuberculosis H37Rv	887141
NP_215570.2	CDS	Rv1054	NC_000962.2	1176928	1177242	D	Rv1054, (MTV017.07), len: 104 aa. Probable integrase (fragment), similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 aa), FASTA scores: opt: 273, E(): 8.8e-13, (64.7% identity in 68 aa overlap); and to L39071|MSGINT_1 integrase from Mycobacterium paratuberculosis (191 aa), FASTA scores: opt: 105, E(): 0.9, (31.8% identity in 85 aaoverlap). This ORF continues in another frame as Rv1055|MTV017.08 but no error can be found to account for frameshift. Length extended since first submission (+36 aa).; integrase	1176928..1177242	Mycobacterium tuberculosis H37Rv	887139
NP_215571.2	CDS	Rv1055	NC_000962.2	1177239	1177373	D	Rv1055, (MTV017.08), len: 44 aa. Possible integrase (fragment); first 49 aa similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 aa), FASTA scores: opt: 291, E(): 2.2e-16, (74.3% identity in 70 aa overlap); and to L39071|MSGINT_1 integrase from Mycobacterium paratuberculosis (191 aa), FASTA scores: opt: 146, E(): 8.3e-05, (52.1% identity in 48 aa overlap); and to many other integrases or transposases. Shortened since first submission (-34 aa).; hypothetical protein	1177239..1177373	Mycobacterium tuberculosis H37Rv	887138
NP_215572.1	CDS	Rv1056	NC_000962.2	1177628	1178392	D	Rv1056, (MTV017.09), len: 254 aa. Conserved hypothetical protein, some similarity in C-terminal region of Rv0140|MTCI5.14|Z92770 Mycobacterium tuberculosis (126 aa), FASTA scores: opt: 254, E(): 1.2e-10, (43.4% identity in 106 aa overlap); and to Rv1670. C-terminal region is similar to AL035569|SC8D9.02 hypothetical protein from Streptomyces coelicolor (113 aa), FASTA scores: opt: 282, E(): 4.5e-12, (48.0% identity in 100 aa overlap). TBparse score is 0.925.; hypothetical protein	1177628..1178392	Mycobacterium tuberculosis H37Rv	887147
NP_215573.1	CDS	Rv1057	NC_000962.2	1179396	1180577	D	Rv1057, (MTV017.10), len: 393 aa. Conserved hypothetical protein, some similarity to X84710|MMSAG_1 surface antigen of Methanosarcina mazeii (491 aa), FASTA scores: opt: 363, E():6.2e-15, (31.3% identity in 294 aa overlap). TBparse score is 0.892.; hypothetical protein	1179396..1180577	Mycobacterium tuberculosis H37Rv	887135
NP_215574.1	CDS	fadD14	NC_000962.2	1180684	1182315	D	activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase	1180684..1182315	Mycobacterium tuberculosis H37Rv	887133
NP_215575.1	CDS	Rv1059	NC_000962.2	1182391	1183455	D	Rv1059, (MTV017.12), len: 354 aa. Conserved hypothetical protein, similar to Rv0926c|MTCY21C12.20c hypothetical protein from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 338, E(): 1.4e-14, (33.1% identity in 363 aa overlap). TBparse score is 0.909.; hypothetical protein	1182391..1183455	Mycobacterium tuberculosis H37Rv	886015
NP_215576.1	CDS	Rv1060	NC_000962.2	1183508	1183981	D	Rv1060, (MTV017.13), len: 157 aa. Hypothetical unknown protein. TBparse score is 0.912.; hypothetical protein	1183508..1183981	Mycobacterium tuberculosis H37Rv	887130
NP_215577.1	CDS	Rv1061	NC_000962.2	1184015	1184878	D	Rv1061, (MTV017.14), len: 287 aa. Conserved hypothetical protein, similar to hypothetical proteins from various bacteria e.g. D64002|SYCSLRD_75 Synechocystis sp. PCC6803 (304 aa),FASTA scores: opt: 245, E():1.2e-09, (27.1% identity in 258 aa overlap). TBparse score is 0.923.; hypothetical protein	1184015..1184878	Mycobacterium tuberculosis H37Rv	887136
NP_215578.1	CDS	Rv1062	NC_000962.2	1184883	1185740	D	Rv1062, (MTV017.15), len: 285 aa. Conserved hypothetical protein, some similarity to AL079356|SC6G9_10 hypothetical protein in Streptomyces coelicolor (289 aa), FASTA scores: opt: 556, E(): 1.2e-27, (39.0% identity in 287 aa overlap), and Z99111|BSUB0008_176 Bacillus subtilis (260aa), FASTA scores: opt: 163, E(): 0.0013, (27.4% identity in 179aa overlap). TBparse score is 0.902.; hypothetical protein	1184883..1185740	Mycobacterium tuberculosis H37Rv	887129
NP_215579.1	CDS	Rv1063c	NC_000962.2	1185741	1186823	R	Rv1063c, (MTV017.16c), len: 360 aa. Conserved hypothetical protein, similar to P37053|YCHK_ECOLI hypothetical protein from Escherichia coli (314 aa), FASTA scores: opt: 487, E(): 7.2e-23, (32.7% identity in 321 aa overlap). Also partially similar to Rv3239c|MTCY20B11.14c. TBparse score is 0.893. BELONGS TO THE UPF0028 (SWS) FAMILY.; hypothetical protein	complement(1185741..1186823)	Mycobacterium tuberculosis H37Rv	887128
NP_215580.1	CDS	lpqV	NC_000962.2	1186904	1187323	R	Rv1064c, (MTV017.17c), len: 139 aa. Possible lipoprotein LpqV. Has N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.912.; lipoprotein LpqV	complement(1186904..1187323)	Mycobacterium tuberculosis H37Rv	887126
NP_215581.1	CDS	Rv1065	NC_000962.2	1187435	1188001	D	Rv1065, (MTV017.18), len: 188 aa. Conserved hypothetical protein, some similarity to AL0209|SC4H8_11 hypothetical protein from Streptomyces coelicolor (182 aa), FASTA scores: opt: 156, E(): 0.0011, (31.3% identity in 195 aa overlap). TBparse score is 0.921.; hypothetical protein	1187435..1188001	Mycobacterium tuberculosis H37Rv	887125
NP_215582.1	CDS	Rv1066	NC_000962.2	1187998	1188393	D	Rv1066, (MTV017.19), len: 131 aa. Conserved hypothetical protein, strong similarity to AL0209|SC4H8.10 hypothetical protein from Streptomyces coelicolor (132 aa), FASTA scores: opt: 429, E(): 5.2e-23, (57.1% identity in 119 aa overlap). TBparse score is 0.859.; hypothetical protein	1187998..1188393	Mycobacterium tuberculosis H37Rv	887127
YP_177780.1	CDS	PE_PGRS19	NC_000962.2	1188421	1190424	R	Rv1067c, (MTV017.20c), len: 667 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). Similar to Rv3388|MTV004.46 M. tuberculosis (731 aa), FASTA scores: opt: 2227, E(): 0, (55.6% identity in 710 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1, probably fortuitous. TBparse score is 0.837.; PE-PGRS family protein	complement(1188421..1190424)	Mycobacterium tuberculosis H37Rv	887122
YP_177781.1	CDS	PE_PGRS20	NC_000962.2	1190757	1192148	R	Rv1068c, (MTV017.21c), len: 463 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). Similar to AL021897|MTV017_19 Mycobacterium tuberculosis H37Rv (667 aa), FASTA scores: opt: 1875, E(): 0, (55.0% identity in 667 aa overlap). TBparse score is 0.849.; PE-PGRS family protein	complement(1190757..1192148)	Mycobacterium tuberculosis H37Rv	887123
NP_215585.1	CDS	Rv1069c	NC_000962.2	1192510	1194273	R	Rv1069c, (MTV017.22c), len: 587 aa. Conserved hypothetical protein, hydrophobic regions in N-terminal domain. Similar in part to O07136|B1306.04C B1306.04c protein from Mycobacterium leprae (89 aa), FASTA scores: opt: 229, E(): 1.3e-07, (54.2% identity in 72 aa overlap). TBparse score is 0.907.; hypothetical protein	complement(1192510..1194273)	Mycobacterium tuberculosis H37Rv	887120
NP_215586.1	CDS	echA8	NC_000962.2	1194270	1195043	R	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	complement(1194270..1195043)	Mycobacterium tuberculosis H37Rv	887117
NP_215587.1	CDS	echA9	NC_000962.2	1195055	1196092	R	catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase	complement(1195055..1196092)	Mycobacterium tuberculosis H37Rv	887116
NP_215588.1	CDS	Rv1072	NC_000962.2	1196279	1197115	D	Rv1072, (MTV017.25), len: 278 aa. Probable conserved transmembrane protein, equivalent to O07139|B1306.07|Y13803 Protein B1306.07 from Mycobacterium leprae (220 aa), FASTA scores: opt:1032, E(): 0, (75.0% identity in 220 aa overlap); and at the C-terminal end to Q50056|U1740D Mycobacterium leprae (96 aa), FASTA scores: opt: 381, E(): 1.2e-18, (71.6% identity in 81 aa overlap). Similar to Q54192|M80628|STMBLDA_1 TRANSFER RNA-LEU (BLDA) GENE AND ORF from Streptomyces griseus (293 aa), FASTA scores: opt:558, E(): 4.7e-30, (41.5% identity in 299 aa overlap). TBparse score is 0.896.; transmembrane protein	1196279..1197115	Mycobacterium tuberculosis H37Rv	887114
NP_215589.1	CDS	Rv1073	NC_000962.2	1197231	1198082	D	Rv1073, (MTV017.26), len: 283 aa. Conserved hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. Rv1482c|Z79701|MTCY277.03 Mycobacterium tuberculosis (339 aa), FASTA scores: opt: 810, E(): 0, (47.4% identity in 272 aa overlap); Rv3555c|Z92774|MTCY6G11_2 Mycobacterium tuberculosis (289 aa), FASTA scores: opt: 704, E(): 0, (44.4% identity in 259 aa overlap); and Rv3517, etc., and GIR10|AF002133_10 Mycobacterium avium strain GIR10 (346 aa), FASTA scores: opt: 802, E(): 0, (48.1% identity in 270 aa overlap). TBparse score is 0.942.; hypothetical protein	1197231..1198082	Mycobacterium tuberculosis H37Rv	887132
NP_215590.1	CDS	fadA3	NC_000962.2	1198156	1199373	R	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase	complement(1198156..1199373)	Mycobacterium tuberculosis H37Rv	887113
NP_215591.1	CDS	Rv1075c	NC_000962.2	1199426	1200370	R	Rv1075c, (MTV017.28c), len: 314 aa. Possibly exported protein, as it contains a N-terminal signal sequence, hydrophobic domain from aa 7-25. Similar to U15183|MLU15183_2 Mycobacterium leprae cosmid B1740 (106 aa), FASTA scores: opt: 207, E(): 1.6e-06, (42.6% identity in 101 aa overlap). Also weak similarity to many glyceraldehyde-3-phosphate dehydrogenases e.g. Q41595|G3PC_TAXBA Taxus baccata (340 aa), FASTA scores: opt: 147, E(): 0.027, (27.5% identity in 189 aa overlap). TBparse score is 0.916.; hypothetical protein	complement(1199426..1200370)	Mycobacterium tuberculosis H37Rv	887110
NP_215592.1	CDS	lipU	NC_000962.2	1200767	1201660	D	Rv1076, (MTV017.29), len: 297 aa. Possible lipU, lipase (EC 3.1.-.-), very similar to several Mycobacterium tuberculosis proteins e.g. Z95390|Rv3487c|MTCY13E12.41c (277 aa), FASTA scores: opt: 1225, E(): 0, (76.0% identity in 246 aa overlap); Rv1426c, etc. Also similar to esterases and lipases of around 300 aa e.g. Q44087 ESTERASE PRECURSOR from Acinetobacter lwoffii esterase (303), FASTA scores: opt: 427, E(): 1.9e-21, (32.5% identity in 280 aa overlap). Equivalent to AL035159|MLCB1450 _7 Mycobacterium leprae (335 aa), FASTA scores: opt: 1588, E(): 0, (79.7% identity in 296 aa overlap). TBparse score is 0.935.; lipase LipU	1200767..1201660	Mycobacterium tuberculosis H37Rv	887112
YP_177782.1	CDS	cbs	NC_000962.2	1201717	1203111	D	Rv1077, (MTV017.30), len: 464 aa. Probable cbs (previously cysM2), cystathionine beta-synthase (EC 4.2.1.22), similar throughout its length to many eukaryotic cystathionine beta-synthases e.g. P32232|CBS_RAT CYSTATHIONINE BETA-SYNTHASE (560 aa), FASTA scores: opt: 951, E(): 0, (40.2% identity in 450 aa overlap); also similar in N-terminal domain (aa 1 - 330) to Rv2334|MTCY98.03 CysK Mycobacterium tuberculosis (310 aa), FASTA scores: opt: 855, E(): 0, (46.8% identity in 314 overlap); and other cysteine synthase proteins e.g. Rv1336, Rv0848, etc. Contains PS00217 Sugar transport proteins signature 2 probably spurious. TBparse score is 0.891. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY.; cysM2; cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (hemoprotein H-450)	1201717..1203111	Mycobacterium tuberculosis H37Rv	887108
NP_215594.1	CDS	pra	NC_000962.2	1203313	1204035	D	Rv1078, (MTV017.31), len: 240 aa. Probable pra, Proline-rich antigen homolog, equivalent to X65546|MLPRAG_1 proline rich antigen from Mycobacterium leprae (249 aa), FASTA scores: opt: 1162, E(): 3.3e-30, (64.8% identity in 253 aa overlap). Has potential hydrophobic domains. TBparse score is 0.929.; proline-rich antigen	1203313..1204035	Mycobacterium tuberculosis H37Rv	887111
NP_215595.1	CDS	metB	NC_000962.2	1204067	1205233	D	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase	1204067..1205233	Mycobacterium tuberculosis H37Rv	887103
NP_215596.1	CDS	greA	NC_000962.2	1205304	1205798	R	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA	complement(1205304..1205798)	Mycobacterium tuberculosis H37Rv	887115
NP_215597.1	CDS	Rv1081c	NC_000962.2	1205984	1206418	R	Rv1081c, (MTV017.34c), len: 144 aa. Probable conserved membrane protein, with hydrophobic stretch from aa 26 - 48, highly similar to NP_302548.1|NC_002677 conserved membrane protein from Mycobacterium leprae. TBparse score is 0.906.; hypothetical protein	complement(1205984..1206418)	Mycobacterium tuberculosis H37Rv	887102
NP_215598.1	CDS	mca	NC_000962.2	1206520	1207386	D	Rv1082, (MTV017.35), len: 288 aa. mca, mycothiol conjugate amidase (see citation below), equivalent to NP_302547.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (290 aa), FASTA scores: opt: 1737, E(): 0, (86.4% identity in 287 aa overlap); and similar to Q54358|X79146 lmbE protein from Streptomyces lincolnensis (270 aa). Also similar to Rv1170|MTV005.06|MSHB GlcNAc-Ins deacetylase from Mycobacterium tuberculosis (303 aa), FASTA scores: opt: 411, E(): 9.4e-20, (35.8% identity in 299 aa overlap). TBparse score is 0.896.; Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase)	1206520..1207386	Mycobacterium tuberculosis H37Rv	887101
NP_215599.1	CDS	Rv1083	NC_000962.2	1207383	1207649	D	Rv1083, (MTV017.36), len: 88 aa. Conserved hypothetical protein, similar to U15183|MLU15183_9 hypothetical protein from Mycobacterium leprae (167 aa), FASTA scores: opt: 332, E(): 1.2e-13, (58.4% identity in 101 aa overlap). Hydrophobic domain aa 25-43. TBparse score is 0.905.; hypothetical protein	1207383..1207649	Mycobacterium tuberculosis H37Rv	887100
NP_215600.1	CDS	Rv1084	NC_000962.2	1207636	1209657	D	Rv1084, (MTV017.37), len: 673 aa. Conserved hypothetical protein, similar to P37512|YYAL_BACSU hypothetical protein from Bacillus subtilis (689 aa), FASTA scores: opt: 1063, E() : 0, (36.5% identity in 696 aa overlap); AE0009|AE000983_10 Archaeoglobus fulgidus section 1 (642 aa), FASTA scores: opt: 1018, E(): 0, (37.2% identity in 600 aa overlap). Also similar to AE001938|AE001938_9 Deinococcus radiodurans (690 aa), FASTA scores: opt: 1097, E(): 0, (41.6% identity in 694 aa overlap). TBparse score is 0.872.; hypothetical protein	1207636..1209657	Mycobacterium tuberculosis H37Rv	887098
NP_215601.1	CDS	Rv1085c	NC_000962.2	1209756	1210484	R	Rv1085c, (MTV017.38c), len: 242 aa. Possible hemolysin-like protein, integral membrane protein, similar to many hemolysins, and hypothetical proteins e.g. U28375|ECU28375_49 Hypothetical protein from Escherichia coli (219 aa), FASTA scores: opt: 308, E(): 7.5e-15, (30.6% identity in 180 aa overlap); AE0011|HIAE001124_2 Hypothetical protein from Borrelia burgdorferi (233 aa), FASTA scores: opt: 305, E(): 1.3e-14, (25.6% identity in 203 aa overlap). Also weakly similar to HLY3_BACCE|P54176 haemolysin from Bacillus cereus (219 aa), FASTA scores: opt: 247, E(): 8.7e-12, (27.5% identity in 171 aa overlap). Also similar to AE002027|AE002027_8 probable hemolysin from Deinococcus radiodurans (219 aa), FASTA scores: opt: 354, E(): 1.8e-16, (31.1% identity in 219 aa overlap). TBparse score is 0.884.; hemolysin-like protein	complement(1209756..1210484)	Mycobacterium tuberculosis H37Rv	887107
NP_215602.1	CDS	Rv1086	NC_000962.2	1210595	1211383	D	Rv1086, (MTV017.39), len: 262 aa. Short (C15) chain Z-isoprenyl diphosphate synthase (EC 2.5.1.10) (see citations below), equivalent to NP_302598.1|NC_002677 possible undecaprenyl pyrophosphate synthetase from Mycobacterium leprae (262 aa), similar to many hypothetical proteins and several potential members of the upp synthase family e.g. NP_296167.1|NC_001263 undecaprenyl diphosphate synthase from Deinococcus radiodurans (339 aa); P20182|YT14_STRFR Hypothetical protein from Streptomyces fradiae (259 aa), FASTA scores: opt: 840, E(): 0, (51.0% identity in 259 aa overlap); and P38118|YARF_CORGL Hypothetical protein from Corynebacterium glutamicicum (234 aa), FASTA scores: opt: 729, E(): 0, (56.0% identity in 209 aa overlap); etc. Also similar to Rv2361c|MTCY27.19 (296 aa) (35.6% identity in 233 aa overlap). Contains PS01066 Uncharacterized protein family UPF0015 signature. SEEMS TO BELONG TO THE UPP SYNTHETASE FAMILY.; short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate synthetase) (geranyltranstransferase) (farnesyl pyrophosphate synthetase)	1210595..1211383	Mycobacterium tuberculosis H37Rv	887097
YP_177783.1	CDS	PE_PGRS21	NC_000962.2	1211560	1213863	D	Rv1087, (MTV017.40), len: 767 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Similar to Rv1090|AL021897|MTV017_43 Mycobacterium tuberculosis H37Rv (853 aa), FASTA scores: opt: 2819, E(): 0, (59.8% identity in 860 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1 near C -terminus. TBparse score is 0.859.; PE-PGRS family protein	1211560..1213863	Mycobacterium tuberculosis H37Rv	887094
YP_177637.1	CDS	Rv1087A	NC_000962.2	1214040	1214360	D	Rv1087A, 106 aa (fragment). Conserved hypothetical protein, highly similar to C-terminus of near ORF O53434|YA86_MYCTU|Rv1086|MT1118|MTV017.39 SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE from Mycobacterium tuberculosis (262 aa), FASTA scores: opt: 200, E(): 1.1e-06, (57.9% identity in 76 aa overlap).; hypothetical protein	1214040..1214360	Mycobacterium tuberculosis H37Rv	3205067
YP_177784.1	CDS	PE9	NC_000962.2	1214513	1214947	D	Rv1088, (MTV017.41), len: 144 aa. Member of Mycobacterium tuberculosis PE family (see citation below), similar to many others e.g. Z96071|MTCI418B_6 Mycobacterium tuberculosis cosmid (487 aa), FASTA scores: opt: 318, E(): 7.3e-14, (60.9% identity in 87 aa overlap) - except it appears to be frameshifted around codon 84. No error to account for frameshift could be found. TBparse score is 0.943; PE family protein	1214513..1214947	Mycobacterium tuberculosis H37Rv	887096
YP_177785.1	CDS	PE10	NC_000962.2	<1214769	1215131	D	Rv1089, (MTV017.42), len: 120 aa. Member of the Mycobacterium tuberculosis PE family of glycine-rich proteins (see citation below). Partial ORF that appears to be frameshifted continuation of Rv1088|MTV017.41. Sequence has been checked and appears correct. Similar to Z95555|MTCY06F7_4 Mycobacterium tuberculosis cosmid (401 aa), FASTA scores: opt:126, E(): 2, (29.6% identity in 125 aa overlap).; PE family protein	<1214769..1215131	Mycobacterium tuberculosis H37Rv	887090
YP_177638.1	CDS	celA2a	NC_000962.2	1215517	1215621	D	Rv1089A, len: 34 aa. Probable celA2a, first part of cellulase (endoglucanase) (EC 3.2.1.4), similar to N-terminus of others.; endo-1,4-beta-glucanase	1215517..1215621	Mycobacterium tuberculosis H37Rv	3205066
NP_215606.1	CDS	celA2b	NC_000962.2	1215599	1216054	D	Rv1090, (MTV017.43), len: 151 aa. Probable celA2b, second part of cellulase (endoglucanase) (EC 3.2.1.4), similar to C-terminus of others e.g. O08468 cellulase CEL2 from Streptomyces halstedi (377 aa), FASTA scores: opt: 554, E(): 1.2e-30, (52.0% identity in 152 aa overlap); etc. TBparse score is 0.876. Gene appears to have been inactivated by frameshift mutations but no errors could be found that would account for this.; endo-1,4-beta-glucanase	1215599..1216054	Mycobacterium tuberculosis H37Rv	885637
YP_177786.1	CDS	PE_PGRS22	NC_000962.2	1216469	1219030	D	Rv1091, (MTV017.44), len: 853 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Similar to Rv1087|AL021897|MTV017_39 Mycobacterium tuberculosis H37Rv (767 aa), FASTA scores: opt: 2819, E(): 0, (60.0% identity in 860 aa overlap). TBparse score is 0.859.; PE-PGRS family protein	1216469..1219030	Mycobacterium tuberculosis H37Rv	885258
NP_215608.1	CDS	coaA	NC_000962.2	1219248	1220186	R	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase	complement(1219248..1220186)	Mycobacterium tuberculosis H37Rv	885120
YP_177787.1	CDS	glyA	NC_000962.2	1220574	1221854	D	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase	1220574..1221854	Mycobacterium tuberculosis H37Rv	885338
NP_215610.1	CDS	desA2	NC_000962.2	1221959	1222786	D	Rv1094, (MTV017.47), len: 275 aa. Possible desA2, acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.99.6), equivalent to AL049491|MLCB1222_15 from Mycobacterium leprae (275 aa), FASTA score: (78.1% identity in 274 aa overlap). Also weakly similar to plant stearoyl-acyl carrier protein desaturases, and very similar to U49839|MTV043.16C|Rv0824c enzyme desA1 from Mycobacterium tuberculosis (338 aa), FASTA scores: opt: 525, E(): 8.5e-30, (32.2% identity in 270 aa overlap); and to U15182|MLU15182_32 acyl-carrier protein desaturase precursor from Mycobacterium leprae (338 aa), FASTA scores: opt: 506, E(): 1.9e-28, (34.1% identity in 261 aa overlap). TBparse score is 0.894.; acyl-[acyl-carrier protein] desaturase	1221959..1222786	Mycobacterium tuberculosis H37Rv	885339
NP_215611.1	CDS	phoH2	NC_000962.2	1222997	1224298	D	Rv1095, (MTV017.48), len: 433 aa. Probable phoH2, phoH-like protein (phosphate starvation-induced protein), probably ATP-binding protein. Equivalent to AL049491 MLCB1222_14 Mycobacterium leprae (433 aa) (92.8% identity in 432 aa overlap). Similar to many proteins described as PhoH-like e.g. Z97025|BSZ97025_12 Bacillus subtilis (442 aa), FASTA scores: opt: 605, E(): 0, (40.1% identity in 444 aa overlap); or Mycobacterium tuberculosis Rv2368c|O05830|PHOL_MYCTU Mycobacterium tuberculosis (352 aa), FASTA scores: opt: 390, E(): 4e-19, (31.5% identity in 241 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.885. BELONGS TO THE PHOH FAMILY.; PhoH-like protein PhoH2 (phosphate starvation-inducible protein PsiH)	1222997..1224298	Mycobacterium tuberculosis H37Rv	885592
NP_215612.1	CDS	Rv1096	NC_000962.2	1224385	1225260	D	Rv1096, (MTV017.49), len: 291 aa. Possible glycosyl hydrolase (EC 3.-.-.-), possibly deacetylase or esterase. Equivalent to AL049491|MLCB1222_13 Mycobacterium leprae (291 aa) (81.3% identity in 289 aa overlap). Similar at the C-terminus to enzymes involved in carbohydrate degradation including Z99110|BSUB0007_92 endo-1,4-beta-xylanase homolog yjeA from Bacillus subtilis (467 aa), FASTA scores: opt: 418, E(): 2.6e-17, (38.6% identity in 184 aa overlap); M64552|STMXLNB_2 acetyl-xylan esterase from Streptomyces lividans (335 aa), FASTA scores: opt: 371, E(): 1.1e-14, (31.6% identity in 237 aa overlap); NP_345933.1|NC_003028 peptidoglycan N-acetylglucosamine deacetylase A from Streptococcus pneumoniae (463 aa); etc. Has possible N-terminal signal sequence with TMhelix at aa 13-31. TBparse score is 0.905.; glycosyl hydrolase	1224385..1225260	Mycobacterium tuberculosis H37Rv	885949
NP_215613.1	CDS	Rv1097c	NC_000962.2	1225263	1226144	R	Rv1097c, (MTV017.50c), len: 293 aa. Probable membrane Gly-, Pro-rich protein, similar to Mycobacterium tuberculosis Rv2507|MTCY07A7. 13|Z95556 (273 aa), FASTA scores: opt: 219, E(): 0.023, (30.5% identity in 266 aa overlap); and Rv2507. Contains potential membrane spanning region (aa 68-92). TBparse score is 0.912.; hypothetical protein	complement(1225263..1226144)	Mycobacterium tuberculosis H37Rv	885962
NP_215614.1	CDS	fumC	NC_000962.2	1226141	1227565	R	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase	complement(1226141..1227565)	Mycobacterium tuberculosis H37Rv	885651
NP_215615.1	CDS	glpX	NC_000962.2	1227596	1228582	R	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II	complement(1227596..1228582)	Mycobacterium tuberculosis H37Rv	885861
NP_215616.1	CDS	Rv1100	NC_000962.2	1228683	1229384	D	Rv1100, (MTV017.53), len: 233 aa. Conserved hypothetical protein, slightly similar to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 122, E(): 6.9, (27.4% identity in 135 aa overlap). Equivalent to AL049491|MLCB1222_9 Mycobacterium leprae (257 aa) (63.8% identity in 257 aa overlap). TBparse score is 0.914.; hypothetical protein	1228683..1229384	Mycobacterium tuberculosis H37Rv	885852
NP_215617.1	CDS	Rv1101c	NC_000962.2	1229391	1230548	R	Rv1101c, (MTV017.54c), len: 385 aa. Conserved membrane protein, shows some similarity to other bacterial proteins e.g. P77406|PERM_ECOLI PUTATIVE PERMEASE PERM from Escherichia coli (353 aa), FASTA scores: opt: 287, E(): 8.8e-12, (24.9% identity in 349 aa overlap). TBparse score is 0.886.; hypothetical protein	complement(1229391..1230548)	Mycobacterium tuberculosis H37Rv	885482
NP_215618.1	CDS	Rv1102c	NC_000962.2	1230660	1230971	R	Rv1102c, (MTV017.55c), len: 103 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protens e.g. Rv1942c|MTCY9F9_22 (109 aa), FASTA scores: opt: 158, E(): 3.6e-05, (33.3% identity in 93 aa overlap); Rv0659c|MTCI376_17 (102aa), opt: 140, E(): 0.00072, (40.6% identity in 69aa overlap); and Rv1495. TBparse score is 0.924.; hypothetical protein	complement(1230660..1230971)	Mycobacterium tuberculosis H37Rv	886001
NP_215619.1	CDS	Rv1103c	NC_000962.2	1230971	1231291	R	Rv1103c, (MTV017.56c), len: 106 aa. Conserved hypothetical protein, similar to part of Mycobacterium tuberculosis hypothetical protein Rv2472|AL021246|MTV008_27 Mycobacterium tuberculosis (97 aa), FASTA score: opt: 135, E(): 0.0091, (45.8% identity in 72 aa overlap). TBparse score is 0.916.; hypothetical protein	complement(1230971..1231291)	Mycobacterium tuberculosis H37Rv	885941
NP_215620.1	CDS	Rv1104	NC_000962.2	1231301	1231990	D	Rv1104, (MTV017.57), len: 229 aa. Possible para-nitrobenzyl esterase (fragment; possibly first part) (EC 3.1.1.-). Similar to the N-terminal domain of many e.g. P37967|PNBA_BACSU Bacillus subtilis (489 aa), FASTA scores: opt: 715, E(): 0, (53.4% identity in 191 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing in MTV017.58|Rv1105. TBparse score is 0.934.; hypothetical protein	1231301..1231990	Mycobacterium tuberculosis H37Rv	885835
NP_215621.2	CDS	Rv1105	NC_000962.2	1232311	1232826	D	Rv1105, (MTV017.58), len: 171 aa. Possible para-nitrobenzyl esterase (fragment; possibly second part) (EC 3.1.1.-). Similar to C-terminal domain of many e.g. P71048 PARA-NITROBENZYL ESTERASE from Bacillus subtilis (489 aa), FASTA scores: opt: 248, E(): 2.7e-10, (32.3% identity in 167 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing from MTV017.57|Rv1104. Start changed since first submission. TBparse score is 0.936.; hypothetical protein	1232311..1232826	Mycobacterium tuberculosis H37Rv	885977
NP_215622.1	CDS	Rv1106c	NC_000962.2	1232844	1233956	R	Rv1106c, (MTV017.59c), len: 370 aa. Probable cholesterol dehydrogenase (EC 1.1.1.-). Equivalent to AL049491|MLCB1222_7 Mycobacterium leprae (376 aa ) (75.5% identity in 375 aa overlap). Highly similar to Q03704 NAD(P)-dependent cholesterol dehydrogenase from Nocardia sp. (364 aa), FASTA scores: opt: 1789, E(): 0, (74.5% identity in 361 aa overlap). Also similar to U32426|MCU32426_1 3-beta-hydroxy-Delta5-steroid dehydrogenase from Molluscum contagiosum virus (354 aa), FASTA scores: opt: 432, E(): 1.7e-22, (34.6% identity in 347 aa overlap). Also similar to series of Mycobacterium tuberculosis hypothetical proteins described as sugar epimerases or dehydratases e.g. Rv3634c, Rv3784, Rv3464, etc. TBparse score is 0.885. The transcription of this CDS seems to be activated specifically in host granulomas (see Ramakrishnan et al., 2000).; cholesterol dehydrogenase	complement(1232844..1233956)	Mycobacterium tuberculosis H37Rv	886004
NP_215623.1	CDS	xseB	NC_000962.2	1233966	1234223	R	catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit	complement(1233966..1234223)	Mycobacterium tuberculosis H37Rv	886005
NP_215624.1	CDS	xseA	NC_000962.2	1234213	1235460	R	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit	complement(1234213..1235460)	Mycobacterium tuberculosis H37Rv	885984
NP_215625.1	CDS	Rv1109c	NC_000962.2	1235457	1236095	R	Rv1109c, (MTV017.62c), len: 212 aa. Conserved hypothetical protein. Equivalent to AL049491|MLCB1222_4 hypothetical protein from Mycobacterium leprae (205 aa) (68.1% identity in 213 aa overlap). TBparse score is 0.905.; hypothetical protein	complement(1235457..1236095)	Mycobacterium tuberculosis H37Rv	885828
YP_177788.1	CDS	ispH	NC_000962.2	1236185	1237192	D	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase	1236185..1237192	Mycobacterium tuberculosis H37Rv	885830
NP_215627.2	CDS	Rv1111c	NC_000962.2	1237209	1238192	R	Rv1111c, (MTV017.64c), len: 327 aa. Conserved hypothetical protein, N-terminal domain is hydrophobic, C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. TBparse score is 0.934.; hypothetical protein	complement(1237209..1238192)	Mycobacterium tuberculosis H37Rv	885447
NP_215628.1	CDS	ychF	NC_000962.2	1238255	1239328	D	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD	1238255..1239328	Mycobacterium tuberculosis H37Rv	887151
NP_215629.1	CDS	Rv1113	NC_000962.2	1239416	1239613	D	Rv1113, (MTCY22G8.02), len: 65 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv2758c|AL00896 7|MTV002.23 (88 aa) FASTA scores: opt: 97, E(): 0.86, (33.3% identity in 69 aa overlap). Part of family including Rv2871, Rv1241, Rv2132, Rv3321c, etc.; hypothetical protein	1239416..1239613	Mycobacterium tuberculosis H37Rv	885450
NP_215630.1	CDS	Rv1114	NC_000962.2	1239610	1239984	D	Rv1114, (MTCY22G8.03), len: 124 aa. Conserved hypothetical protein, slight similarity to Mycobacterium tuberculosis hypothetical proteins MTCY159.08c (33.0% identity in 115 aa overlap); Rv1561 and Rv2010.; hypothetical protein	1239610..1239984	Mycobacterium tuberculosis H37Rv	885490
NP_215631.1	CDS	Rv1115	NC_000962.2	1240187	1240885	D	Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence.; hypothetical protein	1240187..1240885	Mycobacterium tuberculosis H37Rv	885951
NP_215632.1	CDS	Rv1116	NC_000962.2	1241003	1241188	D	Rv1116, (MTCY22G8.05), len: 61 aa. Hypothetical unknown protein.; hypothetical protein	1241003..1241188	Mycobacterium tuberculosis H37Rv	885969
YP_177639.1	CDS	Rv1116A	NC_000962.2	1241115	1241390	R	Rv1116A, len: 91 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of Rv1646|Z85982_9 from Mycobacterium tuberculosis (310 aa), FASTA scores: opt: 301, E(): 9.3e-13, (68.05% identity in 72 aa overlap). Also overlaps gene on other strand, Rv1116, at 3'-end.; hypothetical protein	complement(1241115..1241390)	Mycobacterium tuberculosis H37Rv	3205101
NP_215633.1	CDS	Rv1117	NC_000962.2	1241633	1241956	D	Rv1117, (MTCY22G8.06), len: 107 aa. Conserved hypothetical protein, some similarity to P94425|D50453 hypothetical protein from Bacillus subtilis (95 aa), fasta scores: opt: 128, E(): 5.1e-06, (28.3% identity in 92 aa overlap); and AL117322|SCF1.02 Streptomyces coelicolor (109 aa), FASTA scores: opt: 437, E(): 1.6e-25, (57.5% identity in 106 aa overlap).; hypothetical protein	1241633..1241956	Mycobacterium tuberculosis H37Rv	885847
NP_215634.1	CDS	Rv1118c	NC_000962.2	1241971	1242831	R	Rv1118c, (MTCY22G8.07c), len: 286 aa. Conserved hypothetical protein, similar to pseudogene ML0942 in Mycobacterium leprae.; hypothetical protein	complement(1241971..1242831)	Mycobacterium tuberculosis H37Rv	888936
NP_215635.1	CDS	Rv1119c	NC_000962.2	1242864	1243013	R	Rv1119c, (MTCY22G8.08c), len: 49 aa. Hypothetical unknown protein.; hypothetical protein	complement(1242864..1243013)	Mycobacterium tuberculosis H37Rv	885853
NP_215636.1	CDS	Rv1120c	NC_000962.2	1243010	1243504	R	Rv1120c, (MTCY22G8.09c), len: 164 aa. Conserved hypothetical protein, some similarity at C-terminus to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1890c|MTCY180.28 (462 aa), FASTA scores: opt: 187, E(): 2.2e-05, (36.6% identity in 93 aa overlap) and Rv2488c|YZ19_MYCTU|Q10551 (285 aa), FASTA scores: opt: 156, E(): 0.00074, (32.7% identity in 107 aa overlap).; hypothetical protein	complement(1243010..1243504)	Mycobacterium tuberculosis H37Rv	885633
YP_177789.1	CDS	zwf1	NC_000962.2	1243707	1245107	D	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase	1243707..1245107	Mycobacterium tuberculosis H37Rv	885817
NP_215638.1	CDS	gnd2	NC_000962.2	1245129	1246151	D	similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase-like protein	1245129..1246151	Mycobacterium tuberculosis H37Rv	885820
NP_215639.1	CDS	bpoB	NC_000962.2	1246144	1247052	R	Rv1123c, (MTCY22G8.12c), len: 302 aa. Possible bpoB, peroxidase (non-haem peroxidase) (EC 1.11.1.-), with some similarity to a range of enzymes from several organisms including: DEH1_MORSP|Q01398 haloacetate dehalogenase (EC 3.8.1.3) from Moraxella sp. (294 aa), FASTA scores: opt: 201, E(): 2.1e-06, (35.8% identity in 134 aa overlap); and BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 (EC 1.11.1.-) from Streptomyces aureofaciens (274 aa), FASTA scores: opt: 187, E(): 1.6e-05, (23.1% identity in 281 aa overlap). Similar to several other Mycobacterium tuberculosis proteins, probable epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3473c, Rv3171c, etc. Contains PS00216 Sugar transport proteins signature 1.; peroxidase BpoB	complement(1246144..1247052)	Mycobacterium tuberculosis H37Rv	885965
NP_215640.1	CDS	ephC	NC_000962.2	1247127	1248077	D	Rv1124, (MTCY22G8.13), len: 316 aa. Probable ephC, epoxide hydrolase (EC 3.3.2.3) (see citation below), similar to Q42566 epoxide hydrolase from Arabidopsis thaliana (321 aa), FASTA scores: opt: 298, E(): 8.2e-13, (27.6% identity in 333 aa overlap). Similar to other M. tuberculosis epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3670, Rv3473c, etc.; epoxide hydrolase EphC	1247127..1248077	Mycobacterium tuberculosis H37Rv	886022
NP_215641.1	CDS	Rv1125	NC_000962.2	1248082	1249326	D	Rv1125, (MTCY22G8.14), len: 414 aa. Conserved hypothetical protein. Similar to AL133278|SCM11.13 hypothetical protein from Streptomyces coelicolor (446 aa), FASTA scores: opt: 182, E(): 0.0005, (28.1% identity in 437 aa overlap).; hypothetical protein	1248082..1249326	Mycobacterium tuberculosis H37Rv	886021
NP_215642.1	CDS	Rv1126c	NC_000962.2	1249330	1249935	R	Rv1126c, (MTCY22G8.15c), len: 201 aa. Conserved hypothetical protein, similar in N-terminus to O05567|MLCB33.17 hypothetical protein from Mycobacterium leprae (141 aa), FASTA scores: opt: 332, E(): 1.4e-23, (58.4% identity in 101 aa overlap).; hypothetical protein	complement(1249330..1249935)	Mycobacterium tuberculosis H37Rv	885845
NP_215643.1	CDS	ppdK	NC_000962.2	1249932	1251404	R	catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase	complement(1249932..1251404)	Mycobacterium tuberculosis H37Rv	885956
NP_215644.1	CDS	Rv1128c	NC_000962.2	1251617	1252972	R	Rv1128c, (MTCY22G8.17c), len: 451 aa. Conserved hypothetical protein, in REP13E12 degenerate repeat, highly similar to several Mycobacterium tuberculosis proteins in REP13E12 repeats e.g. Rv1148c, Rv1945, Rv3467, etc.; hypothetical protein	complement(1251617..1252972)	Mycobacterium tuberculosis H37Rv	885849
NP_215645.1	CDS	Rv1129c	NC_000962.2	1253074	1254534	R	Rv1129c, (MTCY22G8.18c), len: 486 aa. Possible transcriptional regulator protein, similar to Rv0465c|MTV038.09c Mycobacterium tuberculosis (474 aa), FASTA scores: E(): 0, (47.4% identity in 468 aa overlap). Helix turn helix motif present from aa 32-53.; transcriptional regulator protein	complement(1253074..1254534)	Mycobacterium tuberculosis H37Rv	885963
NP_215646.1	CDS	Rv1130	NC_000962.2	1254555	1256135	D	Rv1130, (MTCY22G8.19), len: 526 aa. Conserved hypothetical protein, some similarity to AP000063|AP000063_192 hypothetical protein from Aeropyrum pernix (479 aa), FASTA scores: opt: 717, E(): 0, (34.3% identity in 443 a a overlap), and to PRPD_ECOLI|P77243 prpd protein from Escherichia coli (483aa), FASTA scores: opt: 234, E(): 3.3e-08, (27.0% identity in 429 aa overlap).; hypothetical protein	1254555..1256135	Mycobacterium tuberculosis H37Rv	885843
NP_215647.1	CDS	gltA1	NC_000962.2	1256132	1257313	D	catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase	1256132..1257313	Mycobacterium tuberculosis H37Rv	888949
NP_215648.1	CDS	Rv1132	NC_000962.2	1257325	1259055	D	Rv1132, (MTCY22G8.21), len: 576 aa. Conserved membrane protein, similar to O06827|Rv1431|MTCY493.23C membrane protein from Mycobacterium tuberculosis (589 aa), fasta scores: opt: 1811, E(): 0, (48.2% identity in 585 aa overlap).; hypothetical protein	1257325..1259055	Mycobacterium tuberculosis H37Rv	885824
NP_215649.1	CDS	metE	NC_000962.2	1259067	1261346	R	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	complement(1259067..1261346)	Mycobacterium tuberculosis H37Rv	888947
NP_215650.1	CDS	Rv1134	NC_000962.2	1261922	1262158	D	Rv1134, (MTCI65.01), len: 78 aa. Hypothetical unknown protein. TBparse score is 0.838.; hypothetical protein	1261922..1262158	Mycobacterium tuberculosis H37Rv	885983
YP_177790.1	CDS	PPE16	NC_000962.2	1262272	1264128	R	Rv1135c, (MTCI65.02c), len: 618 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to Rv2356c (59.6% identity in 627 aa overlap); etc.. TBparse score is 0.881.; PPE family protein	complement(1262272..1264128)	Mycobacterium tuberculosis H37Rv	885131
YP_177640.1	CDS	Rv1135A	NC_000962.2	1264314	1264556	D	Rv1135A, len: 80 aa. Possible acetyl-CoA acetyltransferase (EC 2.3.1.9) (possible gene fragment), highly similar to other acetyl-CoA acetyltransferases e.g. C-terminal part of Rv3556c|Z92774|MTCY6G11_2|MTCY06G11.03|fadA6 ACETYL-COA ACETYLTRANSFERASE from Mycobacterium tuberculosis (386 aa), FASTA scores: opt: 219, E(): 5.7e-09, (63.6% identity in 55 aa overlap).; acetyl-CoA acetyltransferase	1264314..1264556	Mycobacterium tuberculosis H37Rv	3205047
NP_215652.1	CDS	Rv1136	NC_000962.2	1264606	1264947	D	Rv1136, (MTCI65.03), len: 113 aa. Probable enoyl-CoA hydratase (possible gene fragment) (EC 5.-.-.-). Some similarity to N-terminus of carnitine racemases and enoyl-CoA hydratases (but much shorter) e.g. I41014 carnitine racemase from Escherichia coli (297 aa), FASTA scores: opt: 258, E(): 2.5e-11, (44.5% identity in 110 aa overlap); and Rv0222 putative enoyl-CoA hydratase from M. tuberculosis (262 aa). TBparse score is 0.871.; enoyl-CoA hydratase	1264606..1264947	Mycobacterium tuberculosis H37Rv	888948
NP_215653.1	CDS	Rv1137c	NC_000962.2	1265087	1265455	R	Rv1137c, (MTCI65.04c), len: 122 aa. Hypothetical unknown protein.; hypothetical protein	complement(1265087..1265455)	Mycobacterium tuberculosis H37Rv	885071
NP_215654.1	CDS	Rv1138c	NC_000962.2	1265472	1266488	R	Rv1138c, (MTCI65.05c), len: 338 aa. Possible oxidoreductase (EC 1.-.-.-), similar to Q9EWQ8 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt: 89, E(): 4.5e-09, (24.6% identity in 358 aa overlap). TBparse score is 0.929.; oxidoreductase	complement(1265472..1266488)	Mycobacterium tuberculosis H37Rv	885119
NP_215655.1	CDS	Rv1139c	NC_000962.2	1266485	1266985	R	Rv1139c, (MTCI65.06c), len: 166 aa. Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein, YBPQ (168 aa), FASTA scores: opt: 446, E(): 2.2e-26, (38.4% identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins, Rv0740, Rv0750. TBparse score is 0.911.; hypothetical protein	complement(1266485..1266985)	Mycobacterium tuberculosis H37Rv	885110
NP_215656.1	CDS	Rv1140	NC_000962.2	1267347	1268195	D	Rv1140, (MTCI65.07), len: 282 aa. Probable integral membrane protein. Weak similarity in C-terminus to hypothetical Escherichia coli proteins YPRA and YPRB, possibly membrane-bound e.g. YPRA_ECOLI HYPOTHETICAL 24.3 kDa PROTEIN (URF 1) (217 aa), FASTA scores: opt: 166, E(): 0.00062, (31.0% identity in 158 aa overlap). TBparse score is 0.927.; integral membrane protein	1267347..1268195	Mycobacterium tuberculosis H37Rv	885117
NP_215657.1	CDS	echA11	NC_000962.2	1268203	1269009	R	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	complement(1268203..1269009)	Mycobacterium tuberculosis H37Rv	886024
NP_215658.1	CDS	echA10	NC_000962.2	1269152	1269958	R	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	complement(1269152..1269958)	Mycobacterium tuberculosis H37Rv	885458
NP_215659.1	CDS	mcr	NC_000962.2	1270062	1271144	D	Rv1143, (MTCI65.10), len: 360 aa. Probable mcr, alpha-methylacyl-CoA racemase (EC 5.1.99.4). Strong similarity to other alpha-methylacyl-CoA racemases and also some similarity to L-carnitine dehydratase (EC 4.2.1.89) e.g. U89905|g1552373 methylacyl-CoA racemase alpha from Norway rat (361 aa), FASTA scores: opt: 1035, E():0, (47.2% identity in 339 aa overlap). Equivalent to (but longer than) Z94723|MLCB33_13 Mycobacterium leprae (253 aa) (85.3% identity in 245 aa overlap). Also similar to Mycobacterium tuberculosis putative racemases Rv0855, Rv1866, Rv3272. TBparse score is 0.906.; alpha-methylacyl-CoA racemase	1270062..1271144	Mycobacterium tuberculosis H37Rv	885067
NP_215660.1	CDS	Rv1144	NC_000962.2	1271156	1271908	D	Rv1144, (MTCI65.11), len: 250 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases e.g. NP_104056.1|NC_002678 3-hydroxyacyl-CoA dehydrogenase type II from Mesorhizobium loti (253 aa); NP_251244.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (255 aa); AAK15008.1|AF233685_1|AF233685 short chain L-3-hydroxyacyl-CoA dehydrogenase from Mus musculus (261 aa); HSU73514|g1778354|XH98G2 human short-chain alcohol dehydrogenase from Homo sapiens (261 aa), FASTA scores: opt: 875, E(): 0, (60.1% identity in 253 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is 0.864.; short-chain type dehydrogenase/reductase	1271156..1271908	Mycobacterium tuberculosis H37Rv	885932
NP_215661.1	CDS	mmpL13a	NC_000962.2	1272423	1273334	D	Rv1145, (MTCI65.12), len: 303 aa. Probable mmpL13a, conserved transmembrane transport protein (see citation below), member of RND superfamily, showing some similarity to putative Mycobacterial and Streptomyces membrane proteins e.g. MTCY987|g1781238 from Mycobacterium tuberculosis (962 aa), FASTA scores: opt: 213, E(): 1.9e-06, (28.0% identity in 296 aa overlap); etc. Strong similarity to U92075|MMU92075_5 hypothetical protein from Mycobacterium marinum (256 aa), FASTA scores: opt: 957, E(): 0, (57.6% identity in 257 aa overlap). Should continue as mmpL13B|Rv1146, but frameshift required. Sequence has been checked and is identical in M. tuberculosis strain CDC1551, and Mycobacterium bovis strain AF2122/97. BELONGS TO THE MMPL FAMILY. TBparse score is 0.919.; transmembrane transport protein MmpL13A	1272423..1273334	Mycobacterium tuberculosis H37Rv	885798
NP_215662.1	CDS	mmpL13b	NC_000962.2	1273355	1274767	D	Rv1146, (MTCI65.13), len: 470 aa. Probable mmpL13b, conserved transmembrane transport protein (see citation below), member of RND superfamily, showing some similarity to putative Mycobacterial and Streptomyces membrane proteins e.g. Q53902|C40046 antibiotic transport-associated protein from Streptomyces coelicolor (711 aa), FASTA scores: opt: 193, E(): 2.1e-05, (28.9% identity in 394 aa overlap); etc. Could be in frame with previous ORF mmpL13A|Rv1145, but no sequence error apparent to account for this; sequence is identical in M. tuberculosis strain CDC1551, and Mycobacterium bovis strain AF2122/97. BELONGS TO THE MMPL FAMILY. TBparse score is 0.929.; transmembrane transport protein MmpL13B	1273355..1274767	Mycobacterium tuberculosis H37Rv	885575
NP_215663.1	CDS	Rv1147	NC_000962.2	1274900	1275550	D	Rv1147, (MTCI65.14), len: 216 aa. Conserved hypothetical protein, similar to many conserved hypothetical proteins, and some similarity to several methyltransferases e.g. Q05197|PMTA_RHOSH phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) from R. sphaeroides (203 aa), FASTA scores: opt: 156, E( ): 0.00073, (27.6% identity in 156 aa overlap). TBparse score is 0.913.; hypothetical protein	1274900..1275550	Mycobacterium tuberculosis H37Rv	885471
NP_215664.1	CDS	Rv1148c	NC_000962.2	1276300	1277748	R	Rv1148c, (MTCI65.15c), len: 482 aa. Conserved hypothetical ORF in REP13E12 degenerate repeat, nearly identical to other hypothetical Mycobacterium tuberculosis proteins in REP13E12 repeats, although similarity extends upstream past proposed f-Met start. Very similar to other REP13E12 proteins e.g. Rv1945, Rv3467, Rv0094c, Rv1128c etc. TBparse score is 0.917.; hypothetical protein	complement(1276300..1277748)	Mycobacterium tuberculosis H37Rv	885451
NP_215665.1	CDS	Rv1149	NC_000962.2	1277893	1278300	D	Rv1149, (MTCI65.16), len: 135 aa. Possible transposase. Identical to 117 aa N-terminal region of S21394|X65618 transposase of Mycobacterium tuberculosis (308 aa), FASTA scores: opt: 823, E(): 0, (99.1% identity in 117 aa overlap). Second copy is Rv1042c|MTCY10G2.07. TBparse score is 0.926.; transposase	1277893..1278300	Mycobacterium tuberculosis H37Rv	885164
NP_215667.1	CDS	Rv1151c	NC_000962.2	1278904	1279617	R	Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase	complement(1278904..1279617)	Mycobacterium tuberculosis H37Rv	886026
NP_215668.1	CDS	Rv1152	NC_000962.2	1279655	1280020	D	Rv1152, (MTCI65.19), len: 121 aa (Start uncertain). Probable transcriptional regulatory protein, some similarity to others e.g. YHCF_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR (121 aa), FASTA scores: opt: 187, E(): 1.9e-06, (34.9% identity in 106 aa overlap). TBparse score is 0.876. Helix turn helix motif from aa 42-63 (+3.10 SD).; transcriptional regulatory protein	1279655..1280020	Mycobacterium tuberculosis H37Rv	885985
NP_215669.1	CDS	omt	NC_000962.2	1279998	1280846	R	Rv1153c, (MTCI65.20c), len: 282 aa. Probable omt, O-methyltransferase (EC 2.1.1-), similar to TCMP_STRGA|P39887 Tetracenomycin polyketide synthesis O-methyltransferase tcmP (EC 2.1.1.-) from Streptomyces glaucescens (270 aa), FASTA scores: opt: 368, E(): 1.7e-17, (31.3% identity in 233 aa overlap). TBparse score is 0.926.; O-methyltransferase	complement(1279998..1280846)	Mycobacterium tuberculosis H37Rv	885994
NP_215670.1	CDS	Rv1154c	NC_000962.2	1280843	1281484	R	Rv1154c, (MTCI65.21c), len: 213 aa. Hypothetical unknown protein, start uncertain. TBparse score is 0.911; hypothetical protein	complement(1280843..1281484)	Mycobacterium tuberculosis H37Rv	885991
NP_215671.1	CDS	Rv1155	NC_000962.2	1281429	1281872	D	Rv1155, (MTCI65.22), len: 147 aa. Conserved hypothetical protein. Similar to other hypothetical proteins e.g. AL079356|SC6G9.20 Streptomyces coelicolor (144 aa), FASTA scores: opt: 478, E(): 2.8e-26, (55.7% identity in 140 aa overlap); and Mycobacterium tuberculosis proteins Rv1875, Rv0121c, Rv2074. TBparse score is 0.912.; hypothetical protein	1281429..1281872	Mycobacterium tuberculosis H37Rv	885604
NP_215672.1	CDS	Rv1156	NC_000962.2	1282306	1282893	D	Rv1156, (MTCI65.23), len: 195 aa. Conserved hypothetical protein, highly similar to CAC32318.1|AL583944 conserved hypothetical protein from Streptomyces coelicolor (197 aa). TBparse score is 0.915.; hypothetical protein	1282306..1282893	Mycobacterium tuberculosis H37Rv	885593
NP_215673.1	CDS	Rv1157c	NC_000962.2	1283056	1284171	R	Rv1157c, (MTCI65.24c), len: 371 aa. Conserved hypothetical Ala-, Pro-rich protein, similar to other proline rich proteins and extensins e.g. GBU04267|g451543 sea-island cotton proline-rich protein of cotton fiber (214 aa), FASTA scores: opt: 305, E(): 3.9e-05, (35.7% identity in 182 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. First start taken. TBparse score is 0.918.; hypothetical protein	complement(1283056..1284171)	Mycobacterium tuberculosis H37Rv	885878
NP_215674.1	CDS	Rv1158c	NC_000962.2	1284179	1284862	R	Rv1158c, (MTCI65.25c), len: 227 aa. Conserved hypothetical Ala-, Pro-rich protein, similar to other proline rich proteins and extensins e.g. MMSAP62|g633250 house mouse (485 aa), FASTA scores: opt: 367, E(): 1.2e-08, (36.3% identity in 212 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. TBparse score is 0.915.; hypothetical protein	complement(1284179..1284862)	Mycobacterium tuberculosis H37Rv	888930
NP_215675.1	CDS	pimE	NC_000962.2	1284992	1286287	D	involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase	1284992..1286287	Mycobacterium tuberculosis H37Rv	885899
YP_177641.1	CDS	phhB	NC_000962.2	1286284	1286568	R	4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase	complement(1286284..1286568)	Mycobacterium tuberculosis H37Rv	3205109
NP_215676.1	CDS	mutT2	NC_000962.2	1286595	1287020	D	Rv1160, (MTCI65.27), len: 141 aa. Probable mutT2, mutator protein or homolog (EC 3.6.1.-) (see citation below). More similar to D908197|g1742860 MutT homolog from Escherichia coli (135 aa), FASTA scores: opt: 226, E():1.1e-08, (39.7% identity in 116 aa overlap); than to MUTT_ECOLI|P08337 MUTATOR MUTT PROTEIN from Escherichia coli (129 aa), FASTA scores: opt: 180, E(): 1.2e-05, (27.1% identity in 129 aa overlap). Contains PS00893 mutT domain signature. TBparse score is 0.899.; 7,8-dihydro-8-oxoguanine-triphosphatase	1286595..1287020	Mycobacterium tuberculosis H37Rv	888485
NP_215677.1	CDS	narG	NC_000962.2	1287328	1291026	D	Rv1161, (MTCI65.28), len: 1232 aa. Probable narG, respiratory nitrate reductase alpha chain (EC 1.7.99.4). Similar to others e.g. NARG_BACSU NITRATEREDUCTASE ALPHA CHAIN from Bacillus subtilis (1228 aa), FASTA scores: opt: 4218, E(): 0, (50.3% identity in 1229 aa overlap); etc. Also highly similar to N-terminal part of Rv1736c|MTCY04C12.21c|NARX PROBABLE NITRATE REDUCTASE from Mycobacterium tuberculosis (85.1% identity in 281 aa overlap). Contains prokaryotic molybdopterin oxidoreductase signatures 1 and 2 (PS00551, PS00490). TBparse score is 0.908. BELONGS TO THE PROKARYOTIC MOLYBDOPTERIN-CONTAINING OXIDOREDUCTASE FAMILY.; respiratory nitrate reductase subunit alpha NarG	1287328..1291026	Mycobacterium tuberculosis H37Rv	885573
NP_215678.1	CDS	narH	NC_000962.2	1291065	1292741	D	Rv1162, (MTCI65.29), len: 558 aa. Probable narH, respiratory nitrate reductase beta chain (EC 1.7.99.4). Similar to others e.g. NARH_BACSU|P42176 NITRATE REDUCTASE BETA CHAIN from Bacillus subtilis (487 aa), FASTA scores: opt: 2049, E(): 0, (56.8% identity in 488 aa overlap); etc. Contains PS00190 cytochrome c family heme-binding site signature. TBparse score is 0.899.; respiratory nitrate reductase subunit beta NarH	1291065..1292741	Mycobacterium tuberculosis H37Rv	888265
NP_215679.1	CDS	narJ	NC_000962.2	1292798	1293403	D	Rv1163, (MTCI65.30), len: 201 aa. Probable narJ, respiratory nitrate reductase delta chain (EC 1.7.99.4). Similar to others e.g. P42178|NARJ_BACSU NITRATE REDUCTASE DELTA CHAIN from Bacillus subtilis (184 aa), FASTA scores: opt: 254, E(): 1.9e-10, (31.8% identity in 179 aa overlap); etc. Strong similarity to region from aa 260 - 410 of Rv1736c|MTCY04C12.21c|NARX PROBABLE NITRATE REDUCTASE from Mycobacterium tuberculosis (64.8% identity in 159 aa overlap). TBparse score is 0.892.; respiratory nitrate reductase subunit delta NarJ	1292798..1293403	Mycobacterium tuberculosis H37Rv	885890
NP_215680.1	CDS	narI	NC_000962.2	1293406	1294146	D	Rv1164, (MTCI65.31), len: 246 aa. Probable narI, respiratory nitrate reductase gamma chain (EC 1.7.99.4). Similar to others e.g. NARI_BACSU|P42177 NITRATE REDUCTASE GAMMA CHAIN from Bacillus subtilis (223 aa), FASTA scores: opt: 652, E(): 0; (41.6% identity in 221 aa overlap); etc. Highly similar to C-terminal part of Rv1736c|MTCY04C12.21c|NARX PROBABLE NITRATE REDUCTASE (GAMMA CHAIN) from Mycobacterium tuberculosis (68.6% identity in 239 aa overlap). TBparse score is 0.904.; respiratory nitrate reductase subunit gamma NarI	1293406..1294146	Mycobacterium tuberculosis H37Rv	888935
NP_215681.1	CDS	typA	NC_000962.2	1294168	1296054	D	Rv1165, (MTV005.01-MTCI65.32), len: 628 aa. Possible typA (alternate gene name: bipA), GTP-binding translation elongation factor, similar to several e.g. P32132|TYPA_ECOLI|BIPA|B387 Escherichia coli (591 aa); YIHK_SYNY3|P72749 gtp-binding protein TYPA/BIPA homolog from synechocystis sp. (597 aa), FASTA scores: E(): 0, (46.9% identity in 610 aa overlap); and to elongation factor EF-G from many organims e.g. EFG_MICLU|P09952 micrococcus luteus (701 aa), FASTA scores: E(): 3e-24, (29.8% identity in 500 aa overlap). BELONGS TO THE GTP-BINDING ELONGATION FACTOR FAMILY, TYPA SUBFAMILY.; bipA; GTP-binding translation elongation factor TypA	1294168..1296054	Mycobacterium tuberculosis H37Rv	886038
NP_215682.1	CDS	lpqW	NC_000962.2	1296152	1298059	D	Rv1166, (MTV005.02), len: 635 aa. Probable lpqW, conserved lipoprotein, almost identical in part to G2384665|AF009358 Mycobacterium tuberculosis gene fragment ORFA2-898 (FRAGMENT) (59 aa) (93.9% identity in 49 aa overlap) (see * below). Also similar to Rv1280c and Rv2585c. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. [* Note: Unpublished. Identification of Mycobacterium tuberculosis peptides that stimulate immune human peripheral blood monocytes. Nano F.E., Doran J.L., Treit J.D., Moran A.J.]; lipoprotein LpqW	1296152..1298059	Mycobacterium tuberculosis H37Rv	886036
NP_215683.1	CDS	Rv1167c	NC_000962.2	1298087	1298692	R	Rv1167c, (MTV005.03c), len: 201 aa. Probable transcriptional regulator, similar to several e.g. D1022772|D85417 hemR from Propionibacterium freudenreichii (243 aa), FASTA scores: opt: 268, E(): 5.4e-16, (35.9% identity in 198 aa overlap) and AL022268|SC4H2.32 Streptomyces coelicolor (111 aa), FASTA scores: opt: 274, E(): 5e-11, (55.1% identity in 89 aa overlap).; transcriptional regulatory protein	complement(1298087..1298692)	Mycobacterium tuberculosis H37Rv	888758
YP_177791.1	CDS	PPE17	NC_000962.2	1298764	1299804	R	Rv1168c, (MTV005.04c), len: 346 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: opt: 504, E(): 0, (36.6% identity in 388 aa overlap).; PPE family protein	complement(1298764..1299804)	Mycobacterium tuberculosis H37Rv	885990
YP_177792.1	CDS	PE11	NC_000962.2	1299822	1300124	R	Rv1169c, (MTV005.05c), len: 100 aa. Member of the Mycobacterium tuberculosis PE family of proteins (see Brennan & Delogu 2002), e.g. O05297|Z93777|MTCI364.07 (99 aa), FASTA scores: opt: 209, E(): 1.6e-15, (37.4% identity in 99 aa overlap). Also simlar to the N-terminus of P77909|U76006 ESTERASE/LIPASE (EC 3.1.1.3) from Mycobacterium tuberculosis (437 aa), FASTA scores: opt: 193, E(): 4.4e-14, (37.2% identity in 94 aa overlap). Contains a helix-turn-helix motif from aa 88-109 (+2.76 SD).; PE family protein	complement(1299822..1300124)	Mycobacterium tuberculosis H37Rv	885930
NP_215686.1	CDS	mshB	NC_000962.2	1300304	1301215	D	Rv1170, (MTV005.06), len: 303 aa. mshB, N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopy ra noside Deacetylase (GlcNAc-Ins deacetylase) (see citation below), similar to Q54358|X79146 lmbE gene from Streptomyces lincolnensis (270 aa), FASTA scores: opt: 308, E(): 1.2e-15, (32.0% identity in 278 aa overlap). Also similar to Rv1082|MCA Mycothiol conjugate amidase from Mycobacterium tuberculosis (288 aa).; N-Acetyl-1-D-myo-Inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase mshB (GlcNAc-Ins deacetylase)	1300304..1301215	Mycobacterium tuberculosis H37Rv	885997
NP_215687.2	CDS	Rv1171	NC_000962.2	1301307	1301747	D	Rv1171, (MTV005.07), len: 146 aa. Conserved hypothetical protein, possibly transmembrane protein. Start has been changed since first submission.; hypothetical protein	1301307..1301747	Mycobacterium tuberculosis H37Rv	885986
YP_177793.1	CDS	PE12	NC_000962.2	1301755	1302681	R	Rv1172c, (MTV005.08c), len: 308 aa. Member of the Mycobacterium tuberculosis PE family of proteins (see Brennan & Delogu 2002), e.g. P71748|Z81368|MTCY253.25C (361 aa), FASTA scores: opt: 483, E(): 7.8e-22, (46.4% identity in 192 aa overlap).; PE family protein	complement(1301755..1302681)	Mycobacterium tuberculosis H37Rv	885988
NP_215689.1	CDS	fbiC	NC_000962.2	1302931	1305501	D	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase	1302931..1305501	Mycobacterium tuberculosis H37Rv	886061
NP_215690.1	CDS	TB8.4	NC_000962.2	1305669	1306001	R	Rv1174c, (MTV005.10c), len: 110 aa. TB8.4, low molecular weight T-cell antigen (see citations below), hypothetical unknown secreted protein.; low molecular weight T-cell antigen TB8.4	complement(1305669..1306001)	Mycobacterium tuberculosis H37Rv	886082
NP_215691.1	CDS	fadH	NC_000962.2	1306202	1308226	R	Rv1175c, (MTV005.11c), len: 674 aa. Probable fadH, NADPH-dependent 2,4-dienoyl-CoA reductase (EC 1.3.1.34), highly similar to others e.g. NP_251782.1|NC_002516 2,4-dienoyl-CoA reductase FadH1 from Pseudomonas aeruginosa (679 aa); CAC01564.1|AL391039 2,4-dienoyl-CoA reductase [NADPH] from Streptomyces coelicolor (671 aa); P42593|FADH_ECOLI 2,4-dienoyl-CoA reductase from Escherichia coli (671 aa), FASTA scores: opt: 2344, E(): 0, (53.1% identity in 671 aa overlap); etc. Also similar to Rv3359|MTV004.16 PUTATIVE OXIDOREDUCTASE from Mycobacterium tuberculosis (396 aa).; NADPH dependent 2,4-dienoyl-CoA reductase	complement(1306202..1308226)	Mycobacterium tuberculosis H37Rv	886053
NP_215692.1	CDS	Rv1176c	NC_000962.2	1308223	1308792	R	Rv1176c, (MTV005.12c), len: 189 aa. Conserved hypothetical protein, some similarity to P94443|D78508 hypothetical protein from Bacillus subtilis (182 aa), FASTA scores: opt: 219, E(): 1.7e-15, (25.1% identity in 183 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein Rv0047c.; hypothetical protein	complement(1308223..1308792)	Mycobacterium tuberculosis H37Rv	886080
NP_215693.1	CDS	fdxC	NC_000962.2	1309005	1309331	D	Rv1177, (MTV005.13), len: 108 aa. Probable fdxC, ferredoxin (EC 1.-.-.-), equivalent to NP_302047.1|NC_002677 ferredoxin from Mycobacterium leprae (108 aa); P00215|FER_MYCSM FERREDOXIN from Mycobacterium smegmatis (106 aa), FASTA scores: opt: 705, E(): 0, (87.7% identity in 106 aa overlap). Also highly similar to many e.g. JH0239 ferredoxin precursor from Saccharopolyspora erythraea (105 aa); P24496|FER_SACER FERREDOXIN from Saccharopolyspora erythraea (106 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. BELONGS TO THE BACTERIAL TYPE FERREDOXIN FAMILY. COFACTOR: BINDS 1 4FE-4S CLUSTER AND A 3FE-4S CLUSTER (BY SIMILARITY).; ferredoxin FdxC	1309005..1309331	Mycobacterium tuberculosis H37Rv	885869
NP_215694.1	CDS	Rv1178	NC_000962.2	1309364	1310452	D	catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase	1309364..1310452	Mycobacterium tuberculosis H37Rv	886031
NP_215695.1	CDS	Rv1179c	NC_000962.2	1310480	1313299	R	Rv1179c, MTV005.15c, len: 939 aa. Hypothetical unknown protein.; hypothetical protein	complement(1310480..1313299)	Mycobacterium tuberculosis H37Rv	886083
NP_215696.1	CDS	pks3	NC_000962.2	1313725	1315191	D	Rv1180, (MTV005.16), len: 488 aa. Probable polyketide beta-ketoacyl synthase (EC 2.3.1.-), equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below), and similar to the N-terminus of many polyketide synthases e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from mycobacterium bovis (2110 aa), FASTA scores: opt: 2115, E(): 0, (66.5% identity in 472 aa overlap). Also similar to, and same length as P96284|Z83858|MTCY24G1.02 M. tuberculosis (496 aa), FASTA scores: opt: 1424, E(): 0, (50.9% identity in 444 aa overlap). Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site, also PS00606 Beta-ketoacyl synthases active site. BELONGS TO THE BETA-KETOACYL-ACP SYNTHASES FAMILY.; polyketide beta-ketoacyl synthase PKS3	1313725..1315191	Mycobacterium tuberculosis H37Rv	886055
NP_215697.1	CDS	pks4	NC_000962.2	1315234	1319982	D	Rv1181, (MTV005.17), len: 1582 aa. Probable polyketide synthase, similar to many e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from mycobacterium bovis (2110 aa), FASTA scores: opt: 3518, E(): 0, (59.7% identity in 1614 aa overlap). Note that this similarity extends upstream of the first initiation codon into the upstream MTV005.16; however the stop codon at the end of MTV005.16 is present in at least 4 independent clones (BAC, cosmid and pUC) from the genome. The two CDS's may represent separate modules of the polyketide synthase.; polyketide beta-ketoacyl synthase PKS4	1315234..1319982	Mycobacterium tuberculosis H37Rv	886081
NP_215698.1	CDS	papA3	NC_000962.2	1320035	1321453	D	Rv1182, (MTV005.18), len: 472 aa. Probable papA3, conserved polyketide synthase (PKS) associated protein, similar to other Mycobacterial hypothetical proteins e.g. Q49618|U00010 B1170_C1_180 from Mycobacterium leprae (471 aa), FASTA scores: opt: 2526, E(): 0, (75.6% identity in 471 aa overlap). Similar to other Mycobacterium tuberculosis hypothetical papA proteins; Rv3824c, Rv3820c, Rv1528c.; polyketide synthase associated protein PapA3	1320035..1321453	Mycobacterium tuberculosis H37Rv	886072
NP_215699.1	CDS	mmpL10	NC_000962.2	1321520	1324528	D	Rv1183, (MTV005.19), len: 1002 aa. Probable mmpL10, conserved transmembrane transport protein (see Tekaia et al., 1999), member of RND superfamily, similar to many Mycobacterial hypothetical membrane proteins e.g. Q49619|U00010 from Mycobacterium leprae (1008 aa), FASTA scores: opt: 4545, E(): 0, (70.6% identity in 978 aa overlap); etc. BELONGS TO THE MMPL FAMILY.; transmembrane transport protein MmpL10	1321520..1324528	Mycobacterium tuberculosis H37Rv	886068
NP_215700.1	CDS	Rv1184c	NC_000962.2	1324532	1325611	R	Rv1184c, (MTV005.20c), len: 359 aa. Possible exported protein with potential N-terminal signal sequence. Similar to several Mycobacterial hypothetical proteins e.g. Q49633|U00010) Protein B1170_F3_112 from M. leprae (391 aa), FASTA scores: opt: 1422, E(): 0, (62.7% identity in 338 aa overlap). Also similar to Rv3822, Rv3539, Rv1430, Rv0151c, etc.; hypothetical protein	complement(1324532..1325611)	Mycobacterium tuberculosis H37Rv	886063
NP_215701.1	CDS	fadD21	NC_000962.2	1325776	1327512	R	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	complement(1325776..1327512)	Mycobacterium tuberculosis H37Rv	886065
NP_215702.1	CDS	Rv1186c	NC_000962.2	1327689	1329305	R	Rv1186c, (MTV005.22c), len: 538 aa. Conserved hypothetical protein, similar to AL117385|SC5G9.24 hypothetical protein from Streptomyces coelicolor (555 aa), FASTA scores: opt: 485, E(): 2.3e-23, (32.6% identity in 568 aa overlap). Contains helix turn helix motif from aa 488-509 (+2.81 SD).; hypothetical protein	complement(1327689..1329305)	Mycobacterium tuberculosis H37Rv	886057
NP_215703.1	CDS	rocA	NC_000962.2	1329390	1331021	D	Rv1187, (MTV005.23), len: 543 aa. Probable rocA, pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12), similar to many e.g. PUT2_HUMAN|P30038 human delta-1-pyrroline-5-carboxylate dehydrogenase (563 aa), FASTA scores: opt: 1596, E():0, (46.0% identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis hypothetical dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site.; pyrroline-5-carboxylate dehydrogenase ROCA	1329390..1331021	Mycobacterium tuberculosis H37Rv	886058
NP_215704.1	CDS	Rv1188	NC_000962.2	1331021	1332010	D	Rv1188, (MTV005.24), len: 329 aa. Possible putA, proline dehydrogenase (EC 1.5.99.8), similar to part of Q52711|X78346 proline dehydrogenase from Rhodobacter capsulatus (1127 aa), FASTA scores: opt: 194, E(): 1.5e-07, (31.2% identity in 349 aa overlap). Also similar to two Bacillus subtilis proline dehydrohenases E1184363|Z99120 (302 aa), FASTA scores: opt: 509, E(): 0, (37.1% identity in 313 aa overlap); and E1182272|Z99105 (303 aa), FASTA scores: opt: 513, E(): 0, (32.5% identity in 311 aa overlap). Highly similar to AL035569|SC8D9.31 Streptomyces coelicolor (308 aa), FASTA scores: opt: 984, E(): 0, (50.0% identity in 312 aa overlap).; proline dehydrogenase	1331021..1332010	Mycobacterium tuberculosis H37Rv	886054
NP_215705.1	CDS	sigI	NC_000962.2	1332092	1332964	D	member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigI	1332092..1332964	Mycobacterium tuberculosis H37Rv	886079
NP_215706.1	CDS	Rv1190	NC_000962.2	1332980	1333858	D	Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap).; hypothetical protein	1332980..1333858	Mycobacterium tuberculosis H37Rv	886049
NP_215707.1	CDS	Rv1191	NC_000962.2	1333931	1334845	D	Rv1191, (MTCI364.03), len: 304 aa. Conserved hypothetical protein, similar to Q54528 RDMC from Streptomyces purpurascens (298 aa), FASTA scores: opt: 196, E(): 1.5e-05, (27.5% identity in 269 aa overlap); Rv0134|MTCI5.08 (300 aa), FASTA scores: opt: 197, E(): 6.6e-06, (26.4% identity in 299 aa overlap), some similarity to PIP_NEIGO|P42786 proline iminopeptidase (EC 3.4. 11.5) (310 aa), FASTA scores: opt: 196, E(): 1.3e-05, (32.2% identity in 152 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature.; hypothetical protein	1333931..1334845	Mycobacterium tuberculosis H37Rv	886041
NP_215708.1	CDS	Rv1192	NC_000962.2	1334927	1335754	D	Rv1192, (MTCI364.04), len: 275 aa. Hypothetical unknown protein, contains PS00120 lipases, serine active site.; hypothetical protein	1334927..1335754	Mycobacterium tuberculosis H37Rv	886007
NP_215709.1	CDS	fadD36	NC_000962.2	1335794	1337215	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	1335794..1337215	Mycobacterium tuberculosis H37Rv	886074
NP_215710.1	CDS	Rv1194c	NC_000962.2	1337248	1338513	R	Rv1194c, (MTCI364.06c), len: 421 aa. Conserved hypothetical protein, highly similar to Q50018 possible transcriptional activator from Mycobacterium leprae (517 aa), FASTA scores: opt: 1960, E(): 0, (69.8% identity in 421 aa overlap). Also similar to Mycobacterium tuberculosis Rv2370c|MTCY27.10, (62.0% identity in 421 aa overlap) and Rv1453|MTCY493.01c.; hypothetical protein	complement(1337248..1338513)	Mycobacterium tuberculosis H37Rv	886040
YP_177794.1	CDS	PE13	NC_000962.2	1339003	1339302	D	Rv1195, (MTCI364.07), len: 99 aa. Member of Mycobacterium tuberculosis PE family (see Brennan & Delogu 2002), e.g. Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kd protein (498 aa), FASTA scores: opt: 307, E(): 1.4e-12, (56.3% identity in 96 aa overlap), similar to MTCY21C12.10c (99 aa), FASTA scores: opt:295, E(): 1.9e-11, (51.5% identity in 97 aa overlap).; PE family protein	1339003..1339302	Mycobacterium tuberculosis H37Rv	886044
YP_177795.1	CDS	PPE18	NC_000962.2	1339349	1340524	D	Rv1196, (MTCI364.08), len: 391 aa. PPE18 (alternate gene name: mtb39a). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to others e.g. Y07P_MYCTU|Q11031 hypothetical 40.0 kDa protein cy02b10.25c (396 aa), FASTA scores: opt: 2124, E(): 0, (85.1% identity in 397 aa overlap). Note that expression of Rv1196 was demonstrated in lysates by immunodetection (see Dillon et al., 1999).; mtb39a; PPE family protein	1339349..1340524	Mycobacterium tuberculosis H37Rv	886073
NP_215713.1	CDS	esxK	NC_000962.2	1340659	1340955	D	Rv1197, (MT1235, MTCI364.09), len: 98 aa. esxK, ESAT-6 like protein (see citation below). Member of M. tuberculosis hypothetical QILSS protein family with Rv1038c, etc. Almost identical to MTCY98.023c (98 aa) (99.0% identity in 98 aa overlap) and MTCY10G2.11 (98 aa), FASTA scores: opt: 643, E(): 0, (99.0% identity in 98 aa overlap); highly similar to Q49945|U1756C from Mycobacterium leprae (100 aa), FASTA scores: opt: 377, E(): 8e-21, (58.3% identity in 96 aa overlap). BELONGS TO THE ESAT6 FAMILY.; ES6_3, TB11.0, QILSS; Esat-6 like protein esxK (Esat-6 like protein 3)	1340659..1340955	Mycobacterium tuberculosis H37Rv	886051
NP_215714.1	CDS	esxL	NC_000962.2	1341006	1341290	D	Rv1198, (MT1236, MTCI364.10), len: 94 aa. esxL, ESAT-6 like protein (see citation below). Member of the ESAT-6 family with Rv3619c, Rv1037c, etc. Almost identical to MTCY10G2.12 (94 aa) (97.9% identity in 94 aa overlap) and MTCY98.022c (94 aa) (94.7% identity in 94 aa overlap). Highly similar to Q49946|U1756D Mycobacterium leprae (95 aa), FASTA scores: opt: 403, E(): 1.1e-22, (64.1% identity in 92 aa overlap). SEEMS TO BELONG TO THE ESAT6 FAMILY.; ES6_4, Mtb9.9C; putative ESAT-6 like protein ESXL (ESAT-6 like protein 4)	1341006..1341290	Mycobacterium tuberculosis H37Rv	886090
NP_215715.1	CDS	Rv1199c	NC_000962.2	1341358	1342605	R	Rv1199c, (MTCI364.11c), len: 415 aa. Possible transposase for IS1081, identical to TRA1_MYCBO|P35882 transposase for insertion sequence element (415 aa); region identical to MTCY441.35 (100.0% identity in 261 aa overlap); and almost identical to MTCY10G2.02c (415 aa) (99.8% identity in 415 aa overlap). Contains PS01007 Transposases, Mutator family, signature, PS00435 Peroxidases proximal heme-ligand signature.; transposase	complement(1341358..1342605)	Mycobacterium tuberculosis H37Rv	886092
NP_215716.1	CDS	Rv1200	NC_000962.2	1342942	1344219	D	Rv1200, (MTCI364.12), len: 425 aa. Probable conserved integral membrane transport protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. YHJE_ECOLI|P37643 hypothetical metabolite transport protein from Escherichia coli (440 aa), FASTA scores: opt: 1047, E(): 0, (39.1% identity in 427 aa overlap); etc. Contains PS00217 Sugar transport proteins signature 2. The transcription of this CDS seems to be activated in macrophages (see citation below).; integral membrane transport protein	1342942..1344219	Mycobacterium tuberculosis H37Rv	886087
NP_215717.1	CDS	Rv1201c	NC_000962.2	1344216	1345169	R	Rv1201c, (MTCI364.13c), len: 317 aa. Probable transferase (EC 2.-.-.-). Highly similar to Q49948|U1756F Mycobacterium leprae (317 aa), FASTA scores: opt: 1776, E(): 0, (84.9% identity in 317 aa overlap), also Q46064 ORF3 protein from CORYNEBACTERIUM GLUTAMICUM (316 aa), FASTA scores: opt: 864, E(): 0, (44.1% identity in 311 aa overlap).; transferase	complement(1344216..1345169)	Mycobacterium tuberculosis H37Rv	886088
YP_177796.1	CDS	dapE	NC_000962.2	1345260	1346324	D	catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase	1345260..1346324	Mycobacterium tuberculosis H37Rv	887386
NP_215719.1	CDS	Rv1203c	NC_000962.2	1346321	1346905	R	Rv1203c, (MTCI364.15c), len: 194 aa. Hypothetical unknown protein.; hypothetical protein	complement(1346321..1346905)	Mycobacterium tuberculosis H37Rv	886086
NP_215720.1	CDS	Rv1204c	NC_000962.2	1346936	1348624	R	Rv1204c, (MTCI364.16c), len: 562 aa. Conserved hypothetical protein, some similarity to Q55103 CHO-ORF2 from STREPTOMYCES SP. (642 aa), FASTA scores: opt: 215, E(): 3.6e-06, (26.4% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.; hypothetical protein	complement(1346936..1348624)	Mycobacterium tuberculosis H37Rv	887552
NP_215721.1	CDS	Rv1205	NC_000962.2	1348719	1349282	D	Rv1205, (MTCI364.17), len: 187 aa. Conserved hypothetical protein, similar to Q49952 cosmid B1756 from Mycobacterium leprae (187 aa), FASTA scores: opt: 865, E(): 0, (72.4% identity in 174 aa overlap), also similar to FAS6_RHOFA|P46378 hypothetical 21.1 kDa protein in fasciation locus (ORF6) (198 aa), FASTA scores: opt: 368, E(): 1.3e-17, (37.4% identity in 174 aa overlap). Some similarity to YJL055W Hypothetical protein in BTN1-PEP8 intergenic region from Saccharomyces cerevisiae and P48636 HYPOTHETICAL protein in AZU 5'REGION from Pseudomonas aeruginosa. The transcription of this CDS seems to be activated specifically in host granulomas (see citation below).; hypothetical protein	1348719..1349282	Mycobacterium tuberculosis H37Rv	886075
NP_215722.1	CDS	fadD6	NC_000962.2	1349332	1351125	D	activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization; long-chain-acyl-CoA synthetase	1349332..1351125	Mycobacterium tuberculosis H37Rv	887549
NP_215723.1	CDS	folP2	NC_000962.2	1351191	1352147	D	Rv1207, (MTCI364.19), len: 318 aa. Probable folP2, Dihydropteroate synthase 2 (EC 2.5.1.15), similar to many e.g. DHPS_ECOLI|P26282 Escherichia coli (282 aa), FASTA scores: opt: 480, E(): 1.9e-22, (34.4% identity in 270 aa overlap). Contains PS00792 dihydropteroate synthase signature 1, PS00793 dihydropteroate synthase signature 2.; dihydropteroate synthase 2 FolP2	1351191..1352147	Mycobacterium tuberculosis H37Rv	887447
NP_215724.1	CDS	Rv1208	NC_000962.2	1352144	1353118	D	Rv1208, (MTCI364.20), len: 324 aa. Conserved hypothetical protein, similar to Q49955|U1756L Mycobacterium leprae (318 aa), FASTA scores, opt: 1621, E(): 0, (80.5% identity in 318 aa overlap).; putative glucosyl-3-phosphoglycerate synthase	1352144..1353118	Mycobacterium tuberculosis H37Rv	886085
NP_215725.1	CDS	Rv1209	NC_000962.2	1353157	1353525	D	Rv1209, (MTCI364.21), len: 122 aa. Conserved hypothetical protein, containing a hydrophobic N-terminus. Similar to Q49956|U1756M hypothetical protein from Mycobacterium leprae (114 aa), FASTA scores: opt: 524, E(): 8.9e-29, (78.6% identity in 112 aa overlap).; hypothetical protein	1353157..1353525	Mycobacterium tuberculosis H37Rv	887600
NP_215726.1	CDS	tagA	NC_000962.2	1353522	1354136	D	Rv1210, (MTCI364.22), len: 204 aa. Probable tagA, DNA-3-methyladenine glycosidase I (EC 3.2.2.20) (see citation below), similar to several e.g. 3MG1_ECOLI|P05100 DNA-3-methyladenine glycosidase I from Escherichia coli (187 aa), FASTA scores: opt: 530, E(): 1.3e-27, (44.2% identity in 190 aa overlap); similar to Q49957 Mycobacterium leprae cosmid B1756 (192 aa), FASTA scores: opt: 1042, E(): 0, (80.2% identity in 192 aa overlap).; DNA-3-methyladenine glycosylase I	1353522..1354136	Mycobacterium tuberculosis H37Rv	888035
NP_215727.1	CDS	Rv1211	NC_000962.2	1354243	1354470	D	Rv1211, (MTCI364.23), len: 75 aa. Conserved hypothetical protein, similar to Q49958|U1756N Mycobacterium leprae (75 aa), FASTA scores: opt: 460, E(): 0, (90.7% identity in 75 aa overlap).; hypothetical protein	1354243..1354470	Mycobacterium tuberculosis H37Rv	887990
NP_215728.1	CDS	Rv1212c	NC_000962.2	1354498	1355661	R	Rv1212c, (MTCI364.24c), len: 387 aa. Putative glycosyl transferase (EC 2.-.-.-), highly similar to AJ243803|SCO243803_2 Putative glycosyl transferase from Streptomyces coelicolor (387 aa), FASTA scores: opt: 1344, E(): 0, (54.9% identity in 388 aa overlap). Also similar to MJ1607 probable hexosyltransferase (EC 2.4.1.-) from Methanococcus jannaschii (390 aa), FASTA scores: opt: 445, E(): 7.8e-23, (27.9% identity in 401 aa overlap). The region from aa 267-355 highly similar to Q49959 COSMID B1756 from Mycobacterium leprae (91 aa), FASTA scores, opt: 471, E(): 4.8e-25, (80.9% identity in 89 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein, Rv3032.; putative glycosyl transferase	complement(1354498..1355661)	Mycobacterium tuberculosis H37Rv	887805
NP_215729.1	CDS	glgC	NC_000962.2	1355836	1357050	D	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase	1355836..1357050	Mycobacterium tuberculosis H37Rv	887933
YP_177797.1	CDS	PE14	NC_000962.2	1357293	1357625	R	Rv1214c, (MTCI364.26c), len: 110 aa. Member of Mycobacterium tuberculosis PE family (see citation below), appears to be frameshifted but sequence appears to be correct. The 5'-end is atypical as first 9 aa appear to be missing.; PE family protein	complement(1357293..1357625)	Mycobacterium tuberculosis H37Rv	888362
NP_215731.1	CDS	Rv1215c	NC_000962.2	1357759	1359444	R	Rv1215c, (MTCI364.27c), len: 561 aa. Conserved hypothetical protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa overlap).; hypothetical protein	complement(1357759..1359444)	Mycobacterium tuberculosis H37Rv	887684
NP_215732.1	CDS	Rv1216c	NC_000962.2	1359472	1360146	R	Rv1216c, (MTCI364.28c), len: 224 aa. Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap).; integral membrane protein	complement(1359472..1360146)	Mycobacterium tuberculosis H37Rv	888125
NP_215733.1	CDS	Rv1217c	NC_000962.2	1360155	1361801	R	Rv1217c, (MTCI364.29c), len: 548 aa. Probable tetronasin-transport integral membrane ABC transporter (see citation below), similar to many e.g. AL049754|SCH10_12 probable ABC-type transport system membrane-spanning protein from Streptomyces coelicolor (539 aa), FASTA scores: opt: 1309, E(): 0, (40.9% identity in 550 aa overlap); Q54407|X73633 TnrB3 protein from Streptomyces longisporoflavus (337 aa), FASTA scores: opt: 692, E(): 0, (39.5% identity in 324 aa overlap); etc. Also has regions similar to Mycobacterium leprae proteins Q49964|U1756Q (109 aa), FASTA scores: opt: 431, E(): 3.1e-20, (64.8% identity in 105 aa overlap) and Q49965|U1756R (82 aa), FASTA scores: opt:154, E(): 0.0028, (61.0% identity in 41 aa overlap).; tetronasin-transport integral membrane protein ABC transporter	complement(1360155..1361801)	Mycobacterium tuberculosis H37Rv	888401
NP_215734.1	CDS	Rv1218c	NC_000962.2	1361798	1362733	R	Rv1218c, (MTCI61.01c), len: 311 aa. Probable tetronasin-transport ATP-binding protein ABC transporter (see citation below), similar to many e.g. Q54406|X73633|TNRB2 TNRB2 PROTEIN from Streptomyces longisporoflavus (300 aa), FASTA scores: opt: 1133, E(): 0, (60.8% identity in 291 aa overlap); etc. Also similar to others in Mycobacterium tuberculosis e.g. MTCY19H9.04 (30.0% identity in 297 aa overlap); etc. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; tetronasin-transport ATP-binding protein ABC transporter	complement(1361798..1362733)	Mycobacterium tuberculosis H37Rv	888518
NP_215735.1	CDS	Rv1219c	NC_000962.2	1362723	1363361	R	Rv1219c, (MTCI61.02c), len: 212 aa. Probable transcriptional regulatory protein, some similarity in N-terminus to YBIH_ECOLI|P41037 hypothetical transcriptional regulator from Escherichia coli (103 aa), FASTA scores: opt: 143, E(): 8.9e-06, (39.7% identity in 63 aa overlap); Helix turn helix motif from aa 28-49.; transcriptional regulatory protein	complement(1362723..1363361)	Mycobacterium tuberculosis H37Rv	888582
NP_215736.1	CDS	Rv1220c	NC_000962.2	1363503	1364150	R	Rv1220c, (MTCI61.03c), len: 215 aa. Possible methyltransferase (EC 2.1.1.-), some similarity to MDMC_STRMY|Q00719 o-methyltransferase from Streptomyces mycarofaciens (221 aa), FASTA scores; opt: 289, E(): 1.3e-07, (30.0% identity in 203 aa overlap). Also similar to Mycobacterium tuberculosis methyltransferases Rv0187|MTCI28.26 (32.9% identity in 222 aa overlap) and Rv1703c. Start site chosen by homology; other possible start sites exist upstream.; methyltransferase	complement(1363503..1364150)	Mycobacterium tuberculosis H37Rv	888419
NP_215737.1	CDS	sigE	NC_000962.2	1364413	1365186	D	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE	1364413..1365186	Mycobacterium tuberculosis H37Rv	888751
NP_215738.1	CDS	Rv1222	NC_000962.2	1365344	1365808	D	Rv1222, (MTCI61.05), len: 154 aa. Conserved hypothetical protein. Identical to O06290|MTU87242 (but shorter due to different start site chosen by proximity of RBS). Equivalent to O05736|U87308|MAU87308_2 hypothetical protein from Mycobacterium avium (133 aa), FASTA scores: opt: 644, E(): 7e-32, (86.2% identity in 109 aa overlap).; hypothetical protein	1365344..1365808	Mycobacterium tuberculosis H37Rv	885196
NP_215739.2	CDS	htrA	NC_000962.2	1365875	1367461	D	Rv1223, (MTCI61.06), len: 528 aa. Probable htrA (alternate gene name: degP), serine protease precursor (EC 3.4.21.-) (see citations below), equivalent to U15180|MLU15180_31|Q49972|ML1078|HTRA POSSIBLE SERINE PROTEASE from Mycobacterium leprae (533 aa), FASTA scores: opt: 2777, E(): 4.1e-141, (81.6% identity in 533 aa overlap). Also similar to many others e.g. HTRA_ECOLI|P09376 protease do precursor from Escherichia coli (EC 3.4.21.-) (474 aa), FASTA scores: opt: 581, E(): 9.1e-27, (36.3% identity in 278 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Start changed since first submission (-21 aa).; degP; serine protease HtrA	1365875..1367461	Mycobacterium tuberculosis H37Rv	888912
NP_215740.1	CDS	tatB	NC_000962.2	1367463	1367858	D	mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase	1367463..1367858	Mycobacterium tuberculosis H37Rv	887143
NP_215741.1	CDS	Rv1225c	NC_000962.2	1367891	1368721	R	Rv1225c, (MTCI61.08c), len: 276 aa. Conserved hypothetical protein, some similarity to other hypothetical proteins e.g. AE001078|AE001078_2 Archaeoglobus fulgidus (265 aa), FASTA scores: opt: 339, E(): 5.1e-15, (27.1% identity in 262 aa overlap), and to NAGD_ECOLI|P15302 nagd protein from Escherichia coli (250 aa), FASTA scores: opt: 167, E(): 6.4e-12, (24.8% identity in 258 aa overlap). Also weakly similar to Mycobacterium tuberculosis hypothetical protein Rv3400|MTCY78.28c (29.1% identity in 251 aa overlap).; hypothetical protein	complement(1367891..1368721)	Mycobacterium tuberculosis H37Rv	887148
NP_215742.1	CDS	Rv1226c	NC_000962.2	1368832	1370295	R	Rv1226c, (MTCI61.09c), len: 487 aa. Probable transmembrane protein. Some similarity to AL049841|SCE9.01 Streptomyces coelicolor (436 aa), FASTA scores: opt: 203, E(): 1.2e-05, (29.8% identity in 346 aa overlap).; hypothetical protein	complement(1368832..1370295)	Mycobacterium tuberculosis H37Rv	887144
NP_215743.1	CDS	Rv1227c	NC_000962.2	1370292	1370825	R	Rv1227c, (MTCI61.10c), len: 177 aa. Possible transmembrane protein, similar to P96615 hypothetical protein ydbS from Bacillus subtilis (159 aa), fasta scores: E(): 3.6e-07, (30.1% identity in 163 aa overlap).; hypothetical protein	complement(1370292..1370825)	Mycobacterium tuberculosis H37Rv	885872
NP_215744.1	CDS	lpqX	NC_000962.2	1370920	1371477	D	Rv1228, (MTCI61.11), len: 185 aa. Probable lipoprotein LpqX. Contains possible signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LpqX	1370920..1371477	Mycobacterium tuberculosis H37Rv	886013
NP_215745.1	CDS	mrp	NC_000962.2	1371777	1372949	R	Rv1229c, (MT1267, MTCI61.12c, MTV006.01c), len: 390 aa. Probable Mrp protein, similar to others e.g. MRP_ECOLI|P21590 mrp protein from Escherichia coli (379 aa), FASTA scores: E(): 0, (34.1% identity in 355 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); and PS01215 MRP Prosite domain. BELONGS TO THE MRP/NBP35 FAMILY OF ATP-BINDING PROTEINS.; MRP family ATP-binding protein	complement(1371777..1372949)	Mycobacterium tuberculosis H37Rv	886067
NP_215746.1	CDS	Rv1230c	NC_000962.2	1372962	1374197	R	Rv1230c, (MTV006.02c), len: 411 aa. Possible membrane protein with two hydrophobic stretches near N-terminus. Some similarity to Rv1022|MTCY10G2.27c|Z92539 probable lpqU protein Mycobacterium tuberculosis (243 aa), FASTA score: opt: 408, E(): 1e-11, (43.6% identity in 172 aa overlap). Similar to AL133423|SC4A7.37 hypothetical protein from Streptomyces coelicolor (421 aa), FASTA score: opt: 679, E(): 5.1e-23, (36.4% identity in 398 aa overlap). TBparse score is 0.917.; hypothetical protein	complement(1372962..1374197)	Mycobacterium tuberculosis H37Rv	887134
NP_215747.1	CDS	Rv1231c	NC_000962.2	1374322	1374864	R	Rv1231c, (MTV006.03c), len: 180 aa. Probable membrane protein, similar to others e.g. AL390975 Streptomyces coelicolor (198 aa). TBparse score is 0.885.; hypothetical protein	complement(1374322..1374864)	Mycobacterium tuberculosis H37Rv	887140
NP_215748.1	CDS	Rv1232c	NC_000962.2	1374861	1376168	R	Rv1232c, (MTV006.04c), len: 435 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. AB013374|AB013374_2 Bacillus halodurans C-125 mamX (449 aa), FASTA scores: opt: 381, E(): 1e-16, (29.9% identity in 251 aa overlap). Some similarity in N-terminus to U15180|MLU1518033 hypothetical Mycobacterium leprae protein u1756u (329 aa), FASTA scores: opt: 300, E(): 4.1e-12, (69.3% identity in 75 aa overlap). TBparse score is 0.905.; hypothetical protein	complement(1374861..1376168)	Mycobacterium tuberculosis H37Rv	886014
NP_215749.1	CDS	Rv1233c	NC_000962.2	1376230	1376826	R	Rv1233c, (MTV006.05c), len: 198 aa. Conserved hypothetical membrane protein, N-terminus is highly proline rich, C-terminus has two hydrophobic stretches. Proline-rich N-terminus has some similarity to CBPA_DICDI calcium binding protein from Dictyostelium discoideum (467 aa), FASTA scores: E(): 4.8e-06, (35.5% identity in 183 aa overlap). Both sequences share multiple copies of a Tyr-Pro-Pro motif.; hypothetical protein	complement(1376230..1376826)	Mycobacterium tuberculosis H37Rv	887131
NP_215750.1	CDS	Rv1234	NC_000962.2	1376976	1377503	D	Rv1234, (MTV006.06), len: 175 aa. Possible transmembrane protein with two TM helices. TBparse score is 0.929.; hypothetical protein	1376976..1377503	Mycobacterium tuberculosis H37Rv	887137
NP_215751.1	CDS	lpqY	NC_000962.2	1377524	1378930	D	Rv1235, (MTV006.07), len: 468 aa. Probable lpqY, sugar-binding lipoprotein component of sugar transport system (see citation below), equivalent to MLU1518034 protein u1756v from Mycobacterium leprae (469 aa), FASTA scores: opt: 2442, E(): 0, (77.4% identity in 470 aa overlap). Also similar to P18815|MALE_ENTAE MALTOSE-BINDING PERIPLASMIC PROTEIN from Enterobacter aerogenes (396 aa), FASTA scores: opt: 193, E(): 2.3e-05, (24.2% identity in 297 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.914.; sugar-binding lipoprotein LpqY	1377524..1378930	Mycobacterium tuberculosis H37Rv	887145
NP_215752.1	CDS	sugA	NC_000962.2	1378927	1379850	D	Rv1236, (MTV006.08), len: 307 aa. Probable sugA, sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to U15180|MLU1518035 protein malFM from Mycobacterium leprae (310 aa), FASTA scores: opt: 1566, E(): 0, (81.8% identity in 292 aa overlap). Also similar to numerous bacterial sugar transport system components. Also similar to Rv2316|MTCY3G12.18c from Mycobacterium tuberculosis (290 aa), FASTA scores: opt: 514, E(): 7.3e-27, (33.2% identity in 283 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. TBparse score is 0.899.; sugar-transport integral membrane protein ABC transporter SugA	1378927..1379850	Mycobacterium tuberculosis H37Rv	887124
NP_215753.1	CDS	sugB	NC_000962.2	1379855	1380679	D	Rv1237, (MTV006.09), len: 274 aa. Probable sugB, sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to U15180|MLU1518036 protein MalGM from Mycobacterium leprae (296 aa), FASTA scores: opt: 1571, E(): 0, (89.8% identity in 274 aa overlap). Also similar to numerous bacterial sugar transport protein. Related to Rv2834c|MTCY16B7.08 from Mycobacterium tuberculosis (275 aa), FASTA scores: opt: 370, E(): 2.4e-17, (26.8% identity in 269 aa overlap). TBparse score is 0.895.; sugar-transport integral membrane protein ABC transporter SugB	1379855..1380679	Mycobacterium tuberculosis H37Rv	887121
NP_215754.1	CDS	sugC	NC_000962.2	1380684	1381865	D	Rv1238, (MTV006.10), len: 393 aa. Probable sugC, sugar-transport ATP-binding protein ABC transporter (see citation below). Highly similar to U15180 protein ugpC from Mycobacterium leprae (392 aa), FASTA score: opt: 2007, E(): 0, (79.9% identity in 389 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.920.; sugar-transport ATP-binding protein ABC transporter SugC	1380684..1381865	Mycobacterium tuberculosis H37Rv	887104
NP_215755.1	CDS	corA	NC_000962.2	1381942	1383042	R	Rv1239c, (MTV006.11c), len: 366 aa. Possible corA, magnesium and cobalt transport transmembrane protein, highly similar to U15180 corA protein from Mycobacterium leprae (373 aa), FASTA scores: opt: 1985, E(): 0, (79.1% identity in 369 aa overlap). Also similar to various CorA proteins of Gram negative bacteria e.g. P27841|CORA_ECOLI|B3816|Z5333|ECS4746 Magnesium and cobalt transport protein from Escherichia coli strains K12 and O157:H7 (316 aa), FASTA scores: opt: 236, E(): 8e-08, (24.5% identity in 306 aa overlap); etc. SEEMS TO BELONG TO THE MIT FAMILY. TBparse score is 0.902.; magnesium/cobalt transporter CorA	complement(1381942..1383042)	Mycobacterium tuberculosis H37Rv	887106
NP_215756.1	CDS	mdh	NC_000962.2	1383213	1384202	D	catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase	1383213..1384202	Mycobacterium tuberculosis H37Rv	887119
NP_215757.1	CDS	Rv1241	NC_000962.2	1384278	1384538	D	Rv1241, (MTV006.13), len: 86 aa. Conserved hypothetical protein, member of family of 16 hypothetical Mycobacterium tuberculosis proteins including: Rv2871|Q10799|YS71_MYCTU HYPOTHETICAL 13.2 kDa PROTEIN CY2 (124 aa), FASTA scores: opt: 172, E(): 9.5e-06, (37.2% identity in 86 aa overlap); Rv2132, Rv3321c, etc. TBparse score is 0.875.; hypothetical protein	1384278..1384538	Mycobacterium tuberculosis H37Rv	887118
NP_215758.1	CDS	Rv1242	NC_000962.2	1384535	1384966	D	Rv1242, (MTV006.14), len: 143 aa. Conserved hypothetical protein, member of family of 14 hypothetical Mycobacterium tuberculosis proteins including: Rv2872|Q10800|YS72_MYCTU (147 aa), FASTA scores: opt: 226, E(): 2.7e-09, (32.1% identity in 137 aa overlap); Rv0749, Rv0277c, Rv2530c, etc. TBparse score is 0.893.; hypothetical protein	1384535..1384966	Mycobacterium tuberculosis H37Rv	887095
YP_177798.1	CDS	PE_PGRS23	NC_000962.2	1384989	1386677	R	Rv1243c, (MTV006.15c), len: 562 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). TBparse score is 0.875.; PE-PGRS family protein	complement(1384989..1386677)	Mycobacterium tuberculosis H37Rv	887109
NP_215760.1	CDS	lpqZ	NC_000962.2	1386857	1387717	D	Rv1244, (MTV006.16), len: 286 aa. Probable lipoprotein lpqZ, equivalent toU15180|MLU1518042 protein u1756x from Mycobacterium leprae (228 aa), FASTA scores: opt: 1039, E(): 0, (72.5% identity in 229 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein Rv3759c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.878.; lipoprotein LpqZ	1386857..1387717	Mycobacterium tuberculosis H37Rv	887093
NP_215761.1	CDS	Rv1245c	NC_000962.2	1387798	1388628	R	Rv1245c, (MTV006.17c), len: 276 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), equivalent to NP_301801.1|NC_002677 short chain alcohol dehydrogenase from Mycobacterium leprae (277 aa). Also highly similar to various dehydrogenases and oxidoreductases e.g. NP_250228.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (295 aa); NP_421969.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (278 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv3085|MTV013.06 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE (276 aa), FASTA scores: opt: 368, E(): 1.2e-16, (35.3% identity in 224 aa overlap); Rv3057c|MTCY22D7.24 PUTATIVE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE (287 aa), FASTA scores: opt: 471, E(): 1.3e-21, (32.4% identity in 281 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is 0.871.; short-chain type dehydrogenase/reductase	complement(1387798..1388628)	Mycobacterium tuberculosis H37Rv	887091
NP_215762.1	CDS	Rv1246c	NC_000962.2	1388685	1388978	R	Rv1246c, (MTV006.18c), len: 97 aa. Conserved hypothetical protein, highly similar to Rv2866|MTV003.12 hypothetical Mycobacterium tuberculosis protein (87 aa), FASTA scores: opt: 290, E(): 3.9e-24, (54.1% identity in 85 aa overlap).; hypothetical protein	complement(1388685..1388978)	Mycobacterium tuberculosis H37Rv	887099
NP_215763.1	CDS	Rv1247c	NC_000962.2	1388975	1389244	R	Rv1247c, (MTV006.19c), len: 89 aa. Conserved hypothetical protein, some similarity to hypothetical proteins including Mycobacterium tuberculosis proteins Rv2865|MTV003.11 (93 aa), FASTA scores: opt: 249, E(): 5.4e-13, (44.2% identity in 86 aa overlap); Rv0268|Z86089|P95225 (169 aa) opt: 125, E(): 0.0089, (41.8% identity in 55 aa overlap); etc. and Escherichia coli AE000293|ECAE0002933 (92 aa), FASTA scores: opt: 127, E(): 0.0038, (29.3% identity in 82 aa overlap). TBparse score is 0.905.; hypothetical protein	complement(1388975..1389244)	Mycobacterium tuberculosis H37Rv	887086
NP_215764.2	CDS	kgd	NC_000962.2	1389357	1393052	R	kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase	complement(1389357..1393052)	Mycobacterium tuberculosis H37Rv	887084
NP_215765.1	CDS	Rv1249c	NC_000962.2	1393194	1393982	R	Rv1249c, (MTV006.21c), len: 262 aa. Possible membrane protein. Start uncertain. TBparse score is 0.899.; hypothetical protein	complement(1393194..1393982)	Mycobacterium tuberculosis H37Rv	887077
NP_215766.1	CDS	Rv1250	NC_000962.2	1394179	1395918	D	Rv1250, (MTV006.22), len: 579 aa. Probable drug-transport integral membrane protein, member of major facilitator superfamily (MFS), highly similar to several including P39886|TCMA_STRGA TETRACENOMYCIN C RESISTANCE PROTEIN from Streptomyces glaucescens (538 aa), FASTA scores: opt: 847, E(): 0, (32.9% identity in 517 aa overlap); etc. Also similar to MTCY20B11.14c|Rv3239C from Mycobacterium tuberculosis (1048 aa), FASTA scores: opt: 629, E(): 6.7e-13, (31.9% identity in 423 aa overlap). TBparse score is 0.921.; drug-transport integral membrane protein	1394179..1395918	Mycobacterium tuberculosis H37Rv	887073
NP_215767.1	CDS	Rv1251c	NC_000962.2	1395821	1399240	R	Rv1251c, (MTV006.23c), len: 1139 aa. Conserved hypothetical protein, showing some similarity in C-terminal region with other proteins from eukaryotes and bacteria e.g. NP_142121.1 hypothetical protein from Pyrococcus horikoshii (1188 aa); and some similarity to GTP-binding proteins e.g. P23249|MV10_MOUSE PUTATIVE GTP-BINDING PROTEIN (1004 aa), FASTA scores: opt: 228, E(): 1.7e-06, (27.7% identity in 560 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.906.; hypothetical protein	complement(1395821..1399240)	Mycobacterium tuberculosis H37Rv	887080
NP_215768.1	CDS	lprE	NC_000962.2	1399296	1399904	R	Rv1252c, (MTCY50.30), len: 202 aa. Probable lipoprotein lprE, some similarity to Mycobacterium tuberculosis protein Rv3483c|MTCY13E12.36C (220 aa), FASTA scores: E(): 7e-05, (29.5% identity in 200 aa overlap). Contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013).; lipoprotein LprE	complement(1399296..1399904)	Mycobacterium tuberculosis H37Rv	887064
NP_215769.1	CDS	deaD	NC_000962.2	1399970	1401661	D	Rv1253, (MTCY50.29c), len: 563 aa. Probable Dead, Cold-shock DEAD-box protein A homolog, similar to many e.g. DEAD_ECOLI|P23304 Escherichia coli (646 aa), FASTA scores: opt: 1490, E(): 0, (46.7% identity in 578 aa overlap); similar to Mycobacterium tuberculosis Rv3211. Contains PS00017 ATP/GTP-binding site motif A, PS00039 DEAD-box subfamily ATP-dependent helicases signature. BELONGS TO THE DEAD BOX FAMILY HELICASE.; cold-shock DEAD-box protein A	1399970..1401661	Mycobacterium tuberculosis H37Rv	887069
NP_215770.1	CDS	Rv1254	NC_000962.2	1401658	1402809	D	Rv1254, (MTCY50.28c), len: 383 aa. Probable Acyltransferase (EC 2.3.1.-), similar to G927228 midecamycin 4-0-propionyl transferase (fragment) (388 aa), FASTA scores, opt: 305, E(): 5.6e-14, (28.4% identity in 377 aa overlap). Also similar to other Mycobacterium tuberculosis acyltransferases e.g. Rv0111, Rv0228, etc. Contains PS00881 Protein splicing signature.; acyltransferase	1401658..1402809	Mycobacterium tuberculosis H37Rv	887076
NP_215771.1	CDS	Rv1255c	NC_000962.2	1402778	1403386	R	Rv1255c, (MTCY50.27), len: 202 aa. Possible regulatory protein, similar to others e.g. ACRR_ECOLI|P34000 potential acrab operon repressor from E. coli (215 aa), FASTA scores: opt: 128, E(): 0.25, (42.1% identity in 57 aa overlap). Helix turn helix motif present at aa 36-57 (+5.48 SD).; transcriptional regulatory protein	complement(1402778..1403386)	Mycobacterium tuberculosis H37Rv	887068
NP_215772.1	CDS	cyp130	NC_000962.2	1403386	1404603	R	Rv1256c, (MT1295, MTCY50.26), len: 405 aa. Probable cyp130, cytochrome P450 (EC 1.14.-.-), similar to other cytochromes P-450 e.g. S51594 cytochrome P450 mycG from Micromonospora griseorubida (397 aa); T36526 probable cytochrome P450 hydroxylase from Streptomyces coelicolor (411 aa); CPXK_SACER|P33271|107B1 CYTOCHROME P450 from Saccharopolyspora erythraea (405 aa), FASTA scores: opt: 639, E(): 2.7e-33, (33.2% identity in 391 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0766c|MTCY369.11c CYTOCHROME P450 (402 aa); etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.; cytochrome P450 130 CYP130	complement(1403386..1404603)	Mycobacterium tuberculosis H37Rv	887059
NP_215773.1	CDS	Rv1257c	NC_000962.2	1404717	1406084	R	Rv1257c, (MTCY50.25), len: 455 aa. Probable oxidoreductase (EC 1.-.-.-), similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c; oxidoreductase	complement(1404717..1406084)	Mycobacterium tuberculosis H37Rv	887063
NP_215774.1	CDS	Rv1258c	NC_000962.2	1406081	1407340	R	Rv1258c, MTCY50.24, len: 419 aa. Probable conserved integral membrane transport (efflux) protein, possibly member of major facilitator superfamily (MFS), highly similar to O32859|TAP PROTEIN multidrug-resistance efflux pump from Mycobacterium fortuitum (409 aa), FASTA scores: E(): 0, (68.4% identity in 408 aa overlap). Contains PS00216 Sugar transport proteins signature 1.; integral membrane transport protein	complement(1406081..1407340)	Mycobacterium tuberculosis H37Rv	887056
NP_215775.1	CDS	Rv1259	NC_000962.2	1407339	1408238	D	Rv1259, (MTCY50.23c), len: 299 aa. Conserved hypothetical protein. Similar to AL109732|SC7H2.04 hypothetical protein from Streptomyces coelicolor (237 aa), FASTA scores: opt: 870, E(): 0, (57.1% identity in 231 aa overlap).; hypothetical protein	1407339..1408238	Mycobacterium tuberculosis H37Rv	887047
NP_215776.1	CDS	Rv1260	NC_000962.2	1408240	1409358	D	Rv1260, (MTCY50.22c), len: 372 aa. Probable oxidoreductase (EC 1.-.-.-), highly similar to E1245747|AL021411 putative oxidoreductase SC7H1.18 from Streptomyces coelicolor (397 aa), FASTA scores: E(): 1.4e-29, (45.9% identity in 355 aa overlap); also some similarity to G912582 FAD binding protein homologue from Pseudomonas aeruginosa (286 aa), FASTA scores: opt: 245, E(): 2e-09, (27.5% identity in 251 aa overlap); PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537 aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity in 360 aa overlap); TETX_BACFR|Q01911 tetracycline resistance protein (388 aa), FASTA scores: opt: 183, E(): 3e-05, (22.8% identity in 373 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0575c and Rv1751.; hypothetical protein	1408240..1409358	Mycobacterium tuberculosis H37Rv	887044
NP_215777.1	CDS	Rv1261c	NC_000962.2	1409484	1409933	R	Rv1261c, (MTCY50.21), len: 149 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1558|MTCY48.07c (39.2% identity in 125 aa overlap); Rv3547 and Rv3178.; hypothetical protein	complement(1409484..1409933)	Mycobacterium tuberculosis H37Rv	887055
NP_215778.1	CDS	Rv1262c	NC_000962.2	1409938	1410372	R	Rv1262c, (MTCY50.20), len: 144 aa. Hypothetical HIT-like protein, similar to Q04344|HIT_YEAST hit1 protein (orf u) (144 aa), FASTA scores: opt: 306, E(): 3e-14, (35.9 % identity in 142 aa overlap); also similar to YHIT_MYCGE|P47378 hypothetical 15.6 kDa protein (141 aa), FASTA scores: opt: 250, E(): 1.6e-10, (35.5% identity in 107 aa overlap); and YHIT_MYCLE|P49774 hypothetical 17.0 kDa protein hit-like (155 aa), FASTA scores: opt: 196, E(): 7e-07, (30.6% identity in 144 aa overlap). Similar to other proteins from Mycobacterium tuberculosis e.g. Rv2613c, Rv0759c. Contains PS00892 HIT family signature. BELONGS TO THE HIT FAMILY.; HIT-like protein	complement(1409938..1410372)	Mycobacterium tuberculosis H37Rv	887036
NP_215779.1	CDS	amiB2	NC_000962.2	1410431	1411819	D	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase	1410431..1411819	Mycobacterium tuberculosis H37Rv	887041
NP_215780.1	CDS	Rv1264	NC_000962.2	1411894	1413087	D	Rv1264, (MTCY50.18c), len: 397 aa. Adenylate cyclase (EC 4.6.1.1) (function proven experimentally: see Linder et al., 2002), showing some similarity to other adenylate cyclases e.g. CYAA_BRELI|P27580 (403 aa), FASTA scores, opt: 270, E(): 1.3e-10, (29.3% identity in 317 aa overlap); etc. Similar to other putative cyclases in M. tuberculosis e.g. Rv2212, Rv1647. The C terminus seems to code for a catalytic domain belonging to a subfamily of adenylyl cyclase isozymes (mostly found in Gram-positive bacteria). The N terminus seems to be a potential novel regulator of adenylyl cyclase activity (autoinhibitory domain). BELONGS TO THE ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY.; adenylyl cyclase	1411894..1413087	Mycobacterium tuberculosis H37Rv	887035
NP_215781.1	CDS	Rv1265	NC_000962.2	1413260	1413940	D	Rv1265, (MTCY50.17c), len: 226 aa. Hypothetical unknown protein (see citation below).; hypothetical protein	1413260..1413940	Mycobacterium tuberculosis H37Rv	887058
NP_215782.1	CDS	pknH	NC_000962.2	1413960	1415840	R	Rv1266c, (MTCY50.16), len: 626 aa. Probable pknH, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to many e.g. PKN1_MYXXA|P33973 pkn1 (693 aa), FASTA scores: opt: 611, E(): 1.4e- 14, (29.7% identity in 492 aa overlap); etc. Contains PS00107 Protein kinases ATP-binding region signature; PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation.; transmembrane serine/threonine-protein kinase H	complement(1413960..1415840)	Mycobacterium tuberculosis H37Rv	887023
NP_215783.1	CDS	embR	NC_000962.2	1416181	1417347	R	Rv1267c, (MT1305, MTCY50.15), len: 388 aa. Probable embR, regulatory protein (see citation below), similar to many e.g. AFSR_STRCO|P25941 regulatory protein AfsR from Streptomyces coelicolor (993 aa), FASTA scores: opt: 489, E(): 1e-25, (33.5% identity in 361 aa overlap); etc. BELONGS TO THE AFSR/DNRI/REDD FAMILY OF REGULATORS.; transcriptional regulatory protein EMBR	complement(1416181..1417347)	Mycobacterium tuberculosis H37Rv	887026
NP_215784.1	CDS	Rv1268c	NC_000962.2	1417658	1418356	R	Rv1268c, (MTCY50.14), len: 232 aa. Hypothetical unknown protein, probably secreted protein : contains possible signal peptide sequence (score 7.9 at residue 28).; hypothetical protein	complement(1417658..1418356)	Mycobacterium tuberculosis H37Rv	887033
NP_215785.1	CDS	Rv1269c	NC_000962.2	1418579	1418953	R	Rv1269c, (MTCY50.13), len: 124 aa. Conserved probable exported protein with putative N-terminal signal sequence. Similar to Mycobacterium tuberculosis protein Rv1813c|Y0DU_MYCTU|Q50620 hypothetical protein cy1a11.30 (137 aa), FASTA scores: E(): 9e-21, (41.6% identity in 137 aa overlap).; hypothetical protein	complement(1418579..1418953)	Mycobacterium tuberculosis H37Rv	887039
NP_215786.1	CDS	lprA	NC_000962.2	1419014	1419748	R	Rv1270c, (MTCY50.12), len: 244 aa. Possible lprA, lipoprotein. Similar to O32852|AJ000500 lipoprotein from Mycobacterium bovis (236 aa), fasta scores: E(): 5.2e-23, (35.1% identity in 245 aa overlap). Similar to M. tuberculosis lipoproteins: Rv1368, Rv1411c, Rv2945c. Contains probable N-terminal signal sequence.; lipoprotein LprA	complement(1419014..1419748)	Mycobacterium tuberculosis H37Rv	887017
NP_215787.1	CDS	Rv1271c	NC_000962.2	1419961	1420302	R	Rv1271c, (MTCY50.11), len: 113 aa. Conserved hypothetical exported protein with potential N-terminal signal sequence. Similar to Mycobacterium tuberculosis hypothetical proteins Rv1804c, Rv1810, Rv0622, etc.; hypothetical protein	complement(1419961..1420302)	Mycobacterium tuberculosis H37Rv	887019
NP_215788.1	CDS	Rv1272c	NC_000962.2	1420410	1422305	R	Rv1272c, (MTCY50.10), len: 631 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below), similar to e.g. Y015_MYCGE|P47261 hypothetical ABC transporter mg015m from Mycoplasma genitalium (589 aa), FASTA scores: opt: 1054, E(): 0, (34.3% identity in 522 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop); and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS), MSBA SUBFAMILY.; drugs-transport transmembrane ATP-binding protein ABC transporter	complement(1420410..1422305)	Mycobacterium tuberculosis H37Rv	887021
NP_215789.1	CDS	Rv1273c	NC_000962.2	1422302	1424050	R	Rv1273c, (MTCY50.09), len: 582 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below), similar to e.g. YWJA_BACSU|P45861 hypothetical abc transporter from B. subtilis (575 aa), FASTA scores: opt: 810, E(): 0, (27.0% identity in 578 aa overlap); etc. Contains PS00136 Serine proteases, subtilase family, aspartic acid active site; 2 x PS00211 ABC transporters family signature; and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS), MSBA SUBFAMILY.; drugs-transport transmembrane ATP-binding protein ABC transporter	complement(1422302..1424050)	Mycobacterium tuberculosis H37Rv	887025
NP_215790.1	CDS	lprB	NC_000962.2	1424197	1424754	D	Rv1274, (MTCY50.08c), len: 185 aa. Possible lprB, lipoprotein; contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013) . Some similarity to Rv1275.; lipoprotein LprB	1424197..1424754	Mycobacterium tuberculosis H37Rv	887011
NP_215791.1	CDS	lprC	NC_000962.2	1424751	1425293	D	Rv1275, (MTCY50.07c), len: 180 aa. Possible lprC, lipoprotein; contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Some similarity to Rv1274.; lipoprotein LprC	1424751..1425293	Mycobacterium tuberculosis H37Rv	887014
NP_215792.1	CDS	Rv1276c	NC_000962.2	1425438	1425914	R	Rv1276c, (MTCY50.06), len: 158 aa. Conserved hypothetical protein, similar to AL096844|SCI28.03 hypothetical protein from Streptomyces coelicolor (172 aa), FASTA scores: opt: 385, E(): 3.3e-19, (43.5% identity in 161 aa overlap). Some similarity to P76502|SIXA_ECOLI PHOSPHOHISTIDINE PHOSPHATASE SIXA (161 aa), FASTA scores: opt: 146, E(): 0.0047, (31.9% identity in 116 aa overlap). BELONGS TO THE SIXA FAMILY OF PHOSPHATASES.; hypothetical protein	complement(1425438..1425914)	Mycobacterium tuberculosis H37Rv	887000
NP_215793.1	CDS	Rv1277	NC_000962.2	1426164	1427417	D	Rv1277, (MTCY50.05c), len: 417 aa. Conserved hypothetical protein, some similarity to 3914967|O68033|SBCD_RHOCA EXONUCLEASE SBCD HOMOLOG from Rhodobacter capsulatus (405 aa). May be sbcD protein (see Mizrahi & Andersen 1998); hypothetical protein	1426164..1427417	Mycobacterium tuberculosis H37Rv	887001
NP_215794.1	CDS	Rv1278	NC_000962.2	1427414	1430041	D	Rv1278, (MTCY50.04c), len: 875. Hypothetical unknown protein, possible coiled-coil regions, contains PS00017 ATP/GTP-binding site motif A.; hypothetical protein	1427414..1430041	Mycobacterium tuberculosis H37Rv	887005
NP_215795.1	CDS	Rv1279	NC_000962.2	1430062	1431648	D	Rv1279, (MTCY50.03c), len: 528 aa. Probable dehydrogenase, FAD flavoprotein GMC oxidoreductase (EC 1.1.-.-), similar to several e.g. dBETA_ECOLI|P17444 choline dehydrogenase from Escherichia coli (556 aa), FASTA scores, opt: 1047, E(): 0, (37.7% identity in 541 aa overlap). Similar to Rv0697 putative Mycobacterium tuberculosis GMC oxidoreductase. Contains PS00623 GMC oxidoreductases signature 1, and PS00624 GMC oxidoreductases signature 2. BELONGS TO THE GMC OXIDOREDUCTASES FAMILY.; dehydrogenase FAD flavoprotein GMC oxidoreductase	1430062..1431648	Mycobacterium tuberculosis H37Rv	887002
NP_215796.1	CDS	oppA	NC_000962.2	1431665	1433440	R	Rv1280c, (MTCY50.02), len: 591 aa. Probable oppA, oligopeptide-binding lipoprotein component of peptide transport system (see citation below), sharing some similarity to other periplasmic solute binding proteins e.g. OPPA_SALTY|P06202 periplasmic oligopeptide-binding protein from Salmonella typhimurium (542 aa), FASTA scores: E(): 5.1e-05, (22.1% identity in 458 aa overlap); etc. Also similar to Rv1166 and Rv2585c from Mycobacterium tuberculosis. Has possible N-terminal signal sequence and prokaryotic lipoprotein lipid attachment site (PS00013). BELONGS TO THE BACTERIAL EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 5.; periplasmic oligopeptide-binding lipoprotein OppA	complement(1431665..1433440)	Mycobacterium tuberculosis H37Rv	886985
NP_215797.1	CDS	oppD	NC_000962.2	1433433	1435271	R	Rv1281c, (MTCY50.01), len: 612 aa. Probable oppD, oligopeptide-transport ATP-binding protein ABC transporter (see citation below), similar to others e.g. DPPD_BACSU|P26905 dipeptide transport ATP-binding protein from Bacillus subtilis (335 aa), FASTA scores: opt: 983, E(): 0, (48.6% identity in 319 aa overlap); etc. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); 2 x PS00211 ABC transporters family signature.BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; oligopeptide-transport ATP-binding protein ABC transporter OppD	complement(1433433..1435271)	Mycobacterium tuberculosis H37Rv	886997
NP_215798.1	CDS	oppC	NC_000962.2	1435268	1436143	R	Rv1282c, (MTCY373.01c-MTCY3H3.01), len: 291 aa. Probable oppC, oligopeptide-transport integral membrane protein ABC transporter (see citation below), similar to other integral membrane proteins e.g. OPPC_ECOLI|P77664 oligopeptide transport system permease from Escherichia coli (302 aa), FASTA scores: E(): 4.6e-33, (40.7% identity in 275 aa overlap); etc. Also similar to Rv3664c|DPPC probable peptide-transport integral membrane protein from Mycobacterium tuberculosis.; oligopeptide-transport integral membrane protein ABC transporter OppC	complement(1435268..1436143)	Mycobacterium tuberculosis H37Rv	886980
NP_215799.1	CDS	oppB	NC_000962.2	1436140	1437117	R	Rv1283c, (MTCY373.02c), len: 325 aa. Probable oppB, oligopeptide-transport integral membrane protein ABC transporter (see citation below), similar to other integral membrane proteins e.g. DPPB_ECOLI|P37316 dipeptide transport system permease protein from Escherichia coli (339 aa), FASTA scores: opt: 402, E(): 3.4e-20, (31.0% identity in 345 aa overlap); etc. Also similar to Rv3665c|DppB probable peptide-transport integral membrane protein from Mycobacterium tuberculosis. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.; oligopeptide-transport integral membrane protein ABC transporter OppB	complement(1436140..1437117)	Mycobacterium tuberculosis H37Rv	886981
NP_215800.1	CDS	Rv1284	NC_000962.2	1437324	1437815	D	Rv1284, (MTCY373.03), len: 163 aa. Conserved hypothetical protein, similar to AL109663|SC4A10.26 hypothetical protein from Streptomyces coelicolor (167 aa), FASTA scores: opt: 567, E(): 1.5e-32, (53.4% identity in 163 aa overla); shows some similarity to hypothetical protein from Methanobacterium thermoautotrophicum. Weak similarity to carbonic anhydrases e.g. U51624|MTU516242|P17582 Methanothermobacter thermautotrophicus (171 aa), FASTA score: opt: 305, E(): 1 .2e-14, (35.2% identity in 165 aa overlap).; hypothetical protein	1437324..1437815	Mycobacterium tuberculosis H37Rv	886987
NP_215801.1	CDS	cysD	NC_000962.2	1437909	1438907	D	with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2	1437909..1438907	Mycobacterium tuberculosis H37Rv	886979
NP_215802.1	CDS	cysN	NC_000962.2	1438907	1440751	D	in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein	1438907..1440751	Mycobacterium tuberculosis H37Rv	886978
NP_215803.1	CDS	Rv1287	NC_000962.2	1440805	1441290	D	Rv1287, (MTCY373.06), len: 161 aa. Conserved hypothetical protein, similar to VJEB family of proteins e.g. FASTA score: P44675|Y379_HAEIN HYPOTHETICAL PROTEIN HI0379 (150 aa), FASTA scores: opt: 213, E(): 2.5e-08, (30.0% identity in 130 aa overlap) and YJEB_ECOLI|P21498 hypothetical 15.6 kDa protein in pura-vacb (141 aa), opt: 167, E(): 9.5e-06, (25.0% identity in 136 aa overlap). BELONGS TO THE UPF0074 (RFF2) FAMILY.; hypothetical protein	1440805..1441290	Mycobacterium tuberculosis H37Rv	886998
NP_215804.1	CDS	Rv1288	NC_000962.2	1441348	1442718	D	Rv1288, (MTCY373.07), len: 456 aa. Conserved hypothetical protein, some similarity to A85B_MYCTU|P31952 antigen 85-b precursor (85b) (325 aa), FASTA scores: opt: 199, E(): 2.7e-06, (24.7% identity in 279 aa overlap). Also similar to Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (related to antigen 85 complex) from Corynebacterium glutamicum (657 aa), FASTA scores: opt: 280, E(): 1.9e-10, (26.4% identity in 352 aa overlap). SEEMS TO CONTAIN 3 LYSM REPEATS; hypothetical protein	1441348..1442718	Mycobacterium tuberculosis H37Rv	886974
NP_215805.1	CDS	Rv1289	NC_000962.2	1442767	1443399	D	Rv1289, (MTCY373.08), len: 210 aa. Hypothetical unknown protein.; hypothetical protein	1442767..1443399	Mycobacterium tuberculosis H37Rv	886994
NP_215806.1	CDS	Rv1290c	NC_000962.2	1443482	1445047	R	Rv1290c, (MTCY373.09c), len: 521 aa. Conserved hypothetical protein (see citation below), similar to AL031013|SC8A6.09 hypothetical protein from Streptomyces coelicolor (443 aa), FASTA scores: opt: 371, E(): 9.5e-17, (28.3% identity in 446 aa overlap).; hypothetical protein	complement(1443482..1445047)	Mycobacterium tuberculosis H37Rv	886971
YP_177642.1	CDS	Rv1290A	NC_000962.2	1445058	1445372	D	Rv1290A, len: 104 aa. Hypothetical unknown protein, equivalent to AAK45590 from Mycobacterium tuberculosis strain CDC1551 (122 aa) but shorter 18 aa.; hypothetical protein	1445058..1445372	Mycobacterium tuberculosis H37Rv	3205114
NP_215807.1	CDS	Rv1291c	NC_000962.2	1445499	1445834	R	Rv1291c, (MTCY373.10c), len: 111 aa. Conserved hypothetical secreted protein, similar to others in Mycobacterium tuberculosis e.g. Rv1271c|Q11048|YC71_MYCTU HYPOTHETICAL 11.6 kDa PROTEIN (113 aa), FASTA score: opt: 246, E(): 1.7e-09, (40.0% identity in 110 aa overlap); Rv1804c, Rv1810, Rv0622, etc.; hypothetical protein	complement(1445499..1445834)	Mycobacterium tuberculosis H37Rv	886975
NP_215808.1	CDS	argS	NC_000962.2	1446379	1448031	D	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase	1446379..1448031	Mycobacterium tuberculosis H37Rv	886964
NP_215809.1	CDS	lysA	NC_000962.2	1448028	1449371	D	Rv1293, (MTCY373.13), len: 447 aa. Probable lysA, diaminopimelate decarboxylase (EC 4.1.1.20) (see citation below), almost identical to DCDA_MYCTU|P31848. Contains PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site, PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. BELONGS TO FAMILY 2 OF ORNITHINE, DAP, AND ARGININE DECARBOXYLASES.; diaminopimelate decarboxylase LysA	1448028..1449371	Mycobacterium tuberculosis H37Rv	886960
NP_215810.1	CDS	thrA	NC_000962.2	1449375	1450700	D	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase	1449375..1450700	Mycobacterium tuberculosis H37Rv	886962
NP_215811.1	CDS	thrC	NC_000962.2	1450697	1451779	D	catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase	1450697..1451779	Mycobacterium tuberculosis H37Rv	886957
NP_215812.1	CDS	thrB	NC_000962.2	1451997	1452947	D	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase	1451997..1452947	Mycobacterium tuberculosis H37Rv	886958
NP_215813.1	CDS	rho	NC_000962.2	1453204	1455012	D	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho	1453204..1455012	Mycobacterium tuberculosis H37Rv	886952
NP_215814.1	CDS	rpmE	NC_000962.2	1455163	1455405	D	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31	1455163..1455405	Mycobacterium tuberculosis H37Rv	886955
NP_215815.1	CDS	prfA	NC_000962.2	1455495	1456568	D	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1	1455495..1456568	Mycobacterium tuberculosis H37Rv	886948
NP_215816.1	CDS	hemK	NC_000962.2	1456565	1457542	D	Rv1300, (MTCY373.20), len: 325 aa. Probable hemK protein homolog (EC 2.1.1.-), homology suggests translation may start at aa 22, highly similar to many e.g. HEMK_MYCLE|P45832 Mycobacterium leprae (288 aa), FASTA scores: opt: 936, E(): 0, (76.7% identity in 189 aa overlap). BELONGS TO THE HEMK FAMILY OF MODIFICATION METHYLASES.; hypothetical protein	1456565..1457542	Mycobacterium tuberculosis H37Rv	886950
NP_215817.1	CDS	Rv1301	NC_000962.2	1457558	1458211	D	Rv1301, (MTCY373.21), len: 217 aa. Conserved hypothetical protein, highly similar to YRFE_MYCLE|P45831 hypothetical 22.7 kDa protein in rfe-hemk intergenic region, (220 aa), FASTA scores: opt: 1168, E(): 0, (82.8% identity in 215 aa overlap). Contains PS01147 Hypothetical SUA5/yciO/yrdC family signature. BELONGS TO THE SUA5/YRDC/YCIO/YWLC FAMILY.; hypothetical protein	1457558..1458211	Mycobacterium tuberculosis H37Rv	886970
NP_215818.1	CDS	rfe	NC_000962.2	1458295	1459509	D	Rv1302, (MTCY373.22), len: 404 aa. Probable rfe (alternate gene name: wecA), undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase (EC 2.4.1.-) (see citation below), equivalent to RFE_MYCLE|P45830 Mycobacterium leprae (398 aa), FASTA scores, opt: 2285, E(): 0, (89.2% identity in 398 aa overlap).; wecA; undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase rfe (UDP-GlcNAc transferase)	1458295..1459509	Mycobacterium tuberculosis H37Rv	886947
NP_215819.1	CDS	Rv1303	NC_000962.2	1459766	1460251	D	Rv1303, (MTCY373.23), len: 161 aa. Conserved hypothetical transmembrane protein, highly similar to P53431|Y02N_MYCLE hypothetical Mycobacterium leprae protein (153 aa), FASTA score: opt: 636, E():0, (69.8% identity in 149 aa overlap).; hypothetical protein	1459766..1460251	Mycobacterium tuberculosis H37Rv	886944
NP_215820.1	CDS	atpB	NC_000962.2	1460244	1460996	D	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A	1460244..1460996	Mycobacterium tuberculosis H37Rv	886941
NP_215821.1	CDS	atpE	NC_000962.2	1461045	1461290	D	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C	1461045..1461290	Mycobacterium tuberculosis H37Rv	886937
NP_215822.1	CDS	atpF	NC_000962.2	1461321	1461836	D	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B	1461321..1461836	Mycobacterium tuberculosis H37Rv	886939
NP_215823.1	CDS	atpH	NC_000962.2	1461843	1463183	D	produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta	1461843..1463183	Mycobacterium tuberculosis H37Rv	886934
NP_215824.1	CDS	atpA	NC_000962.2	1463228	1464877	D	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha	1463228..1464877	Mycobacterium tuberculosis H37Rv	886936
NP_215825.1	CDS	atpG	NC_000962.2	1464884	1465801	D	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma	1464884..1465801	Mycobacterium tuberculosis H37Rv	886929
NP_215826.1	CDS	atpD	NC_000962.2	1465841	1467301	D	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta	1465841..1467301	Mycobacterium tuberculosis H37Rv	886932
NP_215827.1	CDS	atpC	NC_000962.2	1467315	1467680	D	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon	1467315..1467680	Mycobacterium tuberculosis H37Rv	886967
NP_215828.1	CDS	Rv1312	NC_000962.2	1467688	1468131	D	Rv1312, (MTCY373.32), len: 147 aa. Conserved hypothetical secreted protein with potential N-terminal signal sequence. Highly similar to P53432|Y02W_MYCLE hypothetical Mycobacterium leprae protein (147 aa), FASTA score: opt: 884, E(): 0, (88.4% identity in 147 aa overlap). N-terminus hydrophobic.; hypothetical protein	1467688..1468131	Mycobacterium tuberculosis H37Rv	886930
NP_215829.1	CDS	Rv1313c	NC_000962.2	1468171	1469505	R	Rv1313c, (MTCY373.33c), len: 444 aa. Possible IS1557 transposase, similar to several transposases e.g. U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3% identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase for insertion sequence element IS1001 from Bordetella parapertussis (406 aa), FASTA scores: opt: 254, E(): 3.3e-10, (24.9% identity in 402 aa overlap). Also similar to putative Mycobacterium tuberculosis transposases, Rv3798 and Rv0741.; transposase	complement(1468171..1469505)	Mycobacterium tuberculosis H37Rv	886922
NP_215830.1	CDS	Rv1314c	NC_000962.2	1469671	1470252	R	Rv1314c, (MTCY373.34c), len: 193 aa. Conserved hypothetical protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap).; hypothetical protein	complement(1469671..1470252)	Mycobacterium tuberculosis H37Rv	886925
NP_215831.1	CDS	murA	NC_000962.2	1470321	1471577	D	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase	1470321..1471577	Mycobacterium tuberculosis H37Rv	886921
NP_215832.1	CDS	ogt	NC_000962.2	1477134	1477631	R	Rv1316c, (MTCY130.01c), len: 165 aa. Probable ogt, methylated-dna--protein-cysteine methytransferase (EC 2.1.1.63) (see citation below), similar to many e.g. OGT_HAEIN|P44687 Haemophilus influenzae (190 aa), FASTA scores: opt: 405, E(): 6.5e-20, (41.9% identity in 155 aa overlap). Contains PS00374 Methylated-DNA--protein-cysteine methyltransferase active site.; methylated-DNA--protein-cysteine methyltransferase	complement(1477134..1477631)	Mycobacterium tuberculosis H37Rv	886913
NP_215833.1	CDS	alkA	NC_000962.2	1477628	1479118	R	Rv1317c, (MTCY130.02c), len: 496 aa. Probable alkA (alternate gene name: ada), regulatory protein (EC 2.1.1.63) (see citation below), similar to 3MG2_ECOLI|P04395 dna-3-methyladenine glycosidase II from Escherichia coli (282 aa), FASTA scores, opt: 437, E(): 8.6e-22, (32.8% identity in 293 aa overlap), also similar to other ada proteins e.g. ADA_SALTY|P26189 Salmonella typhimurium (352 aa), FASTA scores: E(): 5.3e-08, (35.9% identity in 156 aa overlap). Contains PS00041 Bacterial regulatory proteins, araC family signature.; ada; bifunctional methylated-DNA--protein-cysteine methyltransferase/O-6-methylguanine-DNA transcription regulator	complement(1477628..1479118)	Mycobacterium tuberculosis H37Rv	886916
NP_215834.1	CDS	Rv1318c	NC_000962.2	1479199	1480824	R	Rv1318c, (MTCY130.03c), len: 541 aa. Possible adenylate cyclase (EC 4.6.1.1). Some similarity at the c-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores, opt: 270, E(): 2.5e-11, (28.8% identity in 184 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505, E(): 0, (71.0% identity in 534 aa overlap), also similar to Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423, E(): 0, (68.7% identity in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY.; adenylate cyclase	complement(1479199..1480824)	Mycobacterium tuberculosis H37Rv	886910
NP_215835.1	CDS	Rv1319c	NC_000962.2	1480894	1482501	R	Rv1319c, (MTCY130.04c), len: 535 aa. Possible adenylate cyclase (EC 4.6.1.1). Some similarity at the C-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores: opt: 254, E(): 2.4e-10, (33.3% identity in 144 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2505, E(): 0, (71.0% identity in 534 aa overlap); Rv1320c|MTCY130.05c (567 aa), FASTA scores: opt: 2354, E(): 0, (66.3% identity in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY.; adenylate cyclase	complement(1480894..1482501)	Mycobacterium tuberculosis H37Rv	886911
NP_215836.1	CDS	Rv1320c	NC_000962.2	1482514	1484217	R	Rv1320c, (MTCY130.05c), len: 567 aa. Possible adenylate cyclase (EC 4.6.1.1) (see Rindi et al., 1999). Some similarity at the C-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores: opt: 277, E(): 2e-12, (34.0% identity in 156 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2423, E(): 0, (68.7% identity in 534 aa overlap); Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2354, E(): 0, (66.3% identity in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY.; adenylate cyclase	complement(1482514..1484217)	Mycobacterium tuberculosis H37Rv	886906
NP_215837.1	CDS	Rv1321	NC_000962.2	1484279	1484959	D	Rv1321, (MTCY130.06), len: 226 aa. Conserved hypothetical protein. Equivalent to P53524|YD21_MYCLE hypothetical protein from Mycobacterium leprae (201 aa), FASTA scores: opt: 1144, E(): 0, (87.6% identity in 193 aa overlap). Some similarity to hypothetical proteins from other organisms e.g. Y225_METJA|Q57678 Methanococcus jannaschii (263 aa), FASTA scores: E(): 6.5e-05, (25.0% identity in 212 aa overlap).; hypothetical protein	1484279..1484959	Mycobacterium tuberculosis H37Rv	886908
NP_215838.1	CDS	Rv1322	NC_000962.2	1484982	1485278	D	Rv1322, (MTCY130.07), len: 98 aa. Conserved hypothetical protein.; hypothetical protein	1484982..1485278	Mycobacterium tuberculosis H37Rv	886927
YP_177643.1	CDS	Rv1322A	NC_000962.2	1485313	1485771	R	Rv1322A, len: 152 aa. Conserved hypothetical protein, similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. AL583921_2|ML1157 from M. leprae strain TN (155 aa), FASTA scores: opt: 771, E(): 5.1e-43, (75.3% identity in 154 aa overlap); and AL137242_2 from Streptomyces coelicolor (146 aa), FASTA scores: opt: 404, E(): 2e-19, (43.165% identity in 139 aa overlap).; hypothetical protein	complement(1485313..1485771)	Mycobacterium tuberculosis H37Rv	3205097
NP_215839.1	CDS	fadA4	NC_000962.2	1485862	1487031	D	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase	1485862..1487031	Mycobacterium tuberculosis H37Rv	886904
NP_215840.1	CDS	Rv1324	NC_000962.2	1487161	1488075	D	Rv1324, (MTCY130.09), len: 304 aa. Possible thioredoxin (EC 1.-.-.-), similar to several e.g. U00014|Q49716 TRXA from Mycobacterium leprae (255 aa), FASTA scores: opt: 1014, E(): 0, (69.7% identity in 228 aa overlap); THIO_RHOSH|P08058 TrxA from Rhodobacter sphaeroides (105 aa), FASTA scores: opt 196, E(): 1.9e-06, (33.0% identity in 103 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.; thioredoxin	1487161..1488075	Mycobacterium tuberculosis H37Rv	886897
YP_177799.1	CDS	PE_PGRS24	NC_000962.2	1488154	1489965	R	Rv1325c, (MTCY130.10c), len: 603 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of ala-, gly-rich proteins (see Brennan & Delogu 2002), similar to many e.g. YQ04_MYCTU|P71933 hypothetical 63.1 kDa glycine-rich protein (778 aa), FASTA scores: E(): 0, (52.3% identity in 724 aa overlap).; PE-PGRS family protein	complement(1488154..1489965)	Mycobacterium tuberculosis H37Rv	886899
NP_215842.1	CDS	glgB	NC_000962.2	1490117	1492312	R	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme	complement(1490117..1492312)	Mycobacterium tuberculosis H37Rv	886893
NP_215843.2	CDS	glgE	NC_000962.2	1492320	1494425	R	Rv1327c, (MTCY130.12c), len: 701 aa. Probable glgE, glucanase, similar to AF172946|AF172946_2 putative glucanase GlgE from Mycobacterium smegmatis (697 aa), FASTA scores: opt: 3816, E(): 0, (78.5% identity in 692 aa overlap). Similar to putative alpha-amylases e.g. Q9L1K2 Streptomyces coelicolor (675 aa), FASTA scores: opt: 2243, E(): 7.4e-132, (54.2% identity in 684 aa overlap). Start changed since original submission (-36) based on similarity to GlgE of Mycobacterium smegmatis; previous start at position 1494531.; glucanase GLGE	complement(1492320..1494425)	Mycobacterium tuberculosis H37Rv	886895
NP_215844.1	CDS	glgP	NC_000962.2	1494564	1497155	D	Rv1328, (MTCY130.13), len: 863 aa. Probable glgP, glycogen phosphorylase (EC 2.4.1.1), similar to many e.g. PHSG_HAEIN|P45180 glycogen phosphorylase from Haemophilus influenzae (821 aa), FASTA scores: E(): 6.9e-08, (25.6% identity in 675 aa overlap). BELONGS TO THE GLYCOGEN PHOSPHORYLASE FAMILY.; glycogen phosphorylase GlgP	1494564..1497155	Mycobacterium tuberculosis H37Rv	886886
NP_215845.1	CDS	dinG	NC_000962.2	1497195	1499189	R	Rv1329c, (MTCY130.14c), len: 664 aa. Probable dinG, ATP-dependent helicase (see citation below), similar to several e.g. DING_HAEIN|P44680 probable ATP-dependent helicase ding from Haemophilus influenzae (640 aa), FASTA scores: opt: 685, E(): 2.3e-38, (32.8% identity in 644 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.; ATP-dependent helicase DING	complement(1497195..1499189)	Mycobacterium tuberculosis H37Rv	886889
NP_215846.2	CDS	Rv1330c	NC_000962.2	1499213	1500559	R	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase	complement(1499213..1500559)	Mycobacterium tuberculosis H37Rv	886884
NP_215847.1	CDS	clpS	NC_000962.2	1500661	1500966	D	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS	1500661..1500966	Mycobacterium tuberculosis H37Rv	886891
NP_215848.1	CDS	Rv1332	NC_000962.2	1500926	1501582	D	Rv1332, (MTCY130.17), len: 218 aa. Possible regulatory protein, high similarity to ML014|U00014 M. leprae B1549_C3_236 (222 aa), FASTA scores: opt: 1158, E(): 0, (75.6% identity in 221 aa overlap). Helix turn helix motif fram aa 8-29 (+3.03 SD).; transcriptional regulatory protein	1500926..1501582	Mycobacterium tuberculosis H37Rv	886901
NP_215849.1	CDS	Rv1333	NC_000962.2	1501599	1502633	D	Rv1333, (MTCY130.18), len: 344 aa. Possible hydrolase (EC 3.-.-.-), similar to Q57326|D26094 endo-type 6-aminohexanoate oligomer hydrolase (355 aa), fasta scores: E(): 1.4e-10, (31.9% identity in 339 aa overlap). Equivalent to P53425|YD33_MYCLE HYPOTHETICAL 36.1 KD PROTEIN B154 Mycobacterium leprae (362 aa), FASTA scores: opt: 1735, E(): 0, (76.7% identity in 352 aa overlap).; hydrolase	1501599..1502633	Mycobacterium tuberculosis H37Rv	886882
NP_215850.1	CDS	Rv1334	NC_000962.2	1502641	1503081	D	Rv1334, (MTCY130.19), len: 146 aa. Conserved hypothetical protein, similar to AL096852|SCE19A_13 hypothetical protein from Streptomyces coelicolor (140 aa), Fasta scores: opt: 579, E(): 0, (65.0% identity in 140 aa overlap); and Q54330|M29166 MEC+ from Streptomyces kasugaensis (115 aa), FASTA scores; E(): 7.6e-33, (56.9% identity in 109 aa overlap).; hypothetical protein	1502641..1503081	Mycobacterium tuberculosis H37Rv	886875
NP_215851.1	CDS	Rv1335	NC_000962.2	1503103	1503384	D	Rv1335, (MT1376.1, MTCY130.20), len: 93 aa. 9.5 kDa culture filtrate antigen cfp10A (see citation below). Similar to hypothetical proteins from other organisms e.g. P74060|D90911 Synechocystis (109 aa), FASTA scores: E(): 2.3e-20, (49.5% identity in 93 aa overlap).; 9.5 kDa culture filtrate antigen CFP10A	1503103..1503384	Mycobacterium tuberculosis H37Rv	886879
NP_215852.1	CDS	cysM	NC_000962.2	1503394	1504365	D	Rv1336, (MTCY130.21), len: 323 aa. Probable cysM, cysteine synthase B (EC 4.2.99.8), similar to many e.g. CYSM_ECOLI|P16703 Escherichia coli (303 aa), FASTA scores: opt: 720, E(): 4.6e-40, (41.1% identity in 302 aa overlap). Also similar to other Mycobacterium tuberculosis cysteine synthase subunits e.g. Rv1077, Rv2334, Rv0848, etc. Contains PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY.; cysteine synthase B CysM	1503394..1504365	Mycobacterium tuberculosis H37Rv	886867
NP_215853.1	CDS	Rv1337	NC_000962.2	1504356	1505078	D	Rv1337, (MTCY130.22), len: 240 aa. Probable integral membrane protein. Highly similar to P53426 hypothetical protein B1549_C3_240 from M.leprae (251); and P74553|D90916 hypothetical protein from Synechocystis sp. (198 aa), FASTA scores: E(): 2.3e-25, (43.6% identity in 181 aa overlap).; integral membrane protein	1504356..1505078	Mycobacterium tuberculosis H37Rv	886870
NP_215854.1	CDS	murI	NC_000962.2	1505075	1505890	D	converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase	1505075..1505890	Mycobacterium tuberculosis H37Rv	886866
NP_215855.1	CDS	Rv1339	NC_000962.2	1505917	1506738	D	Rv1339, (MTCY130.24), len: 273 aa. Conserved hypothetical protein, highly similar to Y211_MYCLE|P50474 hypothetical protein b1549_c2_211 from Mycobacterium leprae (284 aa), FASTA scores: opt: 1672, E(): 0, (86.2% identity in 276 aa overlap). Also similar to AL096852|SCE19A.08 hypothetical protein from Streptomyces coelicolor (250 aa), FASTA scores: opt: 630, E(): 0, (42.2% identity in 256 aa overlap). Similar to M. tuberculosis hypothetical proteins Rv3796, Rv2407.; hypothetical protein	1505917..1506738	Mycobacterium tuberculosis H37Rv	886972
NP_215856.1	CDS	rph	NC_000962.2	1506755	1507534	D	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH	1506755..1507534	Mycobacterium tuberculosis H37Rv	886864
NP_215857.1	CDS	Rv1341	NC_000962.2	1507573	1508187	D	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase	1507573..1508187	Mycobacterium tuberculosis H37Rv	886861
YP_177800.1	CDS	Rv1342c	NC_000962.2	1508184	1508546	R	Rv1342c, (MTCY02B10.06c), len: 120 aa. Conserved membrane protein. Highly similar to G466926|P54133 hypothetical protein B1549_F2_59 from Mycobacterium leprae (119 aa), FASTA scores, opt: 544, E(): 1.9e-29, (68.3 % identity in 120 aa overlap).; hypothetical protein	complement(1508184..1508546)	Mycobacterium tuberculosis H37Rv	886862
NP_215859.1	CDS	lprD	NC_000962.2	1508543	1508923	R	Rv1343c, (MTCY02B10.07c), len: 126 aa. Probable lprD, conserved lipoprotein, highly similar to G466928 Mycobacterium leprae protein B1549_F3_106 (126 aa), FASTA scores, opt: 704, E(): 7.5e-36, (78.4 % identity in 125 aa overlap). Has N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LprD	complement(1508543..1508923)	Mycobacterium tuberculosis H37Rv	886852
NP_215860.1	CDS	Rv1344	NC_000962.2	1508968	1509288	D	carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein	1508968..1509288	Mycobacterium tuberculosis H37Rv	886848
NP_215861.1	CDS	fadD33	NC_000962.2	1509281	1510846	D	converts medium- to long-chain aliphatic fatty acids into acyl adenylate; involved in mycobactin synthesis; long-chain-fatty-acid--[acyl-carrier-protein] ligase	1509281..1510846	Mycobacterium tuberculosis H37Rv	886855
NP_215862.1	CDS	fadE14	NC_000962.2	1510846	1512006	D	Rv1346, (MTCY02B10.10), len: 386 aa. Possible fadE14, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. NP_251579.1|NC_002516 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (386 aa); NP_036951.1|NM_012819|ACDL_RAT|P15650 acyl Coenzyme A dehydrogenase (long chain) from Rattus norvegicus (430 aa), FASTA scores: opt: 414, E(): 1.2e-18, (26.1% identity in 376 aa overlap); etc.; acyl-CoA dehydrogenase	1510846..1512006	Mycobacterium tuberculosis H37Rv	886844
NP_215863.1	CDS	Rv1347c	NC_000962.2	1511973	1512605	R	Rv1347c, (MTCY02B10.11c), len: 210 aa. Conserved hypothetical protein, some similarity to the C-terminus of malonyl-coenzyme A carboxylases e.g. G545170 malonyl-coenzyme A carboxylase (417 aa), FASTA scores: opt: 392, E(): 4.9 e-20, (35.6% identity in 174 aa overlap).; hypothetical protein	complement(1511973..1512605)	Mycobacterium tuberculosis H37Rv	886846
NP_215864.1	CDS	Rv1348	NC_000962.2	1513047	1515626	D	Rv1348, (MTCY02B10.12), len: 859 aa. Probable drugs-transport transmembrane protein ATP binding protein ABC transporter (see citation below), similar to HMT1_SCHPO|Q02592 heavy metal tolerance protein precursor from Schizosaccharomyces pombe (830 aa), FASTA scores: opt: 806, E(): 5.1e-39, (32.9% identity in 504 aa overlap); etc. Also similar to MTCY02B10.13 from Mycobacterium tuberculosis, FASTA score: (31.9% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; drugs-transport transmembrane ATP-binding protein ABC transporter	1513047..1515626	Mycobacterium tuberculosis H37Rv	886853
NP_215865.1	CDS	Rv1349	NC_000962.2	1515623	1517362	D	Rv1349, (MTCY02B10.13), len: 579 aa. Probable drugs-transport transmembrane ATP binding protein ABC transporter (see citation below), most similar to YWJA_BACSU|P45861 hypothetical ABC transporter from Bacillus subtilis (575 aa), FASTA scores: opt: 721, E(): 1.8e-35, (28.9% identity in 567 aa overlap); etc. Also similar to MTCY02B10.12 from Mycobacterium tuberculosis, FASTA score: (31.9% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; drugs-transport transmembrane ATP-binding protein ABC transporter	1515623..1517362	Mycobacterium tuberculosis H37Rv	886834
NP_215866.1	CDS	fabG	NC_000962.2	1517491	1518234	D	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase	1517491..1518234	Mycobacterium tuberculosis H37Rv	886837
NP_215867.1	CDS	Rv1351	NC_000962.2	1518231	1518560	D	Rv1351, (MTCY02B10.15), len: 109 aa. Hypothetical unknown protein.; hypothetical protein	1518231..1518560	Mycobacterium tuberculosis H37Rv	886831
NP_215868.1	CDS	Rv1352	NC_000962.2	1518763	1519134	D	Rv1352, (MTCY02B10.16), len: 123 aa. Conserved hypothetical protein, some similarity to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: E(): 4e-05, (36.2% identity in 116 aa overlap).; hypothetical protein	1518763..1519134	Mycobacterium tuberculosis H37Rv	886833
NP_215869.1	CDS	Rv1353c	NC_000962.2	1519200	1519985	R	Rv1353c, (MTCY02B10.17c), len: 261 aa. Probable transcriptional regulatory protein, similar to TER1_ECOLI|P03038 tetracycline repressor protein class A from Escherichia coli (216 aa), FASTA scores, opt: 231, E(): 1.6e-08, (31.3% identity in 211 aa overlap). Helix turn helix motif present at aa 3859 (+3.59 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.; transcriptional regulatory protein	complement(1519200..1519985)	Mycobacterium tuberculosis H37Rv	886827
NP_215870.1	CDS	Rv1354c	NC_000962.2	1520005	1521876	R	Rv1354c, (MTCY02B10.18c), len: 623 aa. Conserved hypothetical protein, similar to many hypothetical proteins e.g. the C-terminus of G1001455 Synechocystis sp. (1244 aa), FASTA scores: opt: 933, E(): 0, (36.8% identity in 462 aa overlap); also similar to Rv1357c|MTCY02B10.21c (34.0% identity in 253 aa overlap).; hypothetical protein	complement(1520005..1521876)	Mycobacterium tuberculosis H37Rv	886829
NP_215871.1	CDS	moeY	NC_000962.2	1521885	1524032	R	Rv1355c, (MTCY02B10.19c), len: 715 aa. Possible moeY, Molybdopterin biosynthesis protein, very weak similarity to MOEB_ECOLI|P12282 molybdopterin biosynthesis moeb protein (249 aa), FASTA scores, opt: 180, E(): 8.5e-05, (29.3% identity in 174 aa overlap).; hypothetical protein	complement(1521885..1524032)	Mycobacterium tuberculosis H37Rv	886839
NP_215872.1	CDS	Rv1356c	NC_000962.2	1524029	1524820	R	Rv1356c, (MTCY02B10.20c), len: 263 aa. Hypothetical unknown protein.; hypothetical protein	complement(1524029..1524820)	Mycobacterium tuberculosis H37Rv	886850
NP_215873.1	CDS	Rv1357c	NC_000962.2	1525293	1526216	R	Rv1357c, (MTCY02B10.21c), len: 307 aa. Conserved hypothetical protein, similar to members of the YEGE/YHJK/YJCC family e.g. Y4LL_RHISN|P55552 hypothetical protein Y4ll from Rhizobium sp. (827 aa), FASTA scores: E(): 0, (37.7% identity in 257 aa overlap), also similar to Rv1354c|MTCY02B10.18c (34.0% identity in 253 aa overlap). BELONGS TO THE YEGE/YHDA/YHJK/YJCC FAMILY.; hypothetical protein	complement(1525293..1526216)	Mycobacterium tuberculosis H37Rv	886815
NP_215874.1	CDS	Rv1358	NC_000962.2	1526612	1530091	D	Rv1358, (MTCY02B10.22), len: 1159 aa. Probable transcriptional regulatory protein, some similarity to AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces coelicolor (993 aa), FASTA scores: opt: 210, E(): 5.5e-06, (27.5% identity in 739 aa overlap). Similar also to Rv0890C|MTCY31.18c (65.5% identity in 884 aa overlap) and to Rv1359|MTCY02B10.23 (43.7% identity in 197 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, PS00622 Bacterial regulatory proteins, luxR family signature. Helix turn helix motif present at aa 1116-1137, (Score 1291, +3.59 SD).; transcriptional regulatory protein	1526612..1530091	Mycobacterium tuberculosis H37Rv	886817
NP_215875.1	CDS	Rv1359	NC_000962.2	1530173	1530925	D	Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap).; transcriptional regulatory protein	1530173..1530925	Mycobacterium tuberculosis H37Rv	886841
NP_215876.1	CDS	Rv1360	NC_000962.2	1531348	1532370	D	Rv1360, (MTCY02B10.24), len: 340 aa. Probable oxidoreductase (EC 1.-.-.-). Similar to Q49598|G1002714 coenzyme F420-dependent n5, n10-methylenetetrahydromethanopterin reductase from Methanopyrus kandleri (349 aa), FASTA scores: opt: 264, E(): 4.4e-11, (26.3% identity in 323 aa overlap).; oxidoreductase	1531348..1532370	Mycobacterium tuberculosis H37Rv	886813
YP_177801.1	CDS	PPE19	NC_000962.2	1532443	1533633	R	Rv1361c, (MTCY02B10.25c), len: 396 aa. PPE19 (alternate gene name: mtb39b). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to many e.g. Rv1196|MTCI364.08|PPE18, FASTA scores: E(): 0, (84.9% identity in 397 aa overlap); MTCY274.23c (42.3% identity in 416 aa overlap); etc. Contains PS00501 Signal peptidases I serine active site. Note that expression of Rv1361c was demonstrated in lysates by immunodetection (see Dillon et al., 1999).; mtb39b; PPE family protein	complement(1532443..1533633)	Mycobacterium tuberculosis H37Rv	886819
NP_215878.1	CDS	Rv1362c	NC_000962.2	1533948	1534610	R	Rv1362c, (MTCY02B10.26c), len: 220 aa. Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9% identity in 216 aa overlap), Rv0177, Rv1973, Rv1972, etc.; hypothetical protein	complement(1533948..1534610)	Mycobacterium tuberculosis H37Rv	886809
NP_215879.1	CDS	Rv1363c	NC_000962.2	1534607	1535392	R	Rv1363c, (MTCY02B10.27c), len: 261 aa. Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv1362c|MTCY02B10.26c (25.9% identity in 216 aa overlap ); Rv1972|MTV051.10 and Rv0177 etc.; hypothetical protein	complement(1534607..1535392)	Mycobacterium tuberculosis H37Rv	886811
YP_177802.1	CDS	Rv1364c	NC_000962.2	1535683	1537644	R	Rv1364c, (MTCY02B10.28c), len: 653 aa. Conserved hypothetical protein, some similarity to RSBU_BACSU|P40399 sigma factor sibg regulation protein from Bacillus subtilis (335 aa), FASTA scores: opt: 224, E(): 2e-07, (25.8% identity in 244 aa overlap).; hypothetical protein	complement(1535683..1537644)	Mycobacterium tuberculosis H37Rv	886802
NP_215881.1	CDS	rsfA	NC_000962.2	1537783	1538169	R	Rv1365c, (MTCY02B10.29c), len: 128 aa. rsfA, anti-anti-sigma factor (see citation below), similar to other Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08 (148 aa), FASTA scores: E(): 0, (53.6% identity in 125 aa overlap); Rv1904, Rv3687c. Weak similarity to putative anti-anti-sigma factors e.g. AF134889|AF134889_1 Streptomyces coelicolor (113 aa), FASTA scores: opt: 137, E(): 0.004, (26.0% identity in 100 aa overlap).; anti-anti-sigma factor RSFA (anti-sigma factor antagonist) (regulator of sigma F A)	complement(1537783..1538169)	Mycobacterium tuberculosis H37Rv	886794
NP_215882.1	CDS	Rv1366	NC_000962.2	1538390	1539211	D	Rv1366, (MTCY02B10.30), len: 273 aa. Hypothetical unknown protein.; hypothetical protein	1538390..1539211	Mycobacterium tuberculosis H37Rv	886805
NP_215883.1	CDS	Rv1367c	NC_000962.2	1539512	1540645	R	Rv1367c, (MTCY02B12.01c,MTCY02B10.31c), len: 377 aa. Conserved hypothetical protein. Some similarity to penicillin binding proteins e.g. PBPE_BACSU|P32959 penicillin-binding protein 4* (pbp 4*) from Bacillus subtilis (451 aa), FASTA scores: E(): 6.9e-06, (23.6% identity in 373 aa overlap). Similar to AL031107|SC5A7.06 hypothetical protein from Streptomyces coelicolor (409 aa), FASTA scores: opt: 675, E(): 0, (40.4% identity in 339 aa overlap).; hypothetical protein	complement(1539512..1540645)	Mycobacterium tuberculosis H37Rv	886793
NP_215884.1	CDS	lprF	NC_000962.2	1541020	1541805	D	Rv1368, (MTCY02B12.02), len: 261 aa. Probable lprF, conserved lipoprotein; similar to Mycobacterium tuberculosis hypothetical lipoproteins e.g. Rv1270c|Y08C_MYCTU|Q11049 hypothetical 26.4 kDa protein cy50.12. (257 aa), FASTA scores: opt: 286, E(): 5.3e-11, (26.3% identity in 270 aa overlap), also Rv1411c|MTCY21B4.28c, (32.8% identity in 253 aa overlap) and Rv2945c. Contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). BELONGS TO THE LPPX/LPRAFG FAMILY OF LIPOPROTEINS.; lipoprotein LprF	1541020..1541805	Mycobacterium tuberculosis H37Rv	886798
NP_215885.1	CDS	Rv1369c	NC_000962.2	1541994	1542878	R	Rv1369c, (MTCY02B12.03c), len: 294 aa. Probable transposase subunit for IS6110, identical from aa 69 to TRA9_MYCTU|P19774 putative transposase for insertion sequence.; transposase	complement(1541994..1542878)	Mycobacterium tuberculosis H37Rv	886789
NP_215886.1	CDS	Rv1370c	NC_000962.2	1542929	1543255	R	Rv1370c, (MTCY02B12.04c), len: 108 aa. Probable transposase subunit for IS6110, highly similar to G309867 IS401 transposase subunit (107 aa), FASTA scores: opt: 325, E(): 2.7e-1 6, (52.9% identity in 102 aa overlap).; transposase	complement(1542929..1543255)	Mycobacterium tuberculosis H37Rv	886791
NP_215887.1	CDS	Rv1371	NC_000962.2	1543359	1544828	D	Rv1371, (MTCY02B12.05), len: 489 aa. Probable membrane protein. Weak similarity to delta 5 fatty acid desaturases e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052, (22.4% identity in 438 aa overlap); and Homo sapiens.; hypothetical protein	1543359..1544828	Mycobacterium tuberculosis H37Rv	886800
YP_177803.1	CDS	Rv1372	NC_000962.2	1544825	1546006	D	Rv1372, (MTCY02B12.06), len: 393 aa. Conserved hypothetical protein, similar to several chalcone synthases e.g. CHS2_GERHY|P48391 chalcone synthase 2 from gerbra hybrid (402 aa), FASTA scores: opt: 511, E(): 7e-26, (28.4% identity in 380 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical chalcone synthases, Rv1665, Rv1660.; hypothetical protein	1544825..1546006	Mycobacterium tuberculosis H37Rv	886797
NP_215889.1	CDS	Rv1373	NC_000962.2	1546012	1546992	D	Rv1373, (MTCY02B12.07), len: 326 aa. Glycolipid sulfotransferase (EC 2.8.2.-) (see citation below); slight similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 estrogen sulfotransferase from Cavia porcellus (Guinea pig) (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054, (24.5% identity in 294 aa overlap).; glycolipid sulfotransferase	1546012..1546992	Mycobacterium tuberculosis H37Rv	886781
NP_215890.2	CDS	Rv1374c	NC_000962.2	1547072	1547530	R	Rv1374c, (MTCY02B12.08c), len: 152 aa. Hypothetical unknown protein.; hypothetical protein	complement(1547072..1547530)	Mycobacterium tuberculosis H37Rv	886783
NP_215891.1	CDS	Rv1375	NC_000962.2	1547832	1549151	D	Rv1375, (MTCY02B12.09), len: 439 aa. Conserved hypothetical protein, similar to hypothetical proteins from several organisms e.g. Q52871|U39409 Rhizobium leguminosarum (420 aa), FASTA scores: E(): 2e-30, (34.4% identity in 378 aa overlap).; hypothetical protein	1547832..1549151	Mycobacterium tuberculosis H37Rv	886778
NP_215892.1	CDS	Rv1376	NC_000962.2	1549148	1550641	D	Rv1376, (MTCY02B12.10), len: 497 aa. Conserved hypothetical protein, some similarity to hypothetical proteins from several organisms e.g. Q52872|U39409 Rhizobium leguminosarum (247 aa), FASTA scores: E(): 2.1e-12, (34.7% identity in 219 aa overlap).; hypothetical protein	1549148..1550641	Mycobacterium tuberculosis H37Rv	886777
NP_215893.1	CDS	Rv1377c	NC_000962.2	1550579	1551217	R	Rv1377c, (MTCY02B12.11c), len: 212 aa. Putative transferase (EC 2.-.-.-), similar to YQEM_BACSU|P54458 hypothetical 28.3 kDa protein from Bacillus subtilis (247 aa), FASTA scores: opt: 221, E(): 7.6e-08, (30.6% identity in 144 aa overlap); some similarity to methyltransferases, also similar to Mycobacterium tuberculosis hypothetical proteins Rv0560c, Rv3699, and Rv2675c ( 39.1% identity in 197 aa overlap).; putative transferase	complement(1550579..1551217)	Mycobacterium tuberculosis H37Rv	886775
NP_215894.1	CDS	Rv1378c	NC_000962.2	1551228	1552655	R	Rv1378c, (MTCY02B12.12c), len: 475 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv3074|MTCY22D7.07C (424 aa), FASTA scores: E(): 0, (73.0% identity in 429 aa overlap).; hypothetical protein	complement(1551228..1552655)	Mycobacterium tuberculosis H37Rv	886773
NP_215895.1	CDS	pyrR	NC_000962.2	1552654	1553235	D	regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase	1552654..1553235	Mycobacterium tuberculosis H37Rv	886769
NP_215896.1	CDS	pyrB	NC_000962.2	1553232	1554191	D	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit	1553232..1554191	Mycobacterium tuberculosis H37Rv	886771
NP_215897.1	CDS	pyrC	NC_000962.2	1554188	1555480	D	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase	1554188..1555480	Mycobacterium tuberculosis H37Rv	886765
NP_215898.1	CDS	Rv1382	NC_000962.2	1555477	1555974	D	Rv1382, (MTCY02B12.16), len: 165 aa. Possible exported or membrane protein, hydrophobic domain at N-terminus.; export or membrane protein	1555477..1555974	Mycobacterium tuberculosis H37Rv	886767
NP_215899.1	CDS	carA	NC_000962.2	1555971	1557101	D	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit	1555971..1557101	Mycobacterium tuberculosis H37Rv	886761
YP_177804.1	CDS	carB	NC_000962.2	1557101	1560448	D	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit	1557101..1560448	Mycobacterium tuberculosis H37Rv	886253
NP_215901.1	CDS	pyrF	NC_000962.2	1560445	1561269	D	OMP decarboxylase; OMPDCase; OMPdecase; type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase	1560445..1561269	Mycobacterium tuberculosis H37Rv	886763
YP_177805.1	CDS	PE15	NC_000962.2	1561464	1561772	D	Rv1386, (MTCY21B4.03), len: 102 aa. Member of Mycobacterium tuberculosis PE family (see Brennan & Delogu 2002), similar to many e.g. G913039 ORF 3' OF PGRS TANDEM REPEAT (polymorphic GC-rich sequence) (100 aa), FASTA scores: opt: 149, E(): 0.0013, (31.5% identity in 92 aa overlap); also similar to Q49943|U1756A (99 aa) (34.7% identity in 95 aa overlap) and G466937|U1620K (100 aa) (36.2% identity in 69 aa overlap).; PE family protein	1561464..1561772	Mycobacterium tuberculosis H37Rv	886757
YP_177806.1	CDS	PPE20	NC_000962.2	1561769	1563388	D	Rv1387, (MTCY21B4.04), len: 539 aa. Member of Mycobacterium tuberculosis PPE family of proteins, similar to many e.g. Y05F_MYCTU|Q10892 hypothetical 46.9 kd protein cy251.15 (463 aa), FASTA scores: E(): 4.2e-26, (37.7% identity in 531 aa overlap); similar also to MTCY274.23c (37.5% identity in 168 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.; PPE family protein	1561769..1563388	Mycobacterium tuberculosis H37Rv	886784
NP_215904.1	CDS	mihF	NC_000962.2	1563694	1564266	D	Rv1388, (MTCY21B4.05), len: 190 aa. Putative mihF, integration host factor. Almost identical to, but longer than, P96802|U75344 Mycobacterium smegmatis integration host factor (mIHF) for mycobacteriophage L5 (105 aa), FASTA scores: E(): 0, (96.1% identity in 102 aa overlap).; putative integration host factor MIHF	1563694..1564266	Mycobacterium tuberculosis H37Rv	886751
NP_215905.1	CDS	gmk	NC_000962.2	1564401	1565027	D	Essential for recycling GMP and indirectly, cGMP; guanylate kinase	1564401..1565027	Mycobacterium tuberculosis H37Rv	886787
NP_215906.1	CDS	rpoZ	NC_000962.2	1565093	1565425	D	Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega	1565093..1565425	Mycobacterium tuberculosis H37Rv	886754
NP_215907.1	CDS	dfp	NC_000962.2	1565441	1566697	D	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase	1565441..1566697	Mycobacterium tuberculosis H37Rv	886749
NP_215908.1	CDS	metK	NC_000962.2	1566825	1568036	D	methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase	1566825..1568036	Mycobacterium tuberculosis H37Rv	886741
NP_215909.1	CDS	Rv1393c	NC_000962.2	1568109	1569587	R	Rv1393c, (MTCY21B4.10c), len: 492 aa. Probable monooxygenase (EC 1.14.13.-), similar to others e.g. CYMO_ACISP|P12015 cyclohexanone monooxygenase (EC 1.14.13.22) from Acinetobacter sp. (542 aa), FASTA scores: E(): 0, (33.0% identity in 473 aa overlap); also to Rv3083|MTCY31.20|E241788 hypothetical 55.0 kDa protein from Mycobacterium tuberculosis (495 aa) (36.3% identity in 490 aa overlap); and Rv0565c, Rv3854c, Rv3049c, Rv0892.; monoxygenase	complement(1568109..1569587)	Mycobacterium tuberculosis H37Rv	886743
YP_177807.1	CDS	cyp132	NC_000962.2	1569584	1570969	R	Rv1394c, (MT1439, MTCY21B4.11c), len: 461 aa. Probable cyp132, cytochrome P450 132 (EC 1.14.-.-). Some similarity to others e.g. CP4B_HUMAN|P13584 human cytochrome p450 (511 aa), FASTA scores: opt: 486, E(): 7.4e-21, (28.6% identity in 423 aa overlap); etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. MAY BELONG TO THE CYTOCHROME P450 FAMILY.; cytochrome P450 132	complement(1569584..1570969)	Mycobacterium tuberculosis H37Rv	886738
YP_177808.1	CDS	Rv1395	NC_000962.2	1571047	1572081	D	Rv1395, (MTCY21B4.12), len: 344 aa. Probable transcriptional regulatory protein (see citation below), similar to many e.g. URER_PROMI|Q02458 urease operon transcriptional activator from Proteus mirabilis (293 aa), FASTA scores: E():1.5e-08, (41.7% identity in 84 aa overlap); YHIX_ECOLI|P37639 hypothetical transcriptional regulatory protein from Escherichia coli (274 aa), FASTA scores: opt: 238, E(): 3.5e-09, (27.3% identity in 249 aa overlap); and G296916|X68281 POSSIBLE VIRULENCE-REGULATING protein from Mycobacterium tuberculosis (339 aa), FASTA scores: opt: 228, E(): 1.9e-08, (27.0% identity in 278 aa overlap). Helix turn helix motif present, aa 261-282 (+4.68 SD). BELONGS TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. 3' part corrected since first submission (-14 aa).; transcriptional regulatory protein	1571047..1572081	Mycobacterium tuberculosis H37Rv	886251
YP_177809.1	CDS	PE_PGRS25	NC_000962.2	1572127	1573857	R	Rv1396c, (MTCY21B4.13c), len: 576 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002), strong similarity to many e.g. glycine rich protein MTCY130.10C|E245019 (603 aa), FASTA scores: opt: 1945, E(): 0, (57.5% identity in 619 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, similar to other PGRS-type sequences.; PE-PGRS family protein	complement(1572127..1573857)	Mycobacterium tuberculosis H37Rv	886745
NP_215913.1	CDS	Rv1397c	NC_000962.2	1574112	1574513	R	Rv1397c, (MTCY21B4.14c), len: 133 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis protein MTCY159.08C|Rv2548 (125 aa), FASTA scores: E(): 2.3e-14, (42.4% identity in 125 aa overlap).; hypothetical protein	complement(1574112..1574513)	Mycobacterium tuberculosis H37Rv	886736
NP_215914.1	CDS	Rv1398c	NC_000962.2	1574510	1574767	R	Rv1398c, (MTCY21B4.15c), len: 85 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis proteins Rv2547|MTCY159.09C (85 aa), FASTA scores: E(): 0.0035, (37.1% identity in 62 aa overlap); Rv0581, Rv2871, Rv1241, etc.; hypothetical protein	complement(1574510..1574767)	Mycobacterium tuberculosis H37Rv	886759
NP_215915.1	CDS	lipH	NC_000962.2	1574850	1575809	R	Rv1399c, (MTCY21B4.16c), len: 319 aa. Possible LipH, lipase (EC 3.1.-.-), most similar to G695278 lipase like enzyme from Ralstonia eutropha (364 aa), FASTA scores: opt: 648, E(): 4.4e-34, (37.3% identity in 327 aa ov erlap), similar to Mycobacterium tuberculosis hypothetical lipases e.g. Rv2284, Rv2485c, Rv1426c, etc.; lipase LipH	complement(1574850..1575809)	Mycobacterium tuberculosis H37Rv	886731
NP_215916.1	CDS	lipI	NC_000962.2	1575834	1576796	R	Rv1400c, (MTCY21B4.17c), len: 320 aa. Possible lipI, lipase (EC 3.1.-.-), most similar to G695278 lipase like enzyme (364 aa), FASTA sscores: opt: 611, E(): 3.5e-30, (36.6% identity in 352 aa overlap); similar to M. tuberculosis hypothetical lipases e.g. Rv1399c|MTCY21B4.16c (58.1% identical in 315 aa overlap); Rv1426c, Rv2284, etc.; lipase LipH	complement(1575834..1576796)	Mycobacterium tuberculosis H37Rv	886728
NP_215917.1	CDS	Rv1401	NC_000962.2	1576930	1577532	D	Rv1401, (MTCY21B4.18), len: 200 aa. Possible membrane protein.; hypothetical protein	1576930..1577532	Mycobacterium tuberculosis H37Rv	886733
NP_215918.1	CDS	priA	NC_000962.2	1577613	1579580	D	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA	1577613..1579580	Mycobacterium tuberculosis H37Rv	886716
NP_215919.1	CDS	Rv1403c	NC_000962.2	1579598	1580422	R	Rv1403c, (MTCY21B4.20c), len: 274 aa. Putative methyltransferase (EC 2.1.1.-), similar to PMTA_RHOSH|Q05197 phosphatidylethanolamine m-methyltransferase (203 aa), FASTA scores: opt: 217, E(): 1.1e-07, (37.1% identity in 105 aa overlap); similar to Rv1405c|MTCY21B4.22c (59.3% identity in 273 aa overlap) and to Rv1523, Rv2952, etc.; putative methyltransferase	complement(1579598..1580422)	Mycobacterium tuberculosis H37Rv	886717
NP_215920.1	CDS	Rv1404	NC_000962.2	1580591	1581073	D	Rv1404, (MTCY21B4.21), len: 160 aa. Probable transcriptional regulatory protein, some similarity to MARR_ECOLI|P27245 multiple antibiotic resistance protein from Escherichia coli (125 aa), FASTA scores: opt: 136, E(): 0.004, (35.1% identity in 74 aa overlap).; transcriptional regulatory protein	1580591..1581073	Mycobacterium tuberculosis H37Rv	886712
NP_215921.1	CDS	Rv1405c	NC_000962.2	1581145	1581969	R	Rv1405c, (MTCY21B4.22c), len: 274 aa. Putative methyltransferase (EC 2.1.1.-), most similar to PMTA_RHOSH|Q05197 phosphatidylethanolamine m-methyltransferase (203 aa), FASTA scores: opt: 219, E(): 2.6e-07, (29.9% identity in 144 aa overlap); similar to Rv1403c|MTCY21B4.20c (59.3% identity in 273 aa overlap), Rv1523, Rv2952, etc.; putative methyltransferase	complement(1581145..1581969)	Mycobacterium tuberculosis H37Rv	886714
NP_215922.1	CDS	fmt	NC_000962.2	1582166	1583104	D	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase	1582166..1583104	Mycobacterium tuberculosis H37Rv	886706
NP_215923.1	CDS	fmu	NC_000962.2	1583101	1584474	D	Rv1407, (MTCY21B4.24), len: 457 aa. Probable fmu protein, similar to SUN_ECOLI|P36929 sun protein (fmu protein) from Escherichia coli (429 aa), FASTA scores: E(): 2.5e-20, (30.6% identity in 451 aa overlap).; Fmu protein (SUN protein)	1583101..1584474	Mycobacterium tuberculosis H37Rv	886720
NP_215924.1	CDS	rpe	NC_000962.2	1584499	1585197	D	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase	1584499..1585197	Mycobacterium tuberculosis H37Rv	886702
NP_215925.1	CDS	ribG	NC_000962.2	1585194	1586213	D	Rv1409, (MTCY21B4.26), len: 339 aa. Probable ribG (alternate gene name: ribD), bifunctional riboflavin biosynthesis protein, including diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193), similar to many e.g. RIBD_ECOLI|P25539 riboflavin-specific deaminase from Escherichia coli (367 aa), FASTA scores: E(): 0, (39.8% identity in 364 aa overlap); etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. IN THE N-TERMINAL SECTION; BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE HTP REDUCTASE FAMILY.; ribD; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino) uracil reductase	1585194..1586213	Mycobacterium tuberculosis H37Rv	886721
NP_215926.1	CDS	Rv1410c	NC_000962.2	1586210	1587766	R	Rv1410c, (MTCY21B4.27c), len: 518 aa. Aminoglycoside/tetracycline-transport integral membrane protein (see citation below), member of major facilitator superfamily (MFS), similar to others e.g. AC22_STRCO|P46105 probable actinorhodin transporter from Streptomyces coelicolor (578 aa), FASTA scores: opt: 442, E(): 4.9e-21, (28.5% identity in 466 aa overlap); etc. Contains PS00216 Sugar transport proteins signature 1. Could be termed P55. Note that the Rv1410c-Rv1411c operon seems transcribed from two promoters in Mycobacterium bovis BCG (see Bigi et al., 2000).; P55; aminoglycosides/tetracycline-transport integral membrane protein	complement(1586210..1587766)	Mycobacterium tuberculosis H37Rv	886709
NP_215927.1	CDS	lprG	NC_000962.2	1587772	1588482	R	Rv1411c, (MTCY21B4.28c), len: 236. Probable lprG (alternate gene name: P27), conserved lipoprotein, similar to Mycobacterium tuberculosis hypothetical lipoproteins e.g. Rv1270c|MTCY50.12 (35.1% identity in 245 aa overlap); Rv1368, Rv2945c. Contains N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Note that the Rv1410c-Rv1411c operon seems transcribed from two promoters in Mycobacterium bovis BCG (see Bigi et al., 2000).; P27; lipoprotein LprG	complement(1587772..1588482)	Mycobacterium tuberculosis H37Rv	886700
NP_215928.1	CDS	ribC	NC_000962.2	1588567	1589172	D	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha	1588567..1589172	Mycobacterium tuberculosis H37Rv	886690
NP_215929.1	CDS	Rv1413	NC_000962.2	1589386	1589901	D	Rv1413, (MTCY21B4.30), len: 171 aa. Conserved hypothetical protein, similar to part of AB010956|AB010956_1 metal-activated pyridoxal enzyme from Arthrobacter sp. (379 aa), FASTA scores: opt: 187, E(): 0.00026, (29.0% identity in 162 aa overlap).; hypothetical protein	1589386..1589901	Mycobacterium tuberculosis H37Rv	886692
NP_215930.1	CDS	Rv1414	NC_000962.2	1589891	1590292	D	Rv1414, (MTCY21B4.31), len: 133 aa. Conserved hypothetical protein, similar to C-terminal part of AB010956|AB010956_1 novel metal-activated pyridoxal enzyme from Arthrobacter sp. (379 aa), FASTA scores: opt: 163, E(): 0.00063, (32.1% identity in 112 aa overlap). Rv1413 is similar to N-terminal part of same enzyme suggesting possible frameshift. Sequence has been checked and no errors found, it is identical in Mycobacterium bovis strain AF2122/97 and in Mycobacterium tuberculosis CDC1551.; hypothetical protein	1589891..1590292	Mycobacterium tuberculosis H37Rv	886696
NP_215931.1	CDS	ribA2	NC_000962.2	1590397	1591674	D	bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein	1590397..1591674	Mycobacterium tuberculosis H37Rv	886694
NP_215932.1	CDS	ribH	NC_000962.2	1591689	1592153	D	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase	1591689..1592153	Mycobacterium tuberculosis H37Rv	886681
NP_215933.1	CDS	Rv1417	NC_000962.2	1592150	1592614	D	Rv1417, (MTCY21B4.35), len: 154 aa. Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa overlap).; hypothetical protein	1592150..1592614	Mycobacterium tuberculosis H37Rv	886704
NP_215934.1	CDS	lprH	NC_000962.2	1592639	1593325	D	Rv1418, (MTCY21B4.36), len: 228 aa. Probable lprH, lipoprotein. Contains N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013).; lipoprotein LprH	1592639..1593325	Mycobacterium tuberculosis H37Rv	886687
NP_215935.1	CDS	Rv1419	NC_000962.2	1593505	1593978	D	Rv1419, (MTCY21B4.37), len: 157 aa. Hypothetical unknown protein.; hypothetical protein	1593505..1593978	Mycobacterium tuberculosis H37Rv	886683
NP_215936.1	CDS	uvrC	NC_000962.2	1594042	1595982	D	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C	1594042..1595982	Mycobacterium tuberculosis H37Rv	886672
NP_215937.1	CDS	Rv1421	NC_000962.2	1595979	1596884	D	Rv1421, (MTCY21B4.39), len: 301 aa. Conserved hypothetical protein, similar to many hypothetical proteins e.g. YHBJ_ECOLI|P33995 hypothetical 32.5 kd protein from Escherichia coli (284 aa), FASTA scores: opt: 648, E(): 6.3e-36, (38.7% identity in 282aa overlap).; hypothetical protein	1595979..1596884	Mycobacterium tuberculosis H37Rv	886676
NP_215938.1	CDS	Rv1422	NC_000962.2	1596881	1597909	D	Rv1422, (MTCY21B4.40), len: 342 aa. Conserved hypothetical protein, similar to many hypothetical proteins e.g. YAMB_THETU|P38541 Thermoanaerobacterium thermosulfurigenes (323 aa), FASTA scores: opt: 519, E(): 1.6e-25, (33.1% identity in 320 aa overlap); and AF106003|AF106003_3 Streptomyces coelicolor (363 aa), FASTA scores: opt: 1047, E(): 0, (54.5% identity in 308 aa overlap).; hypothetical protein	1596881..1597909	Mycobacterium tuberculosis H37Rv	886670
NP_215939.1	CDS	whiA	NC_000962.2	1597906	1598883	D	Rv1423, (MTCY21B4.41-MTCY493.31c), len: 325 aa. Putative whiA, transcriptional regulator, probably equivalent to AL035591|SCC54.10 whiA protein from Streptomyces coelicolor (328 aa), FASTA scores: opt: 1505, E(): 0, (70.4% identity in 324 aa overlap). Also some similarity to O06975|YVCL hypothetical protein from Bacillus subtilis (316 aa), FASTA scores: E(): 1.8e-0 8, (25.7% identity in 304 aa overlap).; transcriptional regulatory protein WHIA	1597906..1598883	Mycobacterium tuberculosis H37Rv	886674
NP_215940.1	CDS	Rv1424c	NC_000962.2	1598893	1599654	R	Rv1424c, (MTCY21B4.42c,MTCY493.30), len: 253 aa. Possible membrane protein, contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.; hypothetical protein	complement(1598893..1599654)	Mycobacterium tuberculosis H37Rv	886685
NP_215941.1	CDS	Rv1425	NC_000962.2	1599658	1601037	D	Rv1425, (MTCY21B4.43,MTCY493.29c), len: 459 aa. Conserved hypothetical protein, similar to many M. tuberculosis hypothetical proteins e.g. Rv3740c, Rv3734c, Rv1760, etc.; hypothetical protein	1599658..1601037	Mycobacterium tuberculosis H37Rv	886668
NP_215942.1	CDS	lipO	NC_000962.2	1601059	1602321	R	Rv1426c, (MTCY493.28), len: 420 aa. Possible Lipo, esterase (EC 3.1.-.-), similar to several Mycobacterium tuberculosis hypothetical lipases and esterases e.g. Rv1399c, Rv2284, etc. Also similar in central region to AAAD_HUMAN|P22760 human arylacetamide deacetylase (398 aa), FASTA scores: opt:210, E(): 7.6e-07, (29.3% identity in 191 aa overlap).; esterase LipO	complement(1601059..1602321)	Mycobacterium tuberculosis H37Rv	886660
NP_215943.1	CDS	fadD12	NC_000962.2	1602321	1603928	R	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	complement(1602321..1603928)	Mycobacterium tuberculosis H37Rv	886679
NP_215944.1	CDS	Rv1428c	NC_000962.2	1603932	1604759	R	Rv1428c, (MTCY493.26), len: 275 aa. Conserved hypothetical protein, some similarity to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0502|YV29_MYCTU|Q11167 (358 aa), FASTA scores: opt: 355, E(): 5e-16, (32.6% identity in 273 aa overlap); and Rv1920.; hypothetical protein	complement(1603932..1604759)	Mycobacterium tuberculosis H37Rv	886656
NP_215945.1	CDS	Rv1429	NC_000962.2	1604878	1606146	D	Rv1429, (MTCY493.25c), len: 422 aa. Conserved hypothetical protein, some similarity to transcriptional regulator proteins e.g. CDAR_ECOLI|P37047 Carbohydrate diacid regulator from Escherichia coli (391 aa), FASTA scores: opt: 210, E(): 3e-06, (27.7% identity in 296 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv2370c, Rv1194c, Rv1453, Rv2242, and Rv1186c.; hypothetical protein	1604878..1606146	Mycobacterium tuberculosis H37Rv	886658
YP_177810.1	CDS	PE16	NC_000962.2	1606386	1607972	D	Rv1430, (MTCY493.24c), len: 528 aa. Member of the Mycobacterium tuberculosis PE family of proteins (see citation below), e.g. Y0D4_MYCTU|Q50594 (55.9% identity in 127 aa overlap). The C-terminus shows similarity to Q49633|LEPB1170_F3_112 hypothetical Mycobacterium leprae protein (391 aa), FASTA scores: opt: 342, E(): 1.2e-13, (29.8% identity in 292 aa overlap). Possible TMhelix aa 500-522.; PE family protein	1606386..1607972	Mycobacterium tuberculosis H37Rv	886652
NP_215947.1	CDS	Rv1431	NC_000962.2	1608083	1609852	D	Rv1431, (MTCY493.23c), len: 589 aa. Conserved membrane protein, shows strong similarity to another M. tuberculosis hypothetical protein Rv1132|MTCY22G8.21 (48.2% identity in 585 aa overlap).; hypothetical protein	1608083..1609852	Mycobacterium tuberculosis H37Rv	886662
NP_215948.1	CDS	Rv1432	NC_000962.2	1609849	1611270	D	Rv1432, (MTCY493.22c), len: 473 aa. Probable dehydrogenase (EC 1.-.-.-), shows strong simlarity to P49_STRLI|P06108 p49 protein from Streptomyces lividans (469 aa), FASTA scores: opt: 1362, E(): 0, (44.9% identity in 474 aa overlap); and weak simlarity to other dehydrogenases.; dehydrogenase	1609849..1611270	Mycobacterium tuberculosis H37Rv	886643
NP_215949.1	CDS	Rv1433	NC_000962.2	1611434	1612249	D	Rv1433, (MTCY493.21c), len: 271 aa. Possible exported protein with N-terminal signal sequence, highly similar to Q49706 hypothetical protein from Mycobacterium leprae (271 aa), FASTA scores: opt: 1341, E(): 0, (68.3% identity in 271 aa overlap). Also shows similarity to M. tuberculosis lipoprotein Rv2518c|MTV009.03c lppS (408 aa) (40.0% identity in 230 aa overlap); and others e.g. Rv0116c, Rv0192, Rv2518c, Rv0483.; hypothetical protein	1611434..1612249	Mycobacterium tuberculosis H37Rv	886649
NP_215950.1	CDS	Rv1434	NC_000962.2	1612256	1612393	D	Rv1434, (MTCY493.20c), len: 45 aa. Hypothetical unknown protein.; hypothetical protein	1612256..1612393	Mycobacterium tuberculosis H37Rv	886634
NP_215951.1	CDS	Rv1435c	NC_000962.2	1612342	1612950	R	Rv1435c, (MTCY493.19), len: 202 aa. Probable conserved Pro-, Gly-, Val-rich secreted protein (see citation below) with a N-terminal signal sequence. Similar at C-terminus to AF017099|AF017099_1 Mycobacterium tuberculosis pGB1 (87 aa), FASTA scores: opt: 550, E(): 2.3e-17, (97.7% identity in 86 aa overlap). Shows some similarity to N-terminus of CPN_DROME|Q02910 calphotin. drosophila melanogaster (865 aa), FASTA scores: opt: 266, E(): 2.5e-05, (37.2% identity in 191 aa overlap). Contains at least five 7 aa imperfect repeats. Also shows similarity to other Mycobacterium tuberculosis proteins e.g. MTCI237.20c (34.7% identity in 193 aa overlap), MTCI65.25c (36.9% identity in 160 aa overlap) and MTCI65.24c (34.2% identity in 196 aa overlap).; proline, glycine, valine-rich secreted protein	complement(1612342..1612950)	Mycobacterium tuberculosis H37Rv	886653
NP_215952.1	CDS	gap	NC_000962.2	1613307	1614326	D	catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase	1613307..1614326	Mycobacterium tuberculosis H37Rv	886632
NP_215953.1	CDS	pgk	NC_000962.2	1614329	1615567	D	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase	1614329..1615567	Mycobacterium tuberculosis H37Rv	886636
NP_215954.1	CDS	tpiA	NC_000962.2	1615564	1616349	D	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase	1615564..1616349	Mycobacterium tuberculosis H37Rv	886628
NP_215955.1	CDS	Rv1439c	NC_000962.2	1616961	1617386	R	Rv1439c, (MTCY493.15), len: 141 aa. Hypothetical unknown protein.; hypothetical protein	complement(1616961..1617386)	Mycobacterium tuberculosis H37Rv	886630
NP_215956.2	CDS	secG	NC_000962.2	1617837	1618070	D	Rv1440, (MTCY493.14c), len: 77 aa. Probable secG, protein-export membrane protein (translocase subunit) (see citation below), similar to many e.g. P38388|SECG_MYCLE PROBABLE PROTEIN-EXPORT MEMBRANE (77 aa), FASTA scores: opt: 450, E(): 6.7e-24, (96.1% identity in 77 aa overlap). Start changed since original submission (-40 aa). PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG AND SECY|Rv0732.; preprotein translocase subunit SecG	1617837..1618070	Mycobacterium tuberculosis H37Rv	886624
YP_177811.1	CDS	PE_PGRS26	NC_000962.2	1618209	1619684	R	Rv1441c, (MTCY493.13), len: 491 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002), similar to Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kDa protein (498 aa), fasta scores: opt: 1625, E(): 0, (55.2% identity in 518 aa overlap).; PE-PGRS family protein	complement(1618209..1619684)	Mycobacterium tuberculosis H37Rv	886626
NP_215958.1	CDS	bisC	NC_000962.2	1619791	1622091	D	Rv1442, (MTCY493.12c), len: 766 aa. Probable bisC, Biotin sulfoxide reductase (EC 1.-.-.-), similar to BISC_ECOLI|P20099 biotin sulfoxide reductase from Escherichia coli (739 aa), FASTA scores: opt: 1271, E():0, (40.2% identity in 744 aa overlap).; biotin sulfoxide reductase	1619791..1622091	Mycobacterium tuberculosis H37Rv	886620
NP_215959.1	CDS	Rv1443c	NC_000962.2	1622207	1622692	R	Rv1443c, (MTCY493.11), len: 161 aa. Hypothetical unknown protein.; hypothetical protein	complement(1622207..1622692)	Mycobacterium tuberculosis H37Rv	886622
NP_215960.1	CDS	Rv1444c	NC_000962.2	1623287	1623697	R	Rv1444c, (MTCY493.10), len: 136 aa. Hypothetical unknown protein.; hypothetical protein	complement(1623287..1623697)	Mycobacterium tuberculosis H37Rv	886616
NP_215961.1	CDS	devB	NC_000962.2	1623714	1624457	R	catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1,5-lactone; 6-phosphogluconolactonase	complement(1623714..1624457)	Mycobacterium tuberculosis H37Rv	886617
NP_215962.1	CDS	opcA	NC_000962.2	1624454	1625365	R	Rv1446c, (MTCY493.08), len: 303 aa. Putative opcA, OxPP cycle protein. Highly similar to S72774 B1496_F1_30 protein from Mycobacterium leprae (265 aa), FASTA scores: opt: 1056, E(): 0, (70.3% identity in 239 aa overlap). Also similar to OPCA_NOSS2|P48971 putative oxppcycle protein opca from Nostoc punctiforme (465 aa), fasta scores: opt: 177, E(): 7.3e-05, (23.4% identity in 321 aa overlap). AIDS IN G6PD ACTIVITY.; putative OXPP cycle protein OPCA	complement(1624454..1625365)	Mycobacterium tuberculosis H37Rv	886612
NP_215963.1	CDS	zwf2	NC_000962.2	1625418	1626962	R	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase	complement(1625418..1626962)	Mycobacterium tuberculosis H37Rv	886614
NP_215964.1	CDS	tal	NC_000962.2	1626959	1628080	R	catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase	complement(1626959..1628080)	Mycobacterium tuberculosis H37Rv	886606
NP_215965.1	CDS	tkt	NC_000962.2	1628097	1630199	R	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase	complement(1628097..1630199)	Mycobacterium tuberculosis H37Rv	886638
YP_177812.1	CDS	PE_PGRS27	NC_000962.2	1630638	1634627	R	Rv1450c, (MTCY493.04), len: 1329 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa protein (603 aa), fasta scores: opt: 2112, E(): 0, (56.5% identity in 630 aa overlap).; PE-PGRS family protein	complement(1630638..1634627)	Mycobacterium tuberculosis H37Rv	886605
NP_215967.1	CDS	ctaB	NC_000962.2	1635029	1635955	D	converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase	1635029..1635955	Mycobacterium tuberculosis H37Rv	886666
YP_177813.1	CDS	PE_PGRS28	NC_000962.2	1636004	1638229	R	Rv1452c, (MTCY493.02), len: 741 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa protein (603 aa), fasta scores: opt: 2090, E(): 0, (56.3% identity in 641 aa overlap).; PE-PGRS family protein	complement(1636004..1638229)	Mycobacterium tuberculosis H37Rv	886595
NP_215969.2	CDS	Rv1453	NC_000962.2	1638381	1639646	D	Rv1453, (MTCY493.01c), len: 421 aa. Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c, and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap). Start changed since first submission (-11 aa).; transcriptional activator protein	1638381..1639646	Mycobacterium tuberculosis H37Rv	886610
NP_215970.1	CDS	qor	NC_000962.2	1639674	1640660	R	Rv1454c, (MTV007.01c), len: 328 aa. Probable qor, quinone oxidoreductase (EC 1.6.5.5), simiar to U87282|RCU87282_2 quinone oxidoreductase from Rhodobacter capsulatus (323 aa), FASTA scores: opt: 849, E(): 0, (44.7% identity in 329 aa overlap). Also similar to MTCY180.06 Hypothetical protein from Mycobacterium tuberculosis (334 aa), FASTA scores: opt: 430, E(): 2e-14, (32.3% identity in 350 aa overlap). TBparse score is 0.887. Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature.; quinone reductase	complement(1639674..1640660)	Mycobacterium tuberculosis H37Rv	886589
NP_215971.1	CDS	Rv1455	NC_000962.2	1640680	1641543	D	Rv1455, (MTV007.02), len: 287 aa. Conserved hypothetical protein, some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). TBparse score is 0.915.; hypothetical protein	1640680..1641543	Mycobacterium tuberculosis H37Rv	886597
NP_215972.1	CDS	Rv1456c	NC_000962.2	1641493	1642425	R	Rv1456c, (MTV007.03c), len: 310 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.34 from Mycobacterium leprae (311 aa), FASTA scores: opt: 1607, E(): 0, (83.3% identity in 300 aa overlap). TBparse score is 0.886.; unidentified antibiotic-transport integral membrane ABC transporter	complement(1641493..1642425)	Mycobacterium tuberculosis H37Rv	886591
NP_215973.1	CDS	Rv1457c	NC_000962.2	1642537	1643322	R	Rv1457c, (MTV007.04c), len: 261 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.32 from Mycobacterium leprae (265 aa), FASTA scores: opt: 1415, E(): 0, (83.1% identity in 260 aa overlap). TBparse score is 0.877.; unidentified antibiotic-transport integral membrane ABC transporter	complement(1642537..1643322)	Mycobacterium tuberculosis H37Rv	886587
NP_215974.1	CDS	Rv1458c	NC_000962.2	1643319	1644260	R	Rv1458c, (MTV007.05c), len: 313 aa. Possible unidentified antibiotic-transport ATP-binding protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.31 from Mycobacterium leprae (315 aa), FASTA scores: opt: 1812, E(): 0, (88.0% identity in 308 aa overlap). Similar to AF027770|AF027770_7 ABC-type transporter in FxbA region in Mycobacterium smegmatis (284 aa), FASTA scores: opt: 1412, E(): 0, (85.1% identity in 248 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.874.; unidentified antibiotic-transport ATP-binding protein ABC transporter	complement(1643319..1644260)	Mycobacterium tuberculosis H37Rv	886582
NP_215975.1	CDS	Rv1459c	NC_000962.2	1644363	1646138	R	Rv1459c, (MTV007.06c), len: 591 aa. Possible conserved integral membrane protein, equivalent to MLCL536.30|Z99125 hypothetical protein from Mycobacterium leprae (593 aa), FASTA scores: opt: 1670, E(): 0, (78.6% identity in 585 aa overlap). Also similar to M. tuberculosis protein Rv2174|MTV021.07 (33.1% identity in 523 aa overlap).; integral membrane protein	complement(1644363..1646138)	Mycobacterium tuberculosis H37Rv	886585
NP_215976.2	CDS	Rv1460	NC_000962.2	1646186	1646992	D	Rv1460, (MTV007.07), len: 268 aa. Probable transcriptional regulatory protein. Equivalent to Z99125|MLCL536.29c hypothetical protein from Mycobacterium leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6% identity in 250 aa overlap). Possible helix-turn-helix motif between aa 68 - 89. Start changed since original submission. TBparse score is 0.904.; transcriptional regulatory protein	1646186..1646992	Mycobacterium tuberculosis H37Rv	886573
NP_215977.1	CDS	Rv1461	NC_000962.2	1646989	1649529	D	Rv1461, (MTV007.08), len: 846 aa. Conserved hypothetical protein. Equivalent of spliced protein from Mycobacterium leprae MLCL536.28c len: 869. Residues 1-253 represent N-extein, and 613-846 the C-extein. The intein present from residues 254 - 612 is different in sequence and site of the insertion from the one present in MLCL536.28c. FASTA scores: Z99125|MLCL536_23 Mycobacterium leprae cosmid L536 (869 aa), opt: 1498 E(): 0, (54.1% identity in 917 aa overlap). The mature protein is similar to Z99120|BSUB0017_150 hypothetical Bacillus subtilis protein (465 aa), FASTA scores: opt:1053, E(): 0, (34.8% identity in 821 aa overlap). The intein shows some similarity to inteins from U67548|MJU67548_6 Methanococcus jannaschii (895 aa), FASTA scores: opt: 181, E(): 0.00023, (25.2% identity in 274 aa overlap). TBparse score is 0.913.; hypothetical protein	1646989..1649529	Mycobacterium tuberculosis H37Rv	886609
NP_215978.1	CDS	Rv1462	NC_000962.2	1649526	1650719	D	Rv1462, (MTV007.09), len: 397 aa. Conserved hypothetical protein. Equivalent to MLCL536.27c|Z99125 hypothetical protein from Mycobacterium leprae (392 aa), FASTA scores: opt: 2059, E(): 0, (80.4% identity in 392 aa overlap). Also similar to nearby Mycobacterium tuberculosis hypothetical protein Rv1461. TBparse score is 0.873.; hypothetical protein	1649526..1650719	Mycobacterium tuberculosis H37Rv	886567
NP_215979.1	CDS	Rv1463	NC_000962.2	1650716	1651516	D	Rv1463, (MTV007.10), len: 266 aa. Probable conserved ATP-binding protein ABC transporter, equivalent to Z99125|MLCL536.26c putative ABC transporter ATP-binding protein from Mycobacterium leprae (260 aa), FASTA scores: opt: 1444, E(): 0, (86.0% identity in 267 aa overlap). Very similar to U38804|PPU38804_55 ATP-DEPENDENT TRANSPORTER YCF16 from PORPHYRA PURPUREA chloroplast (251 aa), FASTA scores: opt: 822, E(): 0, (52.4% identity in 248 aa overlap); and similar to others. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.872.; ABC transporter ATP-binding protein	1650716..1651516	Mycobacterium tuberculosis H37Rv	886571
NP_215980.1	CDS	csd	NC_000962.2	1651518	1652771	D	Rv1464, (MTV007.11), len: 417 aa. Probable csd, cysteine desulfurase (EC 4.4.1.- ). Equivalent to Q49690|MLCL536.25C cysteine desulfurase from Mycobacterium leprae (418 aa), FASTA scores: opt: 2333, E(): 0, (85.4% identity in 417 aa overlap); and similar to cysteine desulfurase from other organisms. Also similar to M. tuberculosis proteins Rv3025c|ISCS and Rv3778c. Contains PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. TBparse score is 0.881. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. CSD SUBFAMILY.; cysteine desulfurase	1651518..1652771	Mycobacterium tuberculosis H37Rv	886565
NP_215981.1	CDS	Rv1465	NC_000962.2	1652768	1653256	D	Rv1465, (MTV007.12), len: 162 aa. Possible nitrogen fixation related protein. Equivalent to Z99125|MLCL536.24c nitrogen fixation protein NIFU from Mycobacterium leprae (165 aa), FASTA scores: opt: 870, E(): 0, (81.8% identity in 165 aa overlap). Also similar to O32163|Z99120|NIFU_BACSU NifU-like protein from Bacillus subtilis (147 aa), FASTA scores: opt: 354, E(): 4.1e-17, (38.3% identity in 141 aa overlap) and to AL096839|SCC22.02 hypothetical protein from Streptomyces coelicolor (156 aa), FASTA scores: opt: 569, E(): 1.2e-31, (56.3% identity in 158 aa overlap). TBparse score is 0.898.; nitrogen fixation related protein	1652768..1653256	Mycobacterium tuberculosis H37Rv	886569
NP_215982.1	CDS	Rv1466	NC_000962.2	1653231	1653578	D	Rv1466, (MTV007.13), len: 115 aa. Conserved hypothetical protein. Equivalent to Z99125|MLCL536.23c hypothetical protein from Mycobacterium leprae (115 aa), FASTA scores: opt: 648, E(): 0, (81.7% identity in 115 aa overlap). Similar to ORF's downstream of sigma factors in Streptococcus mutans and Streptococcus pneumoniae e.g. O06451 ORF3 downstream of RpoD (SPDNAGCPO) (109 aa). Alternative TTG start possible at 13757 then avoids overlap with MTV007.12. TBparse score is 0.837.; hypothetical protein	1653231..1653578	Mycobacterium tuberculosis H37Rv	886561
NP_215983.1	CDS	fadE15	NC_000962.2	1653673	1655502	R	Rv1467c, (MTV007.14c), len: 609 aa. Probable fadE15, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to NP_302639.1|NC_002677 acyl-CoA dehydrogenase from Mycobacterium leprae (611 aa). Also highly similar to many e.g. T36481 probable acyl-CoA dehydrogenase (fragment) from Streptomyces coelicolor (491 aa) (has its N-terminus very shorter); NP_384640.1|NC_003047 PUTATIVE ACYL-CoA DEHYDROGENASE PROTEIN from Sinorhizobium meliloti (598 aa); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain specific) from Megasphaera elsdenii (383 aa), FASTA scores: E(): 2e-12, (25.4% identity in 410 aa overlap); etc. Also highly similar to fadE5|Rv0244c|MTV034.10c ACYL-CoA DEHYDROGENASE from Mycobacterium tuberculosis (611 aa); and similar to other proteins from Mycobacterium tuberculosis. TBparse score is 0.892.; acyl-CoA dehydrogenase FADE15	complement(1653673..1655502)	Mycobacterium tuberculosis H37Rv	886562
YP_177814.1	CDS	PE_PGRS29	NC_000962.2	1655609	1656721	R	Rv1468c, (MTV007.15c), len: 370 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). TBparse score is 0.856.; PE-PGRS family protein	complement(1655609..1656721)	Mycobacterium tuberculosis H37Rv	886556
NP_215985.1	CDS	ctpD	NC_000962.2	1656963	1658936	D	Rv1469, (MTV007.16), len: 657 aa. Probable ctpD, cation-transporting P-type ATPase D (transmembrane protein) (EC 3.6.3.-), highly similar to others e.g. T35947 probable cation-transporting ATPase from Streptomyces coelicolor (638 aa); NP_442633.1|NC_000911 cation-transporting ATPase (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (642 aa), FASTA scores: opt: 1438, E(): 0, (41.9% identity in 592 aa overlap); NP_389268.1|NC_000964 protein similar to heavy metal-transporting ATPase from Bacillus subtilis (637 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv3743c|MTV025.091c|CTPJ (660 aa). Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. TBparse score is 0.907.; cation transporter P-type ATPase D	1656963..1658936	Mycobacterium tuberculosis H37Rv	886578
NP_215986.1	CDS	trxA	NC_000962.2	1658980	1659354	D	Rv1470, (MTV007.17), len: 124 aa. Probable trxA, thioredoxin (EC 1.-.-.-), similar to many e.g. P12243|THI1_SYNP7 THIOREDOXIN 1 from Synechococcus sp. (106 aa), FASTA scores: opt: 201, E(): 9.2e-08, (35.4% identity in 99 aa overlap); etc. Highly similar to downstream ORF Rv1471|trxB1 probable thioredoxin from Mycobacterium tuberculosis (123 aa), FASTA scores: opt: 402, E(): 0, (54.4% identity in 114 aa overlap). TBparse score is 0.925. Warning: note that Rv3914|MT4033|MTV028.05|trxC can be alternatively named trxA.; thioredoxin TRXA	1658980..1659354	Mycobacterium tuberculosis H37Rv	886558
YP_177815.1	CDS	trxB1	NC_000962.2	1659370	1659741	D	Rv1471, (MTV007.18), len: 123 aa. Probable trxB1, thioredoxin (EC 1.-.-.-), similar to many bacterial thioredoxins e.g. P33636|THI2_ECOLI from Escherichia coli (139 aa), FASTA scores: opt: 290, E(): 1.8e-13, (44.3% identity in 97 aa overlap); etc. Highly similar to Rv1470|TrxA probable thioredoxin from Mycobacterium tuberculosis (124 aa), FASTA scores: opt: 402, E(): 1.2e-32, (54.4% identity in 114 aa overlap). Contains PS00194 Thioredoxin family active site. BELONGS TO THE THIOREDOXIN FAMILY. TBparse score is 0.882. Note that previously known as trxB.; trxB; thioredoxin TRXB1	1659370..1659741	Mycobacterium tuberculosis H37Rv	886554
NP_215988.1	CDS	echA12	NC_000962.2	1659763	1660620	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	1659763..1660620	Mycobacterium tuberculosis H37Rv	886547
NP_215989.1	CDS	Rv1473	NC_000962.2	1660656	1662284	D	Rv1473, (MTV007.20), len: 542 aa. Possible macrolide-transport ATP-binding protein ABC transporter (see citation below), possibly in EF-3 subfamily. Similar to many ABC-transporters e.g. D90909_48|YHES_HAEIN from Synechocystis sp. strain PCC6803 (574 aa), FASTA scores: opt: 870, E(): 0, (33.3% identity in 525 aa overlap); P44808|YHES_HAEIN from Haemophilus influenzae (638 aa), FASTA scores: opt: 706, E(): 0, (33.7% identity in 517 aa overlap); etc. Contains two PS00017 ATP/GTP-binding site motif A (P-loop), and two PS00211 ABC transporter family signatures. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.888.; macrolide ABC transporter ATP-binding protein	1660656..1662284	Mycobacterium tuberculosis H37Rv	886549
YP_177644.1	CDS	Rv1473A	NC_000962.2	1662381	1662572	D	Rv1473A, len: 63 aa. Possible transcriptional regulator, CDS predicted by GC plot. Similar to SCI8.24c|AL132644_24 putative transcriptional regulator from Streptomyces coelicolor (73 aa), FASTA scores: opt: 210, E(): 1.5e-08, (56.15% identity in 57 aa overlap).; transcriptional regulatory protein	1662381..1662572	Mycobacterium tuberculosis H37Rv	3205054
NP_215990.1	CDS	Rv1474c	NC_000962.2	1662641	1663204	R	Rv1474c, (MTV007.21c), len: 187 aa. Probable transcription regulator, equivalent to AF0021|AF002133_1 transcriptional regulator from Mycobacterium avium strain GIR10 (82 aa), FASTA scores: opt: 490, E(): 6.7e-26, (92.5% identity in 80 aa overlap). Also similar to Q59431|UIDR_ECOLI UID OPERON REPRESSOR (GUS OPERON) from Escherichia coli (196 aa), FASTA scores: opt: 192, E(): 5.8e-06, (28.5% identity in 172 aa overlap). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Helix turn helix motif predicted at aa 33-54 (+3.40 SD).; transcriptional regulatory protein	complement(1662641..1663204)	Mycobacterium tuberculosis H37Rv	886543
NP_215991.1	CDS	acn	NC_000962.2	1663215	1666046	R	Catalyzes the conversion of citrate to isocitrate; aconitate hydratase	complement(1663215..1666046)	Mycobacterium tuberculosis H37Rv	886545
NP_215992.1	CDS	Rv1476	NC_000962.2	1666204	1666764	D	Rv1476, (MTV007.23), len: 186 aa. Possibly membrane protein, TMhelix 138-60. TBparse score is 0.926.; hypothetical protein	1666204..1666764	Mycobacterium tuberculosis H37Rv	886539
NP_215993.1	CDS	Rv1477	NC_000962.2	1666990	1668408	D	Rv1477, (MTV007.24), len: 472 aa. Hypothetical Invasion protein. Possibly exported protein with unusually long signal sequence. The last 277 residues are nearly identical to those of AF0060|AF006054_1 hypothetical invasion protein INV1 from Mycobacterium tuberculosis (277 aa), FASTA scores: opt: 1833, E(): 0, (98.2% identity in 277 aa overlap); also very similar to AF0021|AF002133_4 invasin 1 protein from Mycobacterium avium (273 aa), FASTA scores: opt: 1452, E(): 0, (78.1% identity in 279 aa overlap). Similar to Rv1566c|MTCY336.37|Z95586 Mycobacterium tuberculosis cosmid (230 aa), FASTA scores: opt: 528, E(): 4.4e-20, (52.0% identity in 150 aa overlap); and weakly similar to p60 proteins of Listeria spp throughout its length e.g. M80351|LISIAPB_1 Listeria monocytogenes iap-related protein (478 aa), FASTA scores: opt: 251, E(): 8e-06, (24.4% identity in 487 aa overlap). C-terminal domain highly similar to next orf Rv1478|MTV007.25.; invasion protein	1666990..1668408	Mycobacterium tuberculosis H37Rv	886541
NP_215994.1	CDS	Rv1478	NC_000962.2	1668419	1669144	D	Rv1478, (MTV007.25), len: 241 aa. Hypothetical Invasion protein. Possibly exported protein, nearly identical to AF0060|AF006054_2 hypothetical invasion protein INV2 of Mycobacterium tuberculosis (240 aa), FASTA scores: opt: 1509, E(): 0, (95.0% identity in 241 aa overlap); very similar to AF0021|AF002133_5 hypothetical invasion protein INV2 from Mycobacterium avium (244 aa), FASTA scores: opt: 1269, E():0, (78.0% identity in 246 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY336.37 and weakly similar to C-terminal segment of p60 proteins of Listeria spp.e.g. Q01836|P60_LISIN PROTEIN P60 PRECURSOR (481 aa), FASTA scores: opt: 241, E():4e-07, (37.7% identity in 122 aa overlap). Highly similar to C-terminal domain of preceeding ORF Rv1477|MTV007.24 (472 aa), FASTA scores: opt: 864, E(): 0, (60.1% identity in 213 aa overlap). TBparse score is 0.910.; invasion protein	1668419..1669144	Mycobacterium tuberculosis H37Rv	886535
YP_177816.1	CDS	moxR1	NC_000962.2	1669283	1670416	D	Rv1479, (MTV007.26), len: 377 aa. Probable moxR1, transcriptional regulatory protein, similar to X96434|BBGIDBMOX_2 moxR regulator from Borrelia burgdorferi (329 aa), FASTA scores: opt: 850, E():0, (43.5% identity in 317 aa overlap); and P. denitrificans. Highly similar to MoxR homologs of Mycobacterium tuberculosis and Mycobacterium avium (but these both differ at C-terminus) e.g. Rv3692, Rv3164c, and AF0021|AF002133_6 Mycobacterium avium strain GIR10 (309 aa), FASTA scores: opt: 1181, E(): 0, (83.7% identity in 227 aa overlap). Also similar to O33173|AF006054 MoxR fragment from Mycobacterium tuberculosis (211 aa), FASTA scores: opt: 1305, E(): 0, (94.3% identity in 212 aa overlap). TBparse score is 0.889. Note that previously known as moxR.; moxR; transcriptional regulatory protein MOXR1	1669283..1670416	Mycobacterium tuberculosis H37Rv	886537
NP_215996.1	CDS	Rv1480	NC_000962.2	1670413	1671366	D	Rv1480, (MTV007.27,MTCY227.01), len: 317 aa. Conserved hypothetical protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa Mycobacterium avium protein MAV169 (169 aa), FASTA scores: opt: 642, E(): 0, (84.2% identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693. TBparse score is 0.886.; hypothetical protein	1670413..1671366	Mycobacterium tuberculosis H37Rv	886531
NP_215997.1	CDS	Rv1481	NC_000962.2	1671377	1672384	D	Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa), FASTA scores: opt: 1904, E(): 0, (89.0% identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5% identity in 340 aa overlap).; hypothetical protein	1671377..1672384	Mycobacterium tuberculosis H37Rv	886533
NP_215998.2	CDS	Rv1482c	NC_000962.2	1672457	1673299	R	Rv1482c, (MTCY277.03c), len: 280 aa. Conserved hypothetical protein, highly similar to O07396|AF002133 Mycobacterium avium protein MAV346 (346 aa), FASTA scores: E(): 0, (65.2% identity in 342 aa overlap); slight similarity to GRPE_ECOLI|P09372 heat shock protein from E. coli (197 aa), FASTA scores: opt: 139, E(): 0.012, (28.3% identity in 159 aa overlap). Similar to Mycobacterium tuberculosis hypothetical proteins Rv3517, Rv3555c, Rv3714c, Rv1073, etc. Start changed since first submission (-59 aa).; hypothetical protein	complement(1672457..1673299)	Mycobacterium tuberculosis H37Rv	886526
NP_215999.1	CDS	fabG1	NC_000962.2	1673440	1674183	D	Rv1483, (MTCY277.04), len: 247 aa. fabG1 (alternate gene name: mabA), 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) (see citations below), equivalent to O07399|FABG_MYCAV 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE from Mycobacterium avium (255 aa); P71534|FABG_MYCSM 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE from Mycobacterium smegmatis (255 aa); and NP_302228.1|NC_002677 3-oxoacyl-[ACP] reductase (aka MabA) from Mycobacterium leprae (253 aa). Also highly similar to many e.g. T36779 probable 3-oxacyl-(acyl-carrier-protein) reductase from Streptomyces coelicolor (234 aa); FABG_ECOLI|P25716|NP_415611.1|NC_000913 3-oxoacyl-[acyl-carrier-protein] reductase from Escherichia coli strain K12 (244 aa), FASTA scores: opt: 664, E(): 6.8e-35, (44.4% identity in 241 aa overlap); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; mabA; 3-oxoacyl-[acyl-carrier protein] reductase FabG1	1673440..1674183	Mycobacterium tuberculosis H37Rv	886551
NP_216000.1	CDS	inhA	NC_000962.2	1674202	1675011	D	Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase	1674202..1675011	Mycobacterium tuberculosis H37Rv	886523
NP_216001.1	CDS	hemH	NC_000962.2	1675017	1676051	D	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase	1675017..1676051	Mycobacterium tuberculosis H37Rv	886525
NP_216002.2	CDS	Rv1486c	NC_000962.2	1676017	1676883	R	Rv1486c, (MTCY277.07c), len: 288 aa. Conserved hypothetical protein, highly similar to YS07_MYCAV|O07402 hypothetical 33.5 kDa protein mav321 from Mycobacterium avium (320 aa), FASTA scores: opt: 1217, E(): 0, (71.1% identity in 315 aa overlap). Weak similarity to AL079332|SCI5.07 hypothetical protein from Streptomyces coelicolor (259 aa), FASTA scores: opt: 131, E(): 0.29, (32.3% identity in 279 aa overlap). Start changed since original submission.; hypothetical protein	complement(1676017..1676883)	Mycobacterium tuberculosis H37Rv	886519
NP_216003.1	CDS	Rv1487	NC_000962.2	1676941	1677375	D	Rv1487, (MTCY277.08), len: 144 aa. Conserved membrane protein. Highly similar to O07404|AF002133 MAV145 from Mycobacterium avium (145 aa), FASTA scores: opt: 667, E(): 0, (72.5% identity in 142 aa overlap). Also similar to AL079332|SCI5.05 hypothetical protein from Streptomyces coelicolor (143 aa), FASTA scores: opt: 344, E(): 1.3e-15, (44.8% identity in 134 aa overlap).; hypothetical protein	1676941..1677375	Mycobacterium tuberculosis H37Rv	886521
NP_216004.1	CDS	Rv1488	NC_000962.2	1677397	1678542	D	Rv1488, (MTCY277.09), len: 381 aa. Possible exported conserved protein; contains possible N-terminal signal sequence. Similar to YBBK_ECOLI|P77367 hypothetical protein ybbK from Escherichia coli (305 aa), FASTA scores: opt: 716, E(): 0, (37.1% identity in 307 aa overlap). Similar to stomatin-like proteins e.g. AF065260|AF065260_1 Clostridium difficile (320 aa), FASTA scores: opt: 767, E(): 0, (42.3% identity in 307 aa overlap).; hypothetical protein	1677397..1678542	Mycobacterium tuberculosis H37Rv	886515
YP_177645.1	CDS	Rv1489	NC_000962.2	1678552	1678908	D	Rv1489, len: 118 aa. Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium avium subsp. paratuberculosis and Streptomyces coelicolor e.g. AJ250017_1 insertion sequence IS900, Locus 3, putative invasion protein from M. paratuberculosis (138 aa), FASTA scores: opt: 120, E(): 0.26, (34.375% identity in 96 aa overlap); SCD6.11c|AL353815_11 possible integral membrane protein from Streptomyces coelicolor (136 aa), FASTA scores: opt: 106, E(): 2.2, (35.9% identity in 103 aa overlap). ORF predicted by GC plot. Replaces previous Rv1489c on other strand.; hypothetical protein	1678552..1678908	Mycobacterium tuberculosis H37Rv	3205064
YP_177646.1	CDS	Rv1489A	NC_000962.2	1678942	1679172	D	Rv1489A, len: 76 aa. Conserved hypothetical protein, similar to part of alpha subunit of many methylmalonyl-CoA mutases ( 750 aa). Size difference suggests possible gene fragment although Mycobacterium tuberculosis has intact methylmalonyl-CoA mutase gene. P71774|MUTB_MYCTU PROBABLE METHYLMALONYL-CoA MUTASE from Mycobacterium tuberculosis (750 aa), FASTA scores: opt: 258, E(): 3.2e-10, (73.35% identity in 60 aa overlap). ORF predicted by GC plot.; hypothetical protein	1678942..1679172	Mycobacterium tuberculosis H37Rv	3205065
NP_216006.1	CDS	Rv1490	NC_000962.2	1679322	1680629	D	Rv1490, (MTCY277.12), len: 435 aa. Probable membrane protein.; hypothetical protein	1679322..1680629	Mycobacterium tuberculosis H37Rv	886511
NP_216007.1	CDS	Rv1491c	NC_000962.2	1681208	1681966	R	Rv1491c, (MTCY277.13c), len: 252 aa. Conserved membrane protein. Similar to hypothetical proteins from many organisms e.g. YDJZ_ECOLI|P76221 Escherichia coli (235 aa), FASTA scores: opt: 223, E():6.7 e-07, (31.7% identity in 145 aa overlap); AL133252|SCE46.15 Streptomyces coelicolor (249 aa), FASTA scores: opt: 378, E(): 1.5e-17, (39.1% identity in 169 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical protein Rv0625c.; hypothetical protein	complement(1681208..1681966)	Mycobacterium tuberculosis H37Rv	886513
NP_216008.1	CDS	mutA	NC_000962.2	1682157	1684004	D	Rv1492, (MTCY277.14), len: 615 aa. Probable mutA, Methylmalonyl-CoA mutase small-subunit (EC 5.4.99.2), strong similarity to e.g. MUTA_STRCM|Q05064 methylmalonyl-CoA mutase beta-subunit from Streptomyces cinnamonensis (616 aa), FASTA scores: opt: 1512, E(): 0, (45.9% identity in 628 aa overlap). Contains PS00213 Lipocalin signature, PS00544 Methylmalonyl-CoA mutase signature. BELONGS TO THE METHYLMALONYL-CoA MUTASE FAMILY.; methylmalonyl-CoA mutase small subunit	1682157..1684004	Mycobacterium tuberculosis H37Rv	886507
NP_216009.1	CDS	mutB	NC_000962.2	1684005	1686257	D	MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase	1684005..1686257	Mycobacterium tuberculosis H37Rv	886509
NP_216010.1	CDS	Rv1494	NC_000962.2	1686271	1686573	D	Rv1494, (MTCY277.16), len: 100 aa. Hypothetical unknown protein.; hypothetical protein	1686271..1686573	Mycobacterium tuberculosis H37Rv	886502
NP_216011.1	CDS	Rv1495	NC_000962.2	1686570	1686887	D	Rv1495, (MTCY277.17), len: 105 aa. Conserved hypothetical protein, some similarity to Rv1942c|MTCY09F9.22 hypothetical protein from Mycobacterium tuberculosis (109 aa) (0.7% identity in 101 aa overlap) and Rv0659c, Rv1102c.; hypothetical protein	1686570..1686887	Mycobacterium tuberculosis H37Rv	886504
NP_216012.1	CDS	Rv1496	NC_000962.2	1686884	1687888	D	functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase	1686884..1687888	Mycobacterium tuberculosis H37Rv	886496
NP_216013.1	CDS	lipL	NC_000962.2	1687941	1689230	D	Rv1497, (MTCY277.19), len: 429 aa. Probable LipL, esterase (EC 3.1.-.-), very similar to Mycobacterium tuberculosis hypothetical esterases and penicillin binding proteins e.g. Rv1923, Rv2463, Rv3775, etc. Also similar to G151214|M68491 esterase estA from Pseudomonas sp (389 aa), FASTA scores: opt: 604, E(): 1e-31, (34.4% identity in 389 aa overlap).; esterase LipL	1687941..1689230	Mycobacterium tuberculosis H37Rv	886575
NP_216014.1	CDS	Rv1498c	NC_000962.2	1689303	1689920	R	Rv1498c, (MTCY277.20c), len: 205 aa. Probable methyltransferase (EC 2.1.1.-). Similar to G2792343|AF040571 METHYLTRANSFERASE from AMYCOLATOPSIS MEDITERRANEI (272 aa), FASTA scores: E(): 5.1e-11, (32.3% identity in 124 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.; methyltransferase	complement(1689303..1689920)	Mycobacterium tuberculosis H37Rv	886503
YP_177647.1	CDS	Rv1498A	NC_000962.2	1690134	1690346	R	Rv1498A, len: 70 aa. Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. from Streptomyces coelicolor, Sinorhizobium meliloti and Pseudomonas aeruginosa.; hypothetical protein	complement(1690134..1690346)	Mycobacterium tuberculosis H37Rv	3205040
NP_216015.2	CDS	Rv1499	NC_000962.2	1690407	1690805	D	Rv1499, (MTCY277.21), len: 132 aa. Hypothetical unknown protein; was initially longer but has been shortened (-24 aa) owing to overlap with Rv1498A.; hypothetical protein	1690407..1690805	Mycobacterium tuberculosis H37Rv	886494
NP_216016.1	CDS	Rv1500	NC_000962.2	1690850	1691878	D	Rv1500, (MTCY277.22), len: 342 aa. Probable glycosyltransferase (EC 2.-.-.- ), hydrophobic domain near C-terminus. Some similarity to putative glycosyl-transferases from Bacillus subtilis e.g. O34319|YKCC_BACSU (323 aa), opt: 490, E(): 6.1e-25, (28.85% identity in 312 aa overlap) and to N-acetyl glucosamine transferases. Also similar to G1001347 hypothetical 36.7 kDa protein (318 aa), FASTA scores: opt: 523, E(): 7.2e-26, (30.6% identity in 307 aa overlap).; glycosyltransferase	1690850..1691878	Mycobacterium tuberculosis H37Rv	886492
NP_216017.1	CDS	Rv1501	NC_000962.2	1691890	1692711	D	Rv1501, (MTCY277.23), len: 273 aa. Conserved hypothetical protein, some similarity to O06374|Rv3633|MTCY15C10.19C hypothetical protein from Mycobacterium tuberculosis, FASTA scores: E(): 3.9e-10, (27.5% identity in 280 aa overlap).; hypothetical protein	1691890..1692711	Mycobacterium tuberculosis H37Rv	886499
NP_216018.1	CDS	Rv1502	NC_000962.2	1692924	1693823	D	Rv1502, (MTCY277.24), len: 299 aa. Hypothetical unknown protein.; hypothetical protein	1692924..1693823	Mycobacterium tuberculosis H37Rv	886486
NP_216019.1	CDS	Rv1503c	NC_000962.2	1693996	>1694544	R	Rv1503c, (MTCY277.25c), len: 182 aa. Conserved hypothetical protein, similar to C-terminal region of P27833|RFFA_ECOLI LIPOPOLYSACCHARIDE BIOSYNTHESIS PROTEIN from Escherichia coli (376 aa), FASTA scores: opt: 565, E(): 0, (49.4% identity in 170 aa overlap); Rv1503c and Rv1504c are both similar to RFFA_ECOLI but are separated by a stop codon, sequence appears to be correct so possible pseudogene.; hypothetical protein	complement(1693996..>1694544)	Mycobacterium tuberculosis H37Rv	886488
NP_216020.1	CDS	Rv1504c	NC_000962.2	1694545	1695144	R	Rv1504c, (MTCY277.26c), len: 199 aa. Conserved hypothetical protein, similar to N-terminal region of P27833|RFFA_ECOLI LIPOPOLYSACCHARIDE BIOSYNTHESIS PROTEIN from Escherichia coli (376 aa), FASTA scores: opt: 863, E(): 0, (68.0% identity in 194 aa overlap); Rv1503c and Rv1504c are similar to RFFA_ECOLI but are separated by a stop codon, sequence appears to be correct so possible pseudogene.; hypothetical protein	complement(1694545..1695144)	Mycobacterium tuberculosis H37Rv	886481
NP_216021.1	CDS	Rv1505c	NC_000962.2	1695281	1695946	R	Rv1505c, (MTCY277.27c), len: 221 aa. Conserved hypothetical protein, some similarity to hypothetical proteins and glycosylases e.g. P71063|O08181 HYPOTHETICAL 22.5 kDa PROTEIN YVFD from Bacillus subtilis (216 aa), FASTA scores: E(): 2.4e-08, (25.5% identity in 196 aa overlap).; hypothetical protein	complement(1695281..1695946)	Mycobacterium tuberculosis H37Rv	886483
NP_216022.1	CDS	Rv1506c	NC_000962.2	1695943	1696443	R	Rv1506c, (MTCY277.28c), len: 166 aa. Hypothetical unknown protein.; hypothetical protein	complement(1695943..1696443)	Mycobacterium tuberculosis H37Rv	886479
NP_216023.1	CDS	Rv1507c	NC_000962.2	1696727	1697422	R	Rv1507c, (MTCY277.29c), len: 231 aa. Conserved hypothetical protein. Similar to AJ007747|BBR007747_6 Hypothetical protein BbLPS1.06 from Bordetella bronchiseptica cosmid (239 aa), FASTA scores: opt: 362, E(): 1.3e-17, (30.8% identity in 221 aa overlap).; hypothetical protein	complement(1696727..1697422)	Mycobacterium tuberculosis H37Rv	886477
YP_177648.1	CDS	Rv1507A	NC_000962.2	1697356	1697859	D	Rv1507A, len: 167 aa. Hypothetical unknow protein. Shows weak similarity with C-terminus of Q9XHQ7|CDA9 CYTIDINE DEAMINASE 9 from Arabidopsis thaliana (Mouse-ear cress) (298 aa), FASTA scores: opt: 104, E(): 4.2, (33.6% identity in 133 aa overlap), BLASTP scores: Score: 77, Identities: 39/133 (29%), Positives: 62/133 (46%).; hypothetical protein	1697356..1697859	Mycobacterium tuberculosis H37Rv	3205095
NP_216024.1	CDS	Rv1508c	NC_000962.2	1698095	1699894	R	Rv1508c, (MTCY277.30c), len: 599 aa. Probable membrane protein.; hypothetical protein	complement(1698095..1699894)	Mycobacterium tuberculosis H37Rv	886078
YP_177649.1	CDS	Rv1508A	NC_000962.2	1699866	1700228	D	Rv1508A, len: 120 aa. Conserved hypothetical protein, highly similar to central part of glycosyl transferases from various mycobacteria and eubacteria e.g. P71790|MTCY277.33|Rv1511 Hypothetical protein from M. tuberculosis (340 aa), FASTA scores: opt: 210, E(): 2.5 e-09, (42.9% identity in 105 aa overlap).; hypothetical protein	1699866..1700228	Mycobacterium tuberculosis H37Rv	3205096
NP_216025.1	CDS	Rv1509	NC_000962.2	1700212	1701093	D	Rv1509, (MTCY277.31), len: 298 aa. Hypothetical unknown protein.; hypothetical protein	1700212..1701093	Mycobacterium tuberculosis H37Rv	886475
NP_216026.1	CDS	Rv1510	NC_000962.2	1701295	1702593	D	Rv1510, (MTCY277.32), len: 432 aa. Probable membrane protein. Highly similar to Rv3630|MTCY15C10.22 (431 aa), FASTA scores: E(): 0, (70.8% identity in 424 aa overlap).; hypothetical protein	1701295..1702593	Mycobacterium tuberculosis H37Rv	886466
NP_216027.1	CDS	gmdA	NC_000962.2	1703074	1704096	D	Rv1511, (MTCY277.33), len: 340 aa. Probable gmdA, GDP-D-mannose dehydratase (EC 4.2.1.47), equivalent to AF125999|AF125999_13 Mycobacterium avium enzyme (343 aa), FASTA scores: opt: 2085, E(): 0, (89.1% identity in 338 aa overlap); similar to G755218 PSEUDOMONAS AERUGINOSA GDP-D-MANNOSE DEHYDRATASE (GCA) (323 aa), FASTA scores: opt: 1073, E(): 0, (51.9% identity in 320 aa overlap); and to S74433 GDP-D-mannose dehydratase rfbD - Syn (362 aa), FASTA scores: opt: 1405, E(): 0, (63.9% identity in 327 aa overlap).; GDP-D-mannose dehydratase gmdA (GDP-mannose 4,6 dehydratase) (GMD)	1703074..1704096	Mycobacterium tuberculosis H37Rv	886529
NP_216028.1	CDS	epiA	NC_000962.2	1704093	1705061	D	Rv1512, (MTCY277.34), len: 322 aa. Probable epiA, NUCLEOTIDE SUGAR EPIMERASE, equivalent to AJ223832|MAS223832_4 from Mycobacterium avium silvaticum (339 aa), FASTA scores: opt: 1821, E(): 0, (84.6% identity in 318 aa overlap); and similar to WCAG_ECOLI|P32055 colanic acid biosynthesis protein wcaG (321 aa), FASTA scores: opt: 835, E(): 0, (53.5% identity in 316 aa overlap).; nucleotide-sugar epimerase epiA	1704093..1705061	Mycobacterium tuberculosis H37Rv	886461
NP_216029.1	CDS	Rv1513	NC_000962.2	1705058	1705789	D	Rv1513, (MTCY277.35), len: 243 aa. Conserved hypothetical protein, similar to hypothetical proteins from several organisms e.g. AJ223833|MAP223833_3 from Mycobacterium avium paratuberculosis (240 aa), FASTA scores: opt: 1053 E(): 0, (66.3% identity in 243 aa overlap); P74191|SLL1173 from Synechocystis (244 aa), FASTA scores: opt: 276, E(): 1.1e-07, (32.2 % identity in 202 aa overlap). Also highly similar to P95136|Q50460|MTCY349.33c|Rv2956 from Mycobacterium tuberculosis (243 aa), (70.0% identity in 237 aa overlap).; hypothetical protein	1705058..1705789	Mycobacterium tuberculosis H37Rv	886464
NP_216030.1	CDS	Rv1514c	NC_000962.2	1705807	1706595	R	Rv1514c, (MTCY277.36c), len: 262 aa. Conserved hypothetical protein. Similar to other hypothetical proteins, and to WCAE_ECOLI|P71239 putative colanic acid biosynthesis glycosyl transferase (248 aa), FASTA scores: opt: 231, E(): 4.1e-08, (33.3% identity in 210 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical glycosyltransferase, Rv2957.; hypothetical protein	complement(1705807..1706595)	Mycobacterium tuberculosis H37Rv	886457
NP_216031.1	CDS	Rv1515c	NC_000962.2	1706630	1707526	R	Rv1515c, (MTCY277.37c), len: 298 aa. Conserved hypothetical protein, similar to P71805|MTCY02B12.11C|Rv1377c Hypothetical protein from Mycobacterium tuberculosis, FASTA scores: E(): 1.3e-05, (25.4% identity in 134 aa overlap).; hypothetical protein	complement(1706630..1707526)	Mycobacterium tuberculosis H37Rv	886459
NP_216032.2	CDS	Rv1516c	NC_000962.2	1707529	1708539	R	Rv1516c, (MTCY277.38c), len: 336 aa. Probable sugar transferase (EC 2.-.-.-), similar to AB010970|AB010970_6 glycosyltransferase from Streptococcus mutans (465 aa), FASTA scores: opt: 388, E(): 4.1e-18, (32.7% identity in 214 aa overlap), slight similarity to SPSA_BACSU|P39621 spore coat polysaccharide biosynthesis (256 aa), fasta scores: opt: 185, E(): 6.5e-05, (26.2% identity in 187 aa overlap), strong similarity to Rv1520|MTCY19G5.08c probable sugar transferase from Mycobacterium tuberculosis (63.5% identity in 318 aa overlap).; sugar transferase	complement(1707529..1708539)	Mycobacterium tuberculosis H37Rv	886455
NP_216033.1	CDS	Rv1517	NC_000962.2	1708871	1709635	D	Rv1517, (MTCY277.39), len: 254 aa. Conserved hypothetical transmembrane protein, similar to G466802|LEPB1170_F2_64 from Mycobacterium leprae (230 aa), FASTA scores: opt: 282, E(): 2.2e-11, (34.1% identity in 255 aa overlap). Also similar to Mycobacterium tuberculosis Rv3821|MTCY409.09c (237 aa) (36.3% identity in 256 aa overlap); and Rv3481c.; hypothetical protein	1708871..1709635	Mycobacterium tuberculosis H37Rv	886467
NP_216034.1	CDS	Rv1518	NC_000962.2	1709644	1710603	D	Rv1518, (MTCY277.40, MTCY19G5.11c), len: 319 aa. Conserved hypothetical protein, possibly glycosyl transferase involved in exopolysaccharide synthesis, similar to several hypothetical proteins and glycosyl transferases from diverse organisms e.g. P73996|D90911 from SYNECHO CYSTIS sp. (309 aa), Fasta scores: opt: 300, E(): 1.8e-13, (29.5% identity in 241 aa overlap).; hypothetical protein	1709644..1710603	Mycobacterium tuberculosis H37Rv	886451
NP_216035.1	CDS	Rv1519	NC_000962.2	1710733	1711002	D	Rv1519, (MTCY19G5.09c), len: 89 aa. Conserved hypothetical protein, high similarity to C-terminus of Q50723|MTCY78.26|Rv3402c (412 aa) (58.1% identity in 74 aa overlap).; hypothetical protein	1710733..1711002	Mycobacterium tuberculosis H37Rv	886453
NP_216036.1	CDS	Rv1520	NC_000962.2	1711028	1712068	D	Rv1520, (MTCY19G5.08c), len: 346 aa. Probable sugar transferase (EC 2.-.-.-), similar to several e.g. AB010970|AB010970_6 Streptococcus mutans glycosyltransferase (465 aa), FASTA scores: opt: 381, E(): 1.2e-18, (31.7% identity in 240 aa overlap); O34234|Y07786 SUGAR TRANSFERASE from Vibrio cholerae (337 aa), FASTA scores: opt: 214, E(): 8.4e-05, (25.9% identity in 212 aa overlap). Also strongly similar to Mycobacterium tuberculosis probable sugar transferase Rv1516c.; sugar transferase	1711028..1712068	Mycobacterium tuberculosis H37Rv	886447
NP_216037.1	CDS	fadD25	NC_000962.2	1712302	1714053	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	1712302..1714053	Mycobacterium tuberculosis H37Rv	886448
NP_216038.1	CDS	mmpL12	NC_000962.2	1714172	1717612	R	Rv1522c, (MTCY19G5.06), len: 1146 aa. Probable mmpL12, conserved transmembrane transport protein (see Tekaia et al., 1999), member of RND superfamily. Strong similarity to many Mycobacterial membrane proteins e.g. Q49619|G466786 putative transport protein B1170_C1_181 from Mycobacterium leprae (1008 aa), FASTA scores: opt: 2418, E(): 0, (51.0% identity in 1006 aa overlap); etc. Also highly similar to MmpL8|MTCY48.08c|Rv3823c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis, FASTA score: (34.3% identity in 376 aa overlap); and some similarity to MmpL10|MTCY20G9|Rv1183 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN, FASTA score: (27.2% identity in 1011 aa overlap). BELONGS TO THE MMPL FAMILY.; transmembrane transport protein MmpL12	complement(1714172..1717612)	Mycobacterium tuberculosis H37Rv	886445
NP_216039.1	CDS	Rv1523	NC_000962.2	1717653	1718696	D	Rv1523, (MTCY19G5.05c), len: 347 aa (start uncertain). Probable methyltransferase (EC 2.1.1.-), similar to G560513|U0002O Mycobacterium leprae (270 aa), FASTA scores: opt: 965, E(): 0, (60.3% identity in 247 aa overlap). Also similar to many e.g. Q54303|X86780 METHYLTRANSFERASE RAPM from Streptomyces hygroscopicus (317 aa), FASTA scores: opt: 323, E(): 1e-15, (41.2% identity in 136 aa overlap). And similar to M. tuberculosis hypothetical proteins Rv2952, Rv1405c, Rv1403c, Rv0839.; methyltransferase	1717653..1718696	Mycobacterium tuberculosis H37Rv	886489
NP_216040.1	CDS	Rv1524	NC_000962.2	1718726	1719970	D	Rv1524, (MTCY19G5.04c), len: 414 aa. Probable glycosyltransferase (EC 2.4.1.-), similar to many e.g. P96559|U84349 GLYCOSYLTRANSFERASE GTFB from Amycolatopsis orientalis (407 aa), FASTA scores: opt: 363, E(): 6.2e-23, (28.8% identity in 430 aa overlap); also high similarity to Rv1526c|MTCY19G5.02 Mycobacterium tuberculosis hypothetical protein (58.7% identity in 416 aa overlap); and AF143772|AF143772_15 glycosyltransferase gtfB from Mycobacterium avium strain 215 (418 aa), FASTA scores: opt: 1801, E(): 0, (65.2% identity in 417 aa overlap).; glycosyltransferase	1718726..1719970	Mycobacterium tuberculosis H37Rv	885814
NP_216041.1	CDS	wbbL2	NC_000962.2	1720017	1720802	D	Rv1525, (MT1576, MTCY19G5.03c), len: 261 aa. Possible wbbL2, rhamnosyl transferase (EC 2.-.-.-) (see citation below), showing weak similarity to several rhamnosyl transferases. Similar to AF105060|AF105060_1 Riftia pachyptila endosymbiont (746 aa), FASTA scores: opt: 183, E(): 0.00013, (35.2% identity in 105 aa overlap).; rhamnosyl transferase WbbL2	1720017..1720802	Mycobacterium tuberculosis H37Rv	886470
NP_216042.1	CDS	Rv1526c	NC_000962.2	1720780	1722060	R	Rv1526c, (MTCY19G5.02), len: 426 aa. Probable glycosyltransferase (EC 2.4.1.-), highly similar to G467196 Protein L518_C2_147 from Mycobacterium leprae (421 aa), FASTA scores, opt: 1497, E(): 0, (55.0% identity in 424 aa overlap); similar to G452504 rhamnosyltransferase (24.7% identity in 433 aa overlap); and P96565|U84350 GLYCOSYLTRANSFERASE GTFE from Amycolatopsis orientalis (408 aa), E(): 3.4e-24, (28.4% identity in 429 aa overlap), also high similarity to Rv1524|MTCY19G5.04c (58.7 % identity in 416 aa overlap).; glycosyltransferase	complement(1720780..1722060)	Mycobacterium tuberculosis H37Rv	886434
NP_216043.1	CDS	pks5	NC_000962.2	1722083	1728409	R	Rv1527c, (MTV045.01c-MTCY19G5.01), len: 2108 aa. Probable pks5, polyketide synthase, highly similar to many e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from Mycobacterium bovis (2110 aa), FASTA scores: opt: 6270, E(): 0, (63.6% identity in 2126 aa overlap).; polyketide synthase pks5	complement(1722083..1728409)	Mycobacterium tuberculosis H37Rv	886442
NP_216044.1	CDS	papA4	NC_000962.2	1728953	1729450	R	Rv1528c, (MTV045.02), len: 165 aa. Probable papA4, conserved polyketide synthase (PKS) associated protein; shows some similarity to C-terminal part of hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. Z97188|MTCY409_10 Mycobacterium tuberculosis cosmid (468) (37.9% identity in 66 aa overlap); or U00010_11 Mycobacterium leprae cosmid B1170 (35.7% identity in 84 aa overlap). Also similar to Mycobacterium tuberculosis PKS-associated proteins Rv1182, Rv3824c, Rv3820c.; polyketide synthase associated protein	complement(1728953..1729450)	Mycobacterium tuberculosis H37Rv	886028
NP_216045.1	CDS	fadD24	NC_000962.2	1729502	1731256	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	1729502..1731256	Mycobacterium tuberculosis H37Rv	886432
NP_216046.1	CDS	adh	NC_000962.2	1731373	1732476	D	Rv1530, (MTV045.04), len: 367 aa. Probable adh, alcohol dehydrogenase (EC 1.1.1.1), zinc-dependent, similar to many e.g. AE0009|AE000958_23 Archaeoglobus fulgidus section 1 (402 aa), FASTA scores: opt: 423, E(): 1.8e-19, (31.7% identity in 341 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. TBparse score is 0.919.; alcohol dehydrogenase adh	1731373..1732476	Mycobacterium tuberculosis H37Rv	886426
NP_216047.1	CDS	Rv1531	NC_000962.2	1732473	1733039	D	Rv1531, (MTV045.05), len: 188 aa. Conserved hypothetical protein, similar to Rv0464c|MTV038.08c (190 aa), FASTA scores: E(): 4.8e-10, (30.9% identity in 175 aa overlap).; hypothetical protein	1732473..1733039	Mycobacterium tuberculosis H37Rv	886437
NP_216048.1	CDS	Rv1532c	NC_000962.2	1733116	1733550	R	Rv1532c, (MTCY07A7A.01c), len: 144 aa. Conserved hypothetical protein, similar to P20378|YPHR_HALHA Hypothetical 15.6 kDa protein from Halobacterium halobium (151 aa), FASTA scores: opt: 152, E():4.5e-05, (30.1% identity in 103 aa overlap).; hypothetical protein	complement(1733116..1733550)	Mycobacterium tuberculosis H37Rv	886422
NP_216049.1	CDS	Rv1533	NC_000962.2	1733610	1734737	D	Rv1533, (MTCY07A7A.02), len: 375 aa. Conserved hypothetical protein. Similar to 2NPD_NEUCR|Q01284 2-nitropropane dioxygenase precursor (378 aa), fasta scores: opt: 279, E(): 9.1e-11, (31.3% identity in 256 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1894c, Rv0021c, Rv3553, Rv2781c.; hypothetical protein	1733610..1734737	Mycobacterium tuberculosis H37Rv	886424
NP_216050.1	CDS	Rv1534	NC_000962.2	1734734	1735411	D	Rv1534, (MTCY07A7A.03), len: 225 aa. Probable transcriptional regulator, similar to YCDC_ECOLI|P75899 hypothetical transcriptional regulator from Escherichia coli (212 aa), FASTA scores: opt: 166, E(): 9.8e-05, (24.2% identity in 219 aa overlap). Contains PS01081 Bacterial regulatory proteins, tetR family signature and helix turn helix motif (aa 41-62).; transcriptional regulator	1734734..1735411	Mycobacterium tuberculosis H37Rv	886420
NP_216051.1	CDS	Rv1535	NC_000962.2	1735976	1736212	D	Rv1535, (MTCY07A7A.04), len: 78 aa. Hypothetical unknown protein.; hypothetical protein	1735976..1736212	Mycobacterium tuberculosis H37Rv	886429
NP_216052.1	CDS	ileS	NC_000962.2	1736519	1739644	D	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase	1736519..1739644	Mycobacterium tuberculosis H37Rv	886412
NP_216053.2	CDS	dinX	NC_000962.2	1739841	1741247	D	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV	1739841..1741247	Mycobacterium tuberculosis H37Rv	886414
NP_216054.1	CDS	ansA	NC_000962.2	1741212	1742192	R	Rv1538c, (MTCY48.27), len: 326 aa. Probable ansA, L-aparaginase, most similar to ASPG_BACLI|P30363 L-asparaginase (322 aa), FASTA scores: opt: 417, E(): 8.8e-19, (30.9% identity in 314 aa overlap). Contains PS00917 Asparaginase / glutaminase active site signature 2.; L-aparaginase ansA	complement(1741212..1742192)	Mycobacterium tuberculosis H37Rv	886410
NP_216055.1	CDS	lspA	NC_000962.2	1742244	1742852	D	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase	1742244..1742852	Mycobacterium tuberculosis H37Rv	886408
NP_216056.1	CDS	Rv1540	NC_000962.2	1742845	1743771	D	Rv1540, (MTCY48.25c), len: 308 aa. Member of the yabO/yceC/yfiI family of hypothetical proteins, similar to P44445|YFII_HAEIN hypothetical protein HI0176 from Haemophilus influenzae (324 aa), FASTA scores: opt: 437, E(): 1.2e-22, (33.2% identity in 322 aa overlap). Equivalent to AL049478|MLCL458_13 hypothetical protein from Mycobacterium leprae (308 aa), (89.3% identity in 307 aa overlap). Contains PS01129 hypothetical yabO/yceC/yfiI family signature.; hypothetical protein	1742845..1743771	Mycobacterium tuberculosis H37Rv	886404
NP_216057.1	CDS	lprI	NC_000962.2	1743778	1744371	R	Rv1541c, (MTCY48.24), len: 197 aa. Possible lipoprotein lprI, contains appropriately positioned prokaryotic membrane lipoprotein lipid attachment site (PS0013).; lipoprotein LprI	complement(1743778..1744371)	Mycobacterium tuberculosis H37Rv	886406
NP_216058.1	CDS	glbN	NC_000962.2	1744426	1744836	R	Rv1542c, (MTCY48.23), len: 136 aa. Probable glbN, hemoglobin. Belongs to the protozoan/cyanobacterial globin family. Similar to myoglobins e.g. GLB_PARCA|P15160 myoglobin (hemoglobin) paramecium (116 aa), FASTA scores, opt: 284, E(): 2.1e -13, (35.7% identity in 115 aa overlap). Similar to Mycobacterium tuberculosis hypothetical globin, Rv2470.; hemoglobin glbN	complement(1744426..1744836)	Mycobacterium tuberculosis H37Rv	886402
NP_216059.1	CDS	Rv1543	NC_000962.2	1745064	1746089	D	Rv1543, (MTCY48.22c), len: 341 aa. Possible fatty-acyl CoA reductase (EC 1.2.1.-), highly similar to P94129|U77680 FATTY ACYL-CoA REDUCTASE ACR1 from Acinetobacter calcoaceticus (295 aa), FASTA scores: opt: 899, E(): 0, (48.5% identity in 293 aa overlap). Also highly similar to acrA1|Rv3391|MTV004.49|NP_217908.1|NC_000962 fatty acyl-CoA reductase from Mycobacterium tuberculosis (650 aa). Also highly similar to many oxidoreductases short-chain family.; fatty acyl-CoA reductase	1745064..1746089	Mycobacterium tuberculosis H37Rv	886400
NP_216060.1	CDS	Rv1544	NC_000962.2	1746094	1746897	D	Rv1544, (MTCY48.21), len: 267 aa. Possible ketoacyl reductase (EC 1.3.1.-), highly similar to Z97179|MLCL383_26 putative oxidoreductase from Mycobacterium leprae (268 aa), FASTA score: (43.0% identity in 270 aa overlap). Also highly similar to others e.g. T29125 ketoacyl reductase homolog from Streptomyces coelicolor (276 aa); NP_470957.1|NC_003212 protein similar to ketoacyl reductases from Listeria innocua (253 aa); HETN_ANASP|P37694 ketoacyl reductase from Anabaena sp. strain PCC 7120 (287 aa), FASTA scores: opt: 379, E(): 7.5e-18, (31.6% identity in 250 aa overlap); etc. And highly similar to many oxidoreductases short-chain family. Also highly similar to Rv2509 from Mycobacterium tuberculosis (268 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; ketoacyl reductase	1746094..1746897	Mycobacterium tuberculosis H37Rv	886417
NP_216061.1	CDS	Rv1545	NC_000962.2	1746919	1747146	D	Rv1545, (MTCY48.20), len: 75 aa. Hypothetical unknown protein.; hypothetical protein	1746919..1747146	Mycobacterium tuberculosis H37Rv	886398
NP_216062.1	CDS	Rv1546	NC_000962.2	1747195	1747626	D	Rv1546, (MTCY48.19c), len: 143 aa. Conserved hypothetical protein, similar to O05902|Rv0910|MTCY21C12.04 Hypothetical protein from Mycobacterium tuberculosis (144 aa), FASTA scores: E(): 5e-30, (37.3% identity in 142 aa overlap).; hypothetical protein	1747195..1747626	Mycobacterium tuberculosis H37Rv	886394
NP_216063.1	CDS	dnaE	NC_000962.2	1747694	1751248	D	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha	1747694..1751248	Mycobacterium tuberculosis H37Rv	886392
YP_177817.1	CDS	PPE21	NC_000962.2	1751297	1753333	R	Rv1548c, (MTCY48.17), len: 678 aa. Member of the Mycobacterium tuberculosis PPE family, similar to several e.g. YHS6_MYCTU|P42611 hypothetical 50.6 kDa protein in hsp65 3' region (517 aa), FASTA scores: opt:1142, E(): 0, (40.6% identity in 616 aa overlap); also similar to MTCY31.06c (54.9% identity in 381 aa overlap).; PPE family protein	complement(1751297..1753333)	Mycobacterium tuberculosis H37Rv	886384
YP_177818.1	CDS	fadD11.1	NC_000962.2	1753510	1754037	D	Rv1549, (MTCY48.16c), len: 175 aa. Possible fadD11.1, fatty-acid-CoA synthetase (EC 6.2.1.-), similar to the N-terminus of many fatty-acid CoA synthetases e.g. NP_147860.1|NC_000854 long-chain-fatty-acid--CoA ligase from Aeropyrum pernix (651 aa); P31685|4CL2_SOLTU 4-coumarate--CoA ligase 2 (EC 6.2.1.12) from Solanum tuberosum (Potato) (545 aa), FASTA scores: opt: 168, E(): 4.4e-06, (30.4% identity in 112 aa overlap); etc. Possible frameshift with respect to next ORF Rv1550|MTCY48.15c but we can find no sequence error to account for this. Note that previously known as fadD11'.; fadD11'; fatty-acid-CoA ligase	1753510..1754037	Mycobacterium tuberculosis H37Rv	886386
NP_216066.1	CDS	fadD11	NC_000962.2	1753716	1755431	D	Rv1550, (MTCY48.15c), len: 571 aa. Probable fadD11, fatty-acid-CoA synthetase (EC 6.2.1.-), similar, except in N-terminus, to many e.g. SC6A5.39|T35430 probable long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) from Streptomyces coelicolor (612 aa); NP_301672.1|NC_002677 putative long-chain-fatty-acid-CoA ligase from Mycobacterium leprae (600 aa); P44446|LCFH_HAEIN putative long-chain-fatty-acid-CoA ligase from Haemophilus influenzae (607 aa), FASTA scores: opt: 762, E(): 2.3e-38, (34.4% identity in 436 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Possible frameshift with respect to previous ORF Rv1549|MTCY48.16c but we can find no sequence error to account for this.; fatty-acid-CoA ligase	1753716..1755431	Mycobacterium tuberculosis H37Rv	886380
NP_216067.1	CDS	plsB1	NC_000962.2	1755445	1757310	D	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase	1755445..1757310	Mycobacterium tuberculosis H37Rv	886382
NP_216068.1	CDS	frdA	NC_000962.2	1757681	1759432	D	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit	1757681..1759432	Mycobacterium tuberculosis H37Rv	886376
NP_216069.1	CDS	frdB	NC_000962.2	1759435	1760178	D	Rv1553, (MTCY48.12c), len: 247 aa. Probable frdB, fumarate reductase, iron-sulfur subunit (EC 1.3.99.1), highly similar to others e.g. P00364|FRDB_ECOLI fumarate reductase iron-sulfur protein from Escherichia coli strain K12 (243 aa), FASTA scores: opt: 846, E(): 0, (50.0% identity in 242 aa overlap); P20921|FRDB_PROVU FUMARATE REDUCTASE IRON-SULFUR PROTEIN from Proteus vulgaris (245 aa); G64097 fumarate reductase (EC 1.3.99.1) iron-sulfur protein from Haemophilus influenzae (276 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. NOTE THAT FUMARATE REDUCTASE FORMS PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and Rv1555|frdD).; fumarate reductase iron-sulfur subunit FrdB	1759435..1760178	Mycobacterium tuberculosis H37Rv	886378
NP_216070.1	CDS	frdC	NC_000962.2	1760175	1760555	D	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C	1760175..1760555	Mycobacterium tuberculosis H37Rv	886371
NP_216071.1	CDS	frdD	NC_000962.2	1760552	1760929	D	in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D	1760552..1760929	Mycobacterium tuberculosis H37Rv	886389
NP_216072.1	CDS	Rv1556	NC_000962.2	1760997	1761605	D	Rv1556, (MTCY48.09c), len: 202 aa. Possible regulatory protein, similar to X86780|SHGCPIR2|g987088 orfY, regulator of antibiotic transport complexes from Streptomyces hygroscopicus (204 aa), FASTA score: opt: 251, E(): 1.7e-10, (33.8% identity in 201 aa overlap) and others.; regulatory protein	1760997..1761605	Mycobacterium tuberculosis H37Rv	886367
NP_216073.1	CDS	mmpL6	NC_000962.2	1761744	1762937	D	Rv1557, (MTCY48.08c), len: 397 aa. Probable mmpL6, conserved transmembrane transport protein (see citations below). Member of RND superfamily, with strong similarity to C-terminal part of members of large Mycobacterial membrane protein family belonging to RND superfamily including: mmpL1, mmpL2, mmpL3, etc. Probably truncated (see Brosch et al., 2002). BELONGS TO THE MMPL FAMILY.; transmembrane transport protein MmpL6	1761744..1762937	Mycobacterium tuberculosis H37Rv	886033
NP_216074.1	CDS	Rv1558	NC_000962.2	1762947	1763393	D	Rv1558, (MTCY48.07c), len: 148 aa. Conserved hypothetical protein, similar to other Mycobacterial tuberculosis proteins e.g. P71854|MTCY03C7.09c|Rv3547 (151 aa), FASTA scores opt: 330, E(): 9.1e-17, (39.7% identity in 151 aa overlap); also Q11057|Rv1261c (149 aa), and O53328|Rv3178 (119 aa). Similar also to AF072709|AF072709_5 Hypothetical protein with a new amplifiable element AUD4 from Streptomyces lividans (149 aa), FASTA scores: opt: 695, E(): 0, (69.1% identity in 149 aa overlap).; hypothetical protein	1762947..1763393	Mycobacterium tuberculosis H37Rv	886363
NP_216075.1	CDS	ilvA	NC_000962.2	1763428	1764717	D	catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase	1763428..1764717	Mycobacterium tuberculosis H37Rv	886365
NP_216076.1	CDS	Rv1560	NC_000962.2	1764755	1764973	D	Rv1560, (MTCY48.05c), len: 72 aa. Conserved hypothetical protein, part of a Mycobacterial tuberculosis family of proteins e.g. Q10848|Rv2009|MTCY39.08c (80 aa), FASTA score: (54.4% identity in 68 aa overlap); Q10799|Rv2871|MTCY274.02 (85 aa); O50456|Rv1241|MTV006.13 (86 aa), O06243|Rv2132|MTCY270.36C (76 aa); etc.; hypothetical protein	1764755..1764973	Mycobacterium tuberculosis H37Rv	886359
NP_216077.1	CDS	Rv1561	NC_000962.2	1764979	1765383	D	Rv1561, (MTCY48.04c), len: 134 aa. Conserved hypothetical protein, similar to others from Mycobacterium tuberculosis e.g. Q10847|Rv2010|MTCY39.07c (132 aa), FASTA scores: (37.0% identity in 127 aa overlap); and O06566|Rv1114|MTCY22G8.03 (124 aa).; hypothetical protein	1764979..1765383	Mycobacterium tuberculosis H37Rv	886361
YP_177819.1	CDS	treZ	NC_000962.2	1765400	1767142	R	Rv1562c, (MTCY48.03), len: 580 aa. treZ (previously called glgZ), Maltooligosyltrehalose trehalohydrolase, confirmed biochemically (see citation below). Similar to Q44316|D63343 TREZ MALTOOLIGOSYL TREHALOSE TREHALOHYDROLASE from ARTHROBACTER SP (598 aa), FASTA scores: opt: 2071, E(): 0, (52.2% identity in 582 aa overlap); also similar to 1,4-alpha-glucan branching enzymes e.g. GLGB_BACST|P30538 (639 aa), FASTA scores: opt: 313, E(): 3.8e-13, (27.5% identity in 462 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv1326c|glgB, and Rv1563c treY (previously glgY).; glgZ; maltooligosyltrehalose trehalohydrolase TreZ	complement(1765400..1767142)	Mycobacterium tuberculosis H37Rv	886355
YP_177820.1	CDS	treY	NC_000962.2	1767135	1769432	R	Rv1563c, (MTCY48.02), len: 765 aa. treY (previously called glgY), maltooligosyl trehalose synthase, confirmed biochemically (see citation below). Strong similarity to Q44315|63343 TREY MALTOOLIGOSYL TREHALOSE SYNTHASE from ARTHROBACTER SP (775 aa), fasta scores: opt: 1953, E(): 0; (46.0% identity in 789 aa overlap). Some similarity to alpha-amylases and to MTCY48.03 (30.2% identity in 215 aa overlap). May catalyse conversion of maltodextrins to maltooligosyl trehaloses. Also similar to Mycobacterium tuberculosis glgB (Rv1326c), treZ (Rv1562c).; glgY; maltooligosyltrehalose synthase TreY	complement(1767135..1769432)	Mycobacterium tuberculosis H37Rv	886357
YP_177821.1	CDS	treX	NC_000962.2	1769436	1771601	R	Rv1564c, (MTCY48.01), len: 721 aa. Probable treX (previously called glgX), Maltooligosyltrehalose synthase. Strong similarity to D83245|g1890053 treX, glycogen debranching enzyme (glgX) from Sulfolobus acidocaldarius (713 aa), FASTA score: opt: 2396, E(): 0, (48.4% identity in 709 aa overlap); similar to GLGX_HAEIN|P45178 glycogen operon protein glgx (659 aa), FASTA scores: opt: 1512, E(): 0, (42.3% identity in 645 aa overlap).; glgX; maltooligosyltrehalose synthase TreX	complement(1769436..1771601)	Mycobacterium tuberculosis H37Rv	886353
NP_216081.1	CDS	Rv1565c	NC_000962.2	1771640	1773829	R	Rv1565c, (MTCY336.38), len: 729 aa. Conserved hypothetical membrane protein, some similarity to O05402 HYPOTHETICAL 72.2 kDa PROTEIN from Bacillus subtilis (634 aa), FASTA results: opt: 384, E(): 4.8e-17, (29.1% identity in 378 aa overlap); and to Y392_HAEIN|P43993 hypothetical protein hi0392 from H. influenzae (245 aa), FASTA results: opt: 265, E(): 5.5e-10, (28.3% identity in 247 aa overlap). C-terminal half equivalent to AL049478|MLCL458_19 (274 aa) (78.5% identity in 274 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0111, Rv0228, Rv1254, Rv0517. N-terminal half hydrophobic. TBparse score is 0.930.; hypothetical protein	complement(1771640..1773829)	Mycobacterium tuberculosis H37Rv	886351
NP_216082.1	CDS	Rv1566c	NC_000962.2	1773928	1774620	R	Rv1566c, (MTCY336.37), len: 230 aa. Possible inv protein, probably exported as has QQAPV repeats at C-terminus. Similar to Q49634 inv protein from Mycobacterium leprae (246 aa), FASTA scores: opt: 957, E(): 0, (70.0% identity in 207 aa overlap); also to putative invasins 1,2 (O07390, O07391) from Mycobacterium avium. Slightly similar to C-terminus of P60_LISMO|P21171 Listeria invasion-associated protein p60 precursor. Also similar to Mycobacterium tuberculosis p60 homologues Rv1477, Rv1478, Rv0024, Rv2190c. TBparse score is 0.890.; inv protein	complement(1773928..1774620)	Mycobacterium tuberculosis H37Rv	886347
NP_216083.1	CDS	Rv1567c	NC_000962.2	1774860	1775144	R	Rv1567c, (MTCY336.36), len: 94 aa. Probable membrane protein. TBparse score is 0.915.; hypothetical protein	complement(1774860..1775144)	Mycobacterium tuberculosis H37Rv	886349
NP_216084.1	CDS	bioA	NC_000962.2	1775392	1776705	D	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase	1775392..1776705	Mycobacterium tuberculosis H37Rv	886343
YP_177822.1	CDS	bioF1	NC_000962.2	1776702	1777862	D	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase	1776702..1777862	Mycobacterium tuberculosis H37Rv	886345
NP_216086.1	CDS	bioD	NC_000962.2	1777859	1778539	D	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase	1777859..1778539	Mycobacterium tuberculosis H37Rv	886338
NP_216087.1	CDS	Rv1571	NC_000962.2	1778539	1779048	D	Rv1571, (MTCY336.32c), len: 169 aa. Conserved hypothetical protein, similar at N-terminal region to Q49625|LEPB1170_C3_227 hypothetical protein from Mycobacterium leprae (104 aa), FASTA results: opt: 473, E(): 3.9e-24, (74.5% identity in 102 aa overlap). Identical to O06619|AF041819|AF041819_6 Mycobacterium bovis BCG (169 aa). TBparse score is 0.871.; hypothetical protein	1778539..1779048	Mycobacterium tuberculosis H37Rv	886341
NP_216088.2	CDS	Rv1572c	NC_000962.2	1779194	1779298	R	Rv1572c, (MTCY336.31B), len: 34 aa. Partial ORF, part of REP13E12 repeat element; 3' end of Rv1587c (MTCY336.17) after phage-like element (see citation below). Similar to C-terminal ends of other REP13E12 repeat elements e.g. Rv1148, Rv1945, Rv3467, etc. Length extended since first submission (+7 aa).; hypothetical protein	complement(1779194..1779298)	Mycobacterium tuberculosis H37Rv	886333
NP_216089.1	CDS	Rv1573	NC_000962.2	1779314	1779724	D	Rv1573, (MTCY336.31c), len: 136 aa. Probable phiRv1 phage protein (see citation below). TBparse score is 0.872.; phiRV1 phage protein	1779314..1779724	Mycobacterium tuberculosis H37Rv	886337
NP_216090.1	CDS	Rv1574	NC_000962.2	1779930	1780241	D	Rv1574, (MTCY336.30), len: 103 aa. Probable phiRV1 phage related protein (see citation below); some similarity to N-terminus of Rv1575|MTCY441.17 Probable phiRV1 phage protein (166 aa), E(): 1.5e-06; and Rv2647|MTCY336.29c Probable phiRV2 phage protein, E(): 3.5e-05. Helix turn helix motif present at aa 14-35 (+3.61 SD).; phiRV1 phage related protein	1779930..1780241	Mycobacterium tuberculosis H37Rv	886331
NP_216091.2	CDS	Rv1575	NC_000962.2	1780199	1780699	D	Rv1575, (MTCY336.29c), len: 166 aa. Probable phiRV1 phage protein (see citation below), showing similarity in N-terminal part to Rv1574|MTCY336.30c Probable phiRV1 phage protein (103 aa), FASTA score: opt: 375, E(): 3.8e-16, (60.2% identity in 103 aa overlap); and Rv2647 Probable phiRV2 phage protein. Start changed since first submission (+49 aa).; phiRV1 phage protein	1780199..1780699	Mycobacterium tuberculosis H37Rv	886335
NP_216092.1	CDS	Rv1576c	NC_000962.2	1780643	1782064	R	Rv1576c, (MTCY336.28), len: 473 aa. Probable phiRV1 phage protein (capsid subunit) (see citation below). Highly similar to hypothetical Mycobacterium tuberculosis protein Rv2650c|MTCY441.19 phiRV2 phage related protein, FASTA scores: opt: 2782, E(): 0, (89.1% identity in 468 aa overlap). TBparse score is 0.909.; phiRV1 phage protein	complement(1780643..1782064)	Mycobacterium tuberculosis H37Rv	886327
NP_216093.1	CDS	Rv1577c	NC_000962.2	1782072	1782584	R	Rv1577c, (MTCY336.27), len: 170 aa. Probable phiRv1 phage protein (prohead protease) (see citation below). Highly similar to hypothetical protein Rv2651c|MTCY441.20c phiRV2 prohead protease, FASTA scores: E(): 0, (89.3% identity in 169 aa overlap). Some similarity to VP4_BPHK7|P49860 putative bacteriophage HK97 prohead protease (gp4) (225 aa), FASTA results: opt: 176, E(): 1.3e-05, (27.3% identity in 165 aa overlap). TBparse score is 0.912.; phiRv1 phage protein	complement(1782072..1782584)	Mycobacterium tuberculosis H37Rv	886329
NP_216094.1	CDS	Rv1578c	NC_000962.2	1782758	1783228	R	Rv1578c, (MTCY336.26), len: 156 aa. Probable phiRv1 phage protein (terminase) (see citation below), highly similar to Rv2652c|MTCY441.21c phiRV2 phage protein from Mycobacterium tuberculosis, FASTA scores: E(): 4.8e-22, (48.1% identity in 156 aa overlap). Also similar to X65555|ARP3COS_1 hypothetical protein (cos site) - actinophage RP3 (210 aa), FASTA scores: opt: 373, E(): 6.5e-17, (50.0% identity in 114 aa overlap). Contains MIP family signature (PS00221). TBparse score is 0.902.; phiRv1 phage protein	complement(1782758..1783228)	Mycobacterium tuberculosis H37Rv	886322
NP_216095.1	CDS	Rv1579c	NC_000962.2	1783309	1783623	R	Rv1579c, (MTCY336.25), len: 104 aa. Probable phiRv1 phage protein (see citation below). TBparse score is 0.921.; phiRv1 phage protein	complement(1783309..1783623)	Mycobacterium tuberculosis H37Rv	886369
NP_216096.1	CDS	Rv1580c	NC_000962.2	1783620	1783892	R	Rv1580c, (MTCY336.24), len: 90 aa. Probable phiRv1 phage protein (see citation below). TBparse score is 0.878.; phiRv1 phage protein	complement(1783620..1783892)	Mycobacterium tuberculosis H37Rv	886313
NP_216097.1	CDS	Rv1581c	NC_000962.2	1783906	1784301	R	Rv1581c, (MTCY336.23), len: 131 aa. Probable phiRv1 phage protein (see citation below). TBparse score is 0.928.; phiRv1 phage protein	complement(1783906..1784301)	Mycobacterium tuberculosis H37Rv	886318
NP_216098.1	CDS	Rv1582c	NC_000962.2	1784497	1785912	R	Rv1582c, (MTCY336.22), len: 471 aa. Probable phiRv1 phage protein (see citation below). N-terminus is similar to C-terminus of Q38030 ORF9 Bacteriophage phi-C31 (519 aa), FASTA scores: opt: 331, E(): 6.5e-15, (28.5% identity in 235 aa overlap); and C-terminus to whole of Q38031 ORF10 of Bacteriophage phi-C31 (202 aa), FASTA scores: opt: 353, E(): 1e-16, (31.1% identity in 190 aa overlap). Also similar to part of AB016282|AB016282_42 Bacteriophage phi-105 (806 aa), FASTA scores: opt: 790, E(): 0, (32.7% identity in 459 aa overlap). Similarity to other phage proteins described as putative DNA-polymerase or DNA-primase. Also slightly similar to MTCY441.24c, FASTA scores: E(): 0.0055, (36.0% identity in 75 aa overlap).; phiRv1 phage protein	complement(1784497..1785912)	Mycobacterium tuberculosis H37Rv	886311
NP_216099.1	CDS	Rv1583c	NC_000962.2	1785912	1786310	R	Rv1583c, (MTCY336.21), len: 132 aa. Probable phiRv1 phage protein (see citation below), highly similar to Rv2656c|MTCY441.25c phiRV2 phage protein (130 aa), FASTA score: E(): 1.3e-33, (81.7% identity in 131 aa overlap). TBparse score is 0.912.; phiRv1 phage protein	complement(1785912..1786310)	Mycobacterium tuberculosis H37Rv	886315
NP_216100.1	CDS	Rv1584c	NC_000962.2	1786307	1786528	R	Rv1584c, (MTCY336.20), len: 73 aa. Possible phiRv1 phage protein (putative excisionase) (see citation below). TBparse score is 0.883.; phiRv1 phage protein	complement(1786307..1786528)	Mycobacterium tuberculosis H37Rv	886307
NP_216101.1	CDS	Rv1585c	NC_000962.2	1786584	1787099	R	Rv1585c, (MTCY336.19), len: 171 aa. Possible phage phiRv1 protein (see Hatfull 2000). TBparse score is 0.926.; phiRv1 phage protein	complement(1786584..1787099)	Mycobacterium tuberculosis H37Rv	886309
NP_216102.1	CDS	Rv1586c	NC_000962.2	1787096	1788505	R	Rv1586c, (MTCY336.18), len: 469 aa. Probable phiRv1 integrase, possibly member of the serine family of recombinases (see citation below), similar to several bacteriophage integrases e.g. Q37839 ORF469 PROTEIN from Bacteriophage R4 (469 aa), FASTA scores: opt: 623, E(): 1.6e-29, (31.1% identity in 482 aa overlap); and Bacteriophage TP901-1.; phiRv1 integrase	complement(1787096..1788505)	Mycobacterium tuberculosis H37Rv	886305
NP_216103.2	CDS	Rv1587c	NC_000962.2	1788162	1789163	R	Rv1587c, (MTCY336.17), len: 333 aa. Partial REP13E12 repeat protein (see citation below), nearly identical (but has been interrupted by phiRv1 prophage) to Q50655|MTCY251.13c|Rv0094c HYPOTHETICAL 34.6 kDa PROTEIN from M. tuberculosis (317 aa), FASTA results: opt: 1511, E(): 1.1e-84, (97.75% identity in 224 aa overlap). Codon usage suggests that translation may involve frameshifting of Rv1588c mRNA in poly_C stretch into reading frame of Rv1587c. 3' end found in Rv1572c. Lenght extended since first submission (+115 aa).; REP13E12 repeat-containing protein	complement(1788162..1789163)	Mycobacterium tuberculosis H37Rv	886303
NP_216104.1	CDS	Rv1588c	NC_000962.2	1789168	1789836	R	Rv1588c, (MTCY336.16), len: 222 aa. Partial REP13E12 repeat protein (see citation below), nearly identical to ORF's in other Rep13E12 repeats, including Rv0095c|MTCY251.14c|Y05E_MYCTU|Q10891 hypothetical 15.4 kd protein cy251.14 from Mycobacterium tuberculosis (136 aa), FASTA results: opt: 613, E(): 9.9e-29, (86.5% identity in 111 aa overlap).; REP13E12 repeat-containing protein	complement(1789168..1789836)	Mycobacterium tuberculosis H37Rv	886325
NP_216105.1	CDS	bioB	NC_000962.2	1790284	1791333	D	catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase	1790284..1791333	Mycobacterium tuberculosis H37Rv	886301
NP_216106.1	CDS	Rv1590	NC_000962.2	1791334	1791573	D	Rv1590, (MTCY336.14c), len: 79 aa. Conserved hypothetical protein, similar to Q49616|LEPB1170_C1_162|YF90_MYCLE from Mycobacterium leprae (80 aa), FASTA scores: opt: 368, E(): 1.7e-21, Smith-Waterman score: 368, (67.1% identity in 73 aa overlap). TBparse score is 0.909; hypothetical protein	1791334..1791573	Mycobacterium tuberculosis H37Rv	886292
NP_216107.1	CDS	Rv1591	NC_000962.2	1791570	1792235	D	Rv1591, (MTCY336.13c), len: 221 aa. Probable transmembrane protein, similar to Q49626|LEPB1170_C3_229|YF91_MYCLE Hypothetical Mycobacterium leprae protein (198 aa), FASTA results: opt: 802, E(): 0, (63.8% identity in 188 aa overlap). TBparse score is 0.912.; hypothetical protein	1791570..1792235	Mycobacterium tuberculosis H37Rv	886295
NP_216108.1	CDS	Rv1592c	NC_000962.2	1792400	1793740	R	Rv1592c, (MTCY336.12), len: 446 aa. Conserved hypothetical protein, some similarity to Q49629|B1170_F1_46 from Mycobacterium leprae (132 aa), FASTA results: opt: 332, E(): 4.5e-14, (56.3% identity in 87 aa overlap). Nearly identical to truncated Mycobacterium bovis BCG protein (148 aa) AF041819|AF041819_11. TBparse score is 0.918.; hypothetical protein	complement(1792400..1793740)	Mycobacterium tuberculosis H37Rv	886287
NP_216109.1	CDS	Rv1593c	NC_000962.2	1793997	1794707	R	Rv1593c, (MTCY336.11), len: 236 aa. Conserved hypothetical protein, highly similar to Q49628|B1170_F1_44 from Mycobacterium leprae (286 aa), FASTA scores: opt: 1304, E (): 0, (85.4% identity in 233 aa overlap); similar to several putative DNA hydrolases e.g. Q9S233|SCI51.07C from Streptomyces coelicolor (239 aa), FASTA scores: opt: 415, E(): 4.6e-20, (34.8% identity in 221 aa overlap); also similar to P74291|SLR1690 hypothetical protein from synechocystis (261 aa), FASTA scores: opt: 228, E(): 1.4e-17, (31.5% identity in 213 aa overlap). TBparse score is 0.922; hypothetical protein	complement(1793997..1794707)	Mycobacterium tuberculosis H37Rv	886289
NP_216110.1	CDS	nadA	NC_000962.2	1794756	1795805	D	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase	1794756..1795805	Mycobacterium tuberculosis H37Rv	886283
NP_216111.1	CDS	nadB	NC_000962.2	1795805	1797388	D	catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase	1795805..1797388	Mycobacterium tuberculosis H37Rv	886285
NP_216112.1	CDS	nadC	NC_000962.2	1797388	1798245	D	catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase	1797388..1798245	Mycobacterium tuberculosis H37Rv	886281
NP_216113.1	CDS	Rv1597	NC_000962.2	1798294	1799052	D	Rv1597, (MTCY336.07c), len: 252 aa. Hypothetical unknown protein.; hypothetical protein	1798294..1799052	Mycobacterium tuberculosis H37Rv	886297
NP_216114.1	CDS	Rv1598c	NC_000962.2	1799073	1799483	R	Rv1598c, (MTCY336.06), len: 136 aa. Conserved hypothetical protein, some similarity to O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis (131 aa), FASTA scores: E(): 2.2e-09, (38.4% identity in 99 aa overlap); and P95144|MTCY359.02|Rv1871c (129 aa).; hypothetical protein	complement(1799073..1799483)	Mycobacterium tuberculosis H37Rv	886324
NP_216115.1	CDS	hisD	NC_000962.2	1799583	1800899	D	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase	1799583..1800899	Mycobacterium tuberculosis H37Rv	886277
YP_177823.1	CDS	hisC1	NC_000962.2	1800896	1802038	D	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase	1800896..1802038	Mycobacterium tuberculosis H37Rv	886298
NP_216117.1	CDS	hisB	NC_000962.2	1802035	1802667	D	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase	1802035..1802667	Mycobacterium tuberculosis H37Rv	886274
NP_216118.1	CDS	hisH	NC_000962.2	1802664	1803284	D	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH	1802664..1803284	Mycobacterium tuberculosis H37Rv	885529
NP_216119.1	CDS	hisA	NC_000962.2	1803294	1804031	D	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A	1803294..1804031	Mycobacterium tuberculosis H37Rv	885873
NP_216120.1	CDS	impA	NC_000962.2	1804039	1804851	D	Rv1604, (MTV046.02), len: 270 aa. Probable impA, inositol monophosphatase (EC 3.1.3.25), similar to many e.g. AF0059|AF005905_2 inositol monophosphate phosphatase from Mycobacterium smegmatis (276 aa), FASTA scores: opt: 1241, E(): 0, (70.5% identity in 261 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv3137 and Rv2701c.; inositol-monophosphatase	1804039..1804851	Mycobacterium tuberculosis H37Rv	885567
NP_216121.1	CDS	hisF	NC_000962.2	1804853	1805656	D	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF	1804853..1805656	Mycobacterium tuberculosis H37Rv	885261
NP_216638.2	CDS	hisI	NC_000962.2	1805653	1806000	D	PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase	1805653..1806000	Mycobacterium tuberculosis H37Rv	886011
NP_216123.1	CDS	chaA	NC_000962.2	1806181	1807263	D	Rv1607, (MTV046.05), len: 360 aa. Probable chaA, ionic transporter integral membrane protein, putative calcium/proton antiporter, similar to many e.g. P31801|CHAA_ECOLI CALCIUM/PROTON ANTIPORTER from Escherichia coli (366 aa), FASTA scores: opt: 736, E(): 0, (35.9% identity in 351 aa overlap). Equivalent to Mycobacterium leprae AL049913|MLCB1610_21 (77.7% identity in 364 aa overlap). SEEMS TO BELONG TO THE CaCA FAMILY. TBparse score is 0.888.; ionic transporter integral membrane protein chaA	1806181..1807263	Mycobacterium tuberculosis H37Rv	885524
NP_216124.1	CDS	bcpB	NC_000962.2	1807298	1807762	R	Rv1608c, (MTV046.06), len: 154 aa. Probable bcpB, peroxidoxin or bacterioferritin comigratory protein, similar to many, e.g. AE0003|ECAE000335_4 bacterioferritin comigratory protein from Escherichia coli K-12 MG1655 (156 aa), FASTA scores: opt: 329, E(): 1.2e-16, (38.2% identity in 152 aa overlap); Z97179|MLCL383_22 Mycobacterium leprae cosmid L383 (161 aa) (40.2% identity in 132 aa overlap). Also similar to Rv2428 AhpC, alkyl hydroperoxide reductase from Mycobacterium tuberculosis; and other Mycobacterium tuberculosis putative peroxidoxins Rv2521, Rv2238c, Rv1932.; peroxidoxin BcpB	complement(1807298..1807762)	Mycobacterium tuberculosis H37Rv	885530
NP_216125.1	CDS	trpE	NC_000962.2	1807903	1809453	D	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I	1807903..1809453	Mycobacterium tuberculosis H37Rv	885040
NP_216126.1	CDS	Rv1610	NC_000962.2	1809443	1810150	D	Rv1610, (MTCY01B2.02), len: 235 aa. Possible conserved membrane protein. Equivalent to AL049913|MLCB1610_23 hypothetical protein from Mycobacterium leprae (264 aa), FASTA score: (65.8% identity in 231 aa overlap).; hypothetical protein	1809443..1810150	Mycobacterium tuberculosis H37Rv	885293
NP_216127.1	CDS	trpC	NC_000962.2	1810240	1811058	D	involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase	1810240..1811058	Mycobacterium tuberculosis H37Rv	885294
NP_216128.1	CDS	trpB	NC_000962.2	1811127	1812359	D	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta	1811127..1812359	Mycobacterium tuberculosis H37Rv	885297
NP_216129.1	CDS	trpA	NC_000962.2	1812359	1813171	D	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha	1812359..1813171	Mycobacterium tuberculosis H37Rv	885291
NP_216130.1	CDS	lgt	NC_000962.2	1813171	1814577	D	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase	1813171..1814577	Mycobacterium tuberculosis H37Rv	885292
NP_216131.1	CDS	Rv1615	NC_000962.2	1815253	1815693	D	Rv1615, (MTCY01B2.07), len: 146 aa. Probable membrane protein; hypothetical protein	1815253..1815693	Mycobacterium tuberculosis H37Rv	885499
NP_216132.1	CDS	Rv1616	NC_000962.2	1815683	1816081	D	Rv1616, (MTCY01B2.08), len: 132 aa. Conserved membrane protein, with some similarity to other hypothetical proteins e.g. AL096884|SC4G6_9 from Streptomyces coelicolor cosmid 4G6 (148 aa), FASTA scores: opt: 245, E(): 1.7e-1 0, (36.7% identity in 128 aa overlap); Q55401|SLL0543 HYPOTHETICAL 16.5 kDa PROTEIN from SYNECHOCYSTIS SP (148 aa), FASTA scores: opt: 225, E(): 6.5e-10, (35.9% identity in 117 aa overlap). Has cysteine cluster and contains a rubredoxin signature (PS00202).; hypothetical protein	1815683..1816081	Mycobacterium tuberculosis H37Rv	885498
NP_216133.1	CDS	pykA	NC_000962.2	1816189	1817607	D	catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase	1816189..1817607	Mycobacterium tuberculosis H37Rv	885501
NP_216134.1	CDS	tesB1	NC_000962.2	1817615	1818517	D	Rv1618, (MTCY01B2.10), len: 300 aa. Probable tesB1, acyl-CoA thioesterase II (EC 3.1.2.-), similar to other acyl-CoA thioesterases e.g. TESB_ECOLI|P23911 acyl-coa thioesterase II from Escherichia coli (285 aa), FASTA scores: opt: 495, E(): 2.9e-27, (32.5% identity in 283 aa overlap); etc. Also similar to Rv2605c|tesB2 from M. tuberculosis.; acyl-CoA thioesterase II TesB1	1817615..1818517	Mycobacterium tuberculosis H37Rv	885500
NP_216135.1	CDS	Rv1619	NC_000962.2	1818575	1820029	D	Rv1619, (MTCY01B2.11), len: 484 aa. Conserved membrane protein. Some similarity to N-terminus of P94974|Rv1640c|MTCY06H11.04c PROBABLE LYSYL-TRNA SYNTHETASE 2 (EC 6.1.1.6) from Mycobacterium tuberculosis (1172 aa), FASTA scores: E(): 1.4e-16, (28.0% identity in 410 aa overlap); and similar in part to O69916| SC3C8.03C Putative intergral membrane protein from Streptomyces coelicolor cosmid 3C8 (589 aa), FASTA scores: opt: 453 E(): 8.4e-22, (31.3% identity in 313 aa overlap).; hypothetical protein	1818575..1820029	Mycobacterium tuberculosis H37Rv	885509
NP_216136.1	CDS	cydC	NC_000962.2	1819963	1821693	R	Rv1620c, (MTCY01B2.12c), len: 576 aa. Probable cydC, transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below), similar to others e.g. CYDC_ECOLI|P23886 transport ATP-binding protein from Escherichia coli (573 aa), FASTA scores: opt: 631, E(): 1.6e-30, (28.5% identity in 569 aa overlap); C-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa), FASTA scores: opt: 956, E(): 0, (38.8% identity in 554 aa overlap); etc. Contains (PS00211) ABC transporters family signature, and (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC	complement(1819963..1821693)	Mycobacterium tuberculosis H37Rv	885503
NP_216137.1	CDS	cydD	NC_000962.2	1821690	1823273	R	Rv1621c, (MTCY01B2.13c), len: 527 aa. Probable cydD, transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below), similar to others e.g. P94366|CYDC_BACSU TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (567 aa), FASTA scores: opt: 784, E(): 0, (30.1% identity in 535 aa overlap); N-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa), FASTA scores: opt: 1295, E(): 0, (44.6% identity in 534 aa overlap); etc. Also similar to Q11019|Y07D_MYCTU from Mycobacterium tuberculosis (579 aa), FASTA scores: opt: 530, E(): 6.9e-25, (29.1% identity in 530 aa overlap). Contains (PS00211) ABC transporters family signature, and (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD	complement(1821690..1823273)	Mycobacterium tuberculosis H37Rv	885512
NP_216138.1	CDS	cydB	NC_000962.2	1823360	1824400	R	Rv1622c, (MTCY01B2.14c), len: 346 aa. Probable cydB, cytochrome D ubiquinol oxidase subunit II (EC 1.10.3.-), integral membrane protein, similar to others e.g. P11027|CYDB_ECOLI CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II from Escherichia coli strain K12 (379 aa), FASTA scores: opt: 519, E(): 0, (32.3% identity in 372 aa overlap); P94365|CYDB_BACSU CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II from Bacillus subtilis (338 aa), FASTA scores: opt: 824, E(): 0, (39.5% identity in 337 aa overlap); etc.; integral membrane cytochrome D ubiquinol oxidase (subunit II) cydB (cytochrome bd-I oxidase subunit II)	complement(1823360..1824400)	Mycobacterium tuberculosis H37Rv	885510
YP_177824.1	CDS	cydA	NC_000962.2	1824430	1825887	R	Rv1623c, (MTCY01B2.15c), len: 485 aa. Probable cydA (previously known as appC, but renamed cydA to conform with Mycobacterium smegmatis nomenclature), cytochrome D ubiquinol oxidase subunit I (EC 1.10.3.-), integral membrane protein, similar to others e.g. P26459|APPC_ECOLI|CYXA|CBDA|B0978 CYTOCHROME BD-II OXIDASE SUBUNIT I from Escherichia coli strain K12 (514 aa), FASTA scores: opt: 870, E(): 0, (35.9% identity in 485 aa overlap); AL034355|SCD78_12 from Streptomyces coelicolor (501 aa), FASTA scores: opt: 1099, E(): 0, (48.6% identity in 510 aa overlap); etc.; appC; integral membrane cytochrome D ubiquinol oxidase (subunit I) cydA (cytochrome bd-I oxidase subunit I)	complement(1824430..1825887)	Mycobacterium tuberculosis H37Rv	885446
NP_216140.1	CDS	Rv1624c	NC_000962.2	1825998	1826585	R	Rv1624c, (MTCY01B2.16c), len: 195 aa. Probable membrane protein, first start taken. Some similarity to Rv3155 nuoK, NADH dehydrogenase chain K from M. tuberculosis. Also similar to AAK72093.1|AF196488 hypothetical protein from Mycobacterium smegmatis (205 aa). Identities = 117/195 (60%).; hypothetical protein	complement(1825998..1826585)	Mycobacterium tuberculosis H37Rv	885135
NP_216141.2	CDS	cya	NC_000962.2	1826614	1827945	R	Rv1625c, (MT1661, MTCY01B2.17c), len: 418 aa. cya, membrane-anchored adenylyl cyclase (EC 4.6.1.1) (see citations below). C-terminal half is similar to region in numerous eukaryotic adenylate and guanylate cyclases. N-terminal half hydrophobic. FASTA score: CYG2_RAT|P22717 guanylate cyclase soluble, beta-2 chain (682 aa), FASTA scores: opt: 552, E(): 2.7e-26, (40.3% identity in 226 aa overlap). Some similarity to Rv2435c|MTCY428.11 from Mycobacterium tuberculosis (730 aa), E(): 7e-19. Start changed since first submission (+25 aa). BELONGS TO ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY.; membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase) (adenylate cyclase)	complement(1826614..1827945)	Mycobacterium tuberculosis H37Rv	888538
NP_216142.1	CDS	Rv1626	NC_000962.2	1828180	1828797	D	Rv1626, (MTCY01B2.18), len: 205 aa. Probable two-component response system transcriptional regulator, similar to many e.g. CHEY_BACSU|P24072 chemotaxis protein chey homolog (119 aa), FASTA scores: opt: 283, E(): 1.6e-16, (43.0% identity in 114 aa overlap). Also similar to AL109732|SC7H2_27 hypothetical protein from Streptomyces coelicolor (218 aa), opt: 880, E(): 0, (69.4% identity in 196 aa overlap).; two-component system transcriptional regulator	1828180..1828797	Mycobacterium tuberculosis H37Rv	885080
NP_216143.1	CDS	Rv1627c	NC_000962.2	1828865	1830073	R	Rv1627c, (MTCY01B2.19c), len: 402 aa. Probable nonspecific lipid-transfer protein, similar to many lipid carrier proteins e.g. Q51797 ACETYL CoA SYNTHASE from Pyrococcus furiosus (388 aa), FASTA scores: opt: 400, E(): 3.2e-18, (34.4% identity in 407 aa overlap); etc. Also some similarity to Mycobacterium tuberculosis proteins Rv3523, Rv3540c, Rv0244, Rv2790c, Rv1323, etc.; lipid-transfer protein	complement(1828865..1830073)	Mycobacterium tuberculosis H37Rv	885064
NP_216144.1	CDS	Rv1628c	NC_000962.2	1830070	1830561	R	Rv1628c, (MTCY01B2.20c), len: 163 aa. Conserved hypothetical protein, some similarity to others e.g. Q51796 ACAC PROTEIN in Pyrococcus furiosus (136 aa), FASTA scores: opt: 199, E(): 4.6e-06, (34.7% identity in 121 aa overlap); hypothetical protein	complement(1830070..1830561)	Mycobacterium tuberculosis H37Rv	885289
NP_216145.1	CDS	polA	NC_000962.2	1830665	1833379	D	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I	1830665..1833379	Mycobacterium tuberculosis H37Rv	885074
NP_216146.1	CDS	rpsA	NC_000962.2	1833542	1834987	D	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1	1833542..1834987	Mycobacterium tuberculosis H37Rv	885188
NP_216147.1	CDS	coaE	NC_000962.2	1835013	1836236	D	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein	1835013..1836236	Mycobacterium tuberculosis H37Rv	885165
NP_216148.1	CDS	Rv1632c	NC_000962.2	1836387	1836830	R	Rv1632c, (MTCY01B2.24c), len: 147 aa. Hypothetical unknown protein.; hypothetical protein	complement(1836387..1836830)	Mycobacterium tuberculosis H37Rv	885649
NP_216149.1	CDS	uvrB	NC_000962.2	1837075	1839171	D	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B	1837075..1839171	Mycobacterium tuberculosis H37Rv	885249
NP_216150.1	CDS	Rv1634	NC_000962.2	1839168	1840583	D	Rv1634, (MTCY01B2.26), len: 471 aa. Possible drug efflux membrane protein of major facilitator superfamily (MFS), similar to many antibiotic resistance (efflux) proteins. FASTA best: Q56175 TU22 DTDP-GLUCOSE DEHYDRTATASE (GRAE) from Streptomyces violaceoruber (557 aa), opt: 415, E(): 1.7e-17, (26.7% identity in 446 aa overlap). Relatives in Mycobacterium tuberculosis: MTCY369.27c, E(): 4.8e-12; MTCY20B11.14c, E(): 2.9e-10.; drug efflux membrane protein	1839168..1840583	Mycobacterium tuberculosis H37Rv	885115
NP_216151.1	CDS	Rv1635c	NC_000962.2	1840572	1842242	R	Rv1635c, (MTCY01B2.27c), len: 556 aa. Probable conserved transmembrane protein, equivalent to CAC31770.1|AL583921 Mycobacterium leprae membrane protein (527 aa), Identities = 332/527 (62%).; transmembrane protein	complement(1840572..1842242)	Mycobacterium tuberculosis H37Rv	885100
NP_216152.1	CDS	TB15.3	NC_000962.2	1842451	1842891	D	Rv1636, (MTCY01B2.28), len: 146 aa. TB15.3, iron-regulated conserved hypothetical protein (see citations below), similar to other hypothetical proteins from diverse organisms e.g. Q57951|MJ0531|Y531_METJA from Methanococcus jannaschii (170 aa), FASTA scores: opt: 188, E(): 6e-06, (32.2% identity in 149 aa overlap); also P42297|YXIE_BACSU hypothetical 15.9 kDa protein in bglh-wapa intergenic region precursor from Bacillus subtilis (148 aa), FASTA scores: opt: 162, E(): 0.00025, (30.8% identity in 156 aa overlap). Part of family of Mycobacterium tuberculosis hypothetical proteins (but lacks C-terminal region) including Rv2005c, Rv2623, Rv2026c, Rv1996, etc.; hypothetical protein	1842451..1842891	Mycobacterium tuberculosis H37Rv	885473
NP_216153.1	CDS	Rv1637c	NC_000962.2	1842898	1843692	R	Rv1637c, (MTCY01B2.29c,MTCY06H11.01c), len: 264 aa. Conserved hypothetical protein, some similarity to others e.g. P05446|GLO2_RHOBL PROBABLE HYDROXYACYLGLUTATHIONE HYDROLASE (EC 3.1.2.6) (255 aa), FASTA scores: opt: 252, E(): 2e-09, (39.0% identity in 146 aa overlap). Also similar to Q9Z505|AL035591|SCC54.20 putative hydrolase from Streptomyces coelicolor (218 aa), FASTA scores: opt: 732, E(): 0, (52.3% identity in 220 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins and putative glyoxylases e.g. Rv0634c, Rv3677c, Rv2581c, Rv2260.; hypothetical protein	complement(1842898..1843692)	Mycobacterium tuberculosis H37Rv	885132
NP_216154.1	CDS	uvrA	NC_000962.2	1843741	1846659	D	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A	1843741..1846659	Mycobacterium tuberculosis H37Rv	885685
YP_177650.1	CDS	Rv1638A	NC_000962.2	1846716	1846973	R	Rv1638A, len: 85 aa. Conserved hypothetical protein, similar to C-terminal part of P31511|35KD_MYCTU 35kd immunogenic protein from Mycobacterium tuberculosis (270 aa), FASTA scores: opt: 159, E(): 0.002, (50.90% identity in 55 aa overlap); and to Mycobacterium leprae ML0981 possible pseudogene, an orthologue of 35kd immunogenic protein from Mycobacterium tuberculosis. Size difference suggests possible gene fragment.; hypothetical protein	complement(1846716..1846973)	Mycobacterium tuberculosis H37Rv	3205103
NP_216155.1	CDS	Rv1639c	NC_000962.2	1846989	1848458	R	Rv1639c, (MTCY06H11.03c), len: 489 aa. Conserved hypothetical membrane protein. Some similarity to P35866|YLI2_CORGL Hypothetical 45.7 kDa protein from Corynebacterium glutamicum (426 aa), FASTA scores: opt: 511, E( ): 2.4e-23, (28.9% identity in 370 aa overlap). Contains PS00904 protein phenyltransferases alpha subunit repeat signature; hypothetical protein	complement(1846989..1848458)	Mycobacterium tuberculosis H37Rv	885642
NP_216156.1	CDS	lysS	NC_000962.2	1848517	1852035	R	catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase	complement(1848517..1852035)	Mycobacterium tuberculosis H37Rv	885428
NP_216157.1	CDS	infC	NC_000962.2	1852273	1852878	D	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3	1852273..1852878	Mycobacterium tuberculosis H37Rv	885478
NP_216158.1	CDS	rpmI	NC_000962.2	1852928	1853122	D	Rv1642, (MTCY06H11.06), len: 64 aa. Probable rpmI, 50S ribosomal protein L35, similar to several e.g. RL35_SYNY3|P48959 from Synechocystis sp. (67 aa), fasta scores: opt: 179, E(): 2.7e-08, (51.6% identity in 64 aa overlap). BELONGS TO THE L35P FAMILY OF RIBOSOMAL PROTEINS.; 50S ribosomal protein L35	1852928..1853122	Mycobacterium tuberculosis H37Rv	885145
NP_216159.1	CDS	rplT	NC_000962.2	1853184	1853573	D	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20	1853184..1853573	Mycobacterium tuberculosis H37Rv	885455
NP_216160.1	CDS	tsnR	NC_000962.2	1853606	1854388	D	Rv1644, (MTCY06H11.08), len: 260 aa. Possible tsnR, 23S rRNA methyltransferase (EC 2.1.1.-), similar to several e.g. TSNR_STRLU|P52393 from Streptomyces laurentii (270 aa), FASTA scores: opt: 276, E(): 3.6e-11, (27.6% identity in 261 aa overlap). Also similar to M. tuberculosis hypothetical proteins Rv0881, Rv3579c, and Rv0380c.; 23S rRNA methyltransferase TsnR	1853606..1854388	Mycobacterium tuberculosis H37Rv	885163
NP_216161.1	CDS	Rv1645c	NC_000962.2	1854399	1855454	R	Rv1645c, (MTCY06H11.10c), len: 351 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O53837|Rv0826|MTV043.18 (351 aa), FASTA scores: (57.5% identity in 299 aa overlap); Q10519|Rv2237|YM37_MYCTU (255 aa), O53682|Rv0276 (306 aa).; hypothetical protein	complement(1854399..1855454)	Mycobacterium tuberculosis H37Rv	885287
YP_177825.1	CDS	PE17	NC_000962.2	1855764	1856696	D	Rv1646, (MTCY06H11.11), len: 310 aa. Member of the Mycobacterium tuberculosis PE family of proteins (see citation below), similar to many e.g. YW36_MYCTU|Q10873 hypothetical 53.7 kd protein cy39.36c (558 aa), FASTA scores, opt: 411, E(): 1.3e-15, (34.4% identity in 320 aa overlap).; PE family protein	1855764..1856696	Mycobacterium tuberculosis H37Rv	885486
NP_216163.1	CDS	Rv1647	NC_000962.2	1856774	1857724	D	Rv1647, (MTCY06H11.12), len: 316 aa. Conserved hypothetical protein, some similarity to other Mycobacterium tuberculosis hypothetical proteins e.g. Q11055|Rv1264|YC64_MYCTU Hypothetical 42.2 kDa protein (397 aa), FASTA scores: opt: 197, E(): 9.4e-06, (27.1% identity in 181 aa overlap) and Q10400|Rv2212|YM12_MYCTU (378 aa).; hypothetical protein	1856774..1857724	Mycobacterium tuberculosis H37Rv	885432
NP_216164.1	CDS	Rv1648	NC_000962.2	1857731	1858537	D	Rv1648, (MTCY06H11.13), len: 268 aa. Probable transmembrane protein, some similarity to Rv3434c|MTCY77.06C (237 aa), FASTA scores: E(): 0.00039, (31.4% identity in 194 aa overlap).; transmembrane protein	1857731..1858537	Mycobacterium tuberculosis H37Rv	885065
NP_216165.1	CDS	pheS	NC_000962.2	1858733	1859758	D	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha	1858733..1859758	Mycobacterium tuberculosis H37Rv	885105
NP_216166.1	CDS	pheT	NC_000962.2	1859758	1862253	D	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta	1859758..1862253	Mycobacterium tuberculosis H37Rv	885283
YP_177826.1	CDS	PE_PGRS30	NC_000962.2	1862347	1865382	R	Rv1651c, (MTCY06H11.16c), len: 1011 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citations below), similar to many e.g. Q10637|Y03A_MYCTU hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt: 1757, E(): 0, (50.8% identity in 714aa overlap). The transcription of this CDS seems to be activated in macrophages (see Ramakrishnan et al., 2000).; PE-PGRS family protein	complement(1862347..1865382)	Mycobacterium tuberculosis H37Rv	885174
NP_216168.1	CDS	argC	NC_000962.2	1865576	1866634	D	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase	1865576..1866634	Mycobacterium tuberculosis H37Rv	885278
NP_216169.1	CDS	argJ	NC_000962.2	1866631	1867845	D	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein	1866631..1867845	Mycobacterium tuberculosis H37Rv	885125
NP_216170.1	CDS	argB	NC_000962.2	1867842	1868726	D	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase	1867842..1868726	Mycobacterium tuberculosis H37Rv	888076
NP_216171.1	CDS	argD	NC_000962.2	1868723	1869925	D	catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase	1868723..1869925	Mycobacterium tuberculosis H37Rv	885187
NP_216172.1	CDS	argF	NC_000962.2	1869922	1870845	D	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase	1869922..1870845	Mycobacterium tuberculosis H37Rv	885462
NP_216173.1	CDS	argR	NC_000962.2	1870842	1871354	D	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor	1870842..1871354	Mycobacterium tuberculosis H37Rv	885091
NP_216174.1	CDS	argG	NC_000962.2	1871363	1872559	D	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase	1871363..1872559	Mycobacterium tuberculosis H37Rv	885645
NP_216175.1	CDS	argH	NC_000962.2	1872639	1874051	D	catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase	1872639..1874051	Mycobacterium tuberculosis H37Rv	885365
NP_216176.1	CDS	pks10	NC_000962.2	1874160	1875221	D	Rv1660, (MTCY06H11.25), len: 353 aa. Possible pks10, chalcone synthase (EC 2.3.1.74), similar to BCSA_BACSU|P54157 putative chalcone synthase from B. subtilis (365 aa), FASTA scores: opt: 701, E(): 0, (33.1% identity in 362 aa overlap). Also similar to M. tuberculosis Rv1665|pks11 polyketide synthase (chalcone synthase); and Rv1372|pks18 polyketide synthase. Other upstream initiation sites are possible but homology suggests this start.; chalcone synthase	1874160..1875221	Mycobacterium tuberculosis H37Rv	885112
NP_216177.1	CDS	pks7	NC_000962.2	1875304	1881684	D	Rv1661, (MTCY06H11.26), len: 2126 aa. Probable pks7, polyketide synthase, similar to many e.g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 (3567 aa), FASTA scores: E(): 0, (48.8% identity in 2131 aa overlap); also similar to Mycobacterium tuberculosis pks12. Contains PS00606 Beta-ketoacyl synthases active site, PS00012 Phosphopantetheine attachment site.; polyketide synthase pks7	1875304..1881684	Mycobacterium tuberculosis H37Rv	885108
NP_216178.1	CDS	pks8	NC_000962.2	1881704	1886512	D	Rv1662, (MTCY275.01-MTCY06H11.27), len: 1602 aa. Probable pks8, polyketide synthase, similar to many polyketide synthases e.g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 from Saccharopolyspora erythraea (Streptomyces erythraeus) (3567 aa), FASTA scores: opt: 3319, E(): 0, (45.8% identity in 1619 aa overlap). Also similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks7 and pks12. Contains PS00606 Beta-ketoacyl synthases active site and PS01162 Quinone oxidoreductase/zeta-crystallin signature. Note that the similarity extends into the downstream ORF Rv1663 (MTCY275.02), and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy was found.; polyketide synthase pks8	1881704..1886512	Mycobacterium tuberculosis H37Rv	885527
NP_216179.1	CDS	pks17	NC_000962.2	1886512	1888020	D	Rv1663, (MTCY275.02), len: 502 aa. Probable pks17, polyketide synthase, similar to other polyketide synthases e g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 (3567 aa) from Saccharopolyspora erythraea (Streptomyces erythraeus), FASTA scores: opt: 1207, E(): 0, (43.9% identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks7 and pks1. Note that the similarity extends into the upstream ORF Rv1662 (MTCY275.01) and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy was found. Contains PS00012 Phosphopantetheine attachment site.; polyketide synthase pks17	1886512..1888020	Mycobacterium tuberculosis H37Rv	885523
NP_216180.1	CDS	pks9	NC_000962.2	1888026	1891079	D	Rv1664, (MTCY275.03), len: 1017 aa. Probable pks9, polyketide synthase, similar to OL56_STRAT|Q07017 oleandomycin polyketide synthase, modules 5 and 6 from Streptomyces antibioticus (3519 aa), FASTA scores: opt: 1767, E(): 0, (41.6% identity in 919 aa overlap). Similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks6, pks8, etc. Contains PS00012 Phosphopantetheine attachment site.; polyketide synthase pks9	1888026..1891079	Mycobacterium tuberculosis H37Rv	885519
NP_216181.1	CDS	pks11	NC_000962.2	1891226	1892287	D	Rv1665, (MTCY275.04-MTV047.01), len 353 aa. Possible pks11, chalcone synthase (EC 2.3.1.74), some similarity to BCSA_BACSU|P54157 putative chalcone synthase from Bacillus subtilis (365 aa), FASTA scores: opt: 615, E(): 6.2e-32, (33.4% identity in 308 aa overlap); and to many plant chalcone synthases e.g. CHS_VIGUN|P51089 chalcone synthase (EC 2.3.1.74) (388 aa), FASTA scores: opt: 391, E(): 7.8e-18, (27.2% identity in 349 aa overlap). Highly similar to upstream ORF Rv1660|MTCY06H11.25 pks10 (72.7% identity in 308 aa overlap); and Rv1372 pks18.; chalcone synthase	1891226..1892287	Mycobacterium tuberculosis H37Rv	885525
NP_216182.1	CDS	cyp139	NC_000962.2	1892270	1893562	R	Rv1666c, (MT1706, MTV047.02c), len: 430 aa. Probable cyp139, cytochrome P450 (EC 1.14.-.-), similar to many e.g. U38537|APU38537_7 from Anabaena sp. (459 aa), FASTA scores: opt: 516, E(): 1.7e-26, (25.8% identity in 418 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.; cytochrome P450 139 CYP139	complement(1892270..1893562)	Mycobacterium tuberculosis H37Rv	885528
NP_216183.1	CDS	Rv1667c	NC_000962.2	1893577	1894230	R	Rv1667c, (MTV047.03c), len: 217 aa. Probable second part of macrolide-transport ATP-binding protein ABC transporter (see citation below), with similarity to C-terminal end of putative ABC transporters/ATP binding proteins, e.g. Z99108|BSUB0005_6 ABC transporter (ATP-binding protein) homolog yfmR from Bacillus subtilis (629 aa), FASTA scores: opt: 411, E(): 6.9e-17, (37.8% identity in 217 aa overlap); etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However, sequence has been checked and no errors found, also same sequence in M. tuberculosis CSU93 and Mycobacterium bovis.; macrolide-transport ATP-binding protein ABC transporter	complement(1893577..1894230)	Mycobacterium tuberculosis H37Rv	885518
NP_216184.1	CDS	Rv1668c	NC_000962.2	1894224	1895342	R	Rv1668c, (MTV047.04c), len: 372 aa. Probable first part of macrolide-transport ATP-binding protein ABC transporter (see citation below), similar to many ATP-binding proteins ABC transporter e.g. X80735|SEABCT_1|Q54072 Saccharopolyspora erythraea ertX gene (481 aa), FASTA scores: opt: 938, E(): 0, (45.6% identity in 353 aa overlap); etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However, sequence has been checked and no error found, also same sequence in Mycobacterium tuberculosis CSU93 and Mycobacterium bovis. Contains PS00211 ABC transporters family signature and two times PS00017 ATP/GTP-binding site motif A. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; macrolide-transport ATP-binding protein ABC transporter	complement(1894224..1895342)	Mycobacterium tuberculosis H37Rv	885522
NP_216185.1	CDS	Rv1669	NC_000962.2	1895725	1896087	D	Rv1669, (MTV047.04B), len: 120 aa. Hypothetical unknown protein.; hypothetical protein	1895725..1896087	Mycobacterium tuberculosis H37Rv	885701
NP_216186.1	CDS	Rv1670	NC_000962.2	1896120	1896467	D	Rv1670, (MTV047.05), len: 115 aa. Conserved hypothetical protein, highly similar to D90908|D90908_87 Hypothetical protein of Synechocystis sp. PCC6803 complete (94 aa), FASTA scores opt: 378, E(): 3.5e-2, (55.2% identity in 96 aa overlap); also shows some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. C-terminal region of O53404|Rv1056 (254 aa), and P96817|Rv0140 (126 aa).; hypothetical protein	1896120..1896467	Mycobacterium tuberculosis H37Rv	885702
NP_216187.1	CDS	Rv1671	NC_000962.2	1896475	1896867	D	Rv1671, (MTV047.06), len: 130 aa. Probable membrane protein. Weak similarity to mercuric transport proteins.; hypothetical protein	1896475..1896867	Mycobacterium tuberculosis H37Rv	885698
NP_216188.1	CDS	Rv1672c	NC_000962.2	1896876	1898207	R	Rv1672c, (MTV047.07c), len: 443 aa. Probable conserved integral membrane transport protein, major facilitator superfamily, similar to several phthalate transporters or tartrate transporters e.g. U25634|AVU25634_2 Agrobacterium vitis plasmid pTrAB (433 aa), FASTA scores: opt: 914, E(): 0, (37.1% identity in 426 aa overlap); etc.; integral membrane transport protein	complement(1896876..1898207)	Mycobacterium tuberculosis H37Rv	885700
NP_216189.1	CDS	Rv1673c	NC_000962.2	1898300	1899232	R	Rv1673c, (MTV047.08c), len: 310 aa. Conserved hypothetical protein, shows weak similarity to P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor (369 aa), FASTA scores: E(): 8.3e-11, (26.1% identity in 330 aa overlap).; hypothetical protein	complement(1898300..1899232)	Mycobacterium tuberculosis H37Rv	885695
NP_216190.1	CDS	Rv1674c	NC_000962.2	1899260	1899916	R	Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06, (35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1.; transcriptional regulatory protein	complement(1899260..1899916)	Mycobacterium tuberculosis H37Rv	885696
NP_216191.1	CDS	Rv1675c	NC_000962.2	1900241	1900975	R	Rv1675c, (MTV047.10c), len: 244 aa. Probable transcriptional regulatory protein, weak similarity to D00496|LBATRP_7 trp operon from Lactobacillus casei (219 aa), FASTA scores: opt: 172, E(): 0.00011, (26.9% identity in 186 aa overlap).; transcriptional regulatory protein	complement(1900241..1900975)	Mycobacterium tuberculosis H37Rv	885693
NP_216192.1	CDS	Rv1676	NC_000962.2	1901047	1901751	D	Rv1676, (MTV047.11), len: 234 aa. Hypothetical unknown protein.; hypothetical protein	1901047..1901751	Mycobacterium tuberculosis H37Rv	885694
NP_216193.1	CDS	dsbF	NC_000962.2	1901748	1902296	D	Rv1677, (MTV047.12), len: 182 aa. Probable dsbF, conserved lipoprotein possibly involved in thiol:disulfide interchange. Highly similar to C-terminus of Z74024|MTCY274.09 mpt53 soluble secreted antigen precursor from Mycobacterium tuberculosis (173 aa), FASTA scores: opt: 482, E(): 3.6e-23, (52.8% identity in 142 aa overlap) . Also some similarity to P52237|TIPB_PSEFL THIOL:DISULFIDE INTERCHANGE PROTEIN TIPB PRECURSOR from Pseudomonas fluorescens (178 aa), FASTA scores: opt: 190, E(): 4.4e-05, (28.5% identity in 151 aa overlap); and P33926|DSBE_ECOLI THIOL:DISULFIDE INTERCHANGE PROTEIN from Escherichia coli (185 aa), FASTA scores: opt: 194, E(): 2.6e-05, (29.1% identity in 175 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00194 Thioredoxin family active site.; lipoprotein DsbF	1901748..1902296	Mycobacterium tuberculosis H37Rv	885690
NP_216194.1	CDS	Rv1678	NC_000962.2	1902397	1903299	D	Rv1678, (MTV047.13), len: 300 aa. Probable integral membrane protein.; integral membrane protein	1902397..1903299	Mycobacterium tuberculosis H37Rv	885691
NP_216195.1	CDS	fadE16	NC_000962.2	1903299	1904420	D	Rv1679, (MTV047.14, MTCI125.01), len: 373 aa. Possible fadE16, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to acyl/butyryl-CoA dehydrogenases e.g. NP_244665.1|NC_002570 acyl-CoA dehydrogenase from Bacillus halodurans (380 aa); NP_000008.1|NM_000017 acyl-Coenzyme A dehydrogenase from Homo sapiens (412 aa); Z99113|BSUB0010_119 from Bacillus subtilis (380 aa), FASTA scores: opt: 439, E(): 3.4e-20, (29.6% identity in 287 aa overlap); etc. Weakly similar to many dehydrogenases and to P31571|CAIA_ECOLI probable carnitine operon oxidoreductase from Escherichia coli (380 aa), FASTA scores: opt: 109, E(): 0.0066, (28.6% identity in 98 aa overlap).; acyl-CoA dehydrogenase	1903299..1904420	Mycobacterium tuberculosis H37Rv	885688
NP_216196.1	CDS	Rv1680	NC_000962.2	1904429	1905253	D	Rv1680, (MTCI125.02), len: 274 aa. Hypothetical unknown protein.; hypothetical protein	1904429..1905253	Mycobacterium tuberculosis H37Rv	885689
NP_216197.1	CDS	moeX	NC_000962.2	1905250	1906242	D	Rv1681, (MTCI125.03), len: 330 aa. Possible moeX, Molybdopterin biosynthesis protein, has weak similarity to MOAA_ECOLI|P30745 molybdenum cofactor biosynthesis protein (329 aa), FASTA scores: opt: 162, E(): 0.00081, (27.7% identity in 224 aa overlap) and to Rv3109|MTCY164.19 MoaA from Mycobacterium tuberculosis (28.5% identity in 165 aa overlap).; molybdopterin biosynthesis protein MoeX	1905250..1906242	Mycobacterium tuberculosis H37Rv	885683
NP_216198.1	CDS	Rv1682	NC_000962.2	1906403	1907320	D	Rv1682, (MTCI125.04), len: 305 aa. Probable coiled-coil structural protein, weakly similar to many paramyosins, kinesins and plectins e.g. MYSP_ONCVO|Q02171 paramyosin from onchocerca volvulus (879 aa), fasta scores: opt: 180, E():2.6e-08, (24.4% identity in 234 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical coiled-coil proteins (wag31 antigen 84) Rv2145c and Rv2927c.; coiled-coil structural protein	1906403..1907320	Mycobacterium tuberculosis H37Rv	885686
NP_216199.1	CDS	Rv1683	NC_000962.2	1907594	1910593	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	1907594..1910593	Mycobacterium tuberculosis H37Rv	885687
NP_216200.1	CDS	Rv1684	NC_000962.2	1910586	1910810	D	Rv1684, (MTCI125.06), len: 74 aa. Conserved hypothetical protein, similar to P75844|YCAR_ECOLI Protein YCAR from Escherichia coli (60 aa), FASTA scores: opt: 108, E(): 0.00022, (39.0% identity in 59 aa overlap).; hypothetical protein	1910586..1910810	Mycobacterium tuberculosis H37Rv	885680
NP_216201.1	CDS	Rv1685c	NC_000962.2	1910776	1911399	R	Rv1685c, (MTCI125.07c), len: 207 aa. Conserved hypothetical protein, some similarity to other Mycobacterium tuberculosis hypothetical regulatory proteins e.g. Q10774|Rv1556|YF56_MYCTU (202 aa), FASTA scores: opt: 111, E(): 1.7e-05, (24.1% identity in 195 aa overlap); and P95215|Rv0258c|MTCY06A4.02c (151 aa) FASTA scores: (32.9% identity in 140 aa overlap); also similar to Q9X8G9|SCE7.13C|AL049819 putative Streptomyces coelicolor transcriptional regulator (204 aa), FASTA scores: opt: 480, E(): 6.4e-25, (40.4% identity in 203 aa overlap).; hypothetical protein	complement(1910776..1911399)	Mycobacterium tuberculosis H37Rv	885682
NP_216202.1	CDS	Rv1686c	NC_000962.2	1911401	1912081	R	Rv1686c, (MTCI125.08c), len: 226 aa. Probable conserved integral membrane protein ABC transporter (see citation below), similar to AL049819|SCE7.05 putative integral membrane protein from Streptomyces coelicolor (266 aa), FASTA sacores: opt: 661, E(): 0, (45.1% identity in 226 aa overlap); and Q53627|U43537 MEMBRANE PROTEIN INVOLVED IN MITHRAMYCIN RESISTANCE from STREPTOMYCES ARGILLACEUS (233 aa), FASTA scores: opt: 222, E(): 5.4e-10, (28.7% identity in 216 aa overlap).; integral membrane protein ABC transporter	complement(1911401..1912081)	Mycobacterium tuberculosis H37Rv	885672
NP_216203.1	CDS	Rv1687c	NC_000962.2	1912153	1912920	R	Rv1687c, (MTCI125.09c), len: 255 aa. Probable conserved ATP-binding protein ABC transporter (see citation below), similar to many ABC-type transporters e.g. P55476|NODI_RHISN nodulation ATP-binding protein I from Rhizobium sp. (343 aa), FASTA scores: opt: 479, E(): 3.7e-23, (34.6% identity in 243 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis ABC-type transporters e.g. MTCY19H9.04 (34.5% identity in 238 aa overlap). Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Also contains PS00039 DEAD-box subfamily ATP-dependent helicases signature, though this may be spurious.; ABC transporter ATP-binding protein	complement(1912153..1912920)	Mycobacterium tuberculosis H37Rv	885678
NP_216204.1	CDS	mpg	NC_000962.2	1912979	1913590	D	responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase	1912979..1913590	Mycobacterium tuberculosis H37Rv	885679
NP_216205.1	CDS	tyrS	NC_000962.2	1913602	1914876	D	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase	1913602..1914876	Mycobacterium tuberculosis H37Rv	885668
NP_216206.1	CDS	lprJ	NC_000962.2	1915527	1915910	D	Rv1690, (MTCI125.12), len: 127 aa. Probable lprJ, lipoprotein; contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Weakly similar to other Mycobacterium tuberculosis hypothetical proteins with conserved cysteines e.g. Rv1804c, Rv1810, Rv3354, etc; lipoprotein LprJ	1915527..1915910	Mycobacterium tuberculosis H37Rv	885670
NP_216207.1	CDS	Rv1691	NC_000962.2	1915949	1916701	D	Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa), FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap).; hypothetical protein	1915949..1916701	Mycobacterium tuberculosis H37Rv	885665
NP_216208.1	CDS	Rv1692	NC_000962.2	1916698	1917759	D	Rv1692, (MTCI125.14), len: 353 aa. Probable phosphatase (EC 3.1.-.-), some similarity to others e.g. PNPP_SCHPO|Q00472 4-nitrophenylphosphatase (269 aa), FASTA scores: opt: 214, E(): 1.3e-10, (29.5% identity in 241 aa overlap); and to NAGD_ECOLI|P15302 nagd protein from Escherichia coli (250 aa), FASTA scores: opt: 314, E(): 9.8e-08, (28.2% identity in 245 aa overlap). Also similar to AL109848|SCI51.28 hypothetical protein from Streptomyces coelicolor (343 aa), FASTA scores: opt: 768, E(): 0, (44.8% identity in 315 aa overlap).; phosphatase	1916698..1917759	Mycobacterium tuberculosis H37Rv	885241
NP_216209.1	CDS	Rv1693	NC_000962.2	1917756	1917932	D	Rv1693, (MTCI125.15), len: 58 aa. Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58.; hypothetical protein	1917756..1917932	Mycobacterium tuberculosis H37Rv	885662
NP_216210.1	CDS	tlyA	NC_000962.2	1917940	1918746	D	Rv1694, (MTCI125.16), len: 268 aa. tlyA, cytotoxin/haemolysin homologue (see citations below), almost identical to NP_301968.1|NC_002677 cytotoxin/haemolysin homologue TlyA from Mycobacterium leprae (269 aa). TlyA homologues were also identified by PCR in Mycobacterium avium, Mycobacterium bovis BCG, but appeared absent in M. smegmatis, M. vaccae, M. kansasii, M. chelonae and M. phlei (see Wren et al., 1998). Also highly similar to CAB83047.1|AJ271681 putative haemolysin from Mycobacterium ulcerans (281 aa); and similar to HLYA_TREHY|Q06803 pore-forming haemolysin/cytotoxin virulence determinant from Treponema hyodysenteriae (240 aa), FASTA scores: opt: 514, E():3e-30, (37.3% identity in 236 aa overlap).; cytotoxin/hemolysin TlyA	1917940..1918746	Mycobacterium tuberculosis H37Rv	885396
NP_216211.1	CDS	ppnK	NC_000962.2	1918746	1919669	D	catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase	1918746..1919669	Mycobacterium tuberculosis H37Rv	885660
NP_216212.1	CDS	recN	NC_000962.2	1919683	1921446	D	Rv1696, (MTCI125.18), len: 587 aa. Probable recN, DNA repair protein (see citation below), similar to many e.g. RECN_ECOLI|P05824 dna repair protein recN (553 aa), FASTA scores: opt: 508, E(): 1.9e-33, (31.5% identity in 587 aa overlap). Equivalent to Z95117|MLCB1351_12 recN from Mycobacterium leprae (587 aa), FASTA scores: (76.1% identit y in 589 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; DNA repair protein recN (recombination protein N)	1919683..1921446	Mycobacterium tuberculosis H37Rv	885805
NP_216213.1	CDS	Rv1697	NC_000962.2	1921542	1922723	D	Rv1697, (MTCI125.19), len: 393 aa. Conserved hypothetical protein, highly similar to Q49895|MLC1351.11C|U00021 Hypothetical protein of Mycobacterium leprae from cosmid L247 (430 aa), FASTA scores: opt: 2345, E(): 0, (90.6% identity in 393 aa overlap).; hypothetical protein	1921542..1922723	Mycobacterium tuberculosis H37Rv	885045
NP_216214.1	CDS	Rv1698	NC_000962.2	1922745	1923689	D	Rv1698, (MTCI125.20), len: 314 aa. Conserved hypothetical protein, possibly exported protein with potential N-terminal signal sequence. Equivalent to Q49894|MLC1351.10C|Z95117 Hypothetical protein from Mycobacterium leprae (317 aa), FASTA scores: (77.0% identity in 317 aa overlap). Probable coiled-coil from aa 31 to 67.; hypothetical protein	1922745..1923689	Mycobacterium tuberculosis H37Rv	885047
NP_216215.1	CDS	pyrG	NC_000962.2	1923829	1925589	D	CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase	1923829..1925589	Mycobacterium tuberculosis H37Rv	885048
NP_216216.1	CDS	Rv1700	NC_000962.2	1925582	1926205	D	Rv1700, (MTCI125.22), len: 207 aa. Conserved hypothetical protein, equivalent to Q49891|MLC1351.08C|Z95117 Hypothetical protein from Mycobacterium leprae (177 aa), FASTA scores: (66.7% identity in 171 aa overlap); also similar to Q9S225|SCI51.15C|AL109848 Hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 508, E(): 1.2e-27, (43.1% identity in 197 aa overlap); similar to P54570|ADPP_BACSU ADP-RIBOSE PYROPHOSPHATASE (EC 3.6.1.13) (185 aa), FASTA scores: opt: 313, E(): 1.1e-06, (42.7% identity in 124 aa overlap).; hypothetical protein	1925582..1926205	Mycobacterium tuberculosis H37Rv	885049
NP_216217.1	CDS	xerD	NC_000962.2	1926202	1927137	D	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD	1926202..1927137	Mycobacterium tuberculosis H37Rv	885055
NP_216218.1	CDS	Rv1702c	NC_000962.2	1927211	1928575	R	Rv1702c, (MTCI125.24c), len: 454 aa. Conserved hypothetical ORF in REP13E12 degenerate repeat. Similar to other hypothetical proteins inside REP13E12 elements (often in two parts) e.g. Rv0094c|Q50655|MTCY251.13c (317 aa), FASTA scores: opt: 1284, E(): 0, (59.7% identity in 315 aa overlap); and Rv1128c, Rv1945, Rv1148c, etc.; hypothetical protein	complement(1927211..1928575)	Mycobacterium tuberculosis H37Rv	885061
NP_216219.1	CDS	Rv1703c	NC_000962.2	1929131	1929721	R	Rv1703c, (MTCI125.25c), len: 196 aa. Probable catechol-o-methyltransferase (EC 2.1.1.6), most similar to COMT_HUMAN|P21964 soluble form of mammalian catechol o-methyltransferase (271 aa), FASTA scores: opt: 405, E(): 7 .8e-29, (38.9% identity in 190 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical methyltransferases Rv0187, Rv1220c.; catechol-o-methyltransferase	complement(1929131..1929721)	Mycobacterium tuberculosis H37Rv	885066
NP_216220.1	CDS	cycA	NC_000962.2	1929786	1931456	R	Rv1704c, (MTCI125.26c), len: 556 aa. Probable cycA, D-serine/D-alanine/glycine transporter, highly similar to P39312|CYCA_ECOLI d-serine/d-alanine/glycine transporter from Escherichia coli (470 aa), FASTA scores: opt: 1906, E(): 0, (59.3% identity in 459 aa overlap); etc. Also similar to other Mycobacterium tuberculosis amino-acid permeases e.g. Rv2127, Rv0346c, etc. Contains PS00218 amino acid permeases signature. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY).; D-serine/alanine/glycine transporter protein CycA	complement(1929786..1931456)	Mycobacterium tuberculosis H37Rv	888812
YP_177827.1	CDS	PPE22	NC_000962.2	1931497	1932654	R	Rv1705c, (MTCI125.27c), len: 385 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.2 3 (404 aa), fasta scores: opt: 819, E(): 0, (46.2% identity in 413 aa overlap).; PPE family protein	complement(1931497..1932654)	Mycobacterium tuberculosis H37Rv	885068
YP_177828.1	CDS	PPE23	NC_000962.2	1932694	1933878	R	Rv1706c, (MTCI125.28c), len: 394 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap).; PPE family protein	complement(1932694..1933878)	Mycobacterium tuberculosis H37Rv	885070
YP_177651.1	CDS	Rv1706A	NC_000962.2	1934482	1934649	R	Rv1706A, len: 55 aa. Conserved hypothetical protein, similar to part of several probable export proteins e.g. Rv0783c|Z80226_28 from Mycobacterium tuberculosis (540 aa), FASTA scores: opt: 125, E(): 0.011, (52.85% identity in 53 aa overlap). Size difference suggests possible gene fragment.; hypothetical protein	complement(1934482..1934649)	Mycobacterium tuberculosis H37Rv	3205102
NP_216223.1	CDS	Rv1707	NC_000962.2	1934882	1936342	D	Rv1707, (MTCI125.29), len: 486 aa. Probable conserved transmembrane protein, possibly involved in transport of sulfate, similar to several hypothetical proteins belonging to the sulfate permease family e.g. P40877|YCHM_ECOLI hypothetical 58.4 kDa protein in pth-prsa intergenic region from Escherichia coli (550 aa), FASTA scores: opt: 486, E(): 0, (33.1% identity in 492 aa overlap). Also similar to many other Mycobacterium tuberculosis membrane proteins e.g. Rv3273, Rv1739c. SEEMS TO BELONG TO THE SULP FAMILY.; transmembrane protein	1934882..1936342	Mycobacterium tuberculosis H37Rv	885073
NP_216224.1	CDS	Rv1708	NC_000962.2	1936360	1937316	D	Rv1708, (MTCI125.30), len: 318 aa. Putative initiation inhibitor protein, a soj-related protein probably involved in cell process, highly similar to many sporulation initiation inhibitor proteins soj e.g. P37522|SOJ_BACSU Soj protein from Bacillus subtilis (253 aa), FASTA scores: opt: 745, E(): 0, (46.0% identity in 248 aa overlap), and more weakly to various repA/para/incC proteins from various organisms e.g. Y4CK_RHISN|P55393 putative replication protein A from Rhizobium sp. (407 aa), FASTA scores: opt: 205, E(): 4e-13, (29.0% identity in 252 aa overlap). Also similar to Mycobacterium tuberculosis hyothetical proteins Rv3213c and Rv3918c.; putative initiation inhibitor protein	1936360..1937316	Mycobacterium tuberculosis H37Rv	885082
NP_216225.1	CDS	Rv1709	NC_000962.2	1937313	1938149	D	Rv1709, (MTCI125.31), len: 278 aa. Conserved hypothetical protein, similar to others e.g. P35154|YPUG_BACSU from Bacillus subtilis (251 aa), FASTA scores: opt: 271, E(): 8.2e-10, (27.0% identity in 248 aa overlap); Q9S230|SCI51.10C|AL109848 from Streptomyces coelicolor (264 aa), FASTA scores: opt: 855, E(): 0, (56.8% identity in 257 aa overlap). Equivalent to Q49888|MLC1351.05C|Z95117 from Mycobacterium leprae (268 aa), FASTA scores: (78.9% identity in 251 aa overlap).; hypothetical protein	1937313..1938149	Mycobacterium tuberculosis H37Rv	885083
NP_216226.1	CDS	Rv1710	NC_000962.2	1938146	1938841	D	Rv1710, (MTCI125.32), len: 231 aa. Conserved hypothetical protein, similar to several hypothetical proteins e.g. P35155|YPUH_BACSU from Bacillus subtilis (197 aa), FASTA scores: opt: 339, E(): 1.3e-09, (36.0% identity in 186 aa overlap); Q9S231|SCI51.09C|AL109848 from Streptomyces coelicolor (223 aa), FASTA scores: opt: 626, E(): 0, (51.0% identity in 192 aa overlap). Equivalent to O05669|MLC1351.04C|Z95117 Hypothetical protein from Mycobacterium leprae (231 aa), FASTA scores: (77.9% identity in 231 aa overlap).; hypothetical protein	1938146..1938841	Mycobacterium tuberculosis H37Rv	885116
NP_216227.1	CDS	Rv1711	NC_000962.2	1938838	1939602	D	Rv1711, (MTCI125.33), len: 254 aa. Conserved hypothetical protein, highly similar to a large family of hypothetical proteins e.g. P37765|YCIL_ECOLI from Escherichia coli (291 aa), FASTA scores: opt: 496, E(): 1.1e-29, (41.6% identity in 250 aa overlap); 9S232|SCI51.08C|AL109848 PUTATIVE PSEUDOURIDINE SYNTHASE from Streptomyces coelicolor (371 aa), FASTA scores: opt: 818, E(): 0, (53.1% identity in 245 aa overlap). Equivalent to O05668|MLCB1351.03C|Z95117 Hypothetical protein from Mycobacterium leprae (256 aa), (80.5% identity in 256 aa overlap). Contains PS01149 Hypothetical yciL/yejD/yjbC family signature.; hypothetical protein	1938838..1939602	Mycobacterium tuberculosis H37Rv	885122
NP_216228.1	CDS	cmk	NC_000962.2	1939599	1940291	D	Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase	1939599..1940291	Mycobacterium tuberculosis H37Rv	885157
NP_216229.1	CDS	engA	NC_000962.2	1940288	1941679	D	synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA	1940288..1941679	Mycobacterium tuberculosis H37Rv	885086
NP_216230.1	CDS	Rv1714	NC_000962.2	1941853	1942665	D	Rv1714, (MTV048.01), len: 270 aa. Probable oxidoreductase (EC 1.-.-.-) similar to many e.g. AE0010|AE001021_4 Archaeoglobus fulgidus section 79 (281 aa), FASTA scores: opt: 578, E(): 3.3e-31, (38.9% identity in 265 aa overlap). Also similar to several other M. tuberculosis oxidoreductases e.g. Rv1544, etc.; oxidoreductase	1941853..1942665	Mycobacterium tuberculosis H37Rv	885159
YP_177829.1	CDS	fadB3	NC_000962.2	1942659	1943573	D	Rv1715, (MTV048.02), len: 304 aa. Probable fadB3, 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157), highly similar to many e.g. NP_107236.1|NC_002678 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti (309 aa); NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (509 aa); P45856|HBD_BACSU PROBABLE 3-HYDROXYBUTYRYL-COA DEHYDROGENASE from Bacillus subtilis (287 aa), FASTA scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa overlap); etc. COULD BELONG TO THE 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY.; 3-hydroxybutyryl-CoA dehydrogenase FADB3	1942659..1943573	Mycobacterium tuberculosis H37Rv	885160
NP_216232.1	CDS	Rv1716	NC_000962.2	1943576	1944406	D	Rv1716, (MTV048.03,MTCY04C12.01) len: 276 aa. Conserved hypothetical protein, shows high similarity with AF1200|O29068|AE001021_11A conserved protein of Archaeoglobus fulgidus, gp fulgidus section 7 (278 aa), FASTA scores: E(): 0, (61.8% identity in 251 a a overlap); also weak similarity to several polyketide cyclases e.g. O68500|AF048833|DPSY from Streptomyces peucetius (272 aa), FASTA scores: opt: 194, E(): 1.7e-05, (29.6% identity in 223 aa overlap).; hypothetical protein	1943576..1944406	Mycobacterium tuberculosis H37Rv	885162
NP_216233.1	CDS	Rv1717	NC_000962.2	1944406	1944756	D	Rv1717, (MTCY04C12.02), len: 116 aa. Conserved hypothetical protein, similar to O29060|AF1208|AE001021 Hypothetical protein from Arecheoglobus fulgidus (114 aa), FASTA scores: opt: 254, E(): 3.3e-09, (37.7% identity in 114 aa overlap).; hypothetical protein	1944406..1944756	Mycobacterium tuberculosis H37Rv	885166
NP_216234.1	CDS	Rv1718	NC_000962.2	1944809	1945627	D	Rv1718, (MTCY04C12.03), len: 272 aa. Conserved hypothetical protein, similar to O29058|AF1210|AE001021 Hypothetical protein from Archeoglobus (313 aa), FASTA scores: opt: 301, E(): 8e-23, (31.6% identity in 301 aa overlap).; hypothetical protein	1944809..1945627	Mycobacterium tuberculosis H37Rv	885169
NP_216235.1	CDS	Rv1719	NC_000962.2	1945641	1946420	D	Rv1719, (MTCY04C12.04), len: 259 aa. Probable transcriptional regulatory protein, similar to YIAJ_ECOLI|P37671 hypothetical transcriptional regulator from Escherichia coli (282 aa), FASTA scores: opt: 353, E(): 3.2e-15, (31.1% identity in 235 aa overlap). Similar to Mycobacterium tuberculosis hypothetical IclR-family transcriptional regulators Rv2989, Rv1773c. Helix-turn-helix motif from aa 34-55 (+6.94 SD).; transcriptional regulatory protein	1945641..1946420	Mycobacterium tuberculosis H37Rv	885170
NP_216236.1	CDS	Rv1720c	NC_000962.2	1947030	1947419	R	Rv1720c, (MTCY04C12.05c), len: 129 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O53610|Rv0065|MTV030.08 (133 aa), FASTA scores: E(): 1.5e-10, (39.1% identity in 128 aa overlap); P71550|Rv0960|MTCY10D7.14C (129 aa) and O06415|Rv0549c|MTCY25D10.28C (137 aa).; hypothetical protein	complement(1947030..1947419)	Mycobacterium tuberculosis H37Rv	885180
NP_216237.2	CDS	Rv1721c	NC_000962.2	1947416	1947643	R	Rv1721c, (MTCY04C12.06c), len: 75 aa. Conserved hypothetical protein, similar to Rv0300|MTCY63.05|O07227 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (73 aa). Start changed since original submission.; hypothetical protein	complement(1947416..1947643)	Mycobacterium tuberculosis H37Rv	885182
NP_216238.1	CDS	Rv1722	NC_000962.2	1947861	1949345	D	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; biotin carboxylase-like protein	1947861..1949345	Mycobacterium tuberculosis H37Rv	885183
NP_216239.1	CDS	Rv1723	NC_000962.2	1949342	1950589	D	Rv1723, (MTCY04C12.08), len: 415 aa. Possible hydrolase (EC 3.-.-.-), similar to others e.g. NYLB_FLASP|P07061 6-aminohexanoate-dimer hydrolase from Flavobacterium sp. (392 aa), FASTA scores: opt: 717, E(): 0, (35.1% identity in 396 aa overlap). Also similar to M. tuberculosis hypothetical esterases and penicillin binding proteins e.g. Rv1923, Rv1497, Rv2463, etc; hydrolase	1949342..1950589	Mycobacterium tuberculosis H37Rv	885185
NP_216240.1	CDS	Rv1724c	NC_000962.2	1950632	1951051	R	Rv1724c, (MTCY04C12.09c), len: 139 aa. Hypothetical unknown protein.; hypothetical protein	complement(1950632..1951051)	Mycobacterium tuberculosis H37Rv	885189
NP_216241.1	CDS	Rv1725c	NC_000962.2	1951041	1951751	R	Rv1725c, (MTCY04C12.10c), len: 236 aa. Conserved hypothetical protein, similar to other hypothetical proteins from diverse organisms e.g. P70885|U44893 ORF108 from BUTYRIVIBRIO FIBRISOLVENS, (108 aa), FASTA scores: opt: 223, E(): 2e-09, (39.1% identity in 92 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical transcriptional regulator, O05774|Rv3095|YU95_MYCTU (158 aa).; hypothetical protein	complement(1951041..1951751)	Mycobacterium tuberculosis H37Rv	885191
NP_216242.1	CDS	Rv1726	NC_000962.2	1951852	1953237	D	Rv1726, (MTCY04C12.11), len: 461 aa. Probable oxidoreductase (EC 1.-.-.-), similar to HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa), FASTA scores: opt: 678, E(): 0, (29.5% identity in 465 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical dehydrogenases e.g. Rv3107c, Rv1257c, etc.; oxidoreductase	1951852..1953237	Mycobacterium tuberculosis H37Rv	885192
NP_216243.1	CDS	Rv1727	NC_000962.2	1953270	1953839	D	Rv1727, (MTCY04C12.12), len: 189 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins P72040|Rv3773c|MTCY13D12.07C (194 aa), FASTA scores: opt: 176, E(): 2.7e-08, (31.1% identity in 180 aa overlap); and O53801|Rv0738 (182 aa).; hypothetical protein	1953270..1953839	Mycobacterium tuberculosis H37Rv	887422
NP_216244.1	CDS	Rv1728c	NC_000962.2	1953864	1954634	R	Rv1728c, (MTCY04C12.13c), len: 256 aa. Conserved hypothetical protein, some similarity to O07246|Rv0320|MTCY63.25 possible exported protein from Mycobacterium tuberculosis (220 aa), FASTA scores: E(): 1.3e-31, (42.3% identity in 220 aa overlap). C-terminal region similar to Q9ZX60|AF068845|AF068845_17 segment of gp17 of Mycobacteriophage TM4 (1229 aa), FASTA scores: opt: 385, E(): 4.3e-17, (44.6% identity in 139 aa overlap).; hypothetical protein	complement(1953864..1954634)	Mycobacterium tuberculosis H37Rv	885193
NP_216245.1	CDS	Rv1729c	NC_000962.2	1954631	1955569	R	Rv1729c, (MTCY04C12.14c), len: 312 aa. Conserved hypothetical protein, similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Q50726|Rv3399|YX99_MYCTU (348 aa), FASTA scores: opt: 1019, E(): 0, (55.7% identity in 296 aa overlap); P95074|Rv0726c (367 aa), O53795|Rv0731c (318 aa), and O53841|Rv0830 (301 aa), etc.; hypothetical protein	complement(1954631..1955569)	Mycobacterium tuberculosis H37Rv	885194
NP_216246.1	CDS	Rv1730c	NC_000962.2	1955692	1957245	R	Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643, E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923, Rv1497, etc.; penicillin-binding protein	complement(1955692..1957245)	Mycobacterium tuberculosis H37Rv	885202
NP_214748.2	CDS	gabD2	NC_000962.2	1957677	1959233	D	NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinic semialdehyde dehydrogenase	1957677..1959233	Mycobacterium tuberculosis H37Rv	885204
NP_216248.1	CDS	Rv1732c	NC_000962.2	1959243	1959791	R	Rv1732c, (MTCY04C12.17c), len: 182 aa. Conserved hypothetical protein, highly similar to hypothetical proteins from several organisms e.g. P73178|SLL1289|D90904 from Synechocystis (194 aa), FASTA scores: opt: 663, E(): 0, (53.1% identity in 179 aa overlap); etc.; hypothetical protein	complement(1959243..1959791)	Mycobacterium tuberculosis H37Rv	885211
NP_216249.1	CDS	Rv1733c	NC_000962.2	1959855	1960487	R	Rv1733c, (MTCY04C12.18c), len: 210 aa. Probable conserved transmembrane protein. Similar to AL109962|SCJ1_26 hypothetical protein from Streptomyces coelicolor (193 aa), FASTA scores: opt: 287, E(): 3.8e-11, (35.2% identity in 182 aa overlap).; transmembrane protein	complement(1959855..1960487)	Mycobacterium tuberculosis H37Rv	885214
NP_216250.1	CDS	Rv1734c	NC_000962.2	1960774	1961016	R	Rv1734c, (MTCY04C12.19c), len: 80 aa. Conserved hypothetical protein, similar to C-terminal region Q9Z8N2|CP0452|AE001615 Dihydrolipoamide Acetyltransferase from Chlamydia pneumoniae (429 aa), FASTA scores: opt: 138, E(): 0.0012, (26.9% identity in 78 aa overlap).; hypothetical protein	complement(1960774..1961016)	Mycobacterium tuberculosis H37Rv	885212
NP_216251.1	CDS	Rv1735c	NC_000962.2	1961291	1961788	R	Rv1735c, (MTCY04C12.20c), len: 165 aa. Hypothetical membrane protein, similar to part of O58614|PH0884|AP000004 Hypothetical malic acid transport protein from Pyrococcus horikoshii (330 aa), FASTA scores: opt: 167, E(): 0.0003, (29.2% identity in 120 aa overlap).; hypothetical protein	complement(1961291..1961788)	Mycobacterium tuberculosis H37Rv	885216
NP_216252.1	CDS	narX	NC_000962.2	1962228	1964186	R	Rv1736c, (MTCY04C12.21c), len: 652 aa. Probable narX, nitrate reductase (EC 1.7.99.4). Contains three domains: N-terminus (250 aa) is similar to e.g. N-terminus of NARG_ECOLI|P09152 respiratory nitrate reductase 1 alpha chain from Escherichia coli (1246 aa), FASTA scores: E(): 0, (58.6% identity in 251 aa overlap); and Rv1161|MTCI65.28|NARG PROBABLE RESPIRATORY NITRATE REDUCTASE (ALPHA CHAIN) from Mycobacterium tuberculosis (1232 aa). Central region (260-410 aa) is similar to Rv1163|O06561|NARJ PROBABLE RESPIRATORY NITRATE REDUCTASE (DELTA CHAIN) from Mycobacterium tuberculosis (201 aa), FASTA scores: E(): 0, (64.2% identity in 159 aa overlap). C-terminus (420 aa-) is similar to Rv1164|O06562|NARI PROBABLE RESPIRATORY NITRATE REDUCTASE (GAMMA CHAIN) from Mycobacterium tuberculosis (246 aa), FASTA scores: E(): 0, (68.6% identity in 239 aa overlap). Contains PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.; nitrate reductase NarX	complement(1962228..1964186)	Mycobacterium tuberculosis H37Rv	885213
NP_216253.1	CDS	narK2	NC_000962.2	1964183	1965370	R	Rv1737c, (MTCY04C12.22c), len: 395 aa. Possible narK2, nitrate/nitrite-transport integral membrane protein (see Hutter & Dick 2000), possibly member of major facilitator superfamily (MFS), similar to P46907|NARK_BACSU nitrite extrusion protein from Bacillus subtilis (395 aa), FASTA scores: opt: 742, E(): 0, (33.6% identity in 375 aa overlap); and to AL109989|SCJ12.23 hypothetical nitrate/nitrite transporter from Streptomyces coelicolor (412 aa), FASTA scores: opt: 1181, E(): 0, (49.4% identity in 389 aa overlap).; nitrate/nitrite transporter NarK2	complement(1964183..1965370)	Mycobacterium tuberculosis H37Rv	885231
NP_216254.1	CDS	Rv1738	NC_000962.2	1965657	1965941	D	Rv1738, (MTCY04C12.23), len: 94 aa. Conserved hypothetical protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kDa protein from Mycobacterium tuberculosis (93 aa), FASTA scores: opt: 319, E(): 2.6e-27, (53.9% identity in 89 aa overlap).; hypothetical protein	1965657..1965941	Mycobacterium tuberculosis H37Rv	885215
NP_216255.1	CDS	Rv1739c	NC_000962.2	1965955	1967637	R	Rv1739c, (MTCY04C12.24c, MTCY28.01), len: 560 aa. Probable sulphate-transport transmembrane protein ABC transporter, similar to several e.g. P53392|G607186 high affinity sulphate transporter from Stylosanthes hamata (662 aa), FASTA scores: opt: 382, E(): 1.6e-16, (28.0% identity in 564 aa overlap); U59234.1|AAB88215.1 biotin carb. from Synechococcus sp. PCC 7942 (574 aa), FASTA scores: opt: 1838, E(): 0, (50.0% identity in 550 aa overlap); etc. Contains PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS), AND SEEMS TO BELONG TO THE SULP FAMILY.; sulphate-transport transmembrane protein ABC transporter	complement(1965955..1967637)	Mycobacterium tuberculosis H37Rv	887208
NP_216256.1	CDS	Rv1740	NC_000962.2	1967705	1967917	D	Rv1740, (MTCY28.02-MTCY04C12.25), len: 70 aa. Conserved hypothetical protein, highly similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P96913|Rv0623|MTCY20H10.04 (84 aa), (73.5% identity in 68 aa overlap); P71998|Rv1740 (70 aa), and O07770|Rv0608 (81 aa).; hypothetical protein	1967705..1967917	Mycobacterium tuberculosis H37Rv	885226
NP_216257.1	CDS	Rv1741	NC_000962.2	1967917	1968165	D	Rv1741, (MTCY28.03,MTCY04C12.26), len: 82 aa. Conserved hypothetical protein, very similar in N-terminus to other Mycobacterium tuberculosis hypothetical proteins e.g. P96914|Rv0624|MTCY20H10.05 (131 aa), (80.4% identity in 56 aa overlap); P71999|Rv1741 (82 aa) and O07769|Rv0609 (133 aa).; hypothetical protein	1967917..1968165	Mycobacterium tuberculosis H37Rv	887165
NP_216258.1	CDS	Rv1742	NC_000962.2	1968173	1968910	D	Rv1742, (MTCY28.04,MTCY04C12.27), len: 245 aa. Hypothetical unknown protein.; hypothetical protein	1968173..1968910	Mycobacterium tuberculosis H37Rv	885234
NP_216259.1	CDS	pknE	NC_000962.2	1969004	1970704	D	Rv1743, (MTCY28.05,MTCY04C12.28), len: 566 aa. Probable pknE, transmembrane serine/threonine protein kinase (EC 2.7.1.-) (see citation below), similar to PKN1_MYXXA|P33973 serine/threonine-protein kinase pkn1 (693 aa), fasta scores: opt: 542, E(): 1.1e-19, (35.8% identity in 302 aa overlap). Also highly similar to K08G_MYCTU|Q11053 probable serine/threonine-protein kinase (626 aa) (59.8% identity in 381 aa overlap). Contains PS00107 Protein kinases ATP-binding region signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.; transmembrane serine/threonine-protein kinase E	1969004..1970704	Mycobacterium tuberculosis H37Rv	885284
NP_216260.1	CDS	Rv1744c	NC_000962.2	1970989	1971390	R	Rv1744c, (MTCY28.06c), len: 133 aa. Probable membrane protein, contains four imperfect 10 aa repeats, some similarity to Q25946 (MSA-2) (FRAGMENT) from Plasmodium falciparum (205 aa), FASTA scores: opt: 145, E( ): 0.048, (52.4% identity in 63 aa overlap).; hypothetical protein	complement(1970989..1971390)	Mycobacterium tuberculosis H37Rv	885235
NP_216261.1	CDS	idi	NC_000962.2	1971380	1971991	R	catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase	complement(1971380..1971991)	Mycobacterium tuberculosis H37Rv	885309
NP_216262.1	CDS	pknF	NC_000962.2	1972138	1973568	D	Rv1746, (MTCY28.09, MTCY04C12.30), len: 476 aa. pknF, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citations below), highly similar to KY28_MYCTU|Q10697 probable serine/threonine-protein kinase from Mycobacterium tuberculosis (589 aa), FASTA scores: opt: 870, E(): 0, (41.6% identity in 406 aa overlap). Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation. Start site chosen by homology, may extend further upstream.; anchored-membrane serine/threonine-protein kinase PKNF (protein kinase F) (STPK F)	1972138..1973568	Mycobacterium tuberculosis H37Rv	885275
NP_216263.1	CDS	Rv1747	NC_000962.2	1973630	1976227	D	Rv1747, (MTCY28.10, MTCY04C12.31), len: 865 aa. Probable conserved transmembrane ATP-binding protein ABC transporter (see citation below), similar to others e.g Q55956 ABC transporter from Synechocystis sp. (790 aa), FASTA scores: opt: 738, E(): 6.3e-26, (31.6% identity in 632 aa overlap); etc. Also similar to other M. tuberculosis ABC-type transporters e.g. Rv2397c|MTCY253.24, FASTA score: (35.2% identity in 213 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; transmembrane ATP-binding protein ABC transporter	1973630..1976227	Mycobacterium tuberculosis H37Rv	885311
NP_216264.1	CDS	Rv1748	NC_000962.2	1976600	1977331	D	Rv1748, (MTCY28.11, MTCY04C12.32), len: 243 aa. Hypothetical unknown protein. Possibly exported protein, hydrophobic domain, TM helix aa 23-45.; hypothetical protein	1976600..1977331	Mycobacterium tuberculosis H37Rv	885288
NP_216265.1	CDS	Rv1749c	NC_000962.2	1977328	1977885	R	Rv1749c, (MTCY28.12c-MTCY04C12.33c), len: 185 aa. Possible integral membrane protein, similar to O27914|AE000940 hypothetical protein MTH1892 from Methanobacterium thermoautotrophicum (168 aa), fasta scores: E(): 9.3e-16, (37.4% identity in 123 aa overlap).; integral membrane protein	complement(1977328..1977885)	Mycobacterium tuberculosis H37Rv	885322
NP_216266.1	CDS	fadD1	NC_000962.2	1977969	1979567	R	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	complement(1977969..1979567)	Mycobacterium tuberculosis H37Rv	885310
NP_216267.1	CDS	Rv1751	NC_000962.2	1979621	1981003	D	Rv1751, (MTCY28.14-MTCY04C12.35), len: 460 aa. Probable oxidoreductase (EC 1.-.-.-), possibly a monooxygenase or hydroxylase, similar to MHPA_ECOLI|P77397 3-(3-hydroxy-phenyl) propionate hydroxylase (554 aa), FASTA scores: opt: 239, E(): 2e-08, (24.6% identity in 435 aa overlap); and AJ007932|SAR7932.13 oxygenase from Streptomyces argillaceus (436 aa), FASTA scores: opt: 587, E(): 8.6e-30, (32.3% identity in 359 aa overlap). Contains PS00075 Dihydrofolate reductase signature. Also similar to Mycobacterium tuberculosis hypothetical oxidoreductases Rv1260 and Rv0575c.; hypothetical protein	1979621..1981003	Mycobacterium tuberculosis H37Rv	885489
NP_216268.1	CDS	Rv1752	NC_000962.2	1981130	1981579	D	Rv1752, (MTCY28.15), len: 149 aa. Conserved hypothetical protein, similar to C-terminal half of Q9TV68|AB021930|CAN2DD Dihydrodiol dehydrogenase (EC 1.3.1.20) from Canis familiaris (335 aa), FASTA score, opt: 168, E(): 0.00015, (31.3% identity in 112 aa overlap).; hypothetical protein	1981130..1981579	Mycobacterium tuberculosis H37Rv	885313
YP_177830.1	CDS	PPE24	NC_000962.2	1981614	1984775	R	Rv1753c, (MTCY28.16c), len: 1053 aa. Member of the Mycobacterium tuberculosis PPE family of Gly-, Asn-rich proteins, similar to many e.g. YF48_MYCTU|Q10778 hypothetical protein cy48.17 (678 aa), FASTA scores: opt: 1360, E(): 0, (48.9% identity in 550 aa overlap). Note that the Gly-, Asn-rich sequence is interrupted by six near-perfect 26 aa repeats, a unique region, and another, more degenerate region of five 25 aa repeats before resuming at the C-terminus. The end of the first Gly-, Asn- rich region and the start of the first set of repeats shows some similarity to Q50577|AT10S from Mycobacterium tuberculosis (170 aa) (40.2% identity in 189 aa overlap).; PPE family protein	complement(1981614..1984775)	Mycobacterium tuberculosis H37Rv	885544
NP_216270.1	CDS	Rv1754c	NC_000962.2	1984979	1986670	R	Rv1754c, (MTCY28.17c), len: 563 aa. Conserved hypothetical protein, has proline-rich central region. Some similarity in central region to other Mycobacterium tuberculosis proline-rich proteins e.g. O06555|Rv1157c|MTCI65.24c (371 aa), (32.5% identity in 191 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	complement(1984979..1986670)	Mycobacterium tuberculosis H37Rv	885467
NP_216271.1	CDS	plcD	NC_000962.2	1986854	>1987696	R	Rv1755c, (MT1799, MTCY28.21c), len: 280 aa. Probable plcD, phospholipase C 4 (fragment) (EC 3.1.4.3) (see citations below), highly similar to C-terminus of other phospholipases e.g. CQ50771|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase C 1 from Mycobacterium tuberculosis (512 aa), FASTA score: (71.1% identity in 284 aa overlap); etc. Note that this ORF has been interrupted by insertion of IS6110 element. BELONGS TO THE BACTERIAL PHOSPHOLIPASE C FAMILY.; phospholipase C 4 PLCD	complement(1986854..>1987696)	Mycobacterium tuberculosis H37Rv	885566
NP_216272.1	CDS	Rv1756c	NC_000962.2	1987745	1988629	R	Rv1756c, (MTCY28.22c), len: 294 aa. Putative Transposase subunit for IS6110.; putative transposase	complement(1987745..1988629)	Mycobacterium tuberculosis H37Rv	885541
NP_216273.1	CDS	Rv1757c	NC_000962.2	1988680	1989006	R	Rv1757c, (MTCY28.23c), len: 108 aa. Putative Transposase subunit for IS6110; putative transposase	complement(1988680..1989006)	Mycobacterium tuberculosis H37Rv	885558
NP_216274.1	CDS	cut1	NC_000962.2	1989042	1989566	D	Rv1758, (MTCY28.24), len: 174 aa. Probable cut1, serine esterase, cutinase family (EC 3.1.1.-), similar to Rv2301|CUT2_MYCTU|Q50664 probable cutinase cy339.08c precursor from Mycobacterium tuberculosis (219 aa), FASTA scores: opt: 369, E(): 1. 1e-16, (39.1% identity in 179 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical cutinases Rv3452, Rv1984c, Rv3451 and Rv3724. CDS has been interrupted by IS6110 insertion element and 5'-end deleted. BELONGS TO THE CUTINASE FAMILY.; cutinase Cut1	1989042..1989566	Mycobacterium tuberculosis H37Rv	885552
YP_177831.1	CDS	wag22	NC_000962.2	1989833	1992577	R	Rv1759c, (MT1807, MTCY28.25c), len: 914 aa. wag22, antigen member (see citations below) of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, highly similar to others e.g. MT1367|Q10637 hypothetical glycine-rich 49.6 kDa protein from Mycobacterium tuberculosis (603 aa), FASTA scores: opt: 2010, E(): 0, (53.0% identity in 724 aa overlap); etc.; PE-PGRS family protein	complement(1989833..1992577)	Mycobacterium tuberculosis H37Rv	885325
NP_216276.1	CDS	Rv1760	NC_000962.2	1993153	1994661	D	Rv1760, (MTCY28.26), len: 502 aa. Conserved hypothetical protein, similar to several other Mycobacterium tuberculosis hypothetical proteins e.g. Q10554|Y895_MYCTU|MTCY31.23 (505 aa), FASTA scores: opt: 692, E(): 0, (31.7% identity in 477 aa overlap). Member of family with at least 15 other members e.g. Rv3740c, Rv3734c, Rv1425, etc.; hypothetical protein	1993153..1994661	Mycobacterium tuberculosis H37Rv	885556
NP_216277.1	CDS	Rv1761c	NC_000962.2	1994671	1995054	R	Rv1761c, (MTCY28.27c), len: 127 aa. Possibly exported protein with hydrophobic stretch or TMhelix at aa 15-37.; hypothetical protein	complement(1994671..1995054)	Mycobacterium tuberculosis H37Rv	885436
NP_216278.1	CDS	Rv1762c	NC_000962.2	1995054	1995842	R	Rv1762c, (MTCY28.28c), len: 262 aa. Hypothetical unknown protein.; hypothetical protein	complement(1995054..1995842)	Mycobacterium tuberculosis H37Rv	885373
NP_216279.1	CDS	Rv1763	NC_000962.2	1996152	1996478	D	Rv1763, (MTCY28.29), len: 108 aa. Putative Transposase for IS6110 insertion element; putative transposase	1996152..1996478	Mycobacterium tuberculosis H37Rv	885372
NP_216280.1	CDS	Rv1764	NC_000962.2	1996529	1997413	D	Rv1764, (MTCY28.30), len: 294 aa. Putative Transposase for IS6110 insertion element; putative transposase	1996529..1997413	Mycobacterium tuberculosis H37Rv	885238
NP_216281.1	CDS	Rv1765c	NC_000962.2	1997418	1998515	R	Rv1765c, (MTCY28.31c), len: 365 aa. Conserved hypothetical protein, highly similar to O53461|Rv2015c|MTV018.02c CONSERVED HYPOTHETICAL PROTEIN (418 aa), (97.8% identity in 364 aa overlap). BLAST hits with non-IS part of sequence submitted under MTU78639.; hypothetical protein	complement(1997418..1998515)	Mycobacterium tuberculosis H37Rv	885256
YP_177652.1	CDS	Rv1765A	NC_000962.2	1999142	1999357	R	Rv1765A, len: 71 aa. Putative transposase (fragment), similar to part of many transposase genes including IS6110 e.g. P19774|TRA9_MYCTU PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis (278 aa), FASTA scores: opt: 231, E(): 4.7e-11, (45.35% identity in 75 aa overlap).; transposase	complement(1999142..1999357)	Mycobacterium tuberculosis H37Rv	3205098
NP_216282.2	CDS	Rv1766	NC_000962.2	1999737	2000006	D	Rv1766, (MTCY28.32), len: 89 aa. Conserved hypothetical protein, highly similar to P54431|YRKD_BACSU Hypothetical 7.0 kDa protein in bltr-spoIIIC intergenic region from Bacillus subtilis (63 aa), FASTA scores: opt: 151, E(): 1.5e-05, (53.3% identity in 45 aa overlap). Also similar to Q9RD62|SCF56.04C|AL133424 Hypothetical protein from Streptomyces coelicolor (92 aa), FASTA scores: opt: 239, E(): 1.3e-11, (62.5% identity in 64 aa overlap). Also some similarity to other Mycobacterium tuberculosis hypothetical proteins e.g. O07434|Rv0190|MTCI28.29 (96 aa), (35.5% identity in 62 aa overlap); P71543|Rv0967 (119 aa), and P71600|Rv0030 (109 aa). Start changed since original submission.; hypothetical protein	1999737..2000006	Mycobacterium tuberculosis H37Rv	885427
NP_216283.1	CDS	Rv1767	NC_000962.2	2000074	2000433	D	Rv1767, (MTCY28.33), len: 119 aa. Conserved hypothetical protein, similar to Q57498|YA53_HAEIN HYPOTHETICAL PROTEIN HI1053 from Haemophilus influenzae (113 aa), FASTA scores: opt: 233, E(): 6.4e-10, (40.0% identity in 90 aa overlap).; hypothetical protein	2000074..2000433	Mycobacterium tuberculosis H37Rv	885443
YP_177832.1	CDS	PE_PGRS31	NC_000962.2	2000614	2002470	D	Rv1768, (MTCY28.34), len: 618 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to Q50615 HYPOTHETICAL 40.8 kDa PROTEIN (498 aa), FASTA scores: opt: 1703, E(): 0, (57.4% identity in 566 aa overlap).; PE-PGRS family protein	2000614..2002470	Mycobacterium tuberculosis H37Rv	885429
NP_216285.1	CDS	Rv1769	NC_000962.2	2002626	2003870	D	Rv1769, (MTCY28.35), len: 414 aa. Conserved hypothetical protein, similar to O88066|SCI35.31|AL031541 hypothetical protein from Streptomyces coelicolor (402 aa), FASTA scores: opt: 1341, E(): 0, (53.8% identity in 398 aa overlap).; hypothetical protein	2002626..2003870	Mycobacterium tuberculosis H37Rv	885420
NP_216286.1	CDS	Rv1770	NC_000962.2	2003878	2005164	D	Rv1770, (MTCY28.36), len: 428 aa. Conserved hypothetical protein, highly similar in N-terminus to Q49882 Hypothetical protein from Mycobacterium leprae from cosmid L247 (83 aa), FASTA scores: opt: 301, E(): 1e-12, (56.5% identity in 85 aa overlap).; hypothetical protein	2003878..2005164	Mycobacterium tuberculosis H37Rv	885415
NP_216287.1	CDS	Rv1771	NC_000962.2	2005161	2006447	D	Rv1771, (MTCY28.37), len: 428 aa. Probable oxidoreductase (EC 1.-.-.-), similar to e.g. GGLO_RAT|P10867 l-gulonolactone oxidase (ec 1.1.3.8) (439 aa), FASTA scores: opt: 862, E(): 0, (34.1% identity in 434 aa overlap). Also shows slight similarity to Mycobacterium tuberculosis oxidoreductase Rv1726|MTCY04C12.11 (22.9% identity in 441 aa overlap) and others e.g. Rv3107c, Rv1257c, Rv2251, etc. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site.; oxidoreductase	2005161..2006447	Mycobacterium tuberculosis H37Rv	885441
NP_216288.1	CDS	Rv1772	NC_000962.2	2006636	2006947	D	Rv1772, (MTCY28.38), len: 103 aa. Hypothetical unknown protein.; hypothetical protein	2006636..2006947	Mycobacterium tuberculosis H37Rv	885920
NP_216289.1	CDS	Rv1773c	NC_000962.2	2007020	2007766	R	Rv1773c, (MTCY28.39), len: 248 aa. Probable transcriptional regulator belonging to IclR family, similar to ICLR_ECOLI|P16528 acetate operon repressor from Escherichia coli (274 aa), FASTA scores: opt: 261, E(): 3.3e-10, (26.9% identity in 249 aa overlap). Also similar to Mycobacterium tuberculosis protein Rv1719|MTCY04C12.04 (40.2% identity in 244 aa overlap); and Rv2989. Start site chosen by homology, but may extend further upstream. Contains possible helix-turn-helix motif at aa 37-58 (+3.24 SD).; transcriptional regulatory protein	complement(2007020..2007766)	Mycobacterium tuberculosis H37Rv	885342
NP_216290.1	CDS	Rv1774	NC_000962.2	2007832	2009172	D	Rv1774, (MTCY25C11.01), len : 446 aa. Probable oxidoreductase (EC 1.-.-.-), similar to several e.g. HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa), FASTA scores: opt: 417, E(): 6e-20, (28.4% identity in 462 aa overlap). Also some similarity to Mycobacterium tuberculosis oxidoreductase MTCY04C12.11 (24.1% identity in 444 aa overlap). Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site.; oxidoreductase	2007832..2009172	Mycobacterium tuberculosis H37Rv	885367
NP_216291.1	CDS	Rv1775	NC_000962.2	2009172	2009990	D	Rv1775, (MTCY25C11.02), unknown, len: 272 aa. Conserved hypothetical protein, similar to O28806|AF1466 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (255 aa), FASTA scores: opt: 364, E(): 1e-17, (29.2% identity in 267 aa overlap).; hypothetical protein	2009172..2009990	Mycobacterium tuberculosis H37Rv	885842
NP_216292.1	CDS	Rv1776c	NC_000962.2	2009995	2010555	R	Rv1776c, (MTCY25C11.03c), len: 186 aa. Possible regulatory protein, some similarity to Mycobacterium tuberculosis Rv1255c|Q11063 hypothetical transcriptional regulator (202 aa), FASTA scores: opt: 270, E( ): 9.7e-09, (28.3% identity in 191 aa overlap) . Contains possible helix-turn-helix motif at aa 37-58 (+3.49 SD).; transcriptional regulatory protein	complement(2009995..2010555)	Mycobacterium tuberculosis H37Rv	885821
NP_216293.1	CDS	cyp144	NC_000962.2	2010656	2011960	D	Rv1777, (MT1827, MTCY25C11.04), len: 434 aa. Probable cyp144, cytochrome p450 (EC 1.14.-.-), similar to CPXM_BACME|Q06069 cytochrome p450 (meg) (EC 1.14.99.-) (410 aa), FASTA scores: opt: 435 E(): 2.3e-16, (28.8% identity in 372 aa overlap). Also similar to several other Mycobacterium tuberculosis p450 genes including Rv0766c, Rv2266, etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.; cytochrome p450 144 CYP144	2010656..2011960	Mycobacterium tuberculosis H37Rv	885839
NP_216294.1	CDS	Rv1778c	NC_000962.2	2012081	2012530	R	Rv1778c, (MTCY25C11.05c), len: 149 aa. Hypothetical unknown protein.; hypothetical protein	complement(2012081..2012530)	Mycobacterium tuberculosis H37Rv	885424
NP_216295.1	CDS	Rv1779c	NC_000962.2	2012686	2014479	R	Rv1779c, (MTV049.01c), len: 597. Possible integral membrane protein. TBparse score is 0.913.; integral membrane protein	complement(2012686..2014479)	Mycobacterium tuberculosis H37Rv	885829
NP_216296.1	CDS	Rv1780	NC_000962.2	2014699	2015262	D	Rv1780, (MTV049.02), len: 187 aa. Conserved hypothetical protein, equivalent to Q49881|ML1380|U00021_2 cosmid L247 from Mycobacterium leprae (187 aa), FASTA scores: opt: 1000, E(): 0, (82.4% identity in 187 aa overlap). TBparse score is 0.930; hypothetical protein	2014699..2015262	Mycobacterium tuberculosis H37Rv	885851
NP_216297.1	CDS	malQ	NC_000962.2	2015302	2017476	R	Rv1781c, (MTV049.03c), len: 724 aa. Probable malQ, 4-ALPHA-GLUCANOTRANSFERASE (EC 2.4.1.25), similar to many, e.g. P15977|MALQ_ECOLI 4-ALPHA-GLUCANOTRANSFERASE (694 aa), FASTA scores: opt: 964, E(): 0, (31.8% identity in 694 aa overlap). BELONGS TO THE DISPROPORTIONATING ENZYME FAMILY.; 4-alpha-glucanotransferase MalQ	complement(2015302..2017476)	Mycobacterium tuberculosis H37Rv	885854
NP_216298.1	CDS	Rv1782	NC_000962.2	2017740	2019260	D	Rv1782, (MTV049.04), len: 506 aa. Probable conserved membrane protein, similar to four other Mycobacterium tuberculosis hypothetical membrane proteins e.g. O05449|Rv3895c|MTCY15F10.17|Z94121 (495 aa), FASTA scores: opt: 1106, E(): 0, (41.2% identity in 485 aa overlap); Rv0283, Rv3450c, and Rv3869, all located near ESAT-6 family genes. Also similar to O33088|MLCB628.17C|Y14967 cosmid B628 from Mycobacterium leprae (481 aa), (32.7% identity in 486 aa overlap); and equivalent to Q9Z5I3|MLCB596.27|AL035472 hypothetical protein from Mycobacterium leprae (506 aa) (82.6% identity in 506 aa overlap). Has hydrophobic stretch from aa 54-76.; hypothetical protein	2017740..2019260	Mycobacterium tuberculosis H37Rv	885347
NP_216299.1	CDS	Rv1783	NC_000962.2	2019257	2020564	D	Rv1783, (MTV049.05), len: 435 aa. Probable conserved membrane protein. Member of family of Mycobacterium tuberculosis hypothetical proteins including O05450|Rv3894c|MTY15F10.18|Z94121 (1396 aa), FASTA scores: opt: 542, E(): 1.5e-26, (31.4% identity in 440 aa overlap); Rv3447c, Rv0284, Rv3870, Rv1784, and Rv3871, all linked to ESAT-6 family gene. Similar to N-terminal part of Rv3894c (1396 aa), Rv1784 is similar to remainder of Rv3894c. Also similar to O33087|MLCB628.16C|Y14967 Hypothetical protein from Mycobacterium leprae (744 aa), (30.0% identity in 437 aa overlap) and equivalent to N-terminal part of Q9Z5I2|MLCB596.28|AL035472 hypothetical protein from Mycobacterium leprae (1345 aa), (86.4% identity in 397 aa overlap).; hypothetical protein	2019257..2020564	Mycobacterium tuberculosis H37Rv	885898
NP_216300.1	CDS	Rv1784	NC_000962.2	2020634	2023432	D	Rv1784, (MTV049.06), len: 932 aa. Conserved hypothetical protein, member of family of Mycobacterium tuberculosis hypothetical proteins including Rv3447c, Rv0284, Rv3870, Rv1783, Rv3871, Rv3894c, all linked to ESAT-6 family genes. Probably ATP-binding membrane proteins. Similar to C-terminal region of 006264|Rv3447c (1236 aa), (36.2% identity in 930 aa overlap). Equivalent to C-terminal region of Mycobacterium leprae hypothetical protein Q9Z512|MLCB596.28|AL035472 (1345 aa), (87.8% identity in 932 aa overlap); also similar to other hypothetical proteins e.g. MLCB628.14 from Mycobacterium leprae, (32.0% identity in 600 aa overlap); MLCB628.15 from Mycobacterium leprae, (35.0% identity in 280 aa overlap); and O86653|SC3C3.20|AL031231 ATP/GTP binding protein from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 618, E(): 4.6e-30, (34.3% identity in 937 aa overlap). Contains two times PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	2020634..2023432	Mycobacterium tuberculosis H37Rv	885834
NP_216301.1	CDS	cyp143	NC_000962.2	2023447	2024628	R	Rv1785c, (MT1834, MTV049.07c), len: 393 aa. Probable cyp143, cytochrome P450 (1.14.-.-), similar to many e.g. AE0001|RZAE000101_4 Rhizobium sp. NGR234 (414 aa), FASTA scores: opt: 663, E(): 0, (32.4% identity in 413 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.; cytochrome P450 143	complement(2023447..2024628)	Mycobacterium tuberculosis H37Rv	885907
NP_216302.1	CDS	Rv1786	NC_000962.2	2024828	2025031	D	Rv1786, (MTV049.08), len: 67 aa. Probable ferredoxin (EC 1.-.-.-), similar to others e.g. X63601|FERS_STRGR FERREDOXIN from Streptomyces griseus (65 aa), FASTA scores: opt: 140, E(): 0.001, (38.1% identity in 63 aa overlap); T50943 probable ferredoxin DitA from Pseudomonas abietaniphila (78 aa); BAA84714.1|AB017795 ferredoxin from Nocardioides sp. (69 aa); etc. Also similar to Rv0763c|MTCY369.08 from Mycobacterium tuberculosis (68 aa), FASTA score: (30.6% identity in 62 aa overlap); and Rv0763c.; ferredoxin	2024828..2025031	Mycobacterium tuberculosis H37Rv	885846
YP_177833.1	CDS	PPE25	NC_000962.2	2025301	2026398	D	Rv1787, (MTV049.09), len: 365 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to Z74024|MTCY274.24 Mycobacterium tuberculosis cosmid (404 aa), FASTA scores: opt: 837, E(): 0, (52.0% identity in 406 aa overlap).; PPE family protein	2025301..2026398	Mycobacterium tuberculosis H37Rv	885827
YP_177834.1	CDS	PE18	NC_000962.2	2026477	2026776	D	Rv1788, (MTV049.10), len: 99 aa. Member of the Mycobacterium tuberculosis PE family of gly-, ala-rich proteins (see citation below), similar to Z93777|MTCI364.07 Mycobacterium tuberculosis cosmid (99 aa), FASTA scores: opt: 414, E(): 3.6e-20, (72.4% identity in 98 aa overlap).; PE family protein	2026477..2026776	Mycobacterium tuberculosis H37Rv	885895
YP_177835.1	CDS	PPE26	NC_000962.2	2026790	2027971	D	Rv1789, (MTV049.11), len: 393 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to others e.g.Z98268|MTCI125.26 Mycobacterium tuberculosis cosmid (385 aa), FASTA score: opt: 1283, E(): 0, (62.7% identity in 408 aa overlap).; PPE family protein	2026790..2027971	Mycobacterium tuberculosis H37Rv	885333
YP_177836.1	CDS	PPE27	NC_000962.2	2028425	2029477	D	Rv1790, (MTV049.12), len: 350 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich protein, similar to Z74024|MTCY274.24 Mycobacterium tuberculosis cosmid (404 aa), FASTA scores: opt: 849, E(): 0, (50.0% identity in 406 aa overlap).; PPE family protein	2028425..2029477	Mycobacterium tuberculosis H37Rv	885859
YP_177837.1	CDS	PE19	NC_000962.2	2029904	2030203	D	Rv1791, (MTV049.13), len: 99 aa. Member of the Mycobacterium tuberculosis PE family, but no glycine rich C-terminus (see Brennan & Delogu 2002), highly similar to Z93777|MTCI364.07 M.tuberculosis cosmid (99 aa) opt: 430 E(): 2.4e-21, (75.5% identity in 98 aa overlap).; PE family protein	2029904..2030203	Mycobacterium tuberculosis H37Rv	885445
YP_177838.1	CDS	esxN	NC_000962.2	2030694	2030978	D	Rv1793, (MT1842, MTV049.15), len: 94 aa. esxN, ESAT-6 like protein (see citation below), almost identical to several mycobacterial proteins of the ESAT-6-like family including P95242|Rv2346c|MTCY98.15C|Z83860 PUTATIVE ESAT-6 LIKE PROTEIN 6 (94 aa), FASTA scores: opt: 610, E(): 0, (97.9 % identity in 94 aa overlap); Rv3619c, Rv1037c, and Rv1198, etc. Also present in Mycobacterium leprae. SEEMS TO BELONG TO THE ESAT6 FAMILY.; ES6_5, Mtb9.9A; putative ESAT-6 like protein ESXN (ESAT-6 like protein 5)	2030694..2030978	Mycobacterium tuberculosis H37Rv	885448
NP_216310.1	CDS	Rv1794	NC_000962.2	2031066	2031968	D	Rv1794, (MTV049.16), len: 300 aa. Conserved hypothetical protein, slight similarity to Mycobacterium tuberculosis O53694|Rv0289|MTV035.17, (295 aa), FASTA scores: opt: 172, E(): 0.00083, (25.7% identity in 261 aa overlap). Equivalent to Mycobacterium leprae hypothetical protein Q9Z5I1|MLCB596.31|AL035472 (300 aa), (88.0% identity in 300 aa overlap). Contains PS00211 ABC transporters family signature. TBparse score is 0.926.; hypothetical protein	2031066..2031968	Mycobacterium tuberculosis H37Rv	885881
NP_216311.1	CDS	Rv1795	NC_000962.2	2032240	2033751	D	Rv1795, (MTV049.17), len: 503 aa. Conserved hypothetical membrane protein, has a hydrophilic stretch from 1-130 then very hydrophobic. Similar to several other mycobacterial proteins, all linked to ESAT-6 family e.g. Rv3887c|MTY15F10.24|Z94121 (509 aa), FASTA scores: opt: 360, E(): 1.6e-15, (26.7% identity in 514 aa overlap); Rv3448, and Rv0290. TBparse score is 0.916.; hypothetical protein	2032240..2033751	Mycobacterium tuberculosis H37Rv	885628
NP_216312.1	CDS	mycP5	NC_000962.2	2033729	2035486	D	Rv1796, (MTV049.18), len: 585 aa. Probable mycP5, pro-rich membrane-anchored serine protease (mycosin) (EC 3.4.21.-) (see citations below). Member of family with four other Mycobacterium tuberculosis serine proteases: Rv3886c|O05458|MTCY15F10.26|Z94121 (550 aa), FASTA scores: opt: 1173, E(): 0, (47.9% identity in 578 aa overlap); Rv0291, Rv3883c, and Rv3449. Genes all linked to those of ESAT-6 family. Has possible N-terminal signal peptide and hydrophobic anchor-like stretch at C-terminus. Contains two serine protease, subtilase family active site motifs: a aspartic acid active site motif (PS00136); and a histidine active site motif (PS00137). BELONGS TO PEPTIDASE FAMILY S8 (ALSO KNOWN AS THE SUBTILASE FAMILY), PYROLYSIN SUBFAMILY. TBparse score is 0.930.; proline rich membrane-anchored mycosin MYCP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	2033729..2035486	Mycobacterium tuberculosis H37Rv	885879
NP_216313.1	CDS	Rv1797	NC_000962.2	2035483	2036703	D	Rv1797, (MTV049.19), len: 406 aa. Conserved hypothetical protein, some similarity to Mycobacterium tuberculosis O05462|Rv3882c|MTCY15F10.30|Z94121 (462 aa), FASTA scores: opt: 181, E(): 9.2e-05, (25.4% identity in 283 aa overlap). Has hydrophobic stretch near N-terminus. TBparse score is 0.938; hypothetical protein	2035483..2036703	Mycobacterium tuberculosis H37Rv	885452
NP_216314.1	CDS	Rv1798	NC_000962.2	2036700	2038532	D	Rv1798, (MTV049.20), len: 610 aa. Conserved hypothetical protein, similar to several mycobacterial proteins e.g. O05460|MTCY15F10.28|Rv3884c|Z94121 from M. tuberculosis (619 aa), FASTA scores: opt: 669, E(): 0, (31.0% identity in 549 aa overlap); and O33089|MLCB628.18c|Y14967 from Mycobacterium leprae (573 aa), FASTA scores: opt: 723, E(): 0, (32.4% identity in 568 aa overlap). Also very similar to Rv0282. May belong to the CBXX/CFQX family as last 320 aa domain very similar to several family members. Contains ATP/GTP-binding site motif A (P-loop; PS00017). TBparse score is 0.903; hypothetical protein	2036700..2038532	Mycobacterium tuberculosis H37Rv	885543
NP_216315.1	CDS	lppT	NC_000962.2	2039159	2039350	D	Rv1799, (MTV049.21), len: 63. Probable lppT lipoprotein, has possible signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.904; lipoprotein LppT	2039159..2039350	Mycobacterium tuberculosis H37Rv	885901
YP_177839.1	CDS	PPE28	NC_000962.2	2039453	2041420	D	Rv1800, (MTV049.22), len: 655 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, C-terminal very similar to parts of PE proteins e.g. Z92770|MTCI5.25|Rv0151c (588 aa), FASTA scores: opt: 1269, E(): 0, (41.5% identity in 591 aa overlap). TBparse score is 0.925; PPE family protein	2039453..2041420	Mycobacterium tuberculosis H37Rv	885465
YP_177840.1	CDS	PPE29	NC_000962.2	2042001	2043272	D	Rv1801, (MTV049.23), len: 423 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to AL022021|MTV049.29|Rv1808 (409 aa), FASTA scores: opt: 1229, E(): 0, (55.2% identity in 422 aa overlap). TBparse score is 0.927.; PPE family protein	2042001..2043272	Mycobacterium tuberculosis H37Rv	885491
YP_177841.1	CDS	PPE30	NC_000962.2	2043384	2044775	D	Rv1802, (MTV049.24), len: 463 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to AL022021|MTV049.30|Rv1809 (468 aa), FASTA scores: opt: 1238, E(): 0, (51.0% identity in 471 aa overlap). TBparse score is 0.913.; PPE family protein	2043384..2044775	Mycobacterium tuberculosis H37Rv	885542
YP_177842.1	CDS	PE_PGRS32	NC_000962.2	2044923	2046842	R	Rv1803c, (MTV049.25c), len: 639 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Most similar to Rv1768|MTCY28.34|Z95890 (618 aa), FASTA scores: opt: 1827, E(): 0, (53.5% identity in 664 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. TBparse score is 0.912.; PE-PGRS family protein	complement(2044923..2046842)	Mycobacterium tuberculosis H37Rv	885730
NP_216320.1	CDS	Rv1804c	NC_000962.2	2047023	2047349	R	Rv1804c, (MTV049.26c), len: 108 aa. Conserved hypothetical protein, similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (hydrophobic stretch at N-terminus) e.g. O07222|Rv1810|MTCY16F9.04C|Z96073 (118 aa), FASTA scores: opt: 361, E(): 2.3e-19, (53.5% identity in 101 aa overlap); Rv0622, Rv1690, and Rv3067, etc. TBparse score is 0.912.; hypothetical protein	complement(2047023..2047349)	Mycobacterium tuberculosis H37Rv	885588
NP_216321.1	CDS	Rv1805c	NC_000962.2	2047687	2048034	R	Rv1805c, (MTV049.27c), len: 115 aa. Hypothetical unknown protein.; hypothetical protein	complement(2047687..2048034)	Mycobacterium tuberculosis H37Rv	885470
YP_177843.1	CDS	PE20	NC_000962.2	2048072	2048371	D	Rv1806, (MTV049.28), len: 99 aa. Member of the Mycobacterium tuberculosis PE family of gly-, ala-rich proteins (see citation below), most similar to Rv1788|MTV049.10|AL022021 (99 aa), FASTA scores: opt: 334, E(): 4.7 e-15, (59.8% identity in 97 aa overlap). TBparse score is 0.932.; PE family protein	2048072..2048371	Mycobacterium tuberculosis H37Rv	885537
YP_177653.1	CDS	PPE31	NC_000962.2	<2048398	2049597	D	Rv1807, (MTV049.29), len: 399 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv1789|MTV049.11|AL022021 (393 aa), FASTA scores: opt: 1169, E(): 0, (49.5% identity in 412 aa overlap). TBparse score is 0.919.; PPE family protein	<2048398..2049597	Mycobacterium tuberculosis H37Rv	885072
YP_177844.1	CDS	PPE32	NC_000962.2	2049921	2051150	D	Rv1808, (MTV049.30), len: 409 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv1800|MTV049.22|AL022021 (655 aa), FASTA scores: opt: 1225, E(): 0, (55.1% identity in 423 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. TBparse score is 0.919.; PPE family protein	2049921..2051150	Mycobacterium tuberculosis H37Rv	885590
YP_177845.1	CDS	PPE33	NC_000962.2	2051282	2052688	D	Rv1809, (MTV049.31), len: 468 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to RV1802AL022021|MTV049.23 (463 aa), FASTA scores: opt: 1238, E(): 0, (51.2% identity in 471 aa overlap). TBparse score is 0.923.; PPE family protein	2051282..2052688	Mycobacterium tuberculosis H37Rv	885555
NP_216326.1	CDS	Rv1810	NC_000962.2	2052933	2053289	D	Rv1810, (MTCY16F9.04c), len: 118 aa. Conserved hypothetical protein, similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (possible N-terminal signal sequence) e.g. O53953|Rv1804c|MTV049.26c|AL022021 (108 aa), FASTA scores: opt: 361, E(): 9.6e-17, (53.5% identity in 101 aa overlap); Rv0622, and Rv1690, etc.; hypothetical protein	2052933..2053289	Mycobacterium tuberculosis H37Rv	885591
NP_216327.1	CDS	mgtC	NC_000962.2	2053443	2054147	D	Rv1811, (MTCY16F9.03c), len: 234 aa. Possible mgtC, magnesium (Mg2+) transport P-type ATPase C (transmembrane protein) (EC 3.6.3.1), highly similar to many e.g. NP_442124.1|NC_000911 Mg2+ transport ATPase from Synechocystis sp. strain PCC 6803 (234 aa); NP_251248.1|NC_002516 probable transport protein from Pseudomonas aeruginosa (230 aa); P22037|ATMC_SALTY|STM3764 magnesium transport ATPase protein C from Salmonella typhimurium (231 aa), FASTA scores: opt: 545, E(): 4.1e-30, (42.3% identity in 220 aa overlap); N-terminus of NP_213315.1|NC_000918 Mg(2+) transport ATPase from Aquifex aeolicus (225 aa); etc. BELONGS TO THE MGTC / SAPB FAMILY; Mg2+ transport P-type ATPase C	2053443..2054147	Mycobacterium tuberculosis H37Rv	885439
NP_216328.1	CDS	Rv1812c	NC_000962.2	2054157	2055359	R	Rv1812c, (MTCY16F9.02), len: 400 aa. Probable dehydrogenase (EC 1.-.-.-), similar to other dehydrogenases/oxidases e.g. AE001947|AE001947_10 NADH dehydrogenase II of Deinococcus radiodurans (379 aa), FASTA scores: opt: 404, E(): 3.4e-18, (26.4% identity in 363 aa overlap) and DHNA_HAEIN|P44856 nadh dehydrogenase (EC 1.6.99.3) (444 aa), FASTA scores: opt: 200, E(): 8.5e-06, (23.3% identity in 258 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical dehydrogenases Rv0392c, and Rv1854c|MTCY359.19 ndh probable NADH dehydrogenase (31.5% identity in 321 aa overlap).; dehydrogenase	complement(2054157..2055359)	Mycobacterium tuberculosis H37Rv	885487
NP_216329.1	CDS	Rv1813c	NC_000962.2	2055681	2056112	R	Rv1813c, (MTCY16F9.01), len: 143 aa. Conserved hypothetical protein. Possibly a exported protein with potential N-terminal signal sequence. Similar to Q11050|Rv1269c|MTCY50.13 hypothetical protein from Mycobacterium tuberculosis (124 aa), (42.7% identity in 143 aa overlap).; hypothetical protein	complement(2055681..2056112)	Mycobacterium tuberculosis H37Rv	885546
NP_216330.1	CDS	erg3	NC_000962.2	2056521	2057423	D	Rv1814, (MTCY1A11.29c), len: 300 aa. erg3, transmembrane C-5 sterol desaturase (EC 1.3.-.-) (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E(): 0.0011, (22.9% identity in 288 aa overlap). BELONGS TO THE STEROL DESATURASE FAMILY. [* Note: work of Jackson, C.J., Lamb, D.C., Kelly, D.E., Kelly, S.L., Characterization of a sterol delta 5,6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases].; membrane-bound C-5 sterol desaturase erg3 (sterol-c5-desaturase)	2056521..2057423	Mycobacterium tuberculosis H37Rv	885880
NP_216331.1	CDS	Rv1815	NC_000962.2	2057528	2058193	D	Rv1815, (MTCY1A11.28c), len: 221 aa. Conserved hypothetical protein, similar to G473456 hypothetical protein from Mycobacterium fortuitum (255 aa), FASTA scores: opt: 182, E(): 3.2e-05, (29.6% identity in 230 aa overlap).; hypothetical protein	2057528..2058193	Mycobacterium tuberculosis H37Rv	885430
NP_216332.1	CDS	Rv1816	NC_000962.2	2058256	2058960	D	Rv1816, (MTCY1A11.27c), len: 234 aa. Possible transcriptional regulatory protein. MEME analysis suggests similarity to putative Mycobacterium tuberculosis transcriptional regulators, Rv0653c, Rv0681. Contains helix-turn-helix motif at aa 38-59 (+4.30 SD).; transcriptional regulatory protein	2058256..2058960	Mycobacterium tuberculosis H37Rv	885340
NP_216333.1	CDS	Rv1817	NC_000962.2	2059595	2061058	D	Rv1817, (MTCY1A11.26c), len: 487 aa. Possible flavoprotein, similar to G746486 flavoprotein subunit of fumarate reductase fad domain homologue (474 aa), FASTA scores: opt: 223, E(): 5.7e-07, (24.1% identity in 489 aa overlap); and AJ236923|SFR236923_3 soluble fumarate reductase of Shewanella frigidimarina ifcA (588 aa), FASTA scores: opt: 310, E(): 2.5e-11, (27.3% identity in 484 aa overlap).; hypothetical protein	2059595..2061058	Mycobacterium tuberculosis H37Rv	885548
YP_177846.1	CDS	PE_PGRS33	NC_000962.2	2061178	2062674	R	Rv1818c, (MTCY1A11.25), len: 498 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many. Contains 2 x PS00583 pfkB family of carbohydrate kinases signature 1. Supposed localised to the cell surface (see citations below).; PE-PGRS family protein	complement(2061178..2062674)	Mycobacterium tuberculosis H37Rv	885551
NP_216335.1	CDS	Rv1819c	NC_000962.2	2062809	2064728	R	Rv1819c, (MTCY1A11.24), len: 639 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below), equivalent to AL008609|MLCB1788.47 hypothetical ABC transporter from Mycobacterium leprae (638 aa), (74.9% identity in 634 aa overlap). Also similar to other transmembrane ATP-binding proteins e.g. Q57335|Y036_HAEIN hypothetical ABC transporter ATP-binding protein from Haemophilus influenzae (592 aa), FASTA scores: opt: 1235, E(): 2.8e-61, (40.8% identity in 623 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; drugs-transport transmembrane ATP-binding protein ABC transporter	complement(2062809..2064728)	Mycobacterium tuberculosis H37Rv	885539
NP_216336.1	CDS	ilvG	NC_000962.2	2064799	2066442	D	Rv1820, (MTCY1A11.23c), len: 547 aa. Probable ilvG, acetolactate synthase (EC 4.1.3.18). Equivalent to AL008609|MLCB1788.46c ilvG from Mycobacterium leprae (548 aa) (86.1% identity in 548 aa overlap). Similar to ILVB_KLEPN|P27696 (559 aa), FASTA scores: opt: 660, E(): 2.9e-34, (29.1% identity in 549 aa overlap). Also similar to other Mycobacterium tuberculosis Ilv proteins e.g. Rv3003c (ilvB), etc. Contains PS00187 Thiamine pyrophosphate enzymes signature.; hypothetical protein	2064799..2066442	Mycobacterium tuberculosis H37Rv	885738
NP_216337.1	CDS	secA2	NC_000962.2	2066457	2068883	D	SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA	2066457..2068883	Mycobacterium tuberculosis H37Rv	885594
NP_216338.1	CDS	pgsA2	NC_000962.2	2069080	2069709	D	Rv1822, (MTCY1A11.21c), len: 209 aa. Probable pgsA2, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase (EC 2.7.8.5) (see citation below), integral membrane protein, equivalent to AL008609|MLCB1788_17 phosphatidyltransferase from Mycobacterium leprae (206 aa), FASTA score: (76.6% identity in 205 aa overlap). Also highly similar or similar to others e.g. CAB88885.1|AL353861 putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase from Streptomyces coelicolor (215 aa); AAC44003.1|U29587 phosphatidylglycerol phosphate synthase from Rhodobacter sphaeroides (227 aa); NP_405431.1|NC_003143 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Yersinia pestis (182 aa); P06978|PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Escherichia coli (181 aa), FASTA scores: opt: 252, E(): 2.8e-09, (29.7% identity in 175 aa overlap); etc. Also similar to Rv2746c|PGSA3|MTV002.11c CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE (PGP SYNTHASE) from Mycobacterium tuberculosis (209 aa). Contains PS00379 CDP-alcohol phosphatidyltransferases signature; and PS00075 Dihydrofolate reductase signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY.; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	2069080..2069709	Mycobacterium tuberculosis H37Rv	885126
NP_216339.1	CDS	Rv1823	NC_000962.2	2069702	2070625	D	Rv1823, (MTCY01A11.20), len: 307 aa. Conserved hypothetical protein, similar to P71582|MTCY10H4.12|RV0012 hypothetical protein CY10H4.12 from Mycobacterium tuberculosis (262 aa), FASTA scores: opt: 304, E(): 1.5e-12, (30.1% identity in 246 aa overlap).; hypothetical protein	2069702..2070625	Mycobacterium tuberculosis H37Rv	885547
NP_216340.1	CDS	Rv1824	NC_000962.2	2070654	2071019	D	Rv1824, (MTCY1A11.19c), len: 121 aa. Conserved hypothetical membrane protein similar to P28265|SBP_BACSU sbp protein from Bacillus subtilis (121 aa), FASTA scores: opt: 261, E(): 1.9e-12, (38.9% identity in 113 aa overlap).; hypothetical protein	2070654..2071019	Mycobacterium tuberculosis H37Rv	885719
NP_216341.1	CDS	Rv1825	NC_000962.2	2071036	2071914	D	Rv1825, (MTCY1A11.18c), len: 292 aa. Conserved hypothetical protein, weak similarity to Mycobacterium tuberculosis hypothetical proteins Q50610|MTCY1A11.20C|Rv1823|Z78020 (307 aa), FASTA scores: opt: 182, E(): 0.00044, (29.9% identity in 204 aa overlap); and Rv0012. Has a hydrophobic stretch, TMhelix from aa 67 to 85.; hypothetical protein	2071036..2071914	Mycobacterium tuberculosis H37Rv	885726
NP_216342.1	CDS	gcvH	NC_000962.2	2071952	2072356	D	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H	2071952..2072356	Mycobacterium tuberculosis H37Rv	885720
NP_216343.1	CDS	cfp17	NC_000962.2	2072596	2073084	D	Rv1827, (MTCY1A11.16c), len: 162 aa. cfp17, conserved hypothetical protein (see citation below), equivalent to O32919|MLCB1788.36c hypothetical protein from Mycobacterium leprae (162 aa), FASTA scores: opt: 888, E(): 0, (87.0% identity in 161 aa overlap).; hypothetical protein	2072596..2073084	Mycobacterium tuberculosis H37Rv	885735
NP_216344.1	CDS	Rv1828	NC_000962.2	2073081	2073824	D	Rv1828, (MTCY1A11.15c), len: 247 aa. Conserved hypothetical protein, equivalent to O32918|MLCB1788.35c|AL008609 hypothetical protein from Mycobacterium leprae (251 aa), FASTA scores: opt: 1397, E(): 0, (87.6% identity in 251 aa overlap).; hypothetical protein	2073081..2073824	Mycobacterium tuberculosis H37Rv	885336
NP_216345.1	CDS	Rv1829	NC_000962.2	2073943	2074437	D	Rv1829, (MTCY1A11.14c), len: 164 aa. Conserved hypothetical protein, equivalent to O32917|MLCB1788.34|AL008609 Hypothetical protein from Mycobacterium leprae (164 aa), FASTA scores: opt: 1011, E(): 0, (95.1% identity in 164 aa overlap). Also present in Aquifex aeolicus, etc.; hypothetical protein	2073943..2074437	Mycobacterium tuberculosis H37Rv	885743
NP_216346.1	CDS	Rv1830	NC_000962.2	2074841	2075518	D	Rv1830, (MTCY1A11.13c), len: 225 aa. Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical protein MLCB1788.33c|AL008609|O32916 (231 aa), FASTA scores: opt: 1307, E(): 0, (89.6% identity in 231 aa overlap).; hypothetical protein	2074841..2075518	Mycobacterium tuberculosis H37Rv	885740
NP_216347.1	CDS	Rv1831	NC_000962.2	2075571	2075828	D	Rv1831, (MTCY1A11.12c), len: 85 aa. Hypothetical unknown protein.; hypothetical protein	2075571..2075828	Mycobacterium tuberculosis H37Rv	885718
NP_216348.1	CDS	gcvB	NC_000962.2	2075877	2078702	D	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase	2075877..2078702	Mycobacterium tuberculosis H37Rv	885716
NP_216349.1	CDS	Rv1833c	NC_000962.2	2078929	2079789	R	Rv1833c, (MTCY1A11.10), len: 286 aa. Possible haloalkane dehalogenase (EC 3.8.1.5). Similar to several haloalkane dehalogenase e.g. CAB45532.1|AJ243259 from Mycobacterium bovis (300 aa); also similar to LINB_PSEPA|P51698 1,3,4,6-tetrachloro-1,4-cyclohexadien from Pseudomonas paucimobilis (295 aa), FASTA scores: opt: 314, E(): 1.5e-13, (33.1% identity in 281 aa overlap).; haloalkane dehalogenase	complement(2078929..2079789)	Mycobacterium tuberculosis H37Rv	885737
NP_216350.1	CDS	Rv1834	NC_000962.2	2079830	2080696	D	Rv1834, (MTCY1A11.09c), len: 288 aa. Probable hydrolase (EC 3.-.-.-), some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap).; hydrolase	2079830..2080696	Mycobacterium tuberculosis H37Rv	888761
NP_216351.1	CDS	Rv1835c	NC_000962.2	2080701	2082587	R	Rv1835c, (MTCY1A11.08), len: 628 aa. Conserved hypothetical protein, some similarity to putative acylases e.g. G216374 glutaryl 7-aca acylase precursor (634 aa) FASTA scores, opt: 202, E(): 3.5e-06, (25.1% identity in 669 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv2800 and Rv1215c.; hypothetical protein	complement(2080701..2082587)	Mycobacterium tuberculosis H37Rv	885877
NP_216352.1	CDS	Rv1836c	NC_000962.2	2082603	2084636	R	Rv1836c, (MTCY1A11.07), len: 677 aa. Conserved hypothetical protein. Equivalent to MLCB1788.28|AL008609 hypothetical protein from Mycobacterium leprae (710 aa), FASTA scores: opt: 2938, E(): 0, (66.0% identity in 714 aa overlap). Contains PS00036 bZIP transcription factors basic domain signature.; hypothetical protein	complement(2082603..2084636)	Mycobacterium tuberculosis H37Rv	885707
NP_216353.1	CDS	glcB	NC_000962.2	2084756	2086981	R	catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G	complement(2084756..2086981)	Mycobacterium tuberculosis H37Rv	885713
NP_216354.1	CDS	Rv1838c	NC_000962.2	2087257	2087652	R	Rv1838c, (MTCY359.35), len: 131 aa. Conserved hypothetical protein. Part of 14-membered Mycobacterium tuberculosis protein family with Rv2863|MTV003.09|AL008883 (126 aa), FASTA scores: opt: 293, E(): 1.5e-14, (38.2% identity in 123 aa overlap); Rv0749, Rv0277c, Rv2530c, etc. Also similar to AJ248288|CNSPAX06_181 Pyrococcus abyssi complete genome (136 aa), FASTA scores: opt: 197, E(): 2.2e-07, (33. 1% identity in 133 aa overlap).; hypothetical protein	complement(2087257..2087652)	Mycobacterium tuberculosis H37Rv	885744
NP_216355.1	CDS	Rv1839c	NC_000962.2	2087649	2087912	R	Rv1839c, (MTCY359.34), len: 87 aa. Conserved hypothetical protein. Some similarity to G217008 CHO-ORF1 (279 aa), FASTA scores: opt: 86, E(): 13, (38.7% identity in 62 aa overlap). TBparse score is 1.006.; hypothetical protein	complement(2087649..2087912)	Mycobacterium tuberculosis H37Rv	885750
YP_177847.1	CDS	PE_PGRS34	NC_000962.2	2087971	2089518	R	Rv1840c, (MTCY359.33), len: 515 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Similar to many e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa protein (603 aa), FASTA scores: opt: 1693, E(): 0, (53.1% identity in 612 aa overlap); etc.; PE-PGRS family protein	complement(2087971..2089518)	Mycobacterium tuberculosis H37Rv	885753
NP_216357.1	CDS	Rv1841c	NC_000962.2	2089681	2090718	R	Rv1841c, (MTCY359.32), len: 345 aa. Conserved hypothetical membrane protein. Some similarity to O07585|YHDP_BACSU HYPOTHETICAL 49.9 kDa PROTEIN from Bacillus subtilis (444 aa), FASTA scores: opt: 620, E(): 0, (31.1% identity in 350 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. Rv1842c, Rv2366c.; hypothetical protein	complement(2089681..2090718)	Mycobacterium tuberculosis H37Rv	885656
NP_216358.1	CDS	Rv1842c	NC_000962.2	2090718	2092085	R	Rv1842c, (MTCY359.31), len: 455 aa. Conserved hypothetical membrane protein. Similar to Z99109|0O7589 Potential integral membrane protein from Bacillus subtilis (461 aa), FASTA scores: opt: 723, E(): 0, (31.2% identity in 449 aa overlap). Similar to other Mycobacterium tuberculosis putative integral membrane proteins e.g. Rv2366c, Rv1841c. TBPARSE score is 0.883.; hypothetical protein	complement(2090718..2092085)	Mycobacterium tuberculosis H37Rv	885739
NP_216359.1	CDS	guaB1	NC_000962.2	2092259	2093698	R	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase	complement(2092259..2093698)	Mycobacterium tuberculosis H37Rv	885714
YP_177848.1	CDS	gnd1	NC_000962.2	2093731	2095188	R	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase	complement(2093731..2095188)	Mycobacterium tuberculosis H37Rv	885755
NP_216361.1	CDS	Rv1845c	NC_000962.2	2095218	2096168	R	Rv1845c, (MTCY359.28), len: 316 aa. Conserved hypothetical transmembrane protein. Equivalent to MLCB1788.18|AL008609 Hypothetical protein from Mycobacterium leprae (316 aa), FASTA scores: opt: 1762, E(): 0, (87.6% identity in 314 aa overlap). Similar to proteins in Streptomyces coelicolor e.g. SC10A7.04|AL078618.1. TBparse score is 0.901.; hypothetical protein	complement(2095218..2096168)	Mycobacterium tuberculosis H37Rv	885370
NP_216362.1	CDS	Rv1846c	NC_000962.2	2096183	2096599	R	Rv1846c, (MTCY359.27), len: 138 aa. Possible transcriptional regulatory protein. Equivalent to MLCB1788.17|AL008609 hypothetical protein from Mycobacterium leprae (142 aa), FASTA scores: opt: 736 E(): 0, (95.1% identity in 123 aa overlap). Also similar to BLAI_BACLI|P06555 penicillinase repressor (128 aa), fasta scores: opt: 114, E(): 0.12, (23.7% identity in 131 aa overlap). TBPARSE score is 0.921.; transcriptional regulatory protein	complement(2096183..2096599)	Mycobacterium tuberculosis H37Rv	885747
NP_216363.1	CDS	Rv1847	NC_000962.2	2096877	2097299	D	Rv1847, (MTCY359.26c), len: 140 aa. Conserved hypothetical protein, possible thioesterase, some similarity to YBDB proteins of Escherichia coli and H. influenzae e.g. P15050|YBDB_ECOLI HYPOTHETICAL 15.0 KD PROTEIN IN ENTA-CSTA INTERGENIC REGION (137 aa), FASTA scores: opt: 232, E(): 6.6e-10, (35.8% identity in 106 aa overlap); C48956|G142208 thioesterase from Arthrobacter sp (151 aa), FASTA score: opt: 254, E(): 1.7e-11, (33.3% identity in 138 aa overlap). Also similar to AF064959|AF064959_1 hypothetical protein from Coxiella burnetii (148 aa), FASTA score: opt: 264, E(): 9.3e- 12, (36.8% identity in 117 aa overlap). TBparse score is 0.903.; hypothetical protein	2096877..2097299	Mycobacterium tuberculosis H37Rv	885734
NP_216364.1	CDS	ureA	NC_000962.2	2097348	2097650	D	UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma	2097348..2097650	Mycobacterium tuberculosis H37Rv	885414
NP_216365.1	CDS	ureB	NC_000962.2	2097647	2097961	D	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); urease subunit beta	2097647..2097961	Mycobacterium tuberculosis H37Rv	885710
NP_216366.1	CDS	ureC	NC_000962.2	2097961	2099694	D	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha	2097961..2099694	Mycobacterium tuberculosis H37Rv	885359
NP_216367.1	CDS	ureF	NC_000962.2	2099694	2100329	D	Rv1851, (MTCY359.22c), len: 211 aa. ureF, urease accessory protein. Identical to UREF_MYCTU|P50050 from M. tuberculosis. TBPARSE score is 0.871.; urease accessory protein uref	2099694..2100329	Mycobacterium tuberculosis H37Rv	885532
NP_216368.1	CDS	ureG	NC_000962.2	2100340	2101014	D	Rv1852, (MTCY359.21c), len: 224 aa. ureG, urease accessory protein. Identical to UREG_MYCTU|P50051 from M. tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UREG FAMILY. TBPARSE score is 0.878.; urease accessory protein ureG	2100340..2101014	Mycobacterium tuberculosis H37Rv	885729
NP_216369.1	CDS	ureD	NC_000962.2	2101022	2101648	D	Rv1853, (MTCY359.20c), len: 208 aa. ureD, probable urease accessory protein. Similar to URED_YEREN|P42868 Urease operon ureD protein from Yersinia enterocolitica (325 aa), Fasta scores: opt: 114, E(): 0.37, (25.2% identity in 119 aa overlap). TBPARSE score is 0.904.; urease accessory protein ureD	2101022..2101648	Mycobacterium tuberculosis H37Rv	885705
NP_216370.1	CDS	ndh	NC_000962.2	2101651	2103042	R	Rv1854c, (MTCY359.19), len: 463 aa. Probable ndh, NADH dehydrogenase (EC 1.6.99.3) (see citations below), similar to several e.g. S74826 NADH dehydrogenase from Synechocystis sp. (445 aa), FASTA score: opt: 1228, E(): 0, (46.3% identity in 432 aa overlap). Highly similar to Rv0392c|Z84725|g1817703 from Mycobacterium tuberculosis (470 aa), FASTA scores: opt: 1911, E(): 0, (64.7% identity in 459 aa overlap); and Rv1812c. TBPARSE score is 0.897.; NADH dehydrogenase	complement(2101651..2103042)	Mycobacterium tuberculosis H37Rv	885746
NP_216371.1	CDS	Rv1855c	NC_000962.2	2103184	2104107	R	Rv1855c, (MTCY359.18), len: 307 aa. Possible oxidoreductase (EC 1.-.-.-), possibly a monooxygenase. Contains PS00217 Sugar transport proteins signature 2, probably fortuitously. Similar to G487716 (78-11) LINCOMYCIN PRODUCTION GENES (29.2% identity in 154 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. Rv0953c, Rv0791c, Rv0132c, Rv2951c, etc.; oxidoreductase	complement(2103184..2104107)	Mycobacterium tuberculosis H37Rv	885736
NP_216372.1	CDS	Rv1856c	NC_000962.2	2104146	2104823	R	Rv1856c, (MTCY359.17), len: 225 aa. Possible oxidoreductase (EC 1.-.-.-). Equivalent to MLCB1788.11c|AL008609 OXIDOREDUCTASE from Mycobacterium leprae (224 aa), FASTA scores: opt: 1211, E(): 0; (80.4% identity in 224 aa overlap). Some similarity to dehydrogenases of short-chain dehydrogenase/reductase family and fatty-acyl CoA reductases e.g. P16543|DHK2_STRVN GRANATICIN POLYKETIDE SYNTHASE P (249 aa), FASTA score: opt: 194, E(): 1.1e-05, (32.5% identity in 237 aa overlap).; short chain dehydrogenase	complement(2104146..2104823)	Mycobacterium tuberculosis H37Rv	885708
NP_216373.1	CDS	modA	NC_000962.2	2104985	2105770	D	Rv1857, (MTCY359.16c), len: 261 aa. Probable modA, molybdate-binding protein attached to membrane by lipid-modified N-terminal cysteine (contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site), component of molybdate transport system (see citations below). Shows strong similarity to precursors of periplasmic molybdate/sulphate binding proteins e.g. O31229|Y10817|ANY108174 ModA from Arthrobacter nicotinovorans (260 aa), FASTA score: opt: 725, E(): 0, (47.8% identity in 249 aa overlap). TBparse score is 0.926.; molybdate-binding lipoprotein	2104985..2105770	Mycobacterium tuberculosis H37Rv	885655
NP_216374.1	CDS	modB	NC_000962.2	2105773	2106567	D	Rv1858, (MTCY359.15c), len: 264 aa. Probable modB, molybdenum-transport integral membrane protein ABC transporter (see citation below), similar to others e.g. Y10817|ANY108175 ModB from Arthrobacter (239 aa), FASTA scores: opt: 937, E(): 0, (67.8% identity in 230 aa overlap); etc. Similar to other Mycobacterium tuberculosis transport proteins e.g. Rv2039c, Rv2316, etc. TBparse score is 0.911.; molbdenum-transport integral membrane protein ABC transporter	2105773..2106567	Mycobacterium tuberculosis H37Rv	885723
NP_216375.1	CDS	modC	NC_000962.2	2106574	2107683	D	Rv1859, (MTCY359.14c), len: 369 aa. Probable modC, molybdenum-transport ATP-binding protein ABC transporter (see citation below), similar to others e.g. Y10817|ANY108176 ModC from Arthrobacter (349 aa), FASTA scores: opt: 895, E(): 0, (46.0% identity in 361 aa overlap); etc. Shows similarity to other Mycobacterium tuberculosis ABC-transporter proteins e.g. Rv0073, Rv1238, Rv2564, etc. Contains both PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signatures involved in molybdate uptake. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.918.; molybdenum ABC transporter ATP-binding protein	2106574..2107683	Mycobacterium tuberculosis H37Rv	885731
YP_177849.1	CDS	apa	NC_000962.2	2107736	2108713	D	Rv1860, (MT1908, MTCY359.0013), len: 325 aa. apa (alternate gene names: mpt32, modD), Ala-, Pro-rich 45/47 kDa secreted protein, very similar to P46842|N43L_MYCLE from Mycobacterium leprae (287 aa), FASTA scores: opt: 1166, E(): 0, (66.4% identity in 298 aa overlap). Known to be glycosylated fibronectin-binding protein (see some citations). CHANGES IN THE MANNOSYLATION PATTERN OF THIS PROTEIN AFFECT ITS ABILITY TO STIMULATE T-LYMPHOCYTE RESPONSE. MAJOR IMMUNODOMINANT ANTIGEN THAT HAS POTENTIAL AS A VACCINE AGAINST TUBERCULOSIS. APA-ELISA COULD BE USED IN DIAGNOSIS. TBparse score is 0.924.; mpt32; modD; hypothetical protein	2107736..2108713	Mycobacterium tuberculosis H37Rv	885896
NP_216377.1	CDS	Rv1861	NC_000962.2	2109165	2109470	D	Rv1861, (MTCY359.12c), len: 101 aa. Probable conserved transmembrane protein, showing weak similarity to AE002069|AE002069_10 hypothetical protein from Deinococcus radiodurans (146 aa), FASTA scores: opt: 154, E(): 0.0027, (30.8% identity in 104 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.863.; transmembrane protein	2109165..2109470	Mycobacterium tuberculosis H37Rv	885741
NP_216378.1	CDS	adhA	NC_000962.2	2109544	2110584	D	Rv1862, (MTCY359.11), len: 346 aa. Probable adhA, alcohol dehydrogenase (EC 1.1.1.1), similar to ADH2_BACST|P42327 alcohol dehydrogenase (339 aa), FASTA scores: opt: 630, E(): 2.4e-32 (34.4% identity in 320 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. TBPARSE score is 0.899.; alcohol dehydrogenase AdhA	2109544..2110584	Mycobacterium tuberculosis H37Rv	885652
NP_216379.1	CDS	Rv1863c	NC_000962.2	2110591	2111361	R	Rv1863c, (MTCY359.10), len: 256 aa. Probable conserved integral membrane protein, similar to Rv0804|Z95618|MTCY7H7A.05 Hypothetical protein from Mycobacterium tuberculosis (209 aa), FASTA scores: opt: 199, E(): 1e-06, (33.2% identity in 220 aa overlap); and Rv0658c. TBPARSE score is 0.912.; integral membrane protein	complement(2110591..2111361)	Mycobacterium tuberculosis H37Rv	885722
NP_216380.1	CDS	Rv1864c	NC_000962.2	2111354	2112109	R	Rv1864c, (MTCY359.09), len: 251 aa. Conserved hypothetical protein. Similar to other hypothetical proteins e.g. AL031317|SC6G4.43 from Streptomyces coelicolor cosmid 6G (233 aa), FASTA scores: opt: 716, E(): 0, (54.4% identity in 215 aa overlap); also P43976|YIIM_HAEIN hypothetical protein hi0278 (221 aa), FASTA scores: opt: 223, E(): 3.8e-08, (29.5% identity in 173 aa overlap). TBPARSE score is 0.919; hypothetical protein	complement(2111354..2112109)	Mycobacterium tuberculosis H37Rv	885800
NP_216381.1	CDS	Rv1865c	NC_000962.2	2112106	2112966	R	Rv1865c, (MTCY359.08), len: 286 aa. Probable short-chain dehydrogenase (EC 1.-.-.-), highly similar to C-terminus of NP_301650.1|NC_00267 putative oxidoreductase from Mycobacterium leprae (596 aa). Also similar to various dehydrogenases, generally belonging to short-chain family, e.g. AAG02168.1|AF212041_24|AF212041 3-oxoacyl-(acylcarrier protein) reductase from Zymomonas mobilis (251 aa); P50198|LINX_PSEPA 2,5-DICHLORO-2,5-CYCLOHEXADIENE-1,4-DIOL DEHYDROGENASE from Sphingomonas paucimobilis (250 aa); NP_105680.1|NC_002678 sorbitol dehydrogenase (also similar to acetoin reductase) from Mesorhizobium loti (256 aa); etc. And highly similar to C-terminus of ephD|Rv2214c|MTCY190.25c from Mycobacterium tuberculosis (592 aa); and many other oxidoreductases from Mycobacterium tuberculosis e.g. Y00P_MYCTU|Q10402 putative oxidoreductase (650 aa), FASTA scores: opt: 439, E(): 8.9e-20, (32.5% identity in 280 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short chain dehydrogenase	complement(2112106..2112966)	Mycobacterium tuberculosis H37Rv	885806
NP_216382.1	CDS	Rv1866	NC_000962.2	2113140	2115476	D	Rv1866, (MTCY359.07c), len: 778 aa. Conserved hypothetical protein, N-terminal region similar to fatty acyl-CoA racemases e.g. Rv0855, Rv1143, and C-terminal region (from aa 370) similar to L-carnitine dehydratases, racemases, and Rv3272|MTCY71.12 Mycobacterium tuberculosis (394 aa), FASTA score: opt: 472, E(): 2.1e-21, (29.9% identity in 388 aa overlap). Also similar to P31572|CAIB_ECOLI L-CARNITINE DEHYDRATASE (EC 4.2.1.89) (405 aa), FASTA score: opt: 306, E(): 2.1e-11, (23.3% identity in 424 aa overlap). TBPARSE score is 0.921.; hypothetical protein	2113140..2115476	Mycobacterium tuberculosis H37Rv	885733
NP_216383.1	CDS	Rv1867	NC_000962.2	2115764	2117248	D	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase	2115764..2117248	Mycobacterium tuberculosis H37Rv	885704
NP_216384.1	CDS	Rv1868	NC_000962.2	2117347	2119446	D	Rv1868, (MTCY359.05c), len: 699 aa. Conserved hypothetical protein, similar to products of three consecutive ORFS in Mycobacterium leprae MLCB2052.18|Z98604|B2052 (257 aa), FASTA scores: opt: 314, E(): 9.9e-12, (35.2% identity in 213 aa overlap); MLCB2052.17, and MLCB2052.16. Also similar to M. tuberculosis hypothetical protein Rv2047c. TBPARSE score is 0.926.; hypothetical protein	2117347..2119446	Mycobacterium tuberculosis H37Rv	885757
NP_216385.1	CDS	Rv1869c	NC_000962.2	2119460	2120695	R	Rv1869c, (MTCY359.04), len: 411 aa. Probable reductase (1.-.-.-). Similar to several reductases e.g. CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa); THCD_RHOSO|P43494 rhodocoxin reductase (426 aa), FASTA scores: opt: 904, E(): 0, (40.8% identity in 370 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv0688 (406 aa) (39.9% identity in 391 aa overlap); and Rv0253 (nitrite reductase subunit). TBPARSE score is 0.918.; reductase	complement(2119460..2120695)	Mycobacterium tuberculosis H37Rv	885796
NP_216386.1	CDS	Rv1870c	NC_000962.2	2120795	2121430	R	Rv1870c, (MTCY359.03), len: 211 aa. Conserved hypothetical protein. Some similarity to SC6F7.17c hypothetical protein from Streptomyces coelicolor (216 aa). TBPARSE score is 0.939; hypothetical protein	complement(2120795..2121430)	Mycobacterium tuberculosis H37Rv	885797
NP_216387.1	CDS	Rv1871c	NC_000962.2	2121495	2121884	R	Rv1871c, (MTCY359.02), len: 129 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Q11057|Rv1261|MTCY50.21 (149 aa), FASTA score: opt: 125, E(): 0.019, (32.6% identity in 89 aa overlap); Rv0523c, and Rv1598c. TBPARSE score is 0.909; hypothetical protein	complement(2121495..2121884)	Mycobacterium tuberculosis H37Rv	885804
NP_216388.1	CDS	lldD2	NC_000962.2	2121907	2123151	R	Rv1872c, (MTCY180.46, MTCY359.01), len: 414 aa (start uncertain). Possible lldD2, L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3), similar to other lactate dehydrogenases and other oxidases e.g. LLDD_ECOLI|P33232 l-lactate dehydrogenase (cytochrome) from Escherichia coli strain K12 (396 aa), FASTA results: opt: 674, E(): 1.1e-37, (40.5% identity in 279 aa overlap); Q51135 LACTATE DEHYDROGENASE from Neisseria meningitidis (390 aa), FASTA results: opt: 309, E(): 4.1e-15, (42.5% identity in 113 aa overlap); etc. Also shows similarity with Rv0694|lldD1|MTCY210.11 POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) from Mycobacterium tuberculosis (396 aa). Contains PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. BELONGS TO THE FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASES FAMILY. TBparse score is 0.905.; L-lactate dehydrogenase (cytochrome) LldD2	complement(2121907..2123151)	Mycobacterium tuberculosis H37Rv	885754
NP_216389.1	CDS	Rv1873	NC_000962.2	2123174	2123611	D	Rv1873, (MTCY180.45c), len: 145 aa. Conserved hypothetical protein. Some similarity to AL591783 hypothetical protein from Sinorhizobium meliloti. TBparse score is 0.909.; hypothetical protein	2123174..2123611	Mycobacterium tuberculosis H37Rv	885789
NP_216390.1	CDS	Rv1874	NC_000962.2	2123684	2124370	D	Rv1874, (MTCY180.44c), len: 228 aa. Hypothetical unknown protein, TBparse score is 0.928; hypothetical protein	2123684..2124370	Mycobacterium tuberculosis H37Rv	885748
NP_216391.1	CDS	Rv1875	NC_000962.2	2124381	2124824	D	Rv1875, (MTCY180.43c), len: 147 aa. Conserved hypothetical protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: opt: 178, E(): 7.4e-06, (26.9% identity in 130 aa overlap); Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1 e-09, (38.7% identity in 137 aa overlap). TBparse score is 0.908; hypothetical protein	2124381..2124824	Mycobacterium tuberculosis H37Rv	885793
NP_216392.1	CDS	bfrA	NC_000962.2	2125340	2125819	D	Rv1876, (MTCY180.42c), len: 159 aa. Probable bfrA (alternate gene name: bfr), bacterioferritin (see citation below), similar to BFR_MYCLE|P43315 bacterioferritin (bfr) from Mycobacterium leprae (159 aa), FASTA results: opt: 958, E(): 0, (90.6% identity in 159 aa overlap). Also similar to Rv3841|MTCY01A6.28c|bfrB POSSIBLE BACTERIOFERRITIN from Mycobacterium tuberculosis (181 aa). BELONGS TO THE BACTERIOFERRITIN FAMILY. TBparse score is 0.913.; bfr; bacterioferritin	2125340..2125819	Mycobacterium tuberculosis H37Rv	885767
NP_216393.1	CDS	Rv1877	NC_000962.2	2125904	2127967	D	Rv1877, (MTCY180.41c), len: 687 aa. Probable conserved integral membrane protein, part of major facilitator superfamily (MFS), similar to many antibiotic and drug efflux proteins. Similar to e.g. Q56175 TU22 DTDP-GLUCOSE DEHYDRTATASE from Streptomyces violaceoruber (557 aa), FASTA scores: opt: 895, E(): 0, (34.7% identity in 528 aa overlap). Also similar to Mycobacterium tuberculosis relatives protein, include Rv3728, Rv3239c, Rv2846c, etc. Contains PS00217 Sugar transport proteins signature 2 (PS00217). TBparse score is 0.916.; integral membrane protein	2125904..2127967	Mycobacterium tuberculosis H37Rv	885654
NP_216394.1	CDS	glnA3	NC_000962.2	2128022	2129374	D	Rv1878, (MTCY180.40c), len: 450 aa. Probable glnA3, glutamine synthetase class I (EC 6.3.1.2), similar to many e.g. GLNA_BACCE|P19064 from Bacillus cereus (443 aa), FASTA results: opt: 497, E(): 5.2e-23, (29.0% identity in 331 aa overlap); etc. Also similar to C-terminus of FLUG_EMENI|P38094 flug protein from emericella nidulans (865 aa), FASTA scores: opt: 227, E (): 6.4e-13, (29.9% identity in 394 aa overlap). Note that the downstream ORF MTCY180.39c is similar to the N-terminus. Also similar to three other potential glutamine synthases in M. tuberculosis: Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY42 7. 03c; Rv2860c|MTV003.06c|glnA4 and Rv2220|glnA1. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY. TBparse score is 0.925.; glutamine synthetase	2128022..2129374	Mycobacterium tuberculosis H37Rv	885761
NP_216395.1	CDS	Rv1879	NC_000962.2	2129377	2130513	D	Rv1879, (MTCY180.39c), len: 378 aa. Conserved hypothetical protein, similar to SCC22.14c|AL096839 hypothetical protein from Streptomyces coelicolor (368 aa), FASTA results: opt: 772, E(): 0 (40.3% identity in 372 aa overlap); and to N-terminal half of nodulin/glutamate-ammonia ligase-like protein. Some similarity to N-terminus of AL132958|ATT4D2_11 Arabidopsis thaliana (845 aa), FASTA results: opt: 354, E(): 3.1e-16, (29.2% identity in 383 aa overlap); and to P38094|FLUG_EMENI Flug protein of Emericella nidulans (865 aa), FASTA results: opt: 306, E(): 6.2e-13, (26.5% identity in 415 aa overlap). Note that the upstream ORF Rv1878|MTCY18 0.40c is similar to the C-terminus. TBparse score is 0.933; hypothetical protein	2129377..2130513	Mycobacterium tuberculosis H37Rv	885650
NP_216396.1	CDS	cyp140	NC_000962.2	2130541	2131857	R	Rv1880c, (MT1929, MTCY180.38), len: 438 aa. Probable cyp140, cytochrome p450 (EC 1.14.-.-). Similar to Q00441|CPXJ_SACER 6-deoxyerythronolide beta hydroxylase (404 aa), FASTA scores: opt: 775, E(): 0, (44.2% identity in 319 aa overlap); and other members of the cytochrome P450 family. Related to Mycobacterium tuberculosis proteins include: Rv0766c, Rv2266, Rv0778, etc. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY. TBparse score is 0.926.; cytochrome p450 140 CYP140	complement(2130541..2131857)	Mycobacterium tuberculosis H37Rv	885758
NP_216397.1	CDS	lppE	NC_000962.2	2131907	2132329	R	Rv1881c, (MTCY180.37), len: 140 aa. Possible lppE, lipoprotein, showing some similarity to L12238|MSG18S19K_1 19K antigen from Mycobacterium intracellulare (162 aa), FASTA scores: opt: 137, E(): 0.0069, (27.6% identity in 156 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.941.; lipoprotein LppE	complement(2131907..2132329)	Mycobacterium tuberculosis H37Rv	885762
NP_216398.1	CDS	Rv1882c	NC_000962.2	2132370	2133203	R	Rv1882c, (MTCY180.36), len: 277 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases, generally belonging to SDR family, e.g. NP_250789.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (251 aa); NP_421760.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (270 aa); NP_107167.1|NC_002678 oxidoreductase (short chain dehydrogenase/reductase family) from Mesorhizobium loti (253 aa); P50197|LINC_PSEPA 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 aa), FASTA scores: opt: 301, E(): 2.3e-12, (30.0% identity in 223 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Rv3057c, Rv1245, etc. Contains possible helix-turn-helix motif at aa 246-267 (+4.32 SD). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short chain dehydrogenase	complement(2132370..2133203)	Mycobacterium tuberculosis H37Rv	885782
NP_216399.1	CDS	Rv1883c	NC_000962.2	2133231	2133692	R	Rv1883c, (MTCY180.35), len: 153 aa. Conserved hypothetical protein, some similarity to hypothetical proteins e.g. Rv2778c|AL008967|MTV002.43 from Mycobacterium tuberculosis (156 aa), FASTA score: opt: 212, E(): 3.1e-08, (34.4% identity in 151 aa overlap). Also similar to U75434|SAU75434_3 Nsh-OrfB from Streptomyces actuosus (173 aa), FASTA score: opt: 207, E(): 1.8e-07, (40.2% identity in 102 aa overlap). TBparse score is 0.923; hypothetical protein	complement(2133231..2133692)	Mycobacterium tuberculosis H37Rv	885484
NP_216400.1	CDS	rpfC	NC_000962.2	2133731	2134261	R	Rv1884c, (MTCY180.34), len: 176 aa. Probable rpfC, resuscitation promoting factor (see citation below), similar to Z96935|MLRPF_1 resusicitation-promoting factor from Micrococcus luteus (220 aa), FASTA score: opt: 287, E() : 3.3e-11, (40.0% identity in 120 aa overlap). Also similar to others from Mycobacterium tuberculosis: Rv2389c|MTCY253.32|RPFD PROBABLE RESUSCITATION-PROMOTING FACTOR (154 aa), FASTA score: opt: 382, E(): 7.1e-17, (55.4% identity in 101 aa overlap); Rv0867c|RPFA (N-terminal part), Rv2450c|RPFE, and Rv1009|RPFB (C-terminal part). TBparse score is 0.927.; resuscitation-promoting factor RpfC	complement(2133731..2134261)	Mycobacterium tuberculosis H37Rv	885759
NP_216401.1	CDS	Rv1885c	NC_000962.2	2134273	2134872	R	catalyzes the interconversion of chorismate to prephenate; chorismate mutase	complement(2134273..2134872)	Mycobacterium tuberculosis H37Rv	885772
NP_216402.1	CDS	fbpB	NC_000962.2	2134890	2135867	R	Rv1886c, (MT1934, MTCY180.32), len: 325 aa. fbpB (alternate gene names: mpt59, 85B), precursor of the 85-B antigen (fibronectin-binding protein B) (mycolyl transferase 85B) (EC 2.3.1.-) (see citations below), highly similar to other Mycobacterial antigen precursors e.g. P12942|A85B_MYCBO ANTIGEN 85-B PRECURSOR from Mycobacterium bovis (323 aa); P21160|A85B_MYCKA ANTIGEN 85-B PRECURSOR from Mycobacterium kansasii (325 aa); etc. Also highly similar to Mycobacterium tuberculosis antigen precursors: Rv3804c|fbpA (338 aa), Rv0129c|fbpC2 (340 aa), and Rv3803c|fbpC1 (299 aa). TBparse score is 0.912.; mpt59; 85B; secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen)	complement(2134890..2135867)	Mycobacterium tuberculosis H37Rv	885785
NP_216403.1	CDS	Rv1887	NC_000962.2	2136258	2137400	D	Rv1887, (MTCY180.31), len: 380 aa. Hypothetical unknown protein; contains eukaryotic thiol (cysteine) proteases histidine active site at N-terminus (PS00639) and Pro-rich region near C-terminus. TBparse score is 0.935.; hypothetical protein	2136258..2137400	Mycobacterium tuberculosis H37Rv	885247
NP_216404.1	CDS	Rv1888c	NC_000962.2	2137519	2138079	R	Rv1888c, (MTCY180.30), len: 186 aa. Possible transmembrane protein. TBparse score is 0.926.; transmembrane protein	complement(2137519..2138079)	Mycobacterium tuberculosis H37Rv	885267
YP_177654.1	CDS	Rv1888A	NC_000962.2	2138444	2138617	R	Rv1888A, len: 57 aa. Conserved hypothetical protein. Possibly continuation of Rv1889c, part of large family of Mycobacterium tuberculosis proteins with conserved N-terminal domain of 120 aa. Includes: C-terminus of Rv0726c|P95074 CONSERVED HYPOTHETICAL PROTEIN (367 aa), FASTA scores: opt: 295, E(): 3.1e-15, (73.684% identity in 57 aa overlap); C-terminus of Rv3399|Q50726|MTCY78.29c CONSERVED HYPOTHETICAL PROTEIN (348 aa), FASTA scores: opt: 504, E(): 7.3e-29, (64.2% identity in 120 aa overlap); C-terminus of Rv0731c; etc.; hypothetical protein	complement(2138444..2138617)	Mycobacterium tuberculosis H37Rv	3205115
NP_216405.1	CDS	Rv1889c	NC_000962.2	2138661	2139017	R	Rv1889c, (MTCY180.29), len: 118 aa. Conserved hypothetical protein. Part of large family of Mycobacterium tuberculosis proteins with conserved N-terminal domain of 120 aa. Includes: Rv3399|Q50726|MTCY78.29C CONSERVED HYPOTHETICAL PROTEIN (348 aa), FASTA results: opt: 504, E(): 7.3e-29, (64.2% identity in 120 aa overlap); Rv0726c|P95074; Rv0731c; etc. Rv1888A possibly continuation of this CDS. TBparse score is 0.901.; hypothetical protein	complement(2138661..2139017)	Mycobacterium tuberculosis H37Rv	885788
NP_216406.1	CDS	Rv1890c	NC_000962.2	2139076	2139687	R	Rv1890c, (MTCY180.28), len: 203 aa. Hypothetical unknown protein. TBparse score is 0.933; hypothetical protein	complement(2139076..2139687)	Mycobacterium tuberculosis H37Rv	885786
NP_216407.1	CDS	Rv1891	NC_000962.2	2139741	2140148	D	Rv1891, (MTCY180.27c), len: 135 aa. Conserved hypothetical protein. Equivalent to MLCB561.09|AL049571 hypothetical protein from Mycobacterium leprae (134 aa), FASTA scores: opt: 800, E(): 0, (79.7% identity in 133 aa overlap). TBparse score is 0.932.; hypothetical protein	2139741..2140148	Mycobacterium tuberculosis H37Rv	885094
NP_216408.1	CDS	Rv1892	NC_000962.2	2140165	2140476	D	Rv1892, (MTCY180.26c), len: 103 aa. Probable membrane protein. TBparse score is 0.922.; hypothetical protein	2140165..2140476	Mycobacterium tuberculosis H37Rv	885090
NP_216409.1	CDS	Rv1893	NC_000962.2	2140486	2140704	D	Rv1893, (MTCY180.25c), len: 72 aa. Conserved hypothetical protein. Equivalent to MLCB561.11|AL049571 hypothetical protein from Mycobacterium leprae (74 aa), FASTA scores: opt: 317, E(): 4.6e-15, (69.4% identity in 72 aa overlap). TBparse score is 0.857.; hypothetical protein	2140486..2140704	Mycobacterium tuberculosis H37Rv	885269
NP_216410.1	CDS	Rv1894c	NC_000962.2	2140739	2141869	R	Rv1894c, (MTCY180.24), len: 376 aa. Conserved hypothetical protein, weak similarity to some oxidoreductases e.g. Q01284 2-NITROPROPANE DIOXYGENASE PRECURSOR (378 aa), FASTA results: opt: 204, E(): 5.8e-06, (34.3% identity in 140 aa overlap). Similar to hypothetical Mycobacterium tuberculosis proteins e.g. Rv3553|MTCY03C7.02c (355 aa), FASTA results: opt: 296, E(): 1.6e-10, (32.9% identity in 167 aa overlap); Rv1533 (375 aa) (48.1% identity in 376 aa overlap); Rv0021c, Rv2781c. TBparse score is 0.902.; hypothetical protein	complement(2140739..2141869)	Mycobacterium tuberculosis H37Rv	885081
NP_216411.1	CDS	Rv1895	NC_000962.2	2142521	2143675	D	Rv1895, (MTCY180.23c), len: 384 aa. Possible dehydrogenase (EC 1.1.-.-), similar to various sorbitol and alcohol dehydrogenases, and to putative glutathione-dependent aldehyde dehydrogenase e.g DHSO_BACSU|Q06004 Sorbitol dehydrogenase (EC 1.1.1.14) from Streptomyces coelicolor (352 aa), FASTA results: opt: 506, E(): 7.2e-24, (30.6% identity in 350 aa overlap); and AL109962|SCJ1.28 PUTATIVE ZINC-CONTAINING DEHYDROGENASE from Streptomyces coelicolor (356 aa), FASTA results: opt: 634, E(): 2.9e-30, (34.7% identity in 357 aa overlap). Also similar to other Mycobacterium tuberculosis dehydrogenases. Note that there is a substantial (134 bp) overlap at the C-terminus with the C-terminus of the downstream ORF, although both appear to be true coding regions. TBparse score is 0.922.; dehydrogenase	2142521..2143675	Mycobacterium tuberculosis H37Rv	885148
NP_216412.1	CDS	Rv1896c	NC_000962.2	2143535	2144446	R	Rv1896c, (MTCY180.22), len: 303 aa. Conserved hypothetical protein. Similar to several (14) hypothetical Mycobacterium tuberculosis proteins e.g. Rv0145|MTCI5.19 (317 aa), FASTA results: opt: 720, E(): 0, (41.6% identity in 308 aa overlap); Q10552|YZ21_MYCTU (325 aa), opt: 689, E(): 0, (40.5% identity in 304 aa overlap); Rv0726c, Rv0731c, Rv3399, etc. and to related proteins in other actinomycetes. Note that there is a substantial (134 bp) overlap at the C-terminus with the C-terminus of the downstream ORF, although both appear to be true coding regions. TBparse score is 0.946; hypothetical protein	complement(2143535..2144446)	Mycobacterium tuberculosis H37Rv	885915
NP_216413.1	CDS	Rv1897c	NC_000962.2	2144451	2144882	R	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase	complement(2144451..2144882)	Mycobacterium tuberculosis H37Rv	885893
NP_216414.1	CDS	Rv1898	NC_000962.2	2144940	2145248	D	Rv1898, (MTCY180.20c), len: 102 aa. Conserved hypothetical protein, some similarity to other hypothetical proteins e.g. Q58452 from METHANOCOCCUS JANNASCH II (100 aa), FASTA results: opt: 152, E(): 9.1e-05, (31.5% identity in 92 aa overlap); and AE000771|AE000771_2 from Aquifex aeolicus (157 aa), FASTA results: opt: 246, E(): 3.2e-11, (39.0% identity in 100 aa overlap). TBparse score is 0.874.; hypothetical protein	2144940..2145248	Mycobacterium tuberculosis H37Rv	885089
NP_216415.1	CDS	lppD	NC_000962.2	2145214	2146245	R	Rv1899c, (MTCY180.19), len: 343 aa. Possible lipoprotein; contains appropriately localized lipoprotein lipid attachment site (PS00013). Some similarity to C-terminal part of AE000717|AE000717_4 hypothetical protein from Aquifex aeolicus section 49 (165 aa), FASTA results: opt: 372, E(): 2.3e-14, (43.5% identity in 147 aa overlap); and Q44020 4-hydroxybutyrate dehydrogenase (173 aa), FASTA results: opt: 272, E(): 4.7e-09, (35.8% identity in 165 aa overlap).; lipoprotein LppD	complement(2145214..2146245)	Mycobacterium tuberculosis H37Rv	885138
NP_216416.1	CDS	lipJ	NC_000962.2	2146245	2147633	R	Rv1900c, (MTCY180.18), len: 462 aa. Probable lipJ, lignin peroxidase, with some similarity to esterases, hydrolases and hypothetical Mycobacterium tuberculosis proteins e.g. Q43936 BETA-KETOADIPATE ENOL-LACTONE HYDROLASE from Acinetobacter calcoaceticus (267 aa), FASTA results: opt: 217, E(): 1.7e-07, (29.2% identity in 260 aa overlap). Also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv2212|Q10400|YM12_MYCTU (378 aa), FASTA results: opt: 216, E(): 6.7e-07, (27.7% identity in 285 aa overlap).; lignin peroxidase LIPJ	complement(2146245..2147633)	Mycobacterium tuberculosis H37Rv	885151
NP_216417.1	CDS	cinA	NC_000962.2	2147662	2148954	D	Rv1901, (MTCY180.17c), len: 430 aa. Probable cinA-like protein, strong similarity to competence damage proteins CinA of Bacillus subtilis and S. pneumoniae. FASTA results: Q55760 HYPOTHETICAL 44.7 kDa PROTEIN (416 aa) opt: 755, E(): 0, (36.0% identity in 433 aa overlap). TBparse score is 0.910.; competence damage-inducible protein A	2147662..2148954	Mycobacterium tuberculosis H37Rv	885149
NP_216418.1	CDS	nanT	NC_000962.2	2149006	2150274	R	Rv1902c, (MTCY180.16), len: 422 aa. Probable nanT, sialic acid-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. Q48076 SIALIC ACID TRANSPORTER (407 aa), FASTA results: opt: 443, E(): 5.4e-22, (26.7% identity in 389 aa overlap); etc. Some similarity to MTCI364.12|O05301 conserved hypothetical protein from Mycobacterium tuberculosis (425 aa), FASTA results: opt: 251, E(): 1.1e-09, (23.5% identity in 417 aa overlap). Contains sugar transport proteins signature 2 (PS00217). TBparse score is 0.920.; sialic acid-transport integral membrane protein NanT	complement(2149006..2150274)	Mycobacterium tuberculosis H37Rv	885057
NP_216419.1	CDS	Rv1903	NC_000962.2	2150364	2150768	D	Rv1903, (MTCY180.15c), len: 134 aa. Probable conserved membrane protein, similar to Q53868|YPT3_STRCO hypothetical 15.9 kDa protein from Streptomyces coelicolor (148 aa) opt: 323, E(): 1.3e-16, (42.9% identity in 126 aa overlap); and equivalent to AJ000521|MLCOSL672_3 from Mycobacterium leprae (139 aa), FASTA results: opt: 680, E(): 0, (80.6% identity in 129 aa overlap). TBparse score is 0.915.; hypothetical protein	2150364..2150768	Mycobacterium tuberculosis H37Rv	885643
NP_216420.1	CDS	Rv1904	NC_000962.2	2150954	2151385	D	Rv1904, (MTCY180.14c), len: 143 aa. Conserved hypothetical protein, some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08|P71937 (148 aa), FASTA results: opt: 456, E( ): 2.7e-23, (52.8% identity in 125 aa overlap); Rv1365|Q11035 (128 aa), FASTA results: opt: 393, E(): 1.4e-19, (48.8% identity in 123 aa overlap); and Rv3687c. Also weak similarity to Q9WVX8|RSBV_STRCO ANTI-SIGMA B FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa).; hypothetical protein	2150954..2151385	Mycobacterium tuberculosis H37Rv	885281
NP_216421.1	CDS	aao	NC_000962.2	2151433	2152395	R	Rv1905c, (MTCY180.13), len: 320 aa. Probable aao, D-amino acid oxidase (EC 1.4.3.3), similar to many. Equivalent to AJ000521|MLCOSL672.02|O33145 Mycobacterium leprae (320 aa), FASTA results: opt: 1541, E(): 0, (71.7% identity in 315 aa overlap); also similar to OXDD_BOVIN|P31228 d-aspartate oxidase (EC 1.4.3.1) from bos taurus (338 aa), FASTA results: opt: 461, E(): 1.1e-21, (31.8% identity in 321 aa overlap). TBparse score is 0.932; D-amino acid oxidase	complement(2151433..2152395)	Mycobacterium tuberculosis H37Rv	885504
NP_216422.1	CDS	Rv1906c	NC_000962.2	2152425	2152895	R	Rv1906c, (MTCY180.12), len: 156 aa. Conserved hypothetical protein, possibly exported protein, equivalent to Mycobacterium leprae AJ000521|MLCOSL672.01 (153 aa), FASTA scores: opt: 637, E(): 2.6e-28, (63.2% identity in 155 aa overlap). Also similar to M. tuberculosis hypothetical exported protein, Rv1352.; hypothetical protein	complement(2152425..2152895)	Mycobacterium tuberculosis H37Rv	885514
NP_216423.1	CDS	Rv1907c	NC_000962.2	2153235	2153882	R	Rv1907c, (MTCY180.11), len: 215 aa. Hypothetical unknown protein. Similar to Q50763 Ethyl methane sulphonate resistance protein from Mycobacterium tuberculosis (168 aa), FASTA scores: opt: 638, E(): 0, (69.7% identity in 152 aa overlap). Downstream of a cloned katG gene (EMBL:MTKATG). Differences are due to frameshift errors in the EMBL sequence and the use of an earlier start codon. TBparse score is 0.958.; hypothetical protein	complement(2153235..2153882)	Mycobacterium tuberculosis H37Rv	885402
NP_216424.1	CDS	katG	NC_000962.2	2153889	2156111	R	Rv1908c, (MTCY180.10), len: 740 aa. katG, catalase-peroxidase-peroxynitritase T (EC 1.11.1.6) (see citations below), HPI. FASTA results: Q57215 CATALASE-PEROXIDASE from Mycobacterium tuberculosis (740 aa) opt: 5081, E(): 0, (100% identity in 740 aa overlap). Contains peroxidases active site signature (PS00436) and ATP/GTP-binding site motif A (P-loop; PS00017). Cosmid sequence was corrected to agree with a sequencing read from the H37Rv genome. DELETIONS OR DEFECTS IN KATG GENE CAUSE ISONIAZID (INH) RESISTANCE. BELONGS TO THE PEROXIDASE FAMILY. BACTERIAL PEROXIDASE/CATALASE SUBFAMILY. KATG TRANSCRIPTION SEEMS TO BE REGULATED BY FURA|Rv1909c PRODUCT. The catalase-peroxidase activity is associated with the amino-terminal domain but no definite function has been assigned to the carboxy-terminal domain. TBparse score is 0.923.; catalase-peroxidase-peroxynitritase T KATG	complement(2153889..2156111)	Mycobacterium tuberculosis H37Rv	885638
NP_216425.1	CDS	furA	NC_000962.2	2156149	2156601	R	Rv1909c, (MTCY180.09), len: 150 aa. furA, Ferric uptake regulation protein, similar to Q48835 LEGIONELLA PNEUMOPHILA 130B (WADSWORTH) FERRIC UPTAKE REGULATION (136 aa), FASTA results: opt: 230, E(): 2.5e-09, (32.3% identity in 133 aa overlap). Also similar to Mycobacterium tuberculosis furB ferric uptake regulatory protein, Rv2359. BELONGS TO THE FUR FAMILY.; ferric uptake regulation protein furA (fur)	complement(2156149..2156601)	Mycobacterium tuberculosis H37Rv	885400
NP_216426.1	CDS	Rv1910c	NC_000962.2	2156706	2157299	R	Rv1910c, (MTCY180.08), len: 197 aa. Possible exported protein, very similar to upstream ORF MTCY180.07 (201 aa), FASTA score: E(): 0, (64.0% identity in 200 aa overlap). Also similar to Q9Z729|Y877_CHLPN PROTEIN CPN0877 from Chlamydophila pneumoniae (150 aa). TBparse score is 0.940.; hypothetical protein	complement(2156706..2157299)	Mycobacterium tuberculosis H37Rv	885897
NP_216427.1	CDS	lppC	NC_000962.2	2157382	2157987	R	Rv1911c, (MTCY180.07), len: 201 aa. Probable lipoprotein lppC, contains appropriately positioned prokaryotic membrane lipoprotein lipid attachment site (PS00013). Very similar to downstream ORF MTCY180.08 (204 aa) (although this lacks lipoprotein motif), FASTA score: opt: 831, E(): 0, (64.0% identity in 200 aa overlap). Also similar to Q9Z729|Y877_CHLPN HYPOTHETICAL PROTEIN CPN0877 from Chlamydia pneumoniae (strain CWL029) (150 aa). TBparse score is 0.940.; lipoprotein LppC	complement(2157382..2157987)	Mycobacterium tuberculosis H37Rv	885646
NP_216428.1	CDS	fadB5	NC_000962.2	2158087	2159091	R	Rv1912c, (MTCY180.06), len: 334 aa. Possible fadB5, oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases: 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35), quinone oxidoreductases (EC 1.6.5.5), and polyketide synthases, e.g. NP_104067.1|NC_002678 probable oxidoreductase from Mesorhizobium loti (308 aa); NP_464140.1|NC_003210 protein similar to oxidoreductase from Listeria monocytogenes (313 aa); NP_193889.1|NC_003075 putative NADPH quinone oxidoreductase from Arabidopsis thaliana (325 aa); NP_001880.2|NM_001889 crystallin, zeta; quinone oxidoreductase; NADPH:quinone reductase from Homo sapiens (329 aa); part 2983 to 3197 of T17410 polyketide synthase type I from Streptomyces venezuelae (3739 aa); Q53927|SCBAC20F6.16 HYDROXYACYL-CoA DEHYDROGENASE from Streptomyces coelicolor (329 aa), FASTA scores: opt: 621, E(): 2e-30, (39.5% identity in 349 aa overlap); etc. Also similar to many hypothetical Mycobacterium tuberculosis proteins including: MTCY24G1.09, MTCY13D12.11, MTCY19H9.01, MTCY24G1.03, MTCY03A2.17c, etc. Contains quinone oxidoreductase/zeta-crystallin signature (PS01162). TBparse score is 0.921.; oxidoreductase FADB5	complement(2158087..2159091)	Mycobacterium tuberculosis H37Rv	885245
NP_216429.1	CDS	Rv1913	NC_000962.2	2159191	2159943	D	Rv1913, (MTCY180.05c), len: 250 aa. Conserved hypothetical protein, slight similarity to dehydrase and beta-lactamase precursors e.g. Q02057 DEHYDRASE from Streptomyces coelicolor (297 aa), FASTA scores: opt: 184, E(): 4.3e-05, (31.6% identity in 215 aa overlap).; hypothetical protein	2159191..2159943	Mycobacterium tuberculosis H37Rv	885640
NP_216430.1	CDS	Rv1914c	NC_000962.2	2159921	2160328	R	Rv1914c, (MTCY180.04), len: 135 aa. Hypothetical unknown protein, TBparse score is 0.924; hypothetical protein	complement(2159921..2160328)	Mycobacterium tuberculosis H37Rv	885875
NP_216431.1	CDS	aceAa	NC_000962.2	2160463	2161566	D	Rv1915, (MTCY180.03c), len: 367 aa. Probable aceAa, isocitrate lyase (EC 4.1.3.1) (see citations below). Highly similar to the N-terminus of ACEA_MYCLE ISOCITRATE LYASE (EC 4.1.3.1) from Mycobacterium leprae (606 aa), FASTA results: opt: 3314, E(): 0, (86.5% identity in 572 aa overlap). Contains PS00161 Isocitrate lyase signature. Although this ORF and the downstream ORF representing the C-terminal half of aceA could be joined by a frameshift, no error is apparent in the cosmid, or in a seqencing read from the genome of H37Rv. As the downstream ORF has a RBS and transcriptional start immediately following the stop of this ORF, it is possible that they are expressed as two separate modules. In Mycobacterium tuberculosis strain CDC1551, aceA exists as a single gene, MT1966: the corresponding protein has been purified experimentally and seems have an active isocitrate lyase activity (see Honer et al., 1999). For Mycobacterium tuberculosis strain H37Rv, immunoblot assay didn't detect AceAa or AceAb products (see Honer et al., 1999) but mRNA of AceAa|Rv1915 has been detected (see Betts et al., 2002); so AceAb|Rv1916 could be a pseudogene.; isocitrate lyase	2160463..2161566	Mycobacterium tuberculosis H37Rv	885639
NP_216432.1	CDS	aceAb	NC_000962.2	2161566	2162762	D	Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase	2161566..2162762	Mycobacterium tuberculosis H37Rv	885383
YP_177655.1	CDS	PPE34	NC_000962.2	2162932	2167311	R	Rv1917c, (MTV050.01c-MTCY180.01), len: 1459 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, MPTR subfamily (see citation below). Similar to MTCY28.16, MTCY13E10.17, MTCY63.10, MTV004.05 , MTCY98.24, MTCY6G11.05, etc. C-terminus is identical to Q50471. Unknown Mycobacterium tuberculosis protein (693 aa), FASTA results: opt: 2635, E(): 0, (99.7% identity in 391 aa overlap). Start changed since original submission (+23 aa). Thougth to be surface exposed, cell-wall associated.; PPE family protein	complement(2162932..2167311)	Mycobacterium tuberculosis H37Rv	885362
YP_177850.1	CDS	PPE35	NC_000962.2	2167649	2170612	R	Rv1918c, (MTV050.02c), len: 987 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to MTCY28.16|Z95890 Mycobacterium tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404, E(): 0, (65.6% identity in 1058 aa overlap). Also similar to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23, MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36, MTCY180.01, etc.; PPE family protein	complement(2167649..2170612)	Mycobacterium tuberculosis H37Rv	885506
NP_216435.1	CDS	Rv1919c	NC_000962.2	2171061	2171525	R	Rv1919c, (MTV050.03c), len: 154 aa. Conserved hypothetical protein, shows weak similarity to several major pollen antigens e.g. Z72431|BVGC25_1 MAJOR ALLERGEN BET V 1 from Betula verrucosa (160 aa), FASTA scores: opt: 133, E(): 0.012, (26.8% identity in 149 aa overlap). Also shows some similarity to Rv2574|MTCY227.27C Hypothetical protein from Mycobacterium tuberculosis (167 aa), (27.4% identity in 124 aa overlap).; hypothetical protein	complement(2171061..2171525)	Mycobacterium tuberculosis H37Rv	885876
NP_216436.1	CDS	Rv1920	NC_000962.2	2171623	2172486	D	Rv1920, (MTV050.04), len: 287 aa. Probable membrane protein, similar to AL0215|SC10A5.04 putative membrane protein from Streptomyces coelicolor cosmid 10A5 (295 aa), FASTA scores: opt: 292, E(): 3.6e-13, (31.3% identity in 243 aa overlap). Also weakly similar to several Mycobacterial putative proteins with unknown function e.g. Rv0502, Rv1428c, U00018_22 Mycobacterium leprae cosmid B2168.; hypothetical protein	2171623..2172486	Mycobacterium tuberculosis H37Rv	885416
NP_216437.1	CDS	lppF	NC_000962.2	2172524	2173795	R	Rv1921c, (MTCY09F9.43-MTV050.05c), len: 423 aa. Probable lppF, conserved lipoprotein, similar to G403173 lipoprotein precursor (fragment) from Rhodococcus erythropolis (225 aa), fasta scores: opt: 364, E(): 9.2e-19, (41.9% identity in 148 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LppF	complement(2172524..2173795)	Mycobacterium tuberculosis H37Rv	885917
NP_216438.1	CDS	Rv1922	NC_000962.2	2174067	2175182	D	Rv1922, (MTCY09F9.42c), len: 371 aa. Probable conserved lipoprotein, possibly peptidase (EC 3.4.-.-) similar to many peptidases, e.g. P15555|DAC_STRSQ D-alanyl-D-alanine carboxypeptidase from Streptomyces sp. (406 aa), FASTA scores: opt: 382, E(): 3.1e-17, (28.0% identity in 379 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein	2174067..2175182	Mycobacterium tuberculosis H37Rv	885918
NP_216439.1	CDS	lipD	NC_000962.2	2175173	2176513	D	Rv1923, (MTCY09F9.41c), len: 446 aa. Probable lipD, hydrolase lipase (EC 3.1.-.-), similar to esterases and beta-lactamases e.g. G151214 esterase, (389 aa), fasta scores: opt: 569, E(): 5.4e-29, (33.7% identity in 401 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497, Rv2463, Rv3775, etc.; lipase LIPD	2175173..2176513	Mycobacterium tuberculosis H37Rv	885910
NP_216440.1	CDS	Rv1924c	NC_000962.2	2176550	2176930	R	Rv1924c, (MTCY09F9.40), len: 126 aa. Hypothetical unknown protein.; hypothetical protein	complement(2176550..2176930)	Mycobacterium tuberculosis H37Rv	885352
NP_216441.1	CDS	fadD31	NC_000962.2	2177087	2178949	D	activates fatty acids by binding to coenzyme A; putative fatty-acid--CoA ligase	2177087..2178949	Mycobacterium tuberculosis H37Rv	885200
NP_216442.1	CDS	mpt63	NC_000962.2	2178957	2179436	R	Rv1926c, (MT1977, MTCY09F9.38), len: 159 aa. mpt63 (alternate gene name: mpb63), immunogenic protein (see citations below), identical to MPT63|MPB63 from Mycobacterium bovis (159 aa). Exported protein containing a N-terminal signal sequence: see notes below about proteomics.; mpb63; immunogenic protein MPT63 (antigen MPT63/MPB63) (16 kDa immunoprotective extracellular protein)	complement(2178957..2179436)	Mycobacterium tuberculosis H37Rv	885334
NP_216443.1	CDS	Rv1927	NC_000962.2	2179673	2180446	D	Rv1927, (MTCY09F9.37c), len: 257 aa. Conserved hypothetical protein, similar to SCG11A.10c|AL133210 hypothetical protein from Streptomyces coelicolor (252 aa), FASTA scores: opt: 729, E(): 0, (48.3% identity in 238 aa overlap). Slight similarity with P54543|YQJF_BACSU hypothetical 23.9 kDa protein from Bacillus subtilis (209 aa), FASTA scores, opt: 230, E(): 2.8e-08, (28.0% identity in 164 aa overlap).; hypothetical protein	2179673..2180446	Mycobacterium tuberculosis H37Rv	885912
NP_216444.1	CDS	Rv1928c	NC_000962.2	2180450	2181217	R	Rv1928c, (MTCY09F9.36), len: 255 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to others e.g. NP_228109.1|NC_000853 oxidoreductase (short chain dehydrogenase/reductase family) from Thermotoga maritima (257 aa); T41116 short chain dehydrogenase from Schizosaccharomyces pombe (261 aa); P87219|SOU1_CANAL SORBITOL UTILIZATION PROTEIN (SDR FAMILY) from Candida albicans (281 aa); P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa), FASTA scores: opt: 541, E(): 1.2e-27, (37.5% identity in 251 aa overlap); etc. Also similar to many mycobacterial tuberculosis proteins e.g. Rv1350, Rv0927c, Rv2002, Rv0769, Rv2766c, etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short chain dehydrogenase	complement(2180450..2181217)	Mycobacterium tuberculosis H37Rv	885331
NP_216445.1	CDS	Rv1929c	NC_000962.2	2181262	2181906	R	Rv1929c, MTCY09F9.35, len: 214 aa. Conserved hypothetical protein, similar to SC4G6.14|AL096884 hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 416, E(): 2.4e-22, (39.8% identity in 206 aa overlap).; hypothetical protein	complement(2181262..2181906)	Mycobacterium tuberculosis H37Rv	885630
NP_216446.1	CDS	Rv1930c	NC_000962.2	2181918	2182442	R	Rv1930c, MTCY09F9.34, len: 174 aa. Conserved hypothetical protein, similar to SC5F2A.30|AL049587 hypothetical protein from Streptomyces coelicolor (211 aa), FASTA scores: opt: 307, E(): 2.8e-13, (54.8% identity in 84 aa overlap). Some similarity to M. tuber culosis hypothetical protein Rv0052|MTCY21D4.15 (43% identity in 93 aa overlap).; hypothetical protein	complement(2181918..2182442)	Mycobacterium tuberculosis H37Rv	885344
NP_216447.1	CDS	Rv1931c	NC_000962.2	2182460	2183239	R	Rv1931c, (MTCY09F9.33), len: 259 aa. Probable transcriptional regulatory protein. Similarity in C-terminal half to transcriptional activators e.g. Q43970 ARAC-LIKE PROTEIN (227 aa), FASTA scores: opt: 238, E(): 7.1e-07, (42.4% identity in 92 aa overlap). Similar to many probable transcription regulators in Streptomyces e.g. AL049587|SC5F2A.29 Streptomyces coelicolor (325 aa), FASTA scores: opt: 387, E(): 3.2e-16, (34.4% identity in 259 aa overlap).; transcriptional regulatory protein	complement(2182460..2183239)	Mycobacterium tuberculosis H37Rv	885437
NP_216448.1	CDS	tpx	NC_000962.2	2183372	2183869	D	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase	2183372..2183869	Mycobacterium tuberculosis H37Rv	885357
NP_216449.1	CDS	fadE18	NC_000962.2	2183866	2184957	R	Rv1933c, (MTCY09F9.31), len: 363 aa. Probable fadE18, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. CAB61609.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (362 aa); NP_421282.1|NC_002696 acyl-CoA dehydrogenase family protein from Caulobacter crescentus (344 aa); ACDS_RAT|P15651 short-chain specific acyl-CoA dehydrogenase from Rattus norvegicus (Rat) (412 aa), fasta scores: opt: 239, E(): 2.1e-08, (28.4% identity in 331 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. N-terminus of fadE22 (721 aa); fadE33 (318 aa); N-terminus of fadE34 (711 aa); etc. COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE18	complement(2183866..2184957)	Mycobacterium tuberculosis H37Rv	885394
NP_216450.1	CDS	fadE17	NC_000962.2	2184959	2186188	R	Rv1934c, (MTCY09F9.30), len: 409 aa. Probable fadE17, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to ACD_MYCLE|P46703 acyl-CoA dehydrogenase from Mycobacterium leprae (389 aa), FASTA scores: opt: 414, E(): 2.6e-19, (28.3% identity in 407 aa overlap). Also similar to many e.g. NP_249713.1|NC_002516 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (381 aa); NP_420614.1|NC_002696 acyl-CoA dehydrogenase family protein from Caulobacter crescentus (355 aa); CAB61610.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (393 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. fadE30 (385 aa); fadE31 (377 aa); C-terminus of fadE34 (711 aa); etc. COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE17	complement(2184959..2186188)	Mycobacterium tuberculosis H37Rv	885379
NP_216451.1	CDS	echA13	NC_000962.2	2186203	2187159	R	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	complement(2186203..2187159)	Mycobacterium tuberculosis H37Rv	885240
NP_216452.1	CDS	Rv1936	NC_000962.2	2187384	2188493	D	Rv1936, (MTCY09F9.28c), len: 369 aa. Possible monooxygenase (EC 1.-.-.-), similar to LXA2_PHOLU|P23146 alkanal monooxygenase alpha chain (362 aa), FASTA scores: opt: 196, E(): 6.3e-06, (22.3% identity in 373 aa overlap). Also similar to many other Mycobacterium tuberculosis hypothetical oxidoreductases and monooxygenases e.g. Rv0953c, Rv0791c, Rv0132c, etc.; monooxygenase	2187384..2188493	Mycobacterium tuberculosis H37Rv	885882
NP_216453.1	CDS	Rv1937	NC_000962.2	2188496	2191015	D	Rv1937, (MTCY09F9.27c), len: 839 aa. Possible oxygenase (EC 1.-.-.-), similar in N-terminus to N-terminal part (approx. 350 aa) of dioxygenases (including ring-hydroxylating dioxygenase electron transfer components) and monooxygenases, e.g. AAC34815.1|AF071556 anthranilate dioxygenase reductase from Acinetobacter sp. (343 aa); AAK52291.1|AY026914|AntC putative anthranilate dioxygenase reductase from Pseudomonas putida (340 aa); AAF63450.1|AF218267_7|AF218267 benzoate dioxygenase / ferredoxin reductase from Pseudomonas putida (336 aa); P23101|XYLZ_PSEPU toluate 1,2-dioxygenase electron transfer component [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE (EC 1.18.1.3)] from Pseudomonas putida plasmid TOL pWW0 (336 aa), FASTA scores: opt: 700, E(): 0, (34.3% identity in 335 aa overlap); S23479 probable benzoate 1,2-dioxygenase (EC 1.14.12.10) reductase component benC from Acinetobacter calcoaceticus (338 aa); AAC45294.1|U81594 soluble methane monooxygenase protein C from Methylocystis sp. (343 aa); P22868|MEMC_METCA METHANE MONOOXYGENASE COMPONENT C from Methylococcus capsulatus (348 aa); etc. Also similar in part to Mycobacterium tuberculosis hypothetical electron transfer proteins Rv3554, Rv3571, etc. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.; oxygenase	2188496..2191015	Mycobacterium tuberculosis H37Rv	885433
NP_216454.1	CDS	ephB	NC_000962.2	2191027	2192097	D	Rv1938, (MTCY09F9.26c), len: 356 aa. Probable ephB, epoxide hydrolase (EC 3.3.2.3) (see citation below), similar to many e.g. G1109600 ATSEH (EC 3.3.2.3) (321 aa), FASTA scores: opt: 442, E(): 1.2e-21 (33.1% identity in 356 aa overlap); etc. Also similar to many other M. tuberculosis hypothetical epoxide hydrolases e.g. Rv3617, Rv3670, Rv0134, etc.; epoxide hydrolase EphB	2191027..2192097	Mycobacterium tuberculosis H37Rv	885392
NP_216455.1	CDS	Rv1939	NC_000962.2	2192094	2192609	D	Rv1939, (MTCY09F9.25c), len: 171 aa. Probable oxidoreductase (EC 1.-.-.-), similar to NP_302637.1|NC_002677 probable oxidoreductase from Mycobacterium leprae (162 aa) Also similar to NTAB_CHELE|P54990 nitrilotriacetate monooxygenase component from Chelatobacter heintzii (322 aa), fasta scores: opt: 269, E(): 5.3e-11, (33.1% identity in 151 aa overlap). And similar to Mycobacterium tuberculosis probable monooxygenase components Rv0246, Rv3567, and to a lesser extent, Rv3007c.; oxidoreductase	2192094..2192609	Mycobacterium tuberculosis H37Rv	885488
YP_177851.1	CDS	ribA1	NC_000962.2	2192606	2193667	D	Rv1940, (MTCY09F9.24c), len: 353 aa. Probable ribA1, Riboflavin biosynthesis protein (EC 3.5.4.25), similar to GCH2_BACSU|P17620 gtp cyclohydrolase ii (EC 3.5.4.25) (398 aa), FASTA scores: opt: 682, E(): 0, (37.7% identity in 363 aa overlap), also similar to Rv1415|MTCY21B4.33|ribA2 (428 aa) (45.4% identity in 368 aa overlap). Note that previously known as ribA.; ribA; riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II)	2192606..2193667	Mycobacterium tuberculosis H37Rv	885621
NP_216457.1	CDS	Rv1941	NC_000962.2	2193664	2194434	D	Rv1941, (MTCY09F9.23c), len: 256 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases, generally belonging to SDR family, e.g. NP_299015.1|NC_002488 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase from Xylella fastidiosa (255 aa); NP_250340.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (253 aa); NP_106890.1|NC_002678 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from Mesorhizobium loti (374 aa) (has its N-terminus longter); P50197|LINC_PSEPA 2,5-dichloro-2,5-cyclohexadiene-1,4-dehydrogenase from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 aa), FASTA scores: opt: 529, E(): 5.7e-25, (40.6% identity in 251 aa overlap); etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short-chain type dehydrogenase/reductase	2193664..2194434	Mycobacterium tuberculosis H37Rv	885622
NP_216458.1	CDS	Rv1942c	NC_000962.2	2194644	2194973	R	Rv1942c, (MTCY09F9.22), len: 109 aa. Conserved hypothetical protein, shows some similarity to Q10867|MTCY39.28|Rv1991 hypothetical 12.3 kDa protein (114 aa), FASTA scores: opt: 117, E(): 0.021, (24. 5% identity in 110 aa overlap) also P33645|CHPA_ECOLI pemk-like protein 1 (mazf protein) from Escherichia coli (111 aa), FASTA scores: opt: 104, E(): 0.18, (29.1% identity in 110 aa overlap). Also similar to Mycobacterium tuberculosis Rv0659c (102 aa) (32.7% identity in 101 aa overlap); Rv1102c (33.3% identity in 93 aa overlap) and Rv1495.; hypothetical protein	complement(2194644..2194973)	Mycobacterium tuberculosis H37Rv	885606
NP_216459.1	CDS	Rv1943c	NC_000962.2	2194970	2195347	R	Rv1943c, (MTCY09F9.21), len: 125 aa. Conserved hypothetical protein, showing some similarity with Rv1946c|MTCY09F9.18|lppG possible conserved lipoprotein from Mycobacterium tuberculosis (150 aa), FASTA score: (71.4% identity in 28 aa overlap).; hypothetical protein	complement(2194970..2195347)	Mycobacterium tuberculosis H37Rv	885605
NP_216460.1	CDS	Rv1944c	NC_000962.2	2195344	2195934	R	Rv1944c, (MTCY09F9.20), len: 196 aa. Conserved hypothetical protein, similar to C-terminal part of SCE20.29|AL136058|CAB65585.1 hypothetical protein from Streptomyces coelicolor (338 aa), BLASTP scores, Identities = 37/131 (28%), Positives = 51/131 (38%).; hypothetical protein	complement(2195344..2195934)	Mycobacterium tuberculosis H37Rv	885884
NP_216461.1	CDS	Rv1945	NC_000962.2	2195989	2197353	D	Rv1945, (MTCY09F9.19c), len: 454 aa. Member of Mycobacterium tuberculosis REP13E12 repeat family. Similar to several others, best with Rv1148c|Z95584|MTCI65.15 (482 aa), FASTA score: opt: 2954, E(): 0, (97.1% identity in 454 aa overlap). Contains possible helix-turn-helix motif at aa 74-95 (+2.90 SD).; hypothetical protein	2195989..2197353	Mycobacterium tuberculosis H37Rv	885980
NP_216462.1	CDS	lppG	NC_000962.2	2197508	2197960	R	Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG, conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (125 aa), FASTA score: (71.4% identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein	complement(2197508..2197960)	Mycobacterium tuberculosis H37Rv	885979
NP_216463.1	CDS	Rv1947	NC_000962.2	2198024	2198425	D	Rv1947, (MTCY09F9.17c), len: 133 aa. Hypothetical unknown protein; hypothetical protein	2198024..2198425	Mycobacterium tuberculosis H37Rv	885976
NP_216464.1	CDS	Rv1948c	NC_000962.2	2198714	2199064	R	Rv1948c, (MTCY09F9.16), len: 116 aa. Hypothetical unknown protein; hypothetical protein	complement(2198714..2199064)	Mycobacterium tuberculosis H37Rv	885975
NP_216465.1	CDS	Rv1949c	NC_000962.2	2199075	>2200034	R	Rv1949c, (MTCY09F9.15), len: 319 aa. Conserved hypothetical protein, partial ORF. Rv1949c and Rv1950c|MTCY09F9.14 are similar but frameshifted with respect to Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kd protein (323 aa), FASTA scores: opt: 459, E(): 2.8e-16, (54.8% identity in 157 aa overlap). Cosmid sequence appears to be correct, genomic sequence is also frameshifted in Mycobacterium bovis strain AF2122/97. Similar to Mycobacterium tuberculosis hypothetical proteins: Rv2542, Rv2077c, Rv2797c, Rv0963c, etc.; hypothetical protein	complement(2199075..>2200034)	Mycobacterium tuberculosis H37Rv	885974
NP_216466.1	CDS	Rv1950c	NC_000962.2	2199998	2200189	R	Rv1950c, (MTCY09F9.14), len: 63 aa. Conserved hypothetical protein, partial ORF. Highly similar to N-terminus of Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kDa protein (323 aa), FASTA scores: opt: 280, E(): 1.2 e-16, (71.7% identity in 53 aa overlap) but homology continues in different frame ie MTCY09F9.15, cosmid sequence appears to be correct, genomic sequence is also frameshifted in Mycobacterium bovis strain AF2122/97.; hypothetical protein	complement(2199998..2200189)	Mycobacterium tuberculosis H37Rv	885973
NP_216467.1	CDS	Rv1951c	NC_000962.2	2200190	2200486	R	Rv1951c, (MTCY09F9.13), len: 98 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv2541 (135 aa) (40.9% identity in 88 aa overlap).; hypothetical protein	complement(2200190..2200486)	Mycobacterium tuberculosis H37Rv	885972
NP_216468.1	CDS	Rv1952	NC_000962.2	2200726	2200941	D	Rv1952, (MTCY09F9.12c), len: 71 aa. Conserved hypothetical protein. Some similarity to P55510|Y4JJ_RHISN PUTATIVE PLASMID STABILITY PROTEIN (85 aa), FASTA scores: opt: 127, E(): 0.00096, (42.5% identity in 73 aa overlap).; hypothetical protein	2200726..2200941	Mycobacterium tuberculosis H37Rv	885971
NP_216469.1	CDS	Rv1953	NC_000962.2	2200938	2201249	D	Rv1953, (MTCY09F9.11c), len: 103 aa. Conserved hypothetical protein. Some similarity to O33827 PLASMID STABILITY-LIKE PROTEIN from Thiobacillus ferrooxidans (143 aa), FASTA scores: opt: 170, E(): 3.5e-06, (45.3% identity in 75 aa overlap).; hypothetical protein	2200938..2201249	Mycobacterium tuberculosis H37Rv	885970
NP_216470.1	CDS	Rv1954c	NC_000962.2	2201223	2201744	R	Rv1954c, (MTCY09F9.10), len: 173 aa. Hypothetical unknown protein, end overlaps next ORF upstream, Rv1955 (MTCY09F9.09c).; hypothetical protein	complement(2201223..2201744)	Mycobacterium tuberculosis H37Rv	885967
NP_216471.1	CDS	Rv1955	NC_000962.2	2201584	2202096	D	Rv1955, (MTCY09F9.09c), len: 170 aa. Hypothetical unknown protein, start overlaps another ORF, Rv1954c (MTCY09F9.10).; hypothetical protein	2201584..2202096	Mycobacterium tuberculosis H37Rv	885966
NP_216472.1	CDS	Rv1956	NC_000962.2	2202138	2202587	D	Rv1956, (MTCY09F9.08c), len: 149 aa. Possible transcriptional regulatory protein, contains probable helix-turn-helix motif at aa 52-73 (+4.78 SD).; transcriptional regulatory protein	2202138..2202587	Mycobacterium tuberculosis H37Rv	885964
NP_216473.1	CDS	Rv1957	NC_000962.2	2202584	2203129	D	Rv1957, (MTCY09F9.07c), len: 181 aa. Hypothetical unknown protein.; hypothetical protein	2202584..2203129	Mycobacterium tuberculosis H37Rv	885961
NP_216474.1	CDS	Rv1958c	NC_000962.2	2203018	2203632	R	Rv1958c, (MTCY09F9.06), len: 204 aa. Hypothetical unknown protein, questionable ORF; hypothetical protein	complement(2203018..2203632)	Mycobacterium tuberculosis H37Rv	885960
NP_216475.1	CDS	Rv1959c	NC_000962.2	2203681	2203977	R	Rv1959c, (MTCY09F9.05), len: 98 aa. Conserved hypothetical protein, similar to other hypothetical plasmid proteins e.g. AL117189|YPCD1.08 from Yersinia pestis (99 aa), FASTA scores: opt: 162, E(): 7.3e-05, (33.0% identity in 91 aa overlap); also some similarity to E145339 hypothetical protein (103 aa), FASTA scores: opt: 142, E(): 0.0003, (33.0% identity in 91 aa overlap).; hypothetical protein	complement(2203681..2203977)	Mycobacterium tuberculosis H37Rv	885958
NP_216476.1	CDS	Rv1960c	NC_000962.2	2203974	2204225	R	Rv1960c, (MTCY09F9.04), len: 83 aa. Conserved hypothetical protein, similar to O85269|AF102990|AF102990_51 hypothetical protein of Yersinia enterocolitica (80 aa), FASTA scores: opt: 149, E(): 0.00037, (42 .1% identity in 57 aa overlap).; hypothetical protein	complement(2203974..2204225)	Mycobacterium tuberculosis H37Rv	885957
NP_216477.1	CDS	Rv1961	NC_000962.2	2204212	2204706	D	Rv1961, MTCY09F9.03c, len: 164 aa. Hypothetical unknown protein.; hypothetical protein	2204212..2204706	Mycobacterium tuberculosis H37Rv	885954
NP_216478.1	CDS	Rv1962c	NC_000962.2	2204866	2205273	R	Rv1962c, (MTCY09F9.02), len: 135 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv3408|MTCY78.20c (133 aa) (36.2% identity in 138 aa overlap); and Rv3384c (130 aa) (43.1% identity in 130 aa overlap); hypothetical protein	complement(2204866..2205273)	Mycobacterium tuberculosis H37Rv	885952
NP_216479.1	CDS	mce3R	NC_000962.2	2205582	2206802	R	Rv1963c, (MTV051.01c-MTCY09F9.01), len: 406 aa. Probable mce3R, negative transcriptional regulatory protein, tetR family (see citation below); similar to several transcriptional regulator e.g. AL049485|SC6A5.30 Streptomyces coelicolor cosmid 6 A (404 aa), FASTA scores: opt: 319, E(): 6.4e-13, (29.5% identity in 373 aa overlap); and Z84498|MTCY9F9_1 (259 aa), FASTA scores: opt: 208, E(): 1.6e-07, (100.0% identity in 32 aa overlap). Contains probable helix-turn-helix at aa 36-57 (+4.23 SD) and two tet-R family signatures.; transcriptional repressor (probably TETR-family) MCE3R	complement(2205582..2206802)	Mycobacterium tuberculosis H37Rv	885950
NP_216480.1	CDS	yrbE3A	NC_000962.2	2207700	2208497	D	Rv1964, (MTV051.02), len: 265 aa. yrbE3A, hypothetical unknown integral membrane protein, part of mce3 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa), O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa), Rv3501c|MTV023.08c|yrbE4A (254 aa), etc. Also highly similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. AAD24544.1|AF116213|YrbE1A from Mycobacterium leprae (112 aa); P45392|YRBE_ECOLI from Escherichia coli (260 aa), FASTA scores: opt: 893, E(): 0, (51.4% identity in 253 aa overlap); etc. TBparse score is 0.889. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al., 2002).; integral membrane protein YrbE3A	2207700..2208497	Mycobacterium tuberculosis H37Rv	885948
NP_216481.1	CDS	yrbE3B	NC_000962.2	2208507	2209322	D	Rv1965, (MTV051.03), len: 271 aa. yrbE4B, hypothetical unknown integral membrane protein, part of mce3 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa), FASTA scores: opt: 937, E(): 0, (54.3% identity in 254 aa overlap); O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. AAD24545.1|AF116213|YrbE1B from Mycobacterium leprae (106 aa); P45392|YRBE_ECOLI HYPOTHETICAL 27.9 kDa PROTEIN from Escherichia coli (260 aa), FASTA scores: opt: 218, E(): 1.2e-07, (24.1% identity in 245 aa overlap); etc. TBparse score is 0.881. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al., 2002).; integral membrane protein YrbE3b	2208507..2209322	Mycobacterium tuberculosis H37Rv	885947
YP_177852.1	CDS	mce3A	NC_000962.2	2209327	2210604	D	Rv1966, (MTV051.04), len: 425 aa. mce3A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa); NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa); CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa); etc. Contains a possible N-terminal signal sequence or membrane anchor. TBparse score is 0.897. Note that previously known as mce3. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al., 2002).; mce3; MCE-family protein MCE3A	2209327..2210604	Mycobacterium tuberculosis H37Rv	885944
NP_216483.1	CDS	mce3B	NC_000962.2	2210601	2211629	D	Rv1967, (MTV051.05), len: 342 aa. mce3B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); etc. Also similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); CAC12797.1|AL445327 putative secreted protein from Streptomyces coelicolor (354 aa); etc. Contains a possible N-terminal signal sequence or membrane anchor. TBparse score is 0.872. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al., 2002).; MCE-family protein MCE3B	2210601..2211629	Mycobacterium tuberculosis H37Rv	885943
NP_216484.1	CDS	mce3C	NC_000962.2	2211626	2212858	D	Rv1968, (MTV051.06), len: 410 aa. mce3C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); etc. Also similar to others e.g. CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); etc. Contains a possible N-terminal signal sequence or membrane anchor. TBparse score is 0.875. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al., 2002).; MCE-family protein MCE3C	2211626..2212858	Mycobacterium tuberculosis H37Rv	885942
NP_216485.1	CDS	mce3D	NC_000962.2	2212855	2214126	D	Rv1969, (MTV051.07), len: 423 aa. mce3D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Contains a possible N-terminal signal sequence or membrane anchor. TBparse score is 0.872. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al., 2002).; MCE-family protein MCE3D	2212855..2214126	Mycobacterium tuberculosis H37Rv	885940
NP_216486.1	CDS	lprM	NC_000962.2	2214123	2215256	D	Rv1970, (MTV051.08), len: 377 aa. Possible lprM (alternate gene name: mce3E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa); O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa); CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa); etc. Contains possible N-terminal signal sequence or membrane anchor and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.880. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al., 2002).; mce3E; MCE-family lipoprotein LprM	2214123..2215256	Mycobacterium tuberculosis H37Rv	885939
NP_216487.1	CDS	mce3F	NC_000962.2	2215257	2216570	D	Rv1971, (MTV051.09), len: 437 aa. mce3F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa), O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa); CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa); etc. Contains a possible N-terminal signal sequence or membrane anchor. TBparse score is 0.881. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al., 2002).; MCE-family protein MCE3F	2215257..2216570	Mycobacterium tuberculosis H37Rv	885938
NP_216488.1	CDS	Rv1972	NC_000962.2	2216592	2217167	D	Rv1972, (MTV051.10), len: 191 aa. Probable conserved Mce-associated membrane protein. Probably part of mce3 operon. Similar to several Mycobacterium tuberculosis proteins e.g. Rv1363c|Z75555|MTCY02B10.27C (261 aa), FASTA scores: opt: 342, E(): 1.2e-15, (31.8% identity in 195 aa overlap); Rv1362c, Rv0177 (near Mce operon 1), etc. Has hydrophobic stretch at aa 20-40. TBparse score is 0.896.; mce associated membrane protein	2216592..2217167	Mycobacterium tuberculosis H37Rv	885937
NP_216489.1	CDS	Rv1973	NC_000962.2	2217164	2217646	D	Rv1973, (MTV051.11), len: 160 aa. Possible conserved Mce-associated membrane protein. Probably part of mce3 operon. Similar to several other proteins from Mycobacterium tuberculosis e.g. Rv1362c|Z75555|MTCY02B10.26C (220 aa), FASTA scores: opt: 378, E(): 2.8e-19, (50.0% identity in 128 aa overlap); Rv1363c; Rv0177 (near Mce operon 1); etc. Contains possible N-terminal signal sequence or membrane anchor. TBparse score is 0.863.; MCE associated membrane protein	2217164..2217646	Mycobacterium tuberculosis H37Rv	885936
NP_216490.1	CDS	Rv1974	NC_000962.2	2217659	2218036	D	Rv1974, (MTV051.12), len: 125 aa. Probable conserved membrane protein, weakly similar to other Mycobacterium tuberculosis proteins e.g. Rv1271c|Z77137|MTCY50.11 (113 aa), FASTA scores: opt: 98, E(): 1.4, (24.5% identity in 110 aa overlap); Rv1804c; Rv1690. Has possible signal peptide or transmembrane stretch from aa 12-30. TBparse score is 0.915.; hypothetical protein	2217659..2218036	Mycobacterium tuberculosis H37Rv	885935
NP_216491.1	CDS	Rv1975	NC_000962.2	2218052	2218717	D	Rv1975, (MTV051.13), len: 221 aa. Conserved hypothetical protein, showing some similarity to AJ251435 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (193 aa). TBparse score is 0.919.; hypothetical protein	2218052..2218717	Mycobacterium tuberculosis H37Rv	885934
NP_216492.1	CDS	Rv1976c	NC_000962.2	2218844	2219251	R	Rv1976c, (MTV051.14), len: 135 aa. Conserved hypothetical protein, similar to SC1C3.03c|AL023702 hypothetical protein from Streptomyces coelicolor (125 aa), FASTA score: opt: 223, E(): 3.3e-08, (39.6% identity in 111 aa overlap). TBparse score is 0.891.; hypothetical protein	complement(2218844..2219251)	Mycobacterium tuberculosis H37Rv	885933
NP_216493.1	CDS	Rv1977	NC_000962.2	2219754	2220800	D	Rv1977, (MTV051.15), len: 348 aa. Conserved hypothetical protein, similar to SCC123.20|AL136518 hypothetical protein from Streptomyces coelicolor (402 aa), BLASTP scores: Score = 311 bits (789), Expect = 5e-84 Identities = 156/316 ( 49%), Positives = 212/316 (66%); and PCC6803|D90907_31 Synechocystis sp. (303 aa), FASTA scores: opt: 533, E(): 4.7e- 29, (38.5% identity in 275 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. TBparse score is 0.898.; hypothetical protein	2219754..2220800	Mycobacterium tuberculosis H37Rv	885931
NP_216494.1	CDS	Rv1978	NC_000962.2	2220908	2221756	D	Rv1978, (MTV051.16), len: 282 aa. Conserved hypothetical protein, similar to several hypothetical proteins and methyltransferases e.g. X86780|SHGCPIR.15 methyltransferase from S. hygroscopicus (211 aa), FASTA scores: opt: 151, E(): 0.0072, (30.6% identity in 121 aa overlap). TBparse score is 0.933.; hypothetical protein	2220908..2221756	Mycobacterium tuberculosis H37Rv	885928
NP_216495.1	CDS	Rv1979c	NC_000962.2	2221719	2223164	R	(MTCY39.40-MTV051.17c), len: 481 aa. Possible permease, APC family possibly involved in transport of amino acid, showing some similarity to other permeases. Also similar to MTCY39.19 from Mycobacterium tuberculosis (28.2% identity in 277 aa overlap). Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.; permease	complement(2221719..2223164)	Mycobacterium tuberculosis H37Rv	885819
NP_216496.1	CDS	mpt64	NC_000962.2	2223343	2224029	R	Rv1980c, (MT2032, MTCY39.39), len: 228 aa. mpt64 (alternate gene name: mpb64), immunogenic protein (alternate gene name: mpb64) (see citations below), identical to MPT64|MPB64 from Mycobacterium bovis (228 aa). Similar to Rv3036c|MTV012.51c from Mycobacterium tuberculosis. Exported protein containing a N-terminal signal sequence: see notes below about proteomics.; mpb64; immunogenic protein MPT64 (antigen MPT64/MPB64)	complement(2223343..2224029)	Mycobacterium tuberculosis H37Rv	885925
YP_177853.1	CDS	nrdF1	NC_000962.2	2224220	2225188	R	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta	complement(2224220..2225188)	Mycobacterium tuberculosis H37Rv	885923
NP_216498.1	CDS	Rv1982c	NC_000962.2	2225413	2225832	R	Rv1982c, (MTCY39.37), len: 139 aa. Conserved hypothetical protein. BELONGS TO THE UPF0110 FAMILY. Similar to Rv0624|Z92772|MTY20H10.05 from Mycobacterium tuberculosis (131 aa), FASTA scores: opt: 288, E(): 4.1e-14, (40.2% identity in 127 aa overlap); also similar to Rv0624, Rv2759c, and Rv0609; hypothetical protein	complement(2225413..2225832)	Mycobacterium tuberculosis H37Rv	885816
YP_177854.1	CDS	PE_PGRS35	NC_000962.2	2226244	2227920	D	Rv1983, (MTCY39.36c), len: 558 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). Similar to other PE proteins e.g. Rv0977, etc. Contains PS00141 Eukaryotic and viral aspartyl proteases active site.; PE-PGRS family protein	2226244..2227920	Mycobacterium tuberculosis H37Rv	885921
NP_216500.1	CDS	cfp21	NC_000962.2	2227908	2228561	R	Rv1984c, (MTCY39.35), len: 217 aa. cfp21, probable cutinase precursor with N-terminal signal sequence (EC 3.1.1.-), similar to P41744|CUTI_ALTBR cutinase precursor from Alternaria brassicicola (209 aa), FASTA scores: opt: 283, E(): 2.2e-11, (32.6% identity in 193 aa overlap). Also similar to Mycobacterium tuberculosis proteins e.g. Rv3452, Rv3451, Rv2301, Rv1758, Rv3724. BELONGS TO THE CUTINASE FAMILY.; cutinase precursor CFP21	complement(2227908..2228561)	Mycobacterium tuberculosis H37Rv	885813
NP_216501.1	CDS	Rv1985c	NC_000962.2	2228991	2229902	R	specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein	complement(2228991..2229902)	Mycobacterium tuberculosis H37Rv	885818
NP_216502.1	CDS	Rv1986	NC_000962.2	2230011	2230610	D	Rv1986, (MTCY39.33c), len: 199 aa. Probable conserved integral membrane protein, LysE family possibly involved in transport of Lysine, similar to P11667|YGGA_ECOLI hypothetical 23.2 kDa protein in sbm-fba intergenic region (211 aa), FASTA scores: opt: 379, E(): 1.5e-19, (37.3% identity in 185 aa overlap); and Q11154|Rv0488 HYPOTHETICAL 20.9 kDa PROTEIN from M. tuberculosis (201 aa), FASTA scores: opt: 784, E(): 0, (63.4% identity in 186 aa overlap). BELONGS TO THE LYSE/YGGA FAMILY.; integral membrane protein	2230011..2230610	Mycobacterium tuberculosis H37Rv	885635
NP_216503.1	CDS	Rv1987	NC_000962.2	2231026	2231454	D	Rv1987, (MTCY39.32c), len: 142 aa. Possible chitinase (EC 3.2.1.14), similar to several e.g. P36909|CHIT_STRLI chitinase c precursor (619 aa) FASTA scores, opt: 324, E(): 1.2e-14, (39.5% identity in 129 aa overlap).; chitinase	2231026..2231454	Mycobacterium tuberculosis H37Rv	885815
NP_216504.1	CDS	Rv1988	NC_000962.2	2231680	2232219	D	Rv1988, (MTCY39.31c), len: 179 aa. Probable methyltransferase (EC 2.1.1.-), similar to ERME_SACER|P07287 rrna adenine n-6-methyltransferase (370 aa), FASTA scores: opt: 259, E(): 2e-11, (35.1% identity in 171 aa overlap); contains PS00092 N-6 Adenine-specific DNA methylases signature. Also similar to Mycobacterium tuberculosis Rv1010 ksgA 16S rRNA dimethyltransferase.; methyltransferase	2231680..2232219	Mycobacterium tuberculosis H37Rv	885632
NP_216505.1	CDS	Rv1989c	NC_000962.2	2232739	2233299	R	Rv1989c, (MTCY39.30), len: 186 aa. Hypothetical unknown protein.; hypothetical protein	complement(2232739..2233299)	Mycobacterium tuberculosis H37Rv	885810
NP_216506.1	CDS	Rv1990c	NC_000962.2	2233296	2233637	R	Rv1990c, (MTCY39.29), len: 113 aa. Probable transcriptional regulatory protein, similar to Mycobacterium tuberculosis Rv3188|AL021646|MTV014.32 (115 aa), FASTA scores: opt: 184, E(): 8.2e-07, (28.4% identity in 109 aa overlap). Contains probable helix-turn-helix motif at aa 20-44 (+4.22 SD).; transcriptional regulatory protein	complement(2233296..2233637)	Mycobacterium tuberculosis H37Rv	885422
YP_177656.1	CDS	Rv1990A	NC_000962.2	2233881	2234216	R	Rv1990A, len: 111 aa. Possible dehydrogenase (fragment) (EC 1.-.-.-), similar to N-terminal part of several dehydrogenases and hypothetical proteins, e.g. Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis (272 aa), FASTA scores: opt: 151, E(): 0.0045, (47.45% identity in 78 aa overlap), but lacks C-terminal part. Maybe a pseudogene. Also similar to U17129|RSU17129_7 putative short-chain alcohol dehydrogenase from Rhodococcus erythropolis (275 aa), FASTA scores: opt: 142, E(): 0.018, (54.15% identity in 48 aa overlap).; dehydrogenase	complement(2233881..2234216)	Mycobacterium tuberculosis H37Rv	3205104
NP_216507.1	CDS	Rv1991c	NC_000962.2	2234305	2234649	R	Rv1991c, (MTCY39.28), len: 114 aa. Conserved hypothetical protein, showing some similarity to P13976|PEMK_ECOLI pemk protein (133 aa), FASTA scores: opt: 113, E(): 0.043, (29.2% identity in 113 aa overlap); and P96622|YDCE PROTEIN from Bacillus subtilis (116 aa), FASTA scores: opt: 227, E(): 6.9e-09, (37.4% identity in 115 aa overlap). Also similar to Mycobacterium tuberculosis Rv2801c, and Rv0659c.; hypothetical protein	complement(2234305..2234649)	Mycobacterium tuberculosis H37Rv	885634
NP_216508.1	CDS	ctpG	NC_000962.2	2234991	2237306	R	Rv1992c, (MTCY39.27), len: 771 aa. Probable ctpG, metal cation-transporting P-type ATPase G (transmembrane protein) (EC 3.6.3.-), similar to others, especially cadmium-transporting ATPases (EC 3.6.3.3), e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI PROBABLE CADMIUM-TRANSPORTING ATPASE from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO PROBABLE CADMIUM-TRANSPORTING ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0969|MTCY10D7.05c|ctpV PUTATIVE CATION TRANSPORTER P-TYPE ATPASE V (770 aa); Rv1469; Rv0092; etc. Contains PS00435 Peroxidases proximal heme-ligand signature and PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB.; metal cation transporter P-type ATPase G CtpG	complement(2234991..2237306)	Mycobacterium tuberculosis H37Rv	888914
NP_216509.1	CDS	Rv1993c	NC_000962.2	2237303	2237575	R	Rv1993c, (MTCY39.26), len: 90 aa. Conserved hypothetical protein, very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap).; hypothetical protein	complement(2237303..2237575)	Mycobacterium tuberculosis H37Rv	885631
NP_216510.1	CDS	Rv1994c	NC_000962.2	2237628	2237984	R	Rv1994c, (MTCY39.25), len: 118 aa. Probable transcription regulator, similar to MERR_STRLI|P30346 probable mercury resistance operon repressor (125 aa), FASTA scores: opt: 199, E(): 3e-08, (36.3% identity in 102 aa overlap). Contains probable helix-turn-helix motif at aa 36-57 (+3.78 SD).; transcriptional regulatory protein	complement(2237628..2237984)	Mycobacterium tuberculosis H37Rv	888889
NP_216511.1	CDS	Rv1995	NC_000962.2	2238141	2238908	D	Rv1995, (MTCY39.24c), len: 255 aa. Hypothetical unknown protein.; hypothetical protein	2238141..2238908	Mycobacterium tuberculosis H37Rv	888917
NP_216512.1	CDS	Rv1996	NC_000962.2	2239004	2239957	D	Rv1996, (MTCY39.23c), len: 317 aa. Conserved hypothetical protein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv2005c|Q10851|YK05_MYCTU (295 aa), FASTA scores: opt: 775, E(): 0, (50.3% identity in 316 aa overlap); Rv2026c (294 aa) (47.9% identity in 311 aa overlap); and Rv2623, etc. Also similar to SCJ1.30c|AL109962 hypothetical protein from Streptomyces coelicolor (328 aa).; hypothetical protein	2239004..2239957	Mycobacterium tuberculosis H37Rv	888863
NP_216513.1	CDS	ctpF	NC_000962.2	2240159	2242876	D	Rv1997, (MTCY39.22c, MTCY39.21c), len: 905 aa. Probable ctpF, metal cation-transporting P-type ATPase F (transmembrane protein) (EC 3.6.3.-), highly similar to others e.g. NP_250120.1|NC_002516 probable cation-transporting P-type ATPase from Pseudomonas aeruginosa (902 aa); NP_441217.1|NC_000911 cation-transporting ATPase (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (905 aa); NP_404093.1|NC_003143 putative cation-transporting P-type ATPase from Yersinia pestis (908 aa); P37367|ATA1_SYNY3 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 2392, E(): 0, (46.5% identity in 852 aa overlap); etc. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. Was frame-shifted in original cosmid sequence.; metal cation transporter P-type ATPase A CtpF	2240159..2242876	Mycobacterium tuberculosis H37Rv	888867
NP_216514.1	CDS	Rv1998c	NC_000962.2	2242945	2243721	R	Rv1998c, (MTCY39.20), len: 258 aa. Conserved hypothetical protein, showing some similarity with other hypothetical proteins e.g. U82823|SEU82823.03 Saccharopolyspora erythraea (266 aa), FASTA results: opt: 654, E(): 0, (43.8% identity in 249 aa overlap); and AL034446|SC1A9.07 Streptomyces coelicolor (251 aa), FASTA scores: opt: 592, E(): 1.5e-31, (43.4% identity in 251 aa overlap).; hypothetical protein	complement(2242945..2243721)	Mycobacterium tuberculosis H37Rv	888853
NP_216515.1	CDS	Rv1999c	NC_000962.2	2243816	2245138	R	Rv1999c, (MTCY39.19), len: 440 aa. Probable conserved integral membrane protein, possibly transporter of cationic amino acid, similar to many transporters, especially amino acid transporters, e.g. CAC08265.1|AL392146 putative amino acid transporter from Streptomyces coelicolor (414 aa); P39277|YJEH_ECOLI hypothetical 44.8 kDa protein from Escherichia coli (418 aa), FASTA scores, opt: 343, E(): 6.6e-15, (27.2% identity in 408 aa overlap); etc. Also similar to Rv1979c from Mycobacterium tuberculosis, FASTA score: (28.2% identity in 277 aa overlap); Rv2127, Rv0346c, Rv0522, etc. SEEMS TO BELONG TO THE APC FAMILY.; integral membrane protein	complement(2243816..2245138)	Mycobacterium tuberculosis H37Rv	888881
NP_216516.1	CDS	Rv2000	NC_000962.2	2245209	2246822	D	Rv2000, (MTCY39.18c), len: 537 aa. Hypothetical unknown protein.; hypothetical protein	2245209..2246822	Mycobacterium tuberculosis H37Rv	888864
NP_216517.1	CDS	Rv2001	NC_000962.2	2246832	2247584	D	Rv2001, (MTCY39.17c), len: 250 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0466, AL021933|MTV038_10 (264 aa), FASTA scores: opt: 592, E():0, (38.0% identity in 263 aa overlap).; hypothetical protein	2246832..2247584	Mycobacterium tuberculosis H37Rv	888880
NP_216518.1	CDS	fabG3	NC_000962.2	2247660	2248442	D	Rv2002, (MTCY39.16c), len: 260 aa. Possible fabG3, 20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53), similar to e.g. 2BHD_STREX|P19992 20-beta-hydroxysteroid dehydrogenase (255 aa), FASTA scores: opt: 718, E(): 2e-38, (49.8% identity in 243 aa overlap), and many mycobacterial proteins. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; 20-beta-hydroxysteroid dehydrogenase	2247660..2248442	Mycobacterium tuberculosis H37Rv	888857
NP_216519.1	CDS	Rv2003c	NC_000962.2	2248563	2249420	R	Rv2003c, (MTCY39.14), len: 285 aa. Conserved hypothetical protein. Some similarity with Methanococcus jannaschii 67555|U67555_3 (205 aa), FASTA scores: opt: 357, E(): 3.2e-17, (33.8% identity in 204 aa overlap).; hypothetical protein	complement(2248563..2249420)	Mycobacterium tuberculosis H37Rv	888818
NP_216520.1	CDS	Rv2004c	NC_000962.2	2249478	2250974	R	Rv2004c, (MTCY39.13), len: 498 aa. Conserved hypothetical protein similar to several e.g. >pir||T36945 hypothetical protein SCJ1.12 (508 aa) - Streptomyces coelicolor >gi|5748625|emb|CAB53130.1| (AL109962). Smith-Waterman score: 7e-94, Identities = 199/468 (42%). Contains PS00017 ATP/GTP-binding site motif A.; hypothetical protein	complement(2249478..2250974)	Mycobacterium tuberculosis H37Rv	888817
NP_216521.1	CDS	Rv2005c	NC_000962.2	2250996	2251883	R	Rv2005c, (MTCY39.12), len: 295 aa. Conserved hypothetical protein, similar to MTCY39.23c, (50.3% identity in 316 aa overlap), C-terminus shows some similarity with YXIE_BACSU P42297 hypothetical 15.9 kd protein in bglh- (148 aa), FASTA scores, opt: 124, E(): 0.038, (28.5% identity in 144 aa overlap), also similar to Rv2623 (294 aa), (52.7% identity in 296 aa overlap) and other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1996, Rv2624c, Rv2028c, Rv3134c, Rv1636. Some, possibly all, of these belong to universal stress protein family.; hypothetical protein	complement(2250996..2251883)	Mycobacterium tuberculosis H37Rv	888831
YP_177855.1	CDS	otsB1	NC_000962.2	2252002	2255985	D	Rv2006, (MTCY39.11c), len: 1327 aa. Probable otsB1, trehalose-6-phosphate phosphatase (EC 3.1.3.12) (see citations below); strong similarity in central domain to OTSB_ECOLI P31678 trehalose-phosphatase (266 aa) and M. leprae TREHALOSE-PHOSPHATASE Q49734 (429 aa). Belongs to Glycosyl hydrolases family 65 (http://www.expasy.ch/cgi-bin/lists?glycosid.txt). FASTA scores, sp|Q49734|Q49734 PUTATIVE TREHALOSE-PHOSPHATASE (429 aa) opt: 1283 E(): 0; 51.7% identity in 420 aa overlap opt: 278, E(): 3.6e-11, (29.4% identity in 255 aa overlap). Note that previously known as otsB.; otsB; trehalose-6-phosphate phosphatase OtsB1	2252002..2255985	Mycobacterium tuberculosis H37Rv	888943
NP_216523.1	CDS	fdxA	NC_000962.2	2256084	2256428	R	Rv2007c, (MTCY39.10), len: 114 aa. Probable fdxA, ferredoxin, similar to e.g. FER_MYCSM P00215 ferredoxin, Mycobacterium smegmatis (106 aa), FASTA scores, opt: 448, E(): 1 .6e-21, (58.7% identity in 109 aa overlap), also similar to Rv0886|MTCY31.14, (34.2% identity in 117 aa overlap) and fdxC|Rv1177.; ferredoxin FDXA	complement(2256084..2256428)	Mycobacterium tuberculosis H37Rv	888887
NP_216524.1	CDS	Rv2008c	NC_000962.2	2256617	2257942	R	Rv2008c, (MTCY39.09), len: 441 aa. Conserved hypothetical protein. Contains PS00017 ATP/GTP-binding site motif A, PS00501 Signal peptidases I serine active site. Also contains helix-turn-helix motif at aa 258-279. Similar to several conserved hypothetical proteins e.g. NP_085874.1|14028123|dbj|BAB54715.1 hypothetical protein from Mesorhizobium loti (435 aa). Smith-Waterman score: 1e-74, Identities = 158/359 (44%); hypothetical protein	complement(2256617..2257942)	Mycobacterium tuberculosis H37Rv	888813
NP_216525.1	CDS	Rv2009	NC_000962.2	2258030	2258272	D	Rv2009, (MTCY39.08c), len: 80 aa. Conserved hypothetical protein, very similar to Rv1560|MTCY48.05c (54.4% identity in 68 aa overlap).; hypothetical protein	2258030..2258272	Mycobacterium tuberculosis H37Rv	888925
NP_216526.1	CDS	Rv2010	NC_000962.2	2258273	2258671	D	Rv2010, (MTCY39.07c), len: 132 aa. Conserved hypothetical protein, similar to Rv1561|MTCY48.04c, (38.1% identity in 126 aa overlap); hypothetical protein	2258273..2258671	Mycobacterium tuberculosis H37Rv	888933
NP_216527.1	CDS	Rv2011c	NC_000962.2	2258854	2259285	R	Rv2011c, (MTCY39.06), len: 143 aa. Conserved hypothetical protein, some similarity to putative regulatory proteins e.g. putative marR-family regulatory protein from Streptomyces coelicolor A3(2) (157 aa), emb|CAB63189.1| (AL133469) 34% identity in 110 aa overlap. Low similarity to PETP_RHOCA P31078 petp protein. Rhodobacter capsulatus (166 aa), FASTA scores, opt: 101, E(): 0 .36, (31.8% identity in 88 aa overlap); hypothetical protein	complement(2258854..2259285)	Mycobacterium tuberculosis H37Rv	888922
NP_216528.1	CDS	Rv2012	NC_000962.2	2259326	2259820	D	Rv2012, (MTCY39.05c), len: 164 aa. Conserved hypothetical protein, similar to AAK04358.1|AE006263_5 hypothetical protein from Lactococcus lactis (137 aa), (48% identity in 129 aa overlap).; hypothetical protein	2259326..2259820	Mycobacterium tuberculosis H37Rv	888927
NP_216529.2	CDS	Rv2013	NC_000962.2	2260665	2261144	D	Rv2013, (MTCY39.04c), len: 159 aa. Possible transposase: shows similarity to N-terminal part of transposase and insertion element hypothetical proteins eg sp|Q53198|Y4UE_RHISN PUTATIVE TRANSPOSASE Y4UE (359 aa) opt: 383, E(): 1.3e-18; 35.1% identity in 225 aa overlap; sp|P 14707|YM3_STRCO MINI-CIRCLE HYPOTHETICAL 45.7 kDa P (414 aa) opt: 302, E(): 4.2e-13; 33.3% identity in 207 aa overlap; and YI90_MYCPA P14322 insertion element is900 hypothetical protein (399 aa), FASTA scores, opt: 146, E(): 0.0021, (26.9% identity in 145 aa overlap). Length changed since first submission (no clear start apparent).; transposase	2260665..2261144	Mycobacterium tuberculosis H37Rv	887546
NP_216530.2	CDS	Rv2014	NC_000962.2	2261098	2261688	D	Rv2014, (MTCY39.03c), len: 196 aa. Possible transposase, similar to insertion elements e.g. sp|P14707|YM3_STRCO MINI-CIRCLE HYPOT HETICAL 45.7 kDa P (414 aa) opt: 249 z-score: 307.0 E(): 1.4e-09; 33.1% identity in 169 aa overlap; and YI90_MYCPA P14322 insertion element is900 hypothetical protein (399 a a), FASTA scores, opt: 242, z-score: 299.9, E(): 3.7e-10, (3 2.5% identity in 163 aa overlap); possibly made by frameshifting with respect to upstream ORF. Length changed since first submission.; transposase	2261098..2261688	Mycobacterium tuberculosis H37Rv	887547
NP_216531.1	CDS	Rv2015c	NC_000962.2	2261816	2263072	R	Rv2015c, (MTV018.02c), len: 418 aa. Conserved hypothetical protein. Nearly identical to Mycobacterium tuberculosis Rv1765c|MTCY28.31c, (378 aa), an ORF starting next to ISB9, and ending in IS6110. Different N-terminus chosen and C-terminus differs as that of Rv1765c has been truncated by IS6110. Does NOT show similarities with transposases. BLAST hits with non-IS part of MTU78639. FASTA scores: Z95890|MTCY28_31 (378 aa) opt: 2417, E(): 0, (97.8% identity in 364 aa overlap). TBparse score is 0.939; hypothetical protein	complement(2261816..2263072)	Mycobacterium tuberculosis H37Rv	888378
NP_216532.1	CDS	Rv2016	NC_000962.2	2263426	2264001	D	Rv2016, (MTV018.03), len: 191 aa. Hypothetical protein. TBparse score is 0.927; hypothetical protein	2263426..2264001	Mycobacterium tuberculosis H37Rv	888630
NP_216533.1	CDS	Rv2017	NC_000962.2	2263998	2265038	D	Rv2017, (MTV018.04), len: 346 aa. Possible regulatory protein; shows similarity at N-terminal end to several transcriptional regulators e.g. Z99115|BSUB0012_44 from Bacillus subtilis (108 aa), FASTA scores: opt: 154, E(): 0.0012; (35.5% identity in 62 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature in C-terminal half, may be fortuitous. TBparse score is 0.908. Contains probable helix-turn-helix motif at aa 18-39 (Score 2243, +6.83 SD).; transcriptional regulatory protein	2263998..2265038	Mycobacterium tuberculosis H37Rv	888435
NP_216534.1	CDS	Rv2018	NC_000962.2	2265280	2265999	D	Rv2018, (MTV018.05), len: 239 aa. Conserved hypothetical protein, similar to Rv2308|MTCY339.01c (238 aa). FASTA scores: Z77163|MTCY339_1 Mycobacterium tuberculosis cosmid (238 aa) opt: 142, E(): 0.029; (24.8% identity in 250 aa overlap). Contains probable helix-turn-helix motif at aa 215-236 (Score 1175, +3.19 SD). TBparse score is 0.929.; hypothetical protein	2265280..2265999	Mycobacterium tuberculosis H37Rv	887560
NP_216535.1	CDS	Rv2019	NC_000962.2	2265989	2266405	D	Rv2019, (MTV018.06), len: 138 aa. Hypothetical protein.; hypothetical protein	2265989..2266405	Mycobacterium tuberculosis H37Rv	887665
NP_216536.1	CDS	Rv2020c	NC_000962.2	2266421	2266720	R	Rv2020c, (MTV018.07c), len: 99 aa. Conserved hypothetical protein, nearly identical to C-terminal part of hypothetical protein RvD1-Rv2024c' from Mycobacterium bovis BCG (1606 aa) emb|CAB44655.1| (Y18605). Corresponds to deletion region RvD1 so probably truncated protein. TBparse score is 0.891; hypothetical protein	complement(2266421..2266720)	Mycobacterium tuberculosis H37Rv	887656
NP_216537.1	CDS	Rv2021c	NC_000962.2	2266805	2267110	R	Rv2021c, (MTV018.08c), len: 101 aa. Possible regulatory protein, similar to Rv3183|MTV014.27|AL021646 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN from M. tuberculosis (109 aa), FASTA scores: opt: 214, E(): 1.2e-09, (43.0% identity in 107 aa overlap). TBparse score is 0.913. Contains probable helix-turn-helix at aa 45-66 (Score 1472, +4.20 SD).; transcriptional regulatory protein	complement(2266805..2267110)	Mycobacterium tuberculosis H37Rv	888092
NP_216538.1	CDS	Rv2022c	NC_000962.2	2267119	2267724	R	Rv2022c, (MTV018.09c), len: 201 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv3182, MTV014.26 (EMBL:AL 021646). FASTA scores; TR:E1248773 (114 aa) opt: 335, E(): 3e-22, 53.8% identity in 106 aa overlap and to hypothetical proteins from Yersinia pestis (115 aa) e.g. emb|CAB53172.1| (AL109969), 41% identity in 108 aa overlap. TBparse score is 0.912; hypothetical protein	complement(2267119..2267724)	Mycobacterium tuberculosis H37Rv	888129
NP_216539.1	CDS	Rv2023c	NC_000962.2	2267749	2268108	R	Rv2023c, (MTV018.10c), len: 119 aa. Hypothetical protein, alternative upstream start possible. TBparse score is 0.913; hypothetical protein	complement(2267749..2268108)	Mycobacterium tuberculosis H37Rv	887444
NP_216540.1	CDS	Rv2024c	NC_000962.2	2268693	2270240	R	Rv2024c, (MTV018.11c), len: 515 aa. Conserved hypothetical protein. Identical to N-terminal part of much larger hypothetical protein, RvD1-Rv2024c' (1606 aa), from Mycobacterium bovis BCG: CAB44655.1|Y18605|13881753|AAK46361.1|AE007059 so probably truncated. Part of RvD1 chromosomal deletion region. Also similar to hypothetical protein from Helicobacter pylori. FASTA scores: AE0005|HPAE000580_2 Helicobacter pylori (607 aa) opt: 64, E(): 0, (36.2% identity in 464 aa overlap). TBparse score is 0.879; hypothetical protein	complement(2268693..2270240)	Mycobacterium tuberculosis H37Rv	888351
NP_216541.1	CDS	Rv2025c	NC_000962.2	2270750	2271748	R	Rv2025c, (MTV018.12c), len: 332 aa. Possible conserved transmembrane protein, CDF family possibly involved in transport of metal ions, similar to several hypothetical bacterial proteins e. g. Methanobacterium thermoautotrophicum AE000941_1 (298 aa; described as cation efflux system protein) and Archaeoglob us fulgidus AE001111_5 (384 aa). FASTA scores: AE000941_1 M ethanobacterium thermoautotrophicum (298 aa) opt: 452 E(): 3.3e-24; 30.8% identity in 266 aa overlap and AE001111_5 Archaeoglobus fulgidus section 16 (384 aa) opt: 371 E(): 1.7e-18; 27.7% identity in 267 aa overlap. TBparse score is 0.897; hypothetical protein	complement(2270750..2271748)	Mycobacterium tuberculosis H37Rv	888782
NP_216542.1	CDS	Rv2026c	NC_000962.2	2271863	2272747	R	Rv2026c, (MTV018.13c), len: 294 aa. Conserved hypothetical protein, very similar to Mycobacterium tuberculosis hypothetical proteins Rv2005c, Rv2623, Rv1996, Rv2624c, Rv2028c, Rv3134c, Rv1636. Some, possibly all, of these belong to universal stress protein family. TBparse score is 0.946; hypothetical protein	complement(2271863..2272747)	Mycobacterium tuberculosis H37Rv	887460
NP_216543.1	CDS	Rv2027c	NC_000962.2	2272787	2274508	R	Rv2027c, (MTV018.14c), len: 573 aa. Probable histidine kinase response regulator, highly similar to others e.g. NP_628132.1|NC_003888 putative two component sensor from Streptomyces coelicolor (560 aa); NP_626695.1|NC_003888 putative two-component sensor histidine kinase from Streptomyces coelicolor (475 aa); etc. Highly similar to Mycobacterium tuberculosis protein Rv3132c, MTCY03A2.2 6. FASTA scores: Z83867|MTCY3A2_26 (578 aa) opt: 2330, E(): 0; 62.5% identity in 560 aa overlap. TBparse score is 0.903; histidine kinase response regulator	complement(2272787..2274508)	Mycobacterium tuberculosis H37Rv	888471
NP_216544.1	CDS	Rv2028c	NC_000962.2	2274569	2275408	R	Rv2028c, (MTV018.15c), len: 279 aa. Conserved hypothetical protein, highly similar to Mycobacterium tuberculosis proteins Rv2005c, Rv2623, Rv1996, Rv2624c, Rv3134c, Rv1636. Some, possibly all, of these belong to universal stress protein family. Rv2624c|MTCY01A10.08 (272 aa) and Rv3134c|MTCY03A2.24 (268 aa). FASTA scores: Z95387|MTCY1A10_8 (272 aa) opt: 563, E(): 2.5e-31, (36.8% identity in 266 aa overlap) and Z83867|MTCY3A2_24 (268 aa) opt: 562, E(): 2.9e-31, (40.7% identity in 273 aa overlap). TBparse score is 0.904; hypothetical protein	complement(2274569..2275408)	Mycobacterium tuberculosis H37Rv	888494
NP_216545.1	CDS	pfkB	NC_000962.2	2275405	2276424	R	Rv2029c, (MTV018.16c), len: 339 aa. Probable pfkB, phosphofructokinase (EC 2.7.1.-), similar to others eg P06999|K6P2_ECOLI 6-PHOSPHOFRUCTOKINASE I SOZYME 2 from E. coli (309 aa), FASTA scores: opt: 705, E(): 0; (41.4% identity in 304 aa overlap); and LACC_STRMU phosphotagatosekinase (310 aa); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1. TBparse score is 0.927.; phosphofructokinase PfkB (phosphohexokinase)	complement(2275405..2276424)	Mycobacterium tuberculosis H37Rv	887491
NP_216546.1	CDS	Rv2030c	NC_000962.2	2276441	2278486	R	Rv2030c, (MTV018.17c), len: 681 aa. Conserved hypothetical protein that corresponds to products of two adjacent ORF's described previously MSGTUBDWN_4 (390 aa) and MSGTUBDWN_1 (385 aa). Also similar to C-terminal two-thirds of Mycobacterium tuberculosis protein Rv2143 (MTCY270.25c; 352 aa) and to Rv0571c (443 aa) and M. leprae protein U650s MLU15184_16 (258 aa). FASTA scores: M93129|MSGTUBDWN_4 (390 aa) opt: 2530 E(): 0; 97.7% identity in 385 aa overlap and M93129|MSGTUBDWN_1 (385 aa) opt: 1983 E(): 0; 99.0% identity in 309 aa overlap. Z95388| MTCY270_25 (352 aa) opt: 882 E(): 0; 61.1 % identity in 226 aa overlap. U15184|MLU15184_16 (258 aa) opt: 549 E(): 9.8e-29; 43.8% identity in 219 aa overlap. TBparse score is 0.907; hypothetical protein	complement(2276441..2278486)	Mycobacterium tuberculosis H37Rv	887536
NP_216547.1	CDS	hspX	NC_000962.2	2278498	2278932	R	Rv2031c, (MTV018.18c), len: 144 aa. hspX, heat shock protein localized in the inner membrane (see citations below). Identical to P30223|14KD_MYCTU 14 KD ANTIGEN (16 kDa ANTIGEN) (HSP 16.3) of Mycobacterium tuberculosis (143 aa), FASTA scores: opt: 933, E(): 0, (100.0% identity in 143 aa overlap). BELONGS TO THE SMALL HEAT SHOCK PROTEIN (HSP20) FAMILY. Also known as alpha-crystallin and gene as acr (see some citations below). TBparse score is 0.897.; acr; heat shock protein hspX	complement(2278498..2278932)	Mycobacterium tuberculosis H37Rv	887579
NP_216548.1	CDS	acg	NC_000962.2	2279129	2280124	D	Rv2032, (MTV018.19), len: 331 aa. acg (for acr-coregulated gene), conserved hypothetical protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al., 2002), similar to hypothetical mycobacterial proteins Rv3127|MTCY164.37 (344 aa) and Rv3131|MTCY03A2.27c (332 aa). FASTA scores: Z95150|MTCY164_38 Mycobacterium tuberculosis cosmid (344 aa) opt: 1208, E(): 0, (56.4% identity in 321 aa overlap); Z83867| MTCY3A2_27 Mycobacterium tuberculosis cosmid (332 aa) opt: 568, E(): 8.6e-30, (36.8% identity in 321 aa overlap). Similar to proteins SCJ1.11 (330 aa; AL109962) and SCJ12.27c (335 aa; AL109989) in Streptomyces coelicolor. TBparse score is 0.931.; hypothetical protein	2279129..2280124	Mycobacterium tuberculosis H37Rv	887582
NP_216549.1	CDS	Rv2033c	NC_000962.2	2280240	2281082	R	Rv2033c, (MTV018.20), len: 280 aa. Conserved hypothetical protein, similar to hypothetical protein SCC77.24 (274 aa) from Streptomyces coelicolor A3(2) CAB66235.1|AL13650) (50% identity in 261 aa overlap). TBparse score is 0.897; hypothetical protein	complement(2280240..2281082)	Mycobacterium tuberculosis H37Rv	887972
NP_216550.1	CDS	Rv2034	NC_000962.2	2281294	2281617	D	Rv2034, (MTV018.21), len: 107 aa. Probable repressor protein similar to several belonging to the ARSR FAMILY e.g. Q53040 (112 aa). FASTA scores: sptr|Q53040|Q53040 NITRILE HYDRATASE REGULATAR 2 (112 aa) opt: 167, E( ): 6.7e-06; 44.7% identity in 76 aa overlap. TBparse score is 0.905. Contains probable helix-turn-helix at aa 32-53 (S core 1350, +3.78 SD); ArsR-type repressor protein	2281294..2281617	Mycobacterium tuberculosis H37Rv	887859
NP_216551.1	CDS	Rv2035	NC_000962.2	2281614	2282102	D	Rv2035, (MTV018.22), len: 162 aa. Conserved hypothetical protein, similar to conserved hypothetical protein (156 aa) from Sinorhizobium meliloti CAC46569.1|AL591789 (34% identity in 146 aa overlap). TBparse score is 0.925; hypothetical protein	2281614..2282102	Mycobacterium tuberculosis H37Rv	887445
NP_216552.1	CDS	Rv2036	NC_000962.2	2282099	2282740	D	Rv2036, (MTV018.23), len: 213 aa. Conserved hypothetical protein; slight similarity to Streptomyces lincolnensis protein involved in lincomycin production Q54375 (238 aa). FASTA scores: sptr|Q54375|Q54375 (78-11) LINCOMYCIN PRODUCTION GENES (238 aa) opt: 119, E(): 0.97; 31.3% identity in 99 aa overlap. TBparse score is 0.934; hypothetical protein	2282099..2282740	Mycobacterium tuberculosis H37Rv	887433
NP_216553.1	CDS	Rv2037c	NC_000962.2	2282747	2283721	R	Rv2037c, (MTV018.24c), len: 324 aa. Possible conserved transmembrane protein, similar to hypothetical proteins from Mycobacterium leprae MLCB2052.31 (329 aa) and Bacillus subtilis P54513|YQHO_BACSU (291 aa). FASTA scores: Z98604|MLCB2052_1 6 Mycobacterium leprae cosmid B205 (329 aa) opt: 1764, E(): 0; 80.5% identity in 323 aa overlap and sp|P54513|YQHO_BACSU HYPOTHETICAL 32.9 KD PROTEIN IN G (291 aa ) opt: 328, E(): 8.8e-14; 36.6% identity in 306 aa overlap. TBparse score is 0.919; transmembrane protein	complement(2282747..2283721)	Mycobacterium tuberculosis H37Rv	888021
NP_216554.1	CDS	Rv2038c	NC_000962.2	2283723	2284796	R	Rv2038c, (MTV018.25c), len: 357 aa. Probable sugar-transport ATP-binding protein ABC transporter (see citation below), equivalent to MLCB2052.30|Z98604|MLCB2052_15 from Mycobacterium leprae (356 aa), FASTA scores: opt: 1866, E(): 0, (79.7% identity in 355 aa overlap). Also similar to multiple sugar import proteins e.g. Y08921|SRMSIK_1 msiK protein from Streptomyces reticuli (377 aa), FASTA scores: opt: 1336, E(): 0, (62.6% identity in 377 aa overlap); etc. Also similar to several proteins from Mycobacterium tuberculosis e.g. Rv2832c, Rv1238, Rv2397c, Rv3758c. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.923.; sugar-transport ATP-binding protein ABC transporter	complement(2283723..2284796)	Mycobacterium tuberculosis H37Rv	887998
NP_216555.1	CDS	Rv2039c	NC_000962.2	2284799	2285641	R	Rv2039c, (MTV018.26c), len: 280 aa. Probable sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to MLCB2052.29|Z98604|MLCB2052_14 from Mycobacterium leprae (283 aa), FASTA scores: opt: 1593, E(): 0, (79.2% identity in 283 aa overlap). Also similar to maltose and lactose transport proteins e.g. X66092|CPMALGHOM_1 from C. perfringens (275 aa), FASTA scores: opt: 695, E(): 0, (41.2% identity in 228 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. Also contains possible helix-turn-helix motif at aa 171-192, although this is probably fortuitous. TBparse score is 0.912.; sugar-transport integral membrane protein ABC transporter	complement(2284799..2285641)	Mycobacterium tuberculosis H37Rv	887729
NP_216556.1	CDS	Rv2040c	NC_000962.2	2285628	2286530	R	Rv2040c, (MTV018.27c), len: 300 aa. Probable sugar-transport integral membrane protein ABC transporter (see citation below), equivalent to MLCB2052.28|Z98604|MLCB2052_13 from Mycobacterium leprae (319 aa), FASTA scores: opt: 1606, E(): 0, (81.6% identity in 293 aa overlap). Also similar to many diverse sugar transport proteins. TBparse score is 0.934.; sugar-transport integral membrane protein ABC transporter	complement(2285628..2286530)	Mycobacterium tuberculosis H37Rv	887893
NP_216557.1	CDS	Rv2041c	NC_000962.2	2286527	2287846	R	Rv2041c, (MTV018.28c), len: 439 aa. Probable sugar-binding lipoprotein component of sugar transport system, equivalent to Z98604|MLCB2052_1|MLCB2052.27 from Mycobacterium leprae (445 aa), FASTA scores: opt: 2324, E(): 0, (77.4% identity in 446 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.927.; sugar-binding lipoprotein	complement(2286527..2287846)	Mycobacterium tuberculosis H37Rv	887474
NP_216558.1	CDS	Rv2042c	NC_000962.2	2287884	2288681	R	Rv2042c, (MTV018.29c), len: 265 aa. Conserved hypothetical protein,similar in N-terminal part to hypothetical proteins MLCB2052.24 (95 aa) and Rv0760c|MTCY369.05 (139 aa). FASTA scores: Z98604|MLCB2052_9 Mycobacterium leprae cosmid B2052 (95 aa) opt: 269, E(): 2.9e-12, (55.4% identity in 92 aa overlap) and Z80226|MTCY369_5 Mycobacterium tuberculosis cosmid (139 aa) opt: 150, E(): 0.001, (28.7% identity in 136 aa overlap). TBparse score is 0.909; hypothetical protein	complement(2287884..2288681)	Mycobacterium tuberculosis H37Rv	887497
NP_216559.1	CDS	pncA	NC_000962.2	2288681	2289241	R	Rv2043c, (MTV018.30c), len: 186 aa. pncA, pyrazinamidase/nicotinamidase (EC 3.5.1.-) (see citations below). Identical to PYRAZINAMIDASE/NICOTINAMIDASE involved in susceptibility or resistance to antituberculous drug pyrazinamide. FASTA scores: sptr|Q50575|Q50575 PYRAZINAMIDASE/NICOTINAMIDASE. (186 aa) opt: 1236, E(): 0; 100.0% identity in 186 aa overlap. TBparse score is 0.892.; pyrazinamidase/nicotinamidas PNCA (PZase)	complement(2288681..2289241)	Mycobacterium tuberculosis H37Rv	888260
NP_216560.1	CDS	Rv2044c	NC_000962.2	2289282	2289599	R	Rv2044c, (MTV018.31c), len: 105 aa. Conserved hypothetical protein, similar to conserved hypothetical protein PA3386 (121 aa) from Pseudomonas aeruginosa |E83221 conserved hypothetical protein PA3386 [imported] - Pseudomonas aeruginosa (strain PAO1) 9949522|gb|AAG06774.1|AE004760_2 (AE004760). (46% identity in 92 aa overlap). TBparse score is 0.914; hypothetical protein	complement(2289282..2289599)	Mycobacterium tuberculosis H37Rv	888243
NP_216561.1	CDS	lipT	NC_000962.2	2289685	2291220	R	Rv2045c, (MTV018.32c), len: 511 aa. Probable lipT, carboxylesterase similar to many e.g. O08472 (489 aa) and P37967|PNBA_ BACSU (489 aa). PARA-NITROBENZYL ESTERASE (EC 3.1.1.-). Contains PS00941 Carboxylesterases type-B signature 2. Contains PS00122 Carboxylesterases type-B serine active site. FASTA scores: sptr|O08472|O08472 INTRACELLULAR ESTERASE B (489 aa) opt: 849, E(): 0, (36.2% identity in 489 aa overlap) and sp|P37967|PNBA_BACSU PARA-NITROBENZYL ESTERASE (489 aa) opt: 838, E(): 0, (36.0% identity in 489 aa overlap). TBparse score is 0 .918; carboxylesterase LipT	complement(2289685..2291220)	Mycobacterium tuberculosis H37Rv	888358
NP_216562.1	CDS	lppI	NC_000962.2	2291269	2291925	D	Rv2046, (MTV018.33), len: 218 aa. Probable lppI, lipoprotein contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.898; lipoprotein lppI	2291269..2291925	Mycobacterium tuberculosis H37Rv	888308
NP_216563.1	CDS	Rv2047c	NC_000962.2	2291962	2294526	R	Rv2047c, (MTV018.34c), len: 854 aa. Conserved hypothetical protein, similar to hypothetical protein from Mycobacterium tuberculosis Rv1868|MTCY359.05c (699 aa) and three possible pseudogene fragments from Mycobacterium leprae MLCB2052.16 (251 aa), MLCB2052.17 (120 aa), MLCB2052.18 (257 aa). FASTA scores: gp|Z98604|MLCB2052_7 (257 aa) opt: 1248, E(): 0, (78.6% identity in 248 aa overlap); and Z98604|MLCB2052_5 (251 aa) opt: 674, E(): 0, (50.0% identity in 250 aa overlap); and Z98604|MLCB2052_6 (120 aa) opt: 608 E() : 3.6e-30, (84.0% identity in 106 aa overlap); and Rv1868 Z83859|MTCY359_5 (699 aa) opt: 521 E(): 3e-24; (33.0% identity in 730 aa overlap). TBparse score is 0.917; hypothetical protein	complement(2291962..2294526)	Mycobacterium tuberculosis H37Rv	888529
NP_216564.1	CDS	pks12	NC_000962.2	2294531	2306986	R	Rv2048c, (MTV018.35c), len: 4151 aa. Probable pks12, polyketide synthase similar to many polyketide synthases e.g. the second and third modules of polyketide synthase from S. erythraea (3567 aa), many other Streptomyces enzymes and putative Mycobacterium tuberculosis polyketide synthases, e.g. Z85982|MTCY06H11.26 (2126 aa), FASTA scores: opt: 6668, E(): 0 (61.2% identity in 2058 aa overlap); and Q03132|ERY2_SACER ERYTHRONOLIDE SYNTHASE, MODULES 3 from S. erythraea (3567 aa), FASTA scores: opt: 5309, E(): 0, (40.5% identity in 4141 aa overlap). Contains 2x PS00012 Phosphopantetheine attachment site, 2x PS00606 Beta-ketoacyl synthases active site, and PS00343 Gram-positive cocci surface proteins 'anchor ing' hexapeptide. TB parse score is 0.902.; polyketide synthase pks12	complement(2294531..2306986)	Mycobacterium tuberculosis H37Rv	888350
NP_216565.1	CDS	Rv2049c	NC_000962.2	2307293	2307517	R	Rv2049c, (MTV018.36c), len: 74 aa. Hypothetical protein. TBparse score is 0.867; hypothetical protein	complement(2307293..2307517)	Mycobacterium tuberculosis H37Rv	888593
NP_216566.1	CDS	Rv2050	NC_000962.2	2307821	2308156	D	Rv2050, (MTV018.37), len: 111 aa. Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium leprae, MLCB2052.03c (113 aa), and Streptomyces coelicolor A3(2), SC6D7.18c (124 aa). FASTA scores: Z98604|MLCB2052_3 Mycobacterium leprae cosmid B2052 (113 aa) opt: 737, E(): 0, (97.3% identity in 111 aa overlap) and (55% identity in 85 aa overlap) with emb|CAB61670.1|AL133213 hypothetical protein SC6D7.18c. TBparse score is 0.884; hypothetical protein	2307821..2308156	Mycobacterium tuberculosis H37Rv	888598
NP_216567.1	CDS	ppm1	NC_000962.2	2308131	2310755	R	Rv2051c, (MTV018.38c), len: 874 aa. ppm1, Polyprenol-monophosphomannose synthase. Transfers mannose from GDP-Mannose to all endogenous polyprenol-phosphates in Mycobacterium tuberculosis, proven experimentally (A. Baulard, Institut Pasteur de Lille: see citation below). Very similar to polyprenol-phosphate-mannose synthases from Mycobacterium smegmatis (594 aa). Two-domain protein similar to products of two adjacent ORFs in Mycobacterium leprae MLCB2052.01 (644 aa), probable membrane protein and MLCB2052.02 (277 aa). First domain (aa 1 - 590) corresponds to membrane protein with similarity to P23930|LNT_ECOLI apolipoprotein n-acyltransferase (512 aa) while second domain (aa 591 - 874) is similar to Schizosaccharomyces pombe dolichol monophosphate mannose synthase (236 aa) and to Mycobacterium tuberculosis Rv0539. FASTA scores: Z 98604|MLCB2052_1 (644 aa) opt: 2725 E(): 0 ; 67.7% identity in 601 aa overlap; and Z98604|MLCB2052_2 (277 aa) opt: 1449 E(): 0; 78.9% identity in 275 aa overlap; and gp|AF0078|AF007873_1 Schizosaccharomyces pombe dolichocholmonophosphate mannose synthase (236 aa) opt: 456 E(): 7.8e-19; 34.5% identity in 223 aa overlap and sp|P23930|LNT_ECOLI APOLIPOPROTEIN N-ACYLTRANSFERASE (512 aa) opt: 330 E(): 1.9e-11; 26.9% identity in 539 aa overlap; and polyprenol-phosphate-mannose synthases from Mycobacterium smegmatis (594 aa). CAC15462.1|AJ294477 putative polyprenol-phosphate-mannose synthase 2 (Ppm2): (55% identity in 533 aa overlap).; polyprenol-monophosphomannose synthase Ppm1	complement(2308131..2310755)	Mycobacterium tuberculosis H37Rv	887402
NP_216568.1	CDS	Rv2052c	NC_000962.2	2310913	2312517	R	Rv2052c, (MTV018.39c), len: 534 aa. Conserved hypothetical protein, very similar to hypothetical protein SC6D7.15 (536 aa) from Streptomyces coelicolor A3(2). Smith-Waterman scores >emb|CAB61667.1| (AL133213) hypothetical protein SC6D7.15 [Streptomyces coelicolor A3(2)] Expect = e-113 Identities = 247/533 (46%); hypothetical protein	complement(2310913..2312517)	Mycobacterium tuberculosis H37Rv	888608
NP_216569.1	CDS	fxsA	NC_000962.2	2312522	2313049	R	F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA	complement(2312522..2313049)	Mycobacterium tuberculosis H37Rv	888768
NP_216570.1	CDS	Rv2054	NC_000962.2	2313125	2313838	D	Rv2054, (MTCY63A.06c), len: 237 aa. Conserved hypothetical protein, some similarity to various carboxymethylenebutenolidases e.g. sp|O67988|CLCD_RHOOP CARBOXYMETHYLENEBUTENOLIDASE (DIENELACTONE HYDROLASE) (DLH) >gi|2935034|gb|AAC38252.1| (AF003948) dienelactone hydrolase [Rhodococcus opacus] Smith-Waterman scores: Length = 252, Expect = 4e-08 Identities = 62/217 (28%). Also similar to Rv2765. TBparse score is 0.921; hypothetical protein	2313125..2313838	Mycobacterium tuberculosis H37Rv	888722
NP_216571.1	CDS	rpsR	NC_000962.2	2314087	2314353	R	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18	complement(2314087..2314353)	Mycobacterium tuberculosis H37Rv	887817
NP_216572.1	CDS	rpsN	NC_000962.2	2314354	2314659	R	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14	complement(2314354..2314659)	Mycobacterium tuberculosis H37Rv	887819
YP_177856.1	CDS	rpmG	NC_000962.2	2314661	2314825	R	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33	complement(2314661..2314825)	Mycobacterium tuberculosis H37Rv	887807
NP_216574.1	CDS	rpmB	NC_000962.2	2314825	2315061	R	required for 70S ribosome assembly; 50S ribosomal protein L28	complement(2314825..2315061)	Mycobacterium tuberculosis H37Rv	887801
NP_216575.1	CDS	Rv2059	NC_000962.2	2315174	2316709	D	Rv2059, (MTCY63A.01c), len: 511 aa. Conserved hypothetical protein. Some similarity to EWLA protein gp|U52850|ERU52850_1 Erysipelothrix rhusiopathiae 36 k (304 aa), FASTA score, opt: 287 E(): 6.9e-09; 27.2% identity in 228 aa overlap. There appears to be a frameshift in this ORF around position 3315980 that causes an overlap with next ORF. C-terminal end of protein may be wrong. No error can be found to account for this.; hypothetical protein	2315174..2316709	Mycobacterium tuberculosis H37Rv	888402
NP_216576.1	CDS	Rv2060	NC_000962.2	2316279	2316680	D	Rv2060, (MTV019.01), len: 133 aa. Possible conserved integral membrane protein smaller than but similar to several hypothetical bacterial proteins e.g. >emb|CAC29843.1| (AL583918) putative ABC-transporter transmembrane protein [Mycobacterium leprae] Length = 286 and P44691|YEBI_HAEIN (261 aa). FASTA scores: P44691|YEBI_HAEIN HYPOTHETICAL PROTEIN HI0407 (261 aa) opt: 218, E(): 4.2e-08; 31.1% identity in 122 aa overlap. Maybe frameshift upstream at position 3315980 but no error can be found to account for this. TBparse score is 0.871; integral membrane protein	2316279..2316680	Mycobacterium tuberculosis H37Rv	888388
NP_216577.1	CDS	Rv2061c	NC_000962.2	2316681	2317085	R	Rv2061c, (MTV019.02c), len: 134 aa. Conserved hypothetical protein. Similar to conserved hypothetical proteins from Mycobacterium leprae (128 aa) and Streptomyces coelicolor (153 aa). Smith-Waterman scores: >emb|CAC30396.1| (AL583922) [Mycobacterium leprae], Expect = 7e-47, Identities = 92/131 (70%); >emb|CAC14932.1| (AL449216) [Streptomyces coelicolor], Expect = 6e-19 Identities = 48/124 (38%). TBparse score is 0.862; hypothetical protein	complement(2316681..2317085)	Mycobacterium tuberculosis H37Rv	888246
NP_216578.1	CDS	cobN	NC_000962.2	2317169	2320753	R	with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN	complement(2317169..2320753)	Mycobacterium tuberculosis H37Rv	888252
YP_177657.1	CDS	Rv2063	NC_000962.2	2320831	2321064	D	Rv2063, len: 77 aa. Conserved hypothetical protein, showing some similarity to other conserved hypothetical proteins e.g. AL109974_2|SCF34.02c hypothetical protein from Streptomyces coelicolor (133 aa), FASTA scores: opt: 102, E(): 1.7, (34.35% identity in 67 aa overlap); and AE005182_1 from Escherichia coli strain O157:H7 (77 aa), FASTA scores: opt: 95, E(): 3.3, (34.85% identity in 66 aa overlap). This ORF replaces previous Rv2063c on other strand.; hypothetical protein	2320831..2321064	Mycobacterium tuberculosis H37Rv	3205116
NP_216580.1	CDS	cobG	NC_000962.2	2321451	2322542	D	Rv2064, (MTCY49.03), len: 363 aa. Possible cobG, cobalamin biosynthesis protein. Some similarity to COBG_PSEDE P21637 cobg protein. pseudomonas (459 aa) FASTA scores, opt: 240, E(): 1.3e-08, (27.5% identity in 407 aa overlap); contains PS01156 TonB-dependent receptor proteins signature 2; cobalamin biosynthesis protein CobG	2321451..2322542	Mycobacterium tuberculosis H37Rv	888140
NP_216581.1	CDS	cobH	NC_000962.2	2322552	2323178	D	catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase	2322552..2323178	Mycobacterium tuberculosis H37Rv	888464
NP_216582.1	CDS	cobI	NC_000962.2	2323175	2324701	D	Rv2066, (MTCY49.05), len: 508 aa. Probable CobI-CobJ fusion protein, S-adenosyl-L-methionine-precorrin-2 methyl transferase and precorrin-3 methylase (EC 2.1.1.-). Similar in N-terminal half (aa 1-240) to COBI_PSEDE|P21639, S-adenosyl-L-methionine-precorrin-2 methyl transferase (244 aa), FASTA scores: opt: 759, E(): 4.4e-34, (49.2% identity in 238 aa overlap); and in C-terminal half (aa 240-508) to P21640|COBJ_PSEDE PRECORRIN-3 METHYLASE (EC 2.1.1.-) (254 aa), FASTA scores: opt: 695, E(): 0, (45.3% identity in 258 aa overlap).; bifunctional S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase Cob I/J	2323175..2324701	Mycobacterium tuberculosis H37Rv	888483
NP_216583.1	CDS	Rv2067c	NC_000962.2	2324647	2325870	R	Rv2067c, (MTCY49.06c), len: 407 aa. Conserved hypothetical protein, some similarity to YAT1_SYNP6 P08442 atp synthase subunits region ORF 1. (417 aa), FASTA scores, opt: 373, E(): 4.9e-18, (27.7% identity in 358 aa overlap); hypothetical protein	complement(2324647..2325870)	Mycobacterium tuberculosis H37Rv	888752
NP_216584.1	CDS	blaC	NC_000962.2	2325886	2326809	R	Rv2068c, (MTCY49.07c), len: 307 aa. blaC, class A beta-lactamase (EC 3.5.2.6) (see citation below), similar to e.g. BLAC_NOCLA Q06316 beta-lactamase precursor (302 aa), FASTA scores, opt: 860, E(): 0, (50.2% identity in 283 aa overlap); eyc. Contains PS00013 Prokaryotic lipid attachment site near N-terminus, and PS00146 Beta-lactamase class-A active site. BELONGS TO THE CLASS-C BETA-LACTAMASE FAMILY.; class A BETA-lactamase BLAC	complement(2325886..2326809)	Mycobacterium tuberculosis H37Rv	888742
NP_216585.1	CDS	sigC	NC_000962.2	2326944	2327501	D	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC	2326944..2327501	Mycobacterium tuberculosis H37Rv	888723
NP_216586.1	CDS	cobK	NC_000962.2	2327491	2328225	R	CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase	complement(2327491..2328225)	Mycobacterium tuberculosis H37Rv	887566
NP_216587.1	CDS	cobM	NC_000962.2	2328222	2328977	R	Rv2071c, (MTCY49.10c), len: 251 aa. Probable cobM, precorrin-3 methylase (EC 2.1.1.133), similar to e.g. L21196|g347169|RERCOBLMK2 RERCOBLMK from Rhodococococcus sp. NI86/21 (249 aa), FASTA scores: opt: 992, E(): 0, (62.4% identity in 245 aa overlap) and to COBM_ PSEDE|P21922 precorrin-3 methylase (253 aa), FASTA scores: opt: 863, E(): 0, (54.6% identity in 249 aa overlap). Contains PS00839 Uroporphyrin-III C-methyltransferase signature 1, and PS00840 Uroporphyrin-III C-methyltransferase signature 2.; precorrin-4 C11-methyltransferase CobM	complement(2328222..2328977)	Mycobacterium tuberculosis H37Rv	888521
NP_216588.1	CDS	cobL	NC_000962.2	2328974	2330146	R	Rv2072c, (MTCY49.11c), len: 390 aa. Probable cobL, methyl transferase (EC 2.1.1.132), similar to L21196|g347169|RERCOBLMK1 from Rhodocococcus sp. NI86/21 (447 aa), FASTA scores: opt: 892; E(): 0; (50.1% identity in 369 aa overlap), and to COBL_PSEDE|P21921 precorrin-6y methylase (413 aa), FASTA scores: opt: 830, E(): 0, (40.6% identity in 404 aa overlap).; precorrin-6y methyltransferase CobL	complement(2328974..2330146)	Mycobacterium tuberculosis H37Rv	888321
NP_216589.1	CDS	Rv2073c	NC_000962.2	2330214	2330963	R	Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase (EC 1.-.-.-), belonging to shortchain dehydrogenase reductase (SDR) family, similar to e.g. YMP3_STRCO P43168 hypothetical 25.8 kDa protein in mpra 5' region (251 aa) FASTA scores: opt: 386, E(): 1.1e-18, (44.1% identity in 170 aa overlap). Similar to several M. tuberculosis hypothetical proteins, e.g. Rv3791, Rv1544,Rv0945, Rv0765c. etc.; shortchain dehydrogenase	complement(2330214..2330963)	Mycobacterium tuberculosis H37Rv	887267
NP_216590.1	CDS	Rv2074	NC_000962.2	2330993	2331406	D	Rv2074, (MTCY49.13), len: 137 aa. Conserved hypothetical protein, similar to SCF43A.28 hypothetical protein from Streptomyces coelicolor (141 aa). Smith-Waterman scores: 5459242|CAB48915.1|AL096837 hypothetical protein from Streptomyces coelicolor A3(2) Expect = 1e-21, Identities = 56/106 (52%).; hypothetical protein	2330993..2331406	Mycobacterium tuberculosis H37Rv	888523
NP_216591.1	CDS	Rv2075c	NC_000962.2	2331416	2332879	R	Rv2075c, (MTCY49.14c), len: 487 aa. Possibly exported or envelope protein; has potential signal peptide at N-terminus and hydrophobic stretch around residue 430.; hypothetical protein	complement(2331416..2332879)	Mycobacterium tuberculosis H37Rv	888771
NP_216592.1	CDS	Rv2076c	NC_000962.2	2333037	2333288	R	Rv2076c, (MTCY49.15c), len: 83 aa. Unknown, questionable ORF.; hypothetical protein	complement(2333037..2333288)	Mycobacterium tuberculosis H37Rv	887296
NP_216593.1	CDS	Rv2077c	NC_000962.2	2333323	2334294	R	Rv2077c, (MTCY49.16c), len: 323 aa. Possible conserved transmembrane protein. Part of Mycobacterium tuberculosis protein family with Rv2542, Rv2079, Rv2797c, Rv0963c, Rv1949c. Hydrophobic stretches at C-terminus.; transmembrane protein	complement(2333323..2334294)	Mycobacterium tuberculosis H37Rv	887785
YP_177658.1	CDS	Rv2077A	NC_000962.2	2334295	2334594	R	Rv2077A, len: 99 aa. Conserved hypothetical protein, similar to P95263|Rv1951c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (137 aa), FASTA scores: opt: 271, E(): 1.5e-11, (51.04% identity in 97 aa overlap); and some similarity with P95012|Rv2541 HYPOTHETICAL ALANINE RICH PROTEIN from Mycobacterium tuberculosis (135 aa), FASTA scores: opt: 140, E(): 0.014, (32.95% identity in 88 aa overlap).; hypothetical protein	complement(2334295..2334594)	Mycobacterium tuberculosis H37Rv	3205060
NP_216594.1	CDS	Rv2078	NC_000962.2	2335059	2335373	D	Rv2078, (MTCY49.17), len: 104 aa. Unknown; hypothetical protein	2335059..2335373	Mycobacterium tuberculosis H37Rv	888071
NP_216595.1	CDS	Rv2079	NC_000962.2	2335355	2337325	D	Rv2079, (MTCY49.18), len: 656 aa. Conserved hypothetical protein; part of Mycobacterium tuberculosis protein family with Rv2542, Rv2077c, Rv2797c, Rv0963c, Rv1949c. Contains PS00120 Lipases, serine active site; hypothetical protein	2335355..2337325	Mycobacterium tuberculosis H37Rv	887333
NP_216596.1	CDS	lppJ	NC_000962.2	2337306	2337869	D	Rv2080, (MTCY49.19), len: 187 aa. Possible lppJ, lipoprotein; contains prokayotic lipoprotein modification site (PS00013) and signal sequence at N-terminus.; lipoprotein LppJ	2337306..2337869	Mycobacterium tuberculosis H37Rv	887351
NP_216597.1	CDS	Rv2081c	NC_000962.2	2338065	2338505	R	Rv2081c, (MTCY49.20c), len: 146 aa. Possible transmembrane unknown protein. Hydrophobic stretch from aa 32-54.; transmembrane protein	complement(2338065..2338505)	Mycobacterium tuberculosis H37Rv	887348
NP_216598.1	CDS	Rv2082	NC_000962.2	2338709	2340874	D	Rv2082, (MTCY49.21), len: 721 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0029, and to Rv3899c and Rv3900c which may be frameshifted.; hypothetical protein	2338709..2340874	Mycobacterium tuberculosis H37Rv	887795
NP_216599.1	CDS	Rv2083	NC_000962.2	2340871	2341815	D	Rv2083, (MTCY49.22), len: 314 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv3898c (110 aa) and Rv3897c (210 aa); hypothetical protein	2340871..2341815	Mycobacterium tuberculosis H37Rv	887281
NP_216600.1	CDS	Rv2084	NC_000962.2	2341808	2342944	D	Rv2084, (MTCY49.23), len: 378 aa. Hypothetical unknown protein.; hypothetical protein	2341808..2342944	Mycobacterium tuberculosis H37Rv	887350
NP_216601.1	CDS	Rv2085	NC_000962.2	2343027	2343332	D	Rv2085, (MTCY49.24), len: 101 aa. Conserved hypothetical protein, similar to YI32_MYCTU P19772 insertion element IS986 hypothetical 6.6 kda protein (59 aa), FASTA scores, opt: 119, E(): 0.002 9, (36.4% identity in 55 aa overlap); ORFs Rv2085, Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) all show similarity to transposases but we can find no sequence errors to account for the frameshifts. Contains possible helix-turn-helix motif at aa 33 to 54,(+3.11 SD).; hypothetical protein	2343027..2343332	Mycobacterium tuberculosis H37Rv	888138
NP_216602.2	CDS	Rv2086	NC_000962.2	2343311	2343916	D	Rv2086, (MTCY49.25), len: 201 aa. Conserved hypothetical protein: low similarity to transposases; ORFs Rv2085, Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) all show similarity to transposases but we can find no sequence errors to account for the frameshifts. Start changed since first submission (-16 aa).; hypothetical protein	2343311..2343916	Mycobacterium tuberculosis H37Rv	888128
NP_216603.2	CDS	Rv2087	NC_000962.2	2343994	2344224	D	Rv2087, (MTCY49.27), len: 76 aa. Conserved hypothetical protein, with low similarity to transposases; ORFs Rv2085, Rv2086 and Rv2087 (MTCY49.24,25,26, and 27) all show similarity to transposases but we can find no sequence errors to account for the frameshifts. Start changed since first submission (-45 aa).; hypothetical protein	2343994..2344224	Mycobacterium tuberculosis H37Rv	887934
NP_216604.1	CDS	pknJ	NC_000962.2	2344411	2346180	D	Rv2088, (MTCY49.28), len: 589 aa. Probable pknJ, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to other serine/threonine-protein kinases e.g. PKWA_THECU|P49695 putative serine/threonine-protein kinase (742 aa), FASTA scores: opt: 457, E(): 2.7e-15, (26.0% identity in 578 aa overlap); etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. Experimental studies show evidence of auto-phosphorylation.; transmembrane serine/threonine-protein kinase J	2344411..2346180	Mycobacterium tuberculosis H37Rv	888322
NP_216605.1	CDS	pepE	NC_000962.2	2346197	2347324	R	Rv2089c, (MTCY49.29c), len: 375 aa. Probable pepE, dipeptidase, similar to e.g. PEPQ_LACDL P46545, xaa-pro dipeptidase (368 aa), FASTA scores, opt: 617, E(): 5.1 e-32, (34.7% identity in 363 aa overlap); contains PS00491 Aminopeptidase P and proline dipeptidase signature. Also similar to Mycobacterium tuberculosis peptidases Rv2861c, Rv0734, Rv2535c.; dipeptidase PepE	complement(2346197..2347324)	Mycobacterium tuberculosis H37Rv	887719
NP_216606.1	CDS	Rv2090	NC_000962.2	2347373	2348554	D	Rv2090, (MTCY49.30), len: 393 aa. Probable 5'-3' exonuclease (EC 3.1.11.-), similar to exonuclease part of DNA polymerase, e.g. DPO1_MYCTU Q07700 DNA polymerase I (EC 2.7.7.7) (pol i) (904 aa), FASTA scores, opt: 461, E(): 1.2e-17, (38.7% identity in 292 aa overlap). BELONGS TO FAMILY A OF DNA POLYMERASES; 5'-3' exonuclease	2347373..2348554	Mycobacterium tuberculosis H37Rv	887924
NP_216607.1	CDS	Rv2091c	NC_000962.2	2348558	2349292	R	Rv2091c, (MTCY49.31c), len: 244 aa. Probable membrane protein; contains potential transmembrane region. Repetitive ORF.; hypothetical protein	complement(2348558..2349292)	Mycobacterium tuberculosis H37Rv	887469
NP_216608.1	CDS	helY	NC_000962.2	2349334	2352054	R	Rv2092c, (MTCY49.32c), len: 906 aa. Probable helY, DNA helicase (EC 3.6.1.-), with similarity to YJF0_YEAST P47047 hypothetical helicase in tdh1-gyp6 intergenic region, (1073 aa), FASTA scores, opt: 1004, E(): 0, (29.0% identity in 970 aa o verlap); contains PS00017 ATP/GTP-binding site motif A, PS00402 Binding-protein-dependent transport systems inner membrane comp signature. BELONGS TO THE SKI2 SUBFAMILY OF HELICASES.; ATP-dependent DNA helicase HelY	complement(2349334..2352054)	Mycobacterium tuberculosis H37Rv	887736
NP_216609.1	CDS	tatC	NC_000962.2	2352103	2353029	R	Rv2093c, (MT2154, MTCY49.33c), len: 308 aa. Probable tatC, transmembrane protein, component of twin-arginine translocation protein export system (see citation below), equivalent to U00017|U00017_1 from Mycobacterium leprae (317 aa), FASTA scores: opt: 1722, E(): 0, (84.5% identity in 310 aa overlap). Similarity to others e.g. P27857|TATC_ECOLI|MTTB|B3839|Z5360|ECS4768 Sec-independent protein translocase protein from E. coli strain K12 and O157:H7 (258 aa), FASTA scores: opt: 344, E(): 6e-16, (32.5% identity in 265 aa overlap). BELONGS TO THE TATC FAMILY.; Sec-independent protein translocase transmembrane protein tatC	complement(2352103..2353029)	Mycobacterium tuberculosis H37Rv	888068
NP_216610.1	CDS	tatA	NC_000962.2	2353046	2353297	R	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A	complement(2353046..2353297)	Mycobacterium tuberculosis H37Rv	888086
NP_216611.1	CDS	Rv2095c	NC_000962.2	2353365	2354315	R	Rv2095c, (MTCY49.35c), len: 316 aa. Conserved hypothetical protein. Highly similar to ML1330 P54075|YY35_MYCLE HYPOTHETICAL 27.0 kDa PROTEIN (247 aa) opt: 1127 E(): 0, (78.4% identity in 227 aa overlap). Also similar to ORF11(1) of Rhodococcus erythropolis. FASTA score: Z82004|REZ820043 REZ82004 NID: g1666179 - Rhodococcus (326 aa) opt: 624 E(): 1.1e-30; (56.7% identity in 319 aa overlap). Contains possible helix-turn-helix motif at aa 25-46, ( +2.92 SD); hypothetical protein	complement(2353365..2354315)	Mycobacterium tuberculosis H37Rv	888403
NP_216612.1	CDS	Rv2096c	NC_000962.2	2354312	2355310	R	Rv2096c, (MTCY49.36c), len: 332 aa. Conserved hypothetical protein. Highly similar to ML1329, P54076|YY36_MYCLE HYPOTHETICAL 35.4 kDa PROTEIN B21 (331 aa) opt: 1676 E(): 0; (80.2% identity in 329 aa overlap) and to ORF10(1) of Rhodococcus erythropolis, Z82004|REZ820042 REZ 82004 NID: g1666179 (330 aa) opt: 1232, E(): 0; 59.9% identity in 332 aa overlap; hypothetical protein	complement(2354312..2355310)	Mycobacterium tuberculosis H37Rv	888436
NP_216613.1	CDS	Rv2097c	NC_000962.2	2355319	2356677	R	Rv2097c, (MTCY49.37c), len: 452 aa. Conserved hypothetical protein. Similarity to YTH6_ RHOSO P43484 hypothetical protein in thcr 5' region (333 aa), FASTA scores opt: 738, E(): 0, (38.5% identity in 330 aa overlap). Also highly similar to Mycobacterium leprae protein ML1328, P54077|YY37_MYCLE HYPOTHETICAL 38.1 KD PROTEIN (336 aa) opt: 1985 E(): 0; (96.4% identity in 307 aa overlap); hypothetical protein	complement(2355319..2356677)	Mycobacterium tuberculosis H37Rv	888460
NP_216616.1	CDS	Rv2100	NC_000962.2	2358389	2360041	D	Rv2100, (MTCY49.40), len: 550 aa. Conserved hypothetical protein. Member of Mycobacterium tuberculosis REP13E12 repeat family with Rv1148c, Rv1945, Rv3467, Rv0094c, Rv1128c, Rv1587c, Rv1702c, Rv3466, Rv1588c.; hypothetical protein	2358389..2360041	Mycobacterium tuberculosis H37Rv	888454
NP_216617.1	CDS	helZ	NC_000962.2	2360240	2363281	D	Rv2101, (MTV020.01), len: 1013 aa. Probable helZ, helicase (EC 3.6.-.-), similar to many e.g. PCC6803|P74552|SLL1366 HELICASE OF THE SNF2/RAD54 FAMILY from Synechocystis sp. strain PCC 6803 (1039 aa), FASTA scores: opt: 2015, E(): 0, (38.4% identity in 1063 aa overlap); etc. TBparse score is 0.875.; helicase HelZ	2360240..2363281	Mycobacterium tuberculosis H37Rv	888635
NP_216618.1	CDS	Rv2102	NC_000962.2	2363391	2364107	D	Rv2102, (MTV020.02), len: 238 aa. Conserved hypothetical protein, similar to part of hypothetical protein D90916|D90916_18 from Synechocystis sp. PCC6803 (289 aa), FASTA scores: opt: 498, E(): 1.9e-25, (46.7% identity in 167 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.884.; hypothetical protein	2363391..2364107	Mycobacterium tuberculosis H37Rv	888639
NP_216619.1	CDS	Rv2103c	NC_000962.2	2364086	2364520	R	Rv2103c, (MTV020.03), len: 144 aa. Conserved hypothetical protein, similar to hypothetical mycobacterial proteins belonging to family, includes Rv0749, Rv0277c, Rv2530c, Rv3320c, Rv2494, Rv2872, Rv0617, Rv1242 etc. FASTA scores: sptr|Q49793|Q49793 B2126_C3_261 (97 aa) opt: 331, E(): 4.8e-18; 59.4% identity in 96 aa overlap and gp|Z74024|MTCY274_3 Mycobacterium tuberculosis cosmid (147 aa) opt: 234, E(): 1.2e-10; 34.8% identity in 141 aa overlap. TBparse score is 0.889; hypothetical protein	complement(2364086..2364520)	Mycobacterium tuberculosis H37Rv	888003
NP_216620.1	CDS	Rv2104c	NC_000962.2	2364527	2364781	R	Rv2104c, (MTV020.04), len: 84 aa. Conserved hypothetical protein, similar to members of a family of hypothetical mycobacterial proteins including Rv2871, Rv1241, Rv2132, Rv3321c, Rv1113, Rv0657, Rv1560, etc. FASTA scores: sptr|Q49787|Q49787 B2126_C2_217 (97 aa) opt: 197, E(): 2e-07; 57.1% identity in 56 aa overlap and Z95388|MTCY270_36 Mycobacterium tuberculosis cosmid (76 aa ) opt: 142, E(): 0.0011; 41.8% identity in 55 aa overlap. TBparse score is 0.915; hypothetical protein	complement(2364527..2364781)	Mycobacterium tuberculosis H37Rv	888014
NP_216621.1	CDS	Rv2105	NC_000962.2	2365465	2365791	D	Rv2105, (MTCY261.01), len: 108 aa. Probable transposase subunit for IS6110, similar to eg. Q51647|IS401 transposase subunit (107 aa), FASTA scores; opt: 325, E(): 3.8e-24, (52.9% identity in 102 aa overlap). Identical to many other Mycobacterium tuberculosis IS6110 transposase subunits.; transposase	2365465..2365791	Mycobacterium tuberculosis H37Rv	888395
NP_216622.1	CDS	Rv2106	NC_000962.2	<2365788	2366726	D	Rv2106, (MTCY261.02), len: 312 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits.; transposase	<2365788..2366726	Mycobacterium tuberculosis H37Rv	888398
YP_177858.1	CDS	PE22	NC_000962.2	2367359	2367655	D	Rv2107, (MTCY261.03), len: 98 aa. Member of mycobacterial PE family (see citation below), e.g. Y03A_MYCTU Q10637 hypothetical glycine-rich 49.6 kDa protein (603 aa), FASTA scores; opt: 214 E(): 1.3e-14, (39.8% identity in 93 aa overlap).; PE family protein	2367359..2367655	Mycobacterium tuberculosis H37Rv	887811
YP_177859.1	CDS	PPE36	NC_000962.2	2367711	2368442	D	Rv2108, (MTCY261.04), len: 243 aa. Member of the Mycobacterium tuberculosis PE family: N-terminus is similar to N-terminal region of Mycobacterium tuberculosis PPE family proteins, e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein (404 aa), FASTA scores: opt: 431, E(): 3.9e-32, (44.0% identity in 166 aa overlap).; PPE family protein	2367711..2368442	Mycobacterium tuberculosis H37Rv	887814
NP_216625.1	CDS	prcA	NC_000962.2	2368983	2369729	R	Rv2109c, (MTCY261.05c), len: 248 aa. prcA, proteasome alpha-type subunit 1, highly similar to TR:Q53080 (EMBL:U26421 ) proteasome alpha-type subunit 1 from Rhodococcus (259 aa), FASTA scores; opt: 1035, E(): 0, 67.2% identity in 247 aa overlap.; proteasome (alpha subunit) PrcA	complement(2368983..2369729)	Mycobacterium tuberculosis H37Rv	887538
NP_216626.1	CDS	prcB	NC_000962.2	2369726	2370601	R	Rv2110c, (MTCY261.06c), len: 291 aa. prcB, proteasome beta-type subunit 2, highly similar to eg. TR:Q53083 (EMBL:U264 22) proteasome beta-type subunit 2 from Rhodococcus (292 aa), FASTA scores; opt: 1103, E(): 0, 64.5% identity in 262 aa overlap.; proteasome (beta subunit) PrcB	complement(2369726..2370601)	Mycobacterium tuberculosis H37Rv	887508
NP_216627.1	CDS	Rv2111c	NC_000962.2	2370598	2370792	R	Rv2111c, MTCY261.07c, len: 64 aa. Conserved hypothetical protein. Highly similar to a hypothetical protein TR:Q53078 (EMBL:U26422) (64 aa) upstream of Rhodococcus proteasome beta-type subunit 1, FASTA scores; opt: 349, E(): 7.3e-25, 84.4% identity in 64 aa overlap; hypothetical protein	complement(2370598..2370792)	Mycobacterium tuberculosis H37Rv	888788
NP_216628.1	CDS	Rv2112c	NC_000962.2	2370905	2372569	R	Rv2112c, (MTCY261.08c), len: 554 aa. Conserved hypothetical protein. Highly similar to a hypothetical protein TR:Q53081 (EMBL:U26422) (499 aa) upstream of Rhodococcus proteasome beta-type subunit 1, FASTA scores opt: 2832 E(): 0, 85.3% identity in 502 aa overlap. Also some similarity to Mycobacterium tuberculosis hypothetical protein Rv2097c (MTCY49.37c, 38.2% identity in 419 aa overlap); hypothetical protein	complement(2370905..2372569)	Mycobacterium tuberculosis H37Rv	888290
NP_216629.1	CDS	Rv2113	NC_000962.2	2372630	2373823	D	Rv2113, (MTCY261.09), len: 397 aa. Probable integral membrane protein.; integral membrane protein	2372630..2373823	Mycobacterium tuberculosis H37Rv	887731
NP_216630.1	CDS	Rv2114	NC_000962.2	2373834	2374457	D	Rv2114, (MTCY261.10), len: 207 aa. Unknown hypothetical protein.; hypothetical protein	2373834..2374457	Mycobacterium tuberculosis H37Rv	887803
NP_216631.1	CDS	Rv2115c	NC_000962.2	2374461	2376290	R	Rv2115c, (MTCY261.11c), len: 609 aa. Probable ATPase (EC 3.6.1.-), similar to e.g. YB56_METJA Q58556 cell division cycle protein 48 homolog (903 aa), FASTA scores; opt: 423, E(): 8.1e-32, 45.8% identity in 249 aa overlap. Contains PS00674 AAA-protein family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Also some similarity to other Mycobacterium tuberculosis ATPases e.g. Rv0435c and Rv3610c. Equivalent to Mycobacterium leprae U00 017|U00017_18 (609 aa), FASTA scores; opt: 3670 E(): 0; 92.9% identity in 609 aa overlap.; ATPase	complement(2374461..2376290)	Mycobacterium tuberculosis H37Rv	887297
NP_216632.1	CDS	lppK	NC_000962.2	2376571	2377140	D	Rv2116, (MTCY261.12), len: 189 aa. Probable lppK, conserved lipoprotein, similar to Mycobacterium leprae B2126_F3_115 TR:Q49803 (194 aa), FASTA scores; opt: 624, E(): 3.1e-31, 51.6% identity in 190 aa overlap. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some similarity to Rv2376c.; lipoprotein lppK	2376571..2377140	Mycobacterium tuberculosis H37Rv	886029
NP_216633.1	CDS	Rv2117	NC_000962.2	2377148	2377441	D	Rv2117, (MTCY261.13), len: 97 aa. Conserved hypothetical protein. Similar to hypothetical proteins from Mycobacterium leprae TR:Q49798 U2126J (97 aa), FASTA scores; opt: 554, E(): 0, 85.6% identity in 97 aa overlap, and Bacillus subtilis YLXP_BACSU P32730 hypothetical 10.7 kDa protein (92 aa), FASTA scores; opt: 173, E(): 1.4e-11, 34.1% identity in 82 aa overlap; hypothetical protein	2377148..2377441	Mycobacterium tuberculosis H37Rv	887685
NP_216634.1	CDS	Rv2118c	NC_000962.2	2377470	2378312	R	Rv2118c, (MTCY261.14c), len: 280 aa. Possible S-adenosyl-l-methionine-dependent RNA methyltransferase (EC 2.1.1.-) (see citation below); corresponds to Mycobacterium leprae B2126_C1_165, similar to hypothetical proteins from several organisms e.g. Y134_METJA Q57598 hypothetical protein mj0134 (282 aa), FASTA scores; opt: 256, E(): 1e-13, FASTA scores; 30.2% identity in 285 aa overlap. The larger catalytic C-terminal domain binds the cofactor S-adenosyl-l-methionine (AdoMet) and is involved in the transfer of methyl group from AdoMet to the substrate.; RNA methyltransferase	complement(2377470..2378312)	Mycobacterium tuberculosis H37Rv	887374
NP_216635.1	CDS	Rv2119	NC_000962.2	2378386	2379222	D	Rv2119, (MTCY261.15), len: 278 aa. Conserved hypothetical protein. Similar to Mycobacterium leprae hypothetical protein TR:Q49799 U2126V (212 aa), FASTA scores; opt: 1153, E(): 0, 83.6% identity in 195 aa overlap. Orthologs present in Rhodococcus erythropolis (gb|AAC68687.1|(AF088800) and Streptomyces emb|CAB59506.1|(AL132648); hypothetical protein	2378386..2379222	Mycobacterium tuberculosis H37Rv	888413
NP_216636.1	CDS	Rv2120c	NC_000962.2	2379245	2379727	R	Rv2120c, (MTCY261.16c), len: 160 aa. Probable conserved integral membrane protein, similar to hypothetical protein from Mesorhizobium loti (153 aa). Smith-Waterman scores: NP_104030.1 hypothetical protein [Mesorhizobium loti] >gi|14023209|dbj|BAB49816.1| (AP003000) Identities = 50/135 (37%).; integral membrane protein	complement(2379245..2379727)	Mycobacterium tuberculosis H37Rv	887821
NP_216637.1	CDS	hisG	NC_000962.2	2379806	2380660	R	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase	complement(2379806..2380660)	Mycobacterium tuberculosis H37Rv	888689
YP_177860.1	CDS	hisE	NC_000962.2	2380663	2380944	R	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase	complement(2380663..2380944)	Mycobacterium tuberculosis H37Rv	888671
YP_177861.1	CDS	PPE37	NC_000962.2	2381071	2382492	D	Rv2123, (MTCY261.19), len: 473 aa. PPE37 (alternate gene name: irg2), member of the Mycobacterium tuberculosis PPE family of proteins but the C-terminus is not repetitive (see citation below).; irg2; PPE family protein	2381071..2382492	Mycobacterium tuberculosis H37Rv	888710
NP_216640.1	CDS	metH	NC_000962.2	2382489	2386067	R	Rv2124c, (MTCY261.20c), len: 1192 aa. Probable metH, methionine synthase (EC 2.1.1.13), similar to many e.g. METH_ECOLI|P13009 5-methyltetrahydrofolate--homocystein methyltransferase from Escherichia coli (1226 aa), FASTA scores: opt: 1446, E(): 0, (32.1% identity in 1223 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO THE VITAMIN-B12 DEPENDENT METHIONINE SYNTHASE FAMILY.; 5-methyltetrahydrofolate--homocystein methyltransferase	complement(2382489..2386067)	Mycobacterium tuberculosis H37Rv	888711
NP_216641.1	CDS	Rv2125	NC_000962.2	2386293	2387171	D	Rv2125, (MTCY261.21), len: 292 aa. Conserved hypothetical protein. Corresponds to Mycobacterium leprae hypothetical protein e.g. TR:Q49797 B2126_F1_36 (317 aa), FASTA scores; opt: 1648, E(): 0, 84.1% identity in 290 aa overlap. Very similar to Mycobacterium tuberculosis hypothetical protein Rv2714; hypothetical protein	2386293..2387171	Mycobacterium tuberculosis H37Rv	887798
YP_177862.1	CDS	PE_PGRS37	NC_000962.2	2387202	2387972	R	Rv2126c, (MTCY261.22c), len: 256 aa. Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family e.g. MTCY441.04c (778 aa), FASTA scores; opt: 935, E(): 4.4e-18, 56.1% identity in 271 aa overlap.; PE-PGRS family protein	complement(2387202..2387972)	Mycobacterium tuberculosis H37Rv	887791
YP_177863.1	CDS	ansP1	NC_000962.2	2388616	2390085	D	Rv2127, (MTCY261.26), len: 489 aa. Probable ansP1, L-asparagine permease, integral membrane protein highly similar to many e.g. ANSP_ECOLI P77610 L-asparagine permease (L-asparagine transport protein) (516 aa), FASTA scores: opt: 1880, E(): 0, (60.3% identity in 463 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis permeases Rv0346c|MTCY13E10.06c, (72.1% identity in 473 aa overlap) and Rv1704c|MTCI125.26c|cycA. Contains PS00218 Amino acid permeases signature. SEEMS TO BELONG TO THE APC FAMILY.; L-asparagine permease ansP1	2388616..2390085	Mycobacterium tuberculosis H37Rv	887715
NP_216644.1	CDS	Rv2128	NC_000962.2	2390085	2390288	D	Rv2128, (MTCY26.27), len: 67 aa. Probable conserved transmembrane protein.; transmembrane protein	2390085..2390288	Mycobacterium tuberculosis H37Rv	887764
NP_216645.1	CDS	Rv2129c	NC_000962.2	2390308	2391189	R	Rv2129c, (MTCY261.28), len: 293 aa. Probable oxidoreductase (EC 1.-.-.-), similar to many e.g. FABG_SYNY3|P73826 3-oxoacyl-[acyl-carrier protein] reductase (240 aa), FASTA scores: opt: 241, E(): 5.1e-17, (32.7% identity in 196 aa overlap); etc. Also similar to a number of other Mycobacterium tuberculosis oxidoreductases e.g. MTCY210.04 (34.1% identity in 217 aa overlap).; short chain dehydrogenase	complement(2390308..2391189)	Mycobacterium tuberculosis H37Rv	887841
NP_216646.1	CDS	cysS	NC_000962.2	2391215	2392459	R	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase	complement(2391215..2392459)	Mycobacterium tuberculosis H37Rv	887492
NP_216647.1	CDS	cysQ	NC_000962.2	2392517	2393320	R	Rv2131c, (MTCY270.37), len: 267 aa. Possible cysQ, monophosphatase, equivalent to CYSQ_MYCLE|P46726 cysQ protein homolog from Mycobacterium leprae (289 aa), FASTA scores: opt: 1374, E(): 0, (77.3% identity in 264 aa overlap). Contains inositol monophosphatase family signature 1 (PS00629), significance uncertain. SEEMS TO BELONG TO THE INOSITOL MONOPHOSPHATASE FAMILY.; monophosphatase CysQ	complement(2392517..2393320)	Mycobacterium tuberculosis H37Rv	888142
NP_216648.1	CDS	Rv2132	NC_000962.2	2393411	2393641	D	Rv2132, (MTCY270.36c), len: 76 aa. Conserved hypothetical protein. Function unknown but belongs to Mycobacterium tuberculosis protein family including Rv2871, Rv1241, Rv3321c, Rv1113, Rv0657c, Rv1560, Rv2104c, etc. Similarity to Mycobacterium tuberculosis protein Rv2871 (AL021924|MTV020_4, 84 aa). FASTA score: opt: 142, E(): 0.00036; 41.8% identity in 55 aa overlap; hypothetical protein	2393411..2393641	Mycobacterium tuberculosis H37Rv	887827
NP_216649.1	CDS	Rv2133c	NC_000962.2	2393851	2394639	R	Rv2133c, (MTCY270.35), len: 262 aa. Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49774. FASTA best: Q49774 B2126_C1_150 (262 aa) opt: 1447, E(): 0; (79.0% identity in 262 aa overlap); hypothetical protein	complement(2393851..2394639)	Mycobacterium tuberculosis H37Rv	887616
NP_216650.1	CDS	Rv2134c	NC_000962.2	2394650	2395237	R	Rv2134c, (MTCY270.34), len: 195 aa. Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49789. FASTA best: Q49789 B2126_C3_228, opt: 1192, E( ): 0 (91.1% identity in 192 aa overlap); hypothetical protein	complement(2394650..2395237)	Mycobacterium tuberculosis H37Rv	887844
NP_216651.1	CDS	Rv2135c	NC_000962.2	2395301	2396011	R	Rv2135c, (MTCY270.33), len: 236 aa. Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49773. FASTA best: Q49773 B2126_C1_148 opt: 1183, E() : 0; (74.8% identity in 250 aa overlap), also similar in C-terminus to PMG2_ECOLI P36942 probable phosphoglycerate mutase 2 (215 aa), FASTA scores; opt: 212, E(): 2.5e-07 27.9% identity in 190 aa overlap; and to Rv2228 and Rv2419c; hypothetical protein	complement(2395301..2396011)	Mycobacterium tuberculosis H37Rv	887273
NP_216652.1	CDS	uppP	NC_000962.2	2396008	2396838	R	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase	complement(2396008..2396838)	Mycobacterium tuberculosis H37Rv	887612
NP_216653.1	CDS	Rv2137c	NC_000962.2	2396902	2397315	R	Rv2137c, (MTCY270.31), len: 137 aa. Conserved hypothetical protein. C-terminus is very similar to hypothetical Mycobacterium leprae protein B2126_C2_188 (150 aa). FASTA best: Q49782 B2126_C2_188. (150 aa) opt: 469, E(): 9.6e-28; (77.2% identity in 101 aa overlap); hypothetical protein	complement(2396902..2397315)	Mycobacterium tuberculosis H37Rv	888009
NP_216654.1	CDS	lppL	NC_000962.2	2397330	2398406	D	Rv2138, (MTCY270.30c), len: 358 aa. Probable lppL, conserved lipoprotein, with appropriately placed lipoprotein signature (PS00013) strongly similar to hypothetical Mycobacterium leprae protein, Q49806. FASTA best: Q49806 B2126_F3_142. (298 aa) opt: 1495, E(): 0; (75.3% identity in 300 aa overlap).; lipoprotein LppL	2397330..2398406	Mycobacterium tuberculosis H37Rv	887303
NP_216655.1	CDS	pyrD	NC_000962.2	2398720	2399793	D	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2	2398720..2399793	Mycobacterium tuberculosis H37Rv	887326
NP_216656.1	CDS	TB18.6	NC_000962.2	2399798	2400328	R	Rv2140c, (MTCY270.28), len: 176 aa. TB18.6, conserved hypothetical protein; shows good similarity to hypothetical proteins from Streptomyces coelicolor (177 aa; 58% identity) >emb|CAC32358.1| (AL583945) and to 17.1 kDa Escherichia coli protein YbhB. FASTA best: YBHB_ECOLI P12994 hypothetical 17.1 kDa protein (158 aa) opt: 465 E( ): 2e-23; (46.2% identity in 156 aa overlap).; hypothetical protein	complement(2399798..2400328)	Mycobacterium tuberculosis H37Rv	888118
YP_177864.1	CDS	Rv2141c	NC_000962.2	2400376	2401722	R	Rv2141c, (MTCY270.27), len: 448 aa. Conserved hypothetical protein. Shows some similarity to conserved hypothetical proteins and to acetylornithine deacetylase and succinyl-diaminopimelate desuccinylase and contains ArgE/dapE/ACY1/CPG2/yscS family signature 1 (PS00758). FASTA best: CBPS_YEAST P27614 carboxypeptidases precursor (576 aa) opt: 234, E(): 4.3e-08; (24.3% identity in 412 aa overlap). Previously named dapE2; dapE2; hypothetical protein	complement(2400376..2401722)	Mycobacterium tuberculosis H37Rv	887384
NP_216658.1	CDS	Rv2142c	NC_000962.2	2402193	2402510	R	Rv2142c, (MTCY270.26), len: 105 aa. Hypothetical unknown protein.; hypothetical protein	complement(2402193..2402510)	Mycobacterium tuberculosis H37Rv	888770
NP_216659.1	CDS	Rv2143	NC_000962.2	2402977	2404035	D	Rv2143, (MTCY270.25c), len: 352 aa. Conserved hypothetical protein, strongly similar to two hypothetical mycobacterial proteins Rv2030c 2.1e-50 and Rv0571c from position 120 (Q50819; Q50111). FASTA best: Q50819 opt: 882, E() 0; (61.1% identity in 226 aa overlap). Also similar to AL021942|MTV039_9 (443 aa), FASTA scores: opt: 592, E(): 5e-30; 46.9% identity in 224 aa overlap; hypothetical protein	2402977..2404035	Mycobacterium tuberculosis H37Rv	887406
NP_216660.1	CDS	Rv2144c	NC_000962.2	2404165	2404521	R	Rv2144c, (MTCY270.24), len: 118 aa. Probable transmembrane protein.; transmembrane protein	complement(2404165..2404521)	Mycobacterium tuberculosis H37Rv	888202
NP_216661.1	CDS	wag31	NC_000962.2	2404616	2405398	R	Rv2145c, (MTCY270.23), len: 260 aa. wag31 (alternate gene name: ag84). Function unknown but corresponds to antigen 84 of Mycobacterium tuberculosis (wag31) (see Hermans et al., 1995). Predicted to contain significant amount of coiled coil structure. Some similarity to Rv1682 and Rv2927c. FASTA best: AG84_MYCTU P46816 antigen 84.; ag84; hypothetical protein	complement(2404616..2405398)	Mycobacterium tuberculosis H37Rv	888224
NP_216662.1	CDS	Rv2146c	NC_000962.2	2405666	2405956	R	Rv2146c, (MTCY270.22), len: 96 aa. Possible conserved transmembrane protein, orthologs present in M. leprae, ML0921 (96 aa) and Streptomyces coelicolor. Second start taken GTG alternative upstream but much less probable in TBparse. FASTA best: Q44935 SIMILAR TO A HYPOTHETICAL INTEGRAL MEMBRANE PROT EIN (97 aa) opt: 105, E(): 0.093; (25.3% identity in 87 aa overlap). >emb|CAC31302.1| (AL583920) possible membrane protein ML0921 [Mycobacterium leprae] E(): 5e-32 (76% identity in 96 aa overlap); transmembrane protein	complement(2405666..2405956)	Mycobacterium tuberculosis H37Rv	888759
NP_216663.1	CDS	Rv2147c	NC_000962.2	2406118	2406843	R	Rv2147c, (MTCY270.21), len: 241 aa. Conserved hypothetical protein, similar to conserved hypothetical proteins in Mycobacterium leprae ML0920 (210 aa) and Streptomyces coelicolor. FASTA scores: >emb|CAC31301.1| (AL583920) hypothetical protein ML0920 hypothetical protein (210 aa) opt: 1242, E(): 5.7e-74; 83.486% identity in 218 aa overlap; hypothetical protein	complement(2406118..2406843)	Mycobacterium tuberculosis H37Rv	887394
NP_216664.1	CDS	Rv2148c	NC_000962.2	2406840	2407616	R	Rv2148c, (MTCY270.20), len: 258 aa. Conserved hypothetical protein; should belong to the YGGS/YBL036C/F09E5.8 family. FASTA best: AB003132|AB003132_5 Corynebacterium glutamicum gene (221 aa) opt: 440, E(): 2.3e-23; 42.8% identity in 236 aa overlap; and YPI1_VIBAL P52055 hypothetical protein in pilt-proc intergenic region in Vibrio alginolyticus. opt: 266, E(): 1.8e-11; 27.9% identity in 244 aa overlap. TBparse score is 0.940; hypothetical protein	complement(2406840..2407616)	Mycobacterium tuberculosis H37Rv	888127
NP_216665.1	CDS	yfiH	NC_000962.2	2407622	2408374	R	Rv2149c, (MTCY270.19), len: 250 aa. yfiH; corresponds to hypothetical 25.3 kDa YfiH protein in ftsZ 3' region of Streptomyces griseus, and to YfiH proteins in other bacteria. Belongs to UPF0124 Family. FASTA best: YFIH_STRGR P45496, (246 aa) opt: 722, E(): 1.9e-37; (49.4% identity in 245 aa overlap); hypothetical protein	complement(2407622..2408374)	Mycobacterium tuberculosis H37Rv	888121
NP_216666.1	CDS	ftsZ	NC_000962.2	2408385	2409524	R	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ	complement(2408385..2409524)	Mycobacterium tuberculosis H37Rv	888369
NP_216667.1	CDS	ftsQ	NC_000962.2	2409697	2410641	R	Rv2151c, (MTCY270.17), len: 314 aa. Possible ftsQ, cell division protein, with some homology to FTSQ_STRGR|P45503 cell division protein ftsq homolog from Streptomyces griseus (208 aa), FASTA scores: opt: 204, E(): 4e-05; (30.6% identity in 193 aa overlap).; cell division protein FtsQ	complement(2409697..2410641)	Mycobacterium tuberculosis H37Rv	888367
NP_216668.1	CDS	murC	NC_000962.2	2410638	2412122	R	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase	complement(2410638..2412122)	Mycobacterium tuberculosis H37Rv	887983
NP_216669.1	CDS	murG	NC_000962.2	2412119	2413351	R	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase	complement(2412119..2413351)	Mycobacterium tuberculosis H37Rv	888036
NP_216670.1	CDS	ftsW	NC_000962.2	2413348	2414922	R	Rv2154c, (MTCY270.14), len: 524 aa. Probable ftsW, cell division protein, related to MTCY10H4.17c, 3.2e-17. FASTA best: SP5E_BACSU P07373 stage V sporulation protein E (366 aa) opt: 755, E(): 1.6e-33; (38.4% identity in 357 aa overlap); FtsW-like protein FtsW	complement(2413348..2414922)	Mycobacterium tuberculosis H37Rv	887916
NP_216671.1	CDS	murD	NC_000962.2	2414934	2416394	R	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase	complement(2414934..2416394)	Mycobacterium tuberculosis H37Rv	888000
NP_216672.1	CDS	mraY	NC_000962.2	2416396	2417475	R	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase	complement(2416396..2417475)	Mycobacterium tuberculosis H37Rv	888098
NP_216673.1	CDS	murF	NC_000962.2	2417472	2419004	R	deleted EC_number 6.3.2.15; Rv2157c, (MTCY270.11), len: 510 aa. Probable murF, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate -D -alanyl-D-alanyl ligase (EC 6.3.2.15) (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE) (see citation below), also related to other Mycobacterium tuberculosis mur gene products. FASTA best: MURF_ECOLI|P11880 (452 aa), opt: 515, E(): 2.6e-24, (31.9% identity in 511 aa overlap).; UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate- D-alanyl-D-alanyl ligase MurF	complement(2417472..2419004)	Mycobacterium tuberculosis H37Rv	887826
NP_216674.1	CDS	murE	NC_000962.2	2419001	2420608	R	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase	complement(2419001..2420608)	Mycobacterium tuberculosis H37Rv	887252
NP_216675.1	CDS	Rv2159c	NC_000962.2	2420631	2421665	R	Rv2159c, (MTCY270.09), len: 344 aa. Conserved hypothetical protein; some similarity to hypothetical protein from Streptomyces coelicolor SC1A6.09c (337 aa, 29% identity). Smith-Waterman scores: >pir||T28690 hypothetical protein - Streptomyces coelicolor >gi|3127841|emb|CAA18907.1| (AL023496) Expect = 2e-18; hypothetical protein	complement(2420631..2421665)	Mycobacterium tuberculosis H37Rv	887236
YP_177660.1	CDS	Rv2160A	NC_000962.2	2421643	2422278	R	Rv2160A, len: 211 aa. Conserved hypothetical protein, possibly a tetR-family transcriptional regulator, similar to N-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 aa), FASTA scores: opt: 285, E(): 1.4e-08, (51.042% identity in 96 aa overlap). Next gene, Rv2160c, is similar to C-terminal half of 2SCK31.01c suggesting possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551.; hypothetical protein	complement(2421643..2422278)	Mycobacterium tuberculosis H37Rv	3205077
NP_216676.1	CDS	Rv2160c	NC_000962.2	2421662	2422003	R	Rv2160c, (MTCY270.08), len: 113 aa. Conserved hypothetical protein, possibly a tetR-family transcriptional regulator, similar to C-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 aa), while Rv2160A is similar to the N-terminal half of 2SCK31.01c. This suggests possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551.; hypothetical protein	complement(2421662..2422003)	Mycobacterium tuberculosis H37Rv	886254
NP_216677.1	CDS	Rv2161c	NC_000962.2	2422271	2423137	R	Rv2161c, (MTCY270.07), len: 288 aa. Conserved hypothetical protein; shows some similarity to protein involved in lincomycin production and to other M. tuberculosis proteins e.g. Rv0953c, Rv0791c, Rv0132c, Rv2951c, Rv1855c. FASTA best: Q54379 (78-11) LINCOMYCIN PRODUCTION GENES (295 aa) opt: 243, E(): 2.4e-09; (29.5% identity in 285 aa overlap).; hypothetical protein	complement(2422271..2423137)	Mycobacterium tuberculosis H37Rv	887978
YP_177865.1	CDS	PE_PGRS38	NC_000962.2	2423240	2424838	R	Rv2162c, (MTCY270.06), len: 532 aa. Member of M. tuberculosis PE_PGRS family (see citations below). FASTA score: Y03A_MYCTU Q 10637 hypothetical glycine-rich 49.6 kDa protein (603 aa) op t: 1798 z-score: 1220.0 E(): 0; (55.4% identity in 590 aa overlap); PE-PGRS family protein	complement(2423240..2424838)	Mycobacterium tuberculosis H37Rv	887300
NP_216679.1	CDS	pbpB	NC_000962.2	2425048	2427087	R	Rv2163c, (MTCY270.05), len: 679 aa. Probable pbpB, penicillin-binding membrane protein, similar to many bacterial PBP2 proteins e.g. P11882|PBP2_NEIME|PENA|NMA2072|NMB0413 penicillin-binding protein 2 (pbp-2) from Neisseria meningitidis (serogroups A and B) (581 aa), FASTA scores: opt: 665, E(): 1.6e-31, (33.2% identity in 591 aa overlap); etc. Also similar to Rv0016c and Rv2864c from Mycobacterium tuberculosis (2.8e-10). Contains PS00017 possible ATP/GTP-binding site motif A (P-loop) near C-terminus. FASTA best: PBP2_NEIME P11882 penicillin-binding protein 2 (pbp-2). (581 aa) opt: 665, E(): 1.6e-31; (33 .2% identity in 591 aa overlap); penicillin-binding membrane protein pbpB	complement(2425048..2427087)	Mycobacterium tuberculosis H37Rv	887949
NP_216680.1	CDS	Rv2164c	NC_000962.2	2427084	2428238	R	Rv2164c, (MTCY270.04), len: 384 aa. Probable pro- rich conserved membrane protein, equivalent to ML0907|AL022602 putative conserved membrane protein from Mycobacterium leprae (377 aa) (AL022602), FASTA scores: opt: 1495, E(): 1.7e-56, (62.217% identity in 397 aa overlap).; hypothetical protein	complement(2427084..2428238)	Mycobacterium tuberculosis H37Rv	887217
NP_216681.2	CDS	mraW	NC_000962.2	2428235	2429269	R	Rv2165c, (MTCY270.03), len: 396 aa. Conserved hypothetical protein; shows strong similarity to several hypothetical bacterial proteins but has extra 80 aa residues at N-terminus FASTA best: YLXA_BACSU Q07876 hypothetical 35.3 kDa protein in ftsl (311 aa) opt: 781, E(): 0; (45.6% identity in 296 aa overlap), BELONGS TO THE YABC (E.COLI), YLXA (B.SUBTILIS) FAMILY; S-adenosyl-methyltransferase MraW	complement(2428235..2429269)	Mycobacterium tuberculosis H37Rv	888462
NP_216682.1	CDS	Rv2166c	NC_000962.2	2429427	2429858	R	MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ	complement(2429427..2429858)	Mycobacterium tuberculosis H37Rv	888261
NP_216683.1	CDS	Rv2167c	NC_000962.2	2430159	>2431199	R	Rv2167c, (MTCY270.01), len: 346 aa. Probable IS6110 transposase. FASTA best: TRA9_MYCTU P19774 putative transposase for insertion sequence (identical); transposase	complement(2430159..>2431199)	Mycobacterium tuberculosis H37Rv	888197
NP_216684.1	CDS	Rv2168c	NC_000962.2	2431094	2431420	R	Rv2168c, (MTV021.01c), len: 108 aa. Probable IS6110 transposase. FASTA scores: O08155|O08155 HYPOTHETICAL 12.0 kDa PROTEIN (108 aa) opt: 697, E(): 0, (100.0% identity in 108 aa overlap). TBparse score is 0.928.; transposase	complement(2431094..2431420)	Mycobacterium tuberculosis H37Rv	888459
NP_216685.1	CDS	Rv2169c	NC_000962.2	2431565	2431969	R	Rv2169c, (MTV021.02c), len: 134 aa. Probable conserved transmembrane protein, with orthologs in M. leprae, ML0904 probable membrane protein (134 aa), and Streptomyces coelicolor. FASTA scores with ML0904, opt: 767, E(): 5.1e-43; 86.567% identity in 134 aa overlap. emb|CAA18678.1| (AL022602) >gi|13092974|emb|CAC31285.1| (AL583920). TBparse score is 0.934; transmembrane protein	complement(2431565..2431969)	Mycobacterium tuberculosis H37Rv	888257
NP_216686.1	CDS	Rv2170	NC_000962.2	2432235	2432855	D	Rv2170, (MTV021.03), len: 206 aa. Conserved hypothetical protein, equivalent to hypothetical protein ML0903 (210 aa) from Mycobacterium leprae. FASTA scores: ML0903 conserved hypothetical protein (210 aa) opt: 1045, E(): 9.1e-57; 77.143% identity in 210 aa overlap. >emb|CAA18679.1| (AL022602) >gi|13092973|emb|CAC31284.1| (AL583920). TBparse score is 0.905; hypothetical protein	2432235..2432855	Mycobacterium tuberculosis H37Rv	888170
NP_216687.1	CDS	lppM	NC_000962.2	2432951	2433634	D	Rv2171, (MTV021.04), len: 227 aa. Probable lppM, conserved lipoprotein; contains putative signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Has hydrophobic stretch at C-terminus and also contains PS00225 Crystallins beta and gamma 'Greek key' motif signature. Unknown but equivalent to Mycobacterium leprae lipoprotein ML0902 (239 aa). FASTA scores: opt: 1083, E(): 2.4e-56; 75.446% identity in 224 aa overlap (5-227:16-239) >emb|CAA18680.1| (AL022602) >gi|13092972|emb|CAC31283.1| (AL583920). TBparse score is 0.895; lipoprotein lppM	2432951..2433634	Mycobacterium tuberculosis H37Rv	887522
NP_216688.1	CDS	Rv2172c	NC_000962.2	2433631	2434536	R	Rv2172c, (MTV021.05c), len: 301 aa. Conserved hypothetical protein, equivalent to Mycobacterium leprae conserved hypothetical protein ML0901 (304 aa). FASTA scores: opt: 1656, E(): 7.7e-98; 81.271% identity in 299 aa overlap (1-299:1-299) >emb|CAA18681.1| (AL022602) >gi|13092971|emb|CAC31282.1| (AL583920) . TBparse score is 0.905; hypothetical protein	complement(2433631..2434536)	Mycobacterium tuberculosis H37Rv	888147
NP_216689.1	CDS	idsA2	NC_000962.2	2434847	2435905	D	Rv2173, (MTV021.06), len: 352 aa. Probable idsA2, geranylgeranyl pyrophosphate synthase (EC 2.5.1.-), similar to many e.g. Q54193 geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa). Contains PS00723 and PS00444Polyprenyl synthetases signature 1 and 2. FASTA scores: sptr|Q54193|Q54193 GERANYLGERANYL PYROPHOSPHATE SYNTHASE (425 aa) opt: 744, E(): 0; 39.2% identity in 352 aa overlap. TBparse score is 0.900; geranylgeranyl pyrophosphate synthetase	2434847..2435905	Mycobacterium tuberculosis H37Rv	888334
NP_216690.1	CDS	Rv2174	NC_000962.2	2435909	2437459	D	Rv2174, (MTV021.07), len: 516 aa. Possible conserved integral membrane protein, similar to some hypothetical mycobacterial proteins e.g. Mycobacterium leprae ML0899 probable integral-membrane protein (505 aa) and MLCL536_26 (593 aa). FASTA scores: ML0899 opt: 2715; 78.884% identity in 502 aa overlap and gp|Z99125|MLCL536_26 Mycobacterium leprae cosmid L536. (593 aa) opt: 552, E(): 7.1e-30; 31.6% identity in 513 aa overlap. Also similar to Rv1459c. TBparse score is 0.912; integral membrane protein	2435909..2437459	Mycobacterium tuberculosis H37Rv	887528
NP_216691.1	CDS	Rv2175c	NC_000962.2	2437446	2437886	R	Rv2175c, (MTV021.08c), len: 146 aa. Conserved hypothetical protein, possibly involved in regulation. Contains possible helix-turn-helix domain at aa 31-52 (Score 1042, +2.74 SD). Equivalent to Mycobacterium leprae ML0898 putative DNA-binding protein (134 aa). FASTA scores: opt: 747; 82.090% identity in 134 aa overlap (AL022602) >gi|13092969|emb|CAC31279.1| (AL583920); putative regulatory protein	complement(2437446..2437886)	Mycobacterium tuberculosis H37Rv	887852
NP_216692.1	CDS	pknL	NC_000962.2	2437941	2439140	D	Rv2176, (MTV021.09), len: 399 aa. Probable pknL, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), similar to many e.g. MLCB1770_9 (622 aa). Lacks C-terminal domain and ends with putative transmembrane segment. Contains PS00108 Serine/Threonine protein kinases active-site signature. FASTA scores: Z70722|MLC B1770_9 Mycobacterium leprae cosmid B1770 (622 aa) opt: 732, E(): 5.9e-23; 44.4% identity in 266 aa overlap. Also similar to several Mycobacterium tuberculosis STPK proteins e.g. Rv0014c|PKNB, Rv0015c|PKNA, Rv1743|PKNE, Rv1266c|PKNH etc. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.TBparse score is 0.921.; transmembrane serine/threonine-protein kinase L	2437941..2439140	Mycobacterium tuberculosis H37Rv	888340
NP_216693.1	CDS	Rv2177c	NC_000962.2	2439282	2439947	R	Rv2177c, (MTV021.10c), len: 221 aa. Possible IS1558 transposase (see citation below), similar to several IS element proteins and transposases but nearly identical to last 221 residues of MTCY428_23 (333 aa). FASTA scores: Z81451|MTCY428_23 Mycobacterium tuberculosis cosmid (333 aa) opt: 1491, E() : 0; 98.6% identity in 221 aa overlap. TBparse score is 0.904.; transposase	complement(2439282..2439947)	Mycobacterium tuberculosis H37Rv	888326
NP_216694.1	CDS	aroG	NC_000962.2	2440332	2441720	R	Rv2178c, (MTV021.11c), len: 462 aa. Probable aroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase similar to many, especially those from plants. FASTA scores: Y15113|M C3DDAH7P_1Morinda citrifolia mRNA for 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (535 aa) opt: 1421, E(): 0; 48.3% identity in 443 aa overlap. TBparse score is 0.903.; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG	complement(2440332..2441720)	Mycobacterium tuberculosis H37Rv	888309
NP_216695.1	CDS	Rv2179c	NC_000962.2	2441811	2442317	R	Rv2179c, (MTV021.12c), len: 168 aa. Conserved hypothetical protein, equivalent to conserved hypothetical protein from Mycobacterium leprae ML0895 conserved hypothetical protein (171 aa). FASTA scores: opt: 977, E(): 1.4e-58; 82.530% identity in 166 aa overlap (AL022602). TBparse score is 0.912; hypothetical protein	complement(2441811..2442317)	Mycobacterium tuberculosis H37Rv	887927
NP_216696.1	CDS	Rv2180c	NC_000962.2	2442327	2443214	R	Rv2180c, (MTV021.13c), len: 295 aa. Probable conserved integral membrane protein, similar to pir||T35292 probable integral membrane protein from Streptomyces coelicolor >gi|5578858|emb|CAB51260.1| (AL096872) (246 aa) (36% identity in 249 aa overlap). TBparse score is 0.914; integral membrane protein	complement(2442327..2443214)	Mycobacterium tuberculosis H37Rv	887954
NP_216697.1	CDS	Rv2181	NC_000962.2	2443302	2444585	D	Rv2181, (MTV021.14), len: 427 aa. Probable conserved integral membrane protein, similar to others in Mycobacterium tuberculosis e.g. Rv1159 (MTCI65.26, 431 aa). Start uncertain. FASTA scores: Z95584|MTCI65_26 (431 aa) opt: 428, E(): 8e-22; 31.2% identity in 407 aa overlap. TBparse score is 0.921; integral membrane protein	2443302..2444585	Mycobacterium tuberculosis H37Rv	888269
NP_216698.1	CDS	Rv2182c	NC_000962.2	2444586	2445329	R	Rv2182c, (MTV021.15c), len: 247 aa. Probable 1-acylglycerol-3-phosphate O-acyltransferase, similar to many e.g. in Streptomyces. Contains PS00017 ATP/GTP-binding site motif A (P-loop). FASTA scores: pir||T35503 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) homolog SC6E10.16c - Streptomyces coelicolor >gi|5689932|emb|CAB51970.1| (AL109661) hypothetical protein [Streptomyces coelicolor A3(2)] Length = 262, Expect = 6e-61 (54% identity in 215 aa overlap). TBparse score is 0.926; 1-acylglycerol-3-phosphate O-acyltransferase	complement(2444586..2445329)	Mycobacterium tuberculosis H37Rv	888625
NP_216699.1	CDS	Rv2183c	NC_000962.2	2445415	2445810	R	Rv2183c, (MTV021.16c), len: 131 aa. Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical protein ML0891 (MLCB268.25c, 130 aa). FASTA scores: opt: 558, E(): 8.3e-28; 61.832% identity in 131 aa overlap >gi|13092963|emb|CAC31272.1| (AL583920) (AL022602). TBparse score is 0.895; hypothetical protein	complement(2445415..2445810)	Mycobacterium tuberculosis H37Rv	887650
NP_216700.1	CDS	Rv2184c	NC_000962.2	2445807	2446946	R	Rv2184c, (MTV021.17c), len: 379 aa. Conserved hypothetical protein, equivalent to hypothetical protein ML0890 (415 aa) from Mycobacterium leprae and also shows some similarity to other hypothetical proteins. FASTA scores: ML0890 opt: 1949; 79.630% identity in 378 aa overlap >emb|CAA18692.1| (AL022602) >gi|13092962|emb|CAC31271.1| (AL583920) and sptr|Q55794|Q55794 HYPOTHETICAL 44.6 kDa PROTEIN. (396 aa) opt: 251, E(): 3.3e-09; 25.5% identity in 384 aa overlap. TBparse score is 0.920; hypothetical protein	complement(2445807..2446946)	Mycobacterium tuberculosis H37Rv	888152
NP_216701.1	CDS	TB16.3	NC_000962.2	2447066	2447500	R	Rv2185c, (MTV021.18c), len: 144 aa. TB16.3, conserved hypothetical protein, similar to other hypothetical actinomycete proteins and equivalent to Mycobacterium leprae ML0889 (144 aa). Some similarity to Mycobacterium tuberculosis Rv0854, Rv0856, Rv0857, Rv0164 and other Mycobacterium leprae proteins. FASTA scores : ML0889 opt: 811; 85.417% identity in 144 aa overlap (AL022602). TBparse score is 0.927.; hypothetical protein	complement(2447066..2447500)	Mycobacterium tuberculosis H37Rv	887239
NP_216702.1	CDS	Rv2186c	NC_000962.2	2447605	2447994	R	Rv2186c, (MTV021.19c), len: 129 aa. Conserved hypothetical protein, equivalent to hypothetical Mycobacterium leprae protein ML0888 (135 aa). FASTA scores: ML0888 opt: 704, E(): 2.9e-43; 80.000% identity in 130 aa overlap CAA18694.1| (AL022602). TBparse score is 0.927; hypothetical protein	complement(2447605..2447994)	Mycobacterium tuberculosis H37Rv	887347
NP_216703.1	CDS	fadD15	NC_000962.2	2448160	2449962	D	Rv2187, (MTV021.20), len: 600 aa. Probable fadD15, long-chain-fatty-acid-CoA ligase (EC 6.2.1.3), similar to several e.g. P44446|LCFH_HAEIN PUTATIVE LONG-CHAIN-FATTY-ACID--CoA LIGASE from Haemophilus influenzae (607 aa), FASTA scores: (607 aa) opt: 992, E(): 0, (31.5% identity in 578 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. TBparse score is 0.902.; long-chain-fatty-acid-CoA ligase fadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	2448160..2449962	Mycobacterium tuberculosis H37Rv	887456
NP_216704.2	CDS	Rv2188c	NC_000962.2	2449993	2451150	R	Rv2188c, (MTV021.21c), len: 385 aa. Conserved hypothetical protein, possibly glycosyl transferase similar to several putative glycosyl transferases and hypothetical proteins e.g. P73369. Equivalent to Mycobacterium leprae ML0886 putative glycosyl transferase (384 aa). FASTA scores: ML0886 (CAA18697.1| (AL022602) ) opt: 2113, E(): 1.8e-106; 81.462% identity in 383 aa overlap; sptr|P73369|P73369 HYPOTHETICAL 46.2 kDa PROTEIN (404 aa) opt: 379, E(): 2.2e-18; 27.5% identity in 397 aa overlap. Start changed since first submission, now 14 aa shorter. TBparse score is 0.913; hypothetical protein	complement(2449993..2451150)	Mycobacterium tuberculosis H37Rv	887278
NP_216705.1	CDS	Rv2189c	NC_000962.2	2451247	2452020	R	Rv2189c, (MTV021.22c), len: 257 aa. Conserved hypothetical protein; some similarity to hypothetical protein SC6G10.07c (385 aa) from Streptomyces coelicolor A3(2). Smith-Waterman scores: pir||T35516 hypothetical protein SC6G10.07c - Streptomyces coelicolor >gi|4539203|emb|CAB39861.1| (AL049497) Expect = 2e-08; 30% identity in 245 aa overlap. TBparse score is 0.908; hypothetical protein	complement(2451247..2452020)	Mycobacterium tuberculosis H37Rv	887575
NP_216706.1	CDS	Rv2190c	NC_000962.2	2452115	2453272	R	Rv2190c, (MTV021.23c, MTCY190.01c), len: 385 aa. Conserved hypothetical protein; similar to other hypothetical mycobacterial proteins, including Rv1477, Rv1478, Rv1566c, Rv0024, that are similar to protein p60 precursors from Listeria e.g. Q018 38|P60_LISSE protein p60 precursor (invasion-associated protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25 (281 aa) opt: 290, E(): 6.9e-05; 37.0% identity in 127 aa overlap and sp|Q01838|P60_LISSE PROTEIN P60 PRECURSOR (523 aa) opt: 268, E(): 0.00071; 38.5% identity in 104 aa overlap. TBparse score is 0.927; hypothetical protein	complement(2452115..2453272)	Mycobacterium tuberculosis H37Rv	888670
NP_216707.1	CDS	Rv2191	NC_000962.2	2453819	2455756	D	contains 3'-5'exonuclease domain; hypothetical protein	2453819..2455756	Mycobacterium tuberculosis H37Rv	887265
NP_216708.1	CDS	trpD	NC_000962.2	2455631	2456743	R	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase	complement(2455631..2456743)	Mycobacterium tuberculosis H37Rv	887681
NP_216709.1	CDS	ctaE	NC_000962.2	2456901	2457512	D	Rv2193, (MTCY190.04), len: 203 aa. Probable ctaE, cytochrome c oxidase polypeptide III (cox3) (EC 1.9.3.1), with strong similarity to others e.g. COX3_SYNY3|Q06475 (29.8% identity in 225 aa overlap).; cytochrome C oxidase subunit III	2456901..2457512	Mycobacterium tuberculosis H37Rv	887425
NP_216710.1	CDS	qcrC	NC_000962.2	2457553	2458395	D	Rv2194, (MTCY190.05), len: 280 aa. Probable qcrC, Ubiquinol-cytochrome C reductase cytochrome C subunit (cyoA), shows similarity to cytochrome c family; contains 2 X PS00190 Cytochrome c family heme-binding site signature.; ubiquinol-cytochrome C reductase QcrC(cytochrome C subunit)	2457553..2458395	Mycobacterium tuberculosis H37Rv	888737
NP_216711.1	CDS	qcrA	NC_000962.2	2458392	2459681	D	Rv2195, (MTCY190.06), len: 429 aa. Probable qcrA, Ubiquinol-cytochrome C reductase iron-sulfur subunit (cyoB), shows some similarity to cytochrome B6-F complex iron-sulphur subunits (Rieske iron-sulfur protein); contains PS00200 Rieske iron-sulfur protein signature 2; Rieske iron-sulfur protein QcrA	2458392..2459681	Mycobacterium tuberculosis H37Rv	888420
NP_216712.1	CDS	qcrB	NC_000962.2	2459678	2461327	D	Rv2196, (MTCY190.07), len: 549 aa. Probable qcrB, Ubiquinol-cytochrome C reductase cytochrome B subunit (cytB), integral membrane protein, low similarity in amino-terminal half to cytochrome b subunits, highly similar at C-terminus to SW:12KD_MYCLE P15878 12 KD protein PIR:S08427 (86.9% identity in 153 aa overlap). FASTA scores: sp|Q45658|QCRB_BACST MENAQUINOL-CYTOCHROME C REDUCTASE (224 aa) opt: 341, E(): 6.8e-15; 28.0% identity in 207 aa overlap; ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit)	2459678..2461327	Mycobacterium tuberculosis H37Rv	887400
NP_216713.1	CDS	Rv2197c	NC_000962.2	2461504	2462148	R	Rv2197c, (MTCY190.08c), len: 214 aa. Probable conserved transmembrane protein, equivalent to ML0878 conserved hypothetical protein (212 aa) of Mycobacterium leprae. FASTA scores: opt: 858; 62.559% identity in 211 aa overlap CAC31259.1|(AL583920); transmembrane protein	complement(2461504..2462148)	Mycobacterium tuberculosis H37Rv	887213
NP_216714.1	CDS	mmpS3	NC_000962.2	2462148	2463047	R	Rv2198c, (MTCY190.09c), len: 301 aa. Probable mmpS3, conserved membrane protein (see citation below), equivalent to ML0877|mmpS3 putative membrane protein from Mycobacterium leprae (293 aa), FASTA scores: opt: 1089, E(): 1.2e-43, (69.80% identity in 308 aa overlap). Also similar to other proteins e.g. Rv3209 from Mycobacterium tuberculosis. Contains PS00499 C2 domain signature, a hydrophobic region, and a repetitive proline and threonine rich region. BELONGS TO THE MMPS FAMILY.; membrane protein	complement(2462148..2463047)	Mycobacterium tuberculosis H37Rv	887471
NP_216715.1	CDS	Rv2199c	NC_000962.2	2463233	2463652	R	Rv2199c, (MTCY190.10c), len: 139 aa. Possible conserved integral membrane protein, similar to hypothetical membrane proteins in Actinomycetes and equivalent to Mycobacterium leprae, ML0876, putative membrane protein (139 aa) FASTA scores: opt: 866, E(): 1.1e-43; 91.367% identity in 139 aa overlap CAC31257.1| (AL583920); integral membrane protein	complement(2463233..2463652)	Mycobacterium tuberculosis H37Rv	888692
NP_216716.1	CDS	ctaC	NC_000962.2	2463660	2464751	R	Rv2200c, (MTCY190.11c), len: 363 aa. Probable ctaC, transmembrane cytochrome C oxidase (subunit II), COX2, similar e.g. to JT0964 cytochrome-c oxidase chain II (23.0% identity in 317 aa overlap); etc. Contains PS00078 Cytochrome c oxidase subunit II, copper A binding region signature. BELONGS TO THE CYTOCHROME C OXIDASE SUBUNIT 2 FAMILY.; transmembrane cytochrome C oxidase subunit II CtaC	complement(2463660..2464751)	Mycobacterium tuberculosis H37Rv	888799
NP_216717.1	CDS	asnB	NC_000962.2	2464997	2466955	D	Rv2201, (MTCY190.12), len: 652 aa. Probable asnB, asparagine synthetase, similar to e.g. SW:ASNH_BACSU P42113 putative asparagine synthetase (26.0% identity in 438 aa overlap); asparagine synthetase AsnB	2464997..2466955	Mycobacterium tuberculosis H37Rv	888472
NP_216718.1	CDS	cbhK	NC_000962.2	2467053	2468027	R	Rv2202c, (MTCY190.13c), len: 324 aa. Probable cbhK, carbohydrate kinase (but not ribose) (EC 2.7.-.-), similar to several e.g. AE000915_1 Methanobacterium thermoautotrop (309 aa) FASTA score: opt: 370, E(): 3.3e-18; 31.2% identity in 276 aa overlap. Low similarity to carbohydrate kinases, e.g. SW:RBSK_BACSU P36945 ribokinase (23.9% identity in 272 aa overlap); contains PS00583 pfkB family of carbohydrate kinases signature 1; carbohydrate kinase CbhK	complement(2467053..2468027)	Mycobacterium tuberculosis H37Rv	888551
NP_216719.1	CDS	Rv2203	NC_000962.2	2468231	2468923	D	Rv2203, (MTCY190.14), len: 230 aa. Possible conserved membrane protein; has single hydrophobic stretch from aa 75 to 97 and is equivalent to Mycobacterium leprae ML0872 putative membrane protein (171 aa). FASTA scores: opt: 821, E(): 3.4e-42; 72.353% identity in 170 aa overlap - CAC31253.1| (AL583920). 2468411.; hypothetical protein	2468231..2468923	Mycobacterium tuberculosis H37Rv	888318
NP_216720.1	CDS	Rv2204c	NC_000962.2	2468931	2469287	R	Rv2204c, (MTCY190.15c), len: 118 aa. Conserved hypothetical protein. Similar to conserved hypothetical proteins in Actinomycetes and equivalent to Mycobacterium leprae ML0871|ML0871 conserved hypothetical protein (118 aa) and to sp|P45344|YADR_HAEIN HYPOTHETICAL PROTEIN HI1723 (114 aa). FASTA score: ML0871 opt: 720, E(): 8.4e-45; 92.373% identity in 118 aa overlapCAC31252.1| (AL583920); and P45344 opt: 346, E(): 1.8e-18; 45.6% identity in 103 aa overlap. Contains PS01152 Hypothetical hesB/y yadR/yfhF family signature; hypothetical protein	complement(2468931..2469287)	Mycobacterium tuberculosis H37Rv	888428
NP_216721.2	CDS	Rv2205c	NC_000962.2	2469387	2470463	R	Rv2205c, (MTCY190.16c), len: 358 aa. Conserved hypothetical protein. Very similar to YHAD_ECOLI|P23524 hypothetical protein (YHAD (E.coli) / YXAA (S14A) (B.subtilis) family) (41.6% identity in 154 aa overlap), and to other members of the glycerate kinase family. Start changed since first submission; protein now 122 aa shorter, owing to extension of Rv2206.; hypothetical protein	complement(2469387..2470463)	Mycobacterium tuberculosis H37Rv	887277
NP_216722.2	CDS	Rv2206	NC_000962.2	2470622	2471332	D	Rv2206, (MTCY190.17), len: 236 aa. Probable conserved transmembrane protein. Equivalent to hypothetical protein ML0869 (247 aa) of Mycobacterium leprae gZ98741|MLCB22_2 (247 aa), FASTA scores: opt: 1052, (67.5% identity in 237 aa overlap). Two hydrophobic stretches in C-terminal part. Start changed since original submission (+112 aa).; transmembrane protein	2470622..2471332	Mycobacterium tuberculosis H37Rv	888107
NP_216723.1	CDS	cobT	NC_000962.2	2471411	2472496	D	catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	2471411..2472496	Mycobacterium tuberculosis H37Rv	887781
NP_216724.1	CDS	cobS	NC_000962.2	2472493	2473242	D	catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase	2472493..2473242	Mycobacterium tuberculosis H37Rv	887572
NP_216725.1	CDS	Rv2209	NC_000962.2	2473400	2474938	D	Rv2209, (MTCY190.20), len: 512 aa. Probable conserved integral membrane protein, similar to but longer than Rv0246 gp|AL021929|MTV 034_12 Mycobacterium tuberculosis (436 aa). FASTA score: opt: 712, E(): 2.8e- 32; 33.4% identity in 422 aa overlap; integral membrane protein	2473400..2474938	Mycobacterium tuberculosis H37Rv	887230
NP_216726.1	CDS	ilvE	NC_000962.2	2474864	2475970	R	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase	complement(2474864..2475970)	Mycobacterium tuberculosis H37Rv	888352
NP_216727.1	CDS	gcvT	NC_000962.2	2476042	2477181	R	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T	complement(2476042..2477181)	Mycobacterium tuberculosis H37Rv	887233
NP_216728.1	CDS	Rv2212	NC_000962.2	2477190	2478326	D	Rv2212, (MTCY190.23), len: 378 aa. Conserved hypothetical protein. Some similarity to adenylate cyclases, e.g. SW:CYAA_STRCO P40135 (29.2% identity in 291 aa overlap); ttg at 24614 in MTCY190 has a better rbs. Contains possible helix-turn-helix motif at aa 64- 85, (+2.72 SD). Also similar to Rv1264 and Rv1647; hypothetical protein	2477190..2478326	Mycobacterium tuberculosis H37Rv	887979
NP_216729.1	CDS	pepB	NC_000962.2	2478338	2479885	D	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase	2478338..2479885	Mycobacterium tuberculosis H37Rv	888105
NP_216730.1	CDS	ephD	NC_000962.2	2479923	2481701	R	Rv2214c, (MTCY190.25c), len: 592 aa. Possible ephD, short-chain dehydrogenase (EC 1.-.-.-) (see citation below), equivalent to Z98741|MLCB22_8 Mycobacterium leprae cosmid B22; (596 aa), FASTA score: opt: 3262, E(): 0; 80.4% identity in 596 aa overlap. C-terminus similar to short-chain alcohol dehydrogenase family, similar to SW:LIGD_PSEPA Q01198 c alpha-dehydrogenase (30.7% identity in 241 aa overlap); contains PS00061 Short-chain alcohol dehydrogenase family signature, PS00697 ATP-dependent DNA ligase AMP-binding site. N-terminus corresponds to several epoxide hydrolases of plants and Mycobacterium tuberculosis e.g. MTCY9F925; short chain dehydrogenase	complement(2479923..2481701)	Mycobacterium tuberculosis H37Rv	887472
NP_216731.1	CDS	dlaT	NC_000962.2	2481965	2483626	D	E2 component; part of pyruvate dehydrogenase; forms a complex with AceA and LpdC; dihydrolipoamide acetyltransferase	2481965..2483626	Mycobacterium tuberculosis H37Rv	888777
NP_216732.1	CDS	Rv2216	NC_000962.2	2483626	2484531	D	Rv2216, (MTCY190.27), len: 301 aa. Conserved hypothetical protein, equivalent to Mycobacterium leprae ML0860 (307 aa), Z98741|MLCB22_10 Mycobacterium leprae cosmid B22; H (307 aa). FASTA score: opt: 1656, E(): 0; 84.2% identity in 297 aa overlap. Also gp|AE000319|ECAE000319_8 Escherichia coli strain K12 MG1655 (297 aa) opt: 640, E(): 0; 39.5% identity in 294 aa overlap.; hypothetical protein	2483626..2484531	Mycobacterium tuberculosis H37Rv	887640
NP_216733.1	CDS	lipB	NC_000962.2	2484584	2485276	D	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B	2484584..2485276	Mycobacterium tuberculosis H37Rv	887626
NP_216734.1	CDS	lipA	NC_000962.2	2485273	2486208	D	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase	2485273..2486208	Mycobacterium tuberculosis H37Rv	887922
NP_216735.1	CDS	Rv2219	NC_000962.2	2486235	2486987	D	Rv2219, (MTCY190.30), len: 250 aa. Probable conserved transmembrane protein. Equivalent to hypothetical membrane protein ML0857 (250 aa) from Mycobacterium leprae Z98741 |MLCB22_13 Mycobacterium leprae cosmid B22; H (250 aa) opt : 1328, E(): 0; 80.8% identity in 250 aa overlap.; transmembrane protein	2486235..2486987	Mycobacterium tuberculosis H37Rv	888380
YP_177661.1	CDS	Rv2219A	NC_000962.2	2486994	2487416	R	Rv2219A, len: 140 aa. Probable conserved membrane protein, similar to SC3H12.05c|AL355740_5 possible integral membrane protein from Streptomyces coelicolor (155 aa), FASTA scores: opt: 327, E(): 7.5e-14, (46.6% identity in 133 aa overlap), also linked to glnA.; hypothetical protein	complement(2486994..2487416)	Mycobacterium tuberculosis H37Rv	3205099
NP_216736.1	CDS	glnA1	NC_000962.2	2487615	2489051	D	Rv2220, (MTCY190.31, MTCY427.01), len: 478 aa. glnA1, glutamine synthetase class I (EC 6.3.1.2) (see Tullius et al., 2001), similar to many e.g. GLNA_STRCO|P15106 from Streptomyces coelicolor, FASTA score: (71.4% identity in 475 aa overlap); etc. Also similar to three other potential glutamine synthetases in Mycobacterium tuberculosis: Rv2222c|glnA2, Rv2860c|glnA4, and Rv1878|glnA3. Contains PS00180 Glutamine synthetase signature 1, PS00181 Glutamine synthetase putative ATP-binding region signature, and PS00182 Glutamine synthetase class-I adenylation site. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY.; glnA; glutamine synthetase GLNA1 (glutamine synthase) (GS-I)	2487615..2489051	Mycobacterium tuberculosis H37Rv	888383
NP_216737.1	CDS	glnE	NC_000962.2	2489369	2492353	R	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase	complement(2489369..2492353)	Mycobacterium tuberculosis H37Rv	887995
NP_216738.1	CDS	glnA2	NC_000962.2	2492402	2493742	R	Rv2222c, (MTCY427.03c), len: 446 aa. Probable glnA2, glutamine synthetase class II (EC 6.3.1.2), similar to others. Also similar to three other potential glutamine synthetases in Mycobacterium tuberculosis: Rv2220|glnA1, Rv2860c|glnA4, and Rv1878|glnA3. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY.; glutamine synthetase	complement(2492402..2493742)	Mycobacterium tuberculosis H37Rv	888238
NP_216739.1	CDS	Rv2223c	NC_000962.2	2493837	2495399	R	Rv2223c, (MTCY427.04c), len: 520 aa. Probable exported protease (EC 3.4.-.-); has signal sequence. Very similar to three proteases/peptidases from Streptomyces spp.: L42758, L42759, L27466. FASTA score: L42758|STMSLPD STMSLPD NID: g940302 - Streptomyces (539 aa) opt: 1032 E(): 0, (37.5% identity in 533 aa overlap). Also similar to hypothetical proteins YZZE _ECOLI|P34211 from Escherichia coli (25.4% identity in 406 aa overlap) and PIR:B36944 in ompP 3' region (27.5% identity in 218 aa overlap). Highly similar to Rv2224c and Rv2672 (49.3% identity in 507 aa overlap); contains PS00120 Lipases, serine active site; exported protease	complement(2493837..2495399)	Mycobacterium tuberculosis H37Rv	888093
NP_216740.1	CDS	Rv2224c	NC_000962.2	2495461	2497023	R	Rv2224c, (MTCY427.05c), len: 520 aa. Probable exported protease (EC 3.4.-.-); has signal sequence and lipoprotein motif at N-terminal end. Very similar to three proteases/peptidases from Streptomyces spp.: L42758, L42759, L27466. FASTA score: L4 2758|STMSLPD STMSLPD NID: g940302 - Streptomyces (539 aa) opt: 1032 E(): 0, (37.5% identity in 533 aa overlap). Similar to hypothetical protein SW:YZZE_ECOLI P34211 (27.7% identity in 412 aa overlap) and highly similar to Rv2224c and Rv2672 (49.3% identity in 507 aa overlap); contains PS00013, Prokaryotic membrane lipoprotein lipid attachment site, and PS00120 Lipases, serine active site.; exported protease	complement(2495461..2497023)	Mycobacterium tuberculosis H37Rv	887857
NP_216741.1	CDS	panB	NC_000962.2	2497742	2498587	D	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase	2497742..2498587	Mycobacterium tuberculosis H37Rv	887440
NP_216742.1	CDS	Rv2226	NC_000962.2	2498832	2500373	D	Rv2226, (MTCY427.07), len: 513 aa. Conserved hypothetical protein, similar to hypothetical secreted protein (510 aa) from Streptomyces coelicolor A3(2) emb|CAB59601.1| (AL132662) hypothetical secreted protein [Streptomyces coelicolor. Smith-Waterman scores Expect = 5e-44 Identities = 166/506 (32%); hypothetical protein	2498832..2500373	Mycobacterium tuberculosis H37Rv	888513
NP_216743.1	CDS	Rv2227	NC_000962.2	2500931	2501632	D	Rv2227, (MTCY427.08), len: 233 aa. Conserved hypothetical protein, similar to conserved hypothetical proteins from various bacteria e.g. gb|AAK22693.1| (AE005746) conserved hypothetical protein from Caulobacter crescentus (234 aa) Smith-Waterman score = 109 bits (429), Expect = 1e-41 Identities = 83/167 (49%); hypothetical protein	2500931..2501632	Mycobacterium tuberculosis H37Rv	888581
NP_216744.1	CDS	Rv2228c	NC_000962.2	2501644	2502738	R	Rv2228c, (MTCY427.09c), len: 364 aa. Conserved hypothetical protein. Some similarity to phosphoglycerate mutase and ribonuclease H. Similar to CAB88177.1|AL352972 putative bifunctional protein (ribonuclease H/phosphoglycerate mutase) from Streptomyces coelicolor A3(2) (497 aa); Smith-Waterman scores: 107 bits (424), Expect = 4e-41 Identities = 160/485 (32%). Also similar in C-terminal part to Rv2419c and Rv2135c.; bifunctional RNase H/acid phosphatase	complement(2501644..2502738)	Mycobacterium tuberculosis H37Rv	888108
NP_216745.1	CDS	Rv2229c	NC_000962.2	2502735	2503472	R	Rv2229c, (MTCY427.10c), len: 245 aa. Conserved hypothetical protein; probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium leprae ML1638 (232 aa), FASTA scores: opt: 868 E(): 4.4e-43; 60.870% identity in 230 aa overlap emb|CAC30589.1| (AL583922); hypothetical protein	complement(2502735..2503472)	Mycobacterium tuberculosis H37Rv	888264
NP_216746.1	CDS	Rv2230c	NC_000962.2	2503469	2504608	R	Rv2230c, (MTCY427.11c), len: 379 aa. Conserved hypothetical protein. Equivalent to Mycobacterium leprae, ML1639, conserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis, P54472, and L. monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU HYPOTHETICAL 30. 7 kDa PROTEIN IN (279 aa) opt: 604; E(): 2.2e-30; 38.8% identity in 258 aa overlap. P53434|YRP2_LISMO HYPOTHETICAL 41.4 kDa PROTEIN (373 aa) opt: 595, E(): 1e-29; 30.7% identity in 326 aa overlap; hypothetical protein	complement(2503469..2504608)	Mycobacterium tuberculosis H37Rv	888231
NP_216747.1	CDS	cobC	NC_000962.2	2504605	2505699	R	Rv2231c, (MTCY427.12c), len: 364 aa. Possible cobC, aminotransferase. Note that initiation codon uncertain. Similar to CobC aminotransferases e.g. sp|P21633|COBC_PSEDE COBC PROTEIN (333 aa) opt: 277, E(): 1.7e-11; 28.8% identity in 313 aa overlap and also to e.g. SW:HIS8_ECOLI P06986 histidinol-phosphate aminotransferase (27.0% identity in 289 aa overlap), contains PS00105 aminotransferases class-I pyridoxal-phosphate attachment site. Real Mycobacterium tuberculosis histidinol-phosphate aminotransferase, hisC, is Rv1600 (MTCY336.04c).; hypothetical protein	complement(2504605..2505699)	Mycobacterium tuberculosis H37Rv	888337
NP_216748.2	CDS	Rv2232	NC_000962.2	2506278	2507153	D	Rv2232, (MTCY427.13), len: 291 aa. Conserved hypothetical protein, similar to members of haloacid dehalogenase-like family from several bacteria and to putative phosphatases e.g. Q9I767 and AAK78398. Contains N-terminal extension. FASTA scores: Q9I767 HYPOTHETICAL PROTEIN PA0065 (221 aa) opt: 439 E(): 3.2e-18; 38.679% identity (40.196% ungapped) in 212 aa overlap; >>tr|AAK78398 Predicted phosphatase, HAD family (216 aa) opt: 427, E(): 1.5e-17; 34.762% identity (35.437% ungapped) in 210 aa overlap. Replaces previous Rv2232 and Rv2233.; hypothetical protein	2506278..2507153	Mycobacterium tuberculosis H37Rv	887597
NP_216750.1	CDS	ptpA	NC_000962.2	2507146	2507637	D	Rv2234, (MTCY427.15), len: 163 aa. ptpA (alternate gene name: MPtpA), low molecular weight protein-tyrosine-phosphatase (see citations below) (EC 3.1.3.48), similar to other phosphotyrosine protein phosphatases e.g. P53433|PTPA_STRCO LOW MOLECULAR WEIGHT PROTEIN-TYROSINE PHOSPHATASE from Streptomyces coelicolor (164 aa), FASTA scores: opt: 455, E(): 3.3e -25, (49.7% identity in 155 aa overlap); PA1S_HUMAN|P24667 red cell acid phosphatase 1, FASTA score: (37.7% identity in 138 aa overlap); etc. Contains a phosphatase catalytic site domain located in N-terminal part. Activity proven biochemically. Supposed a secreted protein.; MPtpA; phosphotyrosine protein phosphatase PTPA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	2507146..2507637	Mycobacterium tuberculosis H37Rv	887373
NP_216751.1	CDS	Rv2235	NC_000962.2	2507637	2508452	D	Rv2235, (MTCY427.16), len: 271 aa. Probable conserved transmembrane protein (see Miller & Shinnick 2001); hydrophobic regions near N- and C-terminus. Similar to conserved membrane proteins in other Actinomycetes. Equivalent to Mycobacterium leprae. ML1644 (270 aa). FASTA scores: opt: 1357, E(): 1.2e-72; 74.170% identity in 271 aa overlap T44717|3150235|CAA19213.1|AL023635 13093419|CAC30595.1|AL583922.; transmembrane protein	2507637..2508452	Mycobacterium tuberculosis H37Rv	887606
NP_216752.1	CDS	cobD	NC_000962.2	2508434	2509375	R	CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; cobalamin biosynthesis protein	complement(2508434..2509375)	Mycobacterium tuberculosis H37Rv	887513
NP_216753.1	CDS	Rv2237	NC_000962.2	2509489	2510256	D	Rv2237, (MTCY427.18), len: 255 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical proteins Rv0276, Rv0826, Rv1645c. FASTA score: Rv0276 gp|AL021930|MTV035_4 (306 aa) opt: 874, E(): 0; 49.6% identity in 282 aa overlap; hypothetical protein	2509489..2510256	Mycobacterium tuberculosis H37Rv	887840
NP_216754.1	CDS	ahpE	NC_000962.2	2510715	2511176	R	Rv2238c, (MTCY427.19c), len: 153 aa. Probable ahpE, peroxiredoxin. Similarity to many members of AHPC/TSA family e.g. sp|Q96291|BAS1_ARATH 2-CYS PEROXIREDOXIN BAS1 PRECURSOR (265 aa). FASTA score: opt: 275, E(): 2.7e-12; 35.0% identity in 143 aa overlap.; peroxiredoxin AhpE	complement(2510715..2511176)	Mycobacterium tuberculosis H37Rv	887871
NP_216755.1	CDS	Rv2239c	NC_000962.2	2511176	2511652	R	Rv2239c, (MTCY427.20c), len: 158 aa. Conserved hypothetical protein, similar to conserved hypothetical proteins from Mycobacterium leprae (ML1649, 140 aa) and Streptomyces coelicolor A3(2) (SCC8A.28c, 159 aa). Equivalent to ML1649 conserved hypothetical protein (140 aa). FASTA scores: ML1649 conserved hypothetical protein (140 aa) opt: 846, E(): 6.5e-45; 86.429% identity in 140 aa overlap (tr|O69479|O69479 HYPOTHETICAL 15.2 KDA PROTEIN (140 aa); and opt: 447, E(): 1.2e-21; 50.355% identity (51.825% ungapped) in 141 aa overlap. Similarity with ML1649 suggests alternative start at 251198.; hypothetical protein	complement(2511176..2511652)	Mycobacterium tuberculosis H37Rv	888451
NP_216756.1	CDS	Rv2240c	NC_000962.2	2511690	2512487	R	Rv2240c, (MTCY427.21c), len: 265 aa. Hypothetical unknown protein.; hypothetical protein	complement(2511690..2512487)	Mycobacterium tuberculosis H37Rv	888600
NP_216757.1	CDS	aceE	NC_000962.2	2512539	2515244	D	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1	2512539..2515244	Mycobacterium tuberculosis H37Rv	887246
NP_216758.1	CDS	Rv2242	NC_000962.2	2515304	2516548	D	Rv2242, (MTCY427.23), len: 414 aa. Conserved hypothetical protein. Equivalent to ML1652 conserved hypothetical protein from Mycobacterium leprae (414 aa), and orthologue in Streptomyces coelicolor A3(2). FASTA scores: ML1652 opt: 2369, E(): 4.2e-128; 88.406% identity in 414 aa overlap (AL023635)(AL583922). some similarity at 3' end with S25203 srmR protein - Streptomyces ambofaciens (604 aa) opt: 188 E(): 9e-05; (26.4% identity in 277 aa overlap) and with SW:YAEG_HAEIN P44509 hypothetical protein HI0093 (42.3% identity in 52 aa overlap). Contains possible helix-turn-helix motif at aa 360-381 (+3.52 SD); hypothetical protein	2515304..2516548	Mycobacterium tuberculosis H37Rv	888624
NP_216759.1	CDS	fabD	NC_000962.2	2516787	2517695	D	Rv2243, (MTCY427.24), len: 302 aa. fabD (alternate gene name: mtFabD), malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (see citations below), highly similar to e.g. A57356 acyl-CoA carrier protein malonyltransferase from Streptomyces coelicolor (316 aa), FASTA score: opt: 955, E(): 0, (52.6% identity in 304 aa overlap); FABD_HAEIN|P43712 malonyl CoA-acyl carrier protein transacylase from Haemophilus influenzae, FASTA score: (30.5% identity in 308 aa overlap); and FABD_ECOLI|P25715 from Escherichia coli, FASTA score: (31.4% identity in 309 aa overlap).; mtFabD; acyl-carrier-protein S-malonyltransferase	2516787..2517695	Mycobacterium tuberculosis H37Rv	888769
NP_216760.1	CDS	acpP	NC_000962.2	2517771	2518118	D	carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein	2517771..2518118	Mycobacterium tuberculosis H37Rv	888272
NP_216761.1	CDS	kasA	NC_000962.2	2518115	2519365	D	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II	2518115..2519365	Mycobacterium tuberculosis H37Rv	887269
NP_216762.1	CDS	kasB	NC_000962.2	2519396	2520712	D	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II	2519396..2520712	Mycobacterium tuberculosis H37Rv	887539
NP_216763.1	CDS	accD6	NC_000962.2	2520743	2522164	D	Rv2247, (MTCY427.28), len: 473 aa. accD6, Acetyl/Propionyl CoA Carboxylase, beta subunit (EC 6.4.1.3) (see citations below), highly similar to e.g. PCCB_RHOSO|Q06101 propionyl-CoA carboxylase beta chain, FASTA score: (75.1% identity in 437 aa overlap). Similar to many other Acetyl/Propionyl CoA Carboxylases from Mycobacterium tuberculosis. BELONGS TO THE ACCD / PCCB FAMILY.; acetyl/propionyl-CoA carboxylase beta subunit AccD6	2520743..2522164	Mycobacterium tuberculosis H37Rv	887671
NP_216764.1	CDS	Rv2248	NC_000962.2	2522360	2523175	D	Rv2248, (MTCY427.29), len: 271 aa. Conserved hypothetical protein. Very similar to hypothetical M. tuberculosis proteins Rv3517, Rv1482c, Rv3555c, Rv3714c, Rv1073. FASTA score: MTCY06G11.02c MTCY6G11 NID: g1877284 - (289 aa) opt: 366 E(): 5.3e-18; (32.1% identity in 249 aa overlap). Some similarity to Mycobacterium avium protein AF002133|AF0021 339 AF002133 NID: g2183254 (346 aa) opt: 308 E(): 5.2e-14; (28.3% identity in 254 aa overlap); hypothetical protein	2522360..2523175	Mycobacterium tuberculosis H37Rv	888603
NP_216765.1	CDS	glpD1	NC_000962.2	2523241	2524791	R	Rv2249c, (MTCY427.31c), len: 516 aa. Probable glpD1, glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), similar to SW:GLPD_ECOLI P13035 aerobic glycerol-3-phosphate dehydrogenase (30.0% identity in 486 aa overlap) and SW:GLPA_ECOLI P13032 anaerobic glycerol-3-phosphate dehydrogenase (28.2% identity in 504 aa overlap). Also similar to Rv3302c|glpD2 glycerol-3-phosphate dehydrogenase. COFACTOR: FAD (BY SIMILARITY). BELONGS TO THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY.; glycerol-3-phosphate dehydrogenase	complement(2523241..2524791)	Mycobacterium tuberculosis H37Rv	887276
NP_216766.2	CDS	Rv2250c	NC_000962.2	2524785	2525354	R	Rv2250c, (MTCY427.32c), len: 189 aa. Possible transcriptional regulatory protein, TetR family. Start unclear; ORF has been shortened since first submission to avoid overlap with Rv2251 (-30 aa). Contains probable helix-turn-helix motif (Score 2243, +6.70 SD); transcriptional regulator	complement(2524785..2525354)	Mycobacterium tuberculosis H37Rv	888018
YP_177662.1	CDS	Rv2250A	NC_000962.2	2525402	2525821	D	Rv2250A, len: 139 aa. Conserved hypothetical protein, possibly flavoprotein. Similar to N-terminus of SCF91.28c|AL132973_28 possible flavoprotein from Streptomyces coelicolor (530 aa), FASTA scores: opt: 240, E(): 1.1e-07, (39.25% identity in 107 aa overlap). Possible frameshift between nt 2525723 to 2525727. The sequences of CDC 1551 and Mycobacterium bovis are missing a single G base.; flavoprotein	2525402..2525821	Mycobacterium tuberculosis H37Rv	3205100
NP_216767.1	CDS	Rv2251	NC_000962.2	2525565	2526992	D	Rv2251, (MTV022.01), len: 475 aa. Possible flavoprotein, probably continuation of Rv2250A, similar to MTCY164.18 from Mycobacterium tuberculosis and to several ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASES (e.g. O00116). Also some similarity to D-lactate dehydrogenases. FASTA scores: sptr|O05784|O05784 HYPOTHETICAL 56.5 kDa PROTEIN. (527 aa) opt: 1019 E(): 0; (38.6% identity in 487 aa overlap) and sp|O00116|ADAS_HUMAN ALKYLDIHYDROXYACETON EPHOSPHATE SYNTHASE PRECURSOR (EC 2.5.1.26) (658 aa) opt: 558 E(): 6.2e-27; (31.3% identity in 447 aa overlap). TBparse score is 0.902; flavoprotein	2525565..2526992	Mycobacterium tuberculosis H37Rv	888706
NP_216768.1	CDS	Rv2252	NC_000962.2	2526989	2527918	D	involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids; diacylglycerol kinase	2526989..2527918	Mycobacterium tuberculosis H37Rv	888429
NP_216769.1	CDS	Rv2253	NC_000962.2	2527984	2528487	D	Rv2253, (MTV022.03), len: 167 aa. Possible secreted protein; has potential N-terminal signal peptide. TBparse score is 0.945.; hypothetical protein	2527984..2528487	Mycobacterium tuberculosis H37Rv	888287
NP_216770.1	CDS	Rv2254c	NC_000962.2	2528520	2528975	R	Rv2254c, (MTV022.04c), len: 151 aa. Probable integral membrane protein. TBparse score is 0.928.; integral membrane protein	complement(2528520..2528975)	Mycobacterium tuberculosis H37Rv	887182
NP_216771.1	CDS	Rv2255c	NC_000962.2	2528980	2529174	R	Rv2255c, (MTV022.05c), len: 64 aa. Hypothetical unknown protein. TBparse score is 0.904.; hypothetical protein	complement(2528980..2529174)	Mycobacterium tuberculosis H37Rv	885526
NP_216772.1	CDS	Rv2256c	NC_000962.2	2529341	2529874	R	Rv2256c, (MTV022.06c), len: 177 aa. Conserved hypothetical protein, similar to Streptomyces glaucescens ORF5 (164 aa) and Streptomyces coelicolor hypothetical protein SC4A7.19c (164 aa; emb|CAB62723.1|AL133423). FASTA scores: sptr|Q54209|Q54209 FABD, FABH, FABC, FABB, AND ORF5 (164 aa) opt: 504, E(): 3.9e-27; (44.4% identity in 162 aa overlap). TBparse score is 0.900; hypothetical protein	complement(2529341..2529874)	Mycobacterium tuberculosis H37Rv	885865
NP_216773.1	CDS	Rv2257c	NC_000962.2	2530004	2530822	R	Rv2257c, (MTV022.07c), len: 272 aa. Conserved hypothetical protein, similar to hypothetical protein SC4A7.08 from Streptomyces coelicolor (273 aa; 58% identity in 243 aa overlap). Also similar to several putative esterases and penicillin-binding proteins in M. tuberculosis e.g. Rv1923, Rv1497, Rv2463, Rv3775, Rv1922, Rv1730c. TBparse score is 0.896.; hypothetical protein	complement(2530004..2530822)	Mycobacterium tuberculosis H37Rv	888069
NP_216774.1	CDS	Rv2258c	NC_000962.2	2530836	2531897	R	Rv2258c, (MTV022.08c), len: 353 aa. Possible transcriptional regulatory protein, similar to several hypothetical proteins from C. elegans. FASTA scores: sptr|O01593|O01593 CODED FOR BY C. ELEGANS CDNA YK102 F (365 aa) opt: 577, E(): 6.4e-31; (30.5% identity in 341 aa overlap). Contains possible helix-turn helix motif at aa 47-68 (+3.65 SD); transcriptional regulator	complement(2530836..2531897)	Mycobacterium tuberculosis H37Rv	888755
NP_216775.1	CDS	adhE2	NC_000962.2	2532245	2533330	D	Rv2259, (MTV022.09), len: 361 aa. Probable adhE2, zinc-containing alcohol dehydrogenase, similar to several, especially mycothiol-dependent formaldehyde dehydrogenase from Amycolatopsis methanolica P80094 (360 aa). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. FASTA scores: >sp|P80094|FADH_AMYME NAD/MYCOTHIOL-DEPENDENT FORMALDEHYDE DEHYDROGENASE (MD-FALDH) Length = 360, Expect = e-156, Identities = 268/358 (74%). TBparse score is 0.882. Also similar to Rv0162c, (MTCI28.02c, 35.0% identity in 371 aa overlap).; zinc-dependent alcohol dehydrogenase AdhE2	2532245..2533330	Mycobacterium tuberculosis H37Rv	887215
NP_216776.1	CDS	Rv2260	NC_000962.2	2533330	2533965	D	Rv2260, (MTV022.10), len: 211 aa. Conserved hypothetical protein, similar to hypothetical proteins Rv0634c, Rv1637c, Rv3677c, Rv2581c from Mycobacterium tuberculosis and to various hydrolases. FASTA scores: sptr|O06154|O06154 HYPOTHETICAL 21.3 kDa PROTEIN (200 aa) opt: 355, E(): 4e- 15; (37.4% identity in 198 aa overlap). TBparse score is 0.901; hypothetical protein	2533330..2533965	Mycobacterium tuberculosis H37Rv	888490
NP_216777.1	CDS	Rv2261c	NC_000962.2	2534042	2534464	R	Rv2261c, (MTV022.11c), len: 140 aa. Conserved hypothetical protein, with function unknown but some similarity to C-terminal end of PCC6803 apolipoprotein N-acyltransferase from Synechocystis sp. Note that next ORF shows similarity to N-terminal part of P74055 APOLIPOPROTEIN N-ACYLTRANSFERASE from Escherichia coli (519 aa), FASTA scores: opt: 142, E(): 0.007, (29.9% identity in 117 aa overlap), suggesting possible frameshift. Sequence of clones from two sources has been checked but no error found. TBparse score is 0.914.; hypothetical protein	complement(2534042..2534464)	Mycobacterium tuberculosis H37Rv	887455
NP_216778.1	CDS	Rv2262c	NC_000962.2	2534470	2535552	R	Rv2262c, (MTV022.12c), len: 360 aa. Conserved hypothetical protein, with function unknown but some similarity to N-terminal 70% of P23930|P77703|LNT_ECOLI|CUTE|B0657 APOLIPOPROTEIN N-ACYLTRANSFERASE (EC 2.3.1.-) from Escherichia coli strain K12 (512 aa), FASTA scores: opt: 239, E(): 1.6e-07, (30.4% identity in 359 aa overlap). Note that neighboring ORF shows similarity to N -terminal part of PCC6803 apolipoprotein N-acyltransferase from Synechocystis sp., suggesting possibility of frameshift. Sequence of clones from two sources has been checked but no error found. Appear to be two extra bases at position 1876970 compared to CDC1551 strain. TBparse score is 0.932.; hypothetical protein	complement(2534470..2535552)	Mycobacterium tuberculosis H37Rv	887220
NP_216779.1	CDS	Rv2263	NC_000962.2	2535641	2536594	D	Rv2263, (MTV022.13), len: 317 aa. Possible oxidoreductase (EC 1.-.-.-), similar to several oxidoreductases. Similarity suggests alternative GTG start at 10154 but then no rbs. FASTA scores: sptr|Q544 05|Q54405 PROBABLY AN NADP-DEPENDENT OXIDOREDUCTASE (297 aa) opt: 487, E(): 1.1e-23; (36.1% identity in 299 aa overlap). Also similar to Mycobacterium tuberculosis Rv0068, and Rv0439c. TBparse score is 0.889; short chain dehydrogenase	2535641..2536594	Mycobacterium tuberculosis H37Rv	887788
NP_216780.1	CDS	Rv2264c	NC_000962.2	2536572	2538350	R	Rv2264c, (MTV022.14c), len: 592 aa. Conserved hypothetical Pro-rich protein, similar to hypothetical proteins Rv0312 (MTCY63.17, 620 aa and Rv0350) that has highly Pro-, Thr-rich C-terminus. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. FASTA scores: Z96800|MTCY63_17 Mycobacterium tuberculosis cosmid (620 aa) opt: 1075, E(): 8.8e-24; (38.9% identity in 627 aa overlap). TBparse score is 0.919; hypothetical protein	complement(2536572..2538350)	Mycobacterium tuberculosis H37Rv	888040
NP_216781.1	CDS	Rv2265	NC_000962.2	2538700	2539929	D	Rv2265, (MTCY339.45c), len: 409 aa. Possible conserved integral membrane protein, with some similarity to others e.g. M. thermoauto. sp|O26855|O26855 CONSERVED PROTEIN (383 aa), FASTA score: opt: 898 z-score: 1023.5 E(): 0; 38.0% identity in 384 aa overlap; Q58713 HYPOTHETICAL 44.1 kDa PROTEIN 1 317 (398 aa), FASTA scores, opt: 305 E(): 1.2e-11; 22.8% identity in 382 aa overlap; also KGTP_ECOLI P17448 alpha-ketoglutarate permease (432 aa), FASTA scores, opt: 156, E(): 0.006, (24.8% identity in 416 aa overlap); integral membrane protein	2538700..2539929	Mycobacterium tuberculosis H37Rv	887976
NP_216782.1	CDS	cyp124	NC_000962.2	2540104	2541390	D	Rv2266, (MT2328, MTCY339.44c), len: 428 aa. Probable cyp124, cytochrome P450 (EC 1.14.-.-), similar to e.g. G405543 cytochrome P450 (406 aa), FASTA scores, opt: 763,E(): 0, (35.4% identity in 393 aa overlap), similar to e.g. MTCY50.26, 33.8% identity in 370 aa overlap; cytochrome P450 124 CYP124	2540104..2541390	Mycobacterium tuberculosis H37Rv	887763
NP_216783.1	CDS	Rv2267c	NC_000962.2	2541644	2542810	R	Rv2267c, (MTCY339.43), len: 388 aa. Conserved hypothetical protein; some similarity to Mycobacterium tuberculosis Rv3529c; gp|Z82098|MTCY3C7_27 (384 aa) FASTA score: opt: 261, E(): 3.6e-10; 27.3% identity in 253 aa overlap; hypothetical protein	complement(2541644..2542810)	Mycobacterium tuberculosis H37Rv	888487
NP_216784.1	CDS	cyp128	NC_000962.2	2542807	2544276	R	Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450 (EC 1.14.-.-), similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33, (31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature, similar to MTCY50.26, 32.7% identity in 382 aa overlap; cytochrome P450 128	complement(2542807..2544276)	Mycobacterium tuberculosis H37Rv	888025
NP_216785.1	CDS	Rv2269c	NC_000962.2	2544289	2544621	R	Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF.; hypothetical protein	complement(2544289..2544621)	Mycobacterium tuberculosis H37Rv	887623
NP_216786.1	CDS	lppN	NC_000962.2	2544698	2545225	D	Rv2270, (MTCY339.40c), len: 175 aa. Probable lppN, lipoprotein; has appropriately positioned prokaryotic membrane lipoprotein attachment site PS00013.; lipoprotein lppN	2544698..2545225	Mycobacterium tuberculosis H37Rv	887448
NP_216787.1	CDS	Rv2271	NC_000962.2	2545332	2545631	D	Rv2271, (MTCY339.39c), len: 99 aa. Conserved hypothetical protein; some similarity to hypothetical protein AAK01340.1|AF265275_3 (AF265275) from uncultured organism Pu8 (104 aa) E= 4e-10, (34% identity in 91 aa overlap); hypothetical protein	2545332..2545631	Mycobacterium tuberculosis H37Rv	887223
NP_216788.1	CDS	Rv2272	NC_000962.2	2545737	2546105	D	Rv2272, (MTCY339.38c), len: 122 aa. Probable conserved transmembrane PROTEIN, similar to YIDH_ECOLI P31445 hypothetical 12.8 kDa protein (115 aa), FASTA scores, opt: 291, E(): 2.9e-14, (45.6% identity in 103 aa overlap), similar to MTCY339.37c, (35.0% identity in 100 aa overlap).; transmembrane protein	2545737..2546105	Mycobacterium tuberculosis H37Rv	887459
NP_216789.1	CDS	Rv2273	NC_000962.2	2546102	2546431	D	Rv2273, (MTCY339.37c), len: 109 aa. Probable conserved transmembrane protein, similar to Rv2272 (MTCY339.38c), (35.0% identity in 100 aa overlap).; transmembrane protein	2546102..2546431	Mycobacterium tuberculosis H37Rv	888440
NP_216790.1	CDS	Rv2274c	NC_000962.2	2546488	2546805	R	Rv2274c, (MTCY339.36), len: 105 aa. Unknown protein; questionable ORF.; hypothetical protein	complement(2546488..2546805)	Mycobacterium tuberculosis H37Rv	888067
NP_216791.1	CDS	Rv2275	NC_000962.2	2546883	2547752	D	Rv2275, (MTCY339.35c), len: 289 aa. Conserved hypothetical protein. Some similarity to Bacillus subtilis sp|O34351|O34351 YVMC (248 aa), FASTA score: opt: 280, E(): 2.7e -11; 28.2% identity in 227 aa overlap; hypothetical protein	2546883..2547752	Mycobacterium tuberculosis H37Rv	888355
NP_216792.1	CDS	cyp121	NC_000962.2	2547749	2548939	D	Rv2276, (MT2336, MTCY339.34c), len: 396 aa. cyp121, cytochrome P450 (EC 1.14.-.-) (see citation below), similar to e.g. G303644 (397 aa) opt: 675, z-score: 776.4, E(): 2.7e-36, (33.7% identity in 407 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature, similar to MTCY339.42, 29.2% identity in 298 aa overlap.; cytochrome P450 121 CYP121	2547749..2548939	Mycobacterium tuberculosis H37Rv	888373
NP_216793.1	CDS	Rv2277c	NC_000962.2	2549124	2550029	R	Rv2277c, (MTCY339.33), len: 301 aa. Possible glycerolphosphodiesterase, similar to e.g. UGPQ_ECOLI P10908 glycerophosphoryldiester phosphodiesterase (cytosolic) (247 aa), FASTA scores, opt: 149, E(): 0.0061, (27.2% identity in 195 aa overlap). Start of protein uncertain, encoded by neighbouring IS6110 as given, is intact in Mycobacterium tuberculosis CDC1551; glycerolphosphodiesterase	complement(2549124..2550029)	Mycobacterium tuberculosis H37Rv	888498
NP_216794.1	CDS	Rv2278	NC_000962.2	2550065	2550391	D	Rv2278, (MTCY339.32c), len: 108 aa. Probable IS6110 transposase nearly identical to SW:YI32_MYCTU P19772 insertion element IS986 hypothetical (96.6% identity in 59 aa overlap), similar to TR:G309867 IS401 transposase subunit (51.4% identity in 105 aa overlap), predicted region of coiled coil at C-terminus.; transposase	2550065..2550391	Mycobacterium tuberculosis H37Rv	888602
NP_216795.1	CDS	Rv2279	NC_000962.2	<2550388	2551326	D	Rv2279, (MTCY339.31c), len: 312 aa. Probable IS6110 transposase , nearly identical to TRA9_MYCTU P19774 putative transposase for insertion sequence IS986 orfB, (278 aa), FASTA scores, opt: 1859, E(): 0, (99.6% identity in 278 aa overlap).; transposase	<2550388..2551326	Mycobacterium tuberculosis H37Rv	887746
NP_216796.1	CDS	Rv2280	NC_000962.2	2551560	2552939	D	Rv2280, (MTCY339.30c), len: 459 aa. Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa overlap), similar to MTCY50.25, 36.5% identity in 447 aa overlap; dehydrogenase	2551560..2552939	Mycobacterium tuberculosis H37Rv	887601
NP_216797.1	CDS	pitB	NC_000962.2	2553173	2554831	D	Rv2281, (MTCY339.29c), len: 552 aa. Putative pitB, phosphate-transport permease, integral membrane protein, similar to YG04_HAEIN P45268 putative phosphate permease hi1604 (420 aa). FASTA scores, opt: 484, E(): 5e-23, (33.5% identity in 498 aa overlap) also to G399598 amphotropic murine retrovirus receptor (656 aa) FASTA scores, opt: 453, E(): 5.8e-21, (26.8% identity in 645 aa overlap). Also similar to Rv0545c|pitA from M. tuberculosis. BELONGS TO THE PIT SUBFAMILY.; phosphate ABC transporter permease	2553173..2554831	Mycobacterium tuberculosis H37Rv	887257
NP_216798.1	CDS	Rv2282c	NC_000962.2	2554938	2555876	R	Rv2282c, (MTCY339.28), len: 312 aa. Probable transcriptional regulator, lysR family, similar to others e.g. YC30_CYAPA|P48271 hypothetical transcriptional regulator YCF30 (324 aa), FASTA scores: opt: 292, E(): 4e-12, (27.6% identity in 286 aa overlap); etc. Also similar to Rv0377|MTCY39.34 from Mycobacterium tuberculosis, FASTA score: (25.4% identity in 268 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature, and contains helix-turn-helix motif at aa 24 -45 (+4.93 SD).; LysR family transcriptional regulator	complement(2554938..2555876)	Mycobacterium tuberculosis H37Rv	887253
NP_216799.1	CDS	Rv2283	NC_000962.2	2555941	2556135	D	Rv2283, (MTCY339.27c), len: 64 aa. Unknown protein; questionable ORF.; hypothetical protein	2555941..2556135	Mycobacterium tuberculosis H37Rv	887644
NP_216800.1	CDS	lipM	NC_000962.2	2556145	2557440	D	Rv2284, (MTCY339.26c), len: 431 aa. Probable lipM, esterase (EC 3.1.-.-), similar to others e.g. gp|Z95844|MTCY493_28 from Mycobacterium tuberculosis cosmid (420 aa), FASTA scores: opt: 1266, E(): 0, (50.1% identity in 411 aa overlap). Some similarity to G537514 arylacetamide deacetylase (399 aa), FASTA scores: opt: 190, E(): 5.9e-05, (30.4% identity in 138 aa overlap).; esterase LipM	2556145..2557440	Mycobacterium tuberculosis H37Rv	887794
NP_216801.1	CDS	Rv2285	NC_000962.2	2557473	2558810	D	Rv2285, (MTCY339.25c), len: 445 aa. Conserved hypothetical protein, member of Mycobacterium tuberculosis 15-membered protein family including Rv3740c, Rv3734c, Rv1425, Rv1760, Rv0895, Rv3480c. FASTA scores: gp|Z95844|MTCY493_29 Mycobacterium tuberculosis cosmid (459 aa) opt: 640, E(): 0; 33.4% identity in 470 aa overlap.; hypothetical protein	2557473..2558810	Mycobacterium tuberculosis H37Rv	888632
NP_216802.1	CDS	Rv2286c	NC_000962.2	2558877	2559569	R	Rv2286c, (MTCY339.24), len: 230 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein, Rv2466c, AL021246|MTV008_22 (207 aa). FASTA score: opt: 324, E(): 8.9e-15; 30.4% identity in 194 aa overlap; hypothetical protein	complement(2558877..2559569)	Mycobacterium tuberculosis H37Rv	887395
NP_216803.1	CDS	yjcE	NC_000962.2	2559703	2561331	D	Rv2287, (MTCY339.23c), len: 542 aa. Probable yjcE, conserved integral membrane transport protein, similar to eukaryote NA+/H+ exchangers e.g. YJCE_ECOLI|P32703|B4065 Putative Na(+)/H(+) exchanger from Escherichia coli (549 aa), FASTA scores: opt: 436, E(): 5.6e-21, (29.4% identity in 555 aa overlap); etc. SEEMS TO BELONG TO CPA1 FAMILY (NA(+)/H(+) EXCHANGER FAMILY).; integral membrane transport protein YjcE	2559703..2561331	Mycobacterium tuberculosis H37Rv	887570
NP_216804.1	CDS	Rv2288	NC_000962.2	2561328	2561705	D	Rv2288, (MTCY339.22c), len: 125 aa. Unknown hypothetical protein; hypothetical protein	2561328..2561705	Mycobacterium tuberculosis H37Rv	887702
NP_216805.1	CDS	cdh	NC_000962.2	2561675	2562457	D	Rv2289, (MTCY339.21c), len: 260 aa. Probable cdh, CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26), similar to CDH_SALTY|P26219 cdp-diacylglycerol pyrophosphatase (251 aa), FASTA scores: opt: 395, E(): 5.9e-20, (33.5% identity in 221 aa overlap).; CDP-diacylglycerol pyrophosphatase	2561675..2562457	Mycobacterium tuberculosis H37Rv	887342
NP_216806.1	CDS	lppO	NC_000962.2	2562599	2563114	D	Rv2290, (MTCY339.20c), len: 171 aa. Probable lppO, conserved lipoprotein, similar to Rv3763, 19KD_MYCTU P11572 19 kDa lipoprotein antigen precursor (159 aa) FASTA scores, opt: 119, E (): 1.3, (25.6% identity in 164 aa overlap). Contains appropriately positioned PS00013 lipoprotein motif (with one mismatch).; lipoprotein lppO	2562599..2563114	Mycobacterium tuberculosis H37Rv	887203
NP_216807.1	CDS	sseB	NC_000962.2	2563174	2564028	D	Rv2291, (MTCY339.19c), len: 284 aa. Probable sseB, thiosulfate sulfurtransferase. Very similar to thiosulfate sulfurtransferas/rhodanese from Streptomyces coelicolor AL00920 4|SC9B10_21 (283 aa) opt: 765, E(): 0; Smith-Waterman score: 765; 46.9% identity in 286 aa overlap, similar to THTR_ECOLI P31142 putative thiosulfate sulfurtransferase (280 aa), FASTA scores, opt: 478, E(): 1e-23, (35.1% identity in 265 aa overlap); thiosulfate sulfurtransferase SseB	2563174..2564028	Mycobacterium tuberculosis H37Rv	887174
NP_216808.1	CDS	Rv2292c	NC_000962.2	2564029	2564253	R	Rv2292c, (MTCY339.18), len: 74 aa. Unknown hypothetical protein; hypothetical protein	complement(2564029..2564253)	Mycobacterium tuberculosis H37Rv	888805
NP_216809.1	CDS	Rv2293c	NC_000962.2	2564292	2565032	R	Rv2293c, (MTCY339.17), len: 246 aa. Conserved hypothetical protein; some similarity to hypothetical protein (299 aa) AAK24237.1| (AE005897) belonging to phosphorylase family [Caulobacter crescentus] (33% identity in 131 aa overlap). Possible lipoprotein: signal peptide at N-terminus; hypothetical protein	complement(2564292..2565032)	Mycobacterium tuberculosis H37Rv	887283
NP_216810.1	CDS	Rv2294	NC_000962.2	2565327	2566550	D	Rv2294, (MTCY339.16c), len: 407 aa. Probable aminotransferase (EC 2.6.1.-), similar to others in M. tuberculosis e.g. MTV030_19, also similar to PATB_BACSU|Q08432 putative aminotransferase b from Bacillus subtilis (387 aa), FASTA scores: opt: 563, E(): 2 .8e-29, (31.4% identity in 408 aa overlap); and to MALY_ECOLI|P23256 maly protein from Escherichia coli (390 aa), FASTA scores: opt: 530, E(): 3.6e-27, (31.3% identity in 384 aa overlap). BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES.; aminotransferase	2565327..2566550	Mycobacterium tuberculosis H37Rv	885868
NP_216811.1	CDS	Rv2295	NC_000962.2	2566772	2567410	D	Rv2295, (MTCY339.15c), len: 212 aa. Conserved hypothetical protein, cysteine-rich protein, similar to YIEJ_ECOLI P31469 hypothetical 22.5 kDa protein in tnab-bglb intergenic region (195 aa), opt: 270, E(): 3.4e-11, (36.4% identity in 198 aa overlap). Alternative start suggested by similarity 26 codons further downstream; hypothetical protein	2566772..2567410	Mycobacterium tuberculosis H37Rv	888540
NP_216812.1	CDS	Rv2296	NC_000962.2	2567504	2568406	D	Rv2296, (MTCY339.14c), len: 300 aa. Probable haloalkane dehalogenase (EC 3.8.1.5), similar to e.g. HALO_XANAU P22643, haloalkane dehalogenase, (310 aa), opt: 510 z-score: 577.7 E(): 3.1e-25 (39.0% identity in 315 aa overlap).; haloalkane dehalogenase	2567504..2568406	Mycobacterium tuberculosis H37Rv	887796
NP_216813.1	CDS	Rv2297	NC_000962.2	2568438	2568890	D	Rv2297, (MTCY339.13c), len: 150 aa. Unknown protein; contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide; hypothetical protein	2568438..2568890	Mycobacterium tuberculosis H37Rv	887789
NP_216814.1	CDS	Rv2298	NC_000962.2	2569082	2570053	D	Rv2298, (MTCY339.12c), len: 323 aa. Conserved hypothetical protein. Similar to SLR0545 Synechocystis sp, Q55493 hypothetical 34.6 kDa protein (314 aa), FASTA scores, opt: 427, E(): 1.7e-20, (39.3% identity in 303 aa overlap) and to YZAE_BACSU P46905 hypothetical protein in natb 3'region (268 aa) FASTA scores, opt: 370, E(): 6.1e-17, (31.4% identity in 264 aa overlap); hypothetical protein	2569082..2570053	Mycobacterium tuberculosis H37Rv	887344
NP_216815.1	CDS	htpG	NC_000962.2	2570059	2572002	R	molecular chaperone; heat shock protein 90	complement(2570059..2572002)	Mycobacterium tuberculosis H37Rv	887501
NP_216816.1	CDS	Rv2300c	NC_000962.2	2572076	2573008	R	Rv2300c, (MTCY339.09), len: 310 aa (start uncertain). Conserved hypothetical protein, similar to others e.g. Q9RXY2|DR0172 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (271 aa), FASTA scores: opt: 306, E(): 1.3e-12, (34.6% identity in 229 aa overlap); Q9HZH1|PA3037 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (288 aa), FASTA scores: opt: 248, E(): 7.9e-09, (31.5% identity in 238 aa overlap); Q9PDL8|XF1361 HYPOTHETICAL PROTEIN from Xylella fastidiosa (279 aa), FASTA scores: opt: 236, E(): 4.6e-08, (29.7% identity in 249 aa overlap); U70053|XCU70053_3 GumP PROTEIN from Xanthomonas campestris (282 aa), FASTA scores: opt: 222, E(): 3.7e-07, (30.1% identity in 248 aa overlap); etc.; hypothetical protein	complement(2572076..2573008)	Mycobacterium tuberculosis H37Rv	887880
NP_216817.2	CDS	cut2	NC_000962.2	2573015	2573707	D	Rv2301, (MTCY339.08c), len: 230 aa. Probable cut2 (alternate gene name: cfp25), cutinase (EC 3.1.1.-), highly similar to others from Mycobacteria tuberculosis e.g. MTCY13E12.04|Rv3451|O06318|CUT3_MYCTU (247 aa), FASTA scores: opt: 569, E(): 2.3e-27, (45.3% identity in 223 aa overlap); MT2037|MTCY39.35|RV1984C|Q10837|CUT1_MYCTU (217 aa), FASTA scores: opt: 383, E(): 3.4e-16 (42.9% identity in 217 aa overlap); O69691|Rv3724|MTV025.072 PUTATIVE CUTINASE PRECURSOR (187 aa), FASTA scores: opt: 248, E(): 4.3e-08, (41.85% identity in 172 aa overlap); etc. Also similar to few others from other organisms e.g. Q9KK87 SERINE ESTERASE CUTINASE from Mycobacterium avium (220 aa), FASTA scores: opt: 391, E(): 1.1e-16, (39.15% identity in 235 aa overlap); etc. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. BELONGS TO THE CUTINASE FAMILY. Start changed since first submission (+11 aa).; cfp25; cutinase CUT2	2573015..2573707	Mycobacterium tuberculosis H37Rv	885371
NP_216818.1	CDS	Rv2302	NC_000962.2	2573813	2574055	D	Rv2302, (MTCY339.07c), len: 80 aa. Conserved hypothetical protein, highly similar to others: O53766|AL021942|Rv0569|MTV039.07 HYPOTHETICAL 9.5 KDA PROTEIN from Mycobacterium tuberculosis (88 aa), FASTA scores: opt: 300, E(): 1.4e-14, (61.85% identity in 76 aa overlap); O88049|SCI35.11 HYPOTHETICAL 7.1 KDA PROTEIN from Streptomyces coelicolor (64 aa), FASTA scores: opt: 169, E(): 1.5e-05, (46.55% identity in 58 aa overlap) (has its C-terminus shorter); Q9XCD1 HYPOTHETICAL 12.0 KDA PROTEIN (FRAGMENT) from Thermomonospora fusca (106 aa), FASTA scores: opt: 126, E(): 0.023, (50.0% identity in 34 aa overlap) (similarity in part for this one). Also weakly similar to U650M|G699303|Q50105 HYPOTHETICAL 5.7 KDA PROTEIN from Mycobacterium leprae (53 aa), FASTA scores: opt: 89, E(): 0.66, (45.5% identity in 33 aa overlap); and weakly similar to N-terminus of Q9RIZ1|SCJ1.23c putative DNA-binding protein from Streptomyces coelicolor (323 aa), FASTA scores: opt: 182, E(): 7.3e-06, (42.25% identity in 71 aa overlap).; hypothetical protein	2573813..2574055	Mycobacterium tuberculosis H37Rv	885154
NP_216819.1	CDS	Rv2303c	NC_000962.2	2574096	2575019	R	Rv2303c, (MTCY339.06, MT2360), len: 307 aa. Probable antibiotic-resistance protein, with some similarity to Q54229|G153373 macrotetrolide antibiotic-resistance protein (NONR) from Streptomyces griseus (347 aa) (see the first citation below), FASTA scores: opt: 438, E(): 3.1e-21, (33.2% identity in 226 aa overlap); and other hypothetical proteins e.g. P95886 ORF C02006 from Sulfolobus solfataricus (269 aa), FASTA scores: opt: 252, E(): 3.5e-09, (25.5% identity in 286 aa overlap); etc. Also similar to Mycobacterium tuberculosis Rv3510c|O53555|MTV023.17. Note that the protein Q9XDF3|NONC from Streptomyces griseus subsp. griseus (317 aa) is equivalent to Q54229|G153373|NONR however the N-terminal end is shorter (30 aa) owing to a changed start codon (see the second citation below).; antibiotic-resistance protein	complement(2574096..2575019)	Mycobacterium tuberculosis H37Rv	885282
NP_216820.1	CDS	Rv2304c	NC_000962.2	2575016	2575225	R	Rv2304c, (MTCY339.05), len: 69 aa. Hypothetical unknown protein.; hypothetical protein	complement(2575016..2575225)	Mycobacterium tuberculosis H37Rv	885102
NP_216821.1	CDS	Rv2305	NC_000962.2	2575809	2577098	D	Rv2305, (MTCY339.04c), len: 429 aa. Hypothetical unknown protein.; hypothetical protein	2575809..2577098	Mycobacterium tuberculosis H37Rv	885752
YP_177663.1	CDS	Rv2306A	NC_000962.2	2577108	2577701	D	Rv2306A, len: 197 aa. Possible conserved membrane protein, similar to several hypothetical membrane proteins from Mycobacterium tuberculosis and Streptomyces coelicolor, e.g. Rv0625c|P96915|Y625_MYCTU HYPOTHETICAL 25.2 KDA PROTEIN from Mycobacterium tuberculosis (246 aa), FASTA scores: opt: 410, E(): 2.7e-17, (53.25% identity in 139 aa overlap). First 140 aa show high similarity, this then decreases but continues in next ORF Rv2306B, suggesting a frameshift near nt 2577473. However the sequence has been checked and no error found. The sequence is identical in CDC1551 and Mycobacterium bovis. Replaces original Rv2306c on other strand.; hypothetical protein	2577108..2577701	Mycobacterium tuberculosis H37Rv	3205062
YP_177664.1	CDS	Rv2306B	NC_000962.2	2577488	2577922	D	Rv2306B, len: 144 aa. Possible conserved membrane protein, similar to C-terminal part of several hypothetical membrane proteins from Mycobacterium tuberculosis and Streptomyces coelicolor e.g. P96915|Y625_MYCTU|RV0625c HYPOTHETICAL 25.2 KDA PROTEIN from Mycobacterium tuberculosis (246 aa), FASTA scores: opt: 480, E(): 5e-24, (77.15% identity in 92 aa overlap). Could be a continuation of Rv2306A suggesting there may be a frameshift near nt 2577473. The C-terminal part is longer than Rv0625c and the 3'-end of gene overlaps Rv2307c, so maybe a further framehift. However, sequence has been checked and no error found. Also same sequence as strain CDC1551 and Mycobacterium bovis. Replaces original Rv2306c on other strand.; hypothetical protein	2577488..2577922	Mycobacterium tuberculosis H37Rv	3205063
NP_216823.1	CDS	Rv2307c	NC_000962.2	2577851	2578696	R	Rv2307c, (MTCY339.02), len: 281 aa. Conserved hypothetical protein, similar to many other hypothetical proteins and BEM1/BUD5 suppressors e.g. P77538 HYPOTHETICAL PROTEIN from Escherichia coli (293 aa), FASTA scores: opt: 421, E(): 2.4e-18, (32.1% identity in 268 aa overlap) (alias AAG57647|Z3802|BAB36823|ECS3400 Putative enzyme (3.4.-) from Escherichia coli (293 aa), FASTA scores: opt: 425, E(): 1.7e-18, (32.1% identity in 268 aa overlap));P54069|BE46_SCHPO|BEM46|SPBC32H8.03|PI020 BEM46 PROTEIN from Schizosaccharomyces pombe (Fission yeast) (352 aa), FASTA scores: opt: 355, E(): 3.3e-14, (30.45% identity in 279 aa overlap); O76462|BEM46 BEM46 PROTEIN from Drosophila melanogaster (338 aa), FASTA scores: opt: 404, E(): 2.8e-17, (32.75% identity in 281 aa overlap); etc. Equivalent (but with few differences) to AAK46650|MT2364 protein from Mycobacterium tuberculosis strain CDC1551 (281 aa).; hypothetical protein	complement(2577851..2578696)	Mycobacterium tuberculosis H37Rv	885277
YP_177665.1	CDS	Rv2307A	NC_000962.2	2579228	2579419	R	Rv2307A, len: 63 aa. Hypothetical unknown protein.; glycine rich protein	complement(2579228..2579419)	Mycobacterium tuberculosis H37Rv	3205073
YP_177666.1	CDS	Rv2307B	NC_000962.2	2579504	2579935	R	Rv2307B, len: 143 aa. Hypothetical unknown Gly- rich protein. Equivalent to AAK46653 from Mycobacterium tuberculosis strain CDC1551 (133 aa) but longer 10 aa.; glycine rich protein	complement(2579504..2579935)	Mycobacterium tuberculosis H37Rv	3205074
YP_177667.1	CDS	Rv2307D	NC_000962.2	2580028	2580210	R	Rv2307D, len: 60 aa. Hypothetical unknown protein.; hypothetical protein	complement(2580028..2580210)	Mycobacterium tuberculosis H37Rv	3205075
NP_216824.1	CDS	Rv2308	NC_000962.2	2580419	2581135	D	Rv2308, (MTCY339.01c), len: 238 aa. Conserved hypothetical protein, sharing similarity with O53464|Rv2018|MTV018.05 from Mycobacterium tuberculosis (239 aa), FASTA scores: opt: 142, E(): 0.034, (24.8% identity in 250 aa overlap). As contains possible helix-turn-helix motif at aa 16-37 (Sequence: YVYAEVDKLIGLPAGTAKRWIN) (Score 1169, +3.17 SD), may be a transcriptional regulator.; hypothetical protein	2580419..2581135	Mycobacterium tuberculosis H37Rv	885290
NP_216825.1	CDS	Rv2309c	NC_000962.2	2581843	2582298	R	Rv2309c, (MTCY3G12.25), len: 151 aa. Possible integrase (fragment), similar to others e.g. Q48908 INTEGRASE (FRAGMENT) from Mycobacterium paratuberculos (191 aa), FASTA scores: opt: 279, E(): 3.2e-11, (40.4% identity in 136 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv1055|MTV017.08 INTEGRASE (FRAGMENT) (78 aa) (72.85% identity in 70 aa overlap); and Rv1054|MTV017.07 INTEGRASE (FRAGMENT). COULD BELONG TO THE 'PHAGE' INTEGRASE FAMILY.; hypothetical protein	complement(2581843..2582298)	Mycobacterium tuberculosis H37Rv	885133
YP_177668.1	CDS	Rv2309A	NC_000962.2	2583045	2583332	D	Rv2309A, len: 95 aa. Hypothetical unknown protein. Equivalent to AAK46663 from Mycobacterium tuberculosis strain CDC1551 (95 aa) but longer 13 aa.; hypothetical protein	2583045..2583332	Mycobacterium tuberculosis H37Rv	3205076
NP_216826.1	CDS	Rv2310	NC_000962.2	2583435	2583779	D	Rv2310, (MT2372, MTCY3G12.24c), len: 148 aa. Possible excisionase, showing some similarity to others e.g. Q9LCU5 PUTATIVE EXCISIONASE from Arthrobacter sp. TM1 (174 aa) FASTA scores: opt: 341, E(): 6.6e-15, (48.2% identity in 110 aa overlap); O85865 PUTATIVE EXCISIONASE from Sphingomonas aromaticivorans (152 aa), FASTA scores: opt: 205, E(): 2.2e-06, (41.25% identity in 80 aa overlap); etc. Also similar to Rv3750c|O69717 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 228, E(): 6.9e-08, (43.9% identity in 82 aa overlap). Contains possible helix-turn-helix motif at aa 20-41 (Score 2181, +6.62 SD).; excisionase	2583435..2583779	Mycobacterium tuberculosis H37Rv	885175
NP_216827.1	CDS	Rv2311	NC_000962.2	2583884	2584408	D	Rv2311, (MTCY3G12.23c), len: 174 aa. Conserved hypothetical protein, with similarity (in part) to transfer proteins homologous TRAA e.g. Q9EUN8|TRAA TRANSFER PROTEIN HOMOLOG TRAA from Corynebacterium glutamicum (1160 aa), FASTA scores: opt: 221, E(): 2.9e-07, (36.8% identity in 136 aa overlap); Q9ETQ3|TRAA CONJUGAL TRANSFER PROTEIN (TRAA-LIKE PROTEIN) from Corynebacterium equii (1367 aa), FASTA scores: opt: 188, E(): 5.5e-05, (33% identity in 106 aa overlap); P55418|TRAA_RHISN|Y4DS PROBABLE CONJUGAL TRANSFER PROTEIN from Rhizobium sp. strain NGR234 (1102 aa), FASTA scores: opt: 145, E(): 0.035, (29.08% identity in 141 aa overlap); etc.; hypothetical protein	2583884..2584408	Mycobacterium tuberculosis H37Rv	885168
NP_216828.1	CDS	Rv2312	NC_000962.2	2584486	2584755	D	Rv2312, (MTCY3G12.22c), len: 89 aa. Hypothetical unknown protein.; hypothetical protein	2584486..2584755	Mycobacterium tuberculosis H37Rv	885152
NP_216829.1	CDS	Rv2313c	NC_000962.2	2585052	2585906	R	Rv2313c, (MTCY3G12.21), len: 284 aa. Hypothetical unknown protein.; hypothetical protein	complement(2585052..2585906)	Mycobacterium tuberculosis H37Rv	885268
NP_216830.1	CDS	Rv2314c	NC_000962.2	2585917	2587290	R	Rv2314c, (MTCY3G12.20), len: 457 aa. Conserved hypothetical protein, highly similar to Q9RJ51|SCI8.02 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (464 aa) FASTA scores: opt: 1485, E(): 5.2e-83, (53.5% identity in 454 aa overlap); similar to AAK24788|CC2824 TldD/PmbA family protein from Caulobacter crescentus (441 aa), FASTA scores: opt: 364, E(): 8.3e-15, (29.8% identity in 460 aa overlap); and showing similarity with Q9HJZ6|TA0814 HYPOTHETICAL PROTEIN from Thermoplasma acidophilum (430 aa), FASTA scores: opt: 220, E(): 4.7e-06, (21.85% identity in 348 aa overlap).; hypothetical protein	complement(2585917..2587290)	Mycobacterium tuberculosis H37Rv	885130
NP_216831.1	CDS	Rv2315c	NC_000962.2	2587287	2588804	R	Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved hypothetical protein, highly similar to Q9S273|SCI28.10 HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (435 aa), FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46, (42.8% identity in 505 overlap); O58578|PH0848 HYPOTHETICAL 54.4 KDA PROTEIN from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, (29.95% identity in 484 aa overlap); Q9UZ95|PAB1547 HYPOTHETICAL 53.6 KDA PROTEIN from Pyrococcus abyssi (473 aa), FASTA scores: opt: 656, E(): 8.6e-33, (29.1% identity in 481 aa overlap); etc.; hypothetical protein	complement(2587287..2588804)	Mycobacterium tuberculosis H37Rv	885260
NP_216832.1	CDS	uspA	NC_000962.2	2588838	2589710	D	Rv2316, (MTCY3G12.18c), len: 290 aa. Probable uspA, sugar-transport integral membrane protein ABC transporter (see citation below), most similar to Q9CBN8|USPA|ML1768 SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (328 aa), FASTA scores: opt: 1593, E(): 1.9e-93, (82.35% identity in 289 aa overlap); and similar to O32940|ML1426|MLCB2052.28 POSSIBLE SUGAR TRANSPORT PROTEIN (PROBABLE ABC-TRANSPORT PROTEIN, INNER MEMBRANE COMPONENT) from Mycobacterium leprae (319 aa), FASTA scores: opt: 600, E(): 9.2e-31, (34.25% identity in 295 aa overlap). Also similar to other proteins involved in transport e.g. Q9X860|SCE134.05c PUTATIVE BINDING PROTEIN DEPENDENT TRANSPORT PROTEIN from Streptomyces coelicolor (327 aa), FASTA scores: opt: 639, E(): 3.2e-33, (40.45% identity in 272 aa overlap); Q9K6N9|BH3689 SUGAR TRANSPORT SYSTEM (PERMEASE) from Bacillus halodurans (300 aa), FASTA scores: opt: 590, E(): 3.7e-30, (35.65% identity in 289 aa overlap); etc.; sugar-transport integral membrane protein ABC transporter UspA	2588838..2589710	Mycobacterium tuberculosis H37Rv	885262
YP_177866.1	CDS	uspB	NC_000962.2	2589697	2590521	D	Rv2317, (MTC3G12.17c), len: 274 aa. Probable uspB, sugar-transport integral membrane protein ABC transporter (see citation below), most similar to Q9CBN7|USPE|ML1769 SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (274 aa), FASTA scores: opt: 1522, E(): 3.4e-89, (85.0% identity in 274 aa overlap); and similar to O32941|ML1425|MLCB2052.29 PROBABLE ABC-TRANSPORT PROTEIN, INNER MEMBRANE COMPONENT from Mycobacterium leprae (283 aa), FASTA scores: opt: 630, E(): 8.4e-33, (36.55% identity in 268 aa overlap). Also similar to other integral membrane proteins e.g. P73854|LACG|SLR1723 LACTOSE TRANSPORT SYSTEM PERMEASE PROTEIN from Synechocystis sp. strain PCC 6803 (270 aa), FASTA scores: opt: 605, E(): 3.1e-31, (36.0% identity in 264 aa overlap); Q9F3B8|SC5F1.11 PUTATIVE SUGAR TRANSPORT INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (307 aa), FASTA scores: opt: 582, E(): 9.7e-30, (34.45% identity in 264 aa overlap); etc. Also similar to O53483|Rv2039c|MTV018.26c SUGAR TRANSPORT PROTEIN from Mycobacterium tuberculosis (280 aa), FASTA scores: opt: 630, E(): 8.3e-89, (37.7% identity in 268 aa overlap).; sugar-transport integral membrane protein ABC transporter UspB	2589697..2590521	Mycobacterium tuberculosis H37Rv	885101
NP_216834.1	CDS	uspC	NC_000962.2	2590518	2591840	D	Rv2318, (MTCY3G12.16c), len: 440 aa. Probable uspC, sugar-binding lipoprotein component of sugar transport system (see citation below), most similar to Q9CBN6|USPC|ML1770 SUGAR TRANSPORT PERIPLASMIC BINDING PROTEIN from Mycobacterium leprae (446 aa), FASTA scores: opt: 2294, E(): 8.1e-135, (74.7% identity in 446 aa overlap). Also similar to other substrate-binding proteins e.g. Q9RK89|SCF1.15 PUTATIVE SUBSTRATE BINDING PROTEIN (EXTRACELLULAR) (BINDING-PROTEIN-DEPENDENT TRANSPORT) (FRAGMENT) from Streptomyces coelicolor (221 aa), FASTA scores: opt: 377, E(): 3e-16, (32.25% identity in 217 aa overlap); Q9K6N8|BH3690 SUGAR TRANSPORT SYSTEM (SUGAR-BINDING PROTEIN) from Bacillus halodurans (420 aa), FASTA scores: opt: 227, E(): 1e-06, (25.00% identity in 452 aa overlap); etc. Also similar to O53485|Rv2041c|MTV018.28C LIPOPROTEIN COMPONENT OF SUGAR TRANSPORT SYSTEM from Mycobacterium tuberculosis (439 aa), FASTA scores: opt: 246, E(): 7e-08, (26.75% identity in 325 aa overlap). Contains a hydrophobic stretch (possible signal peptide) at N-terminal end.; periplasmic sugar-binding lipoprotein UspC	2590518..2591840	Mycobacterium tuberculosis H37Rv	885143
NP_216835.1	CDS	Rv2319c	NC_000962.2	2591848	2592726	R	Rv2319c, (MTCY3G12.15), len: 292 aa. Hypothetical unknown protein.; hypothetical protein	complement(2591848..2592726)	Mycobacterium tuberculosis H37Rv	885171
NP_216836.1	CDS	rocE	NC_000962.2	2592723	2594153	R	Rv2320c, (MTCY3G12.14), len: 476 aa. Probable rocE, cationic amino acid (especially arginine and ornithine) transporter (permease), highly similar to other amino acid transporters e.g. Q9L100|SCL6.16C PUTATIVE AMINO ACID TRANSPORTER from Streptomyces coelicolor (496 aa), FASTA scores: opt: 1485, E(): 9.4e-82, (48.4% identity in 477 aa overlap); O06479|YFNA PUTATIVE AMINO ACID TRANSPORTER from Bacillus subtilis (462 aa), FASTA scores: opt: 1271, E(): 6.1e-69, (41.9% identity in 463 aa overlap); Q9PG94|XF0408 AMINO ACID TRANSPORTER from Xylella fastidiosa (509 aa), FASTA scores: opt: 1128, E(): 2.5e-60, (39.5% identity in 481 aa overlap); etc. Also some similarity with Z99108.1|BSUB0005 from Bacillus subtilis (461 aa), FASTA scores: opt: 1271, E(): 0, (41.9% identity in 463 aa overlap); and G403170 ETHANOLAMINE PERMEASE (488 aa), FASTA scores: opt: 468, E(): 1e-23, (28.1% identity in 462 aa overlap). SEEMS TO BELONG TO THE APC FAMILY.; cationic amino acid transport integral membrane protein RocE	complement(2592723..2594153)	Mycobacterium tuberculosis H37Rv	885084
NP_216837.1	CDS	rocD2	NC_000962.2	2594154	2594699	R	Rv2321c, (MTCY3G12.13), len: 181 aa. Probable rocD2, ornithine aminotransferase (EC: 2.6.1.13), highly similar to C-terminal region of other ornithine aminotransferases, e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa), FASTA scores: opt: 628, E(): 1.2e-32, (55.35% identity in 168 aa overlap); P3802|OAT_BACSU|ROCD from Bacillus subtilis (401 aa), FASTA scores: opt: 477, E(): 4.3e-23, (42.1% identity in 178 aa overlap); BAB42057|ROCD|SA0818 from Staphylococcus aureus subsp. aureus N315 (396 aa), FASTA scores: opt: 437, E(): 1.5e-20, (41.3% identity in 170 aa overlap); etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. Rv2322c|MTCY3G12.12 (upstream ORF) and Rv2321c|MTCY3G12.13 appear to be an ornithine aminotransferase homologue but are frameshifted - we can find no sequence error in the cosmid to account for this.; ornithine aminotransferase	complement(2594154..2594699)	Mycobacterium tuberculosis H37Rv	885056
NP_216838.1	CDS	rocD1	NC_000962.2	2594699	2595364	R	Rv2322c, (MTCY3G12.12), len: 221 aa. Probable rocD1, ornithine aminotransferase (EC: 2.6.1.13), highly similar to N-terminal region of other ornithine aminotransferases, e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa), FASTA scores: opt: 770, E(): 8.7e-40, (55.7% identity in 201 aa overlap); BAB42057|ROCD|SA0818 from Staphylococcus aureus subsp. aureus N315 (396 aa) FASTA scores: opt: 632, E(): 2.2e-31, (46.1% identity in 208 aa overlap); P38021|OAT_BACSU|ROCD from Bacillus subtilis (401 aa), FASTA scores: opt: 626, E(): 5.1e-31, (43.1% identity in 218 aa overlap); etc. BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. Rv2322c|MTCY3G12.12 and Rv2321c|MTCY3G12.13 (upstream ORF) appear to be an ornithine aminotransferase homologue but are frameshifted - we can find no sequence error in the cosmid to account for this.; ornithine aminotransferase	complement(2594699..2595364)	Mycobacterium tuberculosis H37Rv	885096
NP_216839.1	CDS	Rv2323c	NC_000962.2	2595361	2596269	R	Rv2323c, (MTCY3G12.11), len: 302 aa. Conserved hypothetical protein, highly similar to others eg Q9FC91|2SCG58.22 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (288 aa), FASTA scores: opt: 561, E(): 7.3e-28, (46.95% identity in 279 aa overlap); P74535|SLL1336 HYPOTHETICAL 78.3 KDA PROTEIN from Synechocystis sp. (705 aa), FASTA scores: opt: 555, E(): 2.1e-27, (37.75% identity in 265 aa overlap); etc. Also similar to various hydrolases e.g. Q53797 BETA-HYDROXYLASE (BLEOMYCIN/PHLEOMYCIN BINDING PROTEIN, ANKYRIN HOMOLOGUE, BLEOMYCIN AND TRANSPORT PROTEIN) from Streptomyces verticillus (326 aa), FASTA scores: opt: 211, E(): 4.5e-06, (26.75% identity in 303 aa overlap); Q9X7M4|DDAH_STRCO|SC5F2A.01c NG,NG-dimethylarginine dimethylaminohydrolase (EC 3.5.3.18) (Dimethylargininase) (Dimethylarginine dimethylaminohydrolase) (258 aa), FASTA scores: opt: 209, E(): 4.9e-06, (27.15% identity in 243 aa overlap); G434715 beta-hydroxylase (bleomicin/phleomycin binding protein) from Streptomyces verticillus (326 aa), FASTA scores: opt: 211, E(): 4.5e-06, (26.75% identity in 303 aa overlap); etc.; hypothetical protein	complement(2595361..2596269)	Mycobacterium tuberculosis H37Rv	885480
NP_216840.1	CDS	Rv2324	NC_000962.2	2596334	2596780	D	Rv2324, (MTCY3G12.10), len: 148 aa. Probable transcriptional regulatory protein, asnC-family, similar to other PUTATIVE ASNC-FAMILY REGULATORY PROTEINS e.g. Q9L101|SCL6.15C from Streptomyces coelicolor (150 aa) FASTA scores: opt: 466, E(): 2.4e-24, (52.8% identity in 142 aa overlap); Q9RKY4|SC6D7.14 PUTATIVE ASNC-FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (165 aa), FASTA scores: opt: 266, E(): 5.5e-11, (32.4% identity in 145 aa overlap); Q9ZEP1|LRPA|SCE94.12c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (150 aa), FASTA scores: opt: 249, E(): 6.9e-10, (33.35% identity in 147 aa overlap); etc. Also similar to P96896|Rv3291c|MTCY71.31c from Mycobacterium tuberculosis (150 aa), FASTA scores: opt: 261, E(): 1.1e-10, (36.4% identity in 143 aa overlap).; AsnC family transcriptional regulator	2596334..2596780	Mycobacterium tuberculosis H37Rv	885060
NP_216841.1	CDS	Rv2325c	NC_000962.2	2597009	2597857	R	Rv2325c, (MTCY3G12.09), len: 282 aa. Conserved hypothetical protein, equivalent to O32970|MLCB22.37c|ML0849 hypothetical protein from Mycobacterium leprae (283 aa), FASTA scores: opt: 1405, E(): 1.8e-78, (77.7% identity in 282 aa overlap). Also some similarity to other proteins e.g. Q9Z9J1|YBAF|BH0166 YBAF PROTEIN (BH0166 PROTEIN) (HYPOTHETICAL PROTEIN) from Bacillus halodurans (265 aa), FASTA scores: opt: 288, E(): 2.8e-10, (25.8% identity in 264 aa overlap); P70972|YBAF YBAF PROTEIN (HYPOTHETICAL PROTEIN) from Bacillus subtilis (265 aa), FASTA scores: opt: 259, E(): 1.5e-08, (25.45% identity in 224 aa overlap); AAK34821|SPY2193|Q99X13 Conserved hypothetical protein from Streptococcus pyogenes (266 aa), FASTA scores: opt: 232, E(): 6.5e-07, (25.1% identity in 267 aa overlap); etc.; hypothetical protein	complement(2597009..2597857)	Mycobacterium tuberculosis H37Rv	886271
NP_216842.1	CDS	Rv2326c	NC_000962.2	2597854	2599947	R	Rv2326c, (MTC3G12.08), len: 697 aa. Possible transmembrane ATP-binding protein ABC transporter (see citation below). Equivalent to Q9CCF9|ML0848 ABC TRANSPORTER from Mycobacterium leprae (724 aa), FASTA scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap) and also to O32971|MLCB22.38c ABC-TYPE TRANSPORTER from Mycobacterium leprae (726 aa), FASTA scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap). Similar in part to other ABC TRANSPORTERS e.g. Q9WY65|TM0222 from Thermotoga maritima (266 aa), FASTA scores: opt: 407, E(): 4.2e-15, (38.0% identity in 213 aa overlap); etc. Contains 2 X PS00017 ATP/GTP-binding site motif A (P-loop); and 2 x PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; transmembrane ATP-binding protein ABC transorter	complement(2597854..2599947)	Mycobacterium tuberculosis H37Rv	888184
NP_216843.1	CDS	Rv2327	NC_000962.2	2599988	2600479	D	Rv2327, (MTCY3G12.07c), len: 163 aa. Conserved hypothetical protein, similar to Z80775|MTCY21D4.05c|Rv0042c from Mycobacterium tuberculosis (208 aa), FASTA scores: opt: 242, E(): 5e-08, (43.0% identity in 107 aa overlap). Also slight similarity to putative transcriptional regulatory proteins belonging to the MARR-FAMILY e.g. Q9CCY2/ML2696 from Mycobacterium leprae (243 aa), FASTA scores: opt: 245, E(): 3.7e-08, (35.35% identity in 150 aa overlap); Q9L135|SC6D11.20 from Streptomyces coelicolor (155 aa), FASTA scores: opt: 242, E(): 3.9e-08, (34.75% identity in 141 aa overlap); etc.; hypothetical protein	2599988..2600479	Mycobacterium tuberculosis H37Rv	888124
YP_177867.1	CDS	PE23	NC_000962.2	2600731	2601879	D	Rv2328, (MTCY3G12.06), len: 382 aa. Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS HOMOLOG from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc.; PE family protein	2600731..2601879	Mycobacterium tuberculosis H37Rv	888111
NP_216845.1	CDS	narK1	NC_000962.2	2601914	2603461	R	Rv2329c, (MTCY3G12.05), len: 515 aa. Probable narK1, nitrite extrusion protein, possibly member of major facilitator superfamily (MFS). Equivalent to O32974|MLCB22.41c|NARK|ML0844 PUTATIVE NITRITE EXTRUSION PROTEIN from Mycobacterium leprae (517 aa), FASTA scores: opt: 2224, E(): 1.9e-129, (69.3% identity in 488 aa overlap). Also highly similar to others e.g. P94933 NITRITE EXTRUSION PROTEIN from Mycobacterium fortuitum (471 aa), FASTA scores: opt: 1969, E(): 8.6e-114, (62.1% identity in 459 aa overlap); P37758|NARU_ECOLI NITRITE EXTRUSION PROTEIN 2 from Escherichia coli strain K12 (462 aa), FASTA scores: opt: 792, E(): 2.3e-41, (36.95% identity in 476 aa overlap); P10903|NARK_ECOLI nitrite extrusion protein (nitrite facilitator 1) from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 784, E(): 7e-41, (35.3% identity in 468 aa overlap); etc. Also similar to RV0261c|Z86089|MTCY6A4_5 from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 2000, E(): 1.1e-115, (62.6% identity in 470 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS.; nitrite extrusion protein 1 NarK1	complement(2601914..2603461)	Mycobacterium tuberculosis H37Rv	888116
NP_216846.1	CDS	lppP	NC_000962.2	2603695	2604222	R	Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP, lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LppP	complement(2603695..2604222)	Mycobacterium tuberculosis H37Rv	888072
NP_216847.1	CDS	Rv2331	NC_000962.2	2604297	2604683	D	Rv2331, (MT2393, MTCY3G12.03c), len: 128 aa. Hypothetical unknown protein; shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04.; hypothetical protein	2604297..2604683	Mycobacterium tuberculosis H37Rv	888099
YP_177669.1	CDS	Rv2331A	NC_000962.2	2604740	2605078	D	Rv2331A, len: 112 aa. Hypothetical unknown protein.; hypothetical protein	2604740..2605078	Mycobacterium tuberculosis H37Rv	3205048
NP_216848.2	CDS	mez	NC_000962.2	2605108	2606754	D	malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase	2605108..2606754	Mycobacterium tuberculosis H37Rv	887962
NP_216849.1	CDS	Rv2333c	NC_000962.2	2606708	2608321	R	Rv2333c, (MTCY3G12.01), len: 537 aa. Probable conserved integral membrane transport protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug, highly similar to many e.g. Q9RL22|C5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 1031, E(): 4e-55, (37.4% identity in 412 aa overlap); Q9L0L9|SCD82.12 PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (490 aa), FASTA scores: opt: 883, E(): 3.8e-46, (36.35% identity in 407 aa overlap); Q9ZBW5|SC4B5.03c PUTATIVE INTEGRAL MEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (504 aa), FASTA scores: opt: 899, E(): 4.1e-47, (37.4% identity in 415 aa overlap); P39886|TCMA_STRGA tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa), FASTA scores: opt: 839, E(): 1.9e-43, (32.3% identity in 489 aa overlap); etc. Also highly similar to Rv2459|O53186|MTV008.15 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (508 aa), FASTA scores: opt: 1385, E(): 1.5e-76, (44.05% identity in 504 aa overlap); and AAK46834|MT2534 DRUG TRANSPORTER from Mycobacterium tuberculosis strain CDC1551 (523 aa), FASTA scores: opt: 1385, E(): 1.5e-76, (44.4% identity in 504 aa overlap).; integral membrane transport protein	complement(2606708..2608321)	Mycobacterium tuberculosis H37Rv	887274
YP_177868.1	CDS	cysK1	NC_000962.2	2608796	2609728	D	Rv2334, (MT2397, MTCY98.03), len: 310 aa. Probable cysK1, cysteine synthase A (EC 4.2.99.8), equivalent to O32978|CYSK_MYCLE|ML0839|MLCB22.47 CYSTEINE SYNTHASE A from Mycobacterium leprae (310 aa), FASTA scores: opt: 1756, E(): 8.6e-96, (85.8% identity in 310 aa overlap). Also highly similar to other CYSTEINE SYNTHASES e.g. Q9JQL6|CYSK|NMA0974|NMB0763 PUTATIVE CYSTEINE SYNTHASE from Neisseria meningitidis (serogroup A and B) (310 aa), FASTA scores: opt: 1368, E(): 4.6e-73, (66.45% identity in 310 aa overlap); P73410|CYSK_SYNY3|SLR1842 from Synechocystis sp (312 aa), FASTA scores: opt: 1310, E(): 1.2e-69, (64.65% identity in 311 aa overlap); Q43725|CYSM_ARATH|OASC|ACS1|AT3G59760|F24G16.30 CYSTEINE SYNTHASE (MITOCHONDRIAL PRECURSOR) from Arabidopsis thaliana (Mouse-ear cress) (424 aa), FASTA scores: opt: 1253, E(): 3.2e-66, (59.2% identity in 309 aa overlap) (has its N-terminus longer 104 aa); etc. Contains PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. Note that previously known as cysK.; cysK; cysteine synthase A CysK1	2608796..2609728	Mycobacterium tuberculosis H37Rv	886016
NP_216851.1	CDS	cysE	NC_000962.2	2609732	2610421	D	Rv2335, (MTCY98.04), len: 229 aa. Probable cysE, serine acetyltransferase (EC 2.3.1.30), equivalent to O32979|CYSE|ML0838 SERINE ACETYLTRANSFERASE from Mycobacterium leprae (227 aa), FASTA scores: opt: 1152, E(): 9.6e-62, (76.4% identity in 229 aa overlap). Also highly similar, except in C-terminal part, to others e.g. Q9HXI6|CYSE|PA3816 O-ACETYLSERINE SYNTHASE from Pseudomonas aeruginosa (258 aa), FASTA scores: opt: 737, E(): 6e-37, (61.3% identity in 168 aa overlap); P23145|NIFP_AZOCH PROBABLE SERINE ACETYLTRANSFERASE from Azotobacter chroococcum mcd 1 (269 aa), FASTA scores: opt: 718, E(): 8.4e-36, (55.45% identity in 220 aa overlap); Q06750|CYSE_BACSU SERINE ACETYLTRANSFERASE from Bacillus subtilis (217 aa), FASTA scores: opt: 640, E(): 3.1e-31, (48.0% identity in 200 aa overlap); etc. Contains PS00101 Bacterial hexapeptide-repeat containing-transferases signature. BELONGS TO THE CYSE/LACA/LPXA/NODL FAMILY OF ACETYLTRANSFERASES. COMPOSED OF MULTIPLE REPEATS OF [LIV]-G-X(4).; serine acetyltransferase CysE	2609732..2610421	Mycobacterium tuberculosis H37Rv	886012
NP_216852.1	CDS	Rv2336	NC_000962.2	2610837	2611805	D	Rv2336, (MTCY98.05), len: 322 aa. Hypothetical unknown protein (see Rindi et al., 2001).; hypothetical protein	2610837..2611805	Mycobacterium tuberculosis H37Rv	888958
NP_216853.1	CDS	Rv2337c	NC_000962.2	2611869	2612987	R	Rv2337c, (MTCY98.06c), len: 372 aa. Hypothetical unknown protein, sharing some similarity with Q9RI33|SCJ12.27c HYPOTHETICAL 37.2 KDA PROTEIN from Streptomyces coelicolor (335 aa), BLAST scores: 134 AND 46, (28% AND 33% identity, 52% AND 44% positive); FASTA scores: opt: 176, E(): 0.00042, (31.95% identity in 355 aa overlap).; hypothetical protein	complement(2611869..2612987)	Mycobacterium tuberculosis H37Rv	885123
NP_216854.1	CDS	moeW	NC_000962.2	2613107	2614063	R	Rv2338c, (MTCY98.07c), len: 318 aa. Possible moeW, molybdoptenum biosynthesis protein, showing some similarity to several molybdopterin biosynthesis proteins e.g. O27613|MTH1571 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEB HOMOLOG from Methanobacterium thermoautotrophicum (251 aa), FASTA scores: opt: 309, E(): 4.7e-14; (30.7% identity in 254 aa overlap); Q9KPQ5|VC2311 HESA/MOEB/THIF FAMILY PROTEIN from Vibrio cholerae (273 aa), FASTA scores: opt: 255, E(): 4e-09, (36.25% identity in 149 aa overlap); Q9PD34|XF1545 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN from Xylella fastidiosa (276 aa), FASTA scores: opt: 233,E(): 1e-07, (33.6% identity in 128 aa overlap); etc. SEEMS TO BELONG TO THE HESA/MOEB/THIF FAMILY.; hypothetical protein	complement(2613107..2614063)	Mycobacterium tuberculosis H37Rv	886018
NP_216855.1	CDS	mmpL9	NC_000962.2	2614693	2617581	D	Rv2339, (MTCY98.08), len: 962 aa. Probable mmpL9, conserved transmembrane transport protein (see citation below), with strong similarity to other Mycobacterial proteins e.g. P54881|YV34_MYCLE|MML4_MYCLE hypothetical 105.2 kDa protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3799, E(): 0, (59.3% identity in 937 aa overlap); G699237|U1740AB from Mycobacterium leprae; and MTCY20G9.34; MTCY48.08c; MTCY19G5.06 from Mycobacterium tuberculosis. BELONGS TO THE MMPL FAMILY. TBparse score is 0.956.; transmembrane transport protein MmpL9	2614693..2617581	Mycobacterium tuberculosis H37Rv	888966
YP_177869.1	CDS	PE_PGRS39	NC_000962.2	2617667	2618908	R	Rv2340c, (MTCY98.09c), len: 413 aa. Member of the Mycobacterium tuberculosis PE_family, PGRS subfamily of gly-rich proteins (see citations below), similar to others eg YI18_MYCTU|Q50615|Rv1818c|MTCY1A11.25 PE-PGRS FAMILY PROTEIN from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 710, E(): 1.4e-22, (41.0% identity in 368 aa overlap); O53884|Rv0872v|MTV043.65c PGRS-FAMILY PROTEIN from Mycobacterium tuberculosis (606 aa), FASTA scores: opt: 708, E(): 1.9e-22, (42.4% identity in 389 aa overlap); etc.; PE-PGRS family protein	complement(2617667..2618908)	Mycobacterium tuberculosis H37Rv	888961
NP_216857.1	CDS	lppQ	NC_000962.2	2619597	2620016	D	Rv2341, (MTCY98.10), len: 139 aa. Probable lppQ, conserved lipoprotein, showing some similarity with Rv1228|O33224|LPQX|MTCI61.11 from Mycobacterium tuberculosis (185 aa), FASTA scores: opt: 155; E(): 0.0073; (31.9% identity in 116 aa overlap). Also shows few similarity with P29228|VLPA_MYCHR variant surface antigen A precursor from Mycoplasma hyorhinis (157 aa), FASTA scores: opt: 96, E(): 7.3, (23.1% identity in 143 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.929.; lipoprotein LppQ	2619597..2620016	Mycobacterium tuberculosis H37Rv	886275
NP_216858.1	CDS	Rv2342	NC_000962.2	2620272	2620529	D	Rv2342, (MTCY98.11), len: 85 aa. Conserved hypothetical protein, highly similar to Q9CCG1|ML0834 HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa), FASTA scores: opt: 392, E(): 2.9e-20, (78.2% identity in 78 aa overlap). N-terminus highly similar to N-terminal part of Q9L085|SCC24.32 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (108 aa), FASTA scores: opt: 122, E(): 0.077, (39.15% identity in 46 aa overlap). TBparse score is 0.887.; hypothetical protein	2620272..2620529	Mycobacterium tuberculosis H37Rv	888951
NP_216859.1	CDS	dnaG	NC_000962.2	2620533	2622452	R	synthesizes RNA primers at the replication forks; DNA primase	complement(2620533..2622452)	Mycobacterium tuberculosis H37Rv	885996
NP_216860.1	CDS	dgt	NC_000962.2	2622457	2623752	R	dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein	complement(2622457..2623752)	Mycobacterium tuberculosis H37Rv	885421
NP_216861.1	CDS	Rv2345	NC_000962.2	2623821	2625803	D	Rv2345, (MTCY98.14), len: 660 aa. Possible conserved transmembrane protein, with hydrophobic stretch at N-terminal end around position 180. Similar to O52198 HYPOTHETICAL 21.2 KDA PROTEIN (FRAGMENT) from Mycobacterium smegmatis (195 aa), FASTA scores: opt: 589, E(): 1.5e-23; (47.2% identity in 195 aa overlap). TBparse score is 0.895.; transmembrane protein	2623821..2625803	Mycobacterium tuberculosis H37Rv	888960
NP_216862.1	CDS	esxO	NC_000962.2	2625888	2626172	R	Rv2346c, (MT2411, MTCY98.15c), len: 94 aa. esxO, ESAT-6 like protein (see citation below), member of Mycobacterium tuberculosis protein family with O53942|Rv1793|MTV049.15, O05300|Rv1198|MTCI364.10, MTCY15C10.33, P96364|MTCY07H7B.03|Rv1037c|MTCY10G2.12, MTCI364.10, etc. BELONGS TO THE ESAT6 FAMILY.; ES6_6, Mtb9.9E; putative ESAT-6 like protein ESXO (ESAT-6 like protein 6)	complement(2625888..2626172)	Mycobacterium tuberculosis H37Rv	888956
NP_216863.1	CDS	esxP	NC_000962.2	2626223	2626519	R	Rv2347c, (MT2412, MTCY98.16c), len: 98 aa. esxP, ESAT-6 like protein (see citation below). Member of M. tuberculosis hypothetical QILSS protein family with Rv1197, Rv1792, Rv1038c and Rv3620c. BELONGS TO THE ESAT6 FAMILY. TBparse score is 0.896.; ES6_7, QILSS; putative ESAT-6 like protein ESXP (ESAT-6 like protein 7)	complement(2626223..2626519)	Mycobacterium tuberculosis H37Rv	886002
NP_216864.1	CDS	Rv2348c	NC_000962.2	2626654	2626980	R	Rv2348c, (MTCY98.17c), len: 108 aa. Hypothetical unknown protein.; hypothetical protein	complement(2626654..2626980)	Mycobacterium tuberculosis H37Rv	886006
NP_216865.1	CDS	plcC	NC_000962.2	2627172	2628698	R	Rv2349c, (MT2414, MTCY98.18c), len: 508 aa. Probable plcC, phospolipase C 3 (EC 3.1.4.3) (see citations below), similar to other precursors of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 NON-HEMOLYTIC PHOSPHOLIPASE C PRECURSOR from Pseudomonas aeruginosa (692 aa), FASTA scores: opt: 1013, E(): 9.3e-54, (38.85% identity in 525 aa overlap); P06200|PHLC_PSEAE HEMOLYTIC PHOSPHOLIPASE C PRECURSOR from Pseudomonas aeruginosa (730 aa), FASTA scores: opt: 630, E(): 1.5e-30, (35.15% identity in 535 aa overlap); Q9S816|T12J13.18|T21P5.4 PUTATIVE PHOSPHOLIPASE from Arabidopsis thaliana (Mouse-ear cress) (521 aa), FASTA scores: opt: 218, E(): 1e-05, (27.05% identity in 451 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C PHOSPHOLIPASE C 4 (514 aa), FASTA scores: opt: 2497, E(): 9e-144, (68.35% identity in 509 aa overlap); Q50560|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c PHOSPHOLIPASE C 1 (520 aa), FASTA scores: opt: 2494, E(): 1.4e-143, (68.1% identity in 514 aa overlap); P95246|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c PHOSPHOLIPASE C 2 (512 aa), FASTA scores: opt: 2474, E(): 2.2e-142, (67.65% identity in 513 aa overlap); etc. BELONGS TO THE BACTERIAL PHOSPHOLIPASE C FAMILY. TBparse score is 0.938.; phospholipase C 3 PLCC	complement(2627172..2628698)	Mycobacterium tuberculosis H37Rv	886000
NP_216866.1	CDS	plcB	NC_000962.2	2628781	2630319	R	Rv2350c, (MT2415, MTCY98.19c), len: 512 aa. Probable plcB (alternate gene name: mpcB), membrane-associated phospolipase C 2 (EC 3.1.4.3) (see citations below), similar to other precursors of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 NON-HEMOLYTIC PHOSPHOLIPASE C PRECURSOR from Pseudomonas aeruginosa (692 aa), FASTA scores: opt: 885, E(): 2.3e-44, (38.5% identity in 525 aa overlap); P06200|PHLC_PSEAE HEMOLYTIC PHOSPHOLIPASE C PRECURSOR from Pseudomonas aeruginosa (730 aa), FASTA scores: opt: 639, E(): 6.3e-30, (537 aa overlap); Q9RGS8 NON-HEMOLYTIC PHOSPHOLIPASE C from Pseudomonas aeruginosa (700 aa), FASTA scores: opt: 864, E(): 3.9e-43, (39.2% identity in 528 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q50560|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c PHOSPHOLIPASE C 1 (520 aa), FASTA scores: opt: 2788, E(): 4.5e-156, (75.5% identity in 514 aa overlap); Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C PHOSPHOLIPASE C 4 (514 aa), FASTA scores: opt: 2623, E(): 2.1e-146, (71.5% identity in 512 aa overlap); P95245|PLCC|Rv2349c|MT2414|MTCY98.18c PHOSPHOLIPASE C 3 (508 aa), FASTA scores: opt: 2474, E(): 1.1e-137, (67.65% identity in 513 aa overlap); etc. BELONGS TO THE BACTERIAL PHOSPHOLIPASE C FAMILY. SUPPOSED MEMBRANE-ASSOCIATED, AT THE EXTRACELLULAR SIDE. TBparse score is 0.931.; mpcB; membrane-associated phospholipase C	complement(2628781..2630319)	Mycobacterium tuberculosis H37Rv	885999
NP_216867.1	CDS	plcA	NC_000962.2	2630537	2632075	R	Rv2351c, (MTP40, MT2416, MTCY98.20c), len: 512 aa. Probable plcA (alternate gene name: mpcA), membrane-associated phospolipase C 1 (EC 3.1.4.3) (MTP40 antigen) (see citations below), similar to other precursors of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 NON-HEMOLYTIC PHOSPHOLIPASE C PRECURSOR from Pseudomonas aeruginosa (692 aa), FASTA scores: opt: 1064, E(): 4.3e-55, (39.85% identity in 517 aa overlap); P06200|PHLC_PSEAE HEMOLYTIC PHOSPHOLIPASE C PRECURSOR from Pseudomonas aeruginosa (730 aa), FASTA scores: opt: 562, E(): 1.6e-25, (35.35% identity in 481 aa overlap); Q9RGS8|PLCN|PHLN_BURPS NON-HEMOLYTIC PHOSPHOLIPASE C from Burkholderia pseudomallei (Pseudomonas pseudomallei) (700 aa), FASTA scores: opt: 843, E(): 4.4e-42, (40.5% identity in 531 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. P95246|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c PHOSPHOLIPASE C 2 (512 aa), FASTA scores: opt: 2788, E(): 1.2e-156, (75.5% identity in 514 aa overlap) (alias Q50561|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c PHOSPHOLIPASE C 2 (521 aa), FASTA scores: opt: 2700, E(): 1.8e-151, (73.8% identity in 515 aa overlap)); Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C PHOSPHOLIPASE C 4 (514 aa), FASTA scores: opt: 2643, E(): 4.1e-148, (71.6% identity in 511 aa overlap); etc. BELONGS TO THE BACTERIAL PHOSPHOLIPASE C FAMILY. SUPPOSED MEMBRANE-ASSOCIATED, AT THE EXTRACELLULAR SIDE.; mpcA; membrane-associated phospholipase C	complement(2630537..2632075)	Mycobacterium tuberculosis H37Rv	885995
YP_177870.1	CDS	PPE38	NC_000962.2	2632923	2634098	R	Rv2352c, (MTCY98.21c), len: 391 aa. Member of Mycobacterium tuberculosis PPE_family, highly similar to many e.g. Q10778|MTCY48.17|Y04H_MYCTU (734 aa), FASTA scores: opt: 713, E(): 2.8e-27, (37.7% identity in 430 aa overlap); Q10540|MTCY31.06c, Q11031|MTCY02B10.25c, Q10813|MTCY274.23c, P42611|MTV037.06C, P71868|MTCY03C7.23, P95248|MTCY98.22c, P71869|MTCY03C7.24c, etc.; PPE family protein	complement(2632923..2634098)	Mycobacterium tuberculosis H37Rv	888959
YP_177871.1	CDS	PPE39	NC_000962.2	2634528	2635592	R	Rv2353c, (MTCY98.22c), len: 354 aa. Member of Mycobacterium tuberculosis PPE family, highly similar to many e.g. near ORF P95249|Rv2356c|MTCY98.25 from Mycobacterium tuberculosis (615 aa), FASTA scores: opt: 1566, E(): 3.2e-69, (66.1% identity in 349 aa overlap); Q10778|MTCY48.17, Q10540|MTCY31.06c, E241779|MTCY98, Q10813|MTCY274.23c, P71868|MTCY03C7.23, P71869|MTCY03C7.24c, P42611|MTV037.06C, E64997|MTCY98, Q10707|MTCY49.38C, P71657|MTCY02B10.25c, etc. TBparse score is 0.932. Note that he ATG and RBS appear to be provided by the IR of neighbouring IS6110.; PPE family protein	complement(2634528..2635592)	Mycobacterium tuberculosis H37Rv	886003
NP_216870.1	CDS	Rv2354	NC_000962.2	2635628	2635954	D	Rv2354, (MTCY98.23), len: 108 aa. Probable IS6110 transposase, highly similar to others. - 1 frameshift required to complete translation. TBparse score is 0.928.; transposase	2635628..2635954	Mycobacterium tuberculosis H37Rv	888963
NP_216871.1	CDS	Rv2355	NC_000962.2	<2635951	2636889	D	Rv2355, (MTCY98.24), len: 312 aa. Probable IS6110 transposase, highly similar to others. TBparse score is 0.926.; transposase	<2635951..2636889	Mycobacterium tuberculosis H37Rv	888957
YP_177872.1	CDS	PPE40	NC_000962.2	2637688	2639535	R	Rv2356c, (MTCY98.25), len: 615 aa. Member of Mycobacterium tuberculosis PPE_family, highly similar to others e.g. Q10778|MTCY48.17|YF48_MYCTU HYPOTHETICAL PPE-FAMILY PROTEIN (678 aa), FASTA scores: opt: 1888, E(): 1.9e-78, (54.4% identity in 667 aa overlap); Q10540|MTCY31.06c, E241779|MTCY98, P42611|MTV037.06c, Q10813|MTCY274.23c, P71657|MTCY02B10.25c, MTCY03C7.23, P71869|MTCY03C7.24c, etc. TBparse score is 0.929.; PPE family protein	complement(2637688..2639535)	Mycobacterium tuberculosis H37Rv	888950
NP_216873.1	CDS	glyS	NC_000962.2	2639673	2641064	R	Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase	complement(2639673..2641064)	Mycobacterium tuberculosis H37Rv	888962
NP_216874.1	CDS	Rv2358	NC_000962.2	2641246	2641653	D	Rv2358, (MTCY27.22c), len: 135 aa. Probable transcriptional regulator, arsR family, equivalent to Q9CCG5|ML0825 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (140 aa), FASTA scores: opt: 647, E(): 2e-34, (72.9% identity in 140 aa overlap). Also similar to others e.g. BAB48273|MLR0745 Transcriptional regulator from Rhizobium loti (Mesorhizobium loti) (104 aa), FASTA scores: opt: 185, E(): 3.4e-05, (43.25% identity in 74 aa overlap) (has its N-terminus shorter); P15905|ARR1_ECOLI arsenical resistance operon repressor from Escherichia coli (117 aa), FASTA scores: opt: 164, E(): 8.1e-05, (39.1% identity in 69 aa overlap); etc. Also similar to O53838|Rv0827|MTV043.19c PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 201, E(): 4e-06, (35.7% identity in 98 aa overlap); and O69711|Rv3744|MTV025.092 PUTATIVE REGULATORY PROTEIN from Mycobacterium tuberculosis (120 aa), FASTA scores: opt: 209, E(): 1.2e-06, (35.5 % identity in 93 aa overlap). Contains possible helix-turn-helix motif at aa 72-93 (Score 1103, +2.94 SD). Belongs to the ARSR family of transciptional regulators.; ArsR family transcriptional regulator	2641246..2641653	Mycobacterium tuberculosis H37Rv	888965
NP_216875.1	CDS	furB	NC_000962.2	2641650	2642042	D	Rv2359, (MTCY27.21c), len: 130 aa. Probable furB, ferric uptake regulation protein, equivalent to FURB|ML0824|Q9CCG6 PUTATIVE FERRIC UPTAKE REGULATORY PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: opt: 765, E(): 1.7e-43, (86.9% identity in 130 aa overlap). Also highly similar to FERRIC UPTAKE REGULATION PROTEINS e.g. Q9L2H5|SCC121.11 PUTATIVE METAL UPTAKE REGULATION PROTEIN from Streptomyces coelicolor (139 aa), FASTA scores: opt: 547, E(): 3.4e-29, (59.4% identity in 133 aa overlap); P06975|FUR_ECOLI from Escherichia coli (148 aa), FASTA scores: opt: 322, E(): 1.9e-14, (37.9% identity in 132 aa overlap); P45599|FUR_KLEPN FERRIC UPTAKE REGULATION PROTEIN from Klebsiella pneumoniae (155 aa), FASTA scores: opt: 314, E(): 6.7e-14, (36.35% identity in 132 aa overlap); etc. BELONGS TO THE FUR FAMILY.; ferric uptake regulation protein FURB	2641650..2642042	Mycobacterium tuberculosis H37Rv	886009
NP_216876.1	CDS	Rv2360c	NC_000962.2	2642150	2642578	R	Rv2360c, (MTCY27.20), len: 142 aa. Hypothetical unknown protein.; hypothetical protein	complement(2642150..2642578)	Mycobacterium tuberculosis H37Rv	888952
NP_216877.1	CDS	Rv2361c	NC_000962.2	2642578	2643468	R	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase	complement(2642578..2643468)	Mycobacterium tuberculosis H37Rv	888964
NP_216878.1	CDS	recO	NC_000962.2	2643461	2644258	R	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO	complement(2643461..2644258)	Mycobacterium tuberculosis H37Rv	888954
NP_216879.1	CDS	amiA2	NC_000962.2	2644320	2645774	D	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase	2644320..2645774	Mycobacterium tuberculosis H37Rv	888955
YP_177873.1	CDS	era	NC_000962.2	2645771	2646673	R	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era	complement(2645771..2646673)	Mycobacterium tuberculosis H37Rv	886027
NP_216881.1	CDS	Rv2365c	NC_000962.2	2646747	2647088	R	Rv2365c, (MTCY27.15), len: 113 aa. Conserved hypothetical protein, highly similar to Q49767|ML0630|B1937_F3_101|CAC30138 Hypothetical protein from Mycobacterium leprae (108 aa), FASTA scores: opt: 426, E(): 1.4e-18, (67.9% identity in 106 aa overlap). Also highly similar to Q9RDF3|SCC77.05 from Streptomyces coelicolor (132 aa), FASTA scores: opt: 254, E(): 1.9e-18, (53.1% identity in 96 aa overlap). Equivalent to AAK46728 from Mycobacterium tuberculosis strain CDC1551 (93 aa) but longer 20 aa.; hypothetical protein	complement(2646747..2647088)	Mycobacterium tuberculosis H37Rv	885259
NP_216882.1	CDS	Rv2366c	NC_000962.2	2647060	2648367	R	Rv2366c, (MTCY27.14), len: 435 aa. Probable conserved transmembrane protein, highly similar to Q9L2L3|SCC117.07 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (358 aa), FASTA scores: opt: 1159, E(): 5.5e-64, (53.0% identity in 353 aa overlap); ans similar to hypothetical proteins and hemolysin-related proteins e.g. Q9HN02|HLP|VNG2308G HEMOLYSIN PROTEIN from Halobacterium sp. strain NRC-1 (457 aa), FASTA scores: opt: 623, E(): 6.2e-31, (28.4% identity in 433 aa overlap); etc. Potential transmembrane protein with 2 CBS domains. BELONGS TO THE UPF0053 FAMILY.; transmembrane protein	complement(2647060..2648367)	Mycobacterium tuberculosis H37Rv	885987
NP_216883.1	CDS	Rv2367c	NC_000962.2	2648364	2648912	R	Rv2367c, (MTCY27.13), len: 182 aa. Conserved hypothetical protein, equivalent to Q49752|YN67_MYCLE|ML0628|B1937_F1_21 HYPOTHETICAL 19.8 KDA PROTEIN from Mycobacterium leprae (178 aa), FASTA scores: opt: 1051, E(): 2e-59, (89.1% identity in 175 aa overlap). Also highly similar to others e.g. Q9L2L4|SCC117.06 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (165 aa), FASTA scores: opt: 599, E(): 6e-31, (56.5% identity in 154 aa overlap); Q9KD56|BH1363 HYPOTHETICAL PROTEIN from Bacillus halodurans (159 aa), FASTA scores: opt: 311, E(): 8.3e-13, (45.05% identity in 111 aa overlap); etc.; putative metalloprotease	complement(2648364..2648912)	Mycobacterium tuberculosis H37Rv	885989
YP_177874.1	CDS	phoH1	NC_000962.2	2648916	2649974	R	Rv2368c, (MTCY27.12), len: 352 aa. Probable phoH1, phoH-like protein (phosphate starvation-induced protein), probably ATP-binding protein, equivalent to Q49751|PHOL_MYCLE| ML0627|B1937_F1_20 PHOH-LIKE PROTEIN from Mycobacterium leprae (349 aa), FASTA scores: opt: 1952, E(): 4.7e-107, (88.9% identity in 352 aa overlap). Also highly similar to Q9L2L5|SCC117.05 PHOH-LIKE PROTEIN from Streptomyces coelicolor (359 aa), FASTA scores: opt: 1407, E(): 3.6e-75, (63.6% identity in 349 aa overlap); Q9RSY1|DR1988 PHOH-RELATED PROTEIN from Deinococcus radiodurans (380 aa), FASTA scores: opt: 1053, E(): 1.9e-54, (53.3% identity in 349 aa overlap); Q9KD58|PHOH|BH1361 PHOSPHATE STARVATION-INDUCED PROTEIN from Bacillus halodurans (320 aa), FASTA scores: opt: 1019, E(): 1.6e-52, (54.35% identity in 300 aa overlap); P46343|PHOL_BACSU PHOH-LIKE PROTEIN from Bacillus subtilis (319 aa), FASTA scores: opt: 1014, E(): 3.2e-52, (50.8% identity in 303 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE PHOH FAMILY. Note that previously known as phoH.; phoH; phosphate starvation-inducible protein PsiH	complement(2648916..2649974)	Mycobacterium tuberculosis H37Rv	885998
NP_216885.1	CDS	Rv2369c	NC_000962.2	2649946	2650248	R	Rv2369c, (MTCY27.11), len: 100 aa. Hypothetical unknown protein.; hypothetical protein	complement(2649946..2650248)	Mycobacterium tuberculosis H37Rv	885811
NP_216886.1	CDS	Rv2370c	NC_000962.2	2650245	2651558	R	Rv2370c, (MTCY27.10), len: 437 aa. Conserved hypothetical protein, member of family proteins from Mycobacterium tuberculosis with Rv1453|MTCY493_01c|O06807 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (432 aa), FASTA scores: opt: 1943, E(): 9.4e-115, (69.9% identity in 409 aa overlap); Rv1194c|MTCI364.06c; etc. Also similar to AAK45764|MT1500 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (432 aa), FASTA scores: opt: 1934, E(): 9.4e-115, (69.9% identity in 409 aa overlap).; hypothetical protein	complement(2650245..2651558)	Mycobacterium tuberculosis H37Rv	886017
YP_177875.1	CDS	PE_PGRS40	NC_000962.2	2651753	2651938	D	Rv2371, (MTCY27.09c), len: 61 aa. Short protein, member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to N-terminal part of others e.g. AAK44356|MT0132 PE_PGRS FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (561 aa), FASTA scores: opt: 217, E( ): 4.9e-08, (69.65% identity in 56 aa overlap); etc.; PE-PGRS family protein	2651753..2651938	Mycobacterium tuberculosis H37Rv	885141
NP_216888.1	CDS	Rv2372c	NC_000962.2	2652037	2652825	R	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE	complement(2652037..2652825)	Mycobacterium tuberculosis H37Rv	885926
NP_216889.1	CDS	dnaJ2	NC_000962.2	2652839	2653987	R	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ	complement(2652839..2653987)	Mycobacterium tuberculosis H37Rv	886023
NP_216890.1	CDS	hrcA	NC_000962.2	2654062	2655093	R	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor	complement(2654062..2655093)	Mycobacterium tuberculosis H37Rv	885924
NP_216891.1	CDS	Rv2375	NC_000962.2	2655265	2655582	D	Rv2375, (MTCY27.05c), len: 105 aa. Conserved hypothetical protein, highly similar to only CAC32314|2SCD60.09c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (98 aa), FASTA scores: opt: 425, E(): 5.7e-24, (63.25% identity in 98 aa overlap).; hypothetical protein	2655265..2655582	Mycobacterium tuberculosis H37Rv	885520
NP_216892.1	CDS	cfp2	NC_000962.2	2655609	2656115	R	Rv2376c, (MT2445, MTCY27.04), len: 168 aa. cfp2 (alternate gene name: mtb12), low molecular weight antigen, secreted protein similar to Q49771|MB12_MYCLE|ML0620|B1937_F3_91 LOW MOLECULAR WEIGHT ANTIGEN MTB12 HOMOLOG PRECURSOR from Mycobacterium leprae (167 aa), FASTA scores: opt: 682, E(): 1.7e-32, (65.5% identity in 165 aa overlap). BELONGS TO THE MTB12 FAMILY.; mtb12; low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2)	complement(2655609..2656115)	Mycobacterium tuberculosis H37Rv	885515
NP_216893.1	CDS	mbtH	NC_000962.2	2656215	2656430	R	Rv2377c, (MT2445.1, MTCY27.03), len: 71 aa. Putative mbtH, conserved protein with no function assigned (see Quadri et al ., 1998; De Voss et al., 1999), similar to hypothetical proteins or proteins found in several gene clusters for biosynthesis or transport of siderophores and other nonribosomally synthesized peptides e.g. Q9Z388|SCE8.11c PUTATIVE SMALL CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (71 aa), FASTA scores: opt: 345, E(): 1.4e-19, (68.2% identity in 66 aa overlap); Q9F8V3|CUMB COUY PROTEIN (probably involved in the biosynthesis of aminocoumarin antibiotic coumermycin A(1)) (see Wang et al., 2000) from Streptomyces rishiriensis (71 aa), FASTA scores: opt: 329, E(): 2.2e-18, (63.2% identity in 68 aa overlap); Q9F5J2|SIM-CB MBTH-LIKE PROTEIN (probably protein involved in the biosynthesis of aminocoumarin antibiotic coumermycin A(1)) from Streptomyces antibioticus (70 aa), FASTA scores: opt: 308, E(): 8.4e-17, (65.6% identity in 64 aa overlap); Q9FB14 MBTH-LIKE PROTEIN (involved in the biosynthesis of the antitumor drug bleomycin) (see Du et al., 2000) from Streptomyces verticillus FASTA scores: opt: 220, E(): 8.8e-10, (41.2% identity in 68 aa overlap); etc.; putative protein MbtH	complement(2656215..2656430)	Mycobacterium tuberculosis H37Rv	885968
NP_216894.1	CDS	mbtG	NC_000962.2	2656408	2657703	R	deleted EC_number 1.13.12.10; Rv2378c, (MTCY27.02), len: 431 aa. mbtG, lysine-N-oxygenase (hydroxylase) (EC 1.13.12.10 or 1.14.13.59; depending if enzyme is NADPH dependent or independent) (see citations below), showing some similarity with various proteins including ornithine and lysine-N-oxygenases, e.g. Q9K6Q1|TRKA|BH3677 POTASSIUM UPTAKE PROTEIN from Bacillus halodurans (350 aa), FASTA scores: opt: 153, E(): 0.016, (25.2% identity in 246 aa overlap); P56584|SID1_USTMA L-ORNITHINE 5-MONOOXYGENASE (EC 1.13.12.-) from Ustilago maydis (Smut fungus) (570 aa), FASTA scores: opt: 136, E(): 0.31, (22.85% identity in 127 aa overlap); Q9HHV0|HXYA|VNG6214G MONOOXYGENASE from Halobacterium sp. strain NRC-1 (477 aa), FASTA scores: opt: 119, E(): 3.4, (40.0% identity in 70 aa overlap); O69828|SC1A6.23 PUTATIVE LYSINE N-HYDROXLASE (FRAGMENT) from Streptomyces coelicolor (134 aa), BLAST score: 76 (similarity in part for this one); etc. COFACTORS: FAD (BY SIMILARITY).; lysine-N-oxygenase MBTG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase)	complement(2656408..2657703)	Mycobacterium tuberculosis H37Rv	885648
NP_216895.1	CDS	mbtF	NC_000962.2	2657700	2662085	R	Rv2379c, (MTCY27.01), len: 1461 aa. mbtF, peptide synthetase (see citations below), similar in part to several synthases e.g. O52820|PCZA363.4 PROTEIN from Amycolatopsis orientalis (4077 aa), FASTA scores: opt: 1873, E(): 1.1e-99, (35.55% identity in 1522 aa overlap); O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 aa), FASTA scores: opt: 1817, E(): 2.1e-96, (33.65% identity in 1463 aa overlap); O52821 PROTEIN SIMILAR TO PEPTIDE SYNTHETASE from Amycolatopsis orientalis (1860 aa) FASTA scores: opt: 1705, E(): 2.9e-90, (34.75% identity in 1344 aa overlap); Q9XCF2|PSTB PUTATIVE PEPTIDE SYNTHETASE (similar to Mycobacterium tuberculosis nrp protein) from Mycobacterium avium (2552 aa), FASTA scores: opt: 1687, E(): 4e-89, (35.45% identity in 1058 aa overlap); Q9ZET7 PEPTIDE SYNTHETASE (FRAGMENT) from Mycobacterium smegmatis (1438 aa), FASTA scores: opt: 1479, E(): 2.5e-77, (30.45% identity in 1507 aa overlap); etc. Contains PS00455 putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.; peptide synthetase MBTF (peptide synthase)	complement(2657700..2662085)	Mycobacterium tuberculosis H37Rv	885874
NP_216896.1	CDS	mbtE	NC_000962.2	2662067	2667115	R	Rv2380c, (MTCY22H8.05), len: 1682 aa. mbtE, peptide synthetase (see citations below), similar in part to several synthases e.g. O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 aa), FASTA scores: opt: 2635, E(): 1.9e-146, (36.8% identity in 1657 aa overlap); O05647|SNBDE VIRGINIAMYCIN S SYNTHETASE (FRAGMENT) from Streptomyces virginiae (1997 aa) FASTA scores: opt: 2580, E(): 1.6e-143, (40.65% identity in 1163 aa overlap); Q9R9I2|DHBF PROTEIN INVOLVED IN SIDEROPHORE PRODUCTION from Bacillus subtilis (2378 aa), FASTA scores: opt: 2388, E(): 3.6e-132, (33.9% identity in 1579 aa overlap); O68487|ACMB ACTINOMYCIN SYNTHETASE II from Streptomyces chrysomallus (2611 aa), FASTA scores: opt: 2165, E(): 4.9e-119, (35.0% identity in 1634 aa overlap); etc. Equivalent to AAK46743 from Mycobacterium tuberculosis strain CDC1551 (1787 aa) but shorter 105 aa. Contains PS00455 putative AMP-binding domain signature, and PS00012 Phosphopantetheine attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.; peptide synthetase MBTE (peptide synthase)	complement(2662067..2667115)	Mycobacterium tuberculosis H37Rv	885822
NP_216897.1	CDS	mbtD	NC_000962.2	2667255	2670269	R	Rv2381c, (MTCY22H8.04), len: 1004 aa. mbtD, polyketide synthase (see citations below), similar in part to several synthases e.g. Q03132|ERY2_SACER|ERYA ERYTHRONOLIDE SYNTHASE, MODULES 3 AND 4 (EC 2.3.1.94) from Saccharopolyspora erythraea (Streptomyces erythraeus) (3567 aa), FASTA scores: opt: 971, E(): 1e-46, (29.35% identity in 1043 aa overlap); Q9F829|MEGAII MEGALOMICIN 6-DEOXYERYTHRONOLIDE B SYNTHASE 2 from Micromonospora megalomicea subsp. nigra (3562 aa), FASTA scores: opt: 787, E(): 2.4e-36, (29.35% identity in 1032 aa overlap); Q9L4W4|NYSB POLYKETIDE SYNTHASE from Streptomyces noursei (3192 aa), FASTA scores: opt: 761, E(): 6.6e-35, (29.55% identity in 1086 aa overlap); O30764|NIDA1 POLYKETIDE SYNTHASE MODULES 1 AND 2 from Streptomyces caelestis (4340 aa), FASTA scores: opt: 726, E(): 7.8e-33, (27.3% identity in 1052 aa overlap); etc. Contains PS00012 Phosphopantetheine attachment site.; polyketide synthetase MBTD (polyketide synthase)	complement(2667255..2670269)	Mycobacterium tuberculosis H37Rv	885850
NP_216898.1	CDS	mbtC	NC_000962.2	2670269	2671603	R	Rv2382c, (MTCY22H8.03), len: 444 aa. mbtC, polyketide synthase (see citations below), similar in part to several synthases e.g. Q9F7T9 AVERMECTIN POLYKETIDE SYNTHASE (FRAGMENT) from Streptomyces avermitilis (3626 aa), FASTA scores: opt: 1458, E(): 7e-82, (50.65% identity in 446 aa overlap); AAG23264|SPNA POLYKETIDE SYNTHASE LOADING AND EXTENDER MODULE 1 from Saccharopolyspora spinosa (2595 aa) FASTA scores: opt: 1441, E(): 6e-81, (49.1% identity in 446 aa overlap); O33954|TYLG TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 from Streptomyces fradiae (4472 aa) FASTA scores: opt: 1439, E(): 1.2e-80, (51.0% identity in 447 aa overlap); O30764|NIDA1 POLYKETIDE SYNTHASE MODULES 1 AND 2 from Streptomyces caelestis (4340 aa) FASTA scores: opt: 1432, E(): 3.3e-80, (50.9% identity in 442 aa overlap); etc.; polyketide synthetase MBTC (polyketide synthase)	complement(2670269..2671603)	Mycobacterium tuberculosis H37Rv	885908
NP_216899.1	CDS	mbtB	NC_000962.2	2671593	2675837	R	Rv2383c, (MTCY22H8.02), len: 1414 aa. mbtB, phenyloxazoline synthase (see citations below), similar to the N-terminal region of several synthetases e.g. Q9EWP5|SC4C2.17 PUTATIVE NON-RIBOSOMAL PEPTIDE SYNTHASE from Streptomyces coelicolor (2229 aa), FASTA scores: opt: 2878, E(): 4.1e-156, (46.85% identity in 1138 aa overlap); Q9Z399|IRP2 YERSINIABACTIN BIOSYNTHETIC from Yersinia pestis (2041 aa), FASTA scores: opt: 2297, E(): 5.3e-123, (38.55% identity in 1069 aa overlap); P48633|HMP2_YEREN|IRP2 HIGH-MOLECULAR-WEIGHT PROTEIN 2 (MAY BE INVOLVED IN THE NONRIBOSOMAL SYNTHESIS OF SMALL PEPTIDES) from Yersinia enterocolitica (2035 aa), FASTA scores: opt: 2275, E(): 9.4e-122, (38.45% identity in 1069 aa overlap); O85739|PCHE|PA4226 DIHYDROAERUGINOIC ACID SYNTHETASE from Pseudomonas aeruginosa (1438 aa) FASTA scores: opt: 2236, E(): 1.2e-119, (38.2% identity in 1330 aa overlap); Q9RFM8|PCHE PYOCHELIN SYNTHETASE from Pseudomonas aeruginosa (1438 aa), FASTA scores: opt: 2229, E(): 3e-119, (38.0% identity in 1329 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature, and PS00012 Phosphopantetheine attachment site. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.; phenyloxazoline synthase MBTB (phenyloxazoline synthetase)	complement(2671593..2675837)	Mycobacterium tuberculosis H37Rv	885838
NP_216900.1	CDS	mbtA	NC_000962.2	2675936	2677633	D	Rv2384, (MTCY22H8.01, MTCY253.37c), len: 565 aa. mbtA, bifunctional enzyme, including salicyl-AMP ligase (Sal-AMP ligase) (EC 6.-.-.-) and salicyl-S-ArCP synthetase (see Quadri et al ., 1998; De Voss et al., 1999), highly similar to other ligases e.g. Q9F638|MXCE from Stigmatella aurantiaca 2,3-DHBA-AMP ligase (protein involved in the biosynthesis of 2,3-dihydroxybenzoic acid, contains the AMP binding signature) (543 aa), FASTA scores: opt: 1683, E(): 2.8e-90, (48.25% identity in 545 aa overlap) (see Silakowski et al., 2000); P40871|DHBE_BACSU|ENTE 2,3-DIHYDROXYBENZOATE-AMP LIGASE (EC 6.3.2.-) from Bacillus subtilis (539 aa), FASTA scores: opt: 1569, E(): 1.2e-83, (44.9% identity in 532 aa overlap); O07899|VIBE_VIBCHVC0772 VIBRIOBACTIN-SPECIFIC 2,3-DIHYDROXYBENZOATE-AMP LIGASE from Vibrio cholerae (543 aa), FASTA scores: opt: 1457, E(): 3.7e-77, (44.6% identity in 545 aa overlap); etc. Also similar to P95819|SNBA PRISTINAMYCIN I SYNTHETASE I from Streptomyces pristinaespiralis (582 aa), FASTA scores: opt: 1532, E(): 1.7e-81, (46.35% identity in 548 aa overlap); and Q9RFM9|PCHD SALICYL-AMP LIGASE from Pseudomonas aeruginosa (547 aa), FASTA scores: opt: 1415, E(): 1e-74, (45.95% identity in 533 aa overlap). Contains PS00455 Putative AMP-binding domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY.; bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase	2675936..2677633	Mycobacterium tuberculosis H37Rv	885833
YP_177876.1	CDS	mbtJ	NC_000962.2	2677729	2678649	D	Rv2385, (MTCY253.36c), len: 306 aa. Putative mbtJ, acetyl hydrolase (EC 3.1.1.-) (see citations below), showing some similarity with various hydrolases including acetyl hydrolases e.g. Q9ZBM4|MLCB1450.08|ML0314 PUTATIVE HYDROLASE/ESTERASE from Mycobacterium leprae (335 aa), FASTA scores: opt: 449, E(): 6.7e-21, (33.85% identity in 313 aa overlap); AAK47950|MT3591 Esterase from M. tuberculosis strain CDC1551 (327 aa), FASTA scores: opt: 469, E(): 3.6e-22, (35% identity in 283 aa overlap); Q9X8J4|SCE9.22 PUTATIVE ESTERASE from Streptomyces coelicolor (266 aa), FASTA scores: opt: 430,E(): 8.5e-20, (38% identity in 245 aa overlap); Q01109|BAH_STRHY ACETYL-HYDROLASE (EC 3.1.1.-) from Streptomyces hygroscopicus (299 aa), FASTA scores: opt: 420, E(): 4e-19, (35.1% identity in 265 aa overlap). Equivalent to AAK46748 from Mycobacterium tuberculosis strain CDC1551 (327 aa) but shorter 21 aa. Note that previously known as lipK.; lipK; putative acetyl hydrolase MBTJ	2677729..2678649	Mycobacterium tuberculosis H37Rv	885927
YP_177877.1	CDS	mbtI	NC_000962.2	2678653	2680005	R	catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function; salicylate synthase MbtI	complement(2678653..2680005)	Mycobacterium tuberculosis H37Rv	885823
NP_216903.1	CDS	Rv2387	NC_000962.2	2680765	2682018	D	Rv2387, (MTCY253.34c), len: 417 aa. Conserved hypothetical protein, showing some similarities with others e.g. Q9K663|BH3869 HYPOTHETICAL PROTEIN from Bacillus halodurans (337 aa), FASTA scores: opt: 343, E(): 4.8e-14, (29.0% identity in 400 aa overlap); AAK25471|CC3509 HYPOTHETICAL PROTEIN from Caulobacter crescentus (365 aa), FASTA scores: opt: 282, E(): 3.2e-10, (32.6% identity in 399 aa overlap); P73953|SLR1512 [D90911_21] CONSERVED HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC6803 (374 aa), FASTA scores: opt: 230, E(): 5.5e-07; (24.75% identity in 408 aa overlap); etc. Contains PS00213 Lipocalin signature.; hypothetical protein	2680765..2682018	Mycobacterium tuberculosis H37Rv	885302
NP_216904.1	CDS	hemN	NC_000962.2	2682015	2683142	R	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase	complement(2682015..2683142)	Mycobacterium tuberculosis H37Rv	885300
NP_216905.1	CDS	rpfD	NC_000962.2	2683248	2683712	R	Rv2389c, (MTCY253.32), len: 154 aa. Probable rpfD, resuscitation-promoting factor. Possible autocrine and/or paracrine bacterial growth factor or cytokine (see citation below). Similar to others from Mycobacterium tuberculosis e.g. O07747|Rv1884c|MTCY180.34|RPFC PROBABLE RESUSCITATION-PROMOTING FACTOR from Mycobacterium tuberculosis (176 aa), FASTA scores: opt: 382, E(): 2.3e-17, (55.45% identity in 101 aa overlap); etc. Also similarity with Q9CBF8|ML2030 HYPOTHETICAL PROTEIN from Mycobacterium leprae (157 aa), FASTA scores: opt: 397, E(): 2.4e-18, (47.95% identity in 121 aa overlap); Q9F2Q2|SCE41.06c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (244 aa), FASTA scores: opt: 341, E(): 1.1e-14, (40.45% identity in 131 aa overlap); and O86308|Z96935|MLRPF_1 RPF PROTEIN PRECURSOR from Micrococcus luteus (220 aa), FASTA scores: opt: 301, E(): 3.6e-12, (39.4% identity in 132 aa overlap). Contains a secretory signal sequence in N-terminus. Supposed acts at very low concentration.; resuscitation-promoting factor RpfD	complement(2683248..2683712)	Mycobacterium tuberculosis H37Rv	885246
NP_216906.1	CDS	Rv2390c	NC_000962.2	2683709	2684266	R	Rv2390c, (MTCY253.31), len: 185 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis proteins Q11032|YD62_MYCTU|MTCY02B10.26c|Rv1362c hypothetical 23.5 kDa protein (220 aa), FASTA scores: opt: 223, E(): 2.1e-07, (27.4% identity in 190 aa overlap); and Q11033|YD63_MYCTU|MTCY02B10.27c|Rv1363c hypothetical 28.3 kDa protein (261 aa), FASTA scores: opt: 238, E(): 2.7e-08, (27.6% identity in 163 aa overlap).; hypothetical protein	complement(2683709..2684266)	Mycobacterium tuberculosis H37Rv	885866
NP_216907.1	CDS	nirA	NC_000962.2	2684679	2686370	D	Rv2391, (MTCY253.30c), len: 563 aa. Probable nirA, ferredoxin-dependent nitrite reductase (EC 1.7.7.1), similar to many nitrite/nitrate reductases e.g. CAC33947|SCBAC1A6.26c Putative nitrite/sulphite reductase from Streptomyces coelicolor (565 aa), FASTA scores: opt: 2335, E(): 1.2e-137, (60.1% identity in 567 aa overlap); Q9RZD6|DRA0013 FERREDOXIN-NITRITE REDUCTASE from Deinococcus radiodurans (563 aa), FASTA scores: opt: 1141, E(): 2.2e-63, (39.6% identity in 533 aa overlap); Q59656|NIRA (D31732|PEENIRNRT_1) ferredoxin-dependent NITRITE REDUCTASE from Plectonema boryanum (654 aa) (see Suzuki & Kikuchi 1995), FASTA scores: opt: 805, E(): 1.9e-42, (31.7% identity in 517 aa overlap); Q55366|NIRA|SLR0898 FERREDOXIN-NITRITE REDUCTASE from Synechocystis sp. strain PCC 6803 (502 aa), FASTA scores: opt: 799, E(): 3.7e-42, (32.3% identity in 517 aa overlap); etc. Highly similar (only in N-terminal part because shortened protein (fragment) owing to an IS900 insertion) to Q9K541|NIRA NITRATE REDUCTASE (FRAGMENT) from Mycobacterium paratuberculosis (198 aa), FASTA scores: opt: 798, E(): 2.1e-42, (65.4% identity in 182 aa overlap) (see Bull et al., 2000).; ferredoxin-dependent nitrite reductase NIRA	2684679..2686370	Mycobacterium tuberculosis H37Rv	885472
NP_216908.1	CDS	cysH	NC_000962.2	2686367	2687131	D	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase	2686367..2687131	Mycobacterium tuberculosis H37Rv	885250
NP_216909.1	CDS	Rv2393	NC_000962.2	2687128	2687973	D	Rv2393, (MTCY253.28c), len: 281 aa. Conserved hypothetical protein, with some similarity to Q9L2E8|SC7A8.10c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (274 aa), FASTA scores: opt: 407, E(): 2.8e-18, (37% identity in 246 aa overlap); CAC38793|SCI39.05 Conserved hypothetical protein from Streptomyces coelicolor (305 aa), FASTA scores: opt: 394, E(): 2e-17, (35.0% identity in 251 aa overlap); AAK44492|MT0272 Chalcone/stilbene synthase family protein from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 350, E(): 9.2e-15, (34.0% identity in 235 aa overlap); P95216|Rv0259c|MTCY06A4.03c|Z86089 hypothetical protein from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 345, E(): 1.9e-14,(33.6% identity in 235 aa overlap).; hypothetical protein	2687128..2687973	Mycobacterium tuberculosis H37Rv	885508
NP_216910.1	CDS	ggtB	NC_000962.2	2688010	2689941	D	Rv2394, (MTCY253.27c), len: 643 aa. Probable ggtB, gamma-glutamyltranspeptidase precursor (EC 2.3.2.2), similar to many e.g. Q9KVF2|VC0194 from Vibrio cholerae (588 aa), FASTA scores: opt: 943, E(): 7.5e-47, (40.0% identity in 597 aa overlap); O69935|SC3C8.26 from Streptomyces coelicolor (603 aa), FASTA scores: opt: 822, E(): 7.2e-40, (33.6% identity in 622 aa overlap); P54422|GGT_BACSU from Bacillus subtilis (587 aa) FASTA scores: opt: 491, E(): 8.2e-21, (33.4% identity in 574 aa overlap); etc. Has potential signal peptide and appropriately positioned prokaryotic lipoprotein attachment site (PS00013).; gamma-glutamyltranspeptidase precursor GgtB	2688010..2689941	Mycobacterium tuberculosis H37Rv	885867
NP_216911.1	CDS	Rv2395	NC_000962.2	2690072	2692075	D	Rv2395, (MTCY253.26c), len: 667 aa. Probable conserved integral membrane protein, similar to AAK24613|CC2646 OLIGOPEPTIDE TRANSPORTER/OPT FAMILY PROTEIN from Caulobacter crescentus (666 aa), FASTA scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa overlap); Q9PIS5|CJ0204 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Campylobacter jejuni (665 aa), FASTA scores: opt: 1484, E(): 2.9e-77, (40.6% identity in 658 aa overlap); and P44016|Y561_HAEIN hypothetical integral membrane protein from Haemophilus influenzae (635 aa), FASTA scores: opt: 1449, E(): 2.8e-75, (42.15% identity in 624 aa overlap).; integral membrane protein	2690072..2692075	Mycobacterium tuberculosis H37Rv	885303
YP_177878.1	CDS	PE_PGRS41	NC_000962.2	2692799	2693884	D	Rv2396, (MTCY253.25c), len: 361 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to many e.g. AAK47132|MT2812 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1551 (454 aa), FASTA scores: opt: 1256, E(): 2.4e-44, (56.0% identity in 377 aa overlap); AAK46139|MT1866 PE_PGRS FAMILY PROTEIN from M. tuberculosis strain CDC1551 (491 aa), FASTA scores: opt: 1250, E(): 4.4e-44, (57.8% identity in 372 aa overlap); Y278_MYCTU|Rv0278C|MTV035.06c HYPOTHETICAL PE-PGRS FAMILY PROTEIN (957 aa), FASTA scores: opt: 1253, E(): 5.2e-44, (55.5% identity in 400 aa overlap); P71664|Rv1396c|MTCY21B4.13c HYPOTHETICAL GLYCINE-RICH 47.9 KDA PROTEIN (576 aa), FASTA scores: opt: 1236, E(): 1.8e-43, (55.55% identity in 402 aa overlap); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1.; PE-PGRS family protein	2692799..2693884	Mycobacterium tuberculosis H37Rv	885517
YP_177879.1	CDS	cysA1	NC_000962.2	2693909	2694964	R	Rv2397c, (MTCY253.24), len: 351 aa. Probable cysA1, sulfate-transport ATP-binding protein ABC transporter (see citations below), similar to OTHER SULFATE ABC TRANSPORTER ATP-BINDING PROTEINS e.g. P14788|CYSA_SYNP7 from Synechococcus sp. (344 aa), FASTA scores: opt: 1112, E(): 2.6e-56, (54.6% identity in 328 aa overlap); P74548|CYSA_SYNY3 from Synechocystis sp. (355 aa), FASTA scores: opt: 1063, E(): 1.7e-53, (51.9% identity in 343 aa overlap); Q9I6L0|CYSA|PA0280 from Pseudomonas aeruginosa (329 aa), FASTA scores: opt: 987, E(): 3.3e-49, (49.2% identity in 339 aa overlap); etc. Also similar to many ATP-binding proteins from Mycobacterium tuberculosis e.g. Rv2038c, Rv1238, Rv2832c, etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that previously known as cysA.; cysA; sulfate-transport ATP-binding protein ABC transporter CysA1	complement(2693909..2694964)	Mycobacterium tuberculosis H37Rv	885663
NP_216914.1	CDS	cysW	NC_000962.2	2694981	2695799	R	Rv2398c, (MTCY253.23), len: 272 aa. Probable cysW, sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. Q9K877|CYSW|BH3129 SULFATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (287 aa), FASTA scores: opt: 765, E(): 4.1e-40, (43.8% identity in 249 aa overlap); P27370|CYSW_SYNP7 sulfate transport system (permease) protein from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (286 aa), FASTA scores: opt: 757, E(): 1.3e-39, (44.3% identity in 264 aa overlap); Q9I6K9|CYSW|PA0281 SULFATE TRANSPORT PROTEIN from Pseudomonas aeruginosa (289 aa), FASTA scores: opt: 753, E(): 2.3e-39, (44.4% identity in 250 aa overlap); P16702|P76534|CYSW_ECOLI SULFATE TRANSPORT SYSTEM PERMEASE from Escherichia coli (291 aa), FASTA scores: opt: 633, E(): 5.7e-32, (38.2% identity in 267 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature. SIMILARITY WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS and BELONGS TO THE CYSTW SUBFAMILY.; sulfate-transport integral membrane protein ABC transporter CysW	complement(2694981..2695799)	Mycobacterium tuberculosis H37Rv	885305
NP_216915.1	CDS	cysT	NC_000962.2	2695796	2696647	R	Rv2399c, (MTCY253.22), len: 283 aa. Probable cysT, sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. BAB48989|MLR1667 PERMEASE PROTEIN OF SULFATE ABC TRANSPORTER from Rhizobium loti (283 aa), FASTA scores: opt: 756, E(): 7.9e-40, (40.95% identity in 271 aa overlap); Q9K878|CYST|BH3128 SULFATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (279 aa), FASTA scores: opt: 750, E(): 1.8e-39, (44.55% identity in 258 aa overlap); P16701|CYST_ECOLI|CYSU|CYST|B2424 from Escherichia coli (277 aa), FASTA scores: opt: 669, E(): 1.9e-34, (40.0% identity in 260 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CYSTW SUBFAMILY.; sulfate-transport integral membrane protein ABC transporter CysT	complement(2695796..2696647)	Mycobacterium tuberculosis H37Rv	885301
NP_216916.1	CDS	subI	NC_000962.2	2696644	2697714	R	Rv2400c, (MTCY253.21), len: 356 aa. Probable subI, sulfate-binding lipoprotein component of sulfate transport system (see citations below), equivalent to Q9CCN3|SUBI|ML0615 (alias Q49748|B1937_F1_11, 358 aa) PUTATIVE SULPHATE-BINDING PROTEIN from Mycobacterium leprae (348 aa), FASTA scores: opt: 1775, E(): 2.3e-102, (76.45% identity in 340 aa overlap). Also similar to others and other substrate-binding proteins e.g. P27366|SUBI_SYNP7|SBPA SULFATE-BINDING PROTEIN PRECURSOR from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (350 aa), FASTA scores: opt: 703, E(): 4.6e-36, (35.6% identity in 351 aa overlap); Q9I6K7|SBP|PA0283 SULFATE-BINDING PROTEIN PRECURSOR from Pseudomonas aeruginosa (332 aa), FASTA scores: opt: 591, E(): 3.7e-29, (36.9% identity in 317 aa overlap); CAC49112|SMB21133 PUTATIVE SULFATE UPTAKE ABC TRANSPORTER PERIPLASMIC SOLUTE-BINDING PROTEIN PRECURSOR from Rhizobium meliloti (Sinorhizobium meliloti) (341 aa), FASTA scores: opt: 569, E(): 8.8e-28, (36.15% identity in 321 aa overlap); etc. BELONGS TO THE PROKARYOTIC SULFATE BINDING PROTEIN FAMILY.; sulfate-binding lipoprotein	complement(2696644..2697714)	Mycobacterium tuberculosis H37Rv	885299
NP_216917.2	CDS	Rv2401	NC_000962.2	2697728	2698057	D	Rv2401, (MTCY253.19c), len: 109 aa. Hypothetical unknown protein. Equivalent to AAK46768 from Mycobacterium tuberculosis strain CDC1551 (134 aa) but shorter 25 aa. N-terminus extended since first submission (previously 72 aa).; hypothetical protein	2697728..2698057	Mycobacterium tuberculosis H37Rv	885664
YP_177670.1	CDS	Rv2401A	NC_000962.2	2698042	2698245	R	Rv2401A, len 67 aa. Possible conserved membrane protein, highly similar, but with 29 aa shorter, to ML0614|AL583919_34|Q49760 from Mycobacterium leprae (95 aa), FASTA scores: opt: 297, E(): 3.6e-15, (67.7% identity in 65 aa overlap). Has hydrophobic stretch.; hypothetical protein	complement(2698042..2698245)	Mycobacterium tuberculosis H37Rv	3205070
NP_216918.1	CDS	Rv2402	NC_000962.2	2698529	2700457	D	Rv2402, (MTCY253.18c), len: 642 aa. Conserved hypothetical protein, highly similar to others e.g. 9X8C4|SCE36.11c CONSERVED HYPOTHETICAL PROTEIN (FRAGMENT) from Streptomyces coelicolor (612 aa), FASTA scores: opt: 1283, E(): 6.5e-75, (41.9% identity in 623 aa overlap); Q9RJ38|SCI8.15 HYPOTHETICAL 66.3 KDA PROTEIN from Streptomyces coelicolor (595 aa), FASTA scores: opt: 1152, E(): 1.7e-66, (39.9% identity in 622 aa overlap), Q9S223|CI51.17 HYPOTHETICAL 68.4 KDA PROTEIN from Streptomyces coelicolor (612 aa), FASTA scores: opt: 1146, E(): 4.2e-66, (40.6% identity in 623 aa overlap); YAY3_SCHPO|Q10211|c4h3.03c HYPOTHETICAL 74.5 kDa PROTEIN from Schizosaccharomyces pombe (Fission yeast) (649 aa) FASTA scores: opt: 999, E(): 1.3e-56, (35.0% identity in 642 aa overlap); etc. Contains possible helix-turn-helix motif, at aa 224-245 (+4.68 SD).; hypothetical protein	2698529..2700457	Mycobacterium tuberculosis H37Rv	885661
NP_216919.1	CDS	lppR	NC_000962.2	2700535	2701290	R	Rv2403c, (MTCY253.17), len: 251 aa. Probable lppR, conserved lipoprotein, with weak similarity with MYCOBACTERIAL SERINE/THREONINE PROTEIN KINASES (EC 2.7.1.-) e.g. AAK45563|MT1304 from Mycobacterium tuberculosis strain CDC1551 (626 aa), FASTA scores: opt: 186, E(): 0.00023, (24.4% identity in 238 aa overlap), and the C-terminal part of Q11053|Rv1266c|MTCY50.16|PKNH_MYCTU from Mycobacterium tuberculosis (626 aa), FASTA scores: opt: 185, E()= 0.00027, (24.35% identity in 238 aa overlap). Has signal peptide and appropriate positioned prokaryotic lipoprotein attachment site (PS00013). Could belong to the SER/THR FAMILY of protein kinases.; lipoprotein LppR	complement(2700535..2701290)	Mycobacterium tuberculosis H37Rv	885513
NP_216920.1	CDS	lepA	NC_000962.2	2701287	2703248	R	binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA	complement(2701287..2703248)	Mycobacterium tuberculosis H37Rv	885475
NP_216921.1	CDS	Rv2405	NC_000962.2	2703269	2703838	D	Rv2405, (MTCY253.15c), len: 189 aa. Conserved hypothetical protein, identical (but N-terminus longer 40 residues) to AAK46773|MT2477 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551. Also highly similar, but N-terminus longer 38 residues, to Q9RD03|SCCM1.41 HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (154 aa), FASTA scores: opt: 451, E(): 2e-22, (48.7% identity in 154 aa overlap). Shows also similarity with hypothetical proteins from other species.; hypothetical protein	2703269..2703838	Mycobacterium tuberculosis H37Rv	885507
NP_216922.1	CDS	Rv2406c	NC_000962.2	2704009	2704437	R	Rv2406c, (MTCY253.14), len: 142 aa. Conserved hypothetical protein. C-terminal region is identical with many CBS DOMAIN PROTEIN e.g. AAK46774|MT2478 CBS DOMAIN PROTEIN from Mycobacterium tuberculosis strain CDC1551 (aa 47-142), FASTA scores: opt: 594, E(): 1.9e-30, (98.97% identity in 97 aa overlap); etc. Also similar to other hypothetical proteins e.g. AAK24594|CC2626 CBS DOMAIN PROTEIN from Caulobacter crescentus (157 aa), FASTA scores: opt: 377, E(): 8.3e-17, (42.55% identity in 141 aa overlap); BAB47826|MLR0188 from Rhizobium loti; etc.; hypothetical protein	complement(2704009..2704437)	Mycobacterium tuberculosis H37Rv	885156
NP_216923.1	CDS	Rv2407	NC_000962.2	2704697	2705518	D	member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z	2704697..2705518	Mycobacterium tuberculosis H37Rv	885684
YP_177880.1	CDS	PE24	NC_000962.2	2706017	2706736	D	Rv2408, (MTCY253.12c), len: 239 aa. Possibly a member of PE family (see citation below), similar to AAK46440|MT2159 from Mycobacterium tuberculosis strain CDC1551 (491 aa) FASTA scores: opt: 269, E(): 5.4e-08, (38.45% identity in 156 aa overlap) and AAK45466|MT1209 from Mycobacterium tuberculosis strain CDC1551 (308 aa), FASTA scores: opt: 265, E(): 6.3e-08, (36.0% identity in 197 aa overlap).; PE family protein	2706017..2706736	Mycobacterium tuberculosis H37Rv	885511
NP_216925.1	CDS	Rv2409c	NC_000962.2	2706494	2707333	R	Rv2409c, (MTCY253.11), len: 279 aa. Conserved hypothetical protein, equivalent to Q49757|YP69_MYCLE|G466976|B1937_F2_39 HYPOTHETICAL PROTEIN from Mycobacterium leprae (279 aa), FASTA scores: opt: 1564, E(): 4.6e-95, (82.1% identity in 279 aa overlap). Also similar to others e.g. Q9RSX6|DR1993 from Deinococcus radiodurans (274 aa), FASTA scores: opt: 494, E(): 4e-25, (35.1% identity in 282 aa overlap); BAB49898|Mll2875 from Rhizobium loti (Mesorhizobium loti) (294 aa), FASTA scores: opt: 382, E(): 8.9e-18, (29.75% identity in 269 aa overlap); Q9I305|PA1732 from Pseudomonas aeruginosa (266 aa), FASTA scores: opt: 326, E(): 3.7e-14, (31.25% identity in 275 aa overlap); etc. Also similar to Rv2569c|MTCY227.32 from Mycobacterium tuberculosis.; hypothetical protein	complement(2706494..2707333)	Mycobacterium tuberculosis H37Rv	885674
NP_216926.1	CDS	Rv2410c	NC_000962.2	2707333	2708310	R	Rv2410c, (MTCY253.10), len: 325 aa. Conserved hypothetical protein, equivalent to Q49770|CAC30114|ML0606 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (325 aa), FASTA scores: opt: 1928, E(): 3.5e-117, (90.75% identity in 325 aa overlap). Also some similarity with other hypothetical proteins e.g. Q9RST2|DR2041 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (316 aa), FASTA scores: opt: 329, E(): 5.3e-14, (32.4% identity in 318 aa overlap); C-terminus of Q9HUN7|PA4927 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (830 aa), FASTA scores: opt: 297, E(): 1.5e-11, (27.6% identity in 315 aa overlap); etc.; hypothetical protein	complement(2707333..2708310)	Mycobacterium tuberculosis H37Rv	885257
NP_216927.1	CDS	Rv2411c	NC_000962.2	2708310	2709965	R	Rv2411c, (MTCY253.09c), len: 551 aa. Hypothetical protein, highly similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 HYPOTHETICAL 61.8 KDA PROTEIN from Mycobacterium leprae (561 aa), FASTA scores, opt: 3163, E(): 4.1e-178, (87.35% identity in 554 aa overlap). Also highly similar, except in N-terminus, to others e.g. Q55587|Y335_SYNY3|SLL0335 HYPOTHETICAL PROTEIN from Synechocystis sp. strain PCC 6803 (481 aa), FASTA scores: opt: 1620, E(): 1.2e-87, (52.8% identity in 468 aa overlap); Q9I307|PA1730 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (470 aa), FASTA scores: opt: 1574, E(): 5.8e-85, (52.7% identity in 467 aa overlap); Q9RST1|DR2042 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (655 aa), FASTA scores: opt: 1561, E(): 4.4e-84, (53.3% identity in 467 aa overlap); etc.; hypothetical protein	complement(2708310..2709965)	Mycobacterium tuberculosis H37Rv	885681
NP_216928.1	CDS	rpsT	NC_000962.2	2710075	2710335	D	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20	2710075..2710335	Mycobacterium tuberculosis H37Rv	885676
NP_216929.1	CDS	Rv2413c	NC_000962.2	2710351	2711301	R	Rv2413c, (MTCY253.07), len: 316 aa. Conserved hypothetical protein, highly similar to O33133|MLCL536.07c|ML0603|Q49756|G466975|B1937_F2_36 hypothetical 39.1 KDA protein from Mycobacterium leprae (389 aa), FASTA scores: opt: 1683, E(): 1.8e-88, (83.9% identity in 316 aa overlap). ML0603 is a putative lipoprotein with an N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site that is not present in Rv2413c as this seems to be 73 aa shorter. Also some similarity with various proteins from other organisms e.g. Q9RDM2|SCC123.02c PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (336 aa), FASTA scores: opt: 792, E(): 6.1e-38, (42.4% identity in 316 aa overlap); Q9HX31|HOLA|PA3989 DNA POLYMERASE III, DELTA SUBUNIT from Pseudomonas aeruginosa (345 aa), FASTA scores: opt: 173, E(): 0.0084, (25.4% identity in 307 aa overlap); etc.; hypothetical protein	complement(2710351..2711301)	Mycobacterium tuberculosis H37Rv	885666
NP_216930.1	CDS	Rv2414c	NC_000962.2	2711332	2712876	R	Rv2414c, (MTCY253.06), len: 514 aa. Conserved hypothetical protein, showing some similarity with COME OPERON PROTEINS 3 (COMEC OR COME3) e.g. Q9RTB1|DR1854 PUTATIVE COMPETENCE PROTEIN COMEC/REC2 from Deinococcus radiodurans (755 aa), FASTA scores: opt: 311, E(): 8.2e-11, (27.3% identity in 538 aa overlap); P73100|COME|SLL1929 COME PROTEIN from Synechocystis sp. strain PCC 6803 (709 aa), FASTA scores: opt: 302, E(): 2.6e-10, (26.3% identity in 323 aa overlap) (no similarity on N-terminus); P39695|CME3_BACSU COME OPERON PROTEIN 3 from Bacillus subtilis (776 aa), FASTA scores: opt: 273, E(): 1.4e-08, (25.2% identity in 282 aa overlap) (no similarity on N-terminus); etc.; hypothetical protein	complement(2711332..2712876)	Mycobacterium tuberculosis H37Rv	885667
NP_216931.1	CDS	Rv2415c	NC_000962.2	2712891	2713784	R	Rv2415c, (MTCY253.05), len: 297 aa. Hypothetical protein, with some similarity in C-terminal part to comE operon proteins 1 e.g. Q9EU10|COME|COME4|COME1|COME2|COME3 COME PROTEIN (a competence protein with DNA-binding activity) from Neisseria gonorrhoeae (99 aa), FASTA scores: opt: 190, E(): 0.0032, (49.2% identity in 61 aa overlap); Q9JYB8|NMB1657 from Neisseria meningitidis (205 aa) FASTA scores: opt: 191, E(): 0.0052, (49.2% identity in 61 aa overlap); CME1_BACSU|P39694 come operon protein 1 from Bacillus subtilis (205 aa), FASTA scores, opt: 181, E(): 0.017 (29.8% identity in 218 aa overlap); etc.; hypothetical protein	complement(2712891..2713784)	Mycobacterium tuberculosis H37Rv	885697
NP_216932.2	CDS	eis	NC_000962.2	2714124	2715332	R	Rv2416c, (MTCY253.04), len: 402 aa. eis, enhanced intracellular survival gene (see citations below). Conserved hypothetical protein sharing similarity with Q9F309|SCC80.10 HYPOTHETICAL 44.7 KDA PROTEIN from Streptomyces coelicolor (413 aa), FASTA scores: opt: 382, E(): 1e-16, (31.45% identity in 407 aa overlap); Q9K4F4|SCD66.23 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (418 aa), FASTA scores: opt: 238, E(): 1.3e-07, (36.5% identity in 364 aa overlap): and Q54238|G1139577|ORF5 hypothetical protein from Streptomyces griseus (416 aa), FASTA scores: opt: 237, E(): 1.5e-07, (34.0 identity in 423 aa overlap). Start changed since first submission (- 6 aa) (see Dahl et al., 2001; Wei et al., 2000).; hypothetical protein	complement(2714124..2715332)	Mycobacterium tuberculosis H37Rv	885903
NP_216933.1	CDS	Rv2417c	NC_000962.2	2715472	2716314	R	Rv2417c, (MTCY253.03), len: 280 aa. Conserved hypothetical protein, highly similar to Q9RDL7|SCC123.07c HYPOTHETICAL 29.2 KDA PROTEIN from Streptomyces coelicolor (281 aa), FASTA scores: opt: 579, E(): 3.6e-27, (38.3% identity in 274 aa overlap). Also some similarity with DEGV proteins or hypothetical proteins from other organisms, e.g. Q9RSY3|DR1986 from Deinococcus radiodurans (281 aa), FASTA scores: opt: 393, E(): 3.4e-16, (31.0% identity in 280 aa overlap); P32436|DEGV_BACSU from Bacillus subtilis (281 aa), FASTA scores: opt: 365, E(): 1.5e-14, (27.8% identity in 284 aa overlap); BAB41937|BAB46307|SA0704|SAV0749 Conserved hypothetical protein from Staphylococcus aureus strain Mu50 and N315 (288 aa), FASTA scores: opt: 371, E(): 7e-15, (28.85% identity in 281 aa overlap); etc.; hypothetical protein	complement(2715472..2716314)	Mycobacterium tuberculosis H37Rv	885692
NP_216934.1	CDS	Rv2418c	NC_000962.2	2716395	2717138	R	Rv2418c, (MTCY253.02), len: 247 aa. Hypothetical unknown protein.; hypothetical protein	complement(2716395..2717138)	Mycobacterium tuberculosis H37Rv	885304
NP_216935.1	CDS	Rv2419c	NC_000962.2	2717128	2717799	R	Rv2419c, (MTCY428.28-MTCY253.01), len: 223 aa. Probable phosphoglycerate mutase (EC 5.4.2.1), equivalent to Q9CC00|ML1452 POSSIBLE PHOSPHOGLYCERATE MUTASE from Mycobacterium leprae (224 aa), FASTA scores: opt: 1206, E(): 8.8e-68, (80.35% identity in 224 aa overlap). Also highly similar to Q9RDL0|SCC123.14c PUTATIVE PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223 aa), FASTA scores: opt: 431, E(): 9.4e-20, (40.85% identity in 213 aa overlap); and similar to others e.g. Q9RVD2|DR1097 from Deinococcus radiodurans (232 aa), FASTA scores: opt: 291, E(): 4.6e-11, (39.3% identity in 173 aa overlap); etc. Some similarity to Q10512|Rv2228c|Y019_MYCTU|MT2287|MTcy427.09c hypothetical 39.2 kDa protein from Mycobacterium tuberculosis (364 aa) FASTA scores: opt: 196, E(): 2.8e-06, (45.6% identity in 79 aa overlap). Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature. BELONGS TO THE PHOSPHOGLYCERATE MUTASE FAMILY.; phosphoglycerate mutase (phosphoglyceromutase)	complement(2717128..2717799)	Mycobacterium tuberculosis H37Rv	885727
NP_216936.1	CDS	Rv2420c	NC_000962.2	2717796	2718176	R	Rv2420c, (MTCY428.27), len: 126 aa. Conserved hypothetical protein, equivalent to Q9CBZ9|ML1453 HYPOTHETICAL PROTEIN from Mycobacterium leprae (129 aa), FASTA scores: opt: 681, E(): 1.6e-38, (87.0% identity in 123 aa overlap). Also highly similar to Q9RDK9|SCC123.15c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (148 aa), FASTA scores: opt: 447, E(): 5.8e-23, (52.7% identity in 129 aa overlap); and similar to others e.g. P54457|YQEL_BACSU HYPOTHETICAL PROTEIN from Bacillus subtilis (118 aa), FASTA scores: opt: 318, E(): 1.8e-14, (37.3% identity in 110 aa overlap); Q9KD89|BH1328 HYPOTHETICAL PROTEIN from Bacillus halodurans (117 aa), FASTA scores: opt: 296, E(): 5.1e-13, (37.6% identity in 109 aa overlap); etc.; hypothetical protein	complement(2717796..2718176)	Mycobacterium tuberculosis H37Rv	885677
NP_216937.1	CDS	nadD	NC_000962.2	2718173	2718808	R	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase	complement(2718173..2718808)	Mycobacterium tuberculosis H37Rv	885457
NP_216938.1	CDS	Rv2422	NC_000962.2	2719083	2719355	D	Rv2422, (MTCY428.25c), len: 90 aa. Hypothetical unknown protein.; hypothetical protein	2719083..2719355	Mycobacterium tuberculosis H37Rv	885531
NP_216939.1	CDS	Rv2423	NC_000962.2	2719597	2720643	D	Rv2423, (MTCY428.24c), len: 348 aa. Hypothetical unknown protein.; hypothetical protein	2719597..2720643	Mycobacterium tuberculosis H37Rv	885516
NP_216940.1	CDS	Rv2424c	NC_000962.2	2720776	2721777	R	Rv2424c, (MTCY428.23), len: 333 aa. Probable transposase for IS1558, similar to IS element proteins e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 1491, E(): 6.2e-87, (98.6% identity in 221 aa overlap); P19780|YIS1_STRCO HYPOTHETICAL INSERTION ELEMENT IS110 from Streptomyces coelicolor (45 aa), FASTA scores: opt: 203, E(): 1.7e-05; (27.3% identity in 238 aa overlap); etc. Contains PS01159 WW/rsp5/WWP domain signature.; transposase	complement(2720776..2721777)	Mycobacterium tuberculosis H37Rv	885699
NP_216941.1	CDS	Rv2425c	NC_000962.2	2721866	2723308	R	Rv2425c, (MTCY428.22), len: 480 aa. Hypothetical protein; C-terminal half shares similarity to other unknown conserved proteins e.g. Q53065 HYPOTHETICAL 24.3 KDA PROTEIN from Rhodococcus erythropolis (219 aa), FASTA scores: opt: 398, E(): 9.9e-17, (34.15% identity in 202 aa overlap); C-terminus of O27843|MTH1815 CONSERVED PROTEIN from Methanothermobacter thermautotrophicus (346 aa), FASTA scores: opt: 341, E(): 3.7e-13, (31.35% identity in 233 aa overlap); etc.; hypothetical protein	complement(2721866..2723308)	Mycobacterium tuberculosis H37Rv	885673
NP_216942.1	CDS	Rv2426c	NC_000962.2	2723308	2724183	R	Rv2426c, (MTCY428.21), len: 291 aa. Conserved hypothetical protein, highly similar to others e.g. Q51326|ORF4 from Pseudomonas carboxydovorans (295 aa), FASTA scores: opt: 853, E(): 3.7e-43, (48.75% identity in 277 aa overlap); BAB47746|MLR0088 from Rhizobium loti (309 aa), FASTA scores: opt :809, E(): 1.5e-40, (46.5% identity in 291 aa overlap); Q9Y9R8|APE2220 from Aeropyrum pernix (297 aa), FASTA scores: opt: 763, E(): 7.4e-38, (47.1% identity in 261 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	complement(2723308..2724183)	Mycobacterium tuberculosis H37Rv	885909
NP_216943.1	CDS	proA	NC_000962.2	2724230	2725477	R	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase	complement(2724230..2725477)	Mycobacterium tuberculosis H37Rv	885536
NP_216944.1	CDS	ahpC	NC_000962.2	2726193	2726780	D	Rv2428, (MTCY428.18c), len: 195 aa. ahpC, alkyl hydroperoxide reductase C (EC 1.-.-.-) (see citations below), equivalent to other alkyl hydroperoxide reductases C mycobacterial proteins e.g. Q9CBF5|AHPC|ML2042 ALKYL HYDROPEROXIDE REDUCTASE from Mycobacterium leprae (195 aa) FASTA scores: opt: 1183, E(): 2.6e-72, (88.20% identity in 195 aa overlap); O87323|AHPC from Mycobacterium marinum (195 aa), FASTA scores: opt: 1215, E(): 1.9e-74, (90.8% identity in 195 aa overlap); Q57413|AHPC|AVI-3 from Mycobacterium avium (195 aa), FASTA scores: opt: 1201, E(): 1.6e-73, (90.25% identity in 195 aa overlap). Also highly similar to others from other organisms e.g. Q9FBP5|AHPC ALKYL HYDROPEROXIDE REDUCTASE from Streptomyces coelicolor (184 aa), FASTA scores: opt: 768, E(): 1.7e-44, (62.45% identity in 189 aa overlap); etc.; alkyl hydroperoxide reductase subunit C	2726193..2726780	Mycobacterium tuberculosis H37Rv	885717
NP_216945.1	CDS	ahpD	NC_000962.2	2726806	2727339	D	Rv2429, (MTCY428.17c), 177 aa. ahpD, alkyl hydroperoxide reductase (EC 1.-.-.-), similar to other alkyl hydroperoxide reductases D proteins e.g. Q9RN73|AHPD from Streptomyces coelicolor (178 aa), FASTA scores: opt: 611, E(): 1.4e-33, (57.4% identity in 169 aa overlap); Q50441|AHPD_MYCSM AHPD PROTEIN (FRAGMENT) from Mycobacterium smegmatis (52 aa), FASTA score: opt:196.; alkyl hydroperoxide reductase subunit D	2726806..2727339	Mycobacterium tuberculosis H37Rv	885959
YP_177881.1	CDS	PPE41	NC_000962.2	2727336	2727920	R	Rv2430c, (MTCY428.16), len: 194 aa. Member of the Mycobacterium tuberculosis PPE family similar to others e.g. AAK46014|Rv1745|MT1745 from Mycobacterium tuberculosis (385 aa) FASTA scores: opt: 389, E(): 1.2e-17, (35.95% identity in 192 aa overlap); etc.; PPE family protein	complement(2727336..2727920)	Mycobacterium tuberculosis H37Rv	885945
YP_177882.1	CDS	PE25	NC_000962.2	2727967	2728266	R	Rv2431c, (MTCY428.15), len: 99 aa. Member of the Mycobacterium tuberculosis PE family (see Brennan & Delogu 2002), similar to others e.g. AAK47158|MT2839 from Mycobacterium tuberculosis (275 aa) FASTA scores: opt: 194, E(): 2.5e-06, (40.0% identity in 95 aa overlap); etc.; PE family protein	complement(2727967..2728266)	Mycobacterium tuberculosis H37Rv	885703
NP_216948.1	CDS	Rv2432c	NC_000962.2	2728437	2728847	R	Rv2432c, (MTCY428.14), len: 140 aa. Hypothetical unknown protein.; hypothetical protein	complement(2728437..2728847)	Mycobacterium tuberculosis H37Rv	885075
NP_216949.1	CDS	Rv2433c	NC_000962.2	2728844	2729134	R	Rv2433c, (MTCY428.13), len: 96 aa. Hypothetical unknown protein.; hypothetical protein	complement(2728844..2729134)	Mycobacterium tuberculosis H37Rv	885579
NP_216950.1	CDS	Rv2434c	NC_000962.2	2729115	2730560	R	Rv2434c, (MTCY428.12), len: 481 aa. Probable conserved transmembrane protein, with some similarity to BAB48444|MLR0973 PROBABLE INTEGRAL MEMBRANE PROTEIN from Rhizobium loti (410 aa), FASTA scores: opt: 298, E(): 4.1e-11, (27.25% identity in 389 aa overlap); and also similarity with other hypothetical proteins and/or putative integral membrane proteins.; transmembrane protein	complement(2729115..2730560)	Mycobacterium tuberculosis H37Rv	885885
NP_216951.1	CDS	Rv2435c	NC_000962.2	2730557	2732749	R	Rv2435c, (MTCY428.11), len: 730 aa. Probable cyclase (adenylyl- or guanylyl-cyclase; EC 4.6.1.1 or 4.6.1.2 respectively); C-terminal domain (aa 500-730) similar to domain at C-terminus of a series of adenylate/guanylate cyclases (EC 4.6.-.-) e.g. O30820|CYA AAK45931|MT1661 from Mycobacterium tuberculosis (443 aa) FASTA scores: opt: 446, E(): 1.3e-19, (30.55% identity in 301 aa overlap); BAB50179|MLL3242 CYCLASE (ADENYLYL OR GUANYLYL) from Rhizobium loti (356 aa), FASTA scores: opt: 372, E(): 3.4e-15, (28.75% identity in 219 aa overlap); etc. BELONGS TO ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY.; cyclase	complement(2730557..2732749)	Mycobacterium tuberculosis H37Rv	885891
NP_216952.1	CDS	rbsK	NC_000962.2	2733230	2734144	D	Rv2436, (MTCY428.10c), len: 304 aa. Probable rbsK, ribokinase (EC 2.7.1.15), similar to others e.g. Q9RZ99|DRA0055 from Deinococcus radiodurans (300 aa) FASTA scores: opt: 485, E(): 9.1e-21, (44.55% identity in 301 aa overlap); P36945|P96733|RBSK_BACSU from Bacillus subtilis (293 aa), FASTA scores: opt: 398, E(): 8.5e-16, (36.35% identity in 297 aa overlap); P05054|RBSK_ECOLI|B3752|Z5253|ECS4694 from Escherichia coli strain K12 (309 aa), FASTA scores: opt: 387, E(): 3.8e-15, (34.7% identity in 314 aa overlap); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1. BELONGS TO THE PFKB FAMILY OF CARBOHYDRATE KINASES.; ribokinase RBSK	2733230..2734144	Mycobacterium tuberculosis H37Rv	885671
NP_216953.1	CDS	Rv2437	NC_000962.2	2734376	2734795	D	Rv2437, (MTCY428.09c), len: 139 aa. Conserved hypothetical protein, with some similarity to CONSERVED HYPOTHETICAL PROTEINS e.g. O06539|RV1139C|MTCI65.06c from Mycobacterium tuberculosis (166 aa); AAK45430|MT1172 from Mycobacterium tuberculosis (124 aa), FASTA scores: opt: 166, E(): 0.00013, (35.7% identity in 112 aa overlap); BAB48937|Mlr1600 from Rhizobium loti (222 aa), FASTA scores: opt: 163 ,E(): 0.00033, (28.1% identity in 121 aa overlap); etc.; hypothetical protein	2734376..2734795	Mycobacterium tuberculosis H37Rv	885906
NP_216954.2	CDS	nadE	NC_000962.2	2734792	2736831	R	catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase	complement(2734792..2736831)	Mycobacterium tuberculosis H37Rv	885808
YP_177671.1	CDS	Rv2438A	NC_000962.2	2736709	2736987	D	Rv2438A, len: 92 aa. Conserved hypothetical protein, showing few similarity with various enzymes e.g. part of O83441|VAA1_TREPA|ATPA1|TP0426 V-TYPE ATP SYNTHASE ALPHA CHAIN 1 (EC 3.6.1.34) from Treponema pallidum (589 aa), FASTA scores: opt: 110, E(): 1.5, (40.3% identity in 72 aa overlap); N-terminus of O95178|NIGM_HUMAN NADH-UBIQUINONE OXIDOREDUCTASE AGGG SUBUNIT PRECURSOR (EC 1.6.5.3) (EC 1.6.99.3) from Homo sapiens (105 aa), FASTA scores: opt: 109, E(): 1.5, (35.5% identity in 62 aa overlap); N-terminus of Q9HJ76|TA1096 PROBABLE GLYCEROL KINASE from Thermoplasma acidophilum (488 aa); etc.; hypothetical protein	2736709..2736987	Mycobacterium tuberculosis H37Rv	3205071
NP_216955.1	CDS	proB	NC_000962.2	2737117	2738247	R	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase	complement(2737117..2738247)	Mycobacterium tuberculosis H37Rv	885266
NP_216956.1	CDS	obgE	NC_000962.2	2738247	2739686	R	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE	complement(2738247..2739686)	Mycobacterium tuberculosis H37Rv	885900
NP_216957.1	CDS	rpmA	NC_000962.2	2739772	2740032	R	involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27	complement(2739772..2740032)	Mycobacterium tuberculosis H37Rv	885919
NP_216958.1	CDS	rplU	NC_000962.2	2740047	2740361	R	Rv2442c, (MTCY428.04), len: 104 aa. Probable rplU, 50S RIBOSOMAL PROTEIN L21, equivalent to Q9CBZ2|RL21_MYCLE from Mycobacterium leprae (103 aa), FASTA scores: opt: 579, E(): 4.8e-31, (91.1% identity in 102 aa overlap). Also highly similar to others e.g. P95756|RL21_STRGR from Streptomyces griseus (106 aa), FASTA scores: opt: 362, E(): 5.4e-17, (56.0% identity in 100 aa overlap); etc.; 50S ribosomal protein L21	complement(2740047..2740361)	Mycobacterium tuberculosis H37Rv	885715
NP_216959.1	CDS	dctA	NC_000962.2	2740709	2742184	D	Rv2443, (MTCY428.03c), len: 491 aa. Probable dctA, C4-dicarboxylate-transport transmembrane protein, similar to other C4-DICARBOXYLATE TRANSPORT PROTEINS e.g. AAK46817|MT2519 from Mycobacterium tuberculosis strain CDC1551 (491 aa); Q9L1K8|SC6A11.12 PUTATIVE SODIUM:DICARBOXYLATE SYMPORTER from Streptomyces coelicolor (466 aa), FASTA scores: opt: 1797, E(): 2.9e-98, (61.3% identity in 452 aa overlap); Q9RRG7|DR2525 from Deinococcus radiodurans (463 aa); P50334|DCTA_SALTY from Salmonella typhimurium (428 aa) FASTA scores: opt: 1241, E(): 1.3e-65, (47.2% identity in 415 aa overlap); etc. BELONGS TO THE SODIUM DICARBOXYLATE SYMPORTER FAMILY (SDF) (DAACS FAMILY).; C4-dicarboxylate-transport transmembrane protein DctA	2740709..2742184	Mycobacterium tuberculosis H37Rv	885745
NP_216960.1	CDS	rne	NC_000962.2	2742123	2744984	R	Rv2444c, (MTCY428.02), len: 953 aa. Possible rne, ribonuclease E (EC 3.1.-.-), highly similar to others e.g. Q9CBZ1|ML1468 POSSIBLE RIBONUCLEASE from Mycobacterium leprae (924 aa), FASTA scores: opt: 3713, E(): 2.4e-174, (74.2% identity in 966 aa overlap); Q9SI08|AT2G04270 PUTATIVE RIBONUCLEASE E from Arabidopsis thaliana (502 aa), FASTA scores: opt: 674, E(): 7.5e-26, (31.2% identity in 410 aa overlap); etc. Similar at C-terminal end to P21513|RNE_ECOLI|AMS|HMP1|B1084 ribonuclease E (EC 3.1.4.-) (RNASE E) from Escherichia coli strain K12 (1061 aa), FASTA scores: opt: 554, E(): 9.9e-20, (37.8% identity in 386 aa overlap). Also similar in medium part to several cytoplasmic axial filament proteins e.g. Q9HVU4|CAFA|PA4477 from Pseudomonas aeruginosa (485 aa), FASTA scores: opt: 664, E(): 2.3e-25, (42.8% identity in 418 aa overlap); etc. Equivalent to AAK46818 from Mycobacterium tuberculosis strain CDC1551 (621 aa) but longer 332 aa in N-terminal part. SEEMS TO BELONG TO THE RNE FAMILY.; ribonuclease E	complement(2742123..2744984)	Mycobacterium tuberculosis H37Rv	885911
NP_216961.1	CDS	ndk	NC_000962.2	2745314	2745724	R	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase	complement(2745314..2745724)	Mycobacterium tuberculosis H37Rv	885905
NP_216962.1	CDS	Rv2446c	NC_000962.2	2745767	2746138	R	Rv2446c, (MTV008.02c), len: 123 aa. Probable conserved integral membrane protein, highly similar to Q9CBY9|ML1470 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (123 aa), FASTA scores: opt: 468, E(): 6.7e-23, (66.65% identity in 108 aa overlap). Also similar to Q9L1G5|SCC88.24c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (118 aa), FASTA scores: opt: 130, E(): 0.13, (37.2% identity in 86 aa overlap); and some similarity to O06852|Y13070 hypothetical Streptomyces coelicolor gene also between fpgs and ndk genes (see citation below) (117 aa), FASTA scores: opt: 128, E(): 0.17, (36.0% identity in 86 aa overlap).; integral membrane protein	complement(2745767..2746138)	Mycobacterium tuberculosis H37Rv	885916
NP_216963.1	CDS	folC	NC_000962.2	2746135	2747598	R	Rv2447c, (MTV008.03c), len: 487 aa. Probable folC, folylpolyglutamate synthase (EC 6.3.2.17), equivalent to Q9CBY8|FOLC|ML1471 from Mycobacterium leprae (485 aa), FASTA scores: opt: 2425, E(): 2.2e-134, (78.7% identity in 483 aa overlap). Also highly similar to others e.g. Q9L1G4|FPGS|O08416|Y13070 from Streptomyces coelicolor (444 aa), FASTA scores: opt: 774, E(): 6.3e-38, (53.9% identity in 462 aa overlap); P15925|FOLC_LACCA|FGS from Lactobacillus casei (428 aa), FASTA scores: opt: 631, E(): 1.4e-29, (34.55% identity in 437 aa overlap); Q05865|FOLC_BACSU from Bacillus subtilis (430 aa), FASTA scores: opt: 421, E(): 2.6e-17, (32.9% identity in 383 aa overlap); etc. Contains PS01012 Folylpolyglutamate synthase signature 2. BELONGS TO THE FOLYLPOLYGLUTAMATE SYNTHASE FAMILY.; folylpolyglutamate synthase protein FolC	complement(2746135..2747598)	Mycobacterium tuberculosis H37Rv	885902
NP_216964.1	CDS	valS	NC_000962.2	2747595	2750225	R	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase	complement(2747595..2750225)	Mycobacterium tuberculosis H37Rv	885892
NP_216965.1	CDS	Rv2449c	NC_000962.2	2750313	2751572	R	Rv2449c, (MTV008.05c), len: 419 aa. Conserved hypothetical protein, highly similar to hypothetical proteins e.g. P95139|Rv2953|MTCY349.37c from M. tuberculosis (418 aa), FASTA scores: opt: 1829, E(): 4.7e-103, (67.3% identity in 419 aa overlap); AAK47353|MT3027 from Mycobacterium tuberculosis strain CDC1551 (418 aa), FASTA score: opt: 1829, E(): 4.7e-103, (67.3 identity in 419 aa overlap); Q9CD87|ML0129 from Mycobacterium leprae (418 aa), FASTA scores: opt: 1727, E(): 6.8e-97, (65.45% identity in 414 aa overlap); etc.; hypothetical protein	complement(2750313..2751572)	Mycobacterium tuberculosis H37Rv	885894
NP_216966.1	CDS	rpfE	NC_000962.2	2751662	2752180	R	Rv2450c, (MTV008.06c), len: 172 aa. Probable rpfE, resuscitation-promoting factor (see Mukamolova et al., 1998), similar to O86308|Z96935|MLRPF_1 RPF PROTEIN PRECURSOR from Micrococcus luteus (220 aa), FASTA scores: opt: 291, E(): 3e-7, (48.75% identity in 80 aa overlap). C-terminus is similar to other Mycobacterial rpf proteins e.g. O05594|Rv1009|MTCI237.26|RPFB PROBABLE RESUSCITATION-PROMOTING FACTOR from Mycobacterium tuberculosis (362 aa), FASTA scores: opt: 344, E(): 1.4e-09, (42.85% identity in 147 aa overlap); etc. C-terminal region similar to N-terminal region of Q9F2Q2|SCE41.06c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (244 aa), FASTA scores: opt: 355, E(): 3.1e-10, (56.65% identity in 90 aa overlap). Also similar to Q9F2Q1|SCE41.07c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (near Q9F2Q2|SCE41.06c) (341 aa) FASTA scores: opt: 317, E(): 2.5e-08, (51.7% identity in 87 aa overlap). With Mycobacterium leprae, high similarity between the two corresponding C-terminal regions of two HYPOTHETICAL PROTEINS, Q9CD53|ML0240 (375 aa), FASTA scores: opt: 339, E(): 2.5e-09, (59.15% identity in 93 aa overlap) and O33049|MLCB57.05c|ML2151 (174 aa), FASTA scores: opt: 329, E(): 4e-09, (58.14% identity in 86 aa overlap). Contains a possible secretory signal sequence in N-terminus. Possible autocrine and/or paracrine bacterial growth factor or cytokine (see citations below).; resuscitation-promoting factor RpfE	complement(2751662..2752180)	Mycobacterium tuberculosis H37Rv	885760
NP_216967.1	CDS	Rv2451	NC_000962.2	2752262	2752660	D	Rv2451, (MTV008.07), len: 132 aa. Hypothetical unknown pro-, ser-rich protein.; hypothetical protein	2752262..2752660	Mycobacterium tuberculosis H37Rv	886025
NP_216968.1	CDS	Rv2452c	NC_000962.2	2752848	2752994	R	Rv2452c, (MTV008.08c), len: 48 aa. Hypothetical unknown protein (see citation below).; hypothetical protein	complement(2752848..2752994)	Mycobacterium tuberculosis H37Rv	885858
NP_216969.1	CDS	mobA	NC_000962.2	2753018	2753623	R	MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A	complement(2753018..2753623)	Mycobacterium tuberculosis H37Rv	885904
NP_216970.1	CDS	Rv2454c	NC_000962.2	2753625	2754746	R	catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta	complement(2753625..2754746)	Mycobacterium tuberculosis H37Rv	887435
NP_216971.1	CDS	Rv2455c	NC_000962.2	2754743	2756704	R	Rv2455c, (MTV008.11c), len: 653 aa. Probable oxidoreductase, alpha subunit (EC 1.-.-.-), similar to others e.g. Q9F2W6|SCD20.13c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (645 aa), FASTA scores: opt: 2017, E(): 1e-111, (66.45% identity in 617 aa overlap) alias Q9RKS4|STAH10.35c PUTATIVE OXIDOREDUCTASE ALPHA-SUBUNIT from Streptomyces coelicolor (630 aa), FASTA scores: opt: 2008, E(): 3.4e-111, (66.45% identity in 614 aa overlap); Q9YA13|APE2126 LONG HYPOTHETICAL 2-OXOACID--FERREDOXIN OXIDOREDUCTASE ALPHA CHAIN from Aeropyrum pernix (644 aa) FASTA scores: opt: 687, E(): 4.6e-33, (33.35% identity in 441 aa overlap); etc. Note that the downstream ORF (MTV008.10c|Rv2454c) is possibly an oxidoreductase beta subunit.; oxidoreductase alpha subunit	complement(2754743..2756704)	Mycobacterium tuberculosis H37Rv	887370
NP_216972.1	CDS	Rv2456c	NC_000962.2	2756936	2758192	R	Rv2456c, (MTV008.12c), len: 418 aa. Probable conserved integral membrane transport protein, involved in a efflux system, weakly similar to many e.g. Q9RUR0|YD22_DEIRA|DR1322 PUTATIVE SUGAR EFFLUX TRANSPORTER from Deinococcus radiodurans (389 aa), FASTA scores: opt: 224, E(): 8.4e-06, (24.45% identity in 409 aa overlap); Q9UYY0|PAB0913 MULTIDRUG RESISTANCE PROTEIN from Pyrococcus abyssi (410 aa), FASTA scores: opt: 210, E(): 5.6e-05, (21.8% identity in 408 aa overlap); etc. Contains PS00216 Sugar transport proteins signature 1.; integral membrane transport protein	complement(2756936..2758192)	Mycobacterium tuberculosis H37Rv	887340
NP_216973.1	CDS	clpX	NC_000962.2	2758208	2759488	R	binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX	complement(2758208..2759488)	Mycobacterium tuberculosis H37Rv	888167
NP_216974.1	CDS	mmuM	NC_000962.2	2759779	2760687	D	converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; homocysteine methyltransferase	2759779..2760687	Mycobacterium tuberculosis H37Rv	885871
NP_216975.1	CDS	Rv2459	NC_000962.2	2760854	2762380	D	Rv2459, (MTV008.15), len: 508 aa. Probable conserved integral membrane transport protein, member of major facilitator superfamily (MFS) possibly involved in drug transport, highly similar to many efflux proteins e.g. Q9RL22|SC5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 788, E(): 1.3e-38, (34.45% identity in 412 aa overlap); Q9I428|PA1316 PROBABLE MFS TRANSPORTER from Pseudomonas aeruginosa (513 aa), FASTA scores: opt: 782, E(): 3.1e-38, (32.75% identity in 519 aa overlap); P39886|TCMA_STRGA tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa), FASTA scores: opt: 752, E(): 1.8e-36, (31.7% identity in 511 aa overlap); etc. Also highly similar to AAK46687|MT2395 DRUG TRANSPORTER from Mycobacterium tuberculosis strain CDC1551 (537 aa), FASTA scores: opt: 1396, E(): 5.6e-74, (44.45% identity in 504 aa overlap); and P71879|Rv2333c|MTCY3G12.01 PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis strain H37Rv (537 aa), FASTA scores: opt: 1385, E(): 2.5e-73, (44.25% identity in 504 aa overlap).; integral membrane transport protein	2760854..2762380	Mycobacterium tuberculosis H37Rv	888191
NP_216976.1	CDS	clpP2	NC_000962.2	2762531	2763175	R	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit	complement(2762531..2763175)	Mycobacterium tuberculosis H37Rv	888174
YP_177883.1	CDS	clpP	NC_000962.2	2763172	2763774	R	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit	complement(2763172..2763774)	Mycobacterium tuberculosis H37Rv	888176
NP_216978.1	CDS	tig	NC_000962.2	2763891	2765291	R	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor	complement(2763891..2765291)	Mycobacterium tuberculosis H37Rv	888615
NP_216979.1	CDS	lipP	NC_000962.2	2765655	2766839	D	Rv2463, (MTV008.19), len: 394 aa. Probable lipP, esterase (EC 3.1.-.-), lipase similar to others eg O87861|ESTA ESTERASE A from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 964, E(): 1.9e-53, (44.35% identity in 399 aa overlap); Q9I4S7|PA1047 PROBABLE ESTERASE from Pseudomonas aeruginosa (392 aa), FASTA scores: opt: 863, E(): 4.6e-47, (40.05% identity in 377 aa overlap); Q53403|ESTC ESTERASE III from Pseudomonas fluorescens (382 aa), FASTA scores: opt: 753, E(): 3.9e-40, (36.3% identity in 380 aa overlap); etc.; esterase/lipase LipP	2765655..2766839	Mycobacterium tuberculosis H37Rv	888572
NP_216980.1	CDS	Rv2464c	NC_000962.2	2766859	2767665	R	Rv2464c, (MT2539, MTV008.20c), len: 268 aa. Possible DNA glycosylase (EC 3.2.2.-), showing some similarity to several other DNA glycosylases e.g. Q9F308|SCC80.11c PUTATIVE DNA REPAIR HYDROLASE (FRAGMENT) from Streptomyces coelicolor (306 aa), FASTA scores: opt: 894, E(): 6.1e-51, (51.05% identity in 282 aa overlap); O50606|MUTM|FPG_THETH FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (EC 3.2.2.23) from Thermus aquaticus (267 aa), FASTA scores: opt: 342, E(): 4.6e-15, (32.4% identity in 250 aa overlap); Q9RCW5|SCM10.34c PUTATIVE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Streptomyces coelicolor (287 aa), FASTA scores: opt: 321, E(): 1.1e-13, (29.35% identity in 259 aa overlap); etc. Identical to AAK46839|MT2539 FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Mycobacterium tuberculosis strain CDC1551. Also similar to other Mycobacterium tuberculosis DNA glycosylases e.g. MTCY71.37 (32.9% identity in 277 aa overlap). BELONGS TO THE FPG FAMILY.; DNA glycosylase	complement(2766859..2767665)	Mycobacterium tuberculosis H37Rv	888500
YP_177884.1	CDS	Rv2465c	NC_000962.2	2767671	2768159	R	catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B	complement(2767671..2768159)	Mycobacterium tuberculosis H37Rv	887225
NP_216982.1	CDS	Rv2466c	NC_000962.2	2768261	2768884	R	Rv2466c, (MTV008.22c), len: 207 aa. Conserved hypothetical protein (see citation below), equivalent to Q9CBY0|ML1485 HYPOTHETICAL PROTEIN from Mycobacterium leprae (207 aa), FASTA scores: opt: 1154, E(): 1.1e-67, (80.6% identity in 206 aa overlap). Also highly similar to Q9L201|SC8E4A.04c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (216 aa), FASTA scores: opt: 789, E(): 4.6e-44, (57.9% identity in 213 aa overlap). Also similar to AAK46628|MT2344 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (230 aa), FASTA scores: opt: 324, E(): 6.1e-14, (30.4% identity in 194 aa overlap). Contains PS00195 Glutaredoxin active site.; hypothetical protein	complement(2768261..2768884)	Mycobacterium tuberculosis H37Rv	888214
YP_177885.1	CDS	pepN	NC_000962.2	2768986	2771571	D	Rv2467, (MTV008.23), len: 861 aa. Probable pepN, aminopeptidase N (EC 3.4.11.2), equivalent to Q9CBX9|ML1486 PROBABLE AMINOPEPTIDASE from Mycobacterium leprae (862 aa), FASTA scores: opt: 4751,E(): 0, (83.3% identity in 862 aa overlap). Also highly similar to others e.g. Q11010|AMPN_STRLI|PEPN from Streptomyces lividans (857 aa), FASTA scores: opt: 2839, E(): 1.8e-170, (53.25% identity in 864 aa overlap); Q9L1Z2|PEPN from Streptomyces coelicolor (857 aa), FASTA scores: opt: 2834, E(): 3.8e-170, (53.1% identity in 864 aa overlap); P37896|AMPN_LACDL|PEPN from Lactobacillus delbrueckii (subsp. lactis) (842 aa), FASTA scores: opt: 719, E(): 2.4e-37, (31.65% identity in 439 aa overlap); etc. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M1 (ZINC METALLOPROTEASE), ALSO KNOWN AS THE PEPN SUBFAMILY. Note that previously known as pepD.; pepD; aminopeptidase N	2768986..2771571	Mycobacterium tuberculosis H37Rv	887403
NP_216984.1	CDS	Rv2468c	NC_000962.2	2771644	2772147	R	Rv2468c, (MTV008.24c), len: 167 aa. Conserved hypothetical protein, highly similar to Mycobacterium leprae HYPOTHETICAL PROTEINS Q9CC58|ML1255 (163 aa), FASTA scores: opt: 859, E(): 1.6e-49, (81.2% identity in 165 aa overlap) and Q9X7B5|MLCB1610.16 (169 aa), FASTA scores: opt: 859, E(): 1.6e-49, (81.2% identity in 165 aa overlap). Also weak similarity with Q9X8D7|SCE39.14c PUTATIVE GNTR-FAMILY REGULATOR from Streptomyces coelicolor (243 aa), FASTA scores: opt: 116, E(): 1.3, (30.1% identity in 156 aa overlap).; hypothetical protein	complement(2771644..2772147)	Mycobacterium tuberculosis H37Rv	887767
NP_216985.1	CDS	Rv2469c	NC_000962.2	2772367	2773035	R	Rv2469c, (MTV008.25c), len: 222 aa. Conserved hypothetical protein, highly similar to other HYPOTHETICAL PROTEINS e.g. Q9X7B4|MLCB1610.15|ML1254 from Mycobacterium leprae (215 aa), FASTA scores: opt: 1183, E(): 3.3e-70, (77.9% identity in 222 aa overlap); Q9L1Y0|SC8E4A.25c from Streptomyces coelicolor (178 aa), FASTA scores: opt: 589, E(): 1.7e-31, (53.4% identity in 161 aa overlap) (N-terminal region is shorter 50 aa approximatively); Q9RRS6|DR2409 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (186 aa), FASTA scores: opt: 440, E(): 9.6e-22, (42.25% identity in 168 aa overlap) (N-terminal region is shorter 30 aa approximatively); etc.; hypothetical protein	complement(2772367..2773035)	Mycobacterium tuberculosis H37Rv	888591
NP_216986.1	CDS	glbO	NC_000962.2	2773178	2773564	D	Rv2470, (MTV008.26), len: 128 aa. Possible glbO, globin-like protein, highly similar to Q9CC59|GLBO|ML1253 HEMOGLOBIN-LIKE (OXYGEN CARRIER) from Mycobacterium leprae (128 aa), FASTA scores: opt: 767, E(): 4e-47, (88.1% identity in 126 aa overlap); Q9X7B3|MLCB1610.14c PUTATIVE GLOBIN from Mycobacterium leprae (131 aa); Q9L250|SC6D10.14 PUTATIVE GLOBIN from Streptomyces coelicolor (137 aa), FASTA scores: opt: 466, E(): 5.7e-26, (53.6% identity in 125 aa overlap). Also similar to O31607 YJBI PROTEIN from Bacillus subtilis (132 aa), FASTA scores: opt: 294, E(): 6.6e-14; (39.85% identity in 128 aa overlap). COULD BELONG TO PROTOZOAN/CYANOBACTERIAL GLOBIN FAMILY PROTEIN.; globin GlbO	2773178..2773564	Mycobacterium tuberculosis H37Rv	887743
NP_216987.1	CDS	aglA	NC_000962.2	2773564	2775204	D	Rv2471, (MTV008.27), len: 546 aa. Probable aglA, maltase (alpha-glucosidase) (EC 3.2.1.20), highly similar or similar to several e.g. Q60027|AGLA from Thermomonospora curvata (544 aa), FASTA scores: opt: 2071, E(): 4e-116, (57.7% identity in 525 aa overlap); Q9KZE3|AGLAE from Streptomyces coelicolor (534 aa), FASTA scores: opt: 1475, E(): 1.5e-80, (50.1% identity in 537 aa overlap); O86874|AGLA from Streptomyces lividans (534 aa), FASTA scores: opt: 1473, E(): 2e-80, (50.1% identity in 537 aa overlap); etc. SEEMS TO BELONG TO FAMILY 13 OF GLYCOSYL HYDROLASES, ALSO KNOWN AS THE ALPHA-AMYLASE FAMILY.; alpha-glucosidase AglA	2773564..2775204	Mycobacterium tuberculosis H37Rv	887393
NP_216988.1	CDS	Rv2472	NC_000962.2	2775272	2775565	D	Rv2472, (MTV008.28), len: 97 aa. Conserved hypothetical protein, showing some similarity to O53451|Rv1103c|MTV017.56c from Mycobacterium tuberculosis strain H37Rv (106 aa), FASTA scores: opt: 135, E(): 0.026, (45.85% identity in 72 aa overlap); and AAK45393|MT1135 HYPOTHETICAL 11.4 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (78 aa) FASTA scores: opt: 139, E(): 0.011, (45.35% identity in 75 aa overlap).; hypothetical protein	2775272..2775565	Mycobacterium tuberculosis H37Rv	887255
NP_216989.1	CDS	Rv2473	NC_000962.2	2775568	2776284	D	Rv2473, (MTV008.29), len: 238 aa. Possible pro-,ala-rich membrane protein, with possible transmembrane domain around aa 81-104.; alanine and proline rich membrane protein	2775568..2776284	Mycobacterium tuberculosis H37Rv	888163
NP_216990.1	CDS	Rv2474c	NC_000962.2	2776316	2776969	R	Rv2474c, (MTV008.30c), len: 217 aa. Hypothetical protein. Shows weak similarity with Q9L246|SC6D10.18c HYPOTHETICAL 24.9 KDA PROTEIN from Streptomyces coelicolor (238 aa), FASTA scores: opt: 111, E(): 5.6, (30% identity in 233 aa overlap), BLASTP scores: Score= 135, E= 3.5e-07, P= 3.5e-07, Identities= 55/182 (30%).; hypothetical protein	complement(2776316..2776969)	Mycobacterium tuberculosis H37Rv	888606
NP_216991.1	CDS	Rv2475c	NC_000962.2	2776975	2777391	R	Rv2475c, (MTV008.31c), len: 138 aa. Conserved hypothetical protein, showing similarity with Q9L245|SC6D10.19c HYPOTHETICAL 16.2 KDA PROTEIN from Streptomyces coelicolor (136 aa), FASTA scores: opt: 236, E(): 1.9e-09, (34.1% identity in 126 aa overlap). Also some similarity with AAK44393|Z97050|MTCI28_3 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis cosmid I (151 aa), FASTA scores: opt: 147, E(): 0.00025, (29.2% identity in 120 aa overlap).; hypothetical protein	complement(2776975..2777391)	Mycobacterium tuberculosis H37Rv	887793
NP_216992.1	CDS	gdh	NC_000962.2	2777388	2782262	R	Rv2476c, (MTV008.32c), len: 1624 aa. Probable gdh, glutamate dehydrogenase (EC 1.4.1.2). Highly similar to Q9X7B2|MLCB1610.10|ML1249 HYPOTHETICAL 177.9 KDA PROTEIN from Mycobacterium leprae (1622 aa), FASTA scores: opt: 8630,E(): 0, (81.45% identity in 1634 aa overlap). But highly similar to Q9F0J1|GDH NAD-GLUTAMATE DEHYDROGENASE from Streptomyces clavuligerus (1651 aa), FASTA scores: opt: 3833, E(): 0, (45.8% identity in 1600 aa overlap); (see Minambres et al., 2000). Also similar with others e.g. AAG53963|PA3068|GDHB HYPOTHETICAL (NAD(+)-DEPENDENT GLUTAMATE DEHYDROGENASE from Pseudomonas aeruginosa (1620 aa), FASTA scores: opt: 2214, E(): 1e-124, (40.1% identity in 1561 aa overlap) (see Lu & Abdelal 2001); and Q9Y8G5|GDHB NAD-SPECIFIC GLUTAMATE DEHYDROGENASE from Agaricus bisporus (1029 aa), FASTA scores: opt: 194, E(): 0.00099, (22.7% identity in 647 aa overlap) (see Kersten et al., 1999); etc. Contains possible Helix-turn-helix motif at aa 1568 to 1589 (score 1098, +2.93 SD).; NAD-dependent glutamate dehydrogenase	complement(2777388..2782262)	Mycobacterium tuberculosis H37Rv	887437
NP_216993.1	CDS	Rv2477c	NC_000962.2	2782366	2784042	R	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein	complement(2782366..2784042)	Mycobacterium tuberculosis H37Rv	887757
NP_216994.1	CDS	Rv2478c	NC_000962.2	2784123	2784608	R	Rv2478c, (MTV008.34c), len: 161 aa. Conserved hypothetical protein, with weak similarity with many single-strand binding proteins e.g. Q9X8U3|SCH24.29 PUTATIVE SINGLE-STRAND BINDING PROTEIN from Streptomyces coelicolor (199 aa), FASTA scores: opt: 246, E(): 4.5e-08, (31.5% identity in 162 aa overlap); P46390|SSB_MYCLE|ML2684|MLCB1913.20c SINGLE-STRAND BINDING PROTEIN (SSB) (HELIX-DESTABILIZING PROTEIN) from Mycobacterium leprae (168 aa), FASTA scores: opt: 239, E(): 1e-07, (30.8% identity in 146 aa overlap); P18310|SSBF_ECOLI SINGLE-STRAND BINDING PROTEIN from Escherichia coli (178 aa), FASTA scores: opt: 116, E(): 2.9, (25.7% identity in 140 aa overlap); etc. Also similarity with Rv0054|P71711|MTCY21D4.17|SSB_MYCTU PROBABLE SINGLE-STRAND BINDING PROTEIN from M. tuberculosis (164 aa), FASTA scores: opt: 234, E(): 2e-07, (31.75% identity in 148 aa overlap). N-terminus shorter 8 aa from AAK46855|MT2553 SINGLE-STRAND DNA BINDING PROTEIN from Mycobacterium tuberculosis strain CDC1551.; hypothetical protein	complement(2784123..2784608)	Mycobacterium tuberculosis H37Rv	887304
NP_216995.1	CDS	Rv2479c	NC_000962.2	2784657	>2785697	R	Rv2479c, (MTV008.35c), len: 346 aa. Probable transposase for IS6110, identical to many, probably translated by frame shifting from the upstream ORF.; transposase	complement(2784657..>2785697)	Mycobacterium tuberculosis H37Rv	887201
NP_216996.1	CDS	Rv2480c	NC_000962.2	2785592	2785918	R	Rv2480c, (MTV008.36c), len: 108 aa. Possible transposase for IS6110, identical to many.; transposase	complement(2785592..2785918)	Mycobacterium tuberculosis H37Rv	887328
NP_216997.1	CDS	Rv2481c	NC_000962.2	2786575	2786898	R	Rv2481c, (MTV008.37c), len: 107 aa. Hypothetical unknown protein.; hypothetical protein	complement(2786575..2786898)	Mycobacterium tuberculosis H37Rv	887462
NP_216998.1	CDS	plsB2	NC_000962.2	2786914	2789283	R	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase	complement(2786914..2789283)	Mycobacterium tuberculosis H37Rv	887848
NP_216999.1	CDS	plsC	NC_000962.2	2789280	2791022	R	Rv2483c, (MTV008.39c), len: 580 aa. Possible plsC, a transmembrane phospholipid biosynthesis bifunctionnal enzyme, including L-3-phosphoserine phosphatase (EC 3.1.3.3) and 1-acyl-Sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51), equivalent to Q9X7A9|PLSC|ML1245 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (579 aa), FASTA scores: opt: 2835, E(): 9.2e-153, (77.15% identity in 573 aa overlap). C-terminal end is similar to many 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASES (LYSOPHOSPHATIDIC ACIDACYLTRANSFERASES) e.g. Q9SDQ2 from Limnanthes floccosa (281 aa), FASTA scores: opt: 378, E(): 3.1e-14, (30.0% identity in 230 aa overlap) and Q42868|PLSC_LIMAL from Limnanthes alba (White meadowfoam) (281 aa), FASTA scores: opt: 374, E(): 5.2e-14, (30.55% identity in 221 aa overlap); and the N-terminal end is similar to many SERB FAMILY PROTEINS e.g. AAK44749|MT0526 from Mycobacterium tuberculosis strain CDC1551 (308 aa), FASTA scores: opt: 356, E(): 5.8e-13, (32.5% identity in 298 aa overlap) and Q49823|ML2424 from Mycobacterium leprae (300 aa), FASTA scores: opt: 346, E(): 2.1e-12, (32.0% identity in 278 aa overlap). So belongs to the 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE FAMILY and may belong to the SERB FAMILY.; bifunctionnal putative L-3-phosphoserine phosphatase/1-acyl-SN-glycerol-3-phosphate acyltransferase	complement(2789280..2791022)	Mycobacterium tuberculosis H37Rv	887744
NP_217000.1	CDS	Rv2484c	NC_000962.2	2791019	2792494	R	Rv2484c, (MTV008.40c), len: 491 aa. Conserved hypothetical protein, highly similar or similar to many Mycobacterial hypothetical proteins e.g. Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 2459, E(): 3e-138, (75.15% identity in 483 aa overlap); O53304|YU87_MYCTU|Rv3087|MTV013.08 from Mycobacterium tuberculosis (472 aa), FASTA scores: opt: 527, E(): 8.1e-24, (29.1% identity in 485 aa overlap); O53305|YU88_MYCTU|Rv3088|MT3173|MTV013.09 from Mycobacterium tuberculosis (474 aa), FASTA scores: opt: 370, E(): 1.6e-14, (26.05% identity in 422 aa overlap); etc.; hypothetical protein	complement(2791019..2792494)	Mycobacterium tuberculosis H37Rv	888623
NP_217001.1	CDS	lipQ	NC_000962.2	2792723	2793988	R	Rv2485c, (MTV008.41c), len: 421 aa. Probable lipQ, carboxylesterase protein (lipase) (EC 3.1.-.-). Similar (greater at the C-terminal end) to AAK46626|MT2342 PUTATIVE CARBOXYLESTERASE from Mycobacterium tuberculosis strain CDC1551 (431 aa), FASTA scores: opt: 1134, E(): 4.3e-60, (46.25% identity in 428 aa overlap); and Q50681|Rv2284|MTCY339.26c HYPOTHETICAL PROTEIN from M. tuberculosis strain H37Rv (431 aa), FASTA scores: opt: 1134, E(): 4.3e-60, (46.25% identity in 428 aa overlap). Also similar in part to other putative lipases/esterases e.g. AAK44451|MT0230 from Mycobacterium tuberculosis strain CDC1551 (403 aa), FASTA scores: opt: 763, E(): 4.6e-38, (37.95% identity in 390 aa overlap); Q9RY19|DR0133 from Deinococcus radiodurans (296 aa), FASTA scores: opt: 392, E(): 4e-16, (33.7% identity in 276 aa overlap); Q9Z545|SC9B2.14 from Streptomyces coelicolor (502 aa) FASTA scores: opt: 279, E(): 3.2e-09, (31.15% identity in 292 aa overlap); etc.; carboxylesterase LipQ	complement(2792723..2793988)	Mycobacterium tuberculosis H37Rv	887876
NP_217002.1	CDS	echA14	NC_000962.2	2794350	2795120	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	2794350..2795120	Mycobacterium tuberculosis H37Rv	887894
YP_177886.1	CDS	PE_PGRS42	NC_000962.2	2795301	2797385	R	Rv2487c, (MTV008.43c), len: 694 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins (see citation below), similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc.; PE-PGRS family protein	complement(2795301..2797385)	Mycobacterium tuberculosis H37Rv	887909
NP_217004.1	CDS	Rv2488c	NC_000962.2	2797467	2800880	R	Rv2488c, (MTV008.44c), len: 1137 aa. Probable transcriptional regulatory protein, belonging to luxR family, similar to many in Mycobacterium tuberculosis e.g. AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA scores: opt: 3767, E(): 1.8e-211, (56.75% identity in 1093 aa overlap); O53720|Rv0386|MTV036.21 from strain H37Rv (1085 aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75% identity in 1089 aa overlap); AAK45665|MT1402 from strain CDC1551 (1159 aa), FASTA scores: opt: 3395, E(): 8.2e-190, (52.0% identity in 1093 aa overlap); etc. Also similar to transcriptional regulatory proteins luxR-family from other organisms e.g. Q9CBP3|ML1753 from Mycobacterium leprae (1106 aa), FASTA scores: opt: 2823, E(): 1.5e-156, (50.35% identity in 1116 aa overlap); Q9KYF4|SCD72A.02 from Streptomyces coelicolor (1114 aa), FASTA scores: opt: 915, E(): 1.7e-45, (30.7% identity in 1143 aa overlap); etc. Some similarity with Q9KXP6|SC9C5.28 HYPOTHETICAL 81.8 KDA PROTEIN from Streptomyces coelicolor (750 aa), FASTA scores: opt: 1085, E(): 1.6e-55, (35.45% identity in 722 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial regulatory proteins, luxR family signature, probable coiled-coil from aa 585 to 616 and probable helix-turn-helix motif at aa 1086 to 1107 (score 1206, +3.29 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS.; LuxR family transcriptional regulator	complement(2797467..2800880)	Mycobacterium tuberculosis H37Rv	887997
NP_217005.1	CDS	Rv2489c	NC_000962.2	2800846	2801145	R	Rv2489c, (MTV008.45c), len: 99 aa. Hypothetical unknown ala-rich protein.; hypothetical protein	complement(2800846..2801145)	Mycobacterium tuberculosis H37Rv	888937
YP_177887.1	CDS	PE_PGRS43	NC_000962.2	2801254	2806236	R	Rv2490c, (MTV008.46c), len: 1660 aa. Member of the Mycobacterium tuberculosis PE family, PGRS-subfamily of Gly-rich proteins (see citation below), similar to many e.g. AAK47971|MT3612.1 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1551 (1715 aa), FASTA scores: opt: 5161, E(): 1.5e-187, (51.7% identity in 1752 aa overlap); etc.; PE-PGRS family protein	complement(2801254..2806236)	Mycobacterium tuberculosis H37Rv	887941
NP_217007.1	CDS	Rv2491	NC_000962.2	2806665	2807288	D	Rv2491, (MTV008.47), len: 207 aa. Conserved hypothetical protein, similar in part to other hypothetical proteins e.g. O29139|AF1126 from Archaeoglobus fulgidus (151 aa), FASTA scores: opt: 293, E(): 2.8e-11, (42.85% identity in 126 aa overlap); O66531|AQ_134 from Aquifex aeolicus (151 aa), FASTA scores: opt: 261, E(): 2.6e-09, (37.75% identity in 106 aa overlap); Q9HKU3|TA0501 from Thermoplasma acidophilum (161 aa), FASTA scores: opt: 260, E(): 3.2e-09, (35.9% identity in 117 aa overlap); etc.; hypothetical protein	2806665..2807288	Mycobacterium tuberculosis H37Rv	887780
NP_217008.1	CDS	Rv2492	NC_000962.2	2807278	2808030	D	Rv2492, (MTV008.48), len: 250 aa. Hypothetical unknown protein.; hypothetical protein	2807278..2808030	Mycobacterium tuberculosis H37Rv	887436
NP_217009.1	CDS	Rv2493	NC_000962.2	2808083	2808304	D	Rv2493, (MTV008.49), len: 73 aa. Conserved hypothetical protein, highly similar to AAK46916|MT2606 HYPOTHETICAL 8.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (74 aa), FASTA scores: opt: 234, E(): 4e-09, (56.95% identity in 74 aa overlap); and similar to O53373|Rv3321c|MTV016.21c HYPOTHETICAL 8.8 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (80 aa), FASTA scores: opt: 126, E(): 0.055, (30.75% identity in 78 aa overlap); and with weak similarity with other Mycobacterial hypothetical proteins e.g. Q9CCR7|ML0525 from Mycobacterium leprae (58 aa), FASTA scores: opt: 115, E(): 0.22, (47.75% identity in 44 aa overlap); etc.; hypothetical protein	2808083..2808304	Mycobacterium tuberculosis H37Rv	887480
NP_217010.1	CDS	Rv2494	NC_000962.2	2808310	2808735	D	Rv2494, (MTV008.50), len: 141 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P95023|EMBL:Z83863|MTCY159.26|Rv2530c (139 aa) FASTA scores: opt: 380 E(): 6.6e-19, (48.0% identity in 125 aa overlap); O53372|Rv3320c|MTV016.20c (142 aa), FASTA scores: opt: 287, E(): 1.3e-12, (41.6% identity in 125 aa overlap); AAK46915|MT2605 (strain CDC1551) (139 aa) FASTA scores: opt: 380, E(): 6.6e-19 (48.0% identity in 125 aa overlap); etc.; hypothetical protein	2808310..2808735	Mycobacterium tuberculosis H37Rv	887700
NP_217011.1	CDS	pdhC	NC_000962.2	2808758	2809939	R	Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA; branched-chain alpha-keto acid dehydrogenase subunit E2	complement(2808758..2809939)	Mycobacterium tuberculosis H37Rv	888237
NP_217012.1	CDS	pdhB	NC_000962.2	2809936	2810982	R	Rv2496c, (MTCY07A7.02c), len: 348 aa. Probable pdhB, pyruvate dehydrogenase e1 component, beta subunit (EC 1.2.4.1), similar to others e.g. Q9Y8I6||PDHB from Halobacterium volcanii (Haloferax volcanii) (327 aa) FASTA scores: opt: 1050, E(): 6.4e-60, (49.7% identity in 324 aa overlap); Q9KG98|BH0214 from Bacillus halodurans (328 aa), FASTA scores: opt: 987, E(): 6.9e-56, (45.7% identity in 324 aa overlap); Q9HN76|PDHB|VNG2218G from Halobacterium sp. strain NRC-1 (297 aa), FASTA scores: opt: 968, E(): 1.1e-54, (51.2% identity in 297 aa overlap); P21874|ODPB_BACST|PDHB PYRUVATE DEHYDROGENASE E1 COMPONENT from Bacillus stearothermophilus (324 aa), FASTA scores: opt: 951, E(): 1.4e-53, (47.6% identity in 321 aa overlap); etc. Also similar to Q9XA61|SCGD3.17c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1, BETA SUBUNIT (2-oxoisovalerate dehydrogenase) (EC 1.2.4.4) from Streptomyces coelicolor, (326 aa), FASTA scores: opt: 1178, E(): 4.1e-68, (55.0% identity in 322 aa overlap); Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1 BETA SUBUNIT from Streptomyces coelicolor (334 aa), FASTA scores: opt: 1173, E(): 8.8e-68, (55.6% identity in 320 aa overlap); Q53593|BKDB E1-BETA BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE from Streptomyces avermitilis (334 aa), FASTA scores: opt: 1132, E(): 3.7e-65, (55.0% identity in 320 aa overlap); etc.; pyruvate dehydrogenase E1 component beta subunit PdhB	complement(2809936..2810982)	Mycobacterium tuberculosis H37Rv	888571
NP_217013.1	CDS	pdhA	NC_000962.2	2810993	2812096	R	Rv2497c, (MTCY07A7.03c), len: 367 aa. Probable pdhA, pyruvate dehydrogenase e1 component, alpha subunit (EC 1.2.4.1), similar to many e.g. Q9Y8I5|PDHA from Halobacterium volcanii (Haloferax volcanii) (368 aa) FASTA scores: opt: 961, E(): 1.3e-52, (45.6% identity in 351 aa overlap); BAB40585 from Bacillus sp. UTB2301 (356 aa) FASTA scores: opt: 947, E(): 9.1e-52, (43.1% identity in 355 aa overlap); Q9KG99|BH0213 from Bacillus halodurans (367 aa), FASTA scores: opt: 896, E(): 1.4e-48, (42.65% identity in 340 aa overlap); etc. Also similar to several PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASES E1, BETA SUBUNIT (EC 1.2.4.4), alternate name : 2-oxoisovalerate dehydrogenase, e.g. Q53592|BKDA from Streptomyces avermitilis (381 aa), FASTA scores: opt: 980, E(): 8.5e-54, (45.65% identity in 370 aa overlap); etc.; pyruvate dehydrogenase E1 component alpha subunit PdhA	complement(2810993..2812096)	Mycobacterium tuberculosis H37Rv	888583
NP_217014.1	CDS	citE	NC_000962.2	2812355	2813176	R	Rv2498c, (MTCY07A7.04c), len: 273 aa. Probable citE, citrate lyase, beta subunit (EC 4.1.3.6), similar to others e.g. Q9S3L3|CITE from Corynebacterium glutamicum (Brevibacterium flavum) (217 aa), FASTA scores: opt: 565, E(): 1.5e-28, (41.85% identity in 215 aa overlap); Q9HRM8|CITE|VNG0627G from Halobacterium sp. strain NRC-1 (303 aa), FASTA scores: opt: 535, E(): 1.5e-26, (41.65% identity in 276 aa overlap); Q9S2U9|SC4G6.02 from Streptomyces coelicolor (274 aa), FASTA scores: opt: 426, E(): 1e-19, (37.6% identity in 274 aa overlap); P77770|CILB_ECOLI from Escherichia coli (307 aa), FASTA scores: opt: 265, E(): 1.5e-10, (32.8% identity in 265 aa overlap); etc. Also similar to Rv3075c|MTCY22D7.06 from Mycobacterium tuberculosis, FASTA score: (35.2% identity in 264 aa overlap).; citrate (Pro-3S)-lyase beta subunit	complement(2812355..2813176)	Mycobacterium tuberculosis H37Rv	887466
NP_217015.1	CDS	Rv2499c	NC_000962.2	2813173	2813730	R	Rv2499c, (MTCY07A7.05c), len: 185 aa. Possible oxidase regulatory-related protein, similar to many maoC MONOAMINE OXIDASE REGULATORY PROTEIN e.g. Q9RUZ1|DR1239 MAOC-RELATED PROTEIN from Deinococcus radiodurans (160 aa), FASTA scores: opt: 519, E(): 7.6e-28, (58.1% identity in 148 aa overlap); BAB48392|MLR0905 Probable monoamine oxidase regulatory protein from Rhizobium loti (Mesorhizobium loti) (150 aa), FASTA scores: opt: 480, E(): 2.9e-25, (49.0% identity in 149 aa overlap); Q9HN18|MAOC1|VNG2290G MONOAMINE OXIDASE REGULATORY-LIKE from Halobacterium sp. strain NRC-1 (208 aa), FASTA scores: opt: 419, E(): 4.6e-21, (45.6% identity in 158 aa overlap); P77455|MAOC_ECOLI|PAAZ|B1387 MaoC protein (Phenylacetic acid degradation protein paaZ) from Escherichia coli strain K12 (681 aa), FASTA scores: opt: 252, E(): 1.9e-09, (36.0% identity in 172 aa overlap); etc. But also similar to other proteins with different putative functions e.g. Q9HRM9|MAOC2|VNG0626G MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Halobacterium sp strain NRC-1 (157 aa), FASTA scores: opt: 380, E(): 1.5e-18, (45.75% identity in 153 aa overlap); Q9KIF1 FKBR2 from Streptomyces hygroscopicus var. ascomyceticus (175 aa), FASTA scores: opt: 355, E(): 7.6e-17, (42.0% identity in 150 aa overlap); CAC36828|Q99Q03|SAPE Spore associated protein from Streptomyces coelicolor (174 aa), FASTA scores: opt: 318, E(): 2.2e-14, (41.45% identity in 152 aa overlap); etc.; oxidase regulatory-like protein	complement(2813173..2813730)	Mycobacterium tuberculosis H37Rv	888584
NP_217016.1	CDS	fadE19	NC_000962.2	2813727	2814911	R	Rv2500c, (MTCY07A7.06c), len: 394 aa. Possible fadE19 (alternate gene name: , acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9XCG6|ACDH from Streptomyces coelicolor (386 aa), FASTA scores: opt: 1714, E(): 1.1e-98, (69.45% identity in 383 aa overlap); Q9XCG5|ACDH from Streptomyces avermitilis (386 aa), FASTA scores: opt: 1713, E(): 1.3e-98, (70.0% identity in 383 aa overlap); Q9L7W5|FENK from Bacillus subtilis (370 aa), FASTA scores: opt: 1094, E(): 2.3e-60, (48.4% identity in 372 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY.; mmgC; acyl-CoA dehydrogenase	complement(2813727..2814911)	Mycobacterium tuberculosis H37Rv	888541
NP_217017.1	CDS	accA1	NC_000962.2	2814916	2816880	R	Rv2501c, (MTCY07A7.07c, P46401), len: 654 aa. Probable accA1 (alternate gene name: bccA), acetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [INCLUDES: BIOTIN CARBOXYLASE (EC 6.3.4.14); BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)], similar to others eg Q9L076|FABG from Streptomyces coelicolor (646 aa), FASTA scores: opt: 2071, E(): 1e-113, (57.8% identity in 659 aa overlap); AAK24139|Q9A6C6|CC2168 from Caulobacter crescentus (654 aa), FASTA scores: opt: 1754, E(): 3.7e-95, (47.2% identity in 661 aa overlap); etc. Contains PS00188 Biotin-requiring enzymes attachment site, PS00866 Carbamoyl-phosphate synthase subdomain signature 1, and PS00867 Carbamoyl-phosphate synthase subdomain signature 2.; bccA; acetyl-/propionyl-coenzyme A carboxylase subunit alpha	complement(2814916..2816880)	Mycobacterium tuberculosis H37Rv	887309
NP_217018.1	CDS	accD1	NC_000962.2	2816885	2818474	R	Rv2502c, (MTCY07A7.08c), len: 529 aa. Probable accD1, acetyl-/propionyl-CoA carboxylase (beta subunit) (EC 6.4.1.-), similar, but with N-terminus shorter, to Q9L077|ACCD1 from Streptomyces coelicolor (538 aa), FASTA scores: opt: 2747, E(): 1.9e-159, (77.9% identity in 516 aa overlap). Also similar to others e.g. AAK24141|CC2170 from Caulobacter crescentus (530 aa), FASTA scores: opt: 2413, E(): 3.8e-139, (69.4% identity in 529 aa overlap); BAB54131|MLL7731 from Rhizobium loti (537 aa), FASTA scores: opt: 2399, E(): 2.7e-138, (67.4% identity in 527 aa overlap); etc. COULD BELONG TO THE ACCD/PCCB FAMILY.; acetyl-/propionyl-CoA carboxylase subunit beta	complement(2816885..2818474)	Mycobacterium tuberculosis H37Rv	887168
NP_217019.1	CDS	scoB	NC_000962.2	2818471	2819127	R	Rv2503c, (MTCY07A7.09c, MT2578), len: 218 aa. Probable scoB, 3-oxo acid:CoA transferase, beta subunit (succinyl-CoA:3-ketoacid-CoA transferase) (EC 2.8.3.5). Highly similar to others e.g. Q9XAM8|SC4C6.12c from Streptomyces coelicolor (217 aa), FASTA scores: opt: 1048, E(): 2.6e-60, (73.9% identity in 207 aa overlap); Q9XD82|PCAJ from Streptomyces sp. 2065 (214 aa), FASTA scores: opt: 1031, E(): 3.2e-59, (70.8% identity in 209 aa overlap); AAK53493|LPSJ from Xanthomonas campestris (pv. campestris) (212 aa), FASTA scores: opt: 886, E(): 6.6e-50, (62.5% identity in 208 aa overlap); P42316|SCOB_BACSU from Bacillus subtilis (216 aa), FASTA scores: opt: 820, E(): 1.2e-45, (58.2% identity in 201 aa overlap); etc. BELONGS TO THE 3-OXOACID COA-TRANSFERASE SUBUNIT B FAMILY.; succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta ScoB	complement(2818471..2819127)	Mycobacterium tuberculosis H37Rv	888502
NP_217020.1	CDS	scoA	NC_000962.2	2819124	2819870	R	Rv2504c, (MT2579, MTCY07A7.10c), len: 248 aa. Probable scoA, succinyl-CoA:3-ketoacid-Coenzyme A transferase, alpha subunit (3-oxo acid:CoA transferase) (EC 2.8.3.6). Highly similar to others e.g. Q9XAM7|SC4C6.13c from Streptomyces coelicolor (260 aa), FASTA scores: opt: 1130, E(): 2.2e-64, (69.9% identity in 249 aa overlap); Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa), FASTA scores: opt: 1121, E(): 8.1e-64, (69.5% identity in 249 aa overlap); etc. BELONGS TO THE 3-OXOACID COA-TRANSFERASE SUBUNIT A FAMILY.; succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha ScoA	complement(2819124..2819870)	Mycobacterium tuberculosis H37Rv	888503
NP_217021.1	CDS	fadD35	NC_000962.2	2819953	2821596	R	activates fatty acids by binding to coenzyme A; AMP-binding domain protein	complement(2819953..2821596)	Mycobacterium tuberculosis H37Rv	887774
NP_217022.1	CDS	Rv2506	NC_000962.2	2821712	2822359	D	Rv2506, (MTCY07A7.12), len: 215 aa. Probable transcriptional regulator, tetR family, similar to many others e.g. Q9L078|SCC105.06c PUTATIVE TETR-FAMILY REGULATORY PROTEIN from Streptomyces coelicolor (208 aa), FASTA scores: opt: 333, E(): 1.5e-14, (48.75% identity in 197 aa overlap); Q9X7X6|SC6A5.30c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (404 aa), FASTA scores: opt: 267, E(): 4.8e-10, (30.45% identity in 207 aa overlap) (similarity only with C-terminus for this one); Q9FBI8|SCP8.33c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (213 aa), FASTA scores: opt: 239, E(): 1.8e-08, (29.9% identity in 184 aa overlap); etc. Also similar to transcriptional regulatory proteins from Mycobacterium tuberculosis e.g. O05858|Rv3208|MTCY07D11.18c (228 aa), FASTA scores: opt: 218, E(): 4.4e-07, (30.35% identity in 191 aa overlap); C-terminus of P95251|Rv1963c|MTV051.01c|MTCY09F9.01 (406 aa), FASTA scores: opt: 238, E(): 3.6e-08, (28.25% identity in 177 aa overlap); P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt: 215, E(): 6.2e-07, (38.25% identity in 148 aa overlap); etc. Equivalent to AAK46885 from Mycobacterium tuberculosis strain CDC1551 (231 aa) but shorter 16 aa. Contains probable helix-turn-helix motif at aa 46-67, (Score 1660, +4.84 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.; TetR family transcriptional regulator	2821712..2822359	Mycobacterium tuberculosis H37Rv	888516
NP_217023.1	CDS	Rv2507	NC_000962.2	2822438	2823259	D	Rv2507, (MTCY07A7.13), len: 273 aa. Possible conserved pro-rich membrane protein (N-terminal half is Proline-rich), highly similar to Q9CCU3|ML0431 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (259 aa) (alias O07711|MLCL383.38c but longer 2 aa), FASTA scores: opt: 968, E(): 1.4e-31, (60.35% identity in 275 aa overlap). Contains potential membrane spanning region.; proline rich membrane protein	2822438..2823259	Mycobacterium tuberculosis H37Rv	888244
NP_217024.1	CDS	Rv2508c	NC_000962.2	2823256	2824593	R	Rv2508c, (MTCY07A7.14c), len: 445 aa. Probable conserved integral membrane leu-, ala-rich protein, equivalent to Q9CCU4|ML0430 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (454 aa) (alias O07710|MLCL383.37 longer 10 aa), FASTA scores: opt: 2205, E(): 2.5e-124, (75.75% identity in 441 aa overlap). Also similar to hypothetical or membrane proteins e.g. BAB50841|MLL4103 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (458 aa), FASTA scores: opt: 396, E(): 2.4e-16, (27.75% identity in 447 aa overlap); Q9RKX9|SC6D7.19c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (486 aa), FASTA scores: opt: 323, E(): 5.7e-12, (28.95% identity in 428 aa overlap); P42306|YXIO_BACSU PROBABLE INTEGRAL MEMBRANE PROTEIN from Bacillus subtilis (428 aa), FASTA scores: opt: 220, E(): 7.2e-06, (20.35% identity in 413 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Q10564|Y876_MYCTU|Rv0876c|MT0899|MTCY31.04c (548 aa), FASTA scores: opt: 184, E(): 0.0012, (24.7% identity in 466 aa overlap).; hypothetical protein	complement(2823256..2824593)	Mycobacterium tuberculosis H37Rv	888527
NP_217025.1	CDS	Rv2509	NC_000962.2	2824678	2825484	D	Rv2509, (MTCY07A7.15), len: 268 aa. Probable ala-rich oxidoreductase, short-chain dehydrogenase/reductase (EC 1.-.-.-), equivalent to O07709|MLCL383.36c|ML0429 DEHYDROGENASE (PUTATIVE OXIDOREDUCTASE) from Mycobacterium leprae (268 aa), FASTA scores: opt: 1509, E(): 2.6e-84, (88.75% identity in 267 aa overlap). Also highly similar to others e.g. O86553|SC1F2.16c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (276 aa), FASTA scores: opt: 492, E(): 9.5e-23, (38.15% identity in 262 aa overlap); Q9I5R3|PA0658 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (266 aa), FASTA scores: opt: 472, E(): 1.5e-21, (37.8% identity in 246 aa overlap); AAK22120|CC0133 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Caulobacter crescentus (266 aa), FASTA scores: opt: 428, E(): 6.9e-19, (35.8% identity in 243 aa overlap); etc. Also highly similar or similar to oxidoreductases from Mycobacterium tuberculosis e.g. Q10782|Rv1544|MTCY48.21 PUTATIVE KETOACYL REDUCTASE (EC 1.3.1.-) (267 aa), FASTA scores: opt: 656, E(): 1.1e-32, (43.05% identity in 267 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short-chain type dehydrogenase/reductase	2824678..2825484	Mycobacterium tuberculosis H37Rv	888526
NP_217026.1	CDS	Rv2510c	NC_000962.2	2825488	2827089	R	Rv2510c, (MTCY07A7.16c), len: 533 aa. Hypothetical unknown protein, highly similar, but longer approximatively 20 aa, to others e.g. Q9ABY0|CC0090 HYPOTHETICAL PROTEIN from Caulobacter crescentus (516 aa), FASTA scores: opt: 1282, E(): 8.4e-63, (45.1% identity in 490 aa overlap); Q9A130|SPY0500 HYPOTHETICAL PROTEIN from Streptococcus pyogenes (500 aa), FASTA scores: opt: 1281, E(): 9.3e-63, (43.8% identity in 491 aa overlap); Q985L5|MLR7622 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (515 aa), FASTA scores: opt: 1259, E(): 1.5e-61, (44.1% identity in 510 aa overlap); P39342|YJGR_ECOLI|B4263 HYPOTHETICAL 54.3 KDA PROTEIN from Escherichia coli strain K12 (500 aa), FASTA scores: opt: 1257, E(): 1.9e-61, (42.7% identity in 501 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	complement(2825488..2827089)	Mycobacterium tuberculosis H37Rv	888613
NP_217027.1	CDS	orn	NC_000962.2	2827157	2827804	D	3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease	2827157..2827804	Mycobacterium tuberculosis H37Rv	888633
NP_217028.1	CDS	Rv2512c	NC_000962.2	2828556	2829803	R	Rv2512c, (MTCY07A7.18c), len: 415 aa. Transposase for IS1081, identical to P35882|TRA1_MYCBO transposase for insertion sequence element IS1081 from Mycobacterium bovis (415 aa), FASTA scores: opt: 2680, E(): 1.9e-162, (100.0% identity in 415 aa overlap). Also highly similar to others from Mycobacterium tuberculosis e.g. P96354|Rv1047|MTCY10G2.02c|Rv3115|MTCY164.25|Rv3023c|MTV0 12 .38c (415 aa), FASTA scores: opt: 2675, E(): 3.9e-162, (99.75% identity in 415 aa overlap). Contains PS00435 Peroxidases proximal heme-ligand signature, PS01007 Transposases, Mutator family, signature. BELONGS TO THE MUTATOR FAMILY OF TRANSPOSASE.; IS1081 transposase	complement(2828556..2829803)	Mycobacterium tuberculosis H37Rv	888515
NP_217029.1	CDS	Rv2513	NC_000962.2	2830161	2830583	D	Rv2513, (MTCY07A7.19), len: 140 aa. Hypothetical unknown protein.; hypothetical protein	2830161..2830583	Mycobacterium tuberculosis H37Rv	887808
NP_217030.1	CDS	Rv2514c	NC_000962.2	2830877	2831338	R	Rv2514c, (MTCY07A7.20c), len: 153 aa. Conserved hypothetical protein, showing some similarity to Q9PG05|XF0497 HYPOTHETICAL PROTEIN from Xylella fastidiosa (155 aa), FASTA scores: opt: 215, E(): 1.4e-07, (30.6% identity in 160 aa overlap).; hypothetical protein	complement(2830877..2831338)	Mycobacterium tuberculosis H37Rv	887878
NP_217031.1	CDS	Rv2515c	NC_000962.2	2831344	2832591	R	Rv2515c, (MTCY07A7.21c), len: 415 aa. Conserved hypothetical protein, showing some similarity to Q9PG06|XF0496 HYPOTHETICAL PROTEIN from Xylella fastidiosa (391 aa), FASTA scores: opt: 388, E(): 4.4e-18, (27.8% identity in 399 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.; hypothetical protein	complement(2831344..2832591)	Mycobacterium tuberculosis H37Rv	887812
NP_217032.2	CDS	Rv2516c	NC_000962.2	2832710	2833513	R	Rv2516c, (MTV009.01c), len: 267 aa. Hypothetical unknown protein. Contains probable helix-turn-helix motif at aa 98 to 119 (Score 1743, +5.12 SD). C-terminus extended since first submission (+ 18 aa). TBparse score is 0.964.; hypothetical protein	complement(2832710..2833513)	Mycobacterium tuberculosis H37Rv	887186
NP_217033.1	CDS	Rv2517c	NC_000962.2	2833510	2833761	R	Rv2517c, (MTV009.02c), len: 83 aa. Hypothetical unknown protein. Equivalent to AAK46899 from Mycobacterium tuberculosis strain CDC1551 (97 aa) but shorter 14 aa. Questionable orf.; hypothetical protein	complement(2833510..2833761)	Mycobacterium tuberculosis H37Rv	887673
NP_217034.1	CDS	lppS	NC_000962.2	2834109	2835335	R	Rv2518c, (MTV009.03c), len: 408 aa. Probable lppS, conserved lipoprotein, highly similar to O07707|MLCL383.3 HYPOTHETICAL 43.6 KDA PROTEIN from Mycobacterium leprae (407 aa), FASTA scores: opt: 2300, E(): 1.2e-130, (82.5% identity in 406 aa overlap); Q9CCU5|LPPS|ML0426 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (404 aa), FASTA scores: opt: 2279, E(): 2.3e-129, (82.4% identity in 403 aa overlap); and Q9CB49|ML2446 POSSIBLE LIPOPROTEIN from Mycobacterium leprae (441 aa), FASTA scores: opt: 736, E(): 8.4e-37, (35.6% identity in 399 aa overlap). Also similar to other proteins from several organisms e.g. Q9X811|SC6G10.26c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (424 aa), FASTA scores: opt: 867, E(): 1.1e-44, (32.25% identity in 403 aa overlap); Q9L1E8|SC3D11.14 PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (416 aa), FASTA scores: opt: 737, E(): 7e-37, (32.95% identity in 413 aa overlap); Q9KYV1|SCE22.11 PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (407 aa), FASTA scores: opt: 721, E(): 6.2e-36, (33.5% identity in 400 aa overlap). And similar to several hypothetical mycobacterial proteins e.g. Q11149|Y483_MYCTU|Rv0483|MT0501|MTCY20G9.09 (451 aa), FASTA scores: opt: 763, E(): 2.1e-38, (34.85% identity in 402 aa overlap). Has very long signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.881.; lipoprotein LppS	complement(2834109..2835335)	Mycobacterium tuberculosis H37Rv	888160
YP_177888.1	CDS	PE26	NC_000962.2	2835785	2837263	D	Rv2519, (MTV009.04), len: 492 aa. Member of the M. tuberculosis PE family (see citation below), highly similar to many e.g. Q50630|YP91_MYCTU|Rv2591|MT2668.1|MTCY227.10c (543 aa), FASTA scores: opt: 848, E(): 3e-30, (39.55% identity in 445 aa overlap). TBparse score is 0.91.; PE family protein	2835785..2837263	Mycobacterium tuberculosis H37Rv	888172
NP_217036.1	CDS	Rv2520c	NC_000962.2	2837388	2837615	R	Rv2520c, (MTV009.05c), len: 75 aa. Possible conserved membrane protein, equivalent to O07706|MLCL383.32 HYPOTHETICAL 10.0 KDA PROTEIN from Mycobacterium leprae (91 aa), FASTA scores: opt: 290, E(): 4.1e-14, (58.65% identity in 75 aa overlap); and Q9CCU6|ML0425 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (75 aa), FASTA scores: opt: 286, E(): 6.6e-14, (57.35% identity in 75 aa overlap). TBparse score is 0.882.; hypothetical protein	complement(2837388..2837615)	Mycobacterium tuberculosis H37Rv	887804
NP_217037.1	CDS	bcp	NC_000962.2	2837684	2838157	D	Rv2521, (MTV009.06), len: 157 aa. Probable bcp, bacterioferritin comigratory protein, equivalent to O07705|BCP|ML0424 from Mycobacterium leprae (161 aa), FASTA scores: opt: 829, E(): 6.8e-46, (79.6% identity in 157 aa overlap). Also highly similar to Q9KZQ2|SCE6.38 HYPOTHETICAL 16.8 KDA PROTEIN Streptomyces coelicolor (155 aa), FASTA scores: opt: 727, E(): 2e-39, (69.5% identity in 154 aa overlap); P23480|AAG57590|BCP_ECOLI|B2480|BAB36765|Z3739|ECS3342 BACTERIOFERRITIN COMIGRATORY PROTEIN from Escherichia coli strain K12 (156 aa), FASTA scores: opt: 513, E(): 8.3e-26, (48.3% identity in 149 aa overlap); Q9RW23|DR0846 BACTERIOFERRITIN COMIGRATORY PROTEIN from Deinococcus radiodurans (175 aa), FASTA scores: opt: 465, E(): 1e-22, (46.5% identity in 157 aa overlap); P44411|BCP_HAEIN|HI0254 BACTERIOFERRITIN COMIGRATORY PROTEIN from Haemophilus influenzae (155 aa), FASTA scores: opt: 453, E(): 5.3e-22, (47.5% identity in 139 aa overlap); etc. Also similar to Mycobacterium tuberculosis Rv1608c|MTV046.06|bcpB and Rv2238c|MTCY427.19c|hpE. TBparse score is 0.897.; bacterioferritin comigratory protein BCP	2837684..2838157	Mycobacterium tuberculosis H37Rv	887694
NP_217038.1	CDS	Rv2522c	NC_000962.2	2838129	2839541	R	Rv2522c, (MTV009.07c), len: 470 aa. Conserved hypothetical protein, equivalent, but longer 20 aa, to Q9X7E4|ML1193|MLCB458.08 from HYPOTHETICAL 46.6 KDA PROTEIN Mycobacterium leprae (442 aa), FASTA scores: opt: 2521, E(): 4.1e-142, (86.35% identity in 440 aa overlap). Also similar to various proteins e.g. Q9K425|SCG22.20 PUTATIVE PEPTIDASE from Streptomyces coelicolor (451 aa), FASTA scores: opt: 1097, E(): 1.1e-57, (42.5% identity in 451 aa overlap); Q9FCK3|2SC3B6.09 PUTATIVE PEPTIDASE from Streptomyces coelicolor (470 aa), FASTA scores: opt: 669, E(): 2.8e-32, (34.2% identity in 462 aa overlap); Q98AF9|MLL6018 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (486 aa), FASTA scores: opt: 622, E(): 1.7e-29, (33.95% identity in 442 aa overlap); Q9RSU7|DR2025 ARGE/DAPE/ACY1 FAMILY PROTEIN from Deinococcus radiodurans (459 aa), FASTA scores: opt: 616, E(): 3.7e-29, (34.15% identity in 442 aa overlap); etc (include some similarity to hypothetical proteins from C. elegans and yeast). Alternative start possible at 6687 but then no RBS obvious. TBparse score is 0.899.; hypothetical protein	complement(2838129..2839541)	Mycobacterium tuberculosis H37Rv	887375
NP_217039.1	CDS	acpS	NC_000962.2	2839538	2839930	R	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase	complement(2839538..2839930)	Mycobacterium tuberculosis H37Rv	888626
NP_217040.1	CDS	fas	NC_000962.2	2840123	2849332	R	Rv2524c, (MTCY159.32, MTV009.09c), len: 3069 aa. Probable fas, Fatty Acid Synthase (EC 2.3.1.-), equivalent to Q9X7E2|FAS|ML1191 PUTATIVE TYPE I FATTY ACID SYNTHASE from Mycobacterium leprae (3076 aa), FASTA scores: opt: 17484, E(): 0, (85.8% identity in 3081 aa overlap). Also similar to others e.g. Q04846|FAS|Q59497 from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (3104 aa), FASTA scores: opt: 3981, E(): 5.5e-203, (49.8% identity in 3099 aa overlap); Q48926|FAS from Mycobacterium bovis (2796 aa), FASTA scores: opt: 2098, E(): 3.9e-103, (59.7% identity in 2862 aa overlap) (see Fernandes et al., 1996); P34731|FAS1_CANAL FATTY ACID SYNTHASE SUBUNIT BETA from Candida albicans (Yeast) (2037 aa), FASTA scores: opt: 955, E(): 1.3e-42, (27.4% identity in 1926 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00606 Beta-ketoacyl synthases active site.; fatty acid synthase	complement(2840123..2849332)	Mycobacterium tuberculosis H37Rv	887704
NP_217041.1	CDS	Rv2525c	NC_000962.2	2849852	2850574	R	Rv2525c, (MTCY159.31), len: 240 aa. Conserved hypothetical protein, equivalent to Q9X7E1|ML1190|MLCB458.05 HYPOTHETICAL 25.3 KDA PROTEIN from Mycobacterium leprae (239 aa), FASTA scores: opt: 1358, E(): 1e-75, (82.15% identity in 241 aa overlap).; hypothetical protein	complement(2849852..2850574)	Mycobacterium tuberculosis H37Rv	888612
NP_217042.1	CDS	Rv2526	NC_000962.2	2851091	2851318	D	Rv2526, (MTCY159.30c), len: 75 aa. Hypothetical unknown protein. TBparse score is 0.877.; hypothetical protein	2851091..2851318	Mycobacterium tuberculosis H37Rv	888254
NP_217043.1	CDS	Rv2527	NC_000962.2	2851315	2851716	D	Rv2527, (MTCY159.29c), len: 133 aa. Hypothetical protein, showing some similarity to hypothetical proteins from Mycobacterium tuberculosis e.g. P95007|MTCY159.10c|Rv2546 (137 aa), FASTA scores: opt: 206, E(): 1.4e-07, (38.0% identity in 100 aa overlap); O33299|MTV002.22c|Rv2757c (138 aa), FASTA scores: opt: 201, E(): 3.1e-07, (35.7% identity in 126 aa overlap); and P96411|MTCY08D5.24c|Rv0229c (226 aa), FASTA scores: opt: 153, E(): 0.0011, (32.8% identity in 128 aa overlap).; hypothetical protein	2851315..2851716	Mycobacterium tuberculosis H37Rv	887266
NP_217044.1	CDS	mrr	NC_000962.2	2851751	2852671	R	Rv2528c, (MTCY159.28), len: 306 aa. Probable mrr, restriction system protein, similar to other mrr proteins e.g. Q9RWS8|DR0587|MRR from Deinococcus radiodurans (306 aa), FASTA scores: opt: 776, E(): 4.2e-40, (40.45% identity in 309 aa overlap); P24202|MRR_ECOLI|B4351 from Escherichia coli strain K12 (304 aa), FASTA scores: opt: 647, E(): 2.9e-32, (35.25% identity in 309 aa overlap); Q9RX07|DR0508 from Deinococcus radiodurans (336 aa), FASTA scores: opt: 456, E(): 1.3e-20, (37.3% identity in 319 aa overlap); etc.; restriction system protein mrr	complement(2851751..2852671)	Mycobacterium tuberculosis H37Rv	887150
NP_217045.1	CDS	Rv2529	NC_000962.2	2852875	2854266	D	Rv2529, (MTCY159.27c), len: 463 aa. Hypothetical unknown protein. Note that C-terminal part is similar to short region of Q53609|MTS1_STRAL|SALIM MODIFICATION METHYLASE SALI from Streptomyces albus G (587 aa), FASTA scores: opt: 170, E(): 0.016, (59.45% identity in 37 aa overlap).; hypothetical protein	2852875..2854266	Mycobacterium tuberculosis H37Rv	887153
NP_217046.1	CDS	Rv2530c	NC_000962.2	2854267	2854686	R	Rv2530c, (MTCY159.26), len: 139 aa. Conserved hypothetical protein, highly similar to two HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis (strains H37Rv and CDC1551): O53219|Rv2494|MTV008.50 (141 aa), FASTA scores: opt: 380, E(): 3.6e-19, (48.0% identity in 125 aa overlap); and O53372|Rv3320c|MTV016.20c (142 aa), FASTA scores: opt: 286, E(): 9.3e-13, (41.35% identity in 133 aa overlap); and similar to others e.g. O07760|Rv0617|MTCY19H5.04c (133 aa), FASTA scores: opt: 158, E(): 0.00048, (39.55% identity in 129 aa overlap). Also some similarity with CAC48798|SMB20412 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (54 aa), FASTA scores: opt: 184, E(): 3.7e-06, (53.85% identity in 52 aa overlap); and CAC48797|SMB20411 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (82 aa), FASTA scores: opt: 170, E(): 4.8e-05, (44.45% identity in 63 aa overlap).; hypothetical protein	complement(2854267..2854686)	Mycobacterium tuberculosis H37Rv	887192
YP_177672.1	CDS	Rv2530A	NC_000962.2	2854683	2854907	R	Rv2530A, len: 74 aa. Conserved hypothetical protein, similar to Q9CCR7|ML0525 HYPOTHETICAL PROTEIN from Mycobacterium leprae (58 aa), FASTA scores: opt: 179, E(): 1.8e-06, (63.65% identity in 44 aa overlap). Highly similar to O53218|Rv2493 from Mycobacterium tuberculosis (73 aa), FASTA scores: opt: 240, E(): 5.7e-11, (56.75% identity in 74 aa overlap); and Q92WE1|RB0399|SMB20413 HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti)p lasmid pSymB (megaplasmid 2) (75 aa), FASTA scores: opt: 226, E(): 6.5e-10, (56.00% identity in 75 aa overlap).; hypothetical protein	complement(2854683..2854907)	Mycobacterium tuberculosis H37Rv	3205085
YP_177889.1	CDS	Rv2531c	NC_000962.2	2854938	2857781	R	Rv2531c, (MTCY159.25), len: 947 aa. Probable amino acid decarboxylase (EC 4.1.1.-), equivalent to Q9CCR8|ADI|ML0524 PUTATIVE AMINO ACID DECARBOXYLASE from Mycobacterium leprae (950 aa), FASTA scores: opt: 5426, E(): 0, (86.45% identity in 951 aa overlap). Also similar to other amino acid decarboxylases (but longer in N-terminus) e.g. Q9I2S7|PA1818 PROBABLE ORN/ARG/LYS AMINO ACID DECARBOXYLASE from Pseudomonas aeruginosa (751 aa), FASTA scores: opt: 434, E(): 2.5e-19, (29.15% identity in 738 aa overlap); Q9CML3|SPEF|PM0806 ORNITHINE DECARBOXYLASE from Pasteurella multocida (720 aa), FASTA scores: opt: 402, E(): 2.4e-17, (24.85% identity in 752 aa overlap); P21169|DCOR_ECOLI|SPEC|B2965|BAB37264|ECS3841|AAG58096 ORNITHINE DECARBOXYLASE ISOZYME (CONSTITUTIVE ENZYME) from Escherichia coli strain K12 (711 aa), FASTA scores: opt: 396, E(): 5.6e-17, (28.0% identity in 646 aa overlap); P44317|DCOR_HAEIN|SPEF|HI0591 ORNITHINE DECARBOXYLASE from Haemophilus influenzae (720 aa), FASTA scores: opt: 393, E(): 8.8e-17, (25.05% identity in 743 aa overlap) ; etc. SEEMS TO BELONG TO FAMILY 1 OF ORNITHINE, LYSINE, AND ARGININE DECARBOXYLASES. Note that previously known as adi.; adi; amino acid decarboxylase	complement(2854938..2857781)	Mycobacterium tuberculosis H37Rv	887216
NP_217048.1	CDS	Rv2532c	NC_000962.2	2857853	2858254	R	Rv2532c, (MTCY159.24), len: 133 aa. Hypothetical unknown protein, equivalent to AAK46918 from Mycobacterium tuberculosis strain CDC1551 but shorter 157 aa.; hypothetical protein	complement(2857853..2858254)	Mycobacterium tuberculosis H37Rv	887152
NP_217049.1	CDS	nusB	NC_000962.2	2858254	2858724	R	Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB	complement(2858254..2858724)	Mycobacterium tuberculosis H37Rv	887359
NP_217050.1	CDS	efp	NC_000962.2	2858727	2859290	R	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P	complement(2858727..2859290)	Mycobacterium tuberculosis H37Rv	888437
NP_217051.1	CDS	pepQ	NC_000962.2	2859300	2860418	R	Rv2535c, (MTCY159.21), len: 372 aa. Probable pepQ, cytoplasmic peptidase (EC 3.4.-.-), equivalent to Q9CCS1|PEPQ|ML0521 PUTATIVE CYTOPLASMIC PEPTIDASE from Mycobacterium leprae (376 aa), FASTA scores: opt: 1954, E(): 1.1e-105, (82.7% identity in 376 aa overlap). Also similar to other peptidases e.g. P54518|YQHT_BACSU PUTATIVE PEPTIDASE (BELONGS TO PEPTIDASE FAMILY M24B) from Bacillus subtilis (353 aa), FASTA scores: opt: 808, E(): 1.6e-39, (39.65% identity in 368 aa overlap); Q9KXQ8|SC9C5.16c PUTATIVE PEPTIDASE from Streptomyces coelicolor (368 aa), FASTA scores: opt: 803, E(): 3.2e-39, (43.15% identity in 380 aa overlap); Q9K950|BH2800 XAA-PRO DIPEPTIDASE from Bacillus halodurans (355 aa), FASTA scores: opt: 801, E(): 4.1e-39, (39.45% identity in 365 aa overlap); etc. Note that second part of protein is similar to second part of MTCY49.29c|Rv2089c|MT2150|MTCY49.29c PROBABLE DIPEPTIDASE (EC 3.4.13.-; BELONGS TO PEPTIDASE FAMILY M24B) from Mycobacterium tuberculosis (375 aa) (33.9% identity in 354 aa overlap) BLAST RESULTS: Score: 142 bits (359), E: 4e-33, Identities: 86/224 (38%), Positives: 119/224 (52%), Gaps: 4/224 (1%). COULD BE BELONG TO PEPTIDASE FAMILY M24B.; cytoplasmic peptidase PepQ	complement(2859300..2860418)	Mycobacterium tuberculosis H37Rv	888409
NP_217052.1	CDS	Rv2536	NC_000962.2	2860452	2861144	D	Rv2536, (MTCY159.20c), len: 230 aa. Probable conserved transmembrane protein, equivalent to Q9CCS2|ML0520 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (202 aa), FASTA scores: opt: 812, E(): 2e-41, (63.2% identity in 201 aa overlap). Also similar in part to Q9HMD5|VNG2594c from Halobacterium sp. strain NRC-1 (117 aa), FASTA scores: opt: 33.6, E(): 1.8, (33.6% identity in 116 aa overlap); and perhaps AAK65752|SMA1996 PUTATIVE ABC TRANSPORTER PERMEASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (323 aa), FASTA scores: opt: 117, E(): 6.1, (30.6% identity in 121 aa overlap). TBparse score is 0.876.; transmembrane protein	2860452..2861144	Mycobacterium tuberculosis H37Rv	888386
NP_217053.1	CDS	aroD	NC_000962.2	2861148	2861591	R	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase	complement(2861148..2861591)	Mycobacterium tuberculosis H37Rv	888397
NP_217054.1	CDS	aroB	NC_000962.2	2861588	2862676	R	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase	complement(2861588..2862676)	Mycobacterium tuberculosis H37Rv	888392
NP_217055.1	CDS	aroK	NC_000962.2	2862673	2863203	R	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase	complement(2862673..2863203)	Mycobacterium tuberculosis H37Rv	887434
NP_217056.1	CDS	aroF	NC_000962.2	2863207	2864412	R	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase	complement(2863207..2864412)	Mycobacterium tuberculosis H37Rv	887379
NP_217057.1	CDS	Rv2541	NC_000962.2	2864427	2864834	D	Rv2541, (MTCY159.15c), len: 135 aa. Hypothetical unknown ala-rich protein, equivalent to AAK46926|MT2615.1 HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 but AAK46926|MT2615.1 longer at C-terminus. Questionable ORF. Some similarity with Rv2077A from Mycobacterium tuberculosis (99 aa).; hypothetical protein	2864427..2864834	Mycobacterium tuberculosis H37Rv	887831
NP_217058.1	CDS	Rv2542	NC_000962.2	2865130	2866341	D	Rv2542, (MTCY159.14c), len: 403 aa. Conserved hypothetical protein, highly similar to AAK46927|MT2616 HYPOTHETICAL 28.0 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (265 aa), FASTA scores: opt: 1776, E(): 2.3e-94, (99.25% identity in 265 aa overlap). And similar to several hypothetical proteins from Mycobacterium tuberculosis (strain H37Rv and CDC1551) e.g. P71654|Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: opt: 537, E(): 2.6e-23, (40.75% identity in 292 aa overlap); P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 (266 aa), FASTA scores: opt: 357, E(): 2.6e-13, (34.6% identity in 234 aa overlap); Q10685|YK77_MYCTU|Rv2077c|MT2137|MTCY49.16c (323 aa), FASTA scores: opt: 261, E(): 9.5e-08, (32.7% identity in 211 aa overlap); etc. Also similar to Q9RDQ9|SC4A7.03 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (406 aa), FASTA scores: opt: 247, E(): 7.3e-07, (30.35% identity in 303 aa overlap).; hypothetical protein	2865130..2866341	Mycobacterium tuberculosis H37Rv	887261
NP_217059.1	CDS	lppA	NC_000962.2	2866468	2867127	D	Rv2543, (MTCY159.13c), len: 219 aa. Probable lppA, conserved lipoprotein, highly similar to upstream ORF P95009|LPPB|Rv2544|MTCY159.12 PUTATIVE LIPOPROTEIN LPPB from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 1240, E(): 1.1e-73, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LppA	2866468..2867127	Mycobacterium tuberculosis H37Rv	888052
NP_217060.1	CDS	lppB	NC_000962.2	2867124	2867786	D	Rv2544, (MTCY159.12c), len: 220 aa. Probable lppB, conserved lipoprotein, highly similar to downstream ORF P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 PUTATIVE LIPOPROTEIN LPPA from Mycobacterium tuberculosis (219 aa), FASTA scores: opt: 1242, E(): 4.8e-72, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.924.; lipoprotein LppB	2867124..2867786	Mycobacterium tuberculosis H37Rv	888054
NP_217061.1	CDS	Rv2545	NC_000962.2	2867783	2868061	D	Rv2545, (MTY159.11c), len: 92 aa. Conserved hypothetical protein. C-terminus highly similar to O33300|Rv2758c|MTV002.23c PROTEIN from Mycobacterium tuberculosis (88 aa), FASTA scores: opt: 151, E(): 9.8e-05, (66.65% identity in 45 aa overlap); and Q10771|Rv1560|MT1611|MTCY48.05 PROTEIN from Mycobacterium tuberculosis (72 aa), FASTA scores: opt: 84, E(): 8.2, (46.5% identity in 43 aa overlap).; hypothetical protein	2867783..2868061	Mycobacterium tuberculosis H37Rv	888038
NP_217062.1	CDS	Rv2546	NC_000962.2	2868154	2868567	D	Rv2546, (MTCY159.10c), len: 137 aa. Conserved hypothetical protein. Some similarity to several HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis (strain H37Rv and CDC1551) e.g. P96411|Rv0229c|MTCY08D5.24c (226 aa), FASTA scores: opt: 272, E(): 1.3e-11, (39.7% identity in 136 aa overlap); O33299|Rv2757c|MTV002.22c (138 aa), FASTA scores: opt: 265, E(): 2.5e-11, (38.5% identity in 135 aa overlap); P95026|Rv2527|MTCY159.29c (133 aa), FASTA scores: opt: 206, E(): 2.6e-07, (38.0% identity in 100 aa overlap); etc.; hypothetical protein	2868154..2868567	Mycobacterium tuberculosis H37Rv	887365
NP_217063.1	CDS	Rv2547	NC_000962.2	2868606	2868863	D	Rv2547, (MTCY159.09c), len: 85 aa. Conserved hypothetical protein. Some similarity to P71666|YD98_MYCTU|Rv1398c|MT1442|MTCY21B4.15c HYPOTHETICAL 9.4 KDA PROTEIN from Mycobacterium tuberculosis (85 aa), FASTA scores: opt: 108, E(): 0.33, (37.1% identity in 62 aa overlap); CAC45864|SMC01933 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (71 aa), FASTA scores: opt: 105, E(): 0.46, (28.4% identity in 74 aa overlap); Q97W38|SSO10342 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (58 aa), FASTA scores: opt: 94, E(): 2.3, (46.95% identity in 49 aa overlap).; hypothetical protein	2868606..2868863	Mycobacterium tuberculosis H37Rv	888452
NP_217064.1	CDS	Rv2548	NC_000962.2	2868860	2869237	D	Rv2548, (MTCY159.08c), len: 125 aa. Conserved hypothetical protein. Some similarity to various proteins e.g. P71665|Rv1397c|MTCY21B4.14c HYPOTHETICAL 15.0 KDA PROTEIN from Mycobacterium tuberculosis (133 aa), FASTA scores: opt: 265, E(): 7.1e-12, (42.3% identity in 123 aa overlap); Q97WY5|SSO1975 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (125 aa), FASTA scores: opt: 131, E(): 0.018, (30.0% identity in 110 aa overlap); O52285|YLE HYPOTHETICAL 14.9 KDA PROTEIN from Agrobacterium radiobacter (133 aa), FASTA scores: opt: 128, E(): 0.03, (32.8% identity in 125 aa overlap); etc. TBscore is 0.865.; hypothetical protein	2868860..2869237	Mycobacterium tuberculosis H37Rv	888412
NP_217065.1	CDS	Rv2549c	NC_000962.2	2869727	2870122	R	Rv2549c, (MTCY159.07), len: 131 aa. Conserved hypothetical protein, showing some similarity to P73415|SLL1715 from Synechocystis sp. strain PCC 6803 (157 aa), FASTA scores: opt: 167, E(): 4.2e-05, (29.45% identity in 129 aa overlap); Q9HHY6|VNG6166H from Halobacterium sp. plasmid pNRC200 strain NRC-1 (144 aa), FASTA scores: opt: 133, E(): 0.011, (29.6% identity in 125 aa overlap); and Q9HSU3|VNG0072H from Halobacterium sp. strain NRC-1 (144 aa), FASTA scores: opt: 113, E(): 0.29, (25.75% identity in 136 aa overlap).; hypothetical protein	complement(2869727..2870122)	Mycobacterium tuberculosis H37Rv	887193
NP_217066.1	CDS	Rv2550c	NC_000962.2	2870119	2870364	R	Rv2550c, (MTCY159.06), len: 81 aa. Hypothetical unknown protein.; hypothetical protein	complement(2870119..2870364)	Mycobacterium tuberculosis H37Rv	887353
NP_217067.1	CDS	Rv2551c	NC_000962.2	2870775	2871194	R	Rv2551c, (MTCY159.05), len: 139 aa. Conserved hypothetical protein, similar to the second part of Q9XAP1|SC10A7.34c PUTATIVE TYPE IV PEPTIDASE from Streptomyces coelicolor (259 aa), FASTA scores: opt: 243, E(): 7.4e-08, (40.95% identity in 144 aa overlap). Also some similarity with other proteins e.g. AAK58497|GSPO GSPO PROTEIN from Acetobacter diazotrophicus (261 aa), FASTA scores: opt: 152, E(): 0.025, (33.35% identity in 135 aa overlap).; hypothetical protein	complement(2870775..2871194)	Mycobacterium tuberculosis H37Rv	887855
NP_217068.1	CDS	aroE	NC_000962.2	2871206	2872015	R	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase	complement(2871206..2872015)	Mycobacterium tuberculosis H37Rv	887330
NP_217069.1	CDS	Rv2553c	NC_000962.2	2872012	2873265	R	Rv2553c, (MTCY159.03), len: 417 aa. Probable conserved membrane protein, equivalent to Q9CCS8|ML0514 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (421 aa), FASTA scores: opt: 1955, E(): 1.1e-111, (72.7% identity in 414 aa overlap). Also similar in part to various proteins e.g. Q9L9G6|NOVB NOVB PROTEIN (aminodesoxychorismate lyase) from Streptomyces sphaeroides (284 aa), FASTA scores: opt: 451, E(): 2.9e-2, (37.95% identity in 203 aa overlap); Q9EWY3|2SCG38.36 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (253 aa), FASTA scores: opt: 419, E(): 2.3e-18, (39.2% identity in 171 aa overlap); Q9CHT3|YGCC HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (550 aa), FASTA scores: opt: 379, E(): 1.2e-15, (23.0% identity in 417 aa overlap); O25309|HP0587 AMINODEOXYCHORISMATE LYASE (PABC) from Helicobacter pylori (Campylobacter pylori) (329 aa), FASTA scores: opt: 290, E(): 2e-10, (31.65% identity in 180 aa overlap); etc.; hypothetical protein	complement(2872012..2873265)	Mycobacterium tuberculosis H37Rv	888228
NP_217070.1	CDS	Rv2554c	NC_000962.2	2873258	2873770	R	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein	complement(2873258..2873770)	Mycobacterium tuberculosis H37Rv	887490
NP_217071.1	CDS	alaS	NC_000962.2	2873771	2876485	R	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase	complement(2873771..2876485)	Mycobacterium tuberculosis H37Rv	887726
NP_217072.1	CDS	Rv2556c	NC_000962.2	2876576	2876965	R	Rv2556c, (MTCY09C4.12), len: 129 aa. Conserved hypothetical protein, highly similar to others e.g. Q9EWY5|2SCG38.34 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (140 aa), FASTA scores: opt: 488, E(): 8.2e-26, (58.8% identity in 131 aa overlap); Q9L9G4|NOVD NOVD PROTEIN from Streptomyces sphaeroides (143 aa), FASTA scores: opt: 474, E(): 7.2e-25, (60.85% identity in 120 aa overlap); Q9X2I5|TM1872 from Thermotoga maritima (132 aa), FASTA scores: opt: 270, E(): 2.7e-11, (39.55% identity in 129 aa overlap); etc.; hypothetical protein	complement(2876576..2876965)	Mycobacterium tuberculosis H37Rv	887451
NP_217073.1	CDS	Rv2557	NC_000962.2	2877072	2877746	D	Rv2557, (MTCY9C4.11c), len: 224 aa. Conserved hypothetical protein, highly similar to upstream ORF Q50740|MTCY9C4.10c|Rv2558|MT2635 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (236 aa), FASTA scores: opt: 1007, E(): 6.9e-60, (69.2% identity in 224 aa overlap); and Mb2587 in Mycobacterium bovis (224 aa).; hypothetical protein	2877072..2877746	Mycobacterium tuberculosis H37Rv	887865
NP_217074.1	CDS	Rv2558	NC_000962.2	2877831	2878541	D	Rv2558, (MTCY9C4.10c), len: 236 aa. Conserved hypothetical protein, highly similar to downstream ORF Q50741|MTCY9C4.11c|Rv2557|MT2645 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (224 aa), FASTA scores: opt: 1007, E(): 4.7e-59, (69.2% identity in 224 aa overlap); and Mb2588 in Mycobacterium bovis (236 aa).; hypothetical protein	2877831..2878541	Mycobacterium tuberculosis H37Rv	887298
NP_217075.1	CDS	Rv2559c	NC_000962.2	2878571	2879929	R	Rv2559c, (MTCY9C4.09), len: 452 aa. Conserved hypothetical ala-, leu-, val-rich protein, equivalent to Q9CCT1|ML0510 HYPOTHETICAL PROTEIN from Mycobacterium leprae (473 aa), FASTA scores: opt: 2411, E(): 3.9e-121, (83.4% identity in 452 aa overlap); O69490|O69490 HYPOTHETICAL 47.1 KDA PROTEIN from Mycobacterium leprae (447 aa), FASTA scores: opt: 2406, E(): 6.9e-121, (83.95% identity in 448 aa overlap). Also highly similar to Q9KXP4|SC9C5.30c CONSERVED ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (451 aa), FASTA scores: opt: 1742, E(): 1.5e-85, (64.4% identity in 430 aa overlap); Q9RT67|DR1898 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (434 aa), FASTA scores: opt: 1147, E(): 6.6e-54, (46.0% identity in 415 aa overlap); P45262|YCAJ_HAEIN|HI1590 HYPOTHETICAL PROTEIN from Haemophilus influenzae (446 aa), FASTA scores: opt: 1140, E(): 1.6e-53, (42.5% identity in 428 aa overlap); etc. Also similar to Q50629|MTCY227.09|RUVB|Rv2592c|MT2669|MTCY227.09 HOLLIDAY JUNCTION DNA HELICASE from Mycobacterium tuberculosis (344 aa), (30.1% identity in 296 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; recombination factor protein RarA	complement(2878571..2879929)	Mycobacterium tuberculosis H37Rv	887368
NP_217076.1	CDS	Rv2560	NC_000962.2	2880075	2881052	D	Rv2560, (MTCY9C4.08c), len: 325 aa. Probable transmembrane protein, pro-, gly-rich protein.; hypothetical protein	2880075..2881052	Mycobacterium tuberculosis H37Rv	887363
NP_217077.1	CDS	Rv2561	NC_000962.2	2881409	2881702	D	Rv2561, (MTCY9C4.07c), len: 97 aa. Conserved hypothetical protein, highly similar in part (and longer 33 aa) to upstream ORF AAK46951|RV2562|MT2638|MTCY9C4.06c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (212 aa), FASTA scores: opt: 205, E(): 2e-06, (76.1% identity in 46 aa overlap).; hypothetical protein	2881409..2881702	Mycobacterium tuberculosis H37Rv	887164
NP_217078.1	CDS	Rv2562	NC_000962.2	2881758	2882147	D	Rv2562, (MTCY9C4.06c), len: 129 aa. Conserved hypothetical protein, highly similar, but shorter 83 aa, to downstream ORF AAK46951|RV2561|MT2638|MTCY9C4.07c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (97 aa), FASTA scores: opt: 866, E(): 2.2e-54, (100.0% identity in 129 aa overlap).; hypothetical protein	2881758..2882147	Mycobacterium tuberculosis H37Rv	887329
NP_217079.1	CDS	Rv2563	NC_000962.2	2882290	2883339	D	Rv2563, (MTCY9C4.05c), len: 349 aa. Probable glutamine-transport transmembrane protein ABC transporter (see citation below), highly similar to O53617|Rv0072|MTV030.16 PUTATIVE ABC-TRANSPORTER TRANSMEMBRANE SUBUNIT from Mycobacterium tuberculosis (349 aa), FASTA scores: opt: 1772, E(): 1.1e-89, (76.2% identity in 349 aa overlap). Also some similarity with various hypothetical proteins e.g. Q9RYN1|DRA0279 HYPOTHETICAL 37.1 KDA PROTEIN from Deinococcus radiodurans (353 aa), FASTA scores: opt: 347, E(): 6.6e-12, (24.35% identity in 357 aa overlap); BAB58522|SAV2360 CONSERVED HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (351 aa), FASTA scores: opt: 262, E(): 2.9e-07, (19.4% identity in 356 aa overlap); Q9AK94|SC10A9.10c PUTATIVE ABC TRANSPORT SYSTEM TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (379 aa), FASTA scores: opt: 172, E(): 0.025, (26.85% identity in 387 aa overlap); etc.; glutamine-transport transmembrane protein ABC transporter	2882290..2883339	Mycobacterium tuberculosis H37Rv	887516
NP_217080.1	CDS	glnQ	NC_000962.2	2883342	2884334	D	Rv2564, (MTCY9C4.04c), len: 330 aa. Probable glnQ, glutamine-transport ATP-binding protein ABC transporter (see citation below), highly similar to many e.g. Q9L0J9|SCD40A.12c PUTATIVE ABC-TRANSPORTER ATP-BINDING PROTEIN from Streptomyces coelicolor (246 aa), FASTA scores: opt: 598, E(): 2.5e-26, (46.35% identity in 218 aa overlap); O54136|SC2E9.11 from Streptomyces coelicolor (230 aa), FASTA scores: opt: 592, E(): 5.1e-26, (46.55% identity in 219 aa overlap); O29244|AF1018 from Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 580, E(): 2.4e-25, (42.4% identity in 210 aa overlap); P75831|YBJZ_ECOLI|B0879 from Escherichia coli strain K12 (648 aa), FASTA scores: opt: 555, E(): 1.3e-23, (39.65% identity in 232 aa overlap); etc. Also highly similar to O53618|Rv0073|MTV030.17 ABC-TRANSPORTER ATP-BINDING SUBUNIT from Mycobacterium tuberculosis (330 aa), FASTA scores: opt: 1782, E(): 4.7e-92, (83.65% identity in 330 aa overlap); etc. Shows some similarity to Q11040|YC81_MYCTU|MTCY50.01|Rv1281c|MT1318 HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium tuberculosis (612 aa) (32.9 % identity in 234 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; glutamine-transport ATP-binding protein ABC transporter GlnQ	2883342..2884334	Mycobacterium tuberculosis H37Rv	887898
NP_217081.1	CDS	Rv2565	NC_000962.2	2884611	2886362	D	Rv2565, (MTCY9C4.03c), len: 583 aa. Conserved hypothetical protein, similar in part to Q9A6C3|CC2171 HYPOTHETICAL PROTEIN from Caulobacter crescentus (610 aa), FASTA scores: opt: 765, E(): 2.8e-37, (32.15% identity in 575 aa overlap). C-terminus also highly similar to various bacterial proteins e.g. O34731|YLBK_BACSU HYPOTHETICAL 28.3 KDA PROTEIN from Bacillus subtilis (260 aa), FASTA scores: opt: 386, E(): 2.2e-15, (33.05% identity in 245 aa overlap); CAC45997|SMC01003 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (321 aa), FASTA scores: opt: 352, E(): 2.5e-13, (29.65% identity in 280 aa overlap); Q9K9Q8|BH2587 HYPOTHETICAL PROTEIN from Bacillus halodurans (275 aa), FASTA scores: opt: 334, E(): 2.5e-12, (33.7% identity in 175 aa overlap); etc. And shows similarity to C-terminal half of some eukaryotic proteins e.g. Q9R114|NTE NEUROPATHY TARGET ESTERASE HOMOLOG from Mus musculus (Mouse) (1327 aa), FASTA scores: opt: 411, E(): 2.7e-16, (24.45% identity in 626 aa overlap); O60859 NEUROPATHY TARGET ESTERASE from Homo sapiens (Human) (1327 aa), FASTA scores: opt: 410, E(): 3.1e-16, (24.1% identity in 627 aa overlap); Q9U969|SWS|CG2212 SWISS CHEESE PROTEIN from Drosophila melanogaster (Fruit fly) (1425 aa), FASTA scores: opt: 401, E(): 1.1e-15, (27.75% identity in 544 aa overlap); etc. Also shows strong similarity to C-terminal half of O05884|Z95121|Rv3239c|MTY20B11.14c HYPOTHETICAL 110.2 KDA PROTEIN from Mycobacterium tuberculosis (1048 aa), FASTA scores: opt: 648, E(): 3e-30, (36.55% identity in 572 aa overlap); and O69695|Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN MEMBRANE PROTEIN from Mycobacterium tuberculosis (1065 aa), FASTA scores: opt: 643, E(): 6e-30, (34.3% identity in 595 aa overlap).; hypothetical protein	2884611..2886362	Mycobacterium tuberculosis H37Rv	887288
NP_217082.1	CDS	Rv2566	NC_000962.2	2886373	2889795	D	Rv2566, (MTCY9C4.02c), len: 1140 aa. Long conserved hypothetical protein, equivalent to O53120|ML2678 OR MLCB1913.12 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1000 aa), FASTA scores: opt: 760, E(): 7.1e-38, (50.2% identity in 1128 aa overlap); and middle part equivalent to Q9ZB40 72.2 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (644 aa), FASTA scores: opt: 1017, E(): 1.5e-65, (45.65% identity in 655 aa overlap). Also highly similar to Q98HG6|MLL2877 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (1119 aa), FASTA scores: opt: 1413, E(): 3.7e-77, (52.4% identity in 1148 aa overlap); and N-terminus shows similarity with other proteins e.g. Q9HUN8|PA4926 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (311 aa), FASTA scores: opt: 278, E(): 3e-09, (29.95% identity in 284 aa overlap); and upstream ORF Q50652|YP69_MYCTU|Rv2569c|MT2645|MTCY227.32 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (314 aa), FASTA scores: opt: 252, E(): 1.1e-07, (28.9% identity in 315 aa overlap). Equivalent to AAK46955 from Mycobacterium tuberculosis strain CDC1551 (1156 aa) but shorter 16 aa.; hypothetical protein	2886373..2889795	Mycobacterium tuberculosis H37Rv	887737
NP_217083.1	CDS	Rv2567	NC_000962.2	2889795	2892449	D	Rv2567, (MTCY227.34c, MTCY9C4.01c), len: 884 aa. Conserved hypothetical ala-, leu-rich protein, equivalent to O53121|ML2679|MLCB1913.13 HYPOTHETICAL PROTEIN from Mycobacterium leprae (893 aa), FASTA scores: opt: 4326, E(): 0, (75.2% identity in 883 aa overlap); and similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 HYPOTHETICAL 61.8 KDA PROTEIN from Mycobacterium leprae (561 aa), FASTA scores: opt: 758, E(): 1.2e-38, (32.2% identity in 537 aa overlap). Also similar to others e.g. Q9HUN7|PA4927 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (830 aa), FASTA scores: opt: 1247, E(): 2.2e-68, (38.25% identity in 831 aa overlap); Q98HG7|MLL2876 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (803 aa), FASTA scores: opt: 937, E(): 1.9e-49, (32.15% identity in 828 aa overlap); CAC47419|SMC04057 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (802 aa), FASTA scores: opt: 900, E(): 3.4e-47, (30.85% identity in 852 aa overlap); etc. And similar to P71732|YO11_MYCTU|Rv2411c|MT2484|MTCY253.09 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (551 aa), FASTA scores: opt: 781, E(): 4.6e-40, (33.75% identity in 495 aa overlap).; hypothetical protein	2889795..2892449	Mycobacterium tuberculosis H37Rv	888578
NP_217084.1	CDS	Rv2568c	NC_000962.2	2892446	2893471	R	Rv2568c, (MTCY227.33), len: 341 aa. Conserved hypothetical protein, highly similar (but longer 60 aa) to Q98E75|MLR4376 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (308 aa), FASTA scores: opt: 566, E(): 4.1e-29, (40.2% identity in 291 aa overlap).; hypothetical protein	complement(2892446..2893471)	Mycobacterium tuberculosis H37Rv	887249
NP_217085.1	CDS	Rv2569c	NC_000962.2	2893464	2894408	R	Rv2569c, (MTCY227.32), len: 314 aa. Conserved hypothetical protein, equivalent to Q9CCT2|ML0508 HYPOTHETICAL PROTEIN from Mycobacterium leprae (313 aa), FASTA scores: opt: 1723, E(): 1.9e-95, (84.4% identity in 301 aa overlap); and some similarity with Q49757|YP69_MYCLE|ML0607|MLCL536.03c|B1937_F2_39 HYPOTHETICAL 31.1 KDA PROTEIN from Mycobacterium leprae (279 aa), FASTA scores: opt: 305, E(): 4.5e-11, (33.0% identity in 300 aa overlap). Also similar to to other hypothetical proteins e.g. Q9HUN8|PA4926 from Pseudomonas aeruginosa (311 aa), FASTA scores: opt: 704, E(): 8.7e-35, (39.7% identity in 320 aa overlap); Q98HG8|MLL2875 from Rhizobium loti (Mesorhizobium loti) (294 aa), FASTA scores: opt: 521, E(): 6.5e-24, (35.05% identity in 294 aa overlap); Q9A7W9|CC1600 from Caulobacter crescentus (325 aa), FASTA scores: opt: 510, E(): 3.2e-23, (34.4% identity in 2588 aa overlap); etc. Also some similarity with proteins from Mycobacterium tuberculosis e.g. P71734|Rv2409c|MTCY253.11 CONSERVED HYPOTHETICAL PROTEIN (279 aa), FASTA scores: opt: 312, E(): 1.7e-11, (34.45% identity in 296 aa overlap); and Q50732|Rv2566|MTCY9C4.02 LONG CONSERVED HYPOTHETICAL PROTEIN (1140 aa), FASTA scores: opt: 252, E(): 2.2e-07, (28.9% identity in 315 aa overlap); hypothetical protein	complement(2893464..2894408)	Mycobacterium tuberculosis H37Rv	887783
NP_217086.1	CDS	Rv2570	NC_000962.2	2894512	2894901	D	Rv2570, (MTCY227.31c), len: 129 aa. Conserved hypothetical protein, similar to Q98GQ7|MLR3218 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (133 aa), FASTA scores: opt: 174, E(): 9.6e-05, (32.25% identity in 124 aa overlap); Q9A390|CC3314 HYPOTHETICAL PROTEIN from Caulobacter crescentus (129 aa), FASTA scores: opt: 155, E(): 0.0017, (33.35% identity in 108 aa overlap); and Q9A2Y0|CC3426 HYPOTHETICAL PROTEIN from Caulobacter crescentus (120 aa), FASTA scores: opt: 144, E(): 0.0083, (32.95% identity in 91 aa overlap).; hypothetical protein	2894512..2894901	Mycobacterium tuberculosis H37Rv	887377
NP_217087.1	CDS	Rv2571c	NC_000962.2	2894893	2895960	R	Rv2571c, (MTCY227.30), len: 355 aa. Probable transmembrane ala-, val-, leu-rich protein, showing some similarity with other membrane proteins e.g. Q99340|YFDA_CORGL HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (359 aa), FASTA scores: opt: 338, E(): 2.5e-13, (29.4% identity in 255 aa overlap); Q9RD86|SCF43.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (379 aa), FASTA scores: opt: 208, E(): 2.1e-05, (26.05% identity in 303 aa overlap); Q9RD81|SCF43.07 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (419 aa), FASTA scores: opt: 205, E(): 3.5e-05, (25.15% identity in 362 aa overlap); etc.; transmembrane alanine and valine and leucine rich protein	complement(2894893..2895960)	Mycobacterium tuberculosis H37Rv	887382
NP_217088.1	CDS	aspS	NC_000962.2	2896013	2897803	R	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase	complement(2896013..2897803)	Mycobacterium tuberculosis H37Rv	888532
NP_217089.2	CDS	Rv2573	NC_000962.2	2897956	2898783	D	ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase	2897956..2898783	Mycobacterium tuberculosis H37Rv	888188
NP_217090.1	CDS	Rv2574	NC_000962.2	2898806	2899309	D	Rv2574, (MTCY227.27c), len: 167 aa. Conserved hypothetical protein, showing similarity with Q9K3N3|SCG20A.07 HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (157 aa), FASTA scores: opt: 218, E(): 2.8e-08, (30.65% identity in 150 aa overlap).; hypothetical protein	2898806..2899309	Mycobacterium tuberculosis H37Rv	887232
NP_217091.1	CDS	Rv2575	NC_000962.2	2899339	2900220	D	Rv2575, (MTCY227.26c), len: 293 aa. Possible conserved membrane gly-rich protein, highly similar to hypothetical proteins e.g. Q9RR98|DR2596 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (313 aa), FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity in 291 aa overlap); Q9HV81|PA4717 from Pseudomonas aeruginosa (297 aa), FASTA scores: opt: 641, E(): 1.5e-32, (43.35% identity in 300 aa overlap); Q98IA4|MLL2493 from Rhizobium loti (Mesorhizobium loti) (306 aa), FASTA scores: opt: 628, E(): 1e-31, (38.45% identity in 307 aa overlap); etc. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.; hypothetical protein	2899339..2900220	Mycobacterium tuberculosis H37Rv	888178
NP_217092.1	CDS	Rv2576c	NC_000962.2	2900226	2900690	R	Rv2576c, (MTCY227.25), len: 154 aa. Possible conserved membrane protein, showing similarity with Q9ZFC2 HYPOTHETICAL 15.7 KDA PROTEIN from Mycobacterium sp. FM10 (146 aa), FASTA scores: opt: 235, E(): 4.1e-08, (31.35% identity in 150 aa overlap).; hypothetical protein	complement(2900226..2900690)	Mycobacterium tuberculosis H37Rv	887251
NP_217093.1	CDS	Rv2577	NC_000962.2	2900918	2902507	D	Rv2577, (MTCY227.24c), len: 529 aa. Conserved hypothetical protein, showing similarity with various proteins from eukaryotes, in particular phosphatases, e.g. Q9SE01|PAP PURPLE ACID PHOSPHATASE PRECURSOR (EC 3.1.3.2) from Glycine max (Soybean) (464 aa), FASTA scores: opt: 190, E(): 0.00026, (27.3% identity in 388 aa overlap); Q9SVP2|F18A5.90|AT4G13700 HYPOTHETICAL 53.4 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (474 aa), FASTA scores: opt: 280, E(): 6.6e-10, (27.2% identity in 331 aa overlap); Q9FK32 SIMILARITY TO UNKNOWN PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (529 aa), FASTA scores: opt: 249, E(): 6.2e-08, (25.3% identity in 435 aa overlap); Q12546|APHA ACID PHOSPHATASE PRECURSOR from Aspergillus ficuum (614 aa), FASTA scores: opt: 207, E(): 2.9e-05, (22.95% identity in 458 aa overlap); etc.; hypothetical protein	2900918..2902507	Mycobacterium tuberculosis H37Rv	888207
NP_217094.1	CDS	Rv2578c	NC_000962.2	2902509	2903531	R	Rv2578c, (MTCY227.23), len: 340 aa. Conserved hypothetical protein, highly similar to hypothetical proteins (conserved or not) e.g. Q9ZBJ3|SC9C7.17c from Streptomyces coelicolor (348 aa), FASTA scores: opt: 998, E(): 1.6e-55, (47.6% identity in 355 aa overlap); Q9I763|PA0069 from Pseudomonas aeruginosa (352 aa), FASTA scores: opt: 560, E(): 6e-28, (36.6% identity in 284 aa overlap); Q986C9|MLL7417 from Rhizobium loti (Mesorhizobium loti) (356 aa), FASTA scores: opt: 550, E(): 2.6e-27, (39.15% identity in 240 aa overlap); etc.; hypothetical protein	complement(2902509..2903531)	Mycobacterium tuberculosis H37Rv	887427
YP_177890.1	CDS	dhaA	NC_000962.2	2903639	2904541	D	catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase	2903639..2904541	Mycobacterium tuberculosis H37Rv	888599
NP_217096.1	CDS	hisS	NC_000962.2	2904821	2906092	R	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase	complement(2904821..2906092)	Mycobacterium tuberculosis H37Rv	887479
NP_217097.1	CDS	Rv2581c	NC_000962.2	2906089	2906763	R	Rv2581c, (MTCY227.20), len: 224 aa. Possible glyoxalase II (EC 3.1.2.6), equivalent to Q49649|YP81_MYCLE|ML0493|MLCB1259.11|B1177_C3_247 HYPOTHETICAL 23.9 KDA PROTEIN from Mycobacterium leprae (218 aa), FASTA scores: opt: 1264, E(): 7.8e-73, (82.0% identity in 222 aa overlap). Also highly similar to Q9KXP1|SC9C5.33c POSSIBLE HYDROLASE from Streptomyces coelicolor (235 aa), FASTA scores: opt: 654, E(): 2.9e-34, (46.8% identity in 220 aa overlap); and similar to Q9CI24|YFCI HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (210 aa), FASTA scores: opt: 360, E(): 9.9e-16, (35.0% identity in 217 aa overlap); AAK75726|SP1646 METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN from Streptococcus pneumoniae (209 aa), FASTA scores: opt: 320, E(): 3.3e-13, (35.85% identity in 198 aa overlap); AAK80229|CAC2272 PREDICTED ZN-DEPENDENT HYDROLASE OF METALLO-BETA-LACTAMASE SUPERFAMILY from Clostridium acetobutylicum (199 aa), FASTA scores: opt: 282, E(): 8e-11, (32.7% identity in 217 aa overlap); etc. Equivalent to AAK46971 from Mycobacterium tuberculosis strain CDC1551 (246 aa) but shorter 22 aa. BELONGS TO THE GLYOXALASE II FAMILY. COFACTOR: BINDS TWO ZINC IONS.; glyoxalase II	complement(2906089..2906763)	Mycobacterium tuberculosis H37Rv	888217
NP_217098.1	CDS	ppiB	NC_000962.2	2906814	2907740	D	Rv2582, (MTCY227.19c), len: 308 aa. Probable ppiB (alternate gene name: ppi), cyclophilin (peptidyl-prolyl cis-trans isomerase) (EC 5.2.1.8), equivalent to P46697|PPIB_MYCLE|PPI|ML0492|MLCB1259.10c|B1177_F3_97 PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B from Mycobacterium leprae (295 aa), FASTA scores: opt: 1423, E(): 1.3e-66, (72.2% identity in 295 aa overlap). Aldo similar to others e.g. Q9KJG8|PPIB PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Streptomyces lividans (277 aa), FASTA scores: opt: 485, E(): 3.2e-18, (38.35% identity in 292 aa overlap); Q9KXP0|SC9C5.34 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Streptomyces coelicolor (277 aa), FASTA scores: opt: 483, E(): 4.1e-18, (38.35% identity in 292 aa overlap); Q9RT72|DR1893 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE from Deinococcus radiodurans (350 aa), FASTA scores: opt: 296, E(): 2.2e-08, (29.0% identity in 276 aa overlap); etc. BELONGS TO THE CYCLOPHILIN-TYPE PPIASE FAMILY.; ppi; peptidyl-prolyl cis-trans isomerase B	2906814..2907740	Mycobacterium tuberculosis H37Rv	887691
NP_217099.1	CDS	relA	NC_000962.2	2907826	2910198	R	Rv2583c, (MTCY227.18), len: 790 aa. Probable relA, GTP pyrophosphokinase (EC 2.7.6.5), equivalent to Q49640|RELA_MYCLE|ML0491|MLCB1259.09|B1177_C1_168 PROBABLE GTP PYROPHOSPHOKINASE from Mycobacterium leprae (787 aa), FASTA scores: opt: 4834, E(): 0, (93.4% identity in 790 aa overlap). Also highly similar to others e.g. O87331|RELA_CORGL|RELA|REL from Corynebacterium glutamicum (Brevibacterium flavum) (760 aa), FASTA scores: opt: 3375, E(): 1.6e-196, (67.0% identity in 758 aa overlap); O85709|RELA_STRAT from Streptomyces antibioticus (841 aa), FASTA scores: opt: 3209, E(): 1.9e-186, (63.85% identity in 786 aa overlap); Q9KDH1|RELA|BH1242 from Bacillus halodurans (728 aa), FASTA scores: opt: 2195,E(): 3.8e-125, (45.65% identity in 714 aa overlap); etc. BELONGS TO THE RELA / SPOT FAMILY.; GTP pyrophosphokinase	complement(2907826..2910198)	Mycobacterium tuberculosis H37Rv	887888
NP_217100.1	CDS	apt	NC_000962.2	2910229	2910900	R	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase	complement(2910229..2910900)	Mycobacterium tuberculosis H37Rv	888579
NP_217101.1	CDS	Rv2585c	NC_000962.2	2911004	2912677	R	Rv2585c, (MT2662, MTCY227.16), len: 557 aa. Possible conserved lipoprotein precursor, possibly attached to the membrane by a lipid anchor and substrate-binding protein involved in transport, equivalent to Q49646|YP85_MYCLE|ML0489|MLCB1259.07|B1177_C2_197 HYPOTHETICAL LIPOPROTEIN PRECURSOR from Mycobacterium leprae (555 aa), FASTA scores: opt: 2812, E(): 9.8e-158, (78.95% identity in 546 aa overlap); and C-terminus highly similar to C-terminus of Q49638|DCIAE|B1177_C1_166 DCIAE PROTEIN from Mycobacterium leprae (344 aa), FASTA scores: opt: 1177, E(): 7.4e-62, (78.6% identity in 229 aa overlap). Also similar in part to various proteins, principally substrate-binding proteins, e.g. O87329|DCIAE DIPEPTIDE-BINDING PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (502 aa), FASTA scores: opt: 614, E(): 1.2e-28, (30.7% identity in 427 aa overlap); Q9AKR0|OPPA|CAC49261 PUTATIVE OLIGOPEPTIDE UPTAKE ABC TRANSPORTER PERIPLASMIC SOLUTE-BINDING PROTEIN PRECURSOR from Rhizobium meliloti (Sinorhizobium meliloti) (532 aa), FASTA scores: opt: 209, E(): 7.7e-05, (22.85% identity in 460 aa overlap); P76128|YDDS_ECOLI|B1487|P77769|P76874 PUTATIVE ABC TRANSPORTER PERIPLASMIC BINDING PROTEIN from Escherichia coli strain K12 (516 aa), FASTA scores: opt: 182, E(): 0.0029, (20.0% identity in 315 aa overlap); etc.; lipoprotein	complement(2911004..2912677)	Mycobacterium tuberculosis H37Rv	887701
NP_217102.1	CDS	secF	NC_000962.2	2912683	2914011	R	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF	complement(2912683..2914011)	Mycobacterium tuberculosis H37Rv	887229
NP_217103.1	CDS	secD	NC_000962.2	2914015	2915736	R	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD	complement(2914015..2915736)	Mycobacterium tuberculosis H37Rv	888192
NP_217104.1	CDS	yajC	NC_000962.2	2915846	2916193	R	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC	complement(2915846..2916193)	Mycobacterium tuberculosis H37Rv	887346
NP_217105.1	CDS	gabT	NC_000962.2	2916360	2917709	D	catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase	2916360..2917709	Mycobacterium tuberculosis H37Rv	887915
NP_217106.1	CDS	fadD9	NC_000962.2	2917871	2921377	D	Rv2590, (MTCY227.11c), len: 1168 aa. Probable fadD9, fatty-acid-CoA synthetase (EC 6.2.1.-), highly similar to O69484|FADD9 (alias Q9CCT4|FADD9|ML0484 but longer 14 aa) PUTATIVE ACYL-CoA SYNTHETASE from Mycobacterium leprae (1174 aa), FASTA scores: opt: 5247, E(): 0, (68.0% identity in 1178 aa overlap); Q49651|LCLA|B1177_F1_23 PUTATIVE LONG-CHAIN-FATTY-ACID--CoA LIGASE from Mycobacterium leprae (827 aa), FASTA scores: opt: 3170, E(): 7.1e-181, (63.9% identity in 770 aa overlap). N-terminal (700 residues) similar to other long chain fatty acid ligases. And C-terminus highly similar to C-terminus of Q9XCF2|PSTB PSTB PROTEIN from Mycobacterium avium (2552 aa), FASTA scores: opt: 2083, E(): 8.4e-116, (40.8% identity in 1150 aa overlap) (and weak similarity on N-terminus); Q49653|POL1|B1177_F2_70 POL1 PROTEIN from Mycobacterium leprae (400 aa), FASTA scores: opt: 2066, E(): 2e-115, (76.25% identity in 404 aa overlap). C-terminal part highly similar to polyketide synthases and peptides synthases (weak similarity on N-terminus) e.g. Q10896|Rv0101|MTCY251.20|NRP PROBABLE PEPTIDE SYNTHETASE from Mycobacterium tuberculosis (2512 aa), FASTA scores: opt: 1988, E(): 3.7e-110, (40.2% identity in 1181 aa overlap); etc. Contains PS00455 putative AMP-binding domain signature, and PS00061 Short-chain alcohol dehydrogenase family signature. SEEMS TO BELONG TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY, AND TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; fatty-acid-CoA ligase	2917871..2921377	Mycobacterium tuberculosis H37Rv	888574
YP_177891.1	CDS	PE_PGRS44	NC_000962.2	2921551	2923182	D	Rv2591, (MTCY227.10c), len: 543 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to others e.g. O53845|Rv0834c|MTV043.26c from Mycobacterium tuberculosis (882 aa), FASTA scores: opt: 1813, E(): 5.8e-66, (55.3% identity in 568 aa overlap). Equivalent to AAK46982 from Mycobacterium tuberculosis strain CDC1551 (505 aa) but longer 38 aa. Contains PS00583 pfkB family of carbohydrate kinases signature 1.; PE-PGRS family protein	2921551..2923182	Mycobacterium tuberculosis H37Rv	887992
NP_217108.1	CDS	ruvB	NC_000962.2	2923199	2924233	R	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB	complement(2923199..2924233)	Mycobacterium tuberculosis H37Rv	888173
NP_217109.1	CDS	ruvA	NC_000962.2	2924230	2924820	R	plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA	complement(2924230..2924820)	Mycobacterium tuberculosis H37Rv	887688
NP_217110.1	CDS	ruvC	NC_000962.2	2924817	2925383	R	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase	complement(2924817..2925383)	Mycobacterium tuberculosis H37Rv	887418
NP_217111.1	CDS	Rv2595	NC_000962.2	2925492	2925737	D	Rv2595, (MTCY227.06c), len: 81 aa. Conserved hypothetical protein, showing similarity with various bacterial proteins e.g. O28268|AF2011 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (86 aa), FASTA scores: opt: 120, E(): 0.13, (34.35% identity in 67 aa overlap); CAC46196|SMC01176 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (79 aa), FASTA scores: opt: 119, E(): 0.14, (33.35% identity in 63 aa overlap); P37554|SP5T_BACSU|SPOVT STAGE V SPORULATION PROTEIN T from Bacillus subtilis (178 aa), FASTA scores: opt: 104, E(): 2.9, (51.45% identity in 35 aa overlap); etc. Also similar to O07779|Rv0599c|MTCY19H5.23 hypothetical protein from Mycobacterium tuberculosis (78 aa), FASTA scores: opt: 160, E(): 0.00026, (35.8% identity in 81 aa overlap).; hypothetical protein	2925492..2925737	Mycobacterium tuberculosis H37Rv	887682
NP_217112.1	CDS	Rv2596	NC_000962.2	2925734	2926138	D	Rv2596, (MTCY227.05c), len: 134 aa. Conserved hypothetical protein, similar to O07780|Rv0598c|MTCY19H5.24 HYPOTHETICAL 14.8 KDA PROTEIN from Mycobacterium tuberculosis (137 aa), FASTA scores: opt: 254, E(): 8.8e-11, (41.55% identity in 130 aa overlap).; hypothetical protein	2925734..2926138	Mycobacterium tuberculosis H37Rv	888218
NP_217113.1	CDS	Rv2597	NC_000962.2	2926355	2926975	D	Rv2597, (MTCY227.04c), len: 206 aa. Probable membrane protein.; hypothetical protein	2926355..2926975	Mycobacterium tuberculosis H37Rv	887679
NP_217114.1	CDS	Rv2598	NC_000962.2	2926986	2927480	D	Rv2598, (MTCY227.03c), len: 164 aa. Conserved hypothetical protein, showing similarity with hypothetical proteins from Streptomyces coelicolor e.g. Q9X8S3|SCH10.34c (185 aa), FASTA scores: opt: 197, E(): 3.5e-06, (34.75% identity in 167 aa overlap); and Q9L088|SCC24.29c (172 aa), FASTA scores: opt: 149, E(): 0.0053, (37.65% identity in 146 aa overlap). Equivalent to AAK46988 from Mycobacterium tuberculosis strain CDC1551 (154 aa) but longer 10 aa.; hypothetical protein	2926986..2927480	Mycobacterium tuberculosis H37Rv	887689
NP_217115.1	CDS	Rv2599	NC_000962.2	2927477	2927908	D	Rv2599, (MTCY227.02c), len: 143 aa. Probable conserved membrane protein, equivalent to Q9K536|2599 HYPOTHETICAL 15.0 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (143 aa), FASTA scores: opt: 691, E(): 1.7e-33, (68.55% identity in 143 aa overlap). Shows weak similarity with Q9L089|SCC24.28c PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (131 aa), FASTA scores: opt: 130, E(): 0.52, (26.45% identity in 136 aa overlap). Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.; hypothetical protein	2927477..2927908	Mycobacterium tuberculosis H37Rv	887832
NP_217116.1	CDS	Rv2600	NC_000962.2	2927990	2928391	D	Rv2600, (MTCY277.01c, MTV001.01), len: 133 aa. Probable conserved integral membrane protein, equivalent (but shorter 18 aa) to Q9K537|YQ00_MYCPA HYPOTHETICAL PROTEIN RV2600 HOMOLOG from Mycobacterium paratuberculosis (151 aa), FASTA scores: opt: 543, E(): 4.2e-28, (62.9% identity in 132 aa overlap). Also some similarity with other hypothetical or membrane proteins e.g. Q9L090|SCC24.27c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (146 aa), FASTA scores: opt: 241, E(): 8.7e-09, (34.8% identity in 135 aa overlap); O58487|PH0773 HYPOTHETICAL 15.0 KDA PROTEIN from Pyrococcus horikoshii (138 aa), FASTA scores: opt: 116, E(): 0.84, (34.35% identity in 96 aa overlap); etc. Equivalent to AAK46990 from Mycobacterium tuberculosis strain CDC1551 (152 aa) but shorter 19 aa.; integral membrane protein	2927990..2928391	Mycobacterium tuberculosis H37Rv	887869
YP_177892.1	CDS	speE	NC_000962.2	2928388	2929959	D	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase	2928388..2929959	Mycobacterium tuberculosis H37Rv	887676
YP_177673.1	CDS	Rv2601A	NC_000962.2	2930070	2930357	D	Rv2601A, 95 aa. Hypothetical protein, showing few similarity to O53811|Rv0748 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (88 aa), FASTA scores: opt: 132, E(): 0.017, (29.25% identity in 82 aa overlap); O53218|Rv2493 (73 aa), FASTA scores: opt: 107, E(): 0.97, (33.75% identity in 83 aa overlap); and Q10799|YS71_MYCTU|Rv2871 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (85 aa), FASTA scores: opt: 108, E(): 0.91, (41.00% identity in 39 aa overlap).; hypothetical protein	2930070..2930357	Mycobacterium tuberculosis H37Rv	3205108
NP_217118.1	CDS	Rv2602	NC_000962.2	2930344	2930784	D	Rv2602, (MTCI270A.03c), len: 146 aa. Conserved hypothetical protein, some weak similarity with proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O50457|Rv1242|MTV006.14 (143 aa), FASTA scores: opt: 147, E(): 0.0021, (26.25% identity in 141 aa overlap); P95023|Rv2530c|MTCY159.26 (139 aa), FASTA scores: opt: 131, E(): 0.027, (33.35% identity in 135 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 125, E(): 0.072, (26.45% identity in 140 aa overlap).; hypothetical protein	2930344..2930784	Mycobacterium tuberculosis H37Rv	888186
NP_217119.1	CDS	Rv2603c	NC_000962.2	2930805	2931560	R	Rv2603c, (MTCI270A.02), len: 251 aa. Highly conserved hypothetical protein, equivalent to Q49645|YQ03_MYCLE|ML0475|U1177B|B1177_C2_181 HYPOTHETICAL 26.6 KDA PROTEIN from Mycobacterium leprae (251 aa), FASTA scores: opt: 1514, E(): 2.2e-84, (92.45% identity in 251 aa overlap). Also highly similar to Q9L288|SCL2.11c HYPOTHETICAL 26.8 KDA PROTEIN from Streptomyces coelicolor (250 aa), FASTA scores: opt: 1268, E(): 1.5e-69, (76.7% identity in 249 aa overlap); Q9AE12|YFCA HYPOTHETICAL STRUCTURAL PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (251 aa), FASTA scores: opt: 1231, E(): 2.6e-67, (72.9% identity in 251 aa overlap); O83487|Y474_TREPA|TP0474 HYPOTHETICAL PROTEIN from Treponema pallidum (245 aa), FASTA scores: opt: 780, E(): 4.4e-40, (47.75% identity in 245 aa overlap); P24237|YEBC_ECOLI|B1864 PROTEIN YEBC from Escherichia coli strain K12 (246 aa), FASTA scores: opt: 776, E(): 7.6e-40, (47.8% identity in 249 aa overlap); etc.; hypothetical protein	complement(2930805..2931560)	Mycobacterium tuberculosis H37Rv	887369
NP_217120.1	CDS	Rv2604c	NC_000962.2	2931693	2932289	R	with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT	complement(2931693..2932289)	Mycobacterium tuberculosis H37Rv	887371
NP_217121.1	CDS	tesB2	NC_000962.2	2932297	2933142	R	Rv2605c, (MTCY01A10.28), len: 281 aa. Probable tesB2, acyl-CoA thioesterase II (EC 3.1.2.-), highly similar to others e.g. Q98EG9|MLL4250 from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 563, E(): 3.9e-29, (47.75% identity in 287 aa overlap); CAC47767 from Rhizobium meliloti (Sinorhizobium meliloti) (294 aa), FASTA scores: opt: 553, E(): 1.8e-28, (49.3% identity in 280 aa overlap); P23911|TESB_ECOLI|B0452 from Escherichia coli strain K12 (285 aa), FASTA scores: opt: 487, E(): 3.1e-24, (41.9% identity in 277 aa overlap); etc. Also similar to O06135|TESB1|Rv1618|MTCY01B2.10 ACYL-CoA THIOESTERASE II from Mycobacterium tuberculosis (300 aa), FASTA scores: opt: 425, E(): 1.1e-21, (34.9% identity in 278 aa overlap). BELONGS TO THE C/M/P THIOESTER HYDROLASE FAMILY.; acyl-CoA thioesterase II	complement(2932297..2933142)	Mycobacterium tuberculosis H37Rv	887588
NP_217122.1	CDS	Rv2606c	NC_000962.2	2933171	2934070	R	with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS	complement(2933171..2934070)	Mycobacterium tuberculosis H37Rv	888592
NP_217123.1	CDS	pdxH	NC_000962.2	2934198	2934872	D	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase	2934198..2934872	Mycobacterium tuberculosis H37Rv	888155
YP_177893.1	CDS	PPE42	NC_000962.2	2935046	2936788	D	Rv2608, (MTCY01A10.25c), len: 580 aa. Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O06828|Rv1430|MTCY493.24c from Mycobacterium tuberculosis (528 aa), FASTA scores: opt: 1004, E(): 5.9e-48, (56.05% identity in 307 aa overlap).; PPE family protein	2935046..2936788	Mycobacterium tuberculosis H37Rv	888204
NP_217125.1	CDS	Rv2609c	NC_000962.2	2936810	2937865	R	Rv2609c, (MTCY01A10.24), len: 351 aa. Probable conserved membrane protein, equivalent to O07146|MLCL581.13c|ML0451 HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium leprae (349 aa), FASTA scores: opt: 1675, E(): 1.4e-95, (77.85% identity in 334 aa overlap). Also similar to hypothetical proteins: O69888|SC2E1.17|MUTT HYPOTHETICAL 19.4 KDA PROTEIN from Streptomyces coelicolor and Streptomyces lividans (172 aa), FASTA scores: opt: 345, E(): 3.5e-14, (44.7% identity in 161 aa overlap); Q9L285|SCL2.14c HYPOTHETICAL 19.8 KDA PROTEIN from Streptomyces coelicolor (180 aa), FASTA scores: opt: 179, E(): 0.00056, (43.25% identity in 171 aa overlap); and Q9RYE5|DR0004 MUTT/NUDIX FAMILY PROTEIN from Deinococcus radiodurans (350 aa), FASTA scores: opt: 153, E(): 0.037, (33.35% identity in 123 aa overlap). Contains PS00893 mutT domain signature. BELONGS TO THE MUTT/NUDIX FAMILY.; hypothetical protein	complement(2936810..2937865)	Mycobacterium tuberculosis H37Rv	888208
NP_217126.1	CDS	pimA	NC_000962.2	2937865	2939001	R	Rv2610c, (MTCY01A10.23), len: 378 aa. pimA, alpha-mannosyltransferase (EC 2.4.1.-) (see citations below), equivalent to O07147|MLCL581.14c|ML0452 PUTATIVE GLYCOSYLTRANSFERASE from Mycobacterium leprae (374 aa), FASTA scores: opt: 2044, E(): 8.8e-118, (82.25% identity in 378 aa overlap). N-terminus (from aa 1 to 27) equivalent to Q9FY7 PUTATIVE ALPHA-MANNOSYL TRANSFERASE (FRAGMENT) from Mycobacterium smegmatis (27 aa), BLASTP scores: 57.4 bits (137), E(): 3e-8, Identities = 25/27 (92%), Positives = 27/27 (99%) (see citation below). Also highly similar to Q9L284|SCL2.15c PUTATIVE SUGAR TRANSFERASE from Streptomyces coelicolor (387 aa), FASTA scores: opt: 1222, E(): 1.8e-67, (52.95% identity in 376 aa overlap); and similar in part to various proteins e.g. Q9YA73|APE2066 LONG HYPOTHETICAL N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN from Aeropyrum pernix (392 aa), FASTA scores: opt: 434, E(): 3e-19, (31.5% identity in 378 aa overlap); Q9UZA1|PAB0827 GALACTOSYLTRANSFERASE OR LPS BIOSYNTHESIS RFBU RELATED PROTEIN from Pyrococcus abyssi (371 aa), FASTA scores: opt: 382, E(): 4.3e-16, (28.2% identity in 383 aa overlap); O26275|MTH173 LPS BIOSYNTHESIS RFBU RELATED PROTEIN from Methanothermobacter thermautotrophicus (382 aa), FASTA scores: opt: 372, E(): 1.8e-15, (28.4% identity in 391 aa overlap); etc. Shows also some similarity with O05313|Rv1212c|MTCI364.24c HYPOTHETICAL 41.5 KDA PROTEIN from Mycobacterium tuberculosis (387 aa), FASTA scores: opt: 232, E(): 1.1e -07, (28.4% identity in 402 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; alpha-mannosyltransferase PIMA	complement(2937865..2939001)	Mycobacterium tuberculosis H37Rv	888627
NP_217127.1	CDS	Rv2611c	NC_000962.2	2939012	2939962	R	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase	complement(2939012..2939962)	Mycobacterium tuberculosis H37Rv	888618
YP_177894.1	CDS	pgsA1	NC_000962.2	2939959	2940612	R	Rv2612c, (MTCY01A10.21), len: 217 aa. Probable pgsA1 (previously known as pgsA), PI synthase/CDP-diacylglyceride--inositol phosphatidyltransferase (EC 2.7.8.11), transmembrane protein, equivalent to O07149|MLCL581.16c|PGSA|ML0454 PUTATIVE PHOSPHATIDYLTRANSFERASE from Mycobacterium leprae (239 aa), FASTA scores: opt: 1141, E(): 4.1e-70, (79.35% identity in 213 aa overlap); and Q9F7Y9|PGSA PHOSPHATIDYLINOSITOL SYNTHASE from Mycobacterium smegmatis (222 aa), FASTA scores: opt: 981, E(): 2.7e-59, (67.3% identity in 217 aa overlap) (see citation below). Also similar to other proteins e.g. Q9L282|SCL2.17c PUTATIVE MEMBRANE TRANSFERASE from Streptomyces coelicolor (241 aa), FASTA scores: opt: 564, E(): 4.9e-31, (43.4% identity in 212 aa overlap); Q9UYD0|PGSA-LIKE|PAB1041 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Pyrococcus abyssi (186 aa), FASTA scores: opt: 264, E(): 8.4e-11, (33.15% identity in 190 aa overlap); Q9HQS2|PGSA|VNG1030G CDP-DIACYLGLYCEROL-GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Halobacterium sp. strain NRC-1 (199 aa), FASTA scores: opt: 249, E(): 9.1e-10, (32.1% identity in 193 aa overlap); etc. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY. Note that in Mycobacterium smegmatis, the psgA homologue is essential to the survival of the bacteria and seems cannot be compensated by any other enzyme of Mycobacterium smegmatis.; pgsA; CDP-diacylglycerol--inositol 3-phosphatidyltransferase	complement(2939959..2940612)	Mycobacterium tuberculosis H37Rv	888209
NP_217129.1	CDS	Rv2613c	NC_000962.2	2940609	2941196	R	Rv2613c, (MTCY01A10.20A), len: 195 aa. Conserved hypothetical protein, equivalent to Q9CCU0|ML0455 HYPOTHETICAL PROTEIN from Mycobacterium leprae (206 aa), FASTA scores: opt: 1074, E(): 7.4e-62, (84.7% identity in 196 aa overlap); and highly similar, but longer 18 aa, to O07150|MLCL581.17c HYPOTHETICAL 20.7 KDA PROTEIN from Mycobacterium leprae (186 aa), FASTA scores: opt: 1038, E(): 1.4e-59, (89.7% identity in 175 aa overlap). Also highly similar to other hypothetical proteins (often Hit family member) e.g. Q9F7Z0 from Mycobacterium smegmatis (see citation below) (205 aa), FASTA scores: opt: 975, E(): 1.6e-55, (79.35% identity in 184 aa overlap); Q9L279|SCL2.20 from Streptomyces coelicolor (186 aa), FASTA scores: opt: 638, E(): 5.8e-34, (52.85% identity in 176 aa overlap); Q9YFX8|APE0122 from Aeropyrum pernix (184 aa), FASTA scores: opt: 515, E(): 4.4e-26, (45.9% identity in 159 aa overlap); etc. It seems the Rv2613c and downstream ORF Rv2612c|psgA1 are expressed from the same promoter (see citation below) and that Rv2613c should be involved in lipid metabolism.; hypothetical protein	complement(2940609..2941196)	Mycobacterium tuberculosis H37Rv	888193
NP_217130.1	CDS	thrS	NC_000962.2	2941189	2943267	R	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase	complement(2941189..2943267)	Mycobacterium tuberculosis H37Rv	888211
YP_177674.1	CDS	Rv2614A	NC_000962.2	2943376	2943603	D	Rv2614A, len: 75 aa. Conserved hypothetical protein. The region from aa 10-35 is similar to part of C-terminal part of several TRIOSEPHOSPHATE ISOMERASES (EC 5.3.1.1) e.g. P46711|TPIS_MYCLE|TPIA|TPI|ML0572|B1496_C1_127 from Mycobacterium leprae (261 aa), FASTA scores: opt: 112, E(): 0.95, (60.0% identity in 25 aa overlap); and O08408|TPIS_MYCTU|TPIA|TPI|Rv1438|MT1482|MTCY493.16c from Mycobacterium tuberculosis (261 aa), FASTA scores: opt: 104, E(): 3.3, (60.0% identity in 25 aa overlap); P19583|TPIS_CORGL|TPIA|TPI from Corynebacterium glutamicum (Brevibacterium flavum) (259 aa), FASTA scores: opt: 100, E(): 6, (45.45% identity in 33 aa overlap); etc. TRIOSEPHOSPHATE ISOMERASES PLAY AN IMPORTANT ROLE IN SEVERAL METABOLIC PATHWAYS (CATALYTIC ACTIVITY: D-GLYCERALDEHYDE 3-PHOSPHATE = DIHYDROXY-ACETONE PHOSPHATE).; hypothetical protein	2943376..2943603	Mycobacterium tuberculosis H37Rv	3205055
YP_177895.1	CDS	PE_PGRS45	NC_000962.2	2943600	2944985	R	Rv2615c, (MTCY01A10.19), len: 461 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to many e.g. P71664|Rv1396c|MTCY21B4.13c from Mycobacterium tuberculosis (576 aa), FASTA scores: opt: 1629, E(): 4.8e-58, (56.65% identity in 482 aa overlap). Equivalent to AAK47006 from Mycobacterium tuberculosis strain CDC1551 (476 aa) but shorter 15 aa.; PE-PGRS family protein	complement(2943600..2944985)	Mycobacterium tuberculosis H37Rv	888215
NP_217132.1	CDS	Rv2616	NC_000962.2	2945330	2945830	D	Rv2616, (MTCY01A10.18c), len: 166 aa. Conserved hypothetical protein, highly similar to bacterial proteins: Q9L1G0|SC3D11.02c HYPOTHETICAL 20.3 KDA PROTEIN from Streptomyces coelicolor (188 aa), FASTA scores: opt: 407, E(): 2.3e-20, (44.0% identity in 159 aa overlap); Q9X945 A3(2) GLYCOGEN METABOLISM CLUSTER from Streptomyces coelicolor (134 aa), FASTA scores: opt: 330, E(): 2.5e-15, (46.65% identity in 120 aa overlap) (N-terminus shorter); Q9RST8|DR2035 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (198 aa), FASTA scores: opt: 228, E(): 2.4e-08, (35.1% identity in 168 aa overlap).; hypothetical protein	2945330..2945830	Mycobacterium tuberculosis H37Rv	887289
NP_217133.1	CDS	Rv2617c	NC_000962.2	2945847	2946287	R	Rv2617c, (MTCY01A10.17), len: 146 aa. Probable transmembrane protein, showing some similarity to hypothetical or membrane proteins e.g. CAC47207|SMC00744 PUTATIVE TRANSPORT PROTEIN TRANSMEMBRANE from Rhizobium meliloti (Sinorhizobium meliloti) (399 aa), FASTA scores: opt: 108, E(): 5.5, (29.15% identity in 144 aa overlap).; hypothetical protein	complement(2945847..2946287)	Mycobacterium tuberculosis H37Rv	888610
NP_217134.1	CDS	Rv2618	NC_000962.2	2946434	2947111	D	Rv2618, (MTCY01A10.15c), len: 225 aa. Conserved hypothetical protein, similar in part to Q9EWQ9|SC4C2.03 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (159 aa), FASTA scores: opt: 235, E(): 1.3e-07, (43.7% identity in 103 aa overlap); Q9HLM6|TA0201 HYPOTHETICAL PROTEIN from Thermoplasma acidophilum (215 aa), FASTA scores: opt: 164, E(): 0.0038, (23.4% identity in 201 aa overlap); and to mycobacterial proteins e.g. O06191|Rv2621c|MTCY01A10.11 HYPOTHETICAL 24.2 KDA PROTEIN from Mycobacterium tuberculosis (224 aa), FASTA scores: opt: 149, E(): 0.033, (28.05% identity in 196 aa overlap).; hypothetical protein	2946434..2947111	Mycobacterium tuberculosis H37Rv	887690
NP_217135.1	CDS	Rv2619c	NC_000962.2	2947096	2947449	R	Rv2619c, (MTCY01A10.14), len: 117 aa. Conserved hypothetical protein, highly similar to Q9L0F3|SCD31.14 HYPOTHETICAL 11.6 KDA PROTEIN from Streptomyces coelicolor (110 aa) , FASTA scores: opt: 407, E(): 2.3e-21, (55.95% identity in 109 aa overlap). Also similarity with other short bacterial hypothetical proteins e.g. Q9F8B9 HYPOTHETICAL 12.4 KDA PROTEIN from Streptococcus agalactiae (112 aa), FASTA scores: opt: 143, E(): 0.0032, (32.45% identity in 74 aa overlap); etc.; hypothetical protein	complement(2947096..2947449)	Mycobacterium tuberculosis H37Rv	888601
NP_217136.1	CDS	Rv2620c	NC_000962.2	2947462	2947887	R	Rv2620c, (MTCY01A10.13), len: 141 aa. Probable conserved transmembrane protein, highly similar to O54184|SC7H1.25 HYPOTHETICAL 14.6 KDA PROTEIN from Streptomyces coelicolor (144 aa), FASTA scores: opt: 459, E(): 1.4e-22, (56.45% identity in 140 aa overlap).; transmembrane protein	complement(2947462..2947887)	Mycobacterium tuberculosis H37Rv	888497
NP_217137.1	CDS	Rv2621c	NC_000962.2	2947884	2948558	R	Rv2621c, (MTCY01A10.11), len: 224 aa. Possible transcriptional regulator, similar in part to Q49688|MLCL536.29c|ML0592 PUTATIVE DNA-BINDING PROTEIN from Mycobacterium leprae (254 aa), FASTA scores: opt: 168, E(): 0.0018, (29.75% identity in 222 aa overlap). Shows similarity with Q9XAD0|SCC22.08c PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (252 aa), FASTA scores: opt: 148, E(): 0.032, (29.4% identity in 204 aa overlap); and Q9RVM8|DR0999 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (225 aa), FASTA scores: opt: 195, E(): 3.3e-05, (29.6% identity in 213 aa overlap). Also some similarity with O06195|Rv2618|MTCY01A10.15c from Mycobacterium tuberculosis (225 aa), FASTA scores: opt: 149, E(): 0.025, (28.95% identity in 197 aa overlap). Contains helix-turn-helix motif at aa 31-52 (Score 1662, +4.85 SD).; transcriptional regulatory protein	complement(2947884..2948558)	Mycobacterium tuberculosis H37Rv	888565
NP_217138.1	CDS	Rv2622	NC_000962.2	2948636	2949457	D	Rv2622, (MTCY01A10.10c), len: 273 aa. Possible methyltransferase (EC 2.1.1.-), similar in part to others e.g. AAK75664|SP1578 PUTATIVE METHYLTRANSFERASE from Streptococcus pneumoniae (252 aa), FASTA scores: opt: 406, E(): 6.6e-18, (32.65% identity in 251 aa overlap); Q9F8B8 METHYLTRANSFERASE from Streptococcus agalactiae (254 aa), FASTA scores: opt: 381, E(): 2.3e-16, (31.75% identity in 252 aa overlap); Q9RJB6|SCF91.08 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (231 aa), FASTA scores: opt: 159, E(): 0.0091, (33.1% identity in 151 aa overlap); etc. Also similar in part to several hypothetical proteins e.g. Q99YR0|SPY1582 HYPOTHETICAL PROTEIN from Streptococcus pyogenes (251 aa), FASTA scores: opt: 397, E(): 2.3e-17, (36.3% identity in 248 aa overlap).; methyltransferase (methylase)	2948636..2949457	Mycobacterium tuberculosis H37Rv	887825
NP_217139.1	CDS	TB31.7	NC_000962.2	2949593	2950486	D	Rv2623, (MTCY01A10.09c), len: 297 aa. TB31.7, conserved hypothetical protein, highly similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.12 (295 aa), FASTA scores: opt: 1076, E(): 1.4e-60, (55.25% identity in 295 aa overlap); O53472|Rv2026c|MTV018.13c (294 aa), FASTA scores: opt: 988, E(): 4.8e-55, (51.5% identity in 295 aa overlap); Q10862|YJ96_MYCTU|Rv1996|MT2052|MTCY39.23c (317 aa), FASTA scores: opt: 688, E(): 4.1e-36, (45.1% identity in 315 aa overlap); etc. Also similar to several Streptomyces proteins e.g. Q9RIZ8|SCJ1.16c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (294 aa), FASTA scores: opt: 407, E(): 2e-18, (32.65% identity in 303 aa overlap); and other bacterial hypothetical proteins e.g. Q9HPP5|VNG1536 from Halobacterium sp (147 aa), FASTA scores: opt: 180, E(): 0.00022, (31.65% identity in 139 aa overlap).; hypothetical protein	2949593..2950486	Mycobacterium tuberculosis H37Rv	887442
NP_217140.1	CDS	Rv2624c	NC_000962.2	2950489	2951307	R	Rv2624c, (MTCY01A10.08), len: 272 aa. Conserved hypothetical protein, similar to several Streptomyces proteins e.g. Q9RIY5|SCJ1.29c HYPOTHETICAL 30.1 KDA PROTEIN from Streptomyces coelicolor (283 aa), FASTA scores: opt: 260, E(): 5e-09, (32.05% identity in 290 aa overlap). Also similar to Mycobacterium tuberculosis proteins O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt: 563, E(): 7e-28, (36.85% identity in 266 aa overlap); P95192|Rv3134c|MTCY03A2.240 (268 aa), FASTA scores: opt: 458, E(): 2.3e-21, (36.55% identity in 271 aa overlap); Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.12 (295 aa), FASTA scores: opt: 199, E(): 3.2e-05, (29.35% identity in 286 aa overlap); etc.; hypothetical protein	complement(2950489..2951307)	Mycobacterium tuberculosis H37Rv	888939
NP_217141.1	CDS	Rv2625c	NC_000962.2	2951322	2952503	R	Rv2625c, (MTCY01A10.07), len: 393 aa. Probable conserved transmembrane ala-, leu-rich protein, similar to many hypothetical or membrane proteins e.g. Q55518|Y528_SYNY3|SLL0528 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 (379 aa), FASTA scores: opt: 552, E(): 5.6e-26, (30.75% identity in 374 aa overlap); Q9RJ56|SCI41.35c HYPOTHETICAL 39.8 KDA PROTEIN from Streptomyces coelicolor (374 aa), FASTA scores: opt: 419, E(): 5.7e-18, (31.6% identity in 383 aa overlap); CAC49448|SMB20925 CONSERVED HYPOTHETICAL MEMBRANE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (372 aa), FASTA scores: opt: 401, E(): 6.9e-17, (29.5% identity in 383 aa overlap); etc. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.; hypothetical protein	complement(2951322..2952503)	Mycobacterium tuberculosis H37Rv	887692
NP_217142.1	CDS	Rv2626c	NC_000962.2	2952562	2952993	R	Rv2626c, (MTCY01A10.06), len: 143 aa. Conserved hypothetical protein, similar to CAC49670|SMB21441 PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE PROTEIN (EC 1.1.1.205) from Rhizobium meliloti (Sinorhizobium meliloti) (120 aa), FASTA scores: opt: 287, E(): 6.6e-12, (43.75% identity in 112 aa overlap) (has its N-terminus shorter 27 aa); AAK78655|CAC0678 CBS DOMAINS from Clostridium acetobutylicum (142 aa), FASTA scores: opt: 276, E(): 3.9e-11, (35.65% identity in 115 aa overlap); Q9K9P0|BH2605 BH2605 PROTEIN from Bacillus halodurans (142 aa), FASTA scores: opt: 276, E(): 3.9e-11, (35.65% identity in 115 aa overlap); etc. Also some similarity to P71737|Rv2406c|MTCY253.14 HYPOTHETICAL 15.1 KDA PROTEIN from Mycobacterium tuberculosis (142 aa), FASTA scores: opt: 145, E(): 0.00012, (22.3% identity in 112 aa overlap).; hypothetical protein	complement(2952562..2952993)	Mycobacterium tuberculosis H37Rv	888576
NP_217143.1	CDS	Rv2627c	NC_000962.2	2953507	2954748	R	Rv2627c, (MTCY01A10.05), len: 413 aa. Conserved hypothetical protein. Some similarity in C-terminal part of O53697|Rv0293c|MTV035.21c HYPOTHETICAL 44.0 KDA PROTEIN from Mycobacterium tuberculosis (400 aa), FASTA scores: opt: 392, E(): 1.9e-17, (31.1% identity in 299 aa overlap).; hypothetical protein	complement(2953507..2954748)	Mycobacterium tuberculosis H37Rv	888568
NP_217144.1	CDS	Rv2628	NC_000962.2	2955058	2955420	D	Rv2628, (MTCY01A10.04c), len: 120 aa. Hypothetical unknown protein.; hypothetical protein	2955058..2955420	Mycobacterium tuberculosis H37Rv	888566
NP_217145.1	CDS	Rv2629	NC_000962.2	2955767	2956891	D	Rv2629, (MTCY01A10.03c), len: 374 aa. Conserved hypothetical protein, similar to Q9ZC00|SC1E6.22c HYPOTHETICAL 40.7 KDA PROTEIN from Streptomyces coelicolor (373 aa), FASTA scores: opt: 425, E(): 2.5e-18, (30.2% identity in 371 aa overlap).; hypothetical protein	2955767..2956891	Mycobacterium tuberculosis H37Rv	888588
NP_217146.1	CDS	Rv2630	NC_000962.2	2956893	2957432	D	Rv2630, (MTCY01A10.02c), len: 179 aa. Hypothetical unknown protein.; hypothetical protein	2956893..2957432	Mycobacterium tuberculosis H37Rv	887426
NP_217147.2	CDS	Rv2631	NC_000962.2	2957572	2958870	D	Rv2631, (MTCY441.01, MTCY01A10.01c), len: 432 aa. Conserved hypothetical protein, highly similar to several conserved hypothetical proteins from various species e.g. O29399|AF0862 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (482 aa), FASTA scores: opt: 1496, E(): 2.1e-80, (52.3% identity in 432 aa overlap) (has its N-terminus longer 30 aa); O27634|MTH1597 CONSERVED PROTEIN from Methanothermobacter thermautotrophicus (488 aa), FASTA scores: opt: 1428, E(): 2.1e-76, (50.9% identity in 432 aa overlap); Q9YB37|APE1758 HYPOTHETICAL 53.7 KDA PROTEIN APE1758 from Aeropyrum pernix (483 aa), FASTA scores: opt: 1422, E(): 4.6e-76, (49.3% identity in 432 aa overlap) (has its N-terminus longer 30 aa); etc. Equivalent to AAK47022 from Mycobacterium tuberculosis strain CDC1551 (432 aa). 3' part extended since first submission (+175 aa).; hypothetical protein	2957572..2958870	Mycobacterium tuberculosis H37Rv	887431
NP_217148.1	CDS	Rv2632c	NC_000962.2	2958909	2959190	R	Rv2632c, (MTCY441.02c), len: 93 aa. Conserved hypothetical protein, highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis: P71996|YH38_MYCTU|Rv1738|MT1780|MTCY04C12.23 (94 aa), FASTA scores: opt: 319, E(): 4.2e-15, (53.95% identity in 89 aa overlap); and Q9KK61 from Mycobacterium bovis BCG (56 aa), FASTA scores: opt: 178, E(): 9.2e-06, (52.95% identity in 51 aa overlap).; hypothetical protein	complement(2958909..2959190)	Mycobacterium tuberculosis H37Rv	887231
NP_217149.1	CDS	Rv2633c	NC_000962.2	2959335	2959820	R	Rv2633c, (MTCY441.03c), len: 161 aa. Hypothetical unknown protein.; hypothetical protein	complement(2959335..2959820)	Mycobacterium tuberculosis H37Rv	888597
YP_177896.1	CDS	PE_PGRS46	NC_000962.2	2960105	2962441	R	Rv2634c, (MTCY441.04c), len: 778 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to many e.g. O53553|YZ08_MYCTU|Rv3508|MTV023.15 from Mycobacterium tuberculosis (1901 aa), FASTA scores: opt: 2553, E(): 2.2e-93, (53.8% identity in 866 aa overlap). Equivalent to AAK47026 from Mycobacterium tuberculosis strain CDC1551 (788 aa) but shorter 10 aa.; PE-PGRS family protein	complement(2960105..2962441)	Mycobacterium tuberculosis H37Rv	888573
NP_217151.1	CDS	Rv2635	NC_000962.2	2962470	2962712	D	Rv2635, (MTCY441.05), len: 80 aa. Hypothetical unknown protein.; hypothetical protein	2962470..2962712	Mycobacterium tuberculosis H37Rv	887813
NP_217152.1	CDS	Rv2636	NC_000962.2	2962713	2963390	D	Rv2636, (MTCY441.06), len: 225 aa. Conserved hypothetical protein, showing some similarity with various proteins: Q98FG2|MLL3789 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (239 aa), FASTA scores: opt: 304, E(): 3.7e-13, (31.55% identity in 187 aa overlap); CAC46568|SMC04451 PUTATIVE CHLORAMPHENICOL PHOSPHOTRANSFERASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (220 aa), FASTA scores: opt: 175, E(): 0.00014, (28.0% identity in 225 aa overlap); Q56148|CPT_STRVL CHLORAMPHENICOL 3-O PHOSPHOTRANSFERASE (EC 2.7.1.-) from Streptomyces violaceus (Streptomyces venezuelae) (178 aa), FASTA scores: opt: 131, E(): 0.1, (31.75% identity in 170 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Translational start site uncertain, chosen by similarity.; hypothetical protein	2962713..2963390	Mycobacterium tuberculosis H37Rv	888196
NP_217153.1	CDS	dedA	NC_000962.2	2963586	2964242	D	Rv2637, (MTCY441.07), len: 218 aa. Possible dedA, transmembrane protein, equivalent to Q49642|YQ37_MYCLE|ML0467|MLCL581.27|B1177_C2_172/B1177_C1 _1 40 HYPOTHETICAL 23.1 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN, BELONGS TO THE DEDA FAMILY) from Mycobacterium leprae (214 aa), FASTA scores: opt: 1160, E(): 4.4e-64, (82.75% identity in 209 aa overlap); and O69601|Y364_MYCLE|ML0287|MLCB4.30 HYPOTHETICAL PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) (222 aa), FASTA scores: opt: 292, E(): 6.6e-11, (32.25% identity in 189 aa overlap). Also highly similar to other membrane proteins e.g. CAC42863|SCBAC36F5.27c PUTATIVE INTEGRAL MEMBRANE from Streptomyces coelicolor (211 aa), FASTA scores: opt: 837, E(): 2.6e-44, (59.2% identity in 201 aa overlap); Q55705|Y232_SYNY3|SLR0232 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 (218 aa), FASTA scores: opt: 415, E(): 1.9e-18, (37.85% identity in 206 aa overlap); Q9RV63|DR1167 DEDA PROTEIN from Deinococcus radiodurans (200 aa); P09548|DEDA_ECOLI|B2317|Z3579|ECS3201 DEDA PROTEIN (DSG-1 PROTEIN) from Escherichia coli strains K12 and O157:H7 (219 aa), BLAST scores: 178, E(): 1.8e-13, Identities = 53/175 (30%); etc. Also similar to O06314|Y364_MYCTU|Rv0364|MT0380|MTCY13E10.26 HYPOTHETICAL 24.5 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Mycobacterium tuberculosis (227 aa), FASTA scores: opt: 293, E(): 5.8e-11, (35.85% identity in 184 aa overlap). BELONGS TO THE DEDA FAMILY.; transmembrane protein DedA	2963586..2964242	Mycobacterium tuberculosis H37Rv	888616
NP_217154.1	CDS	Rv2638	NC_000962.2	2964405	2964851	D	Rv2638, (MTCY441.08), len: 147 aa. Conserved hypothetical protein, similar in part to Q9WVX8|RSBV_STRCO|BLDG|SCH5.12c ANTI-SIGMA B FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa), FASTA scores: opt: 162, E(): 0.00066, (31.8% identity in 110 aa overlap); and showing weak similarity with various proteins e.g. O69205 HYPOTHETICAL 13.4 KDA PROTEIN from Actinosynnema pretiosum (subsp. auranticum) (128 aa), FASTA scores: opt: 157, E(): 0.0016, (29.8% identity in 114 aa overlap); Q9RJ93|SCF91.32 PUTATIVE ANTI-SIGMA FACTOR ANTAGONIST from Streptomyces coelicolor (183 aa), FASTA scores: opt: 148, E(): 0.0082, (30.85% identity in 107 aa overlap); etc. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis: O07728|Rv1904|MTCY180.14c (143 aa), FASTA scores: opt: 456, E(): 3.9e-23, (52.8% identity in 125 aa overlap); and Q11035|YD65_MYCTU|Rv1365c|MT1411|MTCY02B10.29c (128 aa), FASTA scores: opt: 435, E(): 8.6e-22, (53.6% identity in 125 aa overlap).; hypothetical protein	2964405..2964851	Mycobacterium tuberculosis H37Rv	888156
NP_217155.1	CDS	Rv2639c	NC_000962.2	2965026	2965358	R	Rv2639c, (MTCY441.09c), len: 110 aa. Probable conserved integral membrane protein, highly similar to many bacterial hypothetical or membrane proteins e.g. Q9X889|YE14_STRCO|SCE15.14 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 597, E(): 3.1e-31, (73.15% identity in 108 aa overlap); Q55939|Y793_SYNY3|SLL0793 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 (108 aa), FASTA scores: opt: 341, E(): 4.9e-15, (51.4% identity in 109 aa overlap); O31553|YFJF_BACSU POTENTIAL INTEGRAL MEMBRANE PROTEIN from Bacillus subtilis (109 aa), FASTA scores: opt: 334, E(): 1.4e-14, (47.5% identity in 109 aa overlap); etc.; hypothetical protein	complement(2965026..2965358)	Mycobacterium tuberculosis H37Rv	887428
NP_217156.1	CDS	Rv2640c	NC_000962.2	2965478	2965837	R	Rv2640c, (MTCY441.10c), len: 119 aa. Possible transcriptional regulator, arsR family, highly similar to many e.g. Q9L1V5|SC4A9.07 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (117 aa), FASTA scores: opt: 261, E(): 5.6e-10, (47.75% identity in 103 aa overlap); Q9X8X8|SCH35.28c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (122 aa), FASTA scores: opt: 252, E(): 2.2e-09, (37.05% identity in 116 aa overlap); Q9L220|SC1A2.21 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (119 aa), FASTA scores: opt: 252, E(): 2.2e-09, (37.05% identity in 116 aa overlap); P77295|YGAV_ECOLI|B2667 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli strain K12 (99 aa), FASTA scores: opt: 156, E(): 0.0023, (34.1% identity in 88 aa overlap); etc. Also similar to upstream ORF P71941|Rv2642|MTCY441.12 PUTATIVE TRANSCRIPTIONAL REGULATORY PROTEIN from Mycobacterium tuberculosis (126 aa), FASTA scores: opt: 237, E(): 2e-08, (38.55% identity in 109 aa overlap). Contains helix-turn-helix motif at aa 59-80 (Score 1166, +3.16 SD). BELONGS TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS.; ArsR family transcriptional regulator	complement(2965478..2965837)	Mycobacterium tuberculosis H37Rv	888594
NP_217157.1	CDS	cadI	NC_000962.2	2965939	2966397	D	Rv2641, (MTCY441.11), len: 152 aa. cadI, conserved hypothetical protein. Gene induced by cadmium (see Hotter et al., 2001), highly similar to hypothetical proteins e.g. Q9L222|SC1A2.19c from Streptomyces coelicolor (152 aa), FASTA scores: opt: 509, E(): 2.3e-27, (55.05% identity in 149 aa overlap); P45945|YQCK_BACSU from Bacillus subtilis (146 aa), FASTA scores: opt: 295, E(): 5.4e-13, (33.55% identity in 146 aa overlap); and Q98CF8|MLL5167 from Rhizobium loti (Mesorhizobium loti) (124 aa), FASTA scores: opt: 110, E(): 1.3, (31.4% identity in 121 aa overlap). Some similarity with Q10548|Y887_MYCTU|Rv0887c|MT0910|MTCY31.15c from Mycobacterium tuberculosis (152 aa), FASTA scores: opt: 108, E(): 2.1, (25.7% identity in 148 aa overlap).; cadmium inducible protein CADI	2965939..2966397	Mycobacterium tuberculosis H37Rv	888629
NP_217158.1	CDS	Rv2642	NC_000962.2	2966533	2966913	D	Rv2642, (MTCY441.12), len: 126 aa. Possible transcriptional regulator, arsR family, highly similar to many e.g. Q9X8X8|SCH35.28c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (122 aa), FASTA scores: opt: 390, E(): 3.7e-19, (56.55% identity in 122 aa overlap); Q9L220|SC1A2.21 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (119 aa), FASTA scores: opt: 378, E(): 2.3e-18, (59.8% identity in 97 aa overlap); Q9L1V5|SC4A9.07 PUTATIVE ARSR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (117 aa), FASTA scores: opt: 359, E(): 4.1e-17, (56.9% identity in 116 aa overlap); P52144|ARR2_ECOLI|ARSR from Escherichia coli (117 aa), FASTA scores: opt: 202, E(): 1e-06, (39.8% identity in 88 aa overlap); etc. Also similar to downstream ORF P71939|Rv2640c|MTCY441.10c PUTATIVE TRANSCRIPTIONAL REGULATORY PROTEIN from Mycobacterium tuberculosis (119 aa), FASTA scores: opt: 237, E(): 5e-09, (38.55% identity in 109 aa overlap); and others from Mycobacterium tuberculosis e.g. O05840|Rv2358|MTCY27.22c. Contains PS00846 Bacterial regulatory proteins, arsR family signature. Contains helix-turn-helix motif at aa 58-79 (Score 1112, +2.97 SD). BELONGS TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS.; ArsR family transcriptional regulator	2966533..2966913	Mycobacterium tuberculosis H37Rv	887703
NP_217159.1	CDS	arsC	NC_000962.2	2966910	2968406	D	Rv2643, (MTCY441.13), len: 498 aa. Probable arsC, arsenical resistance transport integral membrane protein, highly similar or similar to others e.g. Q9L1X4|SC3D9.05 POSSIBLE ARSENIC RESISTANCE MEMBRANE TRANSPORT PROTEIN from Streptomyces coelicolor (368 aa), FASTA scores: opt: 1729, E(): 2.2e-96, (74.3% identity in 358 aa overlap); Q9X8Y0|SCH35.26 PUTATIVE HEAVY METAL RESISTANCE MEMBRANE PROTEIN from Streptomyces coelicolor (369 aa), FASTA scores: opt: 1729, E(): 2.2e-96, (73.8% identity in 359 aa overlap); Q06598|ACR3_YEAST|ACR3|YPR201W|P9677.2 ARSENICAL-RESISTANCE PROTEIN from Saccharomyces cerevisiae (Baker's yeast) (404 aa), FASTA scores: opt: 591, E(): 4e-28, (36.6% identity in 380 aa overlap); etc. BELONGS TO THE ACR3 FAMILY.; arsenic-transport integral membrane protein ArsC	2966910..2968406	Mycobacterium tuberculosis H37Rv	887674
NP_217160.1	CDS	Rv2644c	NC_000962.2	2968533	2968850	R	Rv2644c, (MTCY441.14c), len: 105 aa. Hypothetical unknown protein.; hypothetical protein	complement(2968533..2968850)	Mycobacterium tuberculosis H37Rv	887366
NP_217161.1	CDS	Rv2645	NC_000962.2	2970123	2970554	D	Rv2645, (MTCY441.15), len: 143 aa. Hypothetical unknown protein.; hypothetical protein	2970123..2970554	Mycobacterium tuberculosis H37Rv	887799
NP_217162.1	CDS	Rv2646	NC_000962.2	2970551	2971549	D	Rv2646, (MTCY441.16), len: 332 aa. Probable integrase, similar to others e.g. P06723|VINT_BP186|INT INTEGRASE from Bacteriophage 186 (336 aa)s FASTA scores: opt: 198, E(): 6.3e-05, (30.45% identity in 138 aa overlap). COULD BE BELONG TO THE 'PHAGE' INTEGRASE FAMILY.; integrase	2970551..2971549	Mycobacterium tuberculosis H37Rv	887706
NP_217163.1	CDS	Rv2647	NC_000962.2	2971659	2972027	D	Rv2647, (MTCY441.17), len: 122 aa (questionable ORF). Hypothetical protein, probably corresponds to conserved DNA sequence also found in MTCY336.29c and Rv1574|MTCY336.30c|O06616 HYPOTHETICAL 11.4 KDA PROTEIN from Mycobacterium tuberculosis (103 aa), FASTA scores: opt: 170, E(): 0.0002, (69.05% identity in 42 aa overlap). Shows weak similarity with Q9EUM1|RESB RESOLVASE PROTEIN HOMOLOG from Corynebacterium glutamicum (Brevibacterium flavum) (343 aa), FASTA scores: opt: 112, E(): 2.9, (31.05% identity in 87 aa overlap).; hypothetical protein	2971659..2972027	Mycobacterium tuberculosis H37Rv	885870
NP_217164.1	CDS	Rv2648	NC_000962.2	2972160	2972486	D	Rv2648, (MTCY441.17A), len: 108 aa. Probable transposase for IS6110.; transposase IS6110	2972160..2972486	Mycobacterium tuberculosis H37Rv	887828
NP_217165.1	CDS	Rv2649	NC_000962.2	<2972435	2973421	D	Rv2649, (MTCY441.18), len: 328 aa. Probable transposase for IS6110.; transposase IS6110	<2972435..2973421	Mycobacterium tuberculosis H37Rv	888553
NP_217166.1	CDS	Rv2650c	NC_000962.2	2973795	2975234	R	Rv2650c, (MTCY441.19), len: 479 aa. Possible phiRv2 prophage protein (capsid subunit) (see citation below), highly similar to O06614|Rv1576c|MTCY336.28 PROBABLE phiRv1 PHAGE PROTEIN from Mycobacterium tuberculosis (473 aa), FASTA scores: opt: 2782, E(): 2.8e-159, (89.1% identity in 468 aa overlap).; phiRv2 prophage protein	complement(2973795..2975234)	Mycobacterium tuberculosis H37Rv	887478
NP_217167.1	CDS	Rv2651c	NC_000962.2	2975242	2975775	R	Rv2651c, (MTCY441.20c), len: 177 aa. Possible protease protein (EC 3.4.-.-), phiRv2 phage protein (prohead protease) (see citation below), showing some similarity with several proteases e.g. Q9A4P4|CC2786 PUTATIVE PROTEASE from Caulobacter crescentus (138 aa), FASTA scores: opt: 206, E(): 2e-06, (36.35% identity in 132 aa overlap); Q9RNH0 PUTATIVE PROHEAD PROTEASE from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (184 aa), FASTA scores: opt: 196, E(): 1.1e-05, (35.05% identity in 137 aa overlap); BAB35014|ECS1591 PUTATIVE PROHEAD PROTEASE from Escherichia coli strain O157:H7 (185 aa), FASTA scores: opt: 187, E(): 4.1e-05, (32.9% identity in 158 aa overlap); etc. And highly similar to O06613|Rv1577c|MTCY336.27 Probable phiRV1 phage protein from Mycobacterium tuberculosis (170 aa), FASTA scores: opt: 987, E(): 2.3e-56, (89.35% identity in 169 aa overlap).; phiRv2 prophage protease	complement(2975242..2975775)	Mycobacterium tuberculosis H37Rv	887837
NP_217168.1	CDS	Rv2652c	NC_000962.2	2975928	2976554	R	Rv2652c, (MTCY441.21c), len: 208 aa. Probable phiRv2 phage protein (terminase) (see citation below), showing some similarity with AAK79859|Q97HW1|CAC1896 PHAGE TERMINASE-LIKE PROTEIN (SMALL SUBUNIT) from Clostridium acetobutylicum (151 aa), FASTA scores: opt: 155, E(): 0.012, (24.7% identity in 158 aa overlap); and Q9B019 HYPOTHETICAL 17.8 KDA PROTEIN from Bacteriophage GMSE-1 (159 aa), FASTA scores: opt: 141, E(): 0.087, (27.65% identity in 159 aa overlap). Also highly similar to O06612|Rv1578c|MTCY336.26 Probable phiRV1 phage protein from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 448, E(): 1.2e-20, (48.1% identity in 156 aa overlap). Equivalent to AAK47043 from Mycobacterium tuberculosis strain CDC1551 but longer 45 aa.; phiRv2 prophage protein	complement(2975928..2976554)	Mycobacterium tuberculosis H37Rv	888577
NP_217169.1	CDS	Rv2653c	NC_000962.2	2976586	2976909	R	Rv2653c, (MTCY441.22c), len: 107 aa. Hypothetical unknown protein, possibly phiRv2 phage protein (see citation below).; phiRv2 prophage protein	complement(2976586..2976909)	Mycobacterium tuberculosis H37Rv	887367
NP_217170.1	CDS	Rv2654c	NC_000962.2	2976989	2977234	R	Rv2654c, (MTCY441.23c), len: 81 aa. Hypothetical ala-rich protein, possibly phiRv2 phage protein (see citation below), similar to C-terminus of Q9HNI3|VNG2091H HYPOTHETICAL PROTEIN from Halobacterium sp. strain NRC-1 (212 aa), FASTA scores: opt: 122, E(): 0.46, (43.05% identity in 79 aa overlap).; phiRv2 prophage protein	complement(2976989..2977234)	Mycobacterium tuberculosis H37Rv	888154
NP_217171.1	CDS	Rv2655c	NC_000962.2	2977231	2978658	R	Rv2655c, (MTCY441.24c), len: 475 aa. Hypothetical protein, possibly phiRv2 phage protein (putative primase-like protein) (see citation below). C-terminus similar to P22875|YXIS_SACER HYPOTHETICAL 28.9 KDA PROTEIN (PROBABLY DOES NOT PLAY A DIRECT ROLE IN PLASMID INTEGRATION OR EXCISION) from Saccharopolyspora erythraea (Streptomyces erythraeus) plasmid pSE211 (263 aa), FASTA scores: opt: 389, E(): 2.7e-15, (33.45% identity in 269 aa overlap). Weak similarity in N-terminus to O06608|MTCY336.22|Rv1582c Probable phiRV1 phage protein from Mycobacterium tuberculosis (471 aa), FASTA scores: opt: 133, E(): 2.5, (36.0% identity in 75 aa overlap).; phiRv2 prophage protein	complement(2977231..2978658)	Mycobacterium tuberculosis H37Rv	887388
NP_217172.1	CDS	Rv2656c	NC_000962.2	2978660	2979052	R	Rv2656c, (MTCY441.25c), len: 130 aa. Probable phiRv2 phage protein (see Hatfull 2000), highly similar to O06607|YF83_MYCTU|Rv1583c|MT3573.2|MTCY336.21 Probable phiRV1 phage protein from Mycobacterium tuberculosis (132 aa), FASTA scores: opt: 734, E(): 2.5e-39, (81.5% identity in 131 aa overlap); and some similarity with Q982T4|MLL8506 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (204 aa), FASTA scores: opt: 104, E(): 9.7, (31.85% identity in 113 aa overlap).; phiRv2 prophage protein	complement(2978660..2979052)	Mycobacterium tuberculosis H37Rv	888179
NP_217173.1	CDS	Rv2657c	NC_000962.2	2979049	2979309	R	Rv2657c, (MTCY441.26c), len: 86 aa. Probable phiRv2 phage protein (excisionase) (see citation below), similar to O22001|VG36_BPMD2|36|G2 GENE 36 PROTEIN (GP36) from Mycobacteriophage D29 (56 aa), FASTA scores: opt: 171, E(): 9.6e-06, (48.0% identity in 50 aa overlap); and Q05246|VG36_BPML5|36 GENE 36 PROTEIN (GP36) from Mycobacteriophage L5 (56 aa), FASTA scores: opt: 169, E(): 1.3e-05, (50% identity in 50 aa overlap). Similarity suggests alternative start at 21737. Contains possible helix-turn-helix motif from aa 33 to 54 (Score 1655, +4.82 SD).; phiRv2 prophage protein	complement(2979049..2979309)	Mycobacterium tuberculosis H37Rv	887399
NP_217174.1	CDS	Rv2658c	NC_000962.2	2979326	2979688	R	Rv2658c, (MTCY441.27c), len: 120 aa. Hypothetical unknown protein, probably phage protein.; prophage protein	complement(2979326..2979688)	Mycobacterium tuberculosis H37Rv	888562
NP_217175.1	CDS	Rv2659c	NC_000962.2	2979691	2980818	R	Rv2659c, (MTCY441.28c), len: 375 aa. Probable integrase, phiRv2 phage protein: putative member of the phage integrase family of tyrosine recombinases (see Hatfull 2000), highly similar to others e.g. P22884|VINT_BPML5|33|INT from Mycobacteriophage L5 (371 aa), FASTA scores: opt: 836, E(): 1.2e-44, (39.0% identity in 372 aa overlap); Q38361|VINT_BPMD2|33|INT from Mycobacteriophage D29 (333 aa), FASTA scores: opt: 786, E(): 1.4e-41, (40.55% identity in 338 aa overlap); etc. SEEMS BELONGS TO THE 'PHAGE' INTEGRASE FAMILY.; phiRv2 prophage integrase	complement(2979691..2980818)	Mycobacterium tuberculosis H37Rv	885098
NP_217176.1	CDS	Rv2660c	NC_000962.2	2980963	2981190	R	Rv2660c, (MTCY441.29c), len: 75 aa (questionable orf). Hypothetical unknown protein.; hypothetical protein	complement(2980963..2981190)	Mycobacterium tuberculosis H37Rv	887222
NP_217177.1	CDS	Rv2661c	NC_000962.2	2981187	2981576	R	Rv2661c, (MTCY441.30c), len: 129 aa. Hypothetical unknown protein.; hypothetical protein	complement(2981187..2981576)	Mycobacterium tuberculosis H37Rv	888545
NP_217178.1	CDS	Rv2662	NC_000962.2	2981482	2981754	D	Rv2662, (MTCY441.31), len: 90 aa. Hypothetical unknown protein.; hypothetical protein	2981482..2981754	Mycobacterium tuberculosis H37Rv	888589
NP_217179.1	CDS	Rv2663	NC_000962.2	2981853	2982086	D	Rv2663, (MTCY441.32), len: 77 aa. Hypothetical unknown protein.; hypothetical protein	2981853..2982086	Mycobacterium tuberculosis H37Rv	888561
NP_217180.1	CDS	Rv2664	NC_000962.2	2982097	2982351	D	Rv2664, (MTCY441.33), len: 84 aa. Hypothetical protein. Some weak similarity to nearby P71964|Rv2667|clpX'|MT2741|MTCY441.36 POSSIBLE ATP-DEPENDENT PROTEASE ATP-BINDING SUBUNIT from Mycobacterium tuberculosis (252 aa), FASTA scores: opt: 134, E(): 0.027, (31.15% identity in 77 aa overlap).; hypothetical protein	2982097..2982351	Mycobacterium tuberculosis H37Rv	888501
NP_217181.1	CDS	Rv2665	NC_000962.2	2982699	2982980	D	Rv2665, (MTCY441.34), len: 93 aa. Hypothetical arg-rich protein, showing some similarity to N-terminus of P71640|Rv2811|MTCY16B7.32c HYPOTHETICAL 21.1 KDA PROTEIN from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 157, E(): 0.0011, (37.5% identity in 72 aa overlap); and also to part of O35132|CP2B_RAT|CYP27B1|CYP27B 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR from Rattus norvegicus (Rat) (501 aa), FASTA scores: opt: 106, E(): 5.4, (34.5% identity in 87 aa overlap).; hypothetical protein	2982699..2982980	Mycobacterium tuberculosis H37Rv	887748
NP_217182.1	CDS	Rv2666	NC_000962.2	2983071	2983874	D	Rv2666, (MTCY441.35), len: 267 aa. Probable transposase (fragment), identical in region of overlap to P35882|TRA1_MYCBO|TRA1_MYCTU TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1081 from Mycobacterium tuberculosis or bovis (415 aa). Last 4 codons not part of gene. Contains PS01007 Transposases, Mutator family, signature.; truncated IS1081 transposase	2983071..2983874	Mycobacterium tuberculosis H37Rv	888904
YP_177897.1	CDS	clpC2	NC_000962.2	2983896	2984654	D	Rv2667, (MTCY441.36), len: 252 aa. Possible clpC2, ATP-dependent protease atp-binding subunit (EC 3.4.-.-), highly similar to Q9X8L2|SCE9.40 HYPOTHETICAL 27.3 KDA PROTEIN from Streptomyces coelicolor (258 aa), FASTA scores: opt: 877, E(): 2.2e-46, (57.25% identity in 255 aa overlap). The second half of the protein is highly similar to N-terminal of several CLP-FAMILY proteins e.g. P24428|CLPC_MYCLE|ML0235 PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT from Mycobacterium leprae (848 aa), FASTA scores: opt: 307, E(): 3.2e-11, (38.6% identity in 158 aa overlap); O06286|CLPC_MYCTU|Rv3596c|MT3703|MTCY07H7B.26 PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT from Mycobacterium tuberculosis (848 aa), FASTA scores: opt: 307, E(): 3.2e-11, (38.6% identity in 158 aa overlap); Q9S6T8|SCE94.24c PUTATIVE CLP-FAMILY ATP-BINDING PROTEASE from Streptomyces coelicolor (841 aa), FASTA scores: opt: 303, E(): 5.6e-11, (38.8% identity in 152 aa overlap); etc. Some weak similarity to nearby P71961|MTCY441.33|Rv2664 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (83 aa). Contain Pfam match to entry PF02861 Clp amino terminal domain. BELONGS TO THE CLPA/CLPB FAMILY. CLPC SUBFAMILY. Note that previously known as clpX'; clpX'; ATP-dependent protease ATP-binding subunit ClpC2	2983896..2984654	Mycobacterium tuberculosis H37Rv	887415
NP_217184.1	CDS	Rv2668	NC_000962.2	2984733	2985254	D	Rv2668, (MTCY441.37), len: 173 aa. Hypothetical ala-, val-rich protein, possibly exported. Equivalent to AAK47057 from Mycobacterium tuberculosis strain CDC1551 (208 aa) but N-terminal part shorter 35 aa and with few differences. Has potential signal peptide sequence.; hypothetical protein	2984733..2985254	Mycobacterium tuberculosis H37Rv	887993
NP_217185.1	CDS	Rv2669	NC_000962.2	2985283	2985753	D	Rv2669, (MTCY441.38), len: 156 aa. Conserved hypothetical protein, showing some similarity to various proteins e.g. Q9A6M0|CC2073 ACETYLTRANSFERASE (GNAT FAMILY) from Caulobacter crescentus (178 aa), FASTA scores: opt: 242, E(): 1.2e-09, (30.9% identity in 165 aa overlap); Q99RQ8|SA2159 hypothetical protein similar to transcription repressor of sporulation, septation and degradation paiA from Staphylococcus aureus subsp. aureus N315 (171 aa), FASTA scores: opt: 214, E(): 9.8e-08, (27.5% identity in 160 aa overlap); BAB58531|SAV2369 HYPOTHETICAL 20.1 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (171 aa), FASTA scores: opt: 214, E(): 9.8e-08, (27.5% identity in 160 aa overlap); P21340|PAIA_BACSU|O32112 PROTEASE SYNTHASE AND SPORULATION from Bacillus subtilis (171 aa), FASTA scores: opt: 209, E(): 2.1e-07, (22.85% identity in 162 aa overlap); etc.; hypothetical protein	2985283..2985753	Mycobacterium tuberculosis H37Rv	887699
NP_217186.1	CDS	Rv2670c	NC_000962.2	2985731	2986840	R	Rv2670c, (MTCY441.39c), len: 369 aa. Conserved hypothetical protein, equivalent, but longer 164 aa, to O05683|MLC1351.22c HYPOTHETICAL 17.3 KDA PROTEIN from Mycobacterium leprae (160 aa), FASTA scores: opt: 847, E(): 1.2e-45, (82.4% identity in 159 aa overlap). And highly similar to Q9X824|SC9B1.04c PUTATIVE ATP/GTP-BINDING INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (350 aa), FASTA scores: opt: 1169, E(): 2e-65, (56.85% identity in 343 aa overlap); and Q9RWB0|DR0759 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (351 aa), FASTA scores: opt: 859, E(): 4e-46, (45.9% identity in 331 aa overlap). Also some similarity with other proteins e.g. P46442|YHCM_ECOLI|AAG58360|BAB37528 HYPOTHETICAL PROTEIN from Escherichia coli strains K12 and O157:H7 (375 aa), FASTA scores: opt: 237, E(): 2.1e-07, (28.0% identity in 325 aa overlap); Q9JRK2|NMA1520|NMB1306 PUTATIVE NUCLEOTIDE-BINDING PROTEIN from Neisseria meningitidis (serogroup A and B) (383 aa), FASTA scores: opt: 221, E(): 2.1e-06, (27.8% identity in 356 aa overlap); Q9HVX7|PA4438 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (364 aa), FASTA scores: opt: 211, E(): 8.5e-06, (28.9% identity in 353 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	complement(2985731..2986840)	Mycobacterium tuberculosis H37Rv	887407
NP_217187.1	CDS	ribD	NC_000962.2	2986839	2987615	D	Rv2671, (MTCY441.40), len: 258 aa. Possible ribD (alternate gene name: ribG), bifunctional riboflavin biosynthesis protein incuding diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193), highly similar to O05684|MLC1351.23|ML1340 POSSIBLE REDUCTASE from Mycobacterium leprae (268 aa), FASTA scores: opt: 1211, E(): 3e-68, (72.9% identity in 251 aa overlap). Also weakly similar to others e.g. Q9HWX2|RIBD|PA4056 RIBOFLAVIN-SPECIFIC DEAMINASE/REDUCTASE from Pseudomonas aeruginosa (373 aa), FASTA scores: opt: 211, E(): 6.3e-06, (30.1% identity in 216 aa overlap); Q9HQA1|RIBG|VNG1256G RIBOFLAVIN-SPECIFIC DEAMINASE from Halobacterium sp. strain NRC-1 (220 aa), FASTA scores: opt: 202, E(): 1.5e-05, (27.0% identity in 174 aa overlap); O28272|RIB7_ARCFU|AF2007 PUTATIVE 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE) (EC 1.1.1.193) from Archaeoglobus fulgidus (219 aa), FASTA scores: opt: 209, E(): 5.4e-06, (24.15% identity in 211 aa overlap); P25539|RIBD_ECOLI|RIBG|B0414 from Escherichia coli strain K12 (367 aa), FASTA scores: opt: 185, E(): 0.00026, (26.7% identity in 221 aa overlap); etc. But also similar to several hydrolases e.g. Q9X825|SC9B1.05 PUTATIVE HYDROLASE from Streptomyces coelicolor (265 aa), FASTA scores: opt: 536, E(): 2.9e-26, (44.25% identity in 235 aa overlap); Q9RKM1|SCD17.10 PUTATIVE BIFUNCTIONAL ENZYME DEAMINASE/REDUCTASE from Streptomyces coelicolor (376 aa), FASTA scores: opt: 228, E(): 5.6e-07, (33.5% identity in 188 aa overlap); etc. Equivalent to AAK47060 from Mycobacterium tuberculosis strain CDC1551 (239 aa) but longer 19 aa. SUPPOSED BELONG TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY IN THE N-TERMINAL SECTION; and TO THE HTP REDUCTASE FAMILY IN THE C-TERMINAL SECTION.; ribG; hypothetical protein	2986839..2987615	Mycobacterium tuberculosis H37Rv	887389
NP_217188.1	CDS	Rv2672	NC_000962.2	2987682	2989268	D	Rv2672, (MTCY441.41), len: 528 aa. Possible secreted protease (EC 3.4.-.-), equivalent to O05685|MLC1351.24|ML1339 PUTATIVE SECRETED PROTEASE from Mycobacterium leprae (525 aa), FASTA scores: opt: 2722, E(): 9.4e-140, (74.45% identity in 528 aa overlap). Also similar to several exported proteinases from Streptomyces and Mycobacteria e.g. Q54399|SLPE PROTEINASE from Streptomyces lividans (513 aa), FASTA scores: opt: 429, E(): 6.8e-16, (26.2% identity in 538 aa overlap); Q9FCK9|2SC3B6.03c PEPTIDASE from Streptomyces coelicolor (513 aa), FASTA scores: opt: 421, E(): 1.8e-15, (26.45% identity in 541 aa overlap); Q10508|YM23_MYCTU from Mycobacterium tuberculosis (520 aa), FASTA scores: opt: 349, E(): 1.4e-11, (26.6% identity in 523 aa overlap); etc. Equivalent to AAK47061 from Mycobacterium tuberculosis strain CDC1551 (518 aa) but longer 10 aa.; secreted protease	2987682..2989268	Mycobacterium tuberculosis H37Rv	887398
NP_217189.1	CDS	Rv2673	NC_000962.2	2989291	2990592	D	Rv2673, (MTCY441.42), len: 433 aa. Possible conserved integral membrane protein, equivalent to MLC1351.25|ML1338 POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (440 aa), FASTA scores: opt: 2410, E(): 5.3e-143, (82.05% identity in 434 aa overlap); and showing some similarity with Q9CBX0|ML1504 PROBABLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (430 aa), FASTA scores: opt: 159, E(): 0.014, (24.4% identity in 340 aa overlap). Also similar to Q53873|SC6G4.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (411 aa), FASTA scores: opt: 383, E(): 1.4e-16, (29.6% identity in 422 aa overlap); and with weak similarity with P71061|YVFB HYPOTHETICAL PROTEIN from Bacillus subtilis (396 aa), FASTA scores: opt: 136, E(): 0.36, (24.35% identity in 279 aa overlap); and BAB60134|TVG1014811 HYPOTHETICAL PROTEIN from Thermoplasma volcanium (695 aa), FASTA scores: opt: 133, E(): 0.85, (26.45% identity in 280 aa overlap). Shows also some similarity with O06557|Rv1159|MTCI65.26 HYPOTHETICAL 47.1 KDA PROTEIN from Mycobacterium tuberculosis (431 aa), FASTA scores: opt: 149, E(): 0.059, (22.45% identity in 410 aa overlap); and O53515|Rv2181|MTV021.14 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis (427 aa), FASTA scores: opt: 129, E(): 1, (24.8% identity in 367 aa overlap).; integral membrane protein	2989291..2990592	Mycobacterium tuberculosis H37Rv	887396
NP_217190.1	CDS	Rv2674	NC_000962.2	2990706	2991116	D	Rv2674, (MTCY441.43), len: 136 aa. Conserved hypothetical protein, highly similar to various proteins e.g. Q9X828|SC9B1.08 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (135 aa), FASTA scores: opt: 653, E(): 1.8e-37, (71.1% identity in 128 aa overlap); O26807|MTH711 TRANSCRIPTIONAL REGULATOR from Methanothermobacter thermautotrophicus (151 aa), FASTA scores: opt: 533, E(): 2.7e-29, (58.15% identity in 129 aa overlap); Q9C5C8|AT4G21860 HYPOTHETICAL 22.0 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (202 aa), FASTA scores: opt: 490, E(): 2.8e-26, (54.05% identity in 124 aa overlap); P39903|YEAA_ECOLI|B1778|Z2817|ECS2487 HYPOTHETICAL PROTEIN from Escherichia coli strains K12 and O157:H7 (137 aa), FASTA scores: opt: 426, E(): 4.4e-22, (46.8% identity in 126 aa overlap).; hypothetical protein	2990706..2991116	Mycobacterium tuberculosis H37Rv	886019
NP_217191.1	CDS	Rv2675c	NC_000962.2	2991184	2991936	R	Rv2675c, (MTCY441.44c), len: 250 aa. Conserved hypothetical protein. C-terminus highly similar to Q50010|U1764Z from Mycobacterium leprae (69 aa), FASTA scores: opt: 284, E(): 4.6e-11, (68.25% identity in 63 aa overlap). Shows some similarity with Q9P3V6|SPAC1348.04 (alias Q9P3E7|Q9P7U5) HYPOTHETICAL 16.6 KDA PROTEIN from Schizosaccharomyces pombe (Fission yeast) (145 aa), FASTA scores: opt: 203, E(): 9.5e-06, (33.05% identity in 118 aa overlap); Q9ZSZ7|BMCT METHYL CHLORIDE TRANSFERASE from Batis maritima (230 aa), FASTA scores: opt: 197, E(): 3.3e-05, (28.85% identity in 156 aa overlap); P72459|STSG METHYLTRANSFERASE from Streptomyces griseus (253 aa), FASTA scores: opt: 194, E(): 5.5e-05, (24.45% identity in 229 aa overlap); etc. Also similar to various proteins from Mycobacterium tuberculosis e.g. P71805|Rv1377c|MTCY02B12.11c HYPOTHETICAL 22.8 KDA PROTEIN (212 aa), FASTA scores: opt: 431, E(): 8.3e-20, (39.1% identity in 197 aa overlap); O06426|Rv0560c|MTCY25D10.39c HYPOTHETICAL 25.9 KDA PROTEIN (241 aa), FASTA scores: opt: 379, E(): 1.6e-16, (35.95% identity in 178 aa overlap); O69667|Rv3699|MTV025.047 PUTATIVE METHYLTRANSFERASE (233 aa), FASTA scores: opt: 297, E(): 2e-11, (30.55% identity in 193 aa overlap); etc.; hypothetical protein	complement(2991184..2991936)	Mycobacterium tuberculosis H37Rv	887760
NP_217192.1	CDS	Rv2676c	NC_000962.2	2991933	2992628	R	Rv2676c, (MTCY441.45c), len: 231 aa. Conserved hypothetical protein, equivalent to Q9CCB2|ML1045 (alias Q50009|U1764Y but longer 66 aa) HYPOTHETICAL PROTEIN from Mycobacterium leprae (231 aa), FASTA scores: opt: 1401, E(): 8.7e-88, (87.45% identity in 231 aa overlap). Also highly similar to O69830|SC1B5.02 HYPOTHETICAL 28.1 KDA PROTEIN from Streptomyces coelicolor (243 aa), FASTA scores: opt: 915, E(): 7.7e-55, (61.25% identity in 222 aa overlap); and similar to others e.g. Q9RUB0|DR1481 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (289 aa), FASTA scores: opt: 327, E(): 6.1e-15, (31.8% identity in 176 aa overlap); Q97WP2|SSO2169 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (223 aa), FASTA scores: opt: 285, E(): 3.4e-12, (31.3% identity in 163 aa overlap); BAB59947|TVG0805714 HYPOTHETICAL PROTEIN from Thermoplasma volcanium (223 aa), FASTA scores: opt: 206, E(): 7.7e-07, (25.0% identity in 176 aa overlap); etc.; hypothetical protein	complement(2991933..2992628)	Mycobacterium tuberculosis H37Rv	887718
YP_177675.1	CDS	hemY	NC_000962.2	2992634	2993992	R	catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase	complement(2992634..2993992)	Mycobacterium tuberculosis H37Rv	887711
NP_217194.1	CDS	hemE	NC_000962.2	2993989	2995062	R	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase	complement(2993989..2995062)	Mycobacterium tuberculosis H37Rv	888934
NP_217195.1	CDS	echA15	NC_000962.2	2995115	2995945	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	2995115..2995945	Mycobacterium tuberculosis H37Rv	887693
NP_217196.1	CDS	Rv2680	NC_000962.2	2996105	2996737	D	Rv2680, (MTV010.04), len: 210 aa. Conserved hypothetical protein, equivalent to Q50005|ML1041|U1764V HYPOTHETICAL PROTEIN from Mycobacterium leprae (196 aa), FASTA scores: opt: 1136, E(): 9.7e-66, (83.95% identity in 193 aa overlap). Also similar to O69860|SC1C3.18c HYPOTHETICAL 24.7 KDA PROTEIN from Streptomyces coelicolor (238 aa), FASTA scores: opt: 516, E(): 5.7e-26, (45.5% identity in 189 aa overlap); and similar in part to Q9I6V4|PA0178 PROBABLE TWO-COMPONENT SENSOR from Pseudomonas aeruginosa (639 aa), FASTA scores: opt: 120, E(): 3.1, (33.05% identity in 115 aa overlap); and a few other proteins. Equivalent to AAK47069 from Mycobacterium tuberculosis strain CDC1551 (178 aa) but longer 32 aa; and N-terminus highly similar to N-terminus of AAK48352|MT3984 HYPOTHETICAL 4.2 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (38 aa), FASTA scores: opt: 102, E(): 3.6, (62.05% identity in 29 aa overlap). TBparse score is 0.886.; hypothetical protein	2996105..2996737	Mycobacterium tuberculosis H37Rv	887734
NP_217197.1	CDS	Rv2681	NC_000962.2	2996739	2998055	D	Rv2681, (MTCY05A6.02), len: 438 aa. Conserved hypothetical ala-rich protein, equivalent to Q50004|ML1040|U1764U HYPOTHETICAL PROTEIN from Mycobacterium leprae (429 aa), FASTA scores: opt: 2146, E(): 1.1e-119, (77.4% identity in 416 aa overlap). Also highly similar to O69858|SC1C3.16c HYPOTHETICAL 42.5 KDA PROTEIN from Streptomyces coelicolor (394 aa), FASTA scores: opt: 1336, E(): 9e-72, (51.6% identity in 405 aa overlap); and with some similarity to RIBONUCLEASES D e.g. Q983F2|MLL8354 from Rhizobium loti (Mesorhizobium loti) (383 aa), FASTA scores: opt: 379, E(): 3.9e-15, (31.6% identity in 323 aa overlap); Q9A7L8|CC1704 from Caulobacter crescentus (389 aa), FASTA scores: opt: 370, E(): 1.3e-14, (31.45% identity in 318 aa overlap); CAC45770 from Rhizobium meliloti (Sinorhizobium meliloti) (383 aa), FASTA scores: opt: 331, E(): 2.7e-12, (27.75% identity in 357 aa overlap); etc. TBparse score is 0.915.; hypothetical protein	2996739..2998055	Mycobacterium tuberculosis H37Rv	887708
YP_177898.1	CDS	dxs1	NC_000962.2	2998052	2999968	R	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase	complement(2998052..2999968)	Mycobacterium tuberculosis H37Rv	887461
NP_217199.1	CDS	Rv2683	NC_000962.2	3000112	3000609	D	Rv2683, (MTCY05A6.04), len: 165 aa. Conserved hypothetical protein, equivalent, but shorter 19 aa, to Q49999|ML1037|U1764Q HYPOTHETICAL PROTEIN from Mycobacterium leprae (184 aa), FASTA scores: opt: 750, E(): 1.2e-41, (73.8% identity in 164 aa overlap). Shows some similarity with other HYPOTHETICAL PROTEINS e.g. Q988S9|MLL6611 from Rhizobium loti (Mesorhizobium loti) (232 aa), FASTA scores: opt: 128, E(): 0.25, (25.5% identity in 149 aa overlap); Q9YFL5|APE0233 from Aeropyrum pernix (340 aa), FASTA scores: opt: 123, E(): 0.73, (29.1% identity in 141 aa overlap); BAB60477|TVG1377730 from Thermoplasma volcanium (174 aa), FASTA scores: opt: 118, E(): 0.86, (28.8% identity in 59 aa overlap); etc. TBparse score is 0.926.; hypothetical protein	3000112..3000609	Mycobacterium tuberculosis H37Rv	887207
NP_217200.1	CDS	arsA	NC_000962.2	3000614	3001903	D	Rv2684, (MTCY05A6.05), len: 429 aa. Probable arsA, arsenic-transport integral membrane protein, equivalent to P46838|AG45_MYCLE|ML1036 46 KDA PROBABLE INTEGRAL MEMBRANE PROTEIN (antigen 45, a transmembrane protein related to arsenical pumps) from Mycobacterium leprae (429 aa), FASTA scores: opt: 2067, E(): 9.9e-118, (74.05% identity in 428 aa overlap); and upstream orf O07187|YQ85_MYCTU|ARSB|Rv2685|MT2759|MTCY05A6.06 PROBABLE INTEGRAL MEMBRANE 45.2 KDA PROTEIN ARSB from Mycobacterium tuberculosis (428 aa), FASTA scores: opt: 2148, E(): 1.3e-122, (76.58% identity in 427 aa overlap). Also highly similar to other proteins e.g. Q9UY19|PAB1107 TRANSPORT PROTEIN from Pyrococcus abyssi (425 aa), FASTA scores: opt: 1109, E(): 8.3e-60, (41.45% identity in 427 aa overlap); O59575|PH1912 HYPOTHETICAL 46.0 KDA PROTEIN from Pyrococcus horikoshii (424 aa), FASTA scores: opt: 1101, E(): 2.5e-59, (41.95% identity in 429 aa overlap); Q9KDI2|BH1231 HYPOTHETICAL 46.0 KDA PROTEIN from Bacillus halodurans (428 aa), FASTA scores: opt: 1018, E(): 2.7e-54, (38.9% identity in 427 aa overlap); etc. BELONGS TO THE NADC/P/PHO87 FAMILY OF TRANSPORTERS, P SUBFAMILY (ARS FAMILY). TBparse score is 0.891.; arsenic-transport integral membrane protein ArsA	3000614..3001903	Mycobacterium tuberculosis H37Rv	888366
YP_177899.1	CDS	arsB1	NC_000962.2	3001983	3003269	D	Rv2685, (MTCY05A6.06), len: 428 aa. Probable arsB1, arsenic-transport integral membrane protein, equivalent to P46838|AG45_MYCLE|ML1036 46 KDA PROBABLE INTEGRAL MEMBRANE PROTEIN (antigen 45, a transmembrane protein related to arsenical pumps) from Mycobacterium leprae (429 aa), FASTA scores: opt: 2048, E(): 7.3e-120, (74.25% identity in 427 aa overlap); and downstream ORF O07186|YQ84_MYCTU|ARSA|Rv2684|MT2758|MTCY05A6.05 PROBABLE INTEGRAL MEMBRANE PROTEIN ARSA from Mycobacterium tuberculosis (429 aa), FASTA scores: opt: 2154, E(): 1.9e-126, (76.8% identity in 427 aa overlap). Also highly similar to other proteins e.g. O59575|PH1912 HYPOTHETICAL 46.0 KDA PROTEIN from Pyrococcus horikoshii (424 aa), FASTA scores: opt: 1075, E(): 1.9e-59, (43.55% identity in 427 aa overlap); Q9UY19|PAB1107 TRANSPORT PROTEIN from Pyrococcus abyssi (425 aa), FASTA scores: opt: 1062, E(): 1.3e-58, (41.8% identity in 428 aa overlap); Q9KDI2|BH1231 HYPOTHETICAL 46.0 KDA PROTEIN from Bacillus halodurans (428 aa), FASTA scores: opt: 993, E(): 2.4e-54, (39.55% identity in 430 aa overlap); etc. BELONGS TO THE NADC/P/PHO87 FAMILY OF TRANSPORTERS, P SUBFAMILY. TBparse score is 0.881. Note that previously known as arsB.; arsB; arsenic-transport integral membrane protein ArsB1	3001983..3003269	Mycobacterium tuberculosis H37Rv	888150
NP_217202.1	CDS	Rv2686c	NC_000962.2	3003280	3004038	R	Rv2686c, (MTCY05A6.07c), len: 252 aa. Probable antibiotic-transport integral membrane leu-, ala-, val-rich protein ABC transporter (see citation below). The region from aa 115 to 160 is highly similar to N-terminus of Q49998|U1764P HYPOTHETICAL PROTEIN from Mycobacterium leprae (53 aa), FASTA scores: opt: 151, E(): 0.011, (58.15% identity in 43 aa overlap). Shows some similarity with membrane proteins e.g. AAK75541|SP1447 MEMBRANE PROTEIN from Streptococcus pneumoniae (298 aa), FASTA scores: opt: 139, E(): 0.21, (29.65% identity in 135 aa overlap); Q9K4C9|2SC6G5.26c PUTATIVE ABC TRANSPORTER INTEGRAL MEMBRANE SUBUNIT from Streptomyces coelicolor (249 aa), FASTA scores: opt: 138, E(): 0.21, (26.9% identity in 253 aa overlap); Q53627|MTRB MEMBRANE PROTEIN INVOLVED IN MITHRAMYCIN RESISTANCE from Streptomyces argillaceus (233 aa), FASTA scores: opt: 136, E(): 0.27, (26.7% identity in 191 aa overlap); etc. TBparse score is 0.899.; antibiotic ABC transporter transmembrane protein	complement(3003280..3004038)	Mycobacterium tuberculosis H37Rv	888360
NP_217203.1	CDS	Rv2687c	NC_000962.2	3004035	3004748	R	Rv2687c, (MTCY05A6.08c), len: 237 aa. Probable antibiotic-transport integral membrane leu-, val-rich protein ABC transporter (see citation below), showing some similarity with two other hypothetical proteins, BAB59668|TVG0517148 from Thermoplasma volcanium (241 aa), FASTA scores: opt: 136, E(): 0.32, (23.1% identity in 208 aa overlap); and Q97U55|SSO3168 from Sulfolobus solfataricus (249 aa), FASTA scores: opt: 136, E(): 0.33, (25.15% identity in 195 aa overlap). Has some hydrophobic stretches and contains bacterial regulatory proteins, araC family signature (PS00041). TBparse score is 0.891.; antibiotic ABC transporter transmembrane protein	complement(3004035..3004748)	Mycobacterium tuberculosis H37Rv	888446
NP_217204.1	CDS	Rv2688c	NC_000962.2	3004745	3005650	R	Rv2688c, (MTCY05A6.09c), len: 301 aa. Probable antibiotic-transport ATP-binding protein ABC transporter (see citation below), highly similar to AAK47077|MT2762 ABC TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium tuberculosis strain CDC1551 (317 aa), FASTA scores: opt: 1714, E(): 5.1e-93, (95.6% identity in 274 aa overlap). Also highly similar to other ATP-BINDING PROTEINS ABC TRANSPORTER e.g. Q9K639|BH3893 from Bacillus halodurans (282 aa), FASTA scores: opt: 644, E(): 1.4e-30, (38.% identity in 285 aa overlap); O58550|PH0820 from Pyrococcus horikoshii (312 aa), FASTA scores: opt: 574, E(): 1.8e-26, (39.1% identity in 307 aa overlap); Q9WYM0|TM0389 from Thermotoga maritima (301 aa), FASTA scores: opt: 536, E(): 2.9e-24, (36.1% identity in 291 aa overlap); etc. Has ATP/GTP-binding site motif A (P-loop) at N-terminus (PS00017). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.872.; antibiotic ABC transporter ATP-binding protein	complement(3004745..3005650)	Mycobacterium tuberculosis H37Rv	888463
NP_217205.1	CDS	Rv2689c	NC_000962.2	3005845	3007062	R	Rv2689c, (MTCY05A6.10c), len: 405 aa (other less probable starts possible). Conserved hypothetical ala-, val-, gly-rich protein, similar to O54099|SC10A5.06 HYPOTHETICAL 49.5 KDA PROTEIN from Streptomyces coelicolor (458 aa), FASTA scores: opt: 455, E(): 2.7e-20, (38.35% identity in 417 aa overlap); and shows weak similarity in part with several methyltransferases (EC 2.1.1.-) e.g. Q9X0H9|TM1094 PUTATIVE RNA METHYLTRANSFERASE from Thermotoga maritima (439 aa), FASTA scores: opt: 306, E(): 3e-11, (25.9% identity in 436 aa overlap); AK79403|CAC1435 S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES from Clostridium acetobutylicum (456 aa), FASTA scores: opt: 294, E(): 1.6e-10, (23.4% identity in 449 aa overlap); Q9A8M7|CC1326 RNA METHYLTRANSFERASE from Caulobacter crescentus (415 aa), FASTA scores: opt: 247, E(): 1.1e-07, (28.4% identity in 433 aa overlap); etc. Equivalent to AAK47078 from Mycobacterium tuberculosis strain CDC1551 (434 aa) but shorter 29 aa. TBparse score is 0.921.; hypothetical protein	complement(3005845..3007062)	Mycobacterium tuberculosis H37Rv	887219
NP_217206.1	CDS	Rv2690c	NC_000962.2	3007236	3009209	R	Rv2690c, (MTCY05A6.11c), len: 657 aa. Probable conserved integral membrane ala-, val-, leu-rich protein, highly similar to others e.g. O54098|SC10A5.05 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (691 aa), FASTA scores: opt: 2007, E(): 1.6e-116, (62.35% identity in 669 aa overlap); O69917|SC3C8.04c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (644 aa), FASTA scores: opt: 923, E(): 1.7e-49, (35.3% identity in 669 aa overlap); AAK78253|CAC0272 AMINO ACID TRANSPORTER from Clostridium acetobutylicum (620 aa), FASTA scores: opt: 674, E(): 4.1e-34, (36.55% identity in 640 aa overlap); etc. TBparse score is 0.901.; hypothetical protein	complement(3007236..3009209)	Mycobacterium tuberculosis H37Rv	888011
YP_177900.1	CDS	ceoB	NC_000962.2	3009344	3010027	D	Rv2691, (MTCY05A6.12), len: 227 aa. ceoB (alternate gene name: trkA), TRK system potassium uptake protein (see citation below), highly similar to others e.g. Q53949|TRKA_STRCO|SC2E9.17c from Streptomyces coelicolor (223 aa), FASTA scores: opt: 781, E(): 5.8e-42, (53.2% identity in 220 aa overlap); O27333|TRKA_METTH|MTH1265 from Methanobacterium thermoautotrophicum (216 aa), FASTA scores: opt: 287, E(): 5.3e-11, (27.0% identity in 211 aa overlap); O54141|SC2E9.16c from Streptomyces coelicolor (226 aa), FASTA scores: opt: 269, E(): 7.3e-10, (29.9% identity in 214 aa overlap); etc. Also similar to upstream orf O07194|CEOC|TRKA_MYCTU|TRKA|TRKB|Rv2692|MT2766|MTCY05A6.1 3 TRK SYSTEM POTASSIUM UPTAKE PROTEIN from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 259, E(): 3e-09, (26.55% identity in 226 aa overlap). Contains a motif common to NAD+ binding pockets (see citation below). BELONGS TO THE TRKA FAMILY.; trkA; TRK system potassium uptake protein CEOB	3009344..3010027	Mycobacterium tuberculosis H37Rv	887250
YP_177901.1	CDS	ceoC	NC_000962.2	3010024	3010686	D	Rv2692, (MTCY05A6.13), len: 220 aa. ceoC (alternate gene names: trkA and trkB), TRK system potassium uptake protein (see citation below), highly similar to others e.g. O54141|SC2E9.16c from Streptomyces coelicolor (226 aa), FASTA scores: opt: 870, E(): 9.4e-48, (58.8% identity in 216 aa overlap); Q58505|TRKA_METJA|MJ1105 from Methanococcus jannaschii (218 aa), FASTA scores: opt: 361, E(): 9.7e-16, (29.8% identity in 218 aa overlap); O27333|TRKA_METTH|MTH1265 from Methanobacterium thermoautotrophicum (216 aa), FASTA scores: opt: 326, E(): 1.5e-13, (30.1% identity in 216 aa overlap); etc. Also similar to downstream orf O07193|CEOB|TRKA|Rv2691|MTCY05A6.12 TRK SYSTEM POTASSIUM UPTAKE PROTEIN from Mycobacterium tuberculosis (227 aa), FASTA scores: opt: 259, E(): 2.6e-09, (26.55% identity in 226 aa overlap). Contains a motif common to NAD+ binding pockets (see citation below). BELONGS TO THE TRKA FAMILY.; trkA; trkB; TRK system potassium uptake protein CEOC	3010024..3010686	Mycobacterium tuberculosis H37Rv	887493
NP_217209.1	CDS	Rv2693c	NC_000962.2	3010697	3011368	R	Rv2693c, (MTCY05A6.14c), len: 223 aa. Probable conserved integral membrane ala-, leu-rich protein, showing some similarity to O54140|SC2E9.15 HYPOTHETICAL 29.6 KDA PROTEIN from Streptomyces coelicolor (272 aa), FASTA scores: opt: 212, E(): 4.3e-06, (23.5% identity in 247 aa overlap). TBparse score is 0.902.; integral membrane alanine and leucine rich protein	complement(3010697..3011368)	Mycobacterium tuberculosis H37Rv	887917
NP_217210.1	CDS	Rv2694c	NC_000962.2	3011399	3011767	R	Rv2694c, (MTCY05A6.15c), len: 122 aa. Conserved hypothetical protein, highly similar in part to SC2E9.14 HYPOTHETICAL 16.9 KDA PROTEIN from Streptomyces coelicolor (154 aa), FASTA scores: opt: 299, E(): 1.9e-13, (41.05% identity in 117 aa overlap. Equivalent to AAK47083 from Mycobacterium tuberculosis strain CDC1551 (157 aa) but shorter 35 aa. TBparse score is 0.904.; hypothetical protein	complement(3011399..3011767)	Mycobacterium tuberculosis H37Rv	888911
NP_217211.1	CDS	Rv2695	NC_000962.2	3011916	3012623	D	Rv2695, (MTCY05A6.16), len: 235 aa. Conserved hypothetical ala-rich protein, equivalent to Q49994|ML1030|U1764L HYPOTHETICAL PROTEIN from Mycobacterium leprae (232 aa), FASTA scores: opt: 1166, E(): 6.3e-63, (76.95% identity in 230 aa overlap). Also shows some similarity with other hypothetical proteins e.g. Q986S2|MLR7232 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (277 aa), FASTA scores: opt: 150, E(): 0.059, (33.55% identity in 173 aa overlap); CAC47772|SMC03810 HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (269 aa), FASTA scores: opt: 143, E(): 0.15, (28.05% identity in 228 aa overlap); Q9A5N6|CC2411 3-OXOADIPATE ENOL-LACTONE HYDROLASE/4-CARBOXYMUCONOLACTONE DECARBOXYLASE from Caulobacter crescentus (393 aa), FASTA scores: opt: 138, E(): 0.41, (26.45% identity in 238 aa overlap); etc. TBparse score is 0.897.; hypothetical protein	3011916..3012623	Mycobacterium tuberculosis H37Rv	888223
NP_217212.1	CDS	Rv2696c	NC_000962.2	3012829	3013608	R	Rv2696c, (MTCY05A6.17c), len: 259 aa. Conserved hypothetical ala-, gly-, val-rich protein, equivalent (but shorter 18 aa) to Q49993|ML1029|U1764K HYPOTHETICAL PROTEIN from Mycobacterium leprae (273 aa), FASTA scores: opt: 1174, E(): 2.1e-63, (70.6% identity in 262 aa overlap). Also similar to O54135|SC2E9.10 from Streptomyces coelicolor (250 aa), FASTA scores: opt: 213, E(): 9.8e-06, (28.25% identity in 255 aa overlap); and showing weak similarity with other proteins. TBparse score is 0.893.; hypothetical protein	complement(3012829..3013608)	Mycobacterium tuberculosis H37Rv	888482
NP_217213.1	CDS	dut	NC_000962.2	3013683	3014147	R	catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase	complement(3013683..3014147)	Mycobacterium tuberculosis H37Rv	887290
NP_217214.1	CDS	Rv2698	NC_000962.2	3014173	3014658	D	Rv2698, (MTCY05A6.19), len: 161 aa. Probable conserved ala-rich transmembrane protein, equivalent to Q49991|ML1027|U1764I POSSIBLE MEMBRANE PROTEIN from Mycobacterium leprae (157 aa), FASTA scores: opt: 886, E(): 1.1e-49, (78.9% identity in 161 aa overlap). Also similar to O54132|SC2E9.07c HYPOTHETICAL 16.5 KDA PROTEIN from Streptomyces coelicolor (154 aa), FASTA scores: opt: 230, E(): 7.1e-08, (35.7% identity in 154 aa overlap).; alanine rich transmembrane protein	3014173..3014658	Mycobacterium tuberculosis H37Rv	888528
NP_217215.1	CDS	Rv2699c	NC_000962.2	3014663	3014965	R	Rv2699c, (MTCY05A6.20c), len: 100 aa. Conserved hypothetical protein, very equivalent to Q49990|ML1026|U1764J HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa), FASTA scores: opt: 632, E(): 7.7e-36, (96.0% identity in 100 aa overlap). Also highly similar to O54130|SC2E9.05 HYPOTHETICAL 11.0 KDA PROTEIN from Streptomyces coelicolor (98 aa), FASTA scores: opt: 465, E(): 1.1e-24, (71.45% identity in 98 aa overlap). TBparse score is 0.912.; hypothetical protein	complement(3014663..3014965)	Mycobacterium tuberculosis H37Rv	887218
NP_217216.1	CDS	Rv2700	NC_000962.2	3015203	3015853	D	Rv2700, (MTCY05A6.21), len: 216 aa. Possible secreted ala-rich protein, equivalent to Q4998|ML1025|U1764H POSSIBLE SECRETED PROTEIN from Mycobacterium leprae (216 aa), FASTA scores: opt: 1198, E(): 1.2e-65, (82.4% identity in 216 aa overlap). Also showing some similarity with Q9AK75|2SCD60.08c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (204 aa), FASTA scores: opt: 193, E(): 8.9e-05, (31.25% identity in 192 aa overlap). TBparse score is 0.903.; secreted alanine rich protein	3015203..3015853	Mycobacterium tuberculosis H37Rv	887405
NP_217217.1	CDS	suhB	NC_000962.2	3015863	3016735	R	Rv2701c, (MTCY05A6.22c), len: 290 aa. Possible suhB, extragenic suppressor protein, equivalent to P46813|SUHB_MYCLE|SUHB|SSYA|ML1024 EXTRAGENIC SUPPRESSOR PROTEIN from Mycobacterium leprae (291 aa), FASTA scores: opt: 1424, E(): 4.9e-78, (77.55% identity in 294 aa overlap). Similar (except at N-terminus) to others e.g. O54128|SUHB from Streptomyces coelicolor (209 aa), FASTA scores: opt: 560, E(): 1.7e-26, (46.95% identity in 213 aa overlap); Q9CNV8|SUHB|PM0315 from Pasteurella multocida (267 aa), FASTA scores: opt: 479, E(): 1.5e-21, (39.3% identity in 234 aa overlap); P44333|SUHB_HAEIN|HI0937 from Haemophilus influenzae (267 aa), FASTA scores: opt: 438, E(): 4.1e-19, (34.7% identity in 248 aa overlap); P22783|SUHB_ECOLI|SSYA|B2533 from Escherichia coli strain K12 (267 aa), FASTA scores: opt: 419, E(): 5.7e-18, (34.45% identity in 267 aa overlap); etc. And also similar to putative myo-inositol-1(or 4)-monophosphatases e.g. Q9S1M1|SPCA from Streptoverticillium netropsis (Streptoverticillium flavopersicus) (266 aa), FASTA scores: opt: 556, E(): 3.6e-26, (45.4% identity in 240 aa overlap); Q9S3X5|SPCA from Streptomyces spectabilis (264 aa), FASTA scores: opt: 502, E(): 6.1e-23, (46.05% identity in 265 aa overlap); CAC47357 from Rhizobium meliloti (Sinorhizobium meliloti) (266 aa), FASTA scores: opt: 452, E(): 6e-20, (38.5% identity in 244 aa overlap); etc. Equivalent to AAK47090 from Mycobacterium tuberculosis strain CDC1551 (277 aa) but longer 13 aa. Contains PS00630 Inositol monophosphatase family signatures 1 and 2 (PS00629 and PS00630). BELONGS TO THE INOSITOL MONOPHOSPHATASE FAMILY. TBparse score is 0.906.; extragenic suppressor protein SuhB	complement(3015863..3016735)	Mycobacterium tuberculosis H37Rv	887210
NP_217218.1	CDS	ppgK	NC_000962.2	3016858	3017655	D	Rv2702, (MTCY05A6.23), len: 265 aa. ppgK, polyphosphate glucokinase (EC 2.7.1.2) (see citations below), equivalent, but shorter 60 aa, to Q49988|PPGK_MYCLE|ML1023|U1764FG POLYPHOSPHATE GLUCOKINASE from Mycobacterium leprae (324 aa), FASTA scores: opt: 1411, E(): 5.6e-80, (82.8% identity in 262 aa overlap). Also highly similar (or just similar) to others e.g. Q9ADE8|PPGK from Streptomyces coelicolor (246 aa), FASTA scores: opt: 912, E(): 3e-49, (57.3% identity in 239 aa overlap); Q9AGV8|PPGK from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (277 aa), FASTA scores: opt: 890, E(): 7.5e-48, (57.75% identity in 239 aa overlap); P40184|GLK_STRCO|SC6E10.20c from Streptomyces coelicolor (317 aa), FASTA scores: opt: 233, E(): 3.2e-07, (31.3% identity in 163 aa overlap); etc. TBparse score is 0.898.; polyphosphate glucokinase PPGK (polyphosphate-glucose phosphotransferase)	3016858..3017655	Mycobacterium tuberculosis H37Rv	887313
NP_217219.1	CDS	sigA	NC_000962.2	3017835	3019421	D	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor	3017835..3019421	Mycobacterium tuberculosis H37Rv	887477
NP_217220.1	CDS	Rv2704	NC_000962.2	3019458	3019886	D	Rv2704, (MTCY05A6.25), len: 142 aa. Conserved hypothetical protein, highly similar (but shorter 25 aa) to Q9RYB7|DR0033 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (157 aa), FASTA scores: opt: 381, E(): 1.5e-17, (54.85% identity in 124 aa overlap); and highly similar to various proteins e.g. CAC47758|SMC03796 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (126 aa), FASTA scores: opt: 302, E(): 1.4e-12, (46.6% identity in 126 aa overlap); Q98E55|MLL4402 from Rhizobium loti (Mesorhizobium loti) (130 aa), FASTA scores: opt: 252, E(): 2.1e-09, (40.15% identity in 127 aa overlap); Q9K3V5|SCD10.21 PUTATIVE ACETYLTRANSFERASE from Streptomyces coelicolor (291 aa), FASTA scores: opt: 247, E(): 8.7e-09, (41.3% identity in 138 aa overlap) (homology only in N-terminal region); etc. TBparse score is 0.905.; hypothetical protein	3019458..3019886	Mycobacterium tuberculosis H37Rv	887675
NP_217221.1	CDS	Rv2705c	NC_000962.2	3019814	3020203	R	Rv2705c, (MTCY05A6.26c), len: 129 aa (unlikely ORF). Conserved hypothetical protein, similar to others e.g. Q9RXR5|DR0242 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (112 aa), FASTA scores: opt: 259, E(): 9.4e-10, (40.5% identity in 116 aa overlap); CAC45122|SMC02246 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (115 aa), FASTA scores: opt: 208, E(): 1.6e-06, (38.3% identity in 107 aa overlap); Q98B88|MLL5682 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (116 aa), FASTA scores: opt: 173, E(): 0.00026, (34.95% identity in 103 aa overlap); etc.; hypothetical protein	complement(3019814..3020203)	Mycobacterium tuberculosis H37Rv	887302
NP_217222.1	CDS	Rv2706c	NC_000962.2	3020200	3020457	R	Rv2706c, (MTCY05A6.27c), len: 85 aa (unlikely ORF). Hypothetical unknown protein.; hypothetical protein	complement(3020200..3020457)	Mycobacterium tuberculosis H37Rv	887484
NP_217223.1	CDS	Rv2707	NC_000962.2	3020573	3021547	D	Rv2707, (MTCY05A6.28), len: 324 aa. Probable conserved transmembrane ala-, leu-rich protein, equivalent to Q49985|ML1017|U1764D POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (330 aa), FASTA scores: opt: 1617, E(): 2.5e-91, (75.4% identity in 325 aa overlap). Also similar to other membrane proteins e.g. Q9ADF6|SCBAC1A6.31 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (344 aa), FASTA scores: opt: 593, E(): 5.9e-29, (36.2% identity in 268 aa overlap); Q99SZ8|SA1699 HYPOTHETICAL PROTEIN (similar to transporter) from Staphylococcus aureus subsp. aureus N315 (405 aa), FASTA scores: opt: 318, E(): 3.7e-12, (27.9% identity in 265 aa overlap); O34437|YFKH HYPOTHETICAL PROTEIN (similar to transporter) from Bacillus subtilis (275 aa), FASTA scores: opt: 309, E(): 9.7e-12, (29.3% identity in 263 aa overlap); etc. TBparse score is 0.930.; hypothetical protein	3020573..3021547	Mycobacterium tuberculosis H37Rv	887750
NP_217224.1	CDS	Rv2708c	NC_000962.2	3021548	3021796	R	Rv2708c, (MTCY05A6.29), len: 82 aa. Conserved hypothetical protein, equivalent (but shorter 25 aa) to Q49984|ML1016|U1764C HYPOTHETICAL PROTEIN from Mycobacterium leprae (107 aa), FASTA scores: opt: 492, E(): 7.3e-27, (87.8% identity in 82 aa overlap). Also highly similar to Q9L1U7|SCE59.06c HYPOTHETICAL 10.4 KDA PROTEIN from Streptomyces coelicolor (97 aa), FASTA scores: opt: 200, E(): 4.4e-07, (51.6% identity in 62 aa overlap). TBparse score is 0.901.; hypothetical protein	complement(3021548..3021796)	Mycobacterium tuberculosis H37Rv	887159
NP_217225.1	CDS	Rv2709	NC_000962.2	3021839	3022285	D	Rv2709, (MTCY05A6.30), len: 148 aa. Probable conserved transmembrane protein, equivalent to Q9CCB4|ML1015 (alias Q49983|U1764B but extended in N-terminus) POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (139 aa), FASTA scores: opt: 578, E(): 5.5e-31, (70.75% identity in 123 aa overlap). Shows also similarity with Q9RJ48|SCI8.05 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (159 aa), FASTA scores: opt: 119, E(): 0.57, (31.95% identity in 119 aa overlap). TBscore is 0.892.; transmembrane protein	3021839..3022285	Mycobacterium tuberculosis H37Rv	887282
NP_217226.1	CDS	sigB	NC_000962.2	3022461	3023432	D	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB	3022461..3023432	Mycobacterium tuberculosis H37Rv	888580
NP_217227.1	CDS	ideR	NC_000962.2	3023565	3024257	D	Rv2711, (MTCY05A6.32), len: 230 aa. ideR (formerly known as dtxR), iron dependent repressor and activator (see citations below), equivalent to Q9CCB5|ML1013 IRON DEPENDENT REPRESSOR from Mycobacterium leprae (230 aa), FASTA scores: opt: 1365, E(): 3.8e-77, (90.0% identity in 230 aa overlap). Also highly similar to others e.g. Q50379|DTXR from Mycobacterium smegmatis (233 aa), FASTA scores: opt: 1291, E(): 1.4e-72, (86.1% identity in 230 aa overlap); Q9F7T3|IDER from Corynebacterium equii (Rhodococcus equi) (230 aa), FASTA scores: opt: 1130, E(): 1.2e-62, (74.8% identity in 230 aa overlap); P33120|DTXR_CORDI from Corynebacterium diphtheriae (226 aa), FASTA scores: opt: 803, E(): 1.6e-42, (57.85% identity in 230 aa overlap); etc. BELONGS TO THE FUR FAMILY. TBparse score is 0.876.; dtxR; IRON-dependent repressor and activator IDER	3023565..3024257	Mycobacterium tuberculosis H37Rv	888590
NP_217228.1	CDS	Rv2712c	NC_000962.2	3024270	3025328	R	Rv2712c, (MTCY05A6.33c), len: 352 aa. Hypothetical unknown ala-, leu-rich protein. TBparse score is 0.926.; hypothetical protein	complement(3024270..3025328)	Mycobacterium tuberculosis H37Rv	888586
NP_217229.1	CDS	sthA	NC_000962.2	3025441	3026847	D	catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase	3025441..3026847	Mycobacterium tuberculosis H37Rv	887355
NP_217230.1	CDS	Rv2714	NC_000962.2	3027065	3028039	D	Rv2714, (MTCY05A6.35), len: 324 aa. Conserved hypothetical ala-, leu-rich protein, equivalent to Q49847|ML1009|B2235_F1_6 HYPOTHETICAL PROTEIN from Mycobacterium leprae (326 aa), FASTA scores: opt: 1881, E(): 5.8e-107, (89.7% identity in 320 aa overlap); and similar to Q49797|MLCB2533.03c|B2126_F1_36 HYPOTHETICAL PROTEIN from Mycobacterium leprae (317 aa), FASTA scores: opt: 376, E(): 1.2e-15, (30.1% identity in 279 aa overlap); and Q9CC38|ML1306 HYPOTHETICAL PROTEIN from Mycobacterium leprae (274 aa), FASTA scores: opt: 367, E(): 3.6e-15, (29.8% identity in 275 aa overlap). Also highly similar to Q9S2K6|SC7H2.11c HYPOTHETICAL 34.2 KDA PROTEIN from Streptomyces coelicolor (312 aa), FASTA scores: opt: 770, E(): 1.4e-39, (40.9% identity in 286 aa overlap); and similar to Q9ADA5|SCI52.04 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (333 aa), FASTA scores: opt: 386, E(): 3e-16, (29.05% identity in 296 aa overlap). Also similar to O33260|Rv2125|MTCY261.21 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (292 aa), FASTA scores: opt: 387, E(): 2.3e-16, (29.45% identity in 292 aa overlap). TBparse score is 0.906.; hypothetical protein	3027065..3028039	Mycobacterium tuberculosis H37Rv	887653
NP_217231.1	CDS	Rv2715	NC_000962.2	3028098	3029123	D	Rv2715, (MTCY05A6.36), len: 341 aa. Possible hydrolase (EC 3.-.-.-), showing some similarity with other hydrolases e.g. Q9I5B0|PA0829 PROBABLE HYDROLASE from Pseudomonas aeruginosa (313 aa), FASTA scores: opt: 336, E(): 9.9e-14, (28.05% identity in 289 aa overlap); BAB55888 HYDROLASE (FRAGMENT) from Terrabacter sp. DBF63 (319 aa), FASTA scores: opt: 326, E(): 4.2e-13, (27.95% identity in 290 aa overlap); O52866|CEH|EH SOLUBLE EPOXIDE HYDROLASE from Corynebacterium SP (285 aa), FASTA scores: opt: 325, E(): 4.4e-13, (29.95% identity in 284 aa overlap); etc. Also shows some similarity to P96811|EPHF|Rv0134|MTCI5.08 HYPOTHETICAL 33.8 KDA PROTEINfrom Mycobacterium tuberculosis (300 aa), FASTA scores: E(): 1.8e-10, (27.7% identity in 271 aa overlap). Contains lipases, serine active site motif (PS00120). TBparse score is 0.915.; hydrolase	3028098..3029123	Mycobacterium tuberculosis H37Rv	887974
NP_217232.1	CDS	Rv2716	NC_000962.2	3029172	3029858	D	Rv2716, (MTCY05A6.37), len: 228 aa. Conserved hypothetical protein, similar to other proteins e.g. Q9RKR0|SCC75A.14 HYPOTHETICAL 23.3 KDA PROTEIN from Streptomyces coelicolor (214 aa), FASTA scores: opt: 447, E(): 4e-22, (44.1% identity in 220 aa overlap); Q9HHG6|PHZF|VNG6408G PHENAZINE BIOSYNTHETIC PROTEIN from Halobacterium sp. strain NRC-1 (299 aa), FASTA scores: opt: 201, E(): 6.1e-06, (30.4% identity in 148 aa overlap) (similarity only at N-terminus); P73125|SLR1019 HYPOTHETICAL 34.1 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (314 aa), FASTA scores: opt: 196, E(): 1.4e-05, (28.5% identity in 298 aa overlap); etc. TBparse score is 0.915.; hypothetical protein	3029172..3029858	Mycobacterium tuberculosis H37Rv	887775
NP_217233.1	CDS	Rv2717c	NC_000962.2	3029867	3030361	R	Rv2717c, (MTCY05A6.38c), len: 164 aa. Conserved hypothetical protein, equivalent to Q9CCB8|ML1006 (alias Q49838 but shortened N-terminus) HYPOTHETICAL PROTEIN from Mycobacterium leprae (161 aa), FASTA scores: opt: 797, E(): 2.3e-46, (73.8% identity in 164 aa overlap). Also highly similar to other eukaryotic proteins e.g. O64527|YUP8H12R.14 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (166 aa), FASTA scores: opt: 393, E(): 2.3e-19, (42.4% identity in 158 aa overlap); Q9Y325 CGI-36 PROTEIN from Homo sapiens (Human) (165 aa), FASTA scores: opt: 294, E(): 9.5e-13, (33.95% identity in 159 aa overlap); etc. TBparse score is 0.937.; hypothetical protein	complement(3029867..3030361)	Mycobacterium tuberculosis H37Rv	887284
NP_217234.1	CDS	nrdR	NC_000962.2	3030413	3030877	R	Rv2718c, (MTCY05A6.39c), len: 154 aa. Conserved hypothetical protein, equivalent to Q49844|ML1005|U2235A|B2235_C2_209 HYPOTHETICAL 17.3 KDA PROTEIN from Mycobacterium leprae (154 aa), FASTA scores: opt: 937, E(): 1.5e-52, (92.7% identity in 151 aa overlap). Highly similar to O86848|NRDR_STRCL PUTATIVE REGULATORY PROTEIN from Streptomyces clavuligerus (172 aa), FASTA scores: opt: 750, E(): 1.1e-40, (73.65% identity in 148 aa overlap); O69980|SC4H2.25 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (182 aa), FASTA scores: opt: 725, E(): 4.6e-39, (73.1% identity in 145 aa overlap); Q9KPU0|VC2272 HYPOTHETICAL PROTEIN from Vibrio cholerae (156 aa), FASTA scores: opt: 462, E(): 1.8e-22, (47.3% identity in 148 aa overlap); etc. TBparse score is 0.933.; transcriptional regulator NrdR	complement(3030413..3030877)	Mycobacterium tuberculosis H37Rv	887985
NP_217235.1	CDS	Rv2719c	NC_000962.2	3031040	3031537	R	Rv2719c, (MTCY05A6.40c), len: 165 aa. Possible conserved membrane protein, equivalent to Q49846|ML1004|B2235_C3_243 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (164 aa), FASTA scores: opt: 486, E(): 4e-21, (55.2% identity in 163 aa overlap).; hypothetical protein	complement(3031040..3031537)	Mycobacterium tuberculosis H37Rv	887959
NP_217236.1	CDS	lexA	NC_000962.2	3031845	3032498	D	Represses a number of genes involved in the response to DNA damage; LexA repressor	3031845..3032498	Mycobacterium tuberculosis H37Rv	888169
NP_217237.1	CDS	Rv2721c	NC_000962.2	3032520	3034619	R	Rv2721c, (MTCY05A6.42c, MTCY154.01c), len: 699 aa. Possible conserved transmembrane ala-, gly-rich protein, equivalent to Q49837|ML1002|U2235I POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (687 aa), FASTA scores: opt: 2703, E(): 6.6e-135, (60.3% identity in 713 aa overlap). Shows some similaity to Q01377|CSP1 PS1 PROTEIN PRECURSOR (SECRETED PROTEIN) from Corynebacterium glutamicum (Brevibacterium flavum) (657 aa), FASTA scores: opt: 276, E(): 3.8e-07, (29.4% identity in 272 aa overlap); and Q9KIJ0 Rv2721c-LIKE PROTEIN from Mycobacterium paratuberculosis (246 aa), FASTA scores: opt: 178, E(): 0.025, (37.5% identity in 120 aa overlap). TBparse score is 0.927.; hypothetical protein	complement(3032520..3034619)	Mycobacterium tuberculosis H37Rv	888291
NP_217238.1	CDS	Rv2722	NC_000962.2	3034635	3034883	D	Rv2722, (MTCY154.02), len: 82 aa. Conserved hypothetical protein, similar to Q9CCB9|ML1001 HYPOTHETICAL PROTEIN from Mycobacterium leprae (91 aa), FASTA scores: opt: 154, E(): 0.00053, (37.5% identity in 88 aa overlap). Equivalent to AAK47111 from Mycobacterium tuberculosis strain CDC1551 (94 aa) but shorter 12 aa.; hypothetical protein	3034635..3034883	Mycobacterium tuberculosis H37Rv	888399
NP_217239.1	CDS	Rv2723	NC_000962.2	3034909	3036102	D	Rv2723, (MTCY154.03), len: 397 aa. Probable conserved integral membrane protein, highly similar to others e.g. Q9Z503|SCC54.23c PUTATIVE INTEGRAL MEMBRANE EXPORT PROTEIN from Streptomyces coelicolor (333 aa), FASTA scores: opt: 883, E(): 2.4e-48, (46.4% identity in 332 aa overlap); Q9RD18|SCM1.25c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (316 aa), FASTA scores: opt: 865, E(): 3.1e-47, (47.55% identity in 324 aa overlap); P96554|Y319_MYXXA INTEGRAL MEMBRANE PROTEIN (PROBABLE) from Myxococcus xanthus (319 aa), FASTA scores: opt: 626, E(): 3.4e-32, (34.65% identity in 323 aa overlap); P42601|YGJT_ECOLI|B3088 from Escherichia coli strain K12 INTEGRAL MEMBRANE PROTEIN (PROBABLE) (321 aa), FASTA scores: opt: 541, E(): 7.7e-27, (35.1% identity in 279 aa overlap); etc.; integral membrane protein	3034909..3036102	Mycobacterium tuberculosis H37Rv	887768
NP_217240.1	CDS	fadE20	NC_000962.2	3036131	3037291	R	Rv2724c, (MTCY154.04c), len: 386 aa. Probable fadE20, acyl-CoA dehydrogenase (EC 1.3.99.-), highly similar to many e.g. Q9X7Y2|SC6A5.36 from Streptomyces coelicolor (382 aa), FASTA scores: opt: 1583, E(): 6.9e-94, (62.7% identity in 378 aa overlap); Q9HVY0|PA4435 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 1468, E(): 1.6e-86, (57.65% identity in 380 aa overlap); Q9ABZ1|CC0079 from Caulobacter crescentus (391 aa), FASTA scores: opt: 1298, E(): 1.2e-75, (51.9% identity in 391 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis proteins e.g. O06164|FADE19|Rv2500c|MTCY07A7.06c ACYL-CoA DEHYDROGENASE (394 aa) (34.3% identity in 382 aa overlap). Contains acyl-CoA dehydrogenases signature 2 (PS00073). BELONGS TO THE ACYL-CoA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE20	complement(3036131..3037291)	Mycobacterium tuberculosis H37Rv	887866
NP_217241.1	CDS	hflX	NC_000962.2	3037427	3038914	R	Rv2725c, (MTCY154.05c), len: 495 aa. Probable hflX (hfl for high frequency of lysogenization), GTP-binding protein (EC 3.1.5.-),equivalent to Q9CCC0|ML0997 (alias Q49843|HFLX but longer) POSSIBLE ATP/GTP-BINDING PROTEIN from Mycobacterium leprae (488 aa), FASTA scores: opt: 2562, E(): 1.1e-133, (84.55% identity in 485 aa overlap). Also highly similar to many e.g. Q9XCC1 from Streptomyces fradiae (425 aa), FASTA scores: opt: 1280, E(): 3.2e-63, (57.7% identity in 423 aa overlap); P73965|HFLX|SLR1521 from Synechocystis sp. strain PCC 6803 (534 aa), FASTA scores: opt: 1028, E(): 2.8e-49, (44.7% identity in 414 aa overlap); P25519|HFLX_ECOLI|B4173 from Escherichia coli strain K12 (426 aa), FASTA scores: opt: 916, E(): 3.4e-43, (40.1% identity in 414 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; GTP-binding protein HflX	complement(3037427..3038914)	Mycobacterium tuberculosis H37Rv	888241
NP_217242.1	CDS	dapF	NC_000962.2	3038931	3039800	R	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase	complement(3038931..3039800)	Mycobacterium tuberculosis H37Rv	888614
NP_217243.1	CDS	miaA	NC_000962.2	3039825	3040769	R	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase	complement(3039825..3040769)	Mycobacterium tuberculosis H37Rv	887242
NP_217244.1	CDS	Rv2728c	NC_000962.2	3040766	3041461	R	Rv2728c, (MTCY154.08c), len: 231 aa. Conserved hypothetical ala-rich protein, equivalent to Q49835|ML0994|B2235_C1_162 HYPOTHETICAL PROTEIN from Mycobacterium leprae (232 aa), FASTA scores: opt: 1037, E(): 1.2e-54, (68.55% identity in 232 aa overlap). Also similar to O69964|SC4H2.09 from Streptomyces coelicolor (237 aa), FASTA scores: opt: 300, E(): 7.7e-11, (32.8% identity in 241 aa overlap); and some similarity with other proteins e.g. Q14234|ELN ELASTIN from Homo sapiens (Human) (757 aa), FASTA scores: opt: 161, E(): 0.03, (30.6% identity in 242 aa overlap); P55488|Y4IE HYPOTHETICAL 15.4 KDA PROTEIN from Rhizobium sp. strain NGR234 (135 aa), FASTA scores: opt: 147, E(): 0.061, (34.95% identity in 123 aa overlap). Shows also some similarity with P71657|Rv1387|MTCY21B4.04 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (539 aa), FASTA scores: opt: 159, E(): 0.035, (34.8% identity in 135 aa overlap).; hypothetical protein	complement(3040766..3041461)	Mycobacterium tuberculosis H37Rv	888330
NP_217245.1	CDS	Rv2729c	NC_000962.2	3041570	3042475	R	Rv2729c, (MTCY154.09c), len: 301 aa. Probable conserved integral membrane ala-, val-, leu-rich protein, similar to P42459|YLEU_CORGL HYPOTHETICAL 29.6 KDA PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum)(270 aa), FASTA scores: opt: 365, E(): 4.7e-15, (30.75% identity in 221 aa overlap); and to other integral membrane proteins (principally from Streptomyces sp.) e.g. Q9EWZ8|2SCG38.21 from Streptomyces coelicolor (302 aa), FASTA scores: opt: 365, E(): 5.2e-15, (32.0% identity in 278 aa overlap); Q9S267|SCI30A.06 from Streptomyces coelicolor (297 aa), FASTA scores: opt: 356, E(): 1.8e-14, (31.5% identity in 289 aa overlap); AAK81278|CAC3346 from Clostridium acetobutylicum (472 aa), FASTA scores: opt: 154, E(): 0.038, (24.1% identity in 224 aa overlap); etc.; hypothetical protein	complement(3041570..3042475)	Mycobacterium tuberculosis H37Rv	888333
NP_217246.1	CDS	Rv2730	NC_000962.2	3042542	3043018	D	Rv2730, (MTCY174.10), len: 158 aa. Hypothetical unknown protein.; hypothetical protein	3042542..3043018	Mycobacterium tuberculosis H37Rv	888323
NP_217247.1	CDS	Rv2731	NC_000962.2	3043026	3044378	D	Rv2731, (MTCY174.11), len: 450 aa. Conserved hypothetical ala-, arg-rich protein, highly similar in part to Q49849|B2235_F2_77 HYPOTHETICAL PROTEIN from Mycobacterium leprae (266 aa), FASTA scores: opt: 368, E(): 1e-10, (73.5% identity in 83 aa overlap); and Q9KXN9|SC9C5.35 HYPOTHETICAL 6.5 KDA PROTEIN (FRAGMENT) from Streptomyces coelicolor (58 aa), FASTA scores: opt: 214, E(): 0.00065, (51.7% identity in 58 aa overlap). Also similar to Q9L296|SCL2.01 HYPOTHETICAL 37.4 KDA PROTEIN (FRAGMENT) from Streptomyces coelicolor (328 aa), FASTA scores: opt: 843, E(): 3.7e-33, (45.95% identity in 296 aa overlap) (but N-terminus shorter); and shows some similarity with other proteins e.g. Q26938 KINETOPLAST-ASSOCIATED PROTEIN (KAP) from Trypanosoma cruzi (1052 aa), FASTA scores: opt: 223, E(): 0.0022, (30.3% identity in 297 aa overlap). Start site chosen by RBS and to avoid overlap, although there are several other possible start sites further upstream.; hypothetical protein	3043026..3044378	Mycobacterium tuberculosis H37Rv	888300
NP_217248.1	CDS	Rv2732c	NC_000962.2	3044375	3044989	R	Rv2732c, (MTCY174.12c), len: 204 aa. Probable conserved transmembrane protein, similar to Q49834 hypothetical protein B2235_C1_155 from Mycobacterium leprae (209 aa), FASTA scores: opt: 932, E(): 0, (70.6% identity in 201 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.; transmembrane protein	complement(3044375..3044989)	Mycobacterium tuberculosis H37Rv	888319
NP_217249.1	CDS	Rv2733c	NC_000962.2	3044986	3046524	R	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase	complement(3044986..3046524)	Mycobacterium tuberculosis H37Rv	888266
NP_217250.1	CDS	Rv2734	NC_000962.2	3046821	3047675	D	Rv2734, (MTCY154.14), len: 284 aa. Conserved hypothetical protein, highly similar to various proteins e.g. Q984J2|MLR7981 ABC TRANSPORTER ATP-BINDING PROTEIN from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 877, E(): 9e-50, (52.45% identity in 246 aa overlap) (N-terminus longer); Q98DH1|MLL4707 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (249 aa), FASTA scores: opt: 829, E(): 1.1e-46, (50.4% identity in 244 aa overlap); AAK65865|SMA2239 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (259 aa), FASTA scores: opt: 796, E(): 1.5e-44, (50.0% identity in 252 aa overlap); etc.; hypothetical protein	3046821..3047675	Mycobacterium tuberculosis H37Rv	888303
NP_217251.1	CDS	Rv2735c	NC_000962.2	3047560	3048552	R	Rv2735c, (MTCY154.15c), len 330 aa. Conserved hypothetical protein, showing some similarity with Q98DH2|MLR4706 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (302 aa), FASTA scores: opt: 140, E(): 0.062, (27.0% identity in 200 aa overlap); and Q9PHA1|XF0043 HYPOTHETICAL PROTEIN from Xylella fastidiosa (293 aa), FASTA scores: opt: 120, E(): 1.2, (30.75% identity in 117 aa overlap).; hypothetical protein	complement(3047560..3048552)	Mycobacterium tuberculosis H37Rv	888389
NP_217252.1	CDS	recX	NC_000962.2	3048562	3049086	R	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX	complement(3048562..3049086)	Mycobacterium tuberculosis H37Rv	888393
NP_217253.1	CDS	recA	NC_000962.2	3049052	3051424	R	these RecA proteins contain inteins; catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; DNA recombination protein RecA	complement(3049052..3051424)	Mycobacterium tuberculosis H37Rv	888371
YP_177676.1	CDS	Rv2737A	NC_000962.2	3051619	3051792	D	Rv2737A, len 57 aa. Conserved hypothetical cys-rich protein (possibly gene fragment), similar to central part of AJ243803_1|glgA from Streptomyces coelicolor glgA (181 aa), FASTA scores: opt: 210, E(): 6.1e-09, (59.25% identity in 54 aa overlap).; hypothetical protein	3051619..3051792	Mycobacterium tuberculosis H37Rv	3205037
NP_217254.1	CDS	Rv2738c	NC_000962.2	3051806	3052012	R	Rv2738c, (MTV002.03c), len: 68 aa. Conserved hypothetical protein, equivalent to Q9CCC1|ML0986 HYPOTHETICAL PROTEIN from Mycobacterium leprae (67 aa), FASTA scores: opt: 397, E(): 3.7e-22, (83.6% identity in 67 aa overlap). Also highly similar to O50484|SC4H8.05 HYPOTHETICAL 7.5 KDA PROTEIN from Streptomyces coelicolor (64 aa), FASTA scores: opt: 185, E(): 5.9e-07, (39.7% identity in 63 aa overlap). Second part of the protein is highly similar to C-terminus of upstream ORF O33285|Rv2742c|MTV002.07c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (277 aa), FASTA scores: opt: 200, E(): 1.7e-07, (78.4% identity in 37 aa overlap).; hypothetical protein	complement(3051806..3052012)	Mycobacterium tuberculosis H37Rv	888368
NP_217255.1	CDS	Rv2739c	NC_000962.2	3052023	3053189	R	Rv2739c, (MTV002.04c), len: 388 aa. Possible ala-rich transferase (EC 2.-.-.-), equivalent to Q49841|ML0985|MLCB33.02c|U2235C POSSIBLE GLYCOSYLTRANSFERASE from Mycobacterium leprae (392 aa), FASTA scores: opt: 2112, E(): 5.1e-114, (80.95% identity in 388 aa overlap). Shows some similarity with other transferases e.g. Q9S1V2|SCJ4.21 PUTATIVE GLYCOSYL TRANSFERASE from Streptomyces coelicolor (407 aa), FASTA scores: opt: 290, E(): 2e-09, (27.75% identity in 382 aa overlap); Q9RYI3|DRA0329 PUTATIVE GLYCOSYLTRANSFERASE from Deinococcus radiodurans (418 aa), FASTA scores: opt: 267, E(): 4.3e-08, (29.05% identity in 396 aa overlap); P96560|GTFC GLYCOSYLTRANSFERASE from Amycolatopsis orientalis (409 aa), FASTA scores: opt: 253, E(): 2.7e-07, (27.75% identity in 418 aa overlap); etc. Equivalent to AAK47130 from Mycobacterium tuberculosis strain CDC1551 (420 aa) but shorter 32 aa.; alanine rich transferase	complement(3052023..3053189)	Mycobacterium tuberculosis H37Rv	888363
NP_217256.1	CDS	Rv2740	NC_000962.2	3053233	3053682	D	Rv2740, (MTV002.05), len: 149 aa. Conserved hypothetical protein, equivalent, but shorter 17 aa, to Q9CCC2|ML0984 (alias Q49850 but longer) HYPOTHETICAL PROTEIN from Mycobacterium leprae (164 aa), FASTA scores: opt: 481, E(): 9.7e-26, (52.0% identity in 150 aa overlap).; hypothetical protein	3053233..3053682	Mycobacterium tuberculosis H37Rv	888365
YP_177902.1	CDS	PE_PGRS47	NC_000962.2	3053914	3055491	D	Rv2741, (MTV002.06), len: 525 aa. Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to others e.g. Q10637|YD25_MYCTU|Rv1325c|MT1367|MTCY130.10c HYPOTHETICAL PE-PGRS FAMILY PROTEIN (603 aa), FASTA scores: opt: 1936, E(): 1.1e-71, (56.95% identity in 611 aa overlap).; PE-PGRS family protein	3053914..3055491	Mycobacterium tuberculosis H37Rv	888339
NP_217258.1	CDS	Rv2742c	NC_000962.2	3055515	3056348	R	Rv2742c, (MTV002.07c), len: 277 aa (questionable ORF). Conserved hypothetical arg-rich protein. Extreme N-terminus is highly similar to the N-teminus of Q9CCC1ML0986 HYPOTHETICAL PROTEIN from Mycobacterium leprae (67 aa), FASTA scores: opt: 183, E(): 0.00052, (71.05% identity in 38 aa overlap); and to the downstream ORF O33281|Rv2738c|MTV002.03c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (68 aa), FASTA scores: opt: 200, E(): 5.5e-05, (78.4% identity in 37 aa overlap).; hypothetical protein	complement(3055515..3056348)	Mycobacterium tuberculosis H37Rv	888332
NP_217259.1	CDS	Rv2743c	NC_000962.2	3056420	3057232	R	Rv2743c, (MTV002.08c), len: 270 aa. Possible conserved transmembrane ala-rich protein, equivalent to Q49833|MLCB33.04c|B2235_C1_148 UNKNOWN PROTEIN from Mycobacterium leprae (123 aa), FASTA scores: opt: 639, E(): 3.3e-31, (74.8% identity in 123 aa overlap).; hypothetical protein	complement(3056420..3057232)	Mycobacterium tuberculosis H37Rv	887779
YP_177903.1	CDS	35kd_ag	NC_000962.2	3057251	3058063	R	Rv2744c, (MTV002.09c), len: 270 aa. 35kd_ag, conserved ala-rich protein 35-kd antigen (see O'Connor et al., 1990). N-terminal part is equivalent to Q49840|MLCB33.06c|B2235_C2_187 HYPOTHETICAL PROTEIN from Mycobacterium leprae (167 aa), FASTA scores: opt: 789, E(): 3.4e-35, (85.05% identity in 147 aa overlap); and C-terminal part equivalent to Q49845|MLCB33.05c|B2235_C3_214 HYPOTHETICAL PROTEIN from Mycobacterium leprae (114 aa), FASTA scores: opt: 465, E(): 3.6e-18, (65.8% identity in 114 aa overlap); note that these two proteins from Mycobacterium leprae are adjacent. Shows some similarity with Q55707||Y617_SYNY3|SLL0617 HYPOTHETICAL 28.9 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (267 aa), FASTA scores: opt: 155, E(): 0.19, (23.4% identity in 252 aa overlap); and C-terminus of Q9L4N1|EMM M PROTEIN from Streptococcus equisimilis (592 aa), FASTA scores: opt: 165, E(): 0.11, (23.45% identity in 260 aa overlap). C-terminus also similar to AAK45945|MT1676 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (85 aa), FASTA scores: opt: 159, E(): 0.047, (50.9% identity in 55 aa overlap).; hypothetical protein	complement(3057251..3058063)	Mycobacterium tuberculosis H37Rv	888304
NP_217261.1	CDS	Rv2745c	NC_000962.2	3058193	3058531	R	Rv2745c, (MTV002.10c), len: 112 aa. Possible transcriptional regulatory protein, highly similar to O86815|SC7C7.10 HYPOTHETICAL 13.6 KDA PROTEIN from Streptomyces coelicolor (126 aa), FASTA scores: opt: 300, E(): 2.4e-13, (60.45% identity in 86 aa overlap); and highly similar to other transcriptional regulators e.g. Q9X7S1|SC5H1.13c POSSIBLE DNA-BINDING PROTEIN from Streptomyces coelicolor (157 aa), FASTA scores: opt: 254, E(): 3.3e-10, (50.0% identity in 94 aa overlap) (N-terminus longer); Q9F885|POPR TRANSCRIPTIONAL REGULATOR from Streptomyces lividans (148 aa), FASTA scores: opt: 248, E(): 7.8e-10, (53.6% identity in 97 aa overlap) (N-terminus longer); Q9FCH1|2SCD46.12 PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (141 aa), FASTA scores: opt: 162, E(): 0.00038, (33.0% identity in 106 aa overlap); etc.; transcriptional regulatory protein	complement(3058193..3058531)	Mycobacterium tuberculosis H37Rv	888315
NP_217262.1	CDS	pgsA3	NC_000962.2	3058602	3059231	R	Rv2746c, (MTV002.11c), len: 209 aa. Probable pgsA3, PGP synthase (EC 2.7.8.5) (see citation below), transmembrane protein, equivalent, but longer 19 aa, to Q49839|O08087|PGSA|ML0979 PGSA from Mycobacterium leprae (193 aa), FASTA scores: opt: 925, E(): 3.7e-53, (77.15% identity in 188 aa overlap). Also highly similar to O86813|PGSA PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE from Streptomyces coelicolor (263 aa), FASTA scores: opt: 692, E(): 6.6e-38, (57.85% identity in 185 aa overlap) (has its N-terminus longer); and similar to others (generally with N-terminus shorter) e.g. Q99XI0|PGSA|SPY2196 PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE from Streptococcus pyogenes (180 aa), FASTA scores: opt: 368, E(): 5.4e-17, (39.9% identity in 168 aa overlap); Q9ZE96|PGSA_RICPR|PGSA|RP049 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3- PHOSPHATIDYLTRANSFERASE from Rickettsia prowazekii (181 aa), FASTA scores: opt: 343, E(): 2.3e-15, (40.1% identity in 172 aa overlap); P06978|PGSA_ECOLI|PGSA|B1912|Z3000|ECS2650 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3- PHOSPHATIDYLTRANSFERASE from Escherichia coli strains K12 and O157:H7 (181 aa), FASTA scores: opt: 322, E(): 5.3e-14, (34.45% identity in 180 aa overlap); etc. Also some similarity to PGSA2|Rv1822|MTCY1A11.21c PROBABLE CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE from Mycobacterium tuberculosis (209 aa), FASTA score: (27.1% identity in 166 aa overlap). Contains PS00379 CDP-alcohol phosphatidyltransferases signature. BELONGS TO THE CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE CLASS-I FAMILY.; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	complement(3058602..3059231)	Mycobacterium tuberculosis H37Rv	888375
NP_217263.1	CDS	Rv2747	NC_000962.2	3059262	3059786	D	catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase	3059262..3059786	Mycobacterium tuberculosis H37Rv	888407
NP_217264.1	CDS	ftsK	NC_000962.2	3059855	3062506	R	Rv2748c, (MTV002.13c), len: 883 aa. Possible ftsK, cell division transmembrane protein, equivalent to O05560|ML0977|FTSK|MLCB33.09c CELL DIVISION PROTEIN from Mycobacterium leprae (886 aa), FASTA scores: opt: 3147, E(): 7.9e-175, (78.1% identity in 885 aa overlap). Also similar to other members of the spoIIIE/ftsK family e.g. O86810|SC7C7.05 FTSK HOMOLOG from Streptomyces coelicolor (929 aa), FASTA scores: opt: 2256, E(): 3.8e-123, (49.05% identity in 924 aa overlap); Q9CF25|FTSK CELL DIVISION PROTEIN FTSK from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (763 aa), FASTA scores: opt: 1438, E(): 9.1e-76, (37.7% identity in 751 aa overlap); AAK75005|Q97RE4|SP0878 SPOE FAMILY PROTEIN from Streptococcus pneumoniae (767 aa), FASTA scores: opt: 1405, E(): 7.5e-74, (48.0% identity in 477 aa overlap); P46889|FTSK_ECOLI|B0890 from Escherichia coli strain K12 (1329 aa), FASTA scores: opt: 759, E(): 0, (44.5% identity in 537 aa overlap) (similarity in C-terminal half); etc. Equivalent to AAK47139 from Mycobacterium tuberculosis strain CDC1551 (968 aa) but shorter 85 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE FTSK/SPOIIIE FAMILY.; cell division transmembrane protein FtsK	complement(3059855..3062506)	Mycobacterium tuberculosis H37Rv	888408
NP_217265.1	CDS	Rv2749	NC_000962.2	3062505	3062819	D	Rv2749, (MTV002.14), len: 104 aa. Conserved hypothetical protein, showing some similarity with Q9I1R9|PA2198 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (114 aa), FASTA scores: opt: 157, E(): 0.00081, (35.0% identity in 100 aa overlap); and O86332|Rv0793|MTV042.03 HYPOTHETICAL 11.2 KDA PROTEIN from Mycobacterium tuberculosis (101 aa), FASTA scores: opt: 143, E(): 0.0062, (26.9% identity in 93 aa overlap).; hypothetical protein	3062505..3062819	Mycobacterium tuberculosis H37Rv	888390
NP_217266.1	CDS	Rv2750	NC_000962.2	3062816	3063634	D	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase	3062816..3063634	Mycobacterium tuberculosis H37Rv	888384
NP_217267.1	CDS	Rv2751	NC_000962.2	3063638	3064528	D	Rv2751, (MTV002.16), len: 296 aa. Conserved hypothetical protein, similar in part to others e.g. Q98LR1|MLR0915 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (299 aa), FASTA scores: opt: 279, E(): 1.6e-11, (32.85% identity in 210 aa overlap); Q9FBX1|SC8E7.10 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (283 aa), FASTA scores: opt: 232, E(): 2.4e-08, (27.9% identity in 269 aa overlap); Q9FMY9 HYPOTHETICAL PROTEIN (GENOMIC DNA, CHROMOSOME 5, P1 CLONE:MJB21) from Arabidopsis thaliana (Mouse-ear cress) (370 aa), FASTA scores: opt: 205, E(): 2.1e-06, (28.9% identity in 211 aa overlap); etc. Also similar in part to several proteins from Mycobacterium tuberculosis: P72053|Rv3787c|MTCY13D12.21 HYPOTHETICAL 33.4 KDA PROTEIN (308 aa), FASTA scores: opt: 266, E(): 1.3e-10, (29.6% identity in 267 aa overlap); O53795|MBE50c|Rv0731c|MTV041.05c HYPOTHETICAL 34.9 KDA PROTEIN (318 aa), FASTA scores: opt: 266, E(): 1.3e-10, (32.05% identity in 281 aa overlap); O53841|Rv0830|MTV043.22 HYPOTHETICAL 33.4 KDA PROTEIN (301 aa), FASTA scores: opt: 263, E(): 2e-10, (31.3% identity in 262 aa overlap); etc. BELONGS TO THE MTCY13D12.21 / MTCY210.45C / MTCY78.29C FAMILY.; hypothetical protein	3063638..3064528	Mycobacterium tuberculosis H37Rv	887806
NP_217268.1	CDS	Rv2752c	NC_000962.2	3064515	3066191	R	Rv2752c, (MTV002.17c), len: 558 aa. Conserved hypothetical protein, equivalent to Q9CBW5|ML1512 HYPOTHETICAL PROTEIN from Mycobacterium leprae (558 aa), FASTA scores: opt: 3301, E(): 1.2e-195, (89.05% identity in 558 aa overlap). Also highly similar to other hypothetical proteins from a wide range of prokaryotes e.g. CAC19480|P54122|YOR4_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (718 aa), FASTA scores: opt: 2142, E(): 3.5e-124, (57.2% identity in 554 aa overlap) (N-terminus longer); O86842|SC9A10.09 from Streptomyces coelicolor (561 aa), FASTA scores: opt: 2077, E(): 2.9e-120, (55.95% identity in 556 aa overlap); Q9ZI80 from Streptomyces toyocaensis (528 aa), FASTA scores: opt: 1843, E(): 7.3e-106, (52.45% identity in 528 aa overlap) (N-terminus shorter 30 aa); etc.; hypothetical protein	complement(3064515..3066191)	Mycobacterium tuberculosis H37Rv	887802
NP_217269.1	CDS	dapA	NC_000962.2	3066222	3067124	R	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase	complement(3066222..3067124)	Mycobacterium tuberculosis H37Rv	888289
NP_217270.1	CDS	thyX	NC_000962.2	3067193	3067945	R	flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase	complement(3067193..3067945)	Mycobacterium tuberculosis H37Rv	887766
YP_177904.1	CDS	hsdS.1	NC_000962.2	3068189	3068464	R	Rv2755c, (MTV002.20c), len: 91 aa. Possible hsdS.1, fragment of type I restriction/modification system specificity determinant (S protein), similar to the N-terminus of other hsdS proteins e.g. O34140|HSDS from Klebsiella pneumoniae (439 aa), FASTA scores: opt: 303, E(): 2.1e-13, (46.65% identity in 90 aa overlap); P72419|STY|SBLI from Salmonella typhimurium (434 aa), FASTA scores: opt: 278, E(): 1.1e-11, (47.65% identity in 86 aa overlap); and Q9P9X9|XF2741 from Xylella fastidiosa (412 aa), FASTA scores: opt: 144, E(): 0.015, (31.7% identity in 82 aa overlap). Also some similarity with O33303|Rv2761c|MTV002.26c|HSDS POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM SPECIFICITY DETERMINANT from Mycobacterium tuberculosis (364 aa), FASTA scores: opt: 145, E(): 0.012, (29.9% identity in 87 aa overlap). Note that previously known as hsdS'.; hsdS'; type I restriction/modification system specificity determinant HsdS	complement(3068189..3068464)	Mycobacterium tuberculosis H37Rv	887776
NP_217272.1	CDS	hsdM	NC_000962.2	3068461	3070083	R	Rv2756c, (MTV002.21c), len: 540 aa. Possible hsdM, type I restriction/modification system DNA methylase (M protein) (EC 2.1.1.-), highly similar to others e.g. Q9P9X8|XF2742 from Xylella fastidiosa (519 aa), FASTA scores: opt: 1613, E(): 1.9e-96, (52.3% identity in 543 aa overlap); O34139|HSDM from Klebsiella pneumoniae (539 aa), FASTA scores: opt: 1267, E(): 4.4e-74, (45.9% identity in 549 aa overlap); P72418|STY|SBLI|HSDM from Salmonella typhimurium (539 aa), FASTA scores: opt: 1263, E(): 8e-74, (45.7% identity in 549 aa overlap); etc. Possible alternative start site (GTG) overlapping with termination codon of previous ORF 90 bp upstream. Note that the corresponding endonuclease (M protein) does not appear to be present in Mycobacterium tuberculosis.; type I restriction/modification system DNA methylase HsdM	complement(3068461..3070083)	Mycobacterium tuberculosis H37Rv	888278
NP_217273.1	CDS	Rv2757c	NC_000962.2	3070170	3070586	R	Rv2757c, (MTV002.22c), len: 138 aa. Conserved hypothetical protein, similar to several other M. tuberculosis hypothetical proteins e.g. P96411|Rv0229c| MTCY08D5.24c (226 aa), FASTA scores: opt: 354, E(): 4.6e-18, (45.25% identity in 137 aa overlap) (N-terminus longer 89 aa); P95007|RV2546|MTCY159.10c (137 aa), FASTA scores: opt: 265, E(): 7.5e-12, (38.5% identity in 135 aa overlap); O07228|Rv0301|MTCY63.06 (141 aa), FASTA scores: opt: 259, E(): 2.1e-11, (42.4% identity in 132 aa overlap); etc.; hypothetical protein	complement(3070170..3070586)	Mycobacterium tuberculosis H37Rv	888249
NP_217274.1	CDS	Rv2758c	NC_000962.2	3070583	3070849	R	Rv2758c, (MTV002.23c), len: 88 aa. Conserved hypothetical protein, similar to several other M. tuberculosis hypothetical proteins e.g. P95008|Rv2545 (92 aa), FASTA scores: opt: 151, E(): 0.00028, (66.65% identity in 45 aa overlap); Q10771|YF60_MYCTU|RV1560|MT1611|MTCY48.05c (72 aa), FASTA scores: opt: 106, E(): 0.52, (39.15% identity in 46 aa overlap); O06565|Rv1113|MTCY22G8.02 (65 aa), FASTA scores: opt: 97, E(): 2.2, (33.35% identity in 69 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.; hypothetical protein	complement(3070583..3070849)	Mycobacterium tuberculosis H37Rv	888263
NP_217275.1	CDS	Rv2759c	NC_000962.2	3070875	3071270	R	Rv2759c, (MTV002.24c), len: 131 aa. Conserved hypothetical protein, highly similar to three M. tuberculosis hypothetical proteins O07769|Y609_MYCTU|Rv0609|MT0638|MTCY19H5.13c (133 aa), FASTA scores: opt: 364, E(): 5.1e-18, (49.6% identity in 131 aa overlap); P96914|Y624_MYCTU|Rv0624|MT0652|MTCY20H10.05 (131 aa), FASTA scores: opt: 324, E(): 2.9e-15, (42.85% identity in 126 aa overlap); and Q10874|YJ82_MYCTU|Rv1982c|MT2034|MTCY39.37 (139 aa), FASTA scores: opt: 271, E(): 1.4e-11, (38.6% identity in 127 aa overlap). Also similar to other hypothetical proteins from other bacteria e.g. CAC45376|SMC00900 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (128 aa), FASTA scores: opt: 286, E(): 1.2e-12, (39.55% identity in 129 aa overlap); Q981I7|MLL9357 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (131 aa), FASTA scores: opt: 257, E(): 1.2e-10, (36.35% identity in 132 aa overlap); Q9AAG1|CC0639 HYPOTHETICAL PROTEIN from Caulobacter crescentus (131 aa), FASTA scores: opt: 217, E(): 6.9e-08, (33.35% identity in 132 aa overlap); etc.; hypothetical protein	complement(3070875..3071270)	Mycobacterium tuberculosis H37Rv	888293
NP_217276.1	CDS	Rv2760c	NC_000962.2	3071267	3071536	R	Rv2760c, (MTV002.25c), len: 89 aa. Conserved hypothetical protein, showing some similarity with two hypothetical proteins from Mycobacterium tuberculosis O07770|Rv0608|MTCY19H5.14c (81 aa), FASTA scores: opt: 128, E(): 0.057, (37.5% identity in 88 aa overlap); and P96913|Rv0623|MTCY20H10.04 (84 aa), FASTA scores: opt: 99, E(): 5.5, (37.1% identity in 89 aa overlap). Also showing some similarity with CAC45377|SMC00899 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (84 aa), FASTA scores: opt: 116, E(): 0.38, (36.25% identity in 91 aa overlap).; hypothetical protein	complement(3071267..3071536)	Mycobacterium tuberculosis H37Rv	887705
NP_217277.1	CDS	hsdS	NC_000962.2	3071546	3072640	R	Rv2761c, (MTV002.26c), len: 364 aa. Possible hsdS, type I restriction/modification system specificity determinant (S protein), similar in part to other hsdS protein (S PROTEINS) e.g. Q9P9X9|XF2741 from Xylella fastidiosa (412 aa), FASTA scores: opt: 252, E(): 7.4e-09, (24.95% identity in 401 aa overlap); N-terminus of Q9RC12 TYPE I S-SUBUNIT from Lactobacillus delbrueckii (subsp. lactis) (389 aa), FASTA scores: opt: 232, E(): 1.4e-07, (28.1% identity in 185 aa overlap); N-terminus of P72419|STY|SBLI from Salmonella typhimurium (434 aa), FASTA scores: opt: 221, E(): 8e-07, (28.45% identity in 130 aa overlap); C-terminus of P17222|PRRB_ECOLI from Escherichia coli strain CTR5X (401 aa), FASTA scores: opt: 197, E(): 2.8e-05, (27.05% identity in 148 aa overlap); etc. SEEMS TO BELONG TO TYPE-I RESTRICTION SYSTEM S METHYLASE FAMILY.; type I restriction/modification system specificity determinant HsdS	complement(3071546..3072640)	Mycobacterium tuberculosis H37Rv	887695
NP_217278.1	CDS	Rv2762c	NC_000962.2	3072637	3073056	R	Rv2762c, (MTV002.27c), len: 139 aa. Conserved hypothetical protein, similar to C-terminus of hypothetical proteins: Q9A380|CC3324 from Caulobacter crescentus (409 aa), FASTA scores: opt: 181, E(): 9.8e-05, (43.55% identity in 101 aa overlap); Q98KQ4|MLR1373 from Rhizobium loti (Mesorhizobium loti) (399 aa), FASTA scores: opt: 174, E(): 0.00028, (46.35% identity in 82 aa overlap); and Q9HZZ9|PA2844 from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: 158, E(): 0.0033, (40.0% identity in 80 aa overlap).; hypothetical protein	complement(3072637..3073056)	Mycobacterium tuberculosis H37Rv	887698
NP_217279.1	CDS	dfrA	NC_000962.2	3073130	3073609	R	Rv2763c, (MTV002.28c), len: 159 aa. Probable dfrA (alternate gene names: folA, dhfr), dihydrofolate reductase (EC 1.5.1.3), equivalent to O30463|FOLA DIHYDROFOLATE REDUCTASE from Mycobacterium avium (see citation below) (181 aa), FASTA scores: opt: 802, E(): 4.5e-48, (70.2% identity in 161 aa overlap); and Q9CBW1|FOLA|ML1518 DIHYDROFOLATE REDUCTASE from Mycobacterium leprae (165 aa), FASTA scores: opt: 782, E(): 1e-46, (70.55% identity in 163 aa overlap). Also highly similar to many e.g. Q9K168|DYR_NEIMB|FOLA|NMB0308 from Neisseria meningitidis (serogroup B) (162 aa), FASTA scores: opt: 469, E(): 3.8e-25, (46.65% identity in 163 aa overlap); P12833|DYR3_SALTY|DHFRIII from Salmonella typhimurium (162 aa), FASTA scores: opt: 367, E(): 4e-18, (45.4% identity in 141 aa overlap); Q59408|DYRC_ECOLI|DHFRXIII from Escherichia coli strain RA33.2 (165 aa), FASTA scores: opt: 313, E(): 2.2e-14, (41.9% identity in 136 aa overlap); etc. Contains PS00075 Dihydrofolate reductase signature. BELONGS TO THE DIHYDROFOLATE REDUCTASE FAMILY.; folA; dihydrofolate reductase DFRA (DHFR) (tetrahydrofolate dehydrogenase)	complement(3073130..3073609)	Mycobacterium tuberculosis H37Rv	887777
NP_217280.1	CDS	thyA	NC_000962.2	3073680	3074471	R	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase	complement(3073680..3074471)	Mycobacterium tuberculosis H37Rv	887728
NP_217281.1	CDS	Rv2765	NC_000962.2	3074636	3075373	D	Rv2765, (MTV002.30), len: 245 aa. Probable ala-rich hydrolase (EC 3.-.-.-), similar to various hydrolases or hypothetical proteins e.g. Q9KYM6|SC9H11.13c PUTATIVE HYDROLASE from Streptomyces coelicolor (251 aa), FASTA scores: opt: 630, E(): 1.4e-33, (43.1% identity in 246 aa overlap); Q9A5T9|CC2358 DIENELACTONE HYDROLASE FAMILY PROTEIN from Caulobacter crescentus (286 aa), FASTA scores: opt: 592, E(): 4.5e-31, (38.45% identity in 242 aa overlap); Q9FCF1|2SCD46.33 PUTATIVE HYDROLASE (DIENELACTONE HYDROLASE FAMILY) from Streptomyces coelicolor (254 aa), FASTA scores: opt: 500, E(): 3.9e-25, (37.7% identity in 252 aa overlap); P73163|DLHH_SYNY3|SLL1298 PUTATIVE CARBOXYMETHYLENEBUTENOLIDASE (DIENELACTONE HYDROLASE) (EC 3.1.1.45) from Synechocystis sp. (strain PCC 6803) (246 aa), FASTA scores: opt: 276, E(): 1.3e-10, (26.95% identity in 230 aa overlap); etc.; hypothetical protein	3074636..3075373	Mycobacterium tuberculosis H37Rv	887714
YP_177905.1	CDS	fabG	NC_000962.2	3075588	3076370	R	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase	complement(3075588..3076370)	Mycobacterium tuberculosis H37Rv	887727
NP_217283.1	CDS	Rv2767c	NC_000962.2	3076367	3076720	R	Rv2767c, (MTV002.32c), len: 117 aa (questionable ORF). Possible membrane protein, showing very weak similarity with Q9L2H7|SCC121.09 PUTATIVE METAL TRANSPORT ABC TRANSPORTER from Streptomyces coelicolor (256 aa), FASTA scores: opt: 110, E(): 1, (33.05% identity in 112 aa overlap).; hypothetical protein	complement(3076367..3076720)	Mycobacterium tuberculosis H37Rv	887762
YP_177906.1	CDS	PPE43	NC_000962.2	3076894	3078078	R	Rv2768c, (MTV002.33c), len: 394 aa. Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. upstream ORF O33312|Rv2770c|MTV002.35c (402 aa), FASTA scores: opt: 1135, E(): 6.1e-51, (62.15% identity in 391 aa overlap); and P96362|Rv1039c|MTCY10G2.10 from M. tuberculosis (391 aa), FASTA scores: opt: 1721, E(): 6.8e-81, (70.35% identity in 398 aa overlap). Equivalent to AAK47157 from Mycobacterium tuberculosis strain CDC1551 (462 aa) but shorter 68 aa.; PPE family protein	complement(3076894..3078078)	Mycobacterium tuberculosis H37Rv	887765
YP_177907.1	CDS	PE27	NC_000962.2	3078158	3078985	R	Rv2769c, (MTV002.34c), len: 275 aa. Member of the Mycobacterium tuberculosis PE family (see citation below), highly similar to many (notably in N-terminal part) e.g. P96361|Rv1040c|MTCY10G2.09 from Mycobacterium tuberculosis (275 aa), FASTA scores: opt: 1111, E(): 5.9e-52, (68.55% identity in 283 aa overlap).; PE family protein	complement(3078158..3078985)	Mycobacterium tuberculosis H37Rv	888461
YP_177677.1	CDS	PPE44	NC_000962.2	3079309	3080457	R	Rv2770c, (MTV002.35c), len: 382 aa. Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. downstream ORF O33310|Rv2768c|MTV002.33c from M. tuberculosis (394 aa), FASTA scores: opt: 1135, E(): 2.2e-53, (62.15% identity in 391 aa overlap); and P96362|Rv1039c|MTCY10G2.10 from Mycobacterium tuberculosis (391 aa), FASTA scores: opt: 1010, E(): 1e-46, (55.95% identity in 395 aa overlap). Equivalent to AAK47159 from Mycobacterium tuberculosis strain CDC1551 (402 aa) but shorter 20 aa. Start changed since first submission (-20 aa).; PPE family protein	complement(3079309..3080457)	Mycobacterium tuberculosis H37Rv	888456
NP_217287.1	CDS	Rv2771c	NC_000962.2	3080581	3081033	R	Rv2771c, (MTV002.36c), len: 150 aa. Conserved hypothetical protein, equivalent to Q9CBV8|ML1525 HYPOTHETICAL PROTEIN from Mycobacterium leprae (151 aa), FASTA scores: opt: 489, E(): 1.7e-27, (52.7% identity in 148 aa overlap). Also highly similar to Q9RD46|SCF56.21 HYPOTHETICAL 15.7 KDA PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 671, E(): 2.2e-40, (67.8% identity in 146 aa overlap).; hypothetical protein	complement(3080581..3081033)	Mycobacterium tuberculosis H37Rv	888434
NP_217288.1	CDS	Rv2772c	NC_000962.2	3081119	3081592	R	Rv2772c, (MTV002.37c), len: 157 aa. Probable conserved transmembrane protein, equivalent to Q9CBV7|ML1526 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (160 aa), FASTA scores: opt: 767, E(): 1.5e-43, (76.6% identity in 154 aa overlap); and similar to P46830|YDAB_MYCBO from Mycobacterium bovis (177 aa), FASTA scores: opt: 337, E(): 3.9e-15, (40.75% identity in 135 aa overlap). Also similar to O86837|SC9A10.04 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 338, E(): 3e-15, (43.75% identity in 144 aa overlap).; transmembrane protein	complement(3081119..3081592)	Mycobacterium tuberculosis H37Rv	888449
NP_217289.1	CDS	dapB	NC_000962.2	3081604	3082341	R	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase	complement(3081604..3082341)	Mycobacterium tuberculosis H37Rv	888443
NP_217290.1	CDS	Rv2774c	NC_000962.2	3082352	3082756	R	Rv2774c, (MTV002.39c), len: 134 aa. Hypothetical unknown protein.; hypothetical protein	complement(3082352..3082756)	Mycobacterium tuberculosis H37Rv	888439
NP_217291.1	CDS	Rv2775	NC_000962.2	3082909	3083370	D	Rv2775, (MTV002.40), len: 153 aa. Hypothetical unknown protein, showing weak similarity with hypothetical proteins e.g. Q9ZBJ7|SC9C7.13c from Streptomyces coelicolor (179 aa), FASTA scores: opt: 167, E(): 0.00024, (29.05% identity in 148 aa overlap). Equivalent to AAK47164 from Mycobacterium tuberculosis strain CDC1551 (185 aa) but shorter 32 aa.; hypothetical protein	3082909..3083370	Mycobacterium tuberculosis H37Rv	888432
NP_217292.1	CDS	Rv2776c	NC_000962.2	3083374	3084303	R	Rv2776c, (MTV002.41c), len: 309 aa. Probable oxidoreductase (EC 1.-.-.-), similar to other oxidoreductases e.g. Q9KZ15|SC10B7.17 PUTATIVE IRON-SULFUR OXIDOREDUCTASE from Streptomyces coelicolor (364 aa), FASTA scores: opt: 846, E(): 1.2e-45, (46.75% identity in 308 aa overlap); O88034|SC5A7.28c IRON-SULFUR OXIDOREDUCTASE BETA SUBUNIT from Streptomyces coelicolor (313 aa), FASTA scores: opt: 745, E(): 2.3e-39, (41.45% identity in 316 aa overlap); P33164|PDR_BURCE|OPHA1 PHTHALATE DIOXYGENASE REDUCTASE from Burkholderia cepacia (Pseudomonas cepacia) (321 aa), FASTA scores: opt: 616, E(): 2.9e-31, (33.65% identity in 309 aa overlap); etc. Equivalent to AAK47165 from Mycobacterium tuberculosis strain CDC1551 (363 aa) but shorter 54 aa. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and PS00063 Aldo/keto reductase family putative active site signature. SEEMS TO BELONG TO THE 2FE2S PLANT-TYPE FERREDOXIN FAMILY IN THE C-TERMINAL SECTION.; oxidoreductase	complement(3083374..3084303)	Mycobacterium tuberculosis H37Rv	888453
NP_217293.1	CDS	Rv2777c	NC_000962.2	3084485	3085555	R	Rv2777c, (MTV002.42c), len: 356 aa. Conserved hypothetical protein, highly similar (but longer in N-terminus) to hypothetical proteins Q9KZ16|SC10B7.16 from Streptomyces coelicolor (296 aa), FASTA scores: opt: 980, E(): 6.8e-57, (51.25% identity in 281 aa overlap); and Q9HYS0|PA3325 from Pseudomonas aeruginosa (295 aa), FASTA scores: opt: 816, E(): 4e-46, (43.75% identity in 288 aa overlap); and similar (but longer in N-terminus) to other hypothetical proteins e.g. Q9I3H1|PA1542 from Pseudomonas aeruginosa (278 aa), FASTA scores: opt: 234, E(): 6.3e-08, (31.8% identity in 258 aa overlap). Equivalent to AAK47166 from Mycobacterium tuberculosis strain CDC1551 (393 aa) but shorter 37 aa.; hypothetical protein	complement(3084485..3085555)	Mycobacterium tuberculosis H37Rv	887833
NP_217294.1	CDS	Rv2778c	NC_000962.2	3085713	3086183	R	Rv2778c, (MTV002.43c), len: 156 aa. Conserved hypothetical protein, similar to Q9CBF7|ML2031 HYPOTHETICAL PROTEIN from Mycobacterium leprae (151 aa), FASTA scores: opt: 227, E(): 8.5e-09, (35.95% identity in 153 aa overlap). Also similar to AAK46204|MT1931.1 HYPOTHETICAL 17.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (158 aa), FASTA scores: opt: 238, E(): 1.5e-09, (35.75% identity in 151 aa overlap); or O07748|Rv1883c|MTCY180.35 HYPOTHETICAL 17.3 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (158 aa), FASTA scores: opt: 212, E(): 9.7e-08, (34.45% identity in 151 aa overlap); note that AAK46204|MT1931.1 and O07748|Rv1883c|MTCY180.35 are essentially the same protein except for a small (5 aa) gap.; hypothetical protein	complement(3085713..3086183)	Mycobacterium tuberculosis H37Rv	887751
NP_217295.2	CDS	Rv2779c	NC_000962.2	3086215	3086754	R	Rv2779c, (MTV002.44c), len: 179 aa. Possible transcriptional regulator, from the Lrp/AsnC family, similar (but longer 30 aa in N-terminus) to others e.g. CAC42842|SCBAC36F5.06 PUTATIVE ASNC-FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (163 aa), FASTA scores: opt: 333, E(): 4.4e-16, (39.7% identity in 141 aa overlap); O07920|AZLB_BACSU TRANSCRIPTIONAL REGULATOR (ASNC FAMILY) from Bacillus subtilis; Q9I233|PA2082 PROBABLE TRANSCRIPTIONAL REGULATOR (ASNC FAMILY) from Pseudomonas aeruginosa (158 aa), FASTA scores: opt: 322, E(): 2.5e-15, (33.1% identity in 148 aa overlap); etc. Also similar to P96896|Rv3291c|MTCY71.31c from Mycobacterium tuberculosis (33.3% identity in 120 aa overlap). Equivalent to AAK47168 from Mycobacterium tuberculosis strain CDC1551 (181 aa). SEEMS TO BELONG TO THE ASNC FAMILY OF TRANSCRIPTIONAL REGULATORS. Start changed since first submission (+8 aa).; LRP/AsnC family transcriptional regulator	complement(3086215..3086754)	Mycobacterium tuberculosis H37Rv	888479
NP_217296.1	CDS	ald	NC_000962.2	3086820	3087935	D	Rv2780, (MT2850, MTV002.45), len: 371 aa. ald, secreted L-alanine dehydrogenase (EC 1.4.1.1) (40 kd antigen); equivalent to Q9CBV6|ALD|ML1532 L-ALANINE DEHYDROGENASE from Mycobacterium leprae (371 aa), FASTA scores: opt: 2081, E(): 4e-115, (85.45% identity in 371 aa overlap). Also highly similar to others e.g. Q9S227|SCI51.13c from Streptomyces coelicolor (371 aa), FASTA scores: opt: 1575, E(): 2.3e-85, (66.05% identity in 371 aa overlap); Q9K827|BH3180 from Bacillus halodurans (371 aa), FASTA scores: opt: 1341, E(): 1.4e-71, (56.45% identity in 372 aa overlap); Q9RT70|DR1895 from Deinococcus radiodurans (390 aa), FASTA scores: opt: 1319, E(): 2.8e-70, (54.2% identity in 371 aa overlap); etc. Contains PS00836 and PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1 and 2.; secreted L-alanine dehydrogenase ALD (40 kDa antigen) (TB43)	3086820..3087935	Mycobacterium tuberculosis H37Rv	888493
NP_217297.1	CDS	Rv2781c	NC_000962.2	3087950	3088984	R	Rv2781c, (MTV002.46c), len: 344 aa. Possible ala-rich oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases or hypothetical proteins e.g. Q9RDD8|SCC77.20c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (364 aa), FASTA scores: opt: 912, E(): 5.3e-47, (45.55% identity in 336 aa overlap); Q9FDD4|2-NPDL PUTATIVE 2-NITROPROPANE DIOXYGENASE from Streptomyces ansochromogenes (363 aa), FASTA scores: opt: 869, E(): 1.9e-44, (44.2% identity in 337 aa overlap); O05413|YRPB 2-NITROPROPANE DIOXYGENASE from Bacillus subtilis (347 aa), FASTA scores: opt: 560, E(): 4.9e-26, (33.75% identity in 317 aa overlap); etc.; alanine rich oxidoreductase	complement(3087950..3088984)	Mycobacterium tuberculosis H37Rv	888488
NP_217298.1	CDS	pepR	NC_000962.2	3089045	3090361	R	deleted EC_number 3.4.99.-; Rv2782c, (MTV002.47c), len: 438 aa. Probable pepR, protease/peptidase (EC 3.4.99.-), equivalent to O32965|YR82_MYCLE|ML0855|MLCB22.26c HYPOTHETICAL ZINC PROTEASE from Mycobacterium leprae (445 aa), FASTA scores: opt: 2346, E(): 4.3e-146, (84.3% identity in 421 aa overlap). Also highly similar to others e.g. O86835|YA12_STRCO|SC9A10.02 from Streptomyces coelicolor (459 aa), FASTA scores: opt: 1394, E(): 1.1e-83, (51.9% identity in 416 aa overlap); Q04805|YMXG_BACSU|YMXG from Bacillus subtilis (409 aa), FASTA scores: opt: 1014, E(): 7.9e-59, (37.55% identity in 410 aa overlap); Q9KA85|BH2405 from Bacillus halodurans (413 aa), FASTA scores: opt: 967, E(): 9.6e-56, (38.6% identity in 417 aa overlap); etc. Contains PS00143 Insulinase family, zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY M16, ALSO KNOWN AS THE INSULINASE FAMILY. COFACTOR: REQUIRES DIVALENT CATIONS FOR ACTIVITY. BINDS ZINC.; zinc protease PEPR	complement(3089045..3090361)	Mycobacterium tuberculosis H37Rv	888470
NP_217299.1	CDS	gpsI	NC_000962.2	3090339	3092597	R	Rv2783c, (MTV002.48c), len: 752 aa. Probable gpsI, polyribonucleotide nucleotidyltransferase (EC 2.7.7.8; 2.7.6.-), equivalent to Q9CCF8|GPSI|ML0854 (alias O32966) PUTATIVE POLYRIBONUCLEOTIDE PHOSPHORYLASE / GUANOSINE PENTAPHOSPHATE SYNTHETASE from Mycobacterium leprae (773 aa), FASTA scores: opt: 4304, E(): 0, (89.95% identity in 757 aa overlap). Also highly similar to others e.g. O86656|GPSI GUANOSINE PENTAPHOSPHATE SYNTHETASE/ POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (FRAGMENT) from Streptomyces coelicolor (716 aa), FASTA scores: opt: 3393, E(): 5.8e-192, (72.77% identity in 718 aa overlap); Q53597|GPSI GUANOSINE PENTAPHOSPHATE SYNTHETASE from Streptomyces antibioticus (740 aa), FASTA scores: opt: 3314, E(): 2.6e-187, (70.55% identity in 733 aa overlap); P72659|PNP|SLL1043 POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE from Synechocystis sp. strain PCC 6803 (718 aa), FASTA scores: opt: 1244, E(): 1.7e-65, (45.05% identity in 750 aa overlap); etc. Note that S. antibioticus guanosine pentaphosphate synthetase is a multifunctional enzyme that also acts as a polyribonucleotide nucleotidyltransferase. Start site chosen by homology from several alternatives.; polynucleotide phosphorylase/polyadenylase	complement(3090339..3092597)	Mycobacterium tuberculosis H37Rv	888467
NP_217300.1	CDS	lppU	NC_000962.2	3092951	3093466	R	Rv2784c, (MTV002.49c), len: 171 aa. Probable lppU, lipoprotein, sharing no homology with other proteins. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LppU	complement(3092951..3093466)	Mycobacterium tuberculosis H37Rv	888484
NP_217301.1	CDS	rpsO	NC_000962.2	3093479	3093748	R	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15	complement(3093479..3093748)	Mycobacterium tuberculosis H37Rv	888455
NP_217302.1	CDS	ribF	NC_000962.2	3093905	3094900	R	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase	complement(3093905..3094900)	Mycobacterium tuberculosis H37Rv	888468
NP_217303.1	CDS	Rv2787	NC_000962.2	3095111	3096874	D	Rv2787, (MTV002.52), len: 587 aa. Conserved hypothetical ala-rich protein, equivalent to Q9CCI1|ML0798 HYPOTHETICAL PROTEIN from Mycobacterium leprae (592 aa), FASTA scores: opt: 2994, E(): 6.9e-179, (76.5% identity in 587 aa overlap); and similar in part to other proteins from Mycobacterium leprae e.g. O33082|MLCB628.11 HYPOTHETICAL 52.0 KDA PROTEIN (478 aa), FASTA scores: opt: 481, E(): 2.3e-22, (30.95% identity in 294 aa overlap). Also similar in part to O86637|SC3C3.03c HYPOTHETICAL 112.1 KDA PROTEIN from Streptomyces coelicolor (1083 aa), FASTA scores: opt: 488, E(): 1.5e-22, (28.95% identity in 297 aa overlap). And similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. O06396|Rv0530|MTCY25D10.09 (405 aa), FASTA scores: opt: 625, E(): 2.2e-31, (34.05% identity in 320 aa overlap); O69740|Rv3876|MTV027.11 (666 aa), FASTA scores: opt: 453, E(): 1.6e-20, (29.2% identity in 370 aa overlap); P96217|Rv3860|MTCY01A6.08c (390 aa), FASTA scores: opt: 443, E(): 4.7e-20, (29.95% identity in 354 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	3095111..3096874	Mycobacterium tuberculosis H37Rv	888288
NP_217304.1	CDS	sirR	NC_000962.2	3096959	3097645	D	Rv2788, (MTV002.53), len: 228 aa. Probable sirR, transcriptional repressor, highly similar to others e.g. Q9RRF3|DR2539 PUTATIVE IRON DEPENDENT REPRESSOR from Deinococcus radiodurans (232 aa), FASTA scores: opt: 518, E(): 4.5e-26, (41.2% identity in 221 aa overlap); Q9HRU8|SIRR|VNG0536G from Halobacterium sp. strain NRC-1 (233 aa), FASTA scores: opt: 516, E(): 6.1e-26, (40.45% identity in 220 aa overlap); Q9KIJ2|SLOR REGULATOR SLOR from Streptococcus mutans (217 aa), FASTA scores: opt: 418, E(): 1.2e-19, (36.15% identity in 213 aa overlap); etc. Also some similarity to Q50495|IDER_MYCTU|MTCY05A6.32|IDER|DTXR|Rv2711|MT2784|MTC Y0 5A6.32 IRON-DEPENDENT REPRESSOR from Mycobacterium tuberculosis (230 aa), FASTA scores: opt: 266, E(): 7.1e-10, (27.6% identity in 221 aa overlap). Contains helix-turn-helix motif at aa 32-53 (Score 1327, +3.71 SD). COULD BELONG TO THE CRP/FNR FAMILY OF TRANSCRIPTIONAL REGULATORS.; transcriptional repressor SIRR	3096959..3097645	Mycobacterium tuberculosis H37Rv	888253
NP_217305.1	CDS	fadE21	NC_000962.2	3097706	3098938	R	Rv2789c, (MTV002.54c), len: 410 aa. Probable fadE21, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 689, E(): 9.3e-37, (35.75% identity in 400 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 679, E(): 4.1e-36, (37.3% identity in 405 aa overlap); Q06319|ACDS_MEGEL from Megasphaera elsdenii (383 aa), FASTA scores: opt: 650, E(): 3e-34, (37.7% identity in 334 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 1 (PS00072). BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE21	complement(3097706..3098938)	Mycobacterium tuberculosis H37Rv	888258
NP_217306.1	CDS	ltp1	NC_000962.2	3098964	3100169	R	Rv2790c, (MTV002.55c), len: 401 aa. Probable ltp1, lipid-transfer protein, highly similar to many eukaryotic sterol-carrier proteins/lipid-transfer protein precursors (see Ossendorp & Wirtz 1993) e.g. O62742|SCP2 STEROL CARRIER PROTEIN X from Oryctolagus cuniculus (Rabbit) (547 aa), FASTA scores: opt: 1710, E(): 6e-102, (63.7% identity in 394 aa overlap); Q9QW19 3-OXOACYL-CoA THIOLASE HOMOLOG (FRAGMENT) from Rattus sp. (405 aa), FASTA scores: opt: 1696, E(): 3.8e-101, (63.2% identity in 394 aa overlap); P11915|NLTP_RAT|SCP2|SCP-2 NONSPECIFIC LIPID-TRANSFER PROTEIN PRECURSOR from Rattus norvegicus (Rat) (547 aa), FASTA scores: opt: 1696, E(): 4.8e-101, (63.2% identity in 394 aa overlap); P32020|NLTP_MOUSE|SCP2|SCP-2 NONSPECIFIC LIPID-TRANSFER PROTEIN PRECURSOR from Mus musculus (Mouse) (547 aa), FASTA scores: opt: 1681, E(): 4.3e-100, (62.7% identity in 394 aa overlap); etc. Contains PS00098 Thiolases acyl-enzyme intermediate signature and PS00737 Thiolases signature 2. Also similar to other M. tuberculosis proteins e.g. O06144|Rv1627c|MTCY01B2.19c (402 aa) (35.8% identity in 413 aa overlap).; lipid-transfer protein	complement(3098964..3100169)	Mycobacterium tuberculosis H37Rv	888585
NP_217307.1	CDS	Rv2791c	NC_000962.2	3100202	3101581	R	Rv2791c, (MTV002.56c), len: 459 aa. Probable IS1602 transposase for IS1602 element, similar to many e.g. P95117|Rv2978c|MTCY349.09 from Mycobacterium tuberculosis (459 aa), FASTA scores: opt: 2718, E(): 6.3e-165, (86.05% identity in 459 aa overlap).; transposase	complement(3100202..3101581)	Mycobacterium tuberculosis H37Rv	888281
NP_217308.1	CDS	Rv2792c	NC_000962.2	3101581	3102162	R	Rv2792c, (MTV002.57c), len: 193 aa. Possible IS1602 resolvase, highly similar to many from Mycobacterium tuberculosis e.g. O07773|Rv0605|MTCY19H5.17c POSSIBLE RESOLVASE (202 aa), FASTA scores: opt: 1040, E(): 1.9e-62, (85.05% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site and possible helix-turn-helix motif at aa 1-2 (Score 1687, +4.93 SD).; resolvase	complement(3101581..3102162)	Mycobacterium tuberculosis H37Rv	888274
NP_217309.1	CDS	truB	NC_000962.2	3102364	3103260	R	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B	complement(3102364..3103260)	Mycobacterium tuberculosis H37Rv	888587
NP_217310.1	CDS	Rv2794c	NC_000962.2	3103257	3103940	R	Rv2794c, (MTV002.59c), len: 227 aa. Conserved hypothetical protein, equivalent to Q9Z5I5|ML1547|MLCB596.23 PUTATIVE IRON-CHELATING COMPLEX SUBUNIT from Mycobacterium leprae (227 aa), FASTA scores: opt: 1248, E(): 9.1e-77, (79.75% identity in 227 aa overlap). Also highly similar to various proteins e.g. Q9F0Q6|PPTA PHOSPHOPANTETHEINYL TRANSFERASE from Streptomyces verticillus (246 aa), FASTA scores: opt: 692, E(): 2.8e-39, (46.65% identity in 225 aa overlap); O88029|SC5A7.23 HYPOTHETICAL 24.5 KDA PROTEIN from Streptomyces coelicolor (226 aa), FASTA scores: opt: 679, E(): 2e-38, (46.9% identity in 226 aa overlap); O24813 DNA FOR L-PROLINE 3-HYDROXYLASE from Streptomyces sp. (208 aa), FASTA scores: opt: 631, E(): 3.2e-35, (48.1% identity in 208 aa overlap); etc.; hypothetical protein	complement(3103257..3103940)	Mycobacterium tuberculosis H37Rv	888226
NP_217311.1	CDS	Rv2795c	NC_000962.2	3103937	3104911	R	Rv2795c, (MTV002.60c), len: 324 aa. Conserved hypothetical protein, equivalent to Q9Z5I6|ML1548|MLCB596.22 HYPOTHETICAL 37.5 KDA PROTEIN from Mycobacterium leprae (321 aa), FASTA scores: opt: 2018, E(): 6.3e-128, (87.4% identity in 318 aa overlap). Also highly similar to O88028|SC5A7.22 HYPOTHETICAL 33.5 KDA PROTEIN from Streptomyces coelicolor (295 aa), FASTA scores: opt: 1202, E(): 3.4e-73, (57.2% identity in 285 aa overlap); and Q9AMH7|SIMX4 SIMX4 PROTEIN from Streptomyces antibioticus (293 aa), FASTA scores: opt: 1045, E(): 1.2e-62, (51.4% identity in 286 aa overlap). C-terminus highly similar to Q9F0Q7 HYPOTHETICAL 9.6 KDA PROTEIN (FRAGMENT) from Streptomyces verticillus (81 aa), FASTA scores: opt: 395, E(): 1.8e-19, (68.35% identity in 79 aa overlap). Also similar to other proteins e.g. Q9FWV7 HYPOTHETICAL 45.3 KDA PROTEIN from Oryza sativa (Rice) (402 aa), FASTA scores: opt: 294, E(): 3.6e-12, (26.45% identity in 340 aa overlap).; hypothetical protein	complement(3103937..3104911)	Mycobacterium tuberculosis H37Rv	888492
NP_217312.1	CDS	lppV	NC_000962.2	3105056	3105619	R	Rv2796c, (MTV002.61c, MTCY16B7.47), len 187 aa. Probable lppV, conserved lipoprotein, similar to others from Mycobacterium tuberculosis e.g. P95009|LPPB|Rv2544|MTCY159.12c PROBABLE CONSERVED LIPOPROTEIN (220 aa), FASTA scores: opt: 168, E(): 0.00066, (22.45% identity in 196 aa overlap); and P95010|LPPA|RV2543|MTCY159.13c PROBABLE CONSERVED LIPOPROTEIN (219 aa), FASTA scores: opt: 165, E(): 0.001, (23.1% identity in 199 aa overlap).; lipoprotein LppV	complement(3105056..3105619)	Mycobacterium tuberculosis H37Rv	888915
NP_217313.1	CDS	Rv2797c	NC_000962.2	3105619	3107307	R	Rv2797c, (MTCY16B7.46), len: 562 aa. Conserved hypothetical ala-rich protein. C-terminus highly similar to several mycobacterial proteins e.g. AAK46927|MT2616 HYPOTHETICAL 28.0 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (265 aa), FASTA scores: opt: 535, E(): 4.6e-22, (42.95% identity in 263 aa overlap); P95011|Rv2542|MTCY159.14c HYPOTHETICAL 42.4 KDA PROTEIN from Mycobacterium tuberculosis (403 aa), FASTA scores: opt: 537, E(): 5e-22, (40.75% identity in 292 aa overlap) (similarity in the second half of protein); P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 HYPOTHETICAL 28.1 KDA PROTEIN (266 aa), FASTA scores: opt: 314, E(): 5.7e-10, (39.0% identity in 254 aa overlap); etc. Contains PS00120 Lipases, serine active site.; hypothetical protein	complement(3105619..3107307)	Mycobacterium tuberculosis H37Rv	887713
NP_217314.1	CDS	Rv2798c	NC_000962.2	3107311	3107637	R	Rv2798c, (MTCY16B7.45), len: 108 aa. Conserved hypothetical ala-rich protein, similar to P71545|Y965_MYCTU|Rv0965c|MT0993|MTCY10D7.09 HYPOTHETICAL 14.5 KDA PROTEIN from Mycobacterium tuberculosis (139 aa), FASTA scores: opt: 198, E(): 8e-07, (38.9% identity in 90 aa overlap).; hypothetical protein	complement(3107311..3107637)	Mycobacterium tuberculosis H37Rv	888431
NP_217315.1	CDS	Rv2799	NC_000962.2	3107768	3108397	D	Rv2799, (MTCY16B7.44c), len: 209 aa. Probable membrane protein.; hypothetical protein	3107768..3108397	Mycobacterium tuberculosis H37Rv	887759
NP_217316.1	CDS	Rv2800	NC_000962.2	3108416	3110065	D	Rv2800, (MTCY16B7.43c), len: 549 aa. Possible hydrolase (EC 3.-.-.-), an esterase (EC 3.1.1.-) or an acylase (EC 3.-.-.-). Similar, but longer in N-terminus, to esterases or acylases e.g. Q9L9D7|COCE COCAINE ESTERASE from Rhodococcus sp. MB1 'Bresler 1999' (574 aa), FASTA scores: opt: 510, E(): 3.1e-23, (33.6% identity in 571 aa overlap); Q9L3U2|STTE PUTATIVE ACYLASE from Streptomyces rochei (Streptomyces parvullus) (554 aa), FASTA scores: opt: 492, E(): 3.7e-22, (34.45% identity in 569 aa overlap); CAC49652|SMB21424 PUTATIVE ESTERASE OR ACYLASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (578 aa), FASTA scores: opt: 405, E(): 7.1e-17, (34.45% identity in 569 aa overlap); etc.; hydrolase	3108416..3110065	Mycobacterium tuberculosis H37Rv	888932
NP_217317.1	CDS	Rv2801c	NC_000962.2	3110167	3110523	R	Rv2801c, (MTCY16B7.42), len: 118 aa. Conserved hypothetical protein, highly similar to Q9RWK4|DR0662 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (115 aa), FASTA scores: opt: 306, E(): 2e-15, (43.95% identity in 116 aa overlap); and similar to AAK78474|CAC0494 PEMK FAMILY OF DNA-BINDING PROTEINS from Clostridium acetobutylicum (122 aa), FASTA scores: opt: 217, E(): 7.3e-09, (33.35% identity in 117 aa overlap); P96622|YDCE YDCE PROTEIN from Bacillus subtilis (116 aa), FASTA scores: opt: 194, E(): 3.5e-07, (33.35% identity in 117 aa overlap); Q9PHH8|XFA0027 PLASMID MAINTENANCE PROTEIN from Xylella fastidiosa (108 aa), FASTA scores: opt: 188, E(): 9.1e-07, (40.85% identity in 115 aa overlap); etc. Also similar to Q10867|YJ91_MYCTU|Rv1991c|MT2046|MTCY39.28 HYPOTHETICAL 12.3 KDA PROTEIN from Mycobacterium tuberculosis (114 aa), FASTA scores: opt: 190, E(): 6.8e-07, (36.75% identity in 117 aa overlap).; hypothetical protein	complement(3110167..3110523)	Mycobacterium tuberculosis H37Rv	888921
NP_217318.1	CDS	Rv2802c	NC_000962.2	3110780	3111823	R	Rv2802c, (MTCY16B7.41), len: 347 aa. Hypothetical unknown arg-, ala-rich protein. C-terminus shows some similarity with N-terminal part of hypothetical proteins Q98K84|MLR1592 from Rhizobium loti (Mesorhizobium loti) (104 aa), FASTA scores: opt: 138, E(): 0.12, (37.35% identity in 91 aa overlap); and CAC47718|SMC03294 from Rhizobium meliloti (Sinorhizobium meliloti) (114 aa), FASTA scores: opt: 128, E(): 0.53, (31.4% identity in 86 aa overlap). Equivalent to AAK47191 from Mycobacterium tuberculosis strain CDC1551 (357 aa) but shorter 10 aa.; hypothetical protein	complement(3110780..3111823)	Mycobacterium tuberculosis H37Rv	888931
YP_177678.1	CDS	Rv2803	NC_000962.2	3111822	3112289	D	Rv2803, len: 155 aa. Conserved hypothetical protein, similar to hypothetical proteins from other organisms, and with some similarity to C-terminal part of Rv0918|Z95210_12 hypothetical protein from Mycobacterium tuberculosis (158 aa), FASTA scores: opt: 204, E(): 9e-07, (42.35% identity in 85 aa overlap). Replaces original 2803c on other strand.; hypothetical protein	3111822..3112289	Mycobacterium tuberculosis H37Rv	888416
NP_217320.1	CDS	Rv2804c	NC_000962.2	3112465	3113094	R	Rv2804c, (MTCY16B7.39), len: 209 aa. Hypothetical unknown protein, overlaps neighbouring orf Rv2805|MTCY16B7.38c.; hypothetical protein	complement(3112465..3113094)	Mycobacterium tuberculosis H37Rv	888418
NP_217321.1	CDS	Rv2805	NC_000962.2	3112867	3113271	D	Rv2805, (MTCY16B7.38c), len: 134 aa. Conserved hypothetical protein, highly similar to N-terminal region of downstream ORF P71644|Rv2807|MTCY16B7.36c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 525, E(): 6.4e-29, (78.2% identity in 101 aa overlap). Also highly similar to N-terminus of other proteins: Q9KK74 HYPOTHETICAL 47.4 KDA PROTEIN from Brevibacterium linens (418 aa), FASTA scores: opt: 480, E(): 8.8e-26, (64.15% identity in 106 aa overlap); AAK40065 Rv3128c-LIKE PROTEIN from Mycobacterium celatum (423 aa), FASTA scores: opt: 218, E(): 1.2e-07, (46.05% identity in 89 aa overlap); Q981U5|MLR9230 from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 131, E(): 0.15, (29.4% identity in 126 aa overlap). Overlaps neighbouring ORF Rv2804c|MTCY16B7.39.; hypothetical protein	3112867..3113271	Mycobacterium tuberculosis H37Rv	888916
NP_217322.1	CDS	Rv2806	NC_000962.2	3113268	3113459	D	Rv2806, (MTCY16B7.37c), len: 63 aa. Possible membrane protein, sharing no homology.; hypothetical protein	3113268..3113459	Mycobacterium tuberculosis H37Rv	888905
NP_217323.1	CDS	Rv2807	NC_000962.2	3113658	3114812	D	Rv2807, (MTCY16B7.36c), len: 384 aa. Conserved hypothetical protein, highly similar, but shorter 35 aa, to Q9KK74 HYPOTHETICAL 47.4 KDA PROTEIN from Brevibacterium linens (418 aa), FASTA scores: opt: 1865, E(): 9.4e-116, (69.75% identity in 380 aa overlap); and with similarity with other hypothetical proteins or transposases e.g. Q981U5|MLR9230 PROTEIN from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 636,, (36.05% identity in 377 aa overlap); CAC47689 PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ISRM18 from Rhizobium meliloti (Sinorhizobium meliloti) (507 aa), FASTA scores: opt: 553, E(): 6.6e-29, (33.5% identity in 370 aa overlap); etc. Also similar to Rv3128c|MTCY164.38c (336 aa) (47.2% identity in 339 aa overlap); and high similarity at N-terminal region with Rv2805|MTCY16B7.38c (79.2% identity in 101 aa overlap).; hypothetical protein	3113658..3114812	Mycobacterium tuberculosis H37Rv	888907
NP_217324.1	CDS	Rv2808	NC_000962.2	3115046	3115303	D	Rv2808, (MTCY16B7.35c), len: 85 aa. Hypothetical unknown protein.; hypothetical protein	3115046..3115303	Mycobacterium tuberculosis H37Rv	888944
NP_217325.1	CDS	Rv2809	NC_000962.2	3115408	3115719	D	Rv2809, (MTCY16B7.34c), len: 103 aa (questionable ORF). Hypothetical unknown protein.; hypothetical protein	3115408..3115719	Mycobacterium tuberculosis H37Rv	888909
NP_217326.1	CDS	Rv2810c	NC_000962.2	3115741	>3116142	R	Rv2810c, (MTCY16B7.33), len: 133 aa. Probable transposase for IS1555, similar to C-terminal domain of transposases for defective IS1555 e.g. Q9LCS0|TNPA TRANSPOSASE from Arthrobacter sp. TM1 (435 aa), FASTA scores: opt: 294, E(): 1.8e-13, (55.1% identity in 98 aa overlap); Q50440|TNPA INSERTION ELEMENT TNPR AND TNPA GENE from Mycobacterium smegmatis (413 aa), FASTA scores: opt: 274, E(): 4.7e-12, (56.25% identity in 96 aa overlap); etc.; transposase	complement(3115741..>3116142)	Mycobacterium tuberculosis H37Rv	887784
NP_217327.1	CDS	Rv2811	NC_000962.2	3116139	3116747	D	Rv2811, (MTCY16B7.32c), len: 202 aa. Conserved hypothetical protein. C-terminus equivalent to C-terminus of AAK47198|MT2878 HYPOTHETICAL 17.7 KDA PROTEIN Mycobacterium tuberculosis strain CDC1551 (178 aa), FASTA scores: opt: 609, E(): 1.5e-32, (61.0% identity in 182 aa overlap); and C-terminus highly similar to P72038|Rv3771c|MTCY13D12.05c HYPOTHETICAL 11.3 KDA PROTEIN from Mycobacterium tuberculosis (108 aa), FASTA scores: opt: 465, E(): 2.8e-23, (73.6% identity in 106 aa overlap). Also some similarity with P71962|Rv2665|MTCY441.34 HYPOTHETICAL 10.5 KDA PROTEIN from Mycobacterium tuberculosis (93 aa), FASTA scores: opt: 153, E(): 0.0057, (39.05% identity in 64 aa overlap); and Q9A6W6|CC1966 HYPOTHETICAL PROTEIN CC1966 from Caulobacter crescentus (189 aa), FASTA scores: opt: 115, E(): 2.6, (39.4% identity in 104 aa overlap).; hypothetical protein	3116139..3116747	Mycobacterium tuberculosis H37Rv	887740
NP_217328.1	CDS	Rv2812	NC_000962.2	3116818	3118227	D	Rv2812, (MTCY16B7.31c), len: 469 aa. Probable transposase for IS1604, similar to putative transposases and hypothetical proteins e.g. Q9EZM2|PUTATIVE TRANSPOSASE from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 329, E(): 3e-13, (27.05% identity in 362 aa overlap); CAC46499 PUTATIVE TRANSPOSASE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (390 aa), FASTA scores: opt: 327, E(): 3.9e-13, (30.5% identity in 367 aa overlap); etc. Contains possible helix-turn-helix motif at aa 50-71 (Score 1140, +3.07 SD).; transposase	3116818..3118227	Mycobacterium tuberculosis H37Rv	888942
NP_217329.1	CDS	Rv2813	NC_000962.2	3118224	3119036	D	Rv2813, (MTCY16B7.30c), len: 270 aa. Conserved hypothetical protein, similar to various proteins (notably secreted proteins) e.g. Q9ZFL2 HYPOTHETICAL 30.4 KDA PROTEIN from Bacillus stearothermophilus (266 aa), FASTA scores: opt: 518, E(): 1.4e-26, (33.85% identity in 266 aa overlap); P45754|GSPA_AERHY|EXEA GENERAL SECRETION PATHWAY PROTEIN from Aeromonas hydrophila (547 aa), FASTA scores: opt: 386, E(): 1.1e-17, (32.05% identity in 265 aa overlap); Q9KPC7|VC2445 GENERAL SECRETION PATHWAY PROTEIN A from Vibrio cholerae (529 aa), FASTA scores: opt: 366, E(): 2.2e-16, (31.1% identity in 270 aa overlap); Q56674|VC0403 MANNOSE-SENSITIVE HEMAGGLUTININ D from Vibrio cholerae (281 aa), FASTA scores: opt: 317, E(): 2.1e-13, (27.85% identity in 262 aa overlap); etc. Also highly similar to AAK40072 Rv2813-LIKE PROTEIN from Mycobacterium celatum (270 aa), FASTA scores: opt: 1628, E(): 2.8e-99, (90.75% identity in 270 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	3118224..3119036	Mycobacterium tuberculosis H37Rv	888570
NP_217330.1	CDS	Rv2814c	NC_000962.2	3120566	>3121504	R	Rv2814c, (MTCY16B7.29), len: 312 aa. Probable transposase, highly similar to others e.g. P97137|Rv0796|MTV042.06 PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS986/IS6110 from Mycobacterium tuberculosis (328 aa), FASTA scores: opt: 2103, E(): 6.1e-132, (100.0% identity in 312 aa overlap); etc. Start unlikely.; transposase	complement(3120566..>3121504)	Mycobacterium tuberculosis H37Rv	887839
NP_217331.1	CDS	Rv2815c	NC_000962.2	3121501	3121827	R	Rv2815c, (MTCY16B7.28), len: 108 aa. Probable transposase, identical from aa 51 with P19772|YIA2_MYCTU PUTATIVE TRANSPOSASE (INSERTION ELEMENT IS986) from Mycobacterium tuberculosis (59 aa), FASTA scores: opt: 365, E(): 1.1e-19, (96.6% identity in 59 aa overlap); and other transposases.; transposase	complement(3121501..3121827)	Mycobacterium tuberculosis H37Rv	888511
NP_217332.1	CDS	Rv2816c	NC_000962.2	3123625	3123966	R	Rv2816c, (MTCY16B7.27), len: 113 aa. Conserved hypothetical protein, highly similar in part to N-terminus of several proteins e.g. O28403|AF1876 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (94 aa), FASTA scores: opt: 137, E(): 0.0022, (47.55% identity in 61 aa overlap); Q97Y85|SSO8090 HYPOTHETICAL PROTEIN from Sulfolobus solfataricus (88 aa), FASTA scores: opt: 124, E(): 0.02, (37.3% identity in 59 aa overlap); etc.; hypothetical protein	complement(3123625..3123966)	Mycobacterium tuberculosis H37Rv	888520
NP_217333.1	CDS	Rv2817c	NC_000962.2	3123967	3124983	R	Rv2817c, (MTCY16B7.26), len: 338 aa. Conserved hypothetical protein, showing similarity with O30236|AF2435 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (322 aa), FASTA scores: opt: 397, E(): 2.4e-19, (28.2% identity in 298 aa overlap); Q9KFX9|BH0341 HYPOTHETICAL PROTEIN from Bacillus halodurans (343 aa), FASTA scores: opt: 337, E(): 2.8e-15, (27.35% identity in 300 aa overlap); Q9X2B7|TM1797 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (319 aa), FASTA scores: opt: 321, E(): 3.3e-14, (26.5% identity in 268 aa overlap); etc.; hypothetical protein	complement(3123967..3124983)	Mycobacterium tuberculosis H37Rv	888506
NP_217334.1	CDS	Rv2818c	NC_000962.2	3124996	3126144	R	Rv2818c, (MTCY16B7.25), len: 382 aa. Hypothetical unknown protein, equivalent to AAK47210 from Mycobacterium tuberculosis strain CDC1551 (430 aa) but shorter 48 aa.; hypothetical protein	complement(3124996..3126144)	Mycobacterium tuberculosis H37Rv	888510
NP_217335.1	CDS	Rv2819c	NC_000962.2	3126240	3127367	R	Rv2819c, (MTCY16B7.23), len: 375 aa. Hypothetical unknown protein (see citations below).; hypothetical protein	complement(3126240..3127367)	Mycobacterium tuberculosis H37Rv	888514
NP_217336.1	CDS	Rv2820c	NC_000962.2	3127364	3128272	R	Rv2820c, (MTCY16B7.22), len: 302 aa. Hypothetical unknown protein.; hypothetical protein	complement(3127364..3128272)	Mycobacterium tuberculosis H37Rv	888908
NP_217337.1	CDS	Rv2821c	NC_000962.2	3128253	3128963	R	Rv2821c, (MTCY16B7.21), len: 236 aa. Conserved hypothetical protein, similar to several hypothetical proteins e.g. Q9X2C9|TM1809 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (247 aa), FASTA scores: opt: 318, E(): 8.2e-15, (39.45% identity in 213 aa overlap); O27152|MTH1080 CONSERVED HYPOTHETICAL PROTEIN from Methanothermobacter thermautotrophicus (245 aa), FASTA scores: opt: 294, E(): 3.9e-13, (34.8% identity in 224 aa overlap); BAB59251|TVG0114661 HYPOTHETICAL PROTEIN from Thermoplasma volcanium (229 aa), FASTA scores: opt: 252, E(): 3.3e-10, (33.8% identity in 225 aa overlap); etc.; hypothetical protein	complement(3128253..3128963)	Mycobacterium tuberculosis H37Rv	887741
NP_217338.1	CDS	Rv2822c	NC_000962.2	3128973	3129347	R	Rv2822c, (MTCY16B7.20), len: 124 aa. Hypothetical unknown protein.; hypothetical protein	complement(3128973..3129347)	Mycobacterium tuberculosis H37Rv	887778
NP_217339.1	CDS	Rv2823c	NC_000962.2	3129344	3131773	R	Rv2823c, (MTCY16B7.19), len: 809 aa. Conserved hypothetical protein, similar in part to others e.g. Q9X2D1|TM1811Thermotoga maritima (717 aa), FASTA scores: opt: 401, E(): 3.6e-18, (27.15% identity in 773 aa overlap); O27154|MTH1082 CONSERVED HYPOTHETICAL PROTEIN from Methanothermobacter thermautotrophicus (822 aa), FASTA scores: opt: 306, E(): 6e-12, (25.55% identity in 872 aa overlap); Q59066|MJ1672 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (800 aa), FASTA scores: opt: 302, E(): 1.1e-11, (24.9% identity in 812 aa overlap); etc.; hypothetical protein	complement(3129344..3131773)	Mycobacterium tuberculosis H37Rv	887735
NP_217340.1	CDS	Rv2824c	NC_000962.2	3131770	3132714	R	Rv2824c, (MTCY16B7.18), len: 314 aa. Hypothetical unknown protein.; hypothetical protein	complement(3131770..3132714)	Mycobacterium tuberculosis H37Rv	888945
NP_217341.1	CDS	Rv2825c	NC_000962.2	3132892	3133539	R	Rv2825c, (MTCY16B7.17), len: 215 aa. Conserved hypothetical protein, similar to Q9RY53|DR0097 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (189 aa), FASTA scores: opt: 261, E(): 8e-11, (33.5% identity in 176 aa overlap); and shows some similarity with N-terminus of O27278|MTH1210 MRR RESTRICTION SYSTEM RELATED PROTEIN from Methanothermobacter thermautotrophicus (340 aa), FASTA scores: opt: 133, E(): 0.091, (28.55% identity in 112 aa overlap). Equivalent to AAK47217 from Mycobacterium tuberculosis strain CDC1551 (246 aa) but shorter 31 aa; and equivalent to upstream ORF P71624|Rv2828c|MTCY16B7.14 from Mycobacterium tuberculosis strain H37Rv (alias AAK47221 from strain CDC1551) (181 aa), FASTA scores: opt: 1169, E(): 8.5e-74, (98.35% identity in 181 aa overlap).; hypothetical protein	complement(3132892..3133539)	Mycobacterium tuberculosis H37Rv	887769
NP_217342.1	CDS	Rv2826c	NC_000962.2	3133709	3134593	R	Rv2826c, (MTCY16B7.16), len: 294 aa. Hypothetical unknown protein.; hypothetical protein	complement(3133709..3134593)	Mycobacterium tuberculosis H37Rv	887742
NP_217343.1	CDS	Rv2827c	NC_000962.2	3134596	3135483	R	Rv2827c, (MTCY16B7.15), len: 295 aa. Hypothetical unknown protein, equivalent to AAK47219 from Mycobacterium tuberculosis strain CDC1551 (315 aa) but shorter 20 aa.; hypothetical protein	complement(3134596..3135483)	Mycobacterium tuberculosis H37Rv	887707
NP_217344.1	CDS	Rv2828c	NC_000962.2	3135788	3136333	R	Rv2828c, (MTCY16B7.14), len: 181 aa. Conserved hypothetical protein, similar to Q9RY53|DR0097 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (189 aa), FASTA scores: opt: 267, E(): 1.9e-11, (34.1% identity in 176 aa overlap); and shows some similarity with N-terminus of O27278|MTH1210 MRR RESTRICTION SYSTEM RELATED PROTEIN from Methanothermobacter thermautotrophicus (340 aa), FASTA scores: opt: 133, E(): 0.07, (28.55% identity in 112 aa overlap). Also equivalent to downstream ORF P71627|Rv2825c|MTCY16B7.17 from Mycobacterium tuberculosis strain H37Rv (alias AAK47217 from strain CDC1551, 246 aa) (215 aa), FASTA scores: opt: 1173, E(): 8.3e-75, (98.9% identity in 181 aa overlap).; hypothetical protein	complement(3135788..3136333)	Mycobacterium tuberculosis H37Rv	887749
NP_217345.1	CDS	Rv2829c	NC_000962.2	3136620	3137012	R	Rv2829c, (MTCY16B7.13), len: 130 aa. Conserved hypothetical protein similar to AAK65872|SMA2253 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (125 aa), FASTA scores: opt: 171, E(): 7.7e-05, (34.9% identity in 129 aa overlap); and shows some similarity with other proteins e.g. Q9AH69 HYPOTHETICAL 14.7 KDA PROTEIN from Neisseria meningitidis (128 aa), FASTA scores: opt: 148, E(): 0.0031, (28.1% identity in 121 aa overlap).; hypothetical protein	complement(3136620..3137012)	Mycobacterium tuberculosis H37Rv	887730
NP_217346.1	CDS	Rv2830c	NC_000962.2	3137009	3137224	R	Rv2830c, (MTCY16B7.12), len: 71 aa. Hypothetical protein, some similarity to Z97182|MTCY19H5.26|Rv0596c Hypothetical protein from Mycobacterium tuberculosis (85 aa), FASTA scores: opt: 88, E(): 1.3, (41.7% identity in 36 aa overlap); and to PHD_BPP1|Q06253 bacteriophage P1 phd gene (73 aa), FASTA scores: opt: 79, E(): 3.8, (35.9% identity in 39 aa overlap).; hypothetical protein	complement(3137009..3137224)	Mycobacterium tuberculosis H37Rv	888537
NP_217347.1	CDS	echA16	NC_000962.2	3137271	3138020	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	3137271..3138020	Mycobacterium tuberculosis H37Rv	888519
NP_217348.1	CDS	ugpC	NC_000962.2	3138099	3139181	R	Rv2832c, (MTCY16B7.10), len: 360 aa. Probable ugpC, Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter (see Braibant et al., 2000), similar to others: CAC48805 PROBABLE GLYCEROL-3-PHOSPHATE ABC TRANSPORTER ATP-BINDING PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (349 aa), FASTA scores: opt: 1018, E(): 4.1e-53, (48.6% identity in 356 aa overlap); Q98G42|MLL3499|UGPC SN-GLYCEROL-3-PHOSPHATE TRANSPORT ATP-BINDING PROTEIN from Rhizobium loti (Mesorhizobium loti) (366 aa), FASTA scores: opt: 1016, E(): 5.6e-53, (48.5% identity in 367 aa overlap). But also highly similar to many msiK proteins, ABC transporter ATP-binding proteins possibly involved in transport of cellolbiose and maltose (see Schlosser et al., 1997) e.g. P96483|MSIK MSIK PROTEIN from Streptomyces reticuli (377 aa), FASTA scores: opt: 1277, E(): 1.9e-68, (58.05% identity in 379 aa overlap); Q9L0Q1|MSIK ABC TRANSPORTER ATP-BINDING PROTEIN from Streptomyces coelicolor (378 aa), FASTA scores: opt: 1276, E(): 2.1e-68, (57.65% identity in 380 aa overlap); Q54333|MSIK from Streptomyces lividans (314 aa), FASTA scores: opt: 1217, E(): 5.9e-65, (63.7% identity in 292 aa overlap); and other ABC-TYPE SUGAR TRANSPORT PROTEINS. Also highly similar to O53482|Rv2038c|MTV018.25c ABC-TYPE SUGAR TRANSPORT PROTEIN from Mycobacterium tuberculosis (357 aa), FASTA scores: opt: 1248, E(): 9.4e-67, (56.8% identity in 354 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONG TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UGPC	complement(3138099..3139181)	Mycobacterium tuberculosis H37Rv	888554
NP_217349.1	CDS	ugpB	NC_000962.2	3139174	3140484	R	Rv2833c, (MTCY16B7.09), len: 436 aa. Probable ugpB, Sn-glycerol-3-phosphate binding lipoprotein component of Sn-glycerol-3-phosphate transport system (see citation below), similar to various transporters substrate-binding periplasmic proteins e.g. Q9KDY2|BH1079 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (GLYCEROL-3-PHOSPHATE BINDING PROTEIN) from Bacillus halodurans (459 aa), FASTA scores: opt: 357, E(): 3.1e-14, (23.4% identity in 406 aa overlap); P72397|MALE PUTATIVE MALTOSE-BINDING PROTEIN from Streptomyces coelicolor (423 aa), FASTA scores: opt: 318, E(): 7e-12, (23.7% identity in 430 aa overlap); AAK78409|CAC0429 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER PERIPLASMIC COMPONENT from Clostridium acetobutylicum (447 aa), FASTA scores: opt: 305, E(): 4.5e-11, (27.15% identity in 438 aa overlap); P10904|UGPB_ECOLI|B3453 GLYCEROL-3-PHOSPHATE-BINDING PERIPLASMIC PROTEIN PRECURSOR from Escherichia coli strain K12 (438 aa); etc. Contains signal sequence and appropriately positioned prokaryotic lipoprotein attachment site (PS00013).; sn-glycerol-3-phosphate-binding lipoprotein UGPB	complement(3139174..3140484)	Mycobacterium tuberculosis H37Rv	888199
NP_217350.1	CDS	ugpE	NC_000962.2	3140487	3141314	R	Rv2834c, (MTCY16B7.08), len: 275 aa. Probable ugpE, Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below), similar to various permeases e.g. Q9KDY3|BH1078 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER from Bacillus halodurans (270 aa), FASTA scores: opt: 620, E(): 4.3e-32, (34.7% identity in 268 aa overlap); Q9X0K6|TM1122 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER PERMEASE PROTEIN from Thermotoga maritima (276 aa), FASTA scores: opt: 605, E(): 3.9e-31, (32.5% identity in 274 aa overlap); AAG58557|UGPE SN-GLYCEROL 3-PHOSPHATE TRANSPORT SYSTEM (INTEGRAL MEMBRANE PROTEIN) from Escherichia coli strain O157:H7 and EDL933 (281 aa), FASTA scores: opt: 574, E(): 3.7e-29, (32.95% identity in 264 aa overlap); P10906|UGPE_ECOLI|B3451 SN-GLYCEROL-3-PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN from Escherichia coli strain K12 (281 aa), FASTA scores: opt: 569, E(): 7.6e-29, (32.6% identity in 264 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.; sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UGPE	complement(3140487..3141314)	Mycobacterium tuberculosis H37Rv	888534
NP_217351.1	CDS	ugpA	NC_000962.2	3141311	3142222	R	Rv2835c, (MTCY1B7.07), len: 303 aa. Probable ugpA, Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below), similar to various permeases e.g. Q9RK71|SCF11.19 PROBABLE SUGAR TRANSPORTER INNER MEMBRANE PROTEIN from Streptomyces coelicolor (316 aa), FASTA scores: opt: 643, E(): 3.1e-35, (38.85% identity in 291 aa overlap); Q9KDY4|BH1077 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (315 aa), FASTA scores: opt: 548, E(): 6.2e-29, (31.5% identity in 295 aa overlap); AAK78407|CAC0427 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER, PERMEASE COMPONENT from Clostridium acetobutylicum (304 aa), FASTA scores: opt: 538, E(): 2.8e-28, (29.1% identity in 292 aa overlap); etc. Contains PS00062 Aldo/keto reductase family signature 2, and PS00402 Binding-protein-dependent transport systems inner membrane comp signature.; sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UGPA	complement(3141311..3142222)	Mycobacterium tuberculosis H37Rv	888569
NP_217352.1	CDS	dinF	NC_000962.2	3142309	3143628	R	Rv2836c, (MTCY16B7.06), len: 439 aa. Possible dinF, DNA-damage-inducible protein F, integral membrane protein, similar to others e.g. BAB38450|ECS5027|AAG59243 from Escherichia coli strain O157:H7 (459 aa), FASTA scores: opt: 501, E(): 2.7e-21, (29.55% identity in 443 aa overlap); P28303|DINF_ECOLI|B4044 from Escherichia coli strain K12 (459 aa), FASTA scores: opt: 491, E(): 1e-20, (29.35% identity in 443 aa overlap); Q98B90|MLR5680 from Rhizobium loti (Mesorhizobium loti) (471 aa), FASTA scores: opt: 466, E(): 2.7e-19, (30.7% identity in 433 aa overlap); etc. But also similar or highly similar to other hypothetical proteins e.g. Q9X8U6|SCH24.32c HYPOTHETICAL 46.3 KDA PROTEIN from Streptomyces coelicolor (448 aa), FASTA scores: opt: 981, E(): 1.1e-48, (42.35% identity in 437 aa overlap). Contains PS00213 Lipocalin signature.; DNA-damage-inducible protein F	complement(3142309..3143628)	Mycobacterium tuberculosis H37Rv	888547
NP_217353.1	CDS	Rv2837c	NC_000962.2	3143635	3144645	R	Rv2837c, (MTCY16B7.05), len: 336 aa. Conserved hypothetical protein, showing some similarity with other proteins e.g. O67552|AQ_1630 HYPOTHETICAL 36.2 KDA PROTEIN from Aquifex aeolicus (325 aa), FASTA scores: opt: 498, E(): 3.6e-25, (32.8% identity in 314 aa overlap); Q9X1T1|TM1595 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (333 aa), FASTA scores: opt: 482, E(): 4.1e-24, (34.85% identity in 304 aa overlap); Q9RW43|DR0826 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (338 aa), FASTA scores: opt: 444, E(): 1.3e-21, (33.85% identity in 331 aa overlap); etc. Equivalent to AAK47229 from Mycobacterium tuberculosis strain CDC1551 (316 aa) but longer 20 aa.; hypothetical protein	complement(3143635..3144645)	Mycobacterium tuberculosis H37Rv	888920
NP_217354.1	CDS	rbfA	NC_000962.2	3144620	3145171	R	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A	complement(3144620..3145171)	Mycobacterium tuberculosis H37Rv	888923
NP_217355.1	CDS	infB	NC_000962.2	3145171	3147873	R	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2	complement(3145171..3147873)	Mycobacterium tuberculosis H37Rv	888157
NP_217356.1	CDS	Rv2840c	NC_000962.2	3147959	3148258	R	Rv2840c, (MTCY16B7.02), len: 99 aa. Conserved hypothetical protein, equivalent to Q9Z5J0|ML1557|MLCB596.13 HYPOTHETICAL 11.6 KDA PROTEIN from Mycobacterium leprae (106 aa), FASTA scores: opt: 501, E(): 2.3e-29, (501% identity in 96 aa overlap). Also highly similar to other hypothetical proteins e.g. Q9KYR0|SC5H4.29 from Streptomyces coelicolor (101 aa), FASTA scores: opt: 256, E(): 1.4e-11, (50.6% identity in 81 aa overlap); Q9APM9 from Myxococcus xanthus (111 aa), FASTA scores: opt: 174, E(): 1.3e-05, (42.25% identity in 97 aa overlap); and similar to to others e.g. N-terminus of CAC41675|SMC02913 from Rhizobium meliloti (Sinorhizobium meliloti) (230 aa), FASTA scores: opt: 172, E(): 3e-05, (42.4% identity in 66 aa overlap).; hypothetical protein	complement(3147959..3148258)	Mycobacterium tuberculosis H37Rv	888189
NP_217357.1	CDS	nusA	NC_000962.2	3148385	3149428	R	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA	complement(3148385..3149428)	Mycobacterium tuberculosis H37Rv	888213
NP_217358.1	CDS	Rv2842c	NC_000962.2	3149425	3149976	R	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein	complement(3149425..3149976)	Mycobacterium tuberculosis H37Rv	888159
NP_217359.1	CDS	Rv2843	NC_000962.2	3150171	3150716	D	Rv2843, (MTCY24A1.14c), len: 181 aa. Probable conserved transmembrane ala-rich protein, equivalent to Q9Z5J3|ML1560|MLCB596.10c HYPOTHETICAL 17.5 KDA PROTEIN from Mycobacterium leprae (178 aa), FASTA scores: opt: 707, E(): 1.4e-32, (70.25% identity in 168 aa overlap).; hypothetical protein	3150171..3150716	Mycobacterium tuberculosis H37Rv	888522
NP_217360.1	CDS	Rv2844	NC_000962.2	3150713	3151201	D	Rv2844, (MTCY24A1.13c), len: 162 aa. Conserved hypothetical ala-rich protein, equivalent to Q9Z5J4|ML1561|MLCB596.09c HYPOTHETICAL 17.5 KDA PROTEIN from Mycobacterium leprae (165 aa), FASTA scores: opt: 771, E(): 4.9e-46, (71.5% identity in 165 aa overlap). Also similar to Q9KYR4|SC5H4.25c HYPOTHETICAL 16.8 KDA PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 242, E(): 1.6e-09, (38.9% identity in 144 aa overlap).; hypothetical protein	3150713..3151201	Mycobacterium tuberculosis H37Rv	888536
NP_217361.1	CDS	proS	NC_000962.2	3151202	3152950	R	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase	complement(3151202..3152950)	Mycobacterium tuberculosis H37Rv	888539
NP_217362.1	CDS	efpA	NC_000962.2	3153039	3154631	R	Rv2846c, (MTCY24A1.11), len: 530 aa. Possible efpA, integral membrane efflux protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug (see citations below), equivalent to Q9Z5J5|ML1562|MLCB596.08 PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Mycobacterium leprae (534 aa), FASTA scores: opt: 2881, E(): 4.1e-160, (86.55% identity in 535 aa overlap). Also highly similar to several membrane proteins e.g. O69986|SC4H2.31c TRANSMEMBRANE EFFLUX PROTEIN (515 aa), FASTA scores: opt: 1063, E(): 2.2e-54, (39.65% identity in 406 aa overlap); Q9FBQ5|SCD86A.02c PUTATIVE TRANSPORT INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (503 aa), FASTA scores: opt: 918, E(): 5.8e-46, (33.7% identity in 469 aa overlap); Q9KYU0|SCE22.23c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (514 aa), FASTA scores: opt: 888, E(): 3.3e-44, (32.85% identity in 469 aa overlap); etc.; integral membrane efflux protein EfpA	complement(3153039..3154631)	Mycobacterium tuberculosis H37Rv	888575
NP_215025.2	CDS	cysG	NC_000962.2	3154654	3155871	R	Rv2847c, (MTCY24A1.10), len: 405 aa. Possible cysG, multifunctional enzyme, siroheme synthase containing uroporphyrin-iii c-methyltransferase (EC 2.1.1.107), precorrin-2 oxidase (EC 1.-.-.-) and ferrochelatase (EC 4.99.1.-). C-terminus highly similar to many uroporphyrin-iii c-methyltransferases e.g. Q51720|COBA UROPORPHYRINOGEN III METHYLTRANSFERASE from Propionibacterium freudenreichii (257 aa), FASTA scores: opt: 776, E(): 1.5e-39, (48.95% identity in 243 aa overlap); Q9HMY4|UROM|VNG2331G S-ADENOSYL-L-METHIONINE:UROPORPHYRINOGEN III METHYLTRANSFERASE from Halobacterium sp. strain NRC-1 (246 aa), FASTA scores: opt: 704, E(): 3.1e-35, (49.4% identity in 245 aa overlap); P42437|NASF_BACSU|NASBE UROPORPHYRIN-III C-METHYLTRANSFERASE from Bacillus subtilis (483 aa), FASTA scores: opt: 610, E(): 2.4e-29, (42.1% identity in 240 aa overlap); etc. And highly similar over entire length to other proteins e.g. Q9L1C9|SCL11.09c UROPORPHYRINOGEN III METHYLTRANSFERASE from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1481, E(): 5.6e-82, (58.45% identity in 409 aa overlap); Q9I0M7|CYSG|PA2611 SIROHEME SYNTHASE from Pseudomonas aeruginosa (465 aa), FASTA scores: opt: 609, E(): 2.7e-29, (34.7% identity in 444 aa overlap); P11098|CYSG_ECOLI|B3368|Z4729|ECS4219 SIROHEME SYNTHASE from Escherichia coli stains O157:H7 and K12 (457 aa), FASTA scores: opt: 543, E(): 9.1e-27, (31.3% identity in 450 aa overlap); etc. BELONGS TO A FAMILY THAT GROUPS SUMT, CYSG, CBIF/COBM AND CBIL/COBI. Note that previously known as cysG2.; cysG2; multifunctional uroporphyrinogen III methylase/precorrin-2 oxidase/ferrochelatase	complement(3154654..3155871)	Mycobacterium tuberculosis H37Rv	887481
NP_217364.1	CDS	cobB	NC_000962.2	3156148	3157521	R	responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase	complement(3156148..3157521)	Mycobacterium tuberculosis H37Rv	888499
YP_177908.1	CDS	cobO	NC_000962.2	3157521	3158144	R	catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase	complement(3157521..3158144)	Mycobacterium tuberculosis H37Rv	888236
NP_217366.1	CDS	Rv2850c	NC_000962.2	3158165	3160054	R	Rv2850c, (MTCY24A1.07), len: 629 aa. Possible magnesium-chelatase (EC 4.99.1.-), highly similar (but with gaps) to magnesium-chelatases from notably photosynthetic organisms involved in chlorophyll biosynthesis e.g. Q9RJ18|SCI8.35c PUTATIVE CHELATASE from Streptomyces coelicolor (672 aa), FASTA scores: opt: 1941, E(): 2.1e-85, (54.65% identity in 675 aa overlap); Q9HZQ5|PA2942 PROBABLE MAGNESIUM CHELATASE from Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 991, E(): 2.7e-40, (49.45% identity in 368 aa overlap); O33549|BCHI MG PROTOPORPHYRIN IX CHELATASE SUBUNIT from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (334 aa), FASTA scores: opt: 833, E(): 9.4e-33, (50.65% identity in 318 aa overlap); O30819|BCHI_RHOSH MAGNESIUM-CHELATASE 38 KDA SUBUNIT from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (334 aa), FASTA scores: opt: 828, E(): 1.6e-32, (50.3% identity in 318 aa overlap); etc. Equivalent to AAK47242 from Mycobacterium tuberculosis strain CDC1551 (610 aa) but longer 19 aa. COULB BELONG TO THE MG-CHELATASE SUBUNITS D/I FAMILY.; magnesium chelatase	complement(3158165..3160054)	Mycobacterium tuberculosis H37Rv	887364
NP_217367.1	CDS	Rv2851c	NC_000962.2	3160051	3160521	R	Rv2851c, (MTCY24A1.06), len: 156 aa. Conserved hypothetical protein, similar to various bacterial proteins e.g. Q9KP14|VC2565 ELAA PROTEIN from Vibrio cholerae (149 aa), FASTA scores: opt: 360, E(): 1e-18, (46.05% identity in 139 aa overlap); Q9I717|PA0115 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (150 aa), FASTA scores: opt: 341, E(): 2.4e-17, (43.65% identity in 142 aa overlap); Q9K8M4|BH2982 HYPOTHETICAL PROTEIN from Bacillus halodurans (155 aa), FASTA scores: opt: 320, E(): 8e-16, (40.85% identity in 142 aa overlap); P52077|ELAA_ECOLI|B2267 PROTEIN ELAA from Escherichia coli strain K12 (153 aa), FASTA scores: opt: 269, E(): 3.8e-12, (35.7% identity in 140 aa overlap); etc.; hypothetical protein	complement(3160051..3160521)	Mycobacterium tuberculosis H37Rv	887664
NP_217368.1	CDS	mqo	NC_000962.2	3160580	3162061	R	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase	complement(3160580..3162061)	Mycobacterium tuberculosis H37Rv	888544
YP_177909.1	CDS	PE_PGRS48	NC_000962.2	3162268	3164115	D	Rv2853, (MTCY24A1.04c), len: 615 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to many e.g. O53884|Rv0872c|MTV043.65c from Mycobacterium tuberculosis (606 aa), FASTA scores: opt: 1405, E(): 1.4e-97, (64.6% identity in 619 aa overlap). Equivalent to AAK47245 from Mycobacterium tuberculosis strain CDC1551 (663 aa) but shorter 48 aa.; PE-PGRS family protein	3162268..3164115	Mycobacterium tuberculosis H37Rv	888171
NP_217370.1	CDS	Rv2854	NC_000962.2	3164152	3165192	D	Rv2854, (MTCY24A1.03c), len: 346 aa. Hypothetical unknown protein, showing similarity with Q9CD03|ML2603 HYPOTHETICAL PROTEIN from Mycobacterium leprae (279 aa), FASTA scores: opt: 154, E(): 0.0083, (33.35% identity in 87 aa overlap).; hypothetical protein	3164152..3165192	Mycobacterium tuberculosis H37Rv	888542
YP_177910.1	CDS	mtr	NC_000962.2	3165205	3166584	D	catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; mycothione reductase	3165205..3166584	Mycobacterium tuberculosis H37Rv	887773
NP_217372.1	CDS	nicT	NC_000962.2	3166684	3167802	D	Rv2856, (MTCY24A1.01c), len: 372 aa. Possible nicT, nickel-transport integral membrane protein, similar to transport proteins and hydrogenase cluster proteins e.g. BAB58860|SAV2698 HYPOTHETICAL 37.9 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (338 aa), FASTA scores: opt: 1082, E(): 7.1e-60, (48.05% identity in 335 aa overlap); Q97ZB2|HOXN HIGH-AFFINITY NICKEL-TRANSPORT PROTEIN from Sulfolobus solfataricus (373 aa), FASTA scores: opt: 922, E(): 6.6e-50, (42.2% identity in 372 aa overlap); P23516|HOXN_ALCEU HIGH-AFFINITY NICKEL TRANSPORT PROTEIN (INTEGRAL MEMBRANE PROTEIN) from Alcaligenes eutrophus (Ralstonia eutropha) (351 aa), FASTA scores: opt: 904, E(): 8.3e-49, (41.9% identity in 339 aa overlap); Q45247|HUPN_BRAJA HYDROGENASE NICKEL INCORPORATION PROTEIN from Bradyrhizobium japonicum (381 aa), FASTA scores: opt: 853, E(): 1.3e-45, (41.65% identity in 329 aa overlap); etc. SEEMS TO BELONG TO THE HOXN/HUPN/NIXA FAMILY OF NICKEL TRANSPORTERS (NiCoT FAMILY).; nickel-transport integral membrane protein	3166684..3167802	Mycobacterium tuberculosis H37Rv	888643
NP_217373.1	CDS	Rv2857c	NC_000962.2	3168583	3169359	R	Rv2857c, (MTV003.03c), len: 258 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases e.g. O88068|SCI35.33c PROBABLE DEHYDROGENASE (SDR FAMILY) from Streptomyces coelicolor (260 aa), FASTA scores: opt: 1208, E(): 2e-68, (72.35% identity in 253 aa overlap); Q9I376|PA1649 from Pseudomonas aeruginosa PROBABLE SHORT-CHAIN DEHYDROGENASE (253 aa), FASTA scores: opt: 569, E(): 2.1e-28, (39.2% identity in 255 aa overlap); Q9EX74|MLHA SDR-LIKE ENZYME from Rhodococcus erythropolis (246 aa), FASTA scores: opt: 567, E(): 2.8e-28, (41.15% identity in 248 aa overlap); etc. Also similar to many Mycobacterium tuberculosis dehydrogenases e.g. FABG3|Rv2002|MT2058|MTCY39.16c PUTATIVE OXIDOREDUCTASE (260 aa), FASTA score: (38.3% identity in 248 aa overlap). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short chain dehydrogenase	complement(3168583..3169359)	Mycobacterium tuberculosis H37Rv	888560
NP_217374.1	CDS	aldC	NC_000962.2	3169356	3170723	R	Rv2858c, (MTV003.04c), len: 455 aa. Probable aldC, aldehyde dehydrogenase (EC 1.2.1.3), similar to many e.g. O88069|SCI35.34c PUTATIVE ALDEHYDE DEHYDROGENASE from Streptomyces coelicolor (483 aa), FASTA scores: opt: 1872, E(): 6.4e-109, (64.5% identity in 448 aa overlap); Q9FAB1|ALDH|BT-ALDH ALDEHYDE DEHYDROGENASE from Bacillus thermoleovorans (497 aa), FASTA scores: opt: 1157, E(): 2.1e-64, (44.3% identity in 458 aa overlap); O33455|CYMC P-CUMIC ALDEHYDE DEHYDROGENASE from Pseudomonas putida (494 aa), FASTA scores: opt: 1149, E(): 6.5e-64, (43.15% identity in 452 aa overlap); P40047|DHA5_YEAST|ALD5|ALDH5|ALD3|YER073W ALDEHYDE DEHYDROGENASE from Saccharomyces cerevisiae (Baker's yeast) (519 aa), FASTA scores: opt: 1091, E(): 2.7e-60, (38.55% identity in 459 aa overlap); P80668|FEAB_ECOLI|PADA|MAOB|B1385 PHENYLACETALDEHYDE DEHYDROGENASE (EC 1.2.1.39) from Escherichia coli strain K12 (499 aa), FASTA scores: opt: 1074, E(): 3e-59, (42.2% identity in 462 aa overlap); etc. Also similar to many M. tuberculosis dehydrogenases e.g. P71823|Rv0768|MTCY369.13 (489 aa), FASTA score: (38.1% identity in 467 aa overlap). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY.; aldehyde dehydrogenase	complement(3169356..3170723)	Mycobacterium tuberculosis H37Rv	888636
NP_217375.1	CDS	Rv2859c	NC_000962.2	3170720	3171646	R	Rv2859c, (MTV003.05c), len: 308 aa. Possible amidotransferase (EC 6.3.5.- or 2.-.-.-), equivalent (but longer 58 aa) to Q9CBU9|ML1573 POSSIBLE AMIDOTRANSFERASE from Mycobacterium leprae (249 aa), FASTA scores: opt: 1226, E(): 3e-64, (71.55% identity in 239 aa overlap). Also similar to other amidotransferases and hypothetical proteins, but shorter in N-terminus e.g. O88072|SCI35.37 HYPOTHETICAL 25.3 KDA PROTEIN from Streptomyces coelicolor (242 aa), FASTA scores: opt: 683, E(): 1.2e-32, (47.65% identity in 235 aa overlap); AAK79730|Q97I88|CAC1764 PREDICTED GLUTAMINE AMIDOTRANSFERASE from Clostridium acetobutylicum (241 aa), FASTA scores: opt: 458, E(): 1.6e-19, (32.95% identity in 246 aa overlap); AAK75201|Q97QV9|SP1089 GLUTAMINE AMIDOTRANSFERASE CLASS I from Streptococcus pneumoniae (229 aa), FASTA scores: opt: 431, E(): 5.6e-18, (34.75% identity in 236 aa overlap); etc. Contains three 17 aa repeats at the N-terminus very similar to those in other Mycobacterium tuberculosis proteins e.g. Q10699|YY30_MYCTU|Rv2090|MT2151|MTCY49.30 PUTATIVE 5'-3' EXONUCLEASE RV2090 (EC 3.1.11.-).; amidotransferase	complement(3170720..3171646)	Mycobacterium tuberculosis H37Rv	887495
NP_217376.1	CDS	glnA4	NC_000962.2	3171627	3173000	R	Rv2860c, (MTV003.06c), len: 457 aa. Probable glnA4, glutamine synthetase class II (EC 6.3.1.2), similar to many glutamine synthases e.g. O88070|SCI35.35c from Streptomyces coelicolor (462 aa), FASTA scores: opt: 1947, E(): 8.2e-120, (64.15% identity in 452 aa overlap); Q98H15|MLL3074 from Rhizobium loti (Mesorhizobium loti) (465 aa), FASTA scores: opt: 1321, E(): 7.8e-79, (46.7% identity in 452 aa overlap); Q98EM0|MLL4187 from Rhizobium loti (Mesorhizobium loti) (456 aa), FASTA scores: opt: 698, E(): 4.6e-38, (33.5% identity in 454 aa overlap); Q9CDL9|GLNA from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (446 aa), FASTA scores: opt: 633, E(): 8.2e-34, (32.45% identity in 456 aa overlap); etc. Also similar to three other potential glutamine synthases in Mycobacterium tuberculosis: Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY42 7. 03c PROBABLE GLUTAMINE SYNTHETASE (446 aa), FASTA score: (31.1% identity in 453 aa overlap); Rv1878|glnA3 and Rv2220|glnA1. BELONGS TO THE GLUTAMINE SYNTHETASE FAMILY.; glutamine synthetase	complement(3171627..3173000)	Mycobacterium tuberculosis H37Rv	887420
YP_177911.1	CDS	mapB	NC_000962.2	3173160	3174017	R	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase	complement(3173160..3174017)	Mycobacterium tuberculosis H37Rv	888596
NP_217378.1	CDS	Rv2862c	NC_000962.2	3174059	3174643	R	Rv2862c, (MTV003.08), len: 194 aa. Conserved hypothetical protein, showing some similarity with others e.g. Q9X8X5|SCH35.31c HYPOTHETICAL 19.6 KDA PROTEIN from Streptomyces coelicolor (180 aa), FASTA scores: opt: 266, E(): 2.2e-11, (34.65% identity in 179 aa overlap); Q9Z5H1|ML0169|MLCB373.19 HYPOTHETICAL 22.1 KDA PROTEIN from Mycobacterium leprae (200 aa), FASTA scores: opt: 195, E(): 2.3e-06, (30.15% identity in 189 aa overlap); etc. Also some similarity to P71544|Y966_MYCTU|Rv0966c|MT0994|MTCY10D7.08 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (230 aa), FASTA scores: opt: 209, E(): 2.6e-07, (31.5% identity in 184 aa overlap).; hypothetical protein	complement(3174059..3174643)	Mycobacterium tuberculosis H37Rv	887423
NP_217379.1	CDS	Rv2863	NC_000962.2	3174992	3175372	D	Rv2863, (MTV003.09), len: 126 aa. Conserved hypothetical protein, similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Q50595|YI38_MYCTU|Rv1838c|MT1886|MTCY1A11.05|MTCY359.35 CONSERVED HYPOTHETICAL PROTEIN (131 aa), FASTA scores: opt: 299, E(): 6.5e-15, (39.0% identity in 123 aa overlap).; hypothetical protein	3174992..3175372	Mycobacterium tuberculosis H37Rv	888195
NP_217380.1	CDS	Rv2864c	NC_000962.2	3175454	3177265	R	Rv2864c, (MTV003.10c), len: 603 aa. Possible penicillin-binding lipoprotein, probably located in periplasm, equivalent to Q9CBU6|ML1577 PROBABLE PENICILLIN BINDING PROTEIN from Mycobacterium leprae (608 aa), FASTA scores: opt: 3352, E(): 2.1e-193, (81.5% identity in 606 aa overlap). Also shows some similarity to others e.g. P72405|PCBR from Streptomyces clavuligerus (551 aa), FASTA scores: opt: 543, E(): 6.1e-25, (28.4% identity in 567 aa overlap); Q9F2L0|SCH63.18c from Streptomyces coelicolor (546 aa), FASTA scores: opt: 519, E(): 1.7e-23, (29.3% identity in 577 aa overlap); Q9RKD1|SCE87.07 from Streptomyces coelicolor (541 aa), FASTA scores: opt: 472, E(): 1.1e-20, (34.3% identity in 318 aa overlap); etc. Equivalent to AAK47258 from Mycobacterium tuberculosis strain CDC1551 (618 aa) but shorter 15 aa. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and PS00017 ATP/GTP-binding site motif A (P-loop).; penicillin-binding lipoprotein	complement(3175454..3177265)	Mycobacterium tuberculosis H37Rv	888496
NP_217381.1	CDS	Rv2865	NC_000962.2	3177537	3177818	D	Rv2865, (MTV003.11), len: 93 aa. Conserved hypothetical protein, showing weak similarity with P58235|YR54_SYNY3|SSR2754 HYPOTHETICAL 9.7 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (87 aa), FASTA scores: opt: 134, E(): 0.007, (30.65% identity in 75 aa overlap); BAB58570|SAV2408 CONSERVED HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (83 aa), FASTA scores: opt: 124, E(): 0.037, (27.5% identity in 80 aa overlap). Also similar to Rv1247|MTV006.19c HYPOTHETICAL 9.8 KDA PROTEIN from Mycobacterium tuberculosis (89 aa), FASTA scores: opt: 249, E(): 2.6e-11, (44.2% identity in 86 aa overlap).; hypothetical protein	3177537..3177818	Mycobacterium tuberculosis H37Rv	887458
NP_217382.1	CDS	Rv2866	NC_000962.2	3177822	3178085	D	Rv2866, (MTV003.12), len: 87 aa. Conserved hypothetical protein, similar to O50461|Rv1246c|MTV006.18c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (97 aa), FASTA scores: opt: 290, E(): 3.6e-16, (54.1% identity in 85 aa overlap).; hypothetical protein	3177822..3178085	Mycobacterium tuberculosis H37Rv	887450
NP_217383.1	CDS	Rv2867c	NC_000962.2	3178458	3179312	R	Rv2867c, (MTV003.13c), len: 284 aa. Conserved hypothetical protein, similar to Q9KYR8|SC5H4.21 HYPOTHETICAL 31.3 KDA PROTEIN from Streptomyces coelicolor (287 aa), FASTA scores: opt: 798, E(): 2.4e-45, (47.95% identity in 269 aa overlap).; hypothetical protein	complement(3178458..3179312)	Mycobacterium tuberculosis H37Rv	887475
NP_217384.1	CDS	ispG	NC_000962.2	3179368	3180531	R	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase	complement(3179368..3180531)	Mycobacterium tuberculosis H37Rv	887463
NP_217385.1	CDS	Rv2869c	NC_000962.2	3180548	3181762	R	Rv2869c, (MTV003.15c), len: 404 aa. Probable conserved transmembrane protein, equivalent to Q9CBU4|ML1582 PROBABLE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (404 aa), FASTA scores: opt: 2250, E(): 1.1e-128, (82.2% identity in 404 aa overlap). Also weakly similar to other membrane proteins or hypothetical proteins e.g. Q9A710|CC1916 PUTATIVE MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE from Caulobacter crescentus (398 aa), FASTA scores: opt: 368, E(): 7.8e-15, (28.1% identity in 427 aa overlap).; transmembrane protein	complement(3180548..3181762)	Mycobacterium tuberculosis H37Rv	887449
NP_217386.2	CDS	dxr	NC_000962.2	3181770	3183011	R	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase	complement(3181770..3183011)	Mycobacterium tuberculosis H37Rv	887800
NP_217387.1	CDS	Rv2871	NC_000962.2	3183138	3183395	D	Rv2871, (MTCY274.02), len: 85 aa. Conserved hypothetical protein (see citation below), similar to other CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50456|Rv1241|MTV006.13 (86 aa), FASTA scores: opt: 172, E(): 2.9e-05, (37.2% identity in 86 aa overlap); O53811|Rv0748|MTV041.22 (85 aa), FASTA scores: opt: 170, E(): 4e-05, (35.3% identity in 85 aa overlap); etc.; hypothetical protein	3183138..3183395	Mycobacterium tuberculosis H37Rv	887468
NP_217388.1	CDS	Rv2872	NC_000962.2	3183382	3183825	D	Rv2872, (MTCY274.03), len: 147 aa. Conserved hypothetical protein (see citation below), similar to other CONSERVED HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53683|Rv0277c|MTV035.05c (142 aa), FASTA scores: opt: 357, E(): 1.4e-17, (41.45% identity in 140 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 350, E(): 4.3e-17, (41.55% identity in 142 aa overlap); etc.; hypothetical protein	3183382..3183825	Mycobacterium tuberculosis H37Rv	887361
NP_217389.1	CDS	mpt83	NC_000962.2	3183905	3184567	D	Rv2873, (MTCY274.04), len: 220 aa. mpt83 (alternate gene name: mpb83), cell surface lipoprotein (see citations below). Also similar to upstream ORF Q50769|MP70_MYCTU|MPT70|MPB70|Rv2875|MT2943|MTCY274.06 which is also known as MAJOR SECRETED IMMUNOGENIC PROTEIN MPT70 PRECURSOR from Mycobacterium tuberculosis (193 aa), FASTA scores: opt: 806, E(): 2.7e-38, (70.25% identity in 185 aa overlap). BELONGS TO THE MPT70 / MPT83 FAMILY. ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR.; mpb83; cell surface lipoprotein mpt83 (lipoprotein P23)	3183905..3184567	Mycobacterium tuberculosis H37Rv	887155
NP_217390.1	CDS	dipZ	NC_000962.2	3184847	3186934	D	Rv2874, (MT2942, MTCY274.05), len: 695 aa. Possible dipZ, cytochrome c-type biogenesis protein (see citation below), probable integral membrane protein, similar in part to others or hypothetical proteins e.g. CAC48606|SMB20213 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (627 aa), FASTA scores: opt: 844, E(): 7.3e-43, (32.65% identity in 643 aa overlap); Q9ZMH0|CCDA OR JHP0250 PUTATIVE CYTOCHROME C-TYPE BIOGENESIS PROTEIN from Helicobacter pylori J99 (Campylobacter pylori J99) (239 aa), FASTA scores: opt: 250, E(): 1.4e-07, (27.3% identity in 227 aa overlap); Q9LA04|CCDA C-TYPE CYTOCHROME BIOGENESIS PROTEIN from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (252 aa), FASTA scores: opt: 245, E(): 2.9e-07, (27.85% identity in 244 aa overlap); etc. Also similar to O06393|CCSA|Rv0527|MTCY25D10.06 CYTOCHROME C-TYPE BIOGENESIS PROTEIN from Mycobacterium tuberculosis (259 aa), FASTA scores: opt: 280, E(): 2.4e-09, (29.3% identity in 239 aa overlap).; integral membrane C-type cytochrome biogenesis protein DipZ	3184847..3186934	Mycobacterium tuberculosis H37Rv	888162
NP_217391.1	CDS	mpt70	NC_000962.2	3187030	3187611	D	Rv2875, (MTCY274.06), len: 193 aa. mpt70 (alternate gene name: mpb70), major secreted immunogenic protein MPT70 precursor (see citations below). Also similar to downstream ORF Q10790|MP83_MYCTU|MPT83|MPB83|Rv2873|MT2940|MTCY274.04 CELL SURFACE LIPOPROTEIN MPT83 PRECURSOR (LIPOPROTEIN P23) (220 aa), FASTA scores: opt: 806, E(): 1.2e-40, (70.25% identity in 185 aa overlap). BELONGS TO THE MPT70 / MPT83 FAMILY. GENERALLY FOUND AS A MONOMER; HOMODIMER IN CULTURE FLUIDS.; mpb70; major secreted immunogenic protein MPT70	3187030..3187611	Mycobacterium tuberculosis H37Rv	887724
NP_217392.1	CDS	Rv2876	NC_000962.2	3187663	3187977	D	Rv2876, (MTCY274.07), len: 104 aa. Possible conserved transmembrane protein, equivalent (but longer 16 aa) to Q9CBU2|ML1584 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (84 aa), FASTA scores: opt: 444, E(): 8.3e-26, (73.85% identity in 88 aa overlap).; transmembrane protein	3187663..3187977	Mycobacterium tuberculosis H37Rv	887823
YP_177912.1	CDS	Rv2877c	NC_000962.2	3188008	3188871	R	Rv2877c, (MTCY274.08c), len: 287 aa. Probable conserved integral membrane protein, Mer family possibly involved in transport of mercury, similar to others, and to the fourth protein of the mercury resistance operon of Streptomyces sp (or other organisms), and to putative cytochrome-c biogenesis proteins e.g. Q9XBD1|CZA382.20C PUTATIVE INTEGRAL MEMBRANE TRANSPORTER from Amycolatopsis orientalis (298 aa), FASTA scores: opt: 913, E(): 7.6e-46, (51.55% identity in 293 aa overlap); P30344|MER4_STRLI MERCURY RESISTANCE PROBABLE HG TRANSPORT PROTEIN from Streptomyces lividans (319 aa), FASTA scores: opt: 427, E(): 1.2e-17, (32.85% identity in 289 aa overlap); Q9M5P3 PUTATIVE CYTOCHROME C BIOGENESIS PROTEIN PRECURSOR from Arabidopsis thaliana (Mouse-ear cress) (354 aa), FASTA scores: opt: 229, E(): 4e-06, (29.85% identity in 221 aa overlap); etc. Contains PS00044 Bacterial regulatory proteins, lysR family signature. Note that previously known as merT.; merT; integral membrane protein	complement(3188008..3188871)	Mycobacterium tuberculosis H37Rv	887196
NP_217394.1	CDS	mpt53	NC_000962.2	3188876	3189397	R	Rv2878c, (MT2946, MTCY274.09c), len: 173 aa. mpt53, secreted protein (contains N-terminal signal sequence) (see citations below). Shows some similarity with several disulfide bond interchange proteins e.g. P43787|THIX_HAEIN THIOREDOXIN-LIKE PROTEIN HI1115 from Haemophilus influenzae (167 aa), FASTA scores: opt: 200, E(): 1.4e-06, (28.9% identity in 135 aa overlap); P52237|TIPB_PSEFL THIOL:DISULFIDE INTERCHANGE PROTEIN TIPB PRECURSOR (CYTOCHROME C BIOGENESIS PROTEIN TIPB) (178 aa), FASTA scores: opt: 184, E(): 1.8e-05, (26.3% identity in 171 aa overlap); etc. Also highly similar to O53924|DSBF|Rv1677|MTV047.12 PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (182 aa), FASTA scores: opt: 482, E(): 5.7e-26, (52.8% identity in 142 aa overlap). COULD BE BELONG TO THE THIOREDOXIN FAMILY. Note that also previously known as dsbE.; dsbE; soluble secreted antigen MPT53 precursor	complement(3188876..3189397)	Mycobacterium tuberculosis H37Rv	887184
NP_217395.1	CDS	Rv2879c	NC_000962.2	3189583	>3190152	R	Rv2879c, (MTCY274.10c), len: 189 aa. Conserved hypothetical protein, similar to others e.g. C-terminus of Q9RVT6|DR0936 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (346 aa), FASTA scores: opt: 505, E(): 1e-26, (46.5% identity in 185 aa overlap); O34617|YLON_BACSU HYPOTHETICAL 41.6 KDA PROTEIN from Bacillus subtilis (363 aa), FASTA scores: opt: 459, E(): 1.2e-24, (40.5% identity in 185 aa overlap); YFGB_ECOLI|P36979 hypothetical 43.1 kDa protein from Escherichia coli (384 aa), FASTA scores, opt: 410, E(): 2.8e-21, (41.7% identity in 187 aa overlap); etc. Appears to be a frame shift with respect to following ORF but we can detect no error in the cosmid sequence to account for this.; hypothetical protein	complement(3189583..>3190152)	Mycobacterium tuberculosis H37Rv	887156
NP_217396.1	CDS	Rv2880c	NC_000962.2	3189851	3190678	R	Rv2880c, (MTCY274.11c), len: 275 aa. Conserved hypothetical protein, highly similar in N-terminus to others e.g. O86754|SC6A9.22c HYPOTHETICAL 40.4 KDA PROTEIN from Streptomyces coelicolor (368 aa), FASTA scores: opt: 663, E(): 2.6e-33, (52.6% identity in 213 aa overlap); Q55880|Y098_SYNY3|SLL0098 HYPOTHETICAL 38.9 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (350 aa), FASTA scores: opt: 362, E(): 7.3e-15, (38.9% identity in 162 aa overlap); O66732|AQ_416 HYPOTHETICAL 40.2 KDA PROTEIN from Aquifex aeolicus (348 aa), FASTA scores: opt: 321, E(): 2.4e-12, (39.75% identity in 146 aa overlap); etc. Appears to be a frame shift with respect to preceding ORF but we can detect no error in the cosmid sequence to account for this.; hypothetical protein	complement(3189851..3190678)	Mycobacterium tuberculosis H37Rv	887810
NP_217397.1	CDS	cdsA	NC_000962.2	3190701	3191621	R	Rv2881c, (MTCY274.12c), len: 306 aa. Probable cdsA, phosphatidate cytidylyltransferase (EC 2.7.7.41), integral membrane protein, equivalent to Q9CBU1|CDSA_MYCLE|ML1589 PHOSPHATIDATE CYTIDYLYLTRANSFERASE from Mycobacterium leprae (312 aa), FASTA scores: opt: 1470, E(): 1.1e-84, (70.3% identity in 313 aa overlap). Also similar to others e.g. Q9KPV7|VC2255 from Vibrio cholerae (280 aa), FASTA scores: opt: 383, E(): 1.1e-16, (29.3% identity in 280 aa overlap); Q9CDT2|CDSA from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (267 aa), FASTA scores: opt: 361, E(): 2.6e-15, (29.05% identity in 265 aa overlap); P06466|CDSA_ECOLI|CDS|B0175|Z0186|ECS0177 from Escherichia coli strains K12 and O157:H7 (249 aa), FASTA scores: opt: 352, E(): 9.2e-15, (40.4% identity in 156 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CDS FAMILY.; integral membrane phosphatidate cytidylyltransferase CdsA	complement(3190701..3191621)	Mycobacterium tuberculosis H37Rv	888910
NP_217398.1	CDS	frr	NC_000962.2	3191644	3192201	R	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor	complement(3191644..3192201)	Mycobacterium tuberculosis H37Rv	887464
NP_217399.1	CDS	pyrH	NC_000962.2	3192373	3193158	R	Catalyzes the phosphorylation of UMP to UDP; uridylate kinase	complement(3192373..3193158)	Mycobacterium tuberculosis H37Rv	887709
NP_217400.1	CDS	Rv2884	NC_000962.2	3193393	3194151	D	Rv2884, (MTCY274.15), len: 252 aa. Probable transcriptional regulatory protein, highly similar to others e.g. Q05943|GLNR_STRCO|SCD84.26c TRANSCRIPTIONAL REGULATORY PROTEIN from Streptomyces coelicolor (267 aa), FASTA scores: opt: 609, E(): 2.7e-34, (46.4% identity in 224 aa overlap); Q55733|SLL0396 REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM from Synechocystis sp. strain PCC 6803 (224 aa), FASTA scores: opt: 330, E(): 3e-15, (31.8% identity in 217 aa overlap); Q9A4S3|CC2757 DNA-BINDING RESPONSE REGULATOR from Caulobacter crescentus (223 aa), FASTA scores: opt: 311, E(): 6e-14, (30.3% identity in 221 aa overlap); etc. Also highly similar to O53830|Rv0818|MTV043.10 PUTATIVE REGULATORY PROTEIN from Mycobacterium tuberculosis (255 aa), FASTA scores: opt: 665, E(): 3.8e-38, (47.6% identity in 227 aa overlap). THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS.; transcriptional regulatory protein	3193393..3194151	Mycobacterium tuberculosis H37Rv	887443
NP_217401.1	CDS	Rv2885c	NC_000962.2	3194166	3195548	R	Rv2885c, (MTCY274.16c), len: 460 aa. Probable transposase for IS1539. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; transposase	complement(3194166..3195548)	Mycobacterium tuberculosis H37Rv	887173
NP_217402.1	CDS	Rv2886c	NC_000962.2	3195545	3196432	R	Rv2886c, (MTCY274.17c), len: 295 aa. Probable resolvase for IS1539. Contains PS00213 Lipocalin signature.; resolvase	complement(3195545..3196432)	Mycobacterium tuberculosis H37Rv	887424
NP_217403.1	CDS	Rv2887	NC_000962.2	3196431	3196850	D	Rv2887, (MTCY274.18), len: 139 aa. Probable transcriptional regulatory protein, highly similar to Q9EX59|SC1A4.04 PUTATIVE MARR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (151 aa), FASTA scores: opt: 354, E(): 6.6e-16, (42.95% identity in 135 aa overlap); and similar to others e.g. AAF97817|SLYA TRANSCRIPTIONAL REGULATOR SLYA from Escherichia coli strain EPEC 2348/69 (146 aa), FASTA scores: opt: 181, E(): 0.0001, (27.25% identity in 132 aa overlap); P55740|SLYA_ECOLI|AAG56631|B1642|Z2657|ECS2351 TRANSCRIPTIONAL REGULATOR SLYA from Escherichia coli strains K12 and O157:H7 (146 aa), FASTA scores: opt: 177, E(): 0.00018, (27.25% identity in 132 aa overlap) ; etc. Contains probable helix-turn-helix motif at aa 50-71 (Score 1182, +3.21 SD).; transcriptional regulatory protein	3196431..3196850	Mycobacterium tuberculosis H37Rv	888563
NP_217404.1	CDS	amiC	NC_000962.2	3196864	3198285	R	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase	complement(3196864..3198285)	Mycobacterium tuberculosis H37Rv	887401
NP_217405.1	CDS	tsf	NC_000962.2	3198292	3199107	R	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts	complement(3198292..3199107)	Mycobacterium tuberculosis H37Rv	888187
NP_217406.1	CDS	rpsB	NC_000962.2	3199119	3199982	R	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2	complement(3199119..3199982)	Mycobacterium tuberculosis H37Rv	887187
NP_217407.1	CDS	Rv2891	NC_000962.2	3200266	3201015	D	Rv2891, (MTCY274.22), len: 249 aa (C-terminus overlaps neigbouring ORF). Conserved hypothetical protein, similar in N-terminus to O69910|SC2E1.40c HYPOTHETICAL 22.8 KDA PROTEIN from Streptomyces coelicolor (226 aa), FASTA scores: opt: 315, E(): 3.4e-11, (40.7% identity in 145 aa overlap).; hypothetical protein	3200266..3201015	Mycobacterium tuberculosis H37Rv	888328
YP_177913.1	CDS	PPE45	NC_000962.2	3200794	3202020	R	Rv2892c, (MTCY274.23c), len: 408 aa. Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O06386|Rv3621c|MTCY15C10.31|MTCY07H7B.01 from M. tuberculosis (413 aa), FASTA scores: opt: 957, E(): 6.2e-46, (44.7% identity in 423 aa overlap).; PPE family protein	complement(3200794..3202020)	Mycobacterium tuberculosis H37Rv	887824
NP_217409.1	CDS	Rv2893	NC_000962.2	3202420	3203397	D	Rv2893, (MTCY274.24), len: 325 aa. Possible oxidoreductase (EC 1.-.-.-), showing similarity with various proteins and/or oxidoreductases e.g. Q9AE05|RIF11 eleventh protein in the rif biosynthetic gene cluster from Amycolatopsis mediterranei (Nocardia mediterranei) (294 aa), FASTA scores: opt: 270, E(): 4.8e-10, (34.5% identity in 313 aa overlap); O52567 REDUCTASE from Amycolatopsis mediterranei (Nocardia mediterranei) (153 aa), FASTA scores: opt: 251, E(): 5e-09, (42.4% identity in 125 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 249, E(): 1.2e-08, (29.7% identity in 283 aa overlap); etc. Also some similarity with others proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. P71844|Rv0791c|MTCY369.35c PUTATIVE OXIDOREDUCTASE (347 aa), FASTA scores: opt: 264, E(): 1.3e-09, (29.05% identity in 272 aa overlap); and P96809|Rv0132|MTCI5.06c PUTATIVE OXIDOREDUCTASE (360 aa), FASTA scores: opt: 260, E(): 2.4e-09, (33.05% identity in 239 aa overlap).; oxidoreductase	3202420..3203397	Mycobacterium tuberculosis H37Rv	887337
NP_217410.1	CDS	xerC	NC_000962.2	3203394	3204290	R	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC	complement(3203394..3204290)	Mycobacterium tuberculosis H37Rv	887392
NP_217411.1	CDS	viuB	NC_000962.2	3204381	3205232	R	Rv2895c, (MT2963, MTCY274.26c), len: 283 aa. Possible viuB, mycobactin utilization protein, highly similar to Q9RJ78|SCI41.06 HYPOTHETICAL 31.5 KDA PROTEIN from Streptomyces coelicolor (280 aa), FASTA scores: opt: 639, E(): 5.1e-32, (46.3% identity in 285 aa overlap); and similar to other proteins e.g. Q9F641|MXCB protein of the biosynthetic gene cluster of the myxochelin-type iron chelator from Stigmatella aurantiaca (270 aa), FASTA scores: opt: 417, E(): 2.2e-18, (34.2% identity in 263 aa overlap); Q56646|VIUB_VIBCH|VC2210 VIBRIOBACTIN UTILIZATION PROTEIN from Vibrio cholerae (271 aa), FASTA scores: opt: 395, E(): 5.1e-17, (31.0% identity in 274 aa overlap); Q56743|VIUB_VIBVU VULNIBACTIN UTILIZATION PROTEIN V from Vibrio vulnificus (271 aa), FASTA scores: opt: 390, E(): 1e-16, (33.95% identity in 274 aa overlap); etc. Equivalent to AAK47289 from Mycobacterium tuberculosis strain CDC1551 (321 aa) but shorter 38 aa.; mycobactin utilization protein ViuB	complement(3204381..3205232)	Mycobacterium tuberculosis H37Rv	888180
NP_217412.1	CDS	Rv2896c	NC_000962.2	3205265	3206434	R	Rv2896c, (MTCY274.27c), len: 389 aa. Conserved hypothetical protein, similar to others proteins e.g. Q9ZJ08|FIR2 from Rhodococcus fascians (293 aa), FASTA scores: opt: 663, E(): 3.3e-32, (43.7% identity in 286 aa overlap); O69892|SC2E1.21 HYPOTHETICAL 37.9 KDA PROTEIN from Streptomyces coelicolor (382 aa), FASTA scores: opt: 600, E(): 2.2e-28, (46.45% identity in 267 aa overlap); Q9JWZ4|DPRA|NMA0158 DPRA HOMOLOG from Neisseria meningitidis (serogroup A) (395 aa), FASTA scores: opt: 495, E(): 4.1e-22, (34.6% identity in 347 aa overlap); etc.; hypothetical protein	complement(3205265..3206434)	Mycobacterium tuberculosis H37Rv	887177
NP_217413.1	CDS	Rv2897c	NC_000962.2	3206431	3207942	R	Rv2897c, (MTCY274.28c), len: 503 aa. Conserved hypothetical protein, possibly Mg-chelatase, highly similar to hypothetical proteins and chelatases e.g. Q9RTV0|DR1656 MG(2+) CHELATASE FAMILY PROTEIN from Deinococcus radiodurans (519 aa), FASTA scores: opt: 1333, E(): 3.6e-68, (46.55% identity in 505 aa overlap);Q55372|SLR0904 HYPOTHETICAL 55.1 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (509 aa), FASTA scores: opt: 1271, E(): 1.2e-64, (42.65% identity in 504 aa overlap); Q9HTR4|PA5290 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (497 aa), FASTA scores: opt: 1248, E(): 2.3e-63, (45.9% identity in 503 aa overlap); Q9K0Z6|COMM|NMB0405 COMPETENCE PROTEIN (MG-CHELATASE) from Neisseria meningitidis (serogroup B), FASTA scores: opt: 1229, E(): 2.8e-62, (43.2% identity in 509 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	complement(3206431..3207942)	Mycobacterium tuberculosis H37Rv	888212
NP_217414.1	CDS	Rv2898c	NC_000962.2	3207942	3208328	R	Rv2898c, (MTCY274.29c), len: 128 aa. Conserved hypothetical protein, highly similar to O33024|YS98_MYCLE|ML1607|MLCB250.49 HYPOTHETICAL 11.0 KDA PROTEIN from Mycobacterium leprae (96 aa), FASTA scores: opt: 318, E(): 2.3e-16, (58.35% identity in 96 aa overlap). Also similar to other hypothetical proteins e.g. O69890|YE19_STRCO|SC2E1.19 from Streptomyces coelicolor (130 aa), FASTA scores: opt: 253, E(): 1.7e-11, (39.65% identity in 121 aa overlap); Q9HVZ1|PA4424 from Pseudomonas aeruginosa (125 aa), FASTA scores: opt: 234, E(): 4.2e-10, (40.85% identity in 115 aa overlap); O86871 from Streptomyces lividans (85 aa), FASTA scores: opt: 224, E(): 1.8e-09, (46.45% identity in 84 aa overlap); etc. Equivalent to AAK47292 from Mycobacterium tuberculosis strain CDC1551 (141 aa) but shorter 13 aa.; hypothetical protein	complement(3207942..3208328)	Mycobacterium tuberculosis H37Rv	888507
NP_217415.1	CDS	fdhD	NC_000962.2	3208576	3209406	R	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein	complement(3208576..3209406)	Mycobacterium tuberculosis H37Rv	888201
NP_217416.1	CDS	fdhF	NC_000962.2	3209406	3211745	R	Rv2900c, (MTCY274.31c), len: 779 aa. Possible fdhF, formate dehydrogenase (EC 1.2.1.2), highly similar to others formate dehydrogenases and prokaryotic molybdopterin-containing oxidoreductases e.g. Q9S2J9|SC7H2.18 PUTATIVE FORMATE DEHYDROGENASE from Streptomyces coelicolor (759 aa), FASTA scores: opt: 3038, E(): 2.7e-180, (59.7% identity in 767 aa overlap); Q9HU08|PA5181 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (773 aa), FASTA scores: opt: 2560, E(): 1.1e-150, (53.2% identity in 761 aa overlap); P78160 FORMATE DEHYDROGENASE A CHAIN (EC 1.2.1.2) (FRAGMENT) from Escherichia coli strain K12 (740 aa), FASTA scores: opt: 2002, E(): 3.7e-116, (43.1% identity in 733 aa overlap); P07658|FDHF_ECOLI|P78137|B4079 FORMATE DEHYDROGENASE from Escherichia coli strain K12 (715 aa), FASTA scores: opt: 305, E(): 5.6e-13, (25.5% identity in 748 aa overlap); etc. BELONGS TO THE PROKARYOTIC MOLYBDOPTERIN-CONTAINING OXIDOREDUCTASE FAMILY.; formate dehydrogenase H	complement(3209406..3211745)	Mycobacterium tuberculosis H37Rv	887987
NP_217417.1	CDS	Rv2901c	NC_000962.2	3211803	3212108	R	Rv2901c, (MTCY274.32c), len: 101 aa. Conserved hypothetical protein, very equivalent to O33023|ML1610|MLCB250.41 HYPOTHETICAL 12.3 KDA PROTEIN from Mycobacterium leprae (101 aa), FASTA scores: opt: 658, E(): 2.6e-43, (99.0% identity in 101 aa overlap). Also highly similar to O69889|SC2E1.18 HYPOTHETICAL PROTEIN from Streptomyces coelicolor and Streptomyces lividans (102 aa), FASTA scores: opt: 515, E(): 2.2e-32, (75.0% identity in 100 aa overlap).; hypothetical protein	complement(3211803..3212108)	Mycobacterium tuberculosis H37Rv	888605
NP_217418.1	CDS	rnhB	NC_000962.2	3212162	3212956	R	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII	complement(3212162..3212956)	Mycobacterium tuberculosis H37Rv	888504
NP_217419.1	CDS	lepB	NC_000962.2	3212970	3213854	R	Rv2903c, (MTCY274.34c), len: 294 aa. Probable lepB, signal peptidase I (EC 3.4.21.89) (TYPE II MEMBRANE PROTEIN) (see Braunstein & Belisle 2000), equivalent to O33021|LEP_MYCLE|ML1612|MLCB250.39 PROBABLE SIGNAL PEPTIDASE I from Mycobacterium leprae (289 aa), FASTA scores: opt: 1335, E(): 1.8e-77, (69.75% identity in 301 aa overlap). Also similar to many e.g. O86869|SIPX SIGNAL PEPTIDASE I from Streptomyces lividans (320 aa), FASTA scores: opt: 474, E(): 1e-22, (43.55% identity in 248 aa overlap); O69884|SIP1|SIPW PUTATIVE SIGNAL PEPTIDASE I from Streptomyces coelicolor and Streptomyces lividans (259 aa), FASTA scores: opt: 226, E(): 5e-07, (36.0% identity in 214 aa overlap); P42668|LEP_BACLI|SIP SIGNAL PEPTIDASE I from Bacillus licheniformis (186 aa), FASTA scores: opt: 218, E(): 1.3e-06, (34.5% identity in 194 aa overlap); etc. Contains PS00501 Signal peptidases I serine active site,and PS00761 Signal peptidases I signature 3. BELONGS TO PEPTIDASE FAMILY S26; ALSO KNOWN AS TYPE I LEADER PEPTIDASE FAMILY.; signal peptidase I LepB	complement(3212970..3213854)	Mycobacterium tuberculosis H37Rv	887157
NP_217420.1	CDS	rplS	NC_000962.2	3213912	3214253	R	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19	complement(3213912..3214253)	Mycobacterium tuberculosis H37Rv	887356
NP_217421.1	CDS	lppW	NC_000962.2	3214628	3215572	D	Rv2905, (MTCY274.36), len: 314 aa. Probable lppW, conserved ala-rich lipoprotein, with slight similarity to beta-lactamases and hypothetical proteins e.g. Q9S1P7|SCJ9A.23 HYPOTHETICAL 36.3 KDA PROTEIN from Streptomyces coelicolor (336 aa), FASTA scores: opt: 222, E(): 2.8e-06, (25.5% identity in 298 aa overlap); O69914|SC3C8.01 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (302 aa), FASTA scores: opt: 201, E(): 5.1e-05, (24.9% identity in 257 aa overlap); P14559|BLAC_STRAL BETA-LACTAMASE PRECURSOR from Streptomyces albus G (314 aa), FASTA scores: opt: 113, E(): 3.3, (25.2% identity in 278 aa overlap); etc. Has signal peptide and appropriately positioned prokaryotic lipoprotein lipid attachment site: ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR (POTENTIAL).; alanine rich lipoprotein LppW	3214628..3215572	Mycobacterium tuberculosis H37Rv	887421
NP_217422.1	CDS	trmD	NC_000962.2	3215665	3216357	R	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase	complement(3215665..3216357)	Mycobacterium tuberculosis H37Rv	888495
NP_217423.1	CDS	rimM	NC_000962.2	3216361	3216891	R	Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM	complement(3216361..3216891)	Mycobacterium tuberculosis H37Rv	887188
NP_217424.1	CDS	Rv2908c	NC_000962.2	3216905	3217147	R	Rv2908c, (MTCY274.40c), len: 80 aa. Conserved hypothetical protein, equivalent to O33015|YT08_MYCLE from Mycobacterium leprae (80 aa), FASTA scores: opt: 492, E(): 3.1e-29, (93.75% identity in 80 aa overlap). Also highly similar to others e.g. O69880|YE09_STRCO from Streptomyces coelicolor (79 aa), FASTA scores: opt: 356, E(): 3e-19, (71.6% identity in 74 aa overlap); Q9KA12|BH2482 PROTEIN from Bacillus halodurans (76 aa), FASTA scores: opt: 220, E(): 2.9e-09, (48.6% identity in 72 aa overlap); O31738|YLQC_BACSU HYPOTHETICAL 9.1 KDA PROTEIN from Bacillus subtilis (81 aa), FASTA scores: opt: 172, E(): 1e-05, (39.2% identity in 74 aa overlap); etc. BELONGS TO THE UPF0109 FAMILY.; hypothetical protein	complement(3216905..3217147)	Mycobacterium tuberculosis H37Rv	887336
NP_217425.1	CDS	rpsP	NC_000962.2	3217155	3217643	R	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16	complement(3217155..3217643)	Mycobacterium tuberculosis H37Rv	888631
NP_217426.1	CDS	Rv2910c	NC_000962.2	3217827	3218270	R	Rv2910c, (MTCY274.42c), len: 147 aa. Conserved hypothetical protein, showing some similarity with hypothetical proteins from other organisms e.g. Q9JN76|MMYY HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 164, E(): 0.00026, (35.05% identity in 129 aa overlap); etc. Also some similarity with protein from Mycobacterium tuberculosis e.g. O07237|Rv0310c|MTCY63.15c (163 aa), FASTA scores: opt: 165, E(): 0.00023, (26.3% identity in 137 aa overlap); P96815|Rv0138|MTCI5.12 (167 aa), FASTA scores: opt: 132, E(): 0.048, (30.25% identity in 109 aa overlap); etc.; hypothetical protein	complement(3217827..3218270)	Mycobacterium tuberculosis H37Rv	887387
YP_177914.1	CDS	dacB2	NC_000962.2	3218339	3219214	D	Rv2911, (MTCY274.43), len: 291 aa. Probable dacB2, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) (EC 3.4.16.4), an ala-rich protein. Highly similar (except in N-terminus) to Q9CCM2|ML0691 PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Mycobacterium leprae (411 aa), FASTA scores: opt: 749, E(): 9.3e-39, (46.75% identity in 276 aa overlap). Also similar to penicillin binding proteins / D-alanyl-D-alanine carboxypeptidases e.g. Q9KCJ8|SC4G1.16c D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Streptomyces coelicolor (382 aa), FASTA scores: opt: 386, E(): 2.1e-16, (31.25% identity in 285 aa overlap); P35150|DACB_BACSU PENICILLIN-BINDING PROTEIN 5* PRECURSOR from Bacillus subtilis (382 aa), FASTA scores: opt: 384, E(): 3.6e-17, (30.7% identity in 244 aa overlap); Q9K8X5|DACB|BH2877 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (PENICILLIN-BINDING PROTEIN 5) from Bacillus halodurans (395 aa), FASTA scores: opt: 359, E(): 9.7e-15, (30.3% identity in 241 aa overlap); P33364|PBP7_ECOLI|PBPG|B2134 penicillin-binding protein 7 precursor from Escherichia coli strain K12 (313 aa), FASTA scores: opt: 273, E(): 7.5e-10, (27.8% identity in 263 aa overlap); etc. Also similar to O53380|Rv3330|MTV016.30 PENICILLIN-BINDING PROTEIN from Mycobacterium tuberculosis (405 aa), FASTA scores: opt: 746, E(): 1.4e-38, (47.0% identity in 266 aa overlap). Seems to contain PF00768 Peptidase_S11 domain PFAM. BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY. Thought to be a membrane-bound protein. Note that previously known as dacB.; dacB; D-alanyl-D-alanine carboxypeptidase	3218339..3219214	Mycobacterium tuberculosis H37Rv	887189
NP_217428.1	CDS	Rv2912c	NC_000962.2	3219274	3219861	R	Rv2912c, (MTCY274.44c), len: 195 aa. Probable transcription regulatory protein, tetR family, showing similarity with others e.g. Q9K3V9|SCD10.17 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (202 aa), FASTA scores: opt: 185, E(): 4.4e-05, (31.15% identity in 167 aa overlap); Q9KFQ0 TETR-FAMILY from Bacillus halodurans (185 aa), FASTA scores: opt: 164, E(): 0.001, (35.6% identity in 73 aa overlap); P17446|BETI_ECOLI|BETI|B0313 regulatory protein from Escherichia coli strain K12 (195 aa), FASTA scores: opt: 126, E(): 0.024, (24.5% identity in 196 aa overlap); etc. Contains possible helix-turn-helix motif at aa 33-54 (+2.71 SD). POSSIBLY BELONGS TO THE TETR/ACRR FAMILY.; TetR family transcriptional regulator	complement(3219274..3219861)	Mycobacterium tuberculosis H37Rv	888017
NP_217429.1	CDS	Rv2913c	NC_000962.2	3219863	3221698	R	Rv2913c, (MTCY338.01c, MTCY274.45c), len: 611 aa. Possible D-amino acid aminohydrolase (EC 3.5.1.-), similar (principally in N-terminus) to D-amino acid aminohydrolases e.g. Q9V2D3|NDAD|PAB0090 D-AMINOACYLASE (ASPARTATE, GLUTAMATE ETC) from Pyrococcus abyssi (526 aa), FASTA scores: opt: 336, E(): 2.2e-13, (27.55% identity in 581 aa overlap); P94212|NDDD_ALCXX N-ACYL-D-ASPARTATE DEACYLASE (EC 3.5.1.83) (N-ACYL-D-ASPARTATE AMIDOHYDROLASE) from Alcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans) (498 aa), FASTA scores: opt: 221, E(): 3.4e-06, (25.95% identity in 532 aa overlap); Q9AGH8 D-AMINOACYLASE (EC 3.5.1.81) from Alcaligenes faecalis (484 aa), FASTA scores: opt: 218, E(): 5.1e-06, (28.35% identity in 434 aa overlap); etc.; D-amino acid aminohydrolase	complement(3219863..3221698)	Mycobacterium tuberculosis H37Rv	887809
NP_217430.1	CDS	pknI	NC_000962.2	3221767	3223524	R	Rv2914c, (MTCY338.02c), len: 585 aa. Probable pknI, transmembrane serine/threonine-protein kinase (EC 2.7.1.-) (see citation below), ala-rich protein, highly similar to many in Mycobacterium tuberculosis and other bacteria e.g. Q9RLQ7|MBK PUTATIVE SERINE/THREONINE PROTEIN KINASE from Mycobacterium bovis BCG (291 aa), FASTA scores: opt: 376, E(): 1.1e-10, (36.95% identity in 287 aa overlap); P33973|PKN1_MYXXA serine/threonine-protein kinase from Myxococcus xanthus (693 aa), FASTA scores: opt: 286, E(): 5.4e-10, (29.9% identity in 374 aa overlap); P72003|PKNF_MYCTU|Rv1746|MT1788|MTCY28.09 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium tuberculosis (476 aa), FASTA scores: opt: 675, E(): 1.7e-24, (39.75% identity in 468 aa overlap); Q10697|PKNJ_MYCTU|Rv2088|MT2149|MTCY49.28 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium tuberculosis (589 aa), FASTA scores: opt: 574, E(): 1e-19, (34.85% identity in 479 aa overlap); etc. Equivalent to AAK47308 from Mycobacterium tuberculosis strain CDC1551 (603 aa) but shorter 18 aa. Contains Hank's kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.; transmembrane serine/threonine-protein kinase I	complement(3221767..3223524)	Mycobacterium tuberculosis H37Rv	887642
NP_217431.1	CDS	Rv2915c	NC_000962.2	3223568	3224680	R	Rv2915c, (MTCY338.03c), len: 370 aa. Conserved hypothetical protein, posssibly XAA-PRO dipeptidase (prolidase) (EC 3.4.13.9), highly similar to CAC38796|SCI39.08c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (363 aa), FASTA scores: opt: 1341, E(): 5.5e-76, (56.65% identity in 362 aa overlap); and similar to prolidases (XAA-PRO dipeptidase) e.g. Q9ABC9|CC0300 PUTATIVE XAA-PRO DIPEPTIDASE from Caulobacter crescentus (428 aa), FASTA scores: opt: 327, E(): 7.4e-13, (30.2% identity in 374 aa overlap); Q97XD4 PROLIDASE from Sulfolobus solfataricus (396 aa), FASTA scores: opt: 271, E(): 2.1e-09, (30.5% identity in 354 aa overlap); Q9WX55 PROLIDASE from Microbacterium esteraromaticum (393 aa), FASTA scores: opt: 256, E(): 1.8e-08, (27.95% identity in 365 aa overlap); etc. Also similar to O53619|Rv0074|MTV030.18 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (411 aa), FASTA scores: opt: 243, E(): 1.2e-07, (27.5% identity in 389 aa overlap).; hypothetical protein	complement(3223568..3224680)	Mycobacterium tuberculosis H37Rv	888083
NP_217432.1	CDS	ffh	NC_000962.2	3224708	3226285	R	Rv2916c, (MTCY338.04c), len: 525 aa. Probable ffh, signal recognition particle (SRP) protein (ala-, gly-, leu-rich protein) (see citation below), equivalent to O33013|SR54_MYCLE SIGNAL RECOGNITION PARTICLE from Mycobacterium leprae (521 aa), FASTA scores: opt: 2968, E(): 1.6e-145, (87.85% identity in 526 aa overlap). Also highly similar to others e.g. O69874|FFH from Streptomyces coelicolor (550 aa), FASTA scores: opt: 2025, E(): 6e-97, (63.8% identity in 519 aa overlap) (N-terminus longer 34 aa); P37105|SR54_BACSU from Bacillus subtilis (446 aa), FASTA scores: opt: 1451, E(): 1.9e-67, (51.5% identity in 435 aa overlap); BAB57399|FFH from Staphylococcus aureus subsp. aureus Mu50 (455 aa), FASTA scores: opt: 1418, E(): 9.4e-66, (48.65% identity in 448 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SRP FAMILY OF GTP-BINDING PROTEINS. NOTE THAT SIGNAL RECOGNITION PARTICLE CONSISTS OF A SMALL CYTOPLASMIC RNA (SC-RNA) MOLECULE AND PROTEIN FFH. THE PROTEIN HAS A TWO DOMAIN STRUCTURE: THE G-DOMAIN BINDS GTP; THE M-DOMAIN BINDS THE RNA AND ALSO BINDS THE SIGNAL SEQUENCE.; signal recognition particle protein	complement(3224708..3226285)	Mycobacterium tuberculosis H37Rv	888242
NP_217433.1	CDS	Rv2917	NC_000962.2	3226363	3228243	D	Rv2917, (MTCY338.05), len: 626 aa. Conserved hypothetical ala-, arg-rich protein, highly similar (but longer 34 aa) to O33011|ML1624|MLCB250.18C HYPOTHETICAL 65.2 KDA PROTEIN from Mycobacterium leprae (596 aa), FASTA scores: opt: 3117, E(): 9e-183, (79.8% identity in 584 aa overlap). Also highly similar to Q9S2E8|SCE19A.36C HYPOTHETICAL 66.2 KDA PROTEIN from Streptomyces coelicolor (598 aa), FASTA scores: opt: 1921, E(): 1.1e-109, (56.08% identity in 567 aa overlap); and Q9S3Y6|SDRA SDRA PROTEIN from Streptomyces coelicolor (597 aa), FASTA scores: opt: 1896, E(): 3.6e-108, (55.75% identity in 567 aa overlap). And shows some similarity with others proteins from other organisms. Equivalent to AAK47311 putative RNA helicase from Mycobacterium tuberculosis strain CDC1551 (602 aa) but longer 24 aa. Contains PS00017 ATP/GTP-binding site motif (P-loop).; hypothetical protein	3226363..3228243	Mycobacterium tuberculosis H37Rv	887758
NP_217434.1	CDS	glnD	NC_000962.2	3228254	3230680	R	catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK; PII uridylyl-transferase	complement(3228254..3230680)	Mycobacterium tuberculosis H37Rv	888621
NP_217435.1	CDS	glnB	NC_000962.2	3230738	3231076	R	Rv2919c, (MTCY338.08c), len: 112 aa. Probable glnB, nitrogen regulatory protein, highly similar to others e.g. Q9X705|GLNB PII PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (112 aa), FASTA scores: opt: 531, E(): 4.5e-30, (68.75% identity in 112 aa overlap); P21193|GLNB_AZOBR NITROGEN REGULATORY PROTEIN P-II from Azospirillum brasilense (112 aa), FASTA scores: opt: 496, E(): 1.2e-27, (60.7% identity in 112 aa overlap); P05826|GLNB_ECOLI|B2553|Z3829|ECS3419|STY2808 NITROGEN REGULATORY PROTEIN P-II from Escherichia coli strains K12 and O157:H7 (112 aa), FASTA scores: opt: 487, E(): 5.3e-27, (61.6% identity in 112 aa overlap); etc. Contains PS00496 P-II protein urydylation site. BELONGS TO THE P(II) PROTEIN FAMILY.; nitrogen regulatory protein P-II GLNB	complement(3230738..3231076)	Mycobacterium tuberculosis H37Rv	887756
NP_217436.1	CDS	amt	NC_000962.2	3231073	3232506	R	Rv2920c, (MTCY338.09c), len: 477 aa. Probable amt, ammonium-transport integral membrane protein (ala-, gly-, leu-, val-rich protein), highly similar to others e.g. Q9ZBP6|SC7A1.27 AMMONIUM TRANSPORTER from Streptomyces coelicolor (448 aa), FASTA scores: opt: 1246, E(): 7.3e-67, (54.1% identity in 462 aa overlap); P54146|AMT_CORGL AMMONIUM TRANSPORT SYSTEM from Corynebacterium glutamicum (452 aa), FASTA scores: opt: 953, E(): 2.1e-49, (41.45% identity in 475 aa overlap); Q07429|NRGA_BACSU PROBABLE AMMONIUM TRANSPORTER (MEMBRANE PROTEIN NRGA) from Bacillus subtilis (404 aa), FASTA scores: opt: 721, E(): 0, (44.4% identity in 430 aa overlap); etc. BELONGS TO THE AMT1/MEP/NRGA FAMILY OF AMMONIUM TRANSPORTERS (TC 2.49).; ammonium transporter	complement(3231073..3232506)	Mycobacterium tuberculosis H37Rv	887683
NP_217437.1	CDS	ftsY	NC_000962.2	3232871	3234139	R	Rv2921c, (MTCY338.10c, MT2989), len: 422 aa. Probable ftsY, signal recognition particle (SRP) receptor, a membrane-associated cell division protein (see citation below), equivalent to O33010|FTSY_MYCLE CELL DIVISION PROTEIN FTSY HOMOLOG from Mycobacterium leprae (430 aa), FASTA scores: opt: 1760, E(): 1.1e-108, (81.35% identity in 429 aa overlap). Also similar to others e.g. Q9I6C1|FTSY|PA0373 SIGNAL RECOGNITION PARTICLE RECEPTOR FTSY from Pseudomonas aeruginosa (455 aa), FASTA scores: opt: 882, E(): 5.1e-40, (42.08% identity in 385 aa overlap); Q9KVJ6|FTSY CELL DIVISION PROTEIN from Vibrio cholerae (391 aa), FASTA scores: opt: 837, E(): 1.2e-37, (36.3% identity in 394 aa overlap); P10121|FTSY_ECOLI|FTSY|B3464 CELL DIVISION PROTEIN from Escherichia coli strain K12 (497 aa), FASTA scores: opt: 800, E(): 1.3e-35, (39.75% identity in 327 aa overlap); etc. Also similar to Q9ZBP9|SC7A1.24 PUTATIVE PROKARYOTIC DOCKING PROTEIN from Streptomyces coelicolor (412 aa), FASTA scores: opt: 1461, E(): 4.3e-71, (60.3% identity in 423 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00300 SRP54-type proteins GTP-binding domain signature. BELONGS TO THE SRP FAMILY OF GTP-BINDING PROTEINS.; cell division protein FtsY	complement(3232871..3234139)	Mycobacterium tuberculosis H37Rv	887205
NP_217438.2	CDS	smc	NC_000962.2	3234189	3237806	R	Rv2922c, (MT2990, MTCY338.11c), len: 1205 aa. Probable smc, chromosome partition protein (ala-, arg-, leu-, glu-rich protein, possibly coiled-coil protein) (see * below), equivalent (but longer 84 aa) to Q9CBT5|SMC|ML1629|MLCB250.01 POSSIBLE CELL DIVISION PROTEIN from Mycobacterium leprae (1203 aa), FASTA scores: opt: 5957, E(): 0, (79.15% identity in 1205 aa overlap). Also highly similar to other chromosome segregation proteins e.g. Q9ZBQ2|SC7A1.21 PUTATIVE CHROMOSOME ASSOCIATED PROTEIN from Streptomyces coelicolor (1186 aa), FASTA scores: opt: 2633, E(): 4.1e-120, (53.03% identity in 1205 aa overlap); P51834|SMC_BACSU CHROMOSOME PARTITION PROTEIN from Bacillus subtilis (1186 aa), FASTA scores: opt: 1009, E(): 2.1e-41, (30.75% identity in 1205 aa overlap); Q9CHC9|SMC CHROMOSOME SEGREGATION PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (924 aa), FASTA scores: opt: 996, E(): 7.5e-41, (29.75% identity in 874 aa overlap); etc. Equivalent to AAK47317 from Mycobacterium tuberculosis strain CDC1551 (1205 aa) but longer 84 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE SMC FAMILY. N-terminus shortened since first submission. [* Note: Unpublished. Cobbe N., Heck M.M.S.- Phylogenetic analysis of SMC proteins (OCT-2001)].; chromosome partition protein Smc	complement(3234189..3237806)	Mycobacterium tuberculosis H37Rv	887179
YP_177679.1	CDS	acyP	NC_000962.2	3237818	3238099	R	catalyzes the hydrolysis of acylphosphate; acylphosphatase	complement(3237818..3238099)	Mycobacterium tuberculosis H37Rv	3205043
NP_217439.1	CDS	Rv2923c	NC_000962.2	3238086	3238499	R	Rv2923c, (MTCY338.12c), len: 137 aa. Conserved hypothetical protein, showing similarity with other hypothetical proteins e.g. P24246|YHFA_ECOLI|B3356|Z4717|ECS4207 from Escherichia coli strains K12 and O157:H7 (134 aa), FASTA scores: opt: 110, E(): 1.9, (25.9% identity in 135 aa overlap); etc.; hypothetical protein	complement(3238086..3238499)	Mycobacterium tuberculosis H37Rv	887687
NP_217440.1	CDS	fpg	NC_000962.2	3238601	3239470	R	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase	complement(3238601..3239470)	Mycobacterium tuberculosis H37Rv	887438
NP_217441.1	CDS	rnc	NC_000962.2	3239829	3240551	R	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III	complement(3239829..3240551)	Mycobacterium tuberculosis H37Rv	887873
NP_217442.1	CDS	Rv2926c	NC_000962.2	3240548	3241171	R	Rv2926c, (MTCY338.15c), len: 207 aa. Conserved hypothetical protein, equivalent to O69468|ML1660|MLCB1243.14 HYPOTHETICAL 23.5 KDA PROTEIN from Mycobacterium leprae (217 aa), FASTA scores: opt: 866, E(): 1.4e-48, (67.2% identity in 192 aa overlap). Also similar in part to other hypothetical proteins e.g. Q9WXZ8 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (182 aa), FASTA scores: opt: 254, E(): 3.4e-09, (31.45% identity in 143 aa overlap); Q9ZBQ9|SC7A1.14 HYPOTHETICAL 23.5 KDA PROTEIN from Streptomyces coelicolor (217 aa), FASTA scores: opt: 244, E(): 1.7e-08, (45.5% identity in 189 aa overlap); O65982 HYPOTHETICAL 26.2 KDA PROTEIN from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (228 aa), FASTA scores: opt: 220, E(): 6.1e-07, (32.45% identity in 148 aa overlap); etc. Equivalent to AAK47323 from Mycobacterium tuberculosis strain CDC1551 (195 aa) but longer 12 aa.; hypothetical protein	complement(3240548..3241171)	Mycobacterium tuberculosis H37Rv	887487
NP_217443.1	CDS	Rv2927c	NC_000962.2	3241222	3241959	R	Rv2927c, (MTCY338.16c), len: 245 aa. Conserved hypothetical protein, equivalent to Q9CBS6|ML1661|MLCB1243.13 (alias O69467) HYPOTHETICAL PROTEIN from Mycobacterium leprae (247 aa), FASTA scores: opt: 1440, E(): 4.9e-76, (90.6% identity in 245 aa overlap). Also similar to many hypothetical proteins from other organisms e.g. Q9ZBR0|SC7A1.13 HYPOTHETICAL 41.0 KDA PROTEIN from Streptomyces coelicolor (379 aa), FASTA scores: opt: 266, E(): 3.4e-08, (29.9% identity in 234 aa overlap); etc. Also some similarity with P46815|AG84_MYCLE|ML0922 ANTIGEN 84 from Mycobacterium leprae (266 aa), FASTA scores: opt: 193, E(): 0.00043, (28.7% identity in 136 aa overlap) (see citation below); and P46816|AG84_MYCTU|WAG31|Rv2145c|MT2204|MTCY270.23 ANTIGEN 84 from Mycobacterium tuberculosis (260 aa), FASTA scores: opt: 178, E(): 0.0031, (34.35% identity in 131 aa overlap) (see citation below). Contains potential coiled-coil region.; hypothetical protein	complement(3241222..3241959)	Mycobacterium tuberculosis H37Rv	887317
NP_217444.1	CDS	tesA	NC_000962.2	3242198	3242983	D	Rv2928, (MTCY338.17), len: 261 aa. Probable tesA, thioesterase (EC 3.1.2.-), equivalent to Q9Z5K4|ML2359|MLCB12.04c PUTATIVE THIOESTERASE from Mycobacterium leprae (261 aa), FASTA scores: opt: 1326, E(): 3.7e-80, (73.2% identity in 261 aa overlap). Also similar to others e.g. Q9ZGI1 THIOESTERASE II PIKAV from Streptomyces venezuelae (281 aa), FASTA scores: opt: 535, E(): 6.6e-28, (38.05% identity in 234 aa overlap); Q9L4W2|NYSE thioesterase involved in synthesis of the polyene antifungal antibiotic nystatin from Streptomyces noursei (see Brautaset et al., 2000) (251 aa), FASTA scores: opt: 523, E(): 3.8e-27, (34.53% identity in 223 aa overlap); Q54145 THIOESTERASE from Streptomyces fradiae (253 aa), FASTA scores: opt: 495, E(): 2.7e-25, (37.85% identity in 230 aa overlap); etc.; thioesterase TESA	3242198..3242983	Mycobacterium tuberculosis H37Rv	887446
NP_217445.1	CDS	Rv2929	NC_000962.2	3242970	3243281	D	Rv2929, (MTCY338.18), len: 103 aa. Hypothetical unknown protein; unlikely ORF but some weak similarity to C-terminal half of P18319|UREG_KLEAE urease accessory protein from klebsiella aerogenes (205 aa), FASTA scores: opt: 99, E(): 1.1, (38.6% identity in 57 aa overlap).; hypothetical protein	3242970..3243281	Mycobacterium tuberculosis H37Rv	888112
NP_217446.2	CDS	fadD26	NC_000962.2	3243697	3245448	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	3243697..3245448	Mycobacterium tuberculosis H37Rv	887603
NP_217447.1	CDS	ppsA	NC_000962.2	3245445	3251075	D	Rv2931, (MTCY338.20), len: 1876 aa. ppsA, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q9Z5K6|ML2357|MLCB12.02c PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1871 aa), FASTA scores: opt: 7566, E(): 0, (76.1% identity in 1888 aa overlap); Q9S384|ML2356|MLCB12.01c PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1540 aa), FASTA scores: opt: 4026, E(): 9.8e-212, (45.7% identity in 1811 aa overlap); Q49932|PKSC|L518_F1_2 PUTATIVE POLYKETIDE SYNTHASE (1446 aa), FASTA scores: opt: 4026, E(): 9.4e-212, (70.6% identity in 885 aa overlap). Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9L8C7|EPOC POLYKETIDE SYNTHASE from Polyangium cellulosum (7257 aa), FASTA scores: opt: 2592, E(): 5.2e-133, (32.55% identity in 2245 aa overlap); P22367|MSAS_PENPA 6-methylsalicylic acid synthase from Penicillium patulum (Penicillium griseofulvum) (1774 aa), FASTA scores: opt: 2391, E(): 0, (34.2% identity in 1815 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1538 aa), FASTA scores: opt: 4227, E(): 0, (46.8% identity in 1810 aa overlap) (gap in middle); etc. Contains PS00606 Beta-ketoacyl synthases active site, and PS00012 Phosphopantetheine attachment site. Note that Rv2931|ppsA belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).; phenolpthiocerol synthesis type-I polyketide synthase PPSA	3245445..3251075	Mycobacterium tuberculosis H37Rv	888183
NP_217448.1	CDS	ppsB	NC_000962.2	3251072	3255688	D	Rv2932, (MTV011.01, MTCY338.21, MT3002), len 1538 aa. ppsB, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q9S384|ML2356|MLCB12.01c PUTATIVE POLYKETIDE SYNTHASE (1540 aa), FASTA scores: opt: 7284, E(): 0, (76.3% identity in 1561 aa overlap); Q49932|PKSC|L518_F1_2 PUTATIVE POLYKETIDE SYNTHASE (1446 aa), FASTA scores: opt: 6811, E(): 0, (76.2% identity in 1462 aa overlap); etc. Also similar to polyketide synthases from other bacteria e.g. Q9KIZ6|EPOE EPOE PROTEIN from Polyangium cellulosum (3798 aa), FASTA scores: opt: 3052, E(): 3.3e-165, (38.35% identity in 1538 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10977|PPSA_MYCTU|RV2931 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1876 aa), FASTA scores: opt: 4227, E(): 0, (46.9% identity in 1810 aa overlap); P96203|PPSD|Rv2934|MTCY19H9.02 PKSE PROTEIN (1827 aa), FASTA scores: opt: 3756, E(): 1.8e-205, (42.9% identity in 1808 aa overlap); etc. Overlaps and extends CDS from neighbouring cosmid MTCY338.21. Contains PS00606 Beta-ketoacyl synthases active site. Note that Rv2932|ppsB belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).; phenolpthiocerol synthesis type-I polyketide synthase PPSB	3251072..3255688	Mycobacterium tuberculosis H37Rv	888023
NP_217449.1	CDS	ppsC	NC_000962.2	3255685	3262251	D	Rv2933, (MTCY19H9.01, MTV011.02), len: 2188 aa. ppsC, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q49933|PKSD|ML2355|L518_F1_3 PUTATIVE POLYKETIDE SYNTHASE (2201 aa), FASTA scores: opt: 6973, E(): 0, (82.32% identity in 2217 aa overlap); Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC ACID SYNTHASE (2118 aa), FASTA scores: opt: 4015, E(): 2.9e-208, (36.6% identity in 2184 aa overlap); etc. Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9L8C7 POLYKETIDE SYNTHASE from Polyangium cellulosum (7257 aa), FASTA scores: opt: 3909, E(): 3.6e-202, (40.15% identity in 2220 aa overlap); Q9KIZ7|EPOD EPOD PROTEIN from Polyangium cellulosum (7257 aa), FASTA scores: opt: 3886, E(): 6.2e-201, (40.05% identity in 2220 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. P96291|Rv2940c (2111 aa), FASTA scores: opt: 4204, E(): 0, (39.1% identity in 2176 aa overlap); Q10977|PPSA_MYCTU|RV2931 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1876 aa), FASTA scores: opt: 3793, E(): 2.4e-196, (46.65% identity in 1612 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, and PS00012 Phosphopantetheine attachment site. Note that Rv2933|ppsC belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).; phenolpthiocerol synthesis type-I polyketide synthase PPSC	3255685..3262251	Mycobacterium tuberculosis H37Rv	887686
NP_217450.1	CDS	ppsD	NC_000962.2	3262248	3267731	D	Rv2934, (MTCY19H9.02), len: 1827 aa. ppsD, type-I polyketide synthase (see citations below), highly similar to others from Mycobacterium leprae e.g. Q9CB70|ML2354 POLYKETIDE SYNTHASE (1822 aa), FASTA scores: opt: 9779, E(): 0, (80.35% identity in 1836 aa overlap); Q49940|L518_F3_67|PFSE (1815 aa), FASTA scores: opt: 9658, E(): 0, (79.85% identity in 1831 aa overlap); etc. Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9RNB2|MCYD|Q9FDU1 POLYKETIDE SYNTHASE (MCYD PROTEIN) from Microcystis aeruginosa (3906 aa), FASTA scores: opt: 2961, E(): 6e-159, (32.15% identity in 1827 aa overlap); etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE (1538 aa), FASTA scores: opt: 3756, E(): 3.8e-204, (42.85% identity in 1808 aa overlap) (gaps in middle); P96202|PPSC|RV2933 POLYKETIDE SYNTHASE (2188 aa), FASTA scores: opt: 3463, E(): 1.7e-187, (39.2% identity in 2165 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, PS00017 ATP/GTP-binding site motif A, PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and PS00012 Phosphopantetheine attachment site. Note that Rv2934|ppsD belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).; phenolpthiocerol synthesis type-I polyketide synthase PPSD	3262248..3267731	Mycobacterium tuberculosis H37Rv	887172
NP_217451.1	CDS	ppsE	NC_000962.2	3267737	3272203	D	Rv2935, (MTCY19H9.03), len: 1488 aa. ppsE, type-I polyketide synthase (see citations below), equivalent to Q49934|PKSF|ML2353|L518_F1_8 PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1489 aa), FASTA scores: opt: 8156, E(): 0, (82.05% identity in 1493 aa overlap). Also similar to polyketide synthases from other bacteria e.g. Q9RAH3|NOSB NOSB PROTEIN from Nostoc sp. GSV224 (1244 aa), FASTA scores: opt: 2438, E(): 8.8e-137, (43.75% identity in 969 aa overlap); Q9KIZ8|EPOC EPOC PROTEIN from Polyangium cellulosum (1832 aa), FASTA scores: opt: 2272, E(): 8.6e-127, (39.95% identity in 1061 aa overlap); O54155|SC3F7.12 POLYKETIDE SYNTHASE from Streptomyces coelicolor (2297 aa), FASTA scores: opt: 1522, E(): 3.6e-82, (36.35% identity in 1057 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site. Note that Rv2935|ppsE belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).; phenolpthiocerol synthesis type-I polyketide synthase PPSE	3267737..3272203	Mycobacterium tuberculosis H37Rv	888210
NP_217452.1	CDS	drrA	NC_000962.2	3272214	3273209	D	Rv2936, (MTCY19H9.04), len: 331 aa. Probable drrA, daunorubicin-DIM-transport resistance ATP-binding protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below), equivalent to Q49938|DRRA|ML2352|L518_F2_43|DRRA PROBABLE DAUNORUBICIN RESISTANCE ATP-BINDING PROTEIN from Mycobacterium leprae (331 aa), FASTA scores: opt: 1842, E(): 4.2e-103, (85.2% identity in 331 aa overlap). Also highly similar to others e.g. Q9XCF7 DRRA from Mycobacterium avium (315 aa), FASTA scores: opt: 1040, E(): 4.7e-55, (54.35% identity in 309 aa overlap); Q9X5J8 DAUNORUBICIN RESISTANCE PROTEIN A from Mycobacterium avium (315 aa), FASTA scores: opt: 1030, E(): 1.9e-54, (53.7% identity in 309 aa overlap); P32010|DRRA_STRPE DAUNORUBICIN RESISTANCE ATP-BINDING PROTEIN from Streptomyces peucetius (330 aa), FASTA scores: opt: 852, E(): 9e-44, (47.15% identity in 318 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that Rv2936|drrA belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).; daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA	3272214..3273209	Mycobacterium tuberculosis H37Rv	888168
NP_217453.1	CDS	drrB	NC_000962.2	3273206	3274075	D	Rv2937, (MTCY19H9.05), len: 289 aa. Probable drrB, daunorubicin-DIM-transport integral membrane protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below), equivalent to Q49935|DRRB|ML2351|L518_F1_9 DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Mycobacterium leprae (288 aa), FASTA scores: opt: 1252, E(): 5.3e-72, (64.0% identity in 289 aa overlap). Also similar to others e.g. Q9XCF8 DRRB PROTEIN from Mycobacterium avium (246 aa), FASTA scores: opt: 423, E(): 1.5e-19, (30.85% identity in 243 aa overlap); Q9S6H4 DAUNORUBICIN RESISTANCE PROTEIN B from Mycobacterium avium (246 aa), FASTA scores: opt: 420, E(): 2.3e-19, (30.85% identity in 243 aa overlap); P32011|DRRB_STRPE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Streptomyces peucetius (283 aa), FASTA scores: opt: 242, E(): 4.7e-08, (27.85% identity in 219 aa overlap); etc. Note that Rv293|drrB belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).; daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB	3273206..3274075	Mycobacterium tuberculosis H37Rv	887968
NP_217454.1	CDS	drrC	NC_000962.2	3274072	3274902	D	Rv2938, (MTCY19H9.06), len: 276 aa. Probable drrC, daunorubicin-DIM-transport integral membrane protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below), equivalent to Q9CB71|ML2350 PROBABLE ANTIBIOTIC RESISTANCE MEMBRANE PROTEIN from Mycobacterium leprae (276 aa), FASTA scores: opt: 1434, E(): 1.2e-81, (79.0% identity in 276 aa overlap); and Q49941|DRRC|L518_F3_76 PUTATIVE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Mycobacterium leprae (244 aa), FASTA scores: opt: 1194, E(): 8.3e-67, (76.85% identity in 242 aa overlap). Also similar to others e.g. Q9XCF9 DRRC PROTEIN from Mycobacterium avium (263 aa), FASTA scores: opt: 538, E(): 3.7e-26, (32.65% identity in 251 aa overlap); Q9S6H3 DAUNORUBICIN RESISTANCE PROTEIN C from Mycobacterium avium (263 aa), FASTA scores: opt: 533, E(): 7.6e-26, (32.25% identity in 251 aa overlap); P32011|DRRB_STRPE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Streptomyces peucetius (283 aa), FASTA scores: opt: 276, E(): 6.6e-10, (21.07% identity in 261 aa overlap); etc. Note that Rv2938|drrC belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentaly).; daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC	3274072..3274902	Mycobacterium tuberculosis H37Rv	888491
NP_217455.1	CDS	papA5	NC_000962.2	3274949	3276217	D	required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase PapA5	3274949..3276217	Mycobacterium tuberculosis H37Rv	887327
NP_217456.1	CDS	mas	NC_000962.2	3276380	3282715	R	Rv2940c, (MTCY24G1.09, MTCY19H9.08c), len: 2111 aa. Probable mas, mycocerosic acid synthase membrane associated, multifunctional enzyme (see citations below), almost identical to Q02251|MCAS_MYCBO|MAS MYCOCEROSIC ACID SYNTHASE from Mycobacterium bovis (2110 aa), FASTA scores: opt: 13226, E(): 0, (95.8% identity in 2115 aa overlap) (see Mathur & Kolattukudy 1992); and equivalent to Q9CD78|MAS|ML0139 PUTATIVE MYCOCEROSIC SYNTHASE from Mycobacterium leprae (2116 aa), FASTA scores: opt: 12142, E(): 0, (87.95% identity in 2119 aa overlap); and Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC ACID SYNTHASE from Mycobacterium leprae (2118 aa), FASTA scores: opt: 8421, E(): 0, (60.8% identity in 2127 aa overlap). Also similar to other synthases e.g. C-terminus of Q9L8C7|EPOC POLYKETIDE SYNTHASE from Polyangium cellulosum (7257 aa), FASTA scores: opt: 4332, E(): 0, (40.85% identity in 2149 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.01 POLYKETIDE SYNTHASE (2108 aa), FASTA scores: opt: 5059, E(): 0, (65.9% identity in 2121 aa overlap); etc. Contains several domains, organized in the following order: beta-ketoacyl synthase (PS00606), acyl transferase, dehydratase-enoyl reductase, beta-ketoreductase, acyl carrier protein. Contains PS00012 Phosphopantetheine attachment site.; multifunctional mycocerosic acid synthase membrane-associated MAS	complement(3276380..3282715)	Mycobacterium tuberculosis H37Rv	887982
NP_217457.1	CDS	fadD28	NC_000962.2	3283335	3285077	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	3283335..3285077	Mycobacterium tuberculosis H37Rv	887454
NP_217458.1	CDS	mmpL7	NC_000962.2	3285070	3287832	D	Rv2942, (MTCY24G1.07c), len: 920 aa. mmpL7, conserved transmembrane transport protein (see citations below), member of RND superfamily, highly similar to Q9XB10 HYPOTHETICAL 99.5 KDA PROTEIN from Mycobacterium bovis BCG (945 aa), FASTA scores: opt: 488, E(): 4.9e-20, (29.5% identity in 918 aa overlap); and to others from Mycobacteria e.g. O53735|MML4_MYCTU from Mycobacterium tuberculosis (945 aa), FASTA scores: opt: 481, E(): 1.2e-19, (25.9% identity in 922 aa overlap); etc. Also similar to other membrane proteins e.g. O54101|MMLB_STRCO|SC10A5.10c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (847 aa), FASTA scores: opt: 256, E(): 7.2e-07, (25.15% identity in 545 aa overlap); etc. Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site, PS00079 Multicopper oxidases signature 1, and PS00044 Bacterial regulatory proteins, lysR family signature. BELONGS TO THE MMPL FAMILY. Note that Rv2941|fadD28 and Rv2942|mmpL7 are transcriptionally coupled (proven experimentaly).; transmembrane transport protein MmpL7	3285070..3287832	Mycobacterium tuberculosis H37Rv	887548
NP_217459.1	CDS	Rv2943	NC_000962.2	3288464	3289705	D	Rv2943, (MTCY24G1.06c), len: 413 aa. Probable transposase for insertion sequence IS1533, similar to other transposases e.g. P15025|ISTA_ECOLI ista protein (insertion sequence IS21) from Escherichia coli (390 aa), FASTA scores: opt: 268, E(): 5.1e-11, (24.1% identity in 378 aa overlap). Contains potential helix-turn-helix motif at aa 19-40 (Score 1611, +4.67 SD).; IS1533 transposase	3288464..3289705	Mycobacterium tuberculosis H37Rv	887834
YP_177680.1	CDS	Rv2943A	NC_000962.2	3289705	3290235	D	Rv2943A, len: 176 aa. Possible transposase, similar to many e.g. AJ238712|MBO238712_2 PUTATIVE TRANSPOSASE (IS21-l) from Mycobacterium bovis BCG (266 aa), FASTA scores: opt: 762, E(): 0, (100.0% identity in 118 aa overlap). Possible frameshift after codon 118 i.e. near position 3290056, to fuse with Rv2944.; transposase	3289705..3290235	Mycobacterium tuberculosis H37Rv	3205061
NP_217460.1	CDS	Rv2944	NC_000962.2	3289790	3290506	D	Rv2944, (MTCY24G1.05c), len: 238 aa. Possible transposase for IS1533, similar to IS-element proteins e.g. P15026|ISTB_ECOLI istb protein from Escherichia coli (265 aa), FASTA scores: opt: 475, E (): 1.6e-21, (48.0% identity in 148 aa overlap); Z95436|MTY15C10_14 from Mycobacterium tuberculosis (248 aa), FASTA scores: opt: 784, E(): 0, (87.4% identity in 135 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; IS1533 transposase	3289790..3290506	Mycobacterium tuberculosis H37Rv	887636
NP_217461.1	CDS	lppX	NC_000962.2	3290624	3291325	R	Rv2945c, (MTCY24G1.04), len: 233 aa. Probable lppX, conserved lipoprotein, equivalent to Q9CD80 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (233 aa), FASTA scores: opt: 1165, E(): 2.1e-65, (76.4% identity in 233 aa overlap); and similar to Q9CCP6|ML0557 from Mycobacterium leprae (238 aa), FASTA scores: opt: 338, E(): 7.4e-14, (30.75% identity in 231 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. P71679|LPRG_MYCTU LIPOPROTEIN (236 aa), FASTA scores: opt: 342, E(): 4.1e-14, (32.05% identity in 231 aa overlap); etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and has in its N-terminal a signal peptide. BELONGS TO THE LPPX/LPRAFG FAMILY OF LIPOPROTEINS.; lipoprotein LppX	complement(3290624..3291325)	Mycobacterium tuberculosis H37Rv	887956
NP_217462.1	CDS	pks1	NC_000962.2	3291503	3296353	R	Rv2946c, (MTCY24G1.03), len: 1616 aa. Probable pks1, polyketide synthase, similar to many e.g. ML035|AL583917|Q9CD81 putative polyketide synthase from Mycobacterium leprae (2103 aa), Fasta scores: opt: 8761, E(): 0, (82.6% identity in 1620 aa overlap); etc. Almost identical in part to G560507|Q50470 PKS002C protein from Mycobacterium tuberculosis (fragment) (950 aa), Fasta scores: opt: 5685, E(): 0, (95.3% identity in 927 aa overlap). Also similar to Mycobacterium tuberculosis polyketide synthases pks7|Rv1661|P94996 (2126 aa) (54.6% identity in 1632 aa); pks12|Rv2048c|O53490 (4151 aa) (58.0% identity in 1606 aa); pks8|rv1662|O65933 (1602 aa) (59.7% identity in 1144 aa). Contains a PS00012 Phosphopantetheine attachment site.; polyketide synthase PKS1	complement(3291503..3296353)	Mycobacterium tuberculosis H37Rv	888122
NP_217463.1	CDS	pks15	NC_000962.2	3296350	3297840	R	Rv2947c, (MTCY24G1.02), len: 496 aa. Probable pks15, polyketide synthase. Almost identical to G560508|Q50469 PKS002B protein from Mycobacterium tuberculosis (495 aa), FASTA scores: opt: 3270, E(): 0, (99.6% identity in 496 a a overlap). Similar to Mycobacterium tuberculosis proteins MTCY338.20|RV2931|PPSA_MYCTU ppsA phenolpthiocerol synthesis (1876 aa) (49.9% identity in 465 aa overlap); MTCY24G1.09|RV2940C|P96291 Putative mas, mycocerosic acid synthase (2111 aa) (50.2% identity in 454 aa overlap); and MTCY22H8.03|RV2382C|P71718 hypothetical protein (444 aa) (47.6% identity in 437 aa overlap). Contains PS00606 Beta-ketoacyl synthases active site.; polyketide synthase PKS15	complement(3296350..3297840)	Mycobacterium tuberculosis H37Rv	887291
NP_217464.1	CDS	fadD22	NC_000962.2	3297837	3299954	R	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	complement(3297837..3299954)	Mycobacterium tuberculosis H37Rv	887295
NP_217465.1	CDS	Rv2949c	NC_000962.2	3299971	3300570	R	Rv2949c, (MTCY349.41), len: 199 aa. Conserved hypothetical protein, equivalent to Q9CD83|ML0133 HYPOTHETICAL PROTEIN from Mycobacterium leprae (210 aa), FASTA scores: opt: 797, E(): 7.4e-47, (62.55% identity in 195 aa overlap). Equivalent to AAK47348 from Mycobacterium tuberculosis strain CDC1551 (212 aa) but shorter 13 aa.; hypothetical protein	complement(3299971..3300570)	Mycobacterium tuberculosis H37Rv	887206
NP_217466.2	CDS	fadD29	NC_000962.2	3300596	3302344	R	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	complement(3300596..3302344)	Mycobacterium tuberculosis H37Rv	887202
NP_217467.1	CDS	Rv2951c	NC_000962.2	3303103	3304248	R	Rv2951c, (MTCY349.39), len: 381 aa. Possible oxidoreductase (EC 1.-.-.-), equivalent to Q9CD85 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (382 aa), FASTA scores: opt: 2225, E(): 7.6e-134, (84.8% identity in 382 aa overlap); and similar to O30260 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (363 aa), FASTA scores: opt: 652, E(): 6.1e-34, (32.55% identity in 344 aa overlap). Also similar to various oxidoreductases e.g. O29071|AF1196 N5,N10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from Archaeoglobus fulgidus (348 aa), FASTA scores: opt: 381, E(): 9.7e-17, (27.7% identity in 354 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 372, E(): 3.5e-16, (30.85% identity in 295 aa overlap); Q9UXP0 PUTATIVE F420-DEPENDENT N5,N10-METHYLENE-TETRAHYDROMETHANOPTERIN REDUCTASE from Methanolobus tindarius (326 aa), FASTA scores: opt: 343, E(): 2.4e-14, (27.4% identity in 314 aa overlap); etc.; oxidoreductase	complement(3303103..3304248)	Mycobacterium tuberculosis H37Rv	887887
NP_217468.1	CDS	Rv2952	NC_000962.2	3304441	3305253	D	Rv2952, (MTCY349.38), len: 270 aa. Probable methyltransferase (EC 2.1.1.-), equivalent to Q9CD86|ML0130 HYPOTHETICAL PROTEIN from Mycobacterium leprae (270 aa), FASTA scores: opt: 1584, E(): 6.1e-99, (83.7% identity in 270 aa overlap). Also highly similar to Q9RMN9|MTF2 PUTATIVE METHYLTRANSFERASE from Mycobacterium smegmatis (274 aa), FASTA scores: opt: 902, E(): 3.8e-53, (56.35% identity in 252 aa overlap). Also similar to other methyltransferases e.g. Q9ADL4|SORM O-METHYLTRANSFERASE from Polyangium cellulosum (346 aa), FASTA scores: opt: 390, E(): 1.1e-18, (36.25% identity in 251 aa overlap); Q54303|RAPM METHYLTRANSFERASE from Streptomyces hygroscopicus (317 aa), FASTA scores: opt: 315, E(): 1.1e-13, (40.75% identity in 135 aa overlap); etc. Very similar to C-terminal part of Q50584|Rv1523|MTCY19G5.05c HYPOTHETICAL 37.9 KDA PROTEIN from Mycobacterium tuberculosis (358 aa), FASTA score: opt: 965, E(): 2.7e-57, (60.3% identity in 247 aa overlap).; methyltransferase (methylase)	3304441..3305253	Mycobacterium tuberculosis H37Rv	887311
NP_217469.1	CDS	Rv2953	NC_000962.2	3305279	3306535	D	Rv2953, (MTCY349.37c), len: 418 aa. Conserved hypothetical protein, equivalent to Q9CD87|ML0129 HYPOTHETICAL PROTEIN from Mycobacterium leprae (418 aa), FASTA scores: opt: 2357, E(): 2.7e-143, (86.6% identity in 418 aa overlap). Also highly similar to Q9X7N5|SC5F2A.12c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (396 aa), FASTA scores: opt: 491, E(): 7e-24, (38.35% identity in 417 aa overlap); and similar to other hypothetical proteins e.g. Q9VG81 CG5167 PROTEIN from Drosophila melanogaster (Fruit fly) (431 aa), FASTA scores: opt: 393, E(): 1.4e-17, (26.55% identity in 433 aa overlap); Q9GZE9|F22F7.1 HYPOTHETICAL PROTEIN from Caenorhabditis elegans (426 aa), FASTA scores: opt: 338, E(): 4.6e-14, (27.05% identity in 425 aa overlap); P73855|SLL1601 HYPOTHETICAL 44.8 KDA PROTEIN from Synechocystis sp. (strain PCC 6803) (414 aa), FASTA scores: opt: 565, E(): 1.3e-28, (35.7% identity in 409 aa overlap); etc. Also highly similar to other proteins from Mycobacterium tuberculosis e.g. RV2449C|O53176|MTV008.05C HYPOTHETICAL 44.4 KDA PROTEIN (419 aa), FASTA scores: opt: 1835, E(): 7e-110, (67.55% identity in 419 aa overlap); etc.; hypothetical protein	3305279..3306535	Mycobacterium tuberculosis H37Rv	887772
NP_217470.1	CDS	Rv2954c	NC_000962.2	3306666	3307391	R	Rv2954c, (MTCY349.36), len: 241 aa. Hypothetical unknown protein. Equivalent to AAK47354 from Mycobacterium tuberculosis strain CDC1551 (199 aa) but longer 42 aa.; hypothetical protein	complement(3306666..3307391)	Mycobacterium tuberculosis H37Rv	887214
NP_217471.1	CDS	Rv2955c	NC_000962.2	3307580	3308545	R	Rv2955c, (MTCY349.34), len: 321 aa. Conserved hypothetical protein, similar to others e.g. Q98NV5|MLL9724 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (284 aa), FASTA scores: opt: 231, E(): 6.5e-08, (34.6% identity in 182 aa overlap); Q9AGG2|NLPE1 NLPE1 from Rhizobium etli (249 aa), FASTA scores: opt: 212, E(): 1.1e-06, (27.85% identity in 255 aa overlap); Q9KXY2 HYPOTHETICAL 31.3 KDA PROTEIN from Streptomyces coelicolor(291 aa), FASTA scores: opt: 211, E(): 1.4e-06, (30.9% identity in 249 aa overlap); etc.; hypothetical protein	complement(3307580..3308545)	Mycobacterium tuberculosis H37Rv	887318
NP_217472.1	CDS	Rv2956	NC_000962.2	3308668	3309399	D	Rv2956, (MTCY349.33c), len: 243 aa. Conserved hypothetical protein, highly similar to O86299|GSC GSC PROTEIN from Mycobacterium avium subsp. silvaticum Mycobacterium avium (240 aa), FASTA scores: opt: 1070, E(): 3.5e-63, (67.5% identity in 240 aa overlap); and O86294|GSC GSC PROTEIN from Mycobacterium paratuberculosis (240 aa), FASTA scores: opt: 1070, E(): 3.5e-63, (67.5% identity in 240 aa overlap). Also some similarity with other proteins from other organisms e.g. Q9L727 NODULATION PROTEIN NOEI from Rhizobium fredii (Sinorhizobium fredii) (241 aa), FASTA scores: opt: 205, E(): 3.5e-06, (27.25% identity in 198 aa overlap); Q9AGG1|LPEA LPEA PROTEIN from Rhizobium etli (286 aa), FASTA scores: opt: 201, E(): 7.2e-06, (28.85% identity in 208 aa overlap); P74191|SLL1173 HYPOTHETICAL 28.0 KDA PROTEIN Synechocystis sp. (strain PCC 6803) (244 aa), FASTA scores: opt: 274, E(): 1e-10, (30.65% identity in 225 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. P71792|RV1513|MTCY277.35 HYPOTHETICAL 26.7 KDA PROTEIN (243 aa), FASTA scores: opt: 1105, E(): 1.7e-65, (70.05% identity in 237 aa overlap); etc.; hypothetical protein	3308668..3309399	Mycobacterium tuberculosis H37Rv	887486
NP_217473.1	CDS	Rv2957	NC_000962.2	3309470	3310297	D	Rv2957, (MTCY349.31c), len: 275 aa. Possible glycosyl transferase (EC 2.4.1.-); possibly secreted protein. Highly similar to O88109|GSD|GTFD GSD PROTEIN from Mycobacterium avium subsp. silvaticum, Mycobacterium paratuberculosis, and Mycobacterium avium (266 aa), FASTA scores: opt: 1010, E(): 2.5e-62, (68.8% identity in 221 aa overlap). Also some similarity with other proteins and especially glycosyl transferases e.g. Q9AEE4 HYPOTHETICAL 31.4 KDA PROTEIN from Leptospira interrogans (265 aa), FASTA scores: opt: 371, E(): 3.3e-18, (34.43% identity in 212 aa overlap); Q9EXY4 PUTATIVE GLYCOSYL TRANSFERASE from Escherichia coli (248 aa), FASTA scores: opt: 339, E(): 5e-16, (32.4% identity in 210 aa overlap); Q9RCC4 GLYCOSYLTRANSFERASE-LIKE PROTEIN from Yersinia pestis (247 aa), FASTA scores: opt: 333, E(): 1.3e-15, (31.8% identity in 217 aa overlap); Q9EXY1 PUTATIVE GLYCOSYL TRANSFERASE from Escherichia coli (248 aa), FASTA scores: opt: 328, E(): 2.9e-15, (31.9% identity in 210 aa overlap); etc. Equivalent to AAK47357 from Mycobacterium tuberculosis strain CDC1551 (256 aa) but longer 19 aa.; glycosyl transferase	3309470..3310297	Mycobacterium tuberculosis H37Rv	887258
NP_217474.1	CDS	Rv2958c	NC_000962.2	3310714	3312000	R	Rv2958c, (MTCY349.30), len: 428 aa. Possible glycosyl transferase (EC 2.4.1.-) (see citation below), highly similar to Q9CD88|ML0128 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (435 aa), FASTA scores: opt: 2116, E(): 5.8e-126, (75.05% identity in 417 aa overlap); and Q9CD91|ML0125 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (438 aa), FASTA scores: opt: 2104, E(): 3.3e-125, (74.65% identity in 418 aa overlap). Also shows some similarity to variety of glycosyl transferases e.g. Q9RYI3 PUTATIVE GLYCOSYLTRANSFERASE from Deinococcus radiodurans (418 aa), FASTA scores: opt: 317, E(): 1.9e-12, (31.0% identity in 297 aa overlap); Q9S1V2 PUTATIVE GLYCOSYL TRANSFERASE from Streptomyces coelicolor (407 aa), FASTA scores: opt: 264, E(): 4.1e-09, (27.2% identity in 342 aa overlap); P72650|CRTX|SLR1125 ZEAXANTHIN GLUCOSYL TRANSFERASE from Synechocystis sp. strain PCC 6803 (419 aa), FASTA scores: opt: 251, E(): 2.8e-08, (26.8% identity in 295 aa overlap); etc. Very similar to P95130|MTCY349.25 from Mycobacterium tuberculosis (449 aa), FASTA score: opt: 2215, E(): 3.3e-132, (77.25% identity in 422 aa overlap).; glycosyl transferase	complement(3310714..3312000)	Mycobacterium tuberculosis H37Rv	887816
NP_217475.1	CDS	Rv2959c	NC_000962.2	3312101	3312838	R	Rv2959c, (MTCY349.29), len: 245 aa. Possible methyltransferase (EC 2.1.1.-), highly similar to Q9CD89|ML0127 from Mycobacterium leprae (229 aa), FASTA scores: opt: 1183, E(): 3.9e-69, (76.1% identity in 226 aa overlap). Also some similarity with other methyltransferases and other proteins e.g. Q51079 PUTATIVE METHYL TRANSFERASE from Nocardia lactamdurans (236 aa), FASTA scores: opt: 156, E(): 0.0086, (23.25% identity in 159 aa overlap); Q98ID5 CEPHALOSPORIN HYDROXYLASE from Rhizobium loti (Mesorhizobium loti) (217 aa), FASTA scores: opt: 275, E(): 1.7e-10, (29.65% identity in 199 aa overlap); etc. And also similar to P72897 HYPOTHETICAL 27.8 KDA PROTEIN from Mycobacterium tuberculosis (249 aa), FASTA scores: opt: 292, E(): 1.5e-11, (31.25% identity in 208 aa overlap).; methyltransferase (methylase)	complement(3312101..3312838)	Mycobacterium tuberculosis H37Rv	887862
NP_217476.1	CDS	Rv2960c	NC_000962.2	3312953	3313201	R	Rv2960c, (MT3036, MTCY349.28), len: 82 aa. Hypothetical unknown protein, equivalent to AAK47362 from Mycobacterium tuberculosis strain CDC1551 (116 aa) but shorter 34 aa. Shortened version of MTCY349.28 avoiding overlap.; hypothetical protein	complement(3312953..3313201)	Mycobacterium tuberculosis H37Rv	887224
NP_217477.1	CDS	Rv2961	NC_000962.2	3313283	3313672	D	Rv2961, (MTCY349.26c), len: 129 aa. Probable transposase, highly similar to C-terminus of O50414|Rv3387|MTV004.45 PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis (225 aa), FASTA scores: opt: 605, E(): 7.2e-34, (66.65% identity in 129 aa overlap); and similar to others e.g. CAC47401 PUTATIVE PARTIAL TRANSPOSASE FOR ISRM17 PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (174 aa), FASTA scores: opt: 183, E(): 2.6e-05, (30.25% identity in 129 aa overlap); etc.; transposase	3313283..3313672	Mycobacterium tuberculosis H37Rv	887316
NP_217478.1	CDS	Rv2962c	NC_000962.2	3313773	3315122	R	Rv2962c, (MTCY349.25), len: 508 aa. Possible glycosyl transferase (EC 2.4.1.-) (see citation below), highly similar or identical to Mycobacterium tuberculosis proteins G560522 U0002JA, G560521 U0002H, G560522 U0002JA, G560519 U0002KA. Equivalent (but longer 21 aa) to Q9CD91 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (438 aa), FASTA scores: opt: 2229, E(): 1.3e-133, (77.45% identity in 426 aa overlap); and highly similar to Q9CD88 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (435 aa), FASTA scores: opt: 2129, E(): 2.7e-127, (74.35% identity in 425 aa overlap); and others from Mycobacterium leprae. Also shows some similarity to variety of glycosyl transferases e.g. Q9RYI3|DRA0329 PUTATIVE GLYCOSYL TRANSFERASE from Deinococcus radiodurans (418 aa), FASTA scores: opt: 340, E(): 5.5e-14, (31.2% identity in 330 aa overlap); P72650 ZEAXANTHIN GLUCOSYL TRANSFERASE from Synechocystis sp. (strain PCC 6803) (419 aa), FASTA scores: opt: 244, E(): 6.6e-08, (26.2% identity in 294 aa overlap); etc. Also highly similar to P95134 HYPOTHETICAL 46.8 KDA PROTEIN from Mycobacterium tuberculosis (428 aa), FASTA scores: opt: 2215, E(): 9.6e-133, (77.25% identity in 422 aa overlap).; glycosyl transferase	complement(3313773..3315122)	Mycobacterium tuberculosis H37Rv	887892
NP_217479.1	CDS	Rv2963	NC_000962.2	3315236	3316456	D	Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein.; integral membrane protein	3315236..3316456	Mycobacterium tuberculosis H37Rv	887263
NP_217480.1	CDS	purU	NC_000962.2	3316529	3317461	D	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase	3316529..3317461	Mycobacterium tuberculosis H37Rv	887338
NP_217481.1	CDS	coaD	NC_000962.2	3318330	3318815	R	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase	complement(3318330..3318815)	Mycobacterium tuberculosis H37Rv	888423
NP_217482.1	CDS	Rv2966c	NC_000962.2	3318901	3319467	R	Rv2966c, (MTCY349.21), len: 188 aa. Possible methyltransferase (EC 2.1.1.-), equivalent (but shorter 36 aa) to O69465|MLCB1243.09 HYPOTHETICAL 23.0 KDA PROTEIN from Mycobacterium leprae (220 aa), FASTA scores: opt: 872, E(): 9.1e-50, (74.2% identity in 182 aa overlap). Also similar to others e.g. Q9ZBR2|SC7A1.11 PUTATIVE METHYLASE from Streptomyces coelicolor (195 aa), FASTA scores: opt: 510, E(): 3.7e-26, (47.5% identity in 179 aa overlap); Q9F842 HYPOTHETICAL METHYLTRANSFERASE (FRAGMENT) from Mycobacterium smegmatis (80 aa), FASTA scores: opt: 386, E(): 2.5e-18, (75.0% identity in 80 aa overlap); P10120|YHHF_ECOLI|YHHFZ|B3465 PUTATIVE METHYLASE from Escherichia colistrain K12 (198 aa), FASTA scores: opt: 319, E(): 1.1e-13, (35.5% identity in 183 aa overlap); etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature.; methyltransferase (methylase)	complement(3318901..3319467)	Mycobacterium tuberculosis H37Rv	888469
NP_217483.1	CDS	pca	NC_000962.2	3319663	3323046	R	biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase	complement(3319663..3323046)	Mycobacterium tuberculosis H37Rv	887299
NP_217484.1	CDS	Rv2968c	NC_000962.2	3323071	3323703	R	Rv2968c, (MTCY349.19), len: 210 aa. Probable conserved integral membrane protein, equivalent to O69464 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (214 aa), FASTA scores: opt: 1060, E(): 1.4e-58, (71.95% identity in 214 aa overlap). Also highly similar to others e.g. Q9F844 HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN from Mycobacterium smegmatis (187 aa), FASTA scores: opt: 883, E(): 1.2e-47, (62.8% identity in 190 aa overlap); Q9KXP3 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (240 aa), FASTA scores: opt: 503, E(): 4.6e-24, (38.0% identity in 192 aa overlap); etc.; integral membrane protein	complement(3323071..3323703)	Mycobacterium tuberculosis H37Rv	888476
NP_217485.1	CDS	Rv2969c	NC_000962.2	3323709	3324476	R	Rv2969c, (MTCY349.18), len: 255 aa. Possible conserved membrane or exported protein, equivalent to Q9CBS4|ML1667 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (264 aa), FASTA scores: opt: 1101, E(): 9.9e-68, (65.9% identity in 258 aa overlap); and highly similar to O69463 PUTATIVE TRANSMEMBRANE PROTEIN from Mycobacterium leprae (258 aa), FASTA scores: opt: 1097, E(): 1.8e-67, (65.5% identity in 258 aa overlap). C-terminus also highly similar to Q9KK65|996A160 EXPORTED PROTEIN (FRAGMENT) from Mycobacterium avium (85 aa), FASTA scores: opt: 418, E(): 2e-21, (72.95% identity in 85 aa overlap). Also weakly similar to membrane or exported proteins e.g. Q9S2U7|SC4G6.04c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (275 aa), FASTA scores: opt: 312, E(): 7.6e-14, (28.25% identity in 230 aa overlap); Q9XAB6|SCC22.22C PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (255 aa), FASTA scores: opt: 181, E(): 6.4e-05, (27.0% identity in 226 aa overlap); etc. Also some similarity with P72001|PKNE_MYCTU from Mycobacterium tuberculosis (566 aa), FASTA scores: opt: 264, E(): 2.3e-10, (30.5% identity in 177 aa overlap).; hypothetical protein	complement(3323709..3324476)	Mycobacterium tuberculosis H37Rv	888481
NP_217486.1	CDS	lipN	NC_000962.2	3324573	3325703	R	Rv2970c, (MTCY349.17), len: 376 aa. Probable lipN, lipase/esterase (EC 3.1.1.-), similar to others e.g. Q9AA37|CC0771 PUTATIVE ESTERASE from Caulobacter crescentus (380 aa), FASTA scores: opt: 822, E(): 8e-46, (42.15% identity in 318 aa overlap); Q9XDR4 ESTERASE HDE from petroleum-degrading bacterium HD-1 (317 aa), FASTA scores: opt: 738, E(): 2e-40, (48.85% identity in 262 aa overlap); O52270 LIPASE from Pseudomonas sp. (strain B11-1) (308 aa), FASTA scores: opt: 683, E(): 7.3e-37, (41.3% identity in 288 aa overlap); etc. Also similar to P71668 HYPOTHETICAL 34.1 KDA PROTEIN from Mycobacterium tuberculosis (320 aa), FASTA scores: opt: 715, E(): 6.3e-39, (42.3% identity in 298 aa overlap). Equivalent to AAK47374 from Mycobacterium tuberculosis strain CDC1551 (309 aa) but longer 67 aa.; lipase/esterase LipN	complement(3324573..3325703)	Mycobacterium tuberculosis H37Rv	887194
YP_177681.1	CDS	Rv2970A	NC_000962.2	3325934	3326104	D	Rv2970A, len: 56 aa. Conserved hypothetical protein, similar to C-terminal part of several oxidoreductases e.g. Rv2971|Z83018|MTCY349_22 from Mycobacterium tuberculosis (282 aa), FASTA scores: opt: 158, E(): 3.6e-06, (45.0% identity in 60 aa overlap). May represent a gene fragment.; hypothetical protein	3325934..3326104	Mycobacterium tuberculosis H37Rv	3205038
NP_217487.1	CDS	Rv2971	NC_000962.2	3326101	3326949	D	Rv2971, (MTCY349.16c), len: 282 aa. Probable oxidoreductase (EC 1.-.-.-), possibly aldo/keto reductase, equivalent to O69462 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (282 aa), FASTA scores: opt: 1495, E(): 4.9e-93, (82.35% identity in 272 aa overlap). Also similar to others e.g. Q9KYM9|SC9H11.10C OXIDOREDUCTASE from Streptomyces coelicolor (276 aa), FASTA scores: opt: 849, E(): 1.2e-49, (51.7% identity in 267 aa overlap); Q9ZBW7|SC4B5.01C PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (277 aa), FASTA scores: opt: 847, E(): 1.7e-49, (49.1% identity in 271 aa overlap); Q46857|YQHE_ECOLI|YQHE|B3012 HYPOTHETICAL OXIDOREDUCTASE from Escherichia coli strain K12 (275 aa), FASTA scores: opt: 827, E(): 3.7e-48, (47.45% identity in 276 aa overlap); etc. Contains PS00063 Aldo /keto reductase family putative active site signature; and PS00062 Aldo/keto reductase family signature 2.; oxidoreductase	3326101..3326949	Mycobacterium tuberculosis H37Rv	887275
NP_217488.1	CDS	Rv2972c	NC_000962.2	3327023	3327736	R	Rv2972c, (MTCY349.15), len: 237 aa. Possible conserved membrane or exported protein, equivalent (but longer 52 aa) to O69461|MLCB1243.02 HYPOTHETICAL 20.5 KDA PROTEIN from Mycobacterium leprae (180 aa), FASTA scores: opt: 581, E(): 8.2e-32, (55.75% identity in 174 aa overlap). Also similar to membrane or exported proteins e.g. Q9F2P3|SCE41.16C PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (258 aa), FASTA scores: opt: 498, E(): 4.1e-26, (44.08% identity in 186 aa overlap); Q99QB5|SCP1.323C PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (219 aa), FASTA scores: opt: 329, E(): 8.5e-15, (36.35% identity in 176 aa overlap); Q9ACQ1|SCP1.267 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (219 aa), FASTA scores: opt: 286, E(): 6.6e-12, (32.03% identity in 231 aa overlap); etc.; hypothetical protein	complement(3327023..3327736)	Mycobacterium tuberculosis H37Rv	887191
NP_217489.1	CDS	recG	NC_000962.2	3327733	3329946	R	catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG	complement(3327733..3329946)	Mycobacterium tuberculosis H37Rv	887439
NP_217490.1	CDS	Rv2974c	NC_000962.2	3329949	3331361	R	Rv2974c, (MTCY349.13), len: 470 aa. Conserved hypothetical ala-rich protein, highly similar to others e.g. C-terminus of Q9ZBR4|SC7A1.09 HYPOTHETICAL 59.5 KDA PROTEIN from Streptomyces coelicolor (589 aa), FASTA scores: opt: 774, E(): 1.3e-36, (41.0% identity in 495 aa overlap); Q9K9Z6|BH2498 HYPOTHETICAL PROTEIN from Bacillus halodurans (557 aa), FASTA scores: opt: 268, E(): 8e-08, (27.7% identity in 502 aa overlap) (N-terminus longer 76 aa); Q9X293 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (497 aa), FASTA scores: opt: 265, E(): 1.1e-07, (24.9% identity in 470 aa overlap) (N-terminus longer 43 aa); etc. Also some similarity with P47609|Y369_MYCGE|MG369 HYPOTHETICAL PROTEIN from Mycoplasma genitalium (557 aa), FASTA scores: opt: 154, E(): 0.25, (20.25% identity in 489 aa overlap); this, and following ORF, are similar to Y369_MYCGE but no cosmid sequence error was identified.; hypothetical protein	complement(3329949..3331361)	Mycobacterium tuberculosis H37Rv	887383
NP_217491.1	CDS	Rv2975c	NC_000962.2	3331358	3331612	R	Rv2975c, (MTCY349.12), len: 84 aa. Conserved hypothetical protein, similar to N-terminus of others e.g. Q9ZBR4|SC7A1.09 HYPOTHETICAL 59.5 KDA PROTEIN from Streptomyces coelicolor (589 aa), FASTA scores: opt: 141, E(): 0.0019, (41.25% identity in 80 aa overlap); Q98R49|MYPU_1610 HYPOTHETICAL PROTEIN from Mycoplasma pulmonis (545 aa), FASTA scores: opt: 127, E(): 0.023, (48.0% identity in 50 aa overlap); Q9K9Z6|BH2498 HYPOTHETICAL PROTEIN from Bacillus halodurans (557 aa), FASTA scores: opt: 126, E(): 0.028, (34.55% identity in 81 aa overlap); etc. Also some similarity with N-terminus of P47609|Y369_MYCGE|MG369 HYPOTHETICAL PROTEIN from Mycoplasma genitalium (557 aa), FASTA scores: opt: 108, E(): 0.7, (36.75% identity in 49 aa overlap); this, and preceding ORF, are similar to Y369_MYCGE and YLOV PROTEIN but no cosmid sequence error was identified.; hypothetical protein	complement(3331358..3331612)	Mycobacterium tuberculosis H37Rv	887512
NP_217492.1	CDS	ung	NC_000962.2	3332071	3332754	R	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase	complement(3332071..3332754)	Mycobacterium tuberculosis H37Rv	887410
NP_217493.1	CDS	thiL	NC_000962.2	3332787	3333788	R	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase	complement(3332787..3333788)	Mycobacterium tuberculosis H37Rv	888342
NP_217494.1	CDS	Rv2978c	NC_000962.2	3333785	3335164	R	Rv2978c, (MTCY349.09), len: 459 aa. Probable transposase for IS1538, very similar to several other putative transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809 (460 aa), FASTA scores: opt: 2613, E(): 0, (83.0% identity in 458 aa overlap); etc. Low level matches to other tranposases.; transposase	complement(3333785..3335164)	Mycobacterium tuberculosis H37Rv	887390
NP_217495.1	CDS	Rv2979c	NC_000962.2	3335164	3335748	R	Rv2979c, (MTCY349.08), len: 194 aa. Probable resolvase for IS1538, with low level matches to transposon resolvases; highly similar from aa 101 to YX1C_MYCTU|Q10831 from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 809, E(): 0, (69.1% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site, and possible helix-turn-helix motiv at aa 2-23.; resolvase	complement(3335164..3335748)	Mycobacterium tuberculosis H37Rv	888325
NP_217496.1	CDS	Rv2980	NC_000962.2	3335960	3336505	D	Rv2980, (MTCY349.07c), len: 181 aa. Possible conserved secreted protein, equivalent to Q9CBS1 POSSIBLE SECRETED PROTEIN from Mycobacterium leprae (191 aa), FASTA scores: opt: 794, E(): 2.3e-40, (67.25% identity in 177 aa overlap). Also some weak similarity with other hypothetical proteins or secreted proteins e.g. C-terminus of Q98F98|MLL3872 MLL3872 PROTEIN from Rhizobium loti (Mesorhizobium loti) (575 aa), FASTA scores: opt: 148, E(): 0.16, (28.35% identity in 194 aa overlap); Q9L0W9|SCH22A.13C PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 114, E(): 7.5, (40.0% identity in 80 aa overlap); etc. Equivalent to AAK47385 from Mycobacterium tuberculosis strain CDC1551 (214 aa) but shorter 33 aa. Has hydrophobic stretch near N-terminus.; hypothetical protein	3335960..3336505	Mycobacterium tuberculosis H37Rv	887506
NP_217497.1	CDS	ddl	NC_000962.2	3336796	3337917	R	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A	complement(3336796..3337917)	Mycobacterium tuberculosis H37Rv	888415
NP_217498.1	CDS	gpsA	NC_000962.2	3337995	3338999	R	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	complement(3337995..3338999)	Mycobacterium tuberculosis H37Rv	887864
NP_217499.1	CDS	Rv2983	NC_000962.2	3339118	3339762	D	Rv2983, (MTCY349.04c), len: 214 aa. Conserved hypothetical ala-rich protein, equivalent to O33128|ML1680|MLCB637.37c HYPOTHETICAL 22.0 KDA PROTEIN from Mycobacterium leprae (216 aa), FASTA scores: opt: 1080, E(): 9e-61, (79.05% identity in 215 aa overlap). Also similar to other hypothetical proteins e.g. Q9ZBS2|SC7A1.01C from Streptomyces coelicolor (212 aa), FASTA scores: opt: 420, E(): 2.9e-19, (43.5% identity in 207 aa overlap); O26710|MTH613 from Methanothermobacter thermautotrophicus (223 aa), FASTA scores: opt: 193, E(): 5.8e-05, (30.0% identity in 190 aa overlap); Q9RKG8|SCE46.21 from Streptomyces coelicolor (210 aa), FASTA scores: opt: 139, E(): 0.14, (27.65% identity in 206 aa overlap); etc.; hypothetical protein	3339118..3339762	Mycobacterium tuberculosis H37Rv	888161
NP_217500.1	CDS	ppk	NC_000962.2	3339854	3342082	D	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase	3339854..3342082	Mycobacterium tuberculosis H37Rv	887482
NP_217501.1	CDS	mutT1	NC_000962.2	3342165	3343118	D	Rv2985, (MTCY349.02c), len: 317 aa. Possible mutT1, long MutT protein (hydrolase) (EC 3.-.-.-) (see citation below), highly similar to O33126|MLCB637.35 HYPOTHETICAL 34.5 KDA PROTEIN from Mycobacterium leprae (312 aa), FASTA scores: opt: 1514, E(): 5.1e-91, (71.85% identity in 316 aa overlap); and Q9CBR8|ML1682 HYPOTHETICAL PROTEIN from Mycobacterium leprae (311 aa), FASTA scores: opt: 1510, E(): 9.2e-91, (71.5% identity in 316 aa overlap). Also similar to Q50195|L222-ORF6|ML2698 HYPOTHETICAL PROTEIN from Mycobacterium leprae (251 aa), FASTA scores: opt: 231, E(): 1.1e-07, (36.7% identity in 128 aa overlap). Also similar to shorter mutt proteins and related hypothetical protein e.g. Q9EUS6 HYPOTHETICAL 16.6 KDA PROTEIN from Streptomyces griseus subsp. griseus (152 aa), FASTA scores: opt: 380, E(): 1.7e-17, (50.75% identity in 130 aa overlap); Q9KZV8|SCD84.10C PUTATIVE MUTT-LIKE PROTEIN from Streptomyces coelicolor (142 aa), FASTA scores: opt: 376, E(): 2.9e-17, (46.1% identity in 128 aa overlap); P96590|MUTT MUTT PROTEIN from Bacillus subtilis (149 aa), FASTA scores: opt: 180, E(): 0.00017, (35.25% identity in 122 aa overlap); etc. Also similar to O05437 HYPOTHETICAL 27.1 KDA PROTEIN from Mycobacterium tuberculosis (248 aa), FASTA scores: opt: 224, E(): 3.2e-07, (34.03% identity in 144 aa overlap). Contains PS00893 mutT domain signature. SEEMS TO BELONG TO THE MUTT/NUDIX FAMILY PROTEIN.; hydrolase MutT1	3342165..3343118	Mycobacterium tuberculosis H37Rv	888165
NP_217502.1	CDS	hupB	NC_000962.2	3343176	3343820	R	Rv2986c, (MTCY349.01), len: 214 aa. Probable hupB (alternate gene names: hup, hlp, lbp21), DNA-binding protein HU homolog (resembles fusion between HU and histone) (see Pethe et al., 2002), equivalent to others from Mycobacteria e.g. Q9XB18|DBH_MYCBO from Mycobacterium bovis (205 aa), FASTA scores: opt: 1050, E(): 5.6e-45, (95.35% identity in 214 aa overlap); Q9ZHC5|DBH_MYCSM from Mycobacterium smegmatis (208 aa), FASTA scores: opt: 1035, E(): 3.1e-44, (80.2% identity in 217 aa overlap); and O33125|DBH_MYCLE from Mycobacterium leprae (200 aa), FASTA scores: opt: 914, E(): 2.7e-38, (80.1% identity in 216 aa overlap). Also highly similar to others from other organisms e.g. O86537|DBH2_STRCO from Streptomyces coelicolor (218 aa), FASTA scores: opt: 569, E(): 2.6e-21, (51.35% identity in 220 aa overlap); P08821|DBH1_BACSU from Bacillus subtilis (92 aa), FASTA scores: opt: 280, E(): 2.5e-07, (45.05% identity in 91 aa overlap) (C-terminus shorter); etc. Contains PS00045 Bacterial histone-like DNA-binding proteins signature. BELONGS TO THE BACTERIAL HISTONE-LIKE PROTEIN FAMILY. Note that its C-terminal domain is very rich in lysine and alanine.; hup; hlp; lbp21; DNA-binding protein HU	complement(3343176..3343820)	Mycobacterium tuberculosis H37Rv	888166
NP_217503.1	CDS	leuD	NC_000962.2	3344033	3344629	R	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit	complement(3344033..3344629)	Mycobacterium tuberculosis H37Rv	888225
NP_217504.1	CDS	leuC	NC_000962.2	3344654	3346075	R	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit	complement(3344654..3346075)	Mycobacterium tuberculosis H37Rv	887875
NP_217505.1	CDS	Rv2989	NC_000962.2	3346147	3346848	D	Rv2989, (MTV012.03), len: 233 aa. Probable transcriptional regulator (ala-rich protein), highly similar to O86533|SC1C2.33c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (238 aa), FASTA scores: opt: 711, E(): 2.3e-38, (53.05% identity in 230 aa overlap); and similar to others e.g. Q9KND6 PUTATIVE TRANSCRIPTIONAL REGULATOR from Vibrio cholerae (244 aa), FASTA scores: opt: 232, E(): 1.2e-07, (29.75% identity in 232 aa overlap); Q9R9U0|SRPS EFFLUX PUMP REGULATOR from Pseudomonas putida (259 aa), FASTA scores: opt: 224, E(): 4.1e-07, (28.35% identity in 247 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. O06806|Rv1773c|MTCY28.39 HYPOTHETICAL 26.6 KDA PROTEIN (248 aa), FASTA scores: opt: 239, E(): 4.4e-08, (29.85% identity in 231 aa overlap); P71977|RV1719|MTCY04C12.04 HYPOTHETICAL 27.9 KDA PROTEIN (259 aa), FASTA scores: opt: 215, E(): 1.6e-06, (31.85% identity in 223 aa overlap); etc. Equivalent to AAK47396 from Mycobacterium tuberculosis strain CDC1551 (267 aa) but shorter 34 aa. Contains possible helix-turn-helix motif at aa 25-46 (Score 1005, +2.61 SD). TBparse score is 0.894.; transcriptional regulatory protein	3346147..3346848	Mycobacterium tuberculosis H37Rv	887723
NP_217506.1	CDS	Rv2990c	NC_000962.2	3346859	3347719	R	Rv2990c, (MTV012.04c), len: 286 aa. Hypothetical unknown protein. TBparse score is 0.923.; hypothetical protein	complement(3346859..3347719)	Mycobacterium tuberculosis H37Rv	887176
NP_217507.1	CDS	Rv2991	NC_000962.2	3347982	3348473	D	Rv2991, (MTV012.05), len: 163 aa. Conserved hypothetical protein, similar to others e.g. Q9K3X7|2SCG61.39. HYPOTHETICAL 17.6 KDA PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85% identity in 155 aa overlap); Q9CNX3|PM0299 HYPOTHETICAL PROTEIN from Pasteurella multocida (171 aa), FASTA scores: opt: 175, E(): 5.1e-05, (31.3% identity in 131 aa overlap); Q9KZI9|SCG8A.10 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (142 aa), FASTA scores: opt: 163, E(): 0.00031, (32.4% identity in 108 aa overlap); etc. Also some similarity to O06553|MTCI65.22|Rv1155 hypothetical protein from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 127, E(): 0.1, (32.9% identity in 73 aa overlap); and to several proteins of similar size that confer resistance to 5-Nitroimidazole antibiotics in Bacteroides. TBparse score is 0.871.; hypothetical protein	3347982..3348473	Mycobacterium tuberculosis H37Rv	887792
YP_177915.1	CDS	gltX	NC_000962.2	3348805	3350277	R	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase	complement(3348805..3350277)	Mycobacterium tuberculosis H37Rv	887850
NP_217509.1	CDS	Rv2993c	NC_000962.2	3350274	3350993	R	Rv2993c, (MTV012.07c), len: 239 aa. Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-), equivalent to O33119|ML1689|MLCB637.28 POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE- 1,7-DIOATE ISOMERASE from Mycobacterium leprae (242 aa), FASTA scores: opt: 1427, E(): 4.4e-86, (85.9% identity in 241 aa overlap). Also similar to others e.g. Q9LBE3|DR1609 from Deinococcus radiodurans (250 aa), FASTA scores: opt: 723, E(): 5.5e-40, (49.05% identity in 216 aa overlap); O27551|MTH1507 from Methanothermobacter thermautotrophicus (260 aa), FASTA scores: opt: 708, E(): 5.4e-39, (52.1% identity in 213 aa overlap); Q9HQR6|VNG1037G|HPCE from Halobacterium sp. (strain NRC-1) (244 aa), FASTA scores: opt: 590, E(): 2.7e-31, (43.65% identity in 220 aa overlap); etc. Start chosen by homology, but ORF could continue upstream. TBparse score is 0.896.; 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase	complement(3350274..3350993)	Mycobacterium tuberculosis H37Rv	887867
NP_217510.1	CDS	Rv2994	NC_000962.2	3351269	3352606	D	Rv2994, (MTV012.08), len: 445 aa. Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug. C-terminal part highly similar to O33118|MLCB637.27c HYPOTHETICAL 14.7 KDA PROTEIN (probable pseudogene product) from Mycobacterium leprae (134 aa), FASTA scores: opt: 483, E(): 2.7e-21, (60.9% identity in 138 aa overlap). Also similar to various transporters e.g. Q9I5C8|PA0811 PROBABLE MFS TRANSPORTER from Pseudomonas aeruginosa (415 aa), FASTA scores: opt: 289, E(): 1.3e-09, (26.05% identity in 399 aa overlap); O30210|AF0025 CYANATE TRANSPORT PROTEIN from Archaeoglobus fulgidus (393 aa), FASTA scores: opt: 281, E(): 3.7e-09, (24.05% identity in 399 aa overlap); Q9RI35|SCJ12.25C PUTATIVE NITRATE/NITRITE TRANSPORTER from Streptomyces coelicolor (412 aa), FASTA scores: opt: 264, E(): 3.8e-08, (24.95% identity in 409 aa overlap); Q9A5N5|CC2412 MAJOR FACILITATOR FAMILY TRANSPORTER from Caulobacter crescentus (405 aa), FASTA scores: opt: 263, E(): 4.3e-08, (27.55% identity in 399 aa overlap); etc. First start taken; similarity to P21191|NORA_STAAU QUINOLONE RESISTANCE PROTEIN from Staphylococcus aureus (388 aa) suggests alternative start at 7319 but then no positively charged aa before first transmembrane segment. TBparse score is 0.925.; integral membrane protein	3351269..3352606	Mycobacterium tuberculosis H37Rv	888200
NP_217511.1	CDS	leuB	NC_000962.2	3352458	3353468	R	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase	complement(3352458..3353468)	Mycobacterium tuberculosis H37Rv	888182
YP_177916.1	CDS	serA1	NC_000962.2	3353483	3355069	R	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase	complement(3353483..3355069)	Mycobacterium tuberculosis H37Rv	887154
NP_217513.1	CDS	Rv2997	NC_000962.2	3355099	3356541	D	Rv2997, (MTV012.11), len: 480 aa. Possible ala-rich dehydrogenase (EC 1.-.-.-), similar to others dehydrogenases and hypothetical proteins e.g. Q9EYI5 PUTATIVE DEHYDROGENASE from Streptomyces nogalater (472 aa), FASTA scores: opt: 1131, E(): 1.7e-61, (41.0% identity in 471 aa overlap); Q9ZBG4|SC9B5.16 PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (472 aa), FASTA scores: opt: 1064, E(): 2e-57, (39.05% identity in 471 aa overlap); Q98BS8 PROBABLE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (524 aa), FASTA scores: opt: 196, E(): 0.00021, (25.1% identity in 526 aa overlap); etc. Shows strong simlarity throughout its length to O06826|MTCY493.22c|Rv1432 HYPOTHETICAL 50.5 KDA PROTEIN from Mycobacterium tuberculosis (473 aa), FASTA scores: opt: 1220, E(): 6.1e-67, (42.35% identity in 465 aa overlap). TBparse score is 0.896.; alanine rich dehydrogenase	3355099..3356541	Mycobacterium tuberculosis H37Rv	888637
NP_217514.1	CDS	Rv2998	NC_000962.2	3356815	3357276	D	Rv2998, (MTV012.12), len: 153 aa. Hypothetical unknown protein. Note that equivalent to AAK47405 Hypothetical 19.4 kDa protein from Mycobacterium tuberculosis strain CDC1551 (186 aa) but sequence differs in N-terminus. TBparse score is 0.938.; hypothetical protein	3356815..3357276	Mycobacterium tuberculosis H37Rv	888646
YP_177682.1	CDS	Rv2998A	NC_000962.2	3357225	3357428	R	Rv2998A, len: 67 aa. Probable conserved hypothetical protein, (possibly gene fragment), highly similar to central part of two-component sensor proteins e.g. O07777|Rv0601c|MTCY19H5.21 TWO COMPONENT SENSOR (FRAGMENT) from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 212, E(): 3.7e-09, (58.2% identity in 67 aa overlap); Q9L2B6|SC8F4.08 PROBABLE TWO-COMPONENT SENSOR KINASE from Streptomyces coelicolor (478 aa), FASTA scores: opt: 193, E(): 2.6e-07, (47.05% identity in 68 aa overlap); etc.; hypothetical protein	complement(3357225..3357428)	Mycobacterium tuberculosis H37Rv	3205090
NP_217515.1	CDS	lppY	NC_000962.2	3357602	3358567	D	Rv2999, (MTV012.13), len: 321 aa. Probable lppY, conserved lipoprotein, highly similar to O07774|LPQO|Rv0604|MTCY19H5.18c PUTATIVE LIPOPROTEIN from Mycobacterium tuberculosis (316 aa), FASTA scores: opt: 1153, E(): 5e-62, (53.2% identity in 312 aa overlap); and showing similarity with AAK80743|CAC2799 UNCHARACTERIZED CONSERVED PROTEIN SIMILAR TO LPPY/LPQO OF Mycobacterium tuberculosis from Clostridium acetobutylicum (152 aa), FASTA scores: opt: 165, E(): 0.0077, (26.08% identity in 138 aa overlap); and Q9F2T1|SCD65.01c PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (146 aa), FASTA scores: opt: 126, E(): 1.6, (% identity in aa overlap). Equivalent to AAK47407 from Mycobacterium tuberculosis strain CDC1551 (329 aa) but shorter 8 aa. Contains probable N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.892.; lipoprotein LppY	3357602..3358567	Mycobacterium tuberculosis H37Rv	887357
NP_217516.1	CDS	Rv3000	NC_000962.2	3358612	3359271	D	Rv3000, (MTV012.14), len: 219 aa. Possible conserved transmembrane protein, similar to various membrane proteins e.g. P77307|YBBM_ECOLI|B0491 HYPOTHETICAL 28.2 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Escherichia coli strain K12 (259 aa), FASTA scores: opt: 292, E(): 3.1e-11, (30.25% identity in 218 aa overlap); N-terminus of Q9BJF3 PUTATIVE ABC TRANSPORTER (FRAGMENT) from Sterkiella histriomuscorum (1319 aa), FASTA scores: opt: 274, E(): 1.3e-09, (39.6% identity in 101 aa overlap); Q9C9W0|T23K23.21 PUTATIVE ABC TRANSPORTER from Arabidopsis thaliana (Mouse-ear cress) (263 aa), FASTA scores: opt: 258, E(): 4.4e-09, (30.1% identity in 196 aa overlap); P74369|YG47_SYNY3|SLR1647 HYPOTHETICAL 28.1 KDA PROTEIN (POTENTIAL INTEGRAL MEMBRANE PROTEIN) from Synechocystis sp. strain PCC 6803 (259 aa), FASTA scores: opt: 257, E(): 5.1e-09, (37.75% identity in 98 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.921.; transmembrane protein	3358612..3359271	Mycobacterium tuberculosis H37Rv	887271
NP_217517.1	CDS	ilvC	NC_000962.2	3359585	3360586	R	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase	complement(3359585..3360586)	Mycobacterium tuberculosis H37Rv	887483
NP_217518.1	CDS	ilvH	NC_000962.2	3360624	3361130	R	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit	complement(3360624..3361130)	Mycobacterium tuberculosis H37Rv	887226
YP_177917.1	CDS	ilvB1	NC_000962.2	3361130	3362986	R	acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit	complement(3361130..3362986)	Mycobacterium tuberculosis H37Rv	887286
NP_217520.1	CDS	cfp6	NC_000962.2	3363348	3363686	D	Rv3004, (MT3084.1, MTV012.18), len: 112 aa. cfp6, low molecular weight protein antigen 6 (CFP-6) (cf note * below). Weak homology with Q9RKZ5|SC6D7.02 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (156 aa), FASTA scores: opt: 109, E(): 0.78, (39.4% identity in 122 aa overlap). CAUTION: THE INITIATOR METHIONINE MAY BE FURTHER UPSTREAM MAKING THE SEQUENCE A PRECURSOR. TBparse score is 0.873. [* Note: Bhaskar S., Mukherjee R.: Isolation, purification and immunological characterization of low molecular weight protein antigens from culture filtrate of Mycobacterium tuberculosis H37Rv. Unpublished. Submitted (NOV-1998) to the SWISS-PROT data bank].; low molecular weight protein antigen 6 (CFP-6)	3363348..3363686	Mycobacterium tuberculosis H37Rv	887891
NP_217521.1	CDS	Rv3005c	NC_000962.2	3363693	3364532	R	Rv3005c, (MTV012.19c), len: 279 aa. Conserved hypothetical protein, equivalent to O33110|MLCB637.18|ML1698 HYPOTHETICAL 29.5 KDA PROTEIN from Mycobacterium leprae (277 aa), FASTA scores: opt: 1245, E(): 1.2e-65, (70.5% identity in 278 aa overlap). Also similar, but longer 100 aa in N-terminus, to other hypothetical proteins, few membrane proteins, e.g. Q9RKN9|SCC75A.35 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (180 aa), FASTA scores: opt: 326, E(): 3.9e-12, (44.2% identity in 138 aa overlap); P96694|YDFP|AB001488 HYPOTHETICAL PROTEIN from Bacillus subtilis (129 aa), FASTA scores: opt:273, E(): 3.7e-09, (33.1% identity in 130 aa overlap); Q9KKT1|VCA1019 HYPOTHETICAL PROTEIN from Vibrio cholerae (148 aa), FASTA scores: opt: 258, E(): 3.1e-08, (34.9% identity in 126 aa overlap); etc. TBparse score is 0.912.; hypothetical protein	complement(3363693..3364532)	Mycobacterium tuberculosis H37Rv	887305
NP_217522.1	CDS	lppZ	NC_000962.2	3364709	3365830	D	Rv3006, (MTV012.20), len: 373 aa. Probable lppZ, conserved lipoprotein, equivalent to O33109|MLCB637.17C|ML1699 putative lipoprotein from M. leprae (372 aa), FASTA scores: opt: 2211, E(): 4.3e-100, (87.1% identity in 373 aa overlap). Shows also similarity (in part) with Q9Z571|SC8D9.20c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (447 aa), FASTA scores: opt: 185, E(): 0.051, (31.6% identity in 300 aa overlap); Q9Z9R3|BH2090 GLUCOSE DEHYDROGENASE-B from Bacillus halodurans (371 aa), FASTA scores: opt: 206, E(): 0.0043, (28.3% identity in 205 aa overlap); and other GLUCOSE DEHYDROGENASES B. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, followed by a proline-rich domain. TBparse score is 0.900.; lipoprotein LppZ	3364709..3365830	Mycobacterium tuberculosis H37Rv	887308
NP_217523.1	CDS	Rv3007c	NC_000962.2	3365836	3366450	R	Rv3007c, (MTV012.21c), len: 204 aa. Possible oxidoreductase (EC 1.-.-.-), similar to Q9EWU5|3SC5B7.04c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (162 aa), FASTA scores: opt: 376, E(): 1.5e-18, (41.35% identity in 150 aa overlap); Q9K416|SCG22.29c PUTATIVE FLAVIN-DEPENDENT REDUCTASE PROTEIN from Streptomyces coelicolor (169 aa), FASTA scores: opt: 246, E(): 1e-09, (34.1% identity in 135 aa overlap); and some similarity to coupling proteins of 4-hydroxyphenylacetic hydroxylase/monooxygenase e.g. Q9HWT6|HPAC|PA4092 Pseudomonas aeruginosa (170 aa), FASTA score: opt: 214; O68232|HPAC Photorhabdus luminescens (Xenorhabdus luminescens) (172 aa), FASTA score: opt: 198; Q9RPU2|HPAC Salmonella dublin (170 aa), FASTA score: opt: 197; etc. Equivalent to AAK47416 from Mycobacterium tuberculosis strain CDC1551 (236 aa) but shorter 32 aa. Start chosen by similarity. TBparse score is 0.930.; oxidoreductase	complement(3365836..3366450)	Mycobacterium tuberculosis H37Rv	888938
NP_217524.1	CDS	Rv3008	NC_000962.2	3366644	3367267	D	Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein.; hypothetical protein	3366644..3367267	Mycobacterium tuberculosis H37Rv	888530
NP_217525.1	CDS	gatB	NC_000962.2	3367264	3368793	R	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B	complement(3367264..3368793)	Mycobacterium tuberculosis H37Rv	888919
NP_217526.1	CDS	pfkA	NC_000962.2	3368823	3369854	R	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase	complement(3368823..3369854)	Mycobacterium tuberculosis H37Rv	888509
NP_217527.1	CDS	gatA	NC_000962.2	3369950	3371434	R	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A	complement(3369950..3371434)	Mycobacterium tuberculosis H37Rv	887262
NP_217528.1	CDS	gatC	NC_000962.2	3371431	3371730	R	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C	complement(3371431..3371730)	Mycobacterium tuberculosis H37Rv	887335
NP_217529.1	CDS	Rv3013	NC_000962.2	3371815	3372471	D	Rv3013, (MTV012.27), len: 218 aa. Conserved hypothetical protein, equivalent to O33103|MLCB637_11c HYPOTHETICAL 24.4 KDA PROTEIN from Mycobacterium leprae (230 aa), FASTA scores: opt: 1188, E(): 2.6e-67, (83.95% identity in 218 aa overlap). Equivalent to AAK47422 from Mycobacterium tuberculosis strain CDC1551 (240 aa) but shorter 22 aa. TBparse score is 0.879.; hypothetical protein	3371815..3372471	Mycobacterium tuberculosis H37Rv	888642
NP_217530.1	CDS	ligA	NC_000962.2	3372545	3374620	R	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA	complement(3372545..3374620)	Mycobacterium tuberculosis H37Rv	887354
NP_217531.1	CDS	Rv3015c	NC_000962.2	3374651	3375664	R	Rv3015c, (MTV012.29c), len: 337 aa. Conserved hypothetical protein, equivalent to Q9CBR6|ML1706 HYPOTHETICAL PROTEIN from Mycobacterium leprae (337 aa), FASTA scores: opt: 1703, E(): 3.1e-92, (78.05% identity in 337 aa overlap); and (but longer 47 aa) O33101|MLCB637.09 HYPOTHETICAL 30.0 KDA PROTEIN from Mycobacterium leprae (290 aa), FASTA scores: opt: 1564, E(): 2.4e-78, (78.6% identity in 290 aa overlap). Also similar to Q9Z586|SC8D9.05 HYPOTHETICAL 35.0 KDA PROTEIN from Streptomyces coelicolor (331 aa), FASTA scores: opt: 774, E(): 4.7e-38, (43.4% identity in 334 aa overlap); and showing similarity with other proteins e.g. Q39586|METE_CHLRE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE from Chlamydomonas reinhardtii (814 aa), FASTA scores: opt: 162, E(): 0.048, (27.05% identity in 355 aa overlap). TBparse score is 0.906.; hypothetical protein	complement(3374651..3375664)	Mycobacterium tuberculosis H37Rv	887181
NP_217532.1	CDS	lpqA	NC_000962.2	3375758	3376387	D	Rv3016, (MTV012.30), len: 209 aa. Probable lpqA, lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.921.; lipoprotein LpqA	3375758..3376387	Mycobacterium tuberculosis H37Rv	888557
NP_217533.1	CDS	esxQ	NC_000962.2	3376490	3376852	R	Rv3017c, (MT3097, MTV012.31c), len: 120 aa. esxQ, ESAT-6 like protein (see citation below), possibly secreted protein, very similar to AAK47433|MT3104 PUTATIVE SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium tuberculosis strain CDC1551 (96 aa), FASTA scores: opt: 315, E(): 1.2e-14, (65.7% identity in 70 aa overlap); Rv3019c|O53266|MTV012.33c PUTATIVE SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 315, E(): 1.2e-14, (65.7% identity in 70 aa overlap) and Rv0288|O53693|CFP7|MT0301|MTV035.16 10 KDA ANTIGEN CFP7 (LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 7) (CFP-7) from Mycobacterium tuberculosis (95 aa), FASTA scores: opt: 303, E(): 7.4e-14, (66.2% identity in 68 aa overlap). BELONGS TO THE ESAT6 FAMILY. Note previously known as TB12.9.; TB12.9, ES6_8; Esat-6 like protein esxQ (TB12.9) (Esat-6 like protein 8)	complement(3376490..3376852)	Mycobacterium tuberculosis H37Rv	888508
YP_177918.1	CDS	PPE46	NC_000962.2	3376939	3378243	R	Rv3018c, (MTV012.32c), len: 434 aa. Member of PPE family but lacks Gly, Ala rich repeats at C-terminal domain, closest to MTCY261.19. See citation below. Also very similar to following ORF MTV012.35c. Nearly identical in parts to Mycobacterium tuberculosis protein erroneously described as DIHYDROFOLATE REDUCTASE (X59271|MTFOLA_1) P31500|DYR_MYCTU (214 aa), FASTA scores: opt: 972, E(): 4.4e-42, (80.0% identity in 195 aa overlap); and Z97559|MTCY261_19 from Mycobacterium tuberculosis cosmid (473 aa), FASTA scores: opt: 806, E(): 0; (38.8% identity in 479 aa overlap); and O53268|MTV012.35c from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 1714, E(): 3.3e-79, (78.3% identity in 355 aa overlap). TBparse score is 0.945.; PPE family protein	complement(3376939..3378243)	Mycobacterium tuberculosis H37Rv	888940
NP_217535.1	CDS	esxR	NC_000962.2	3378711	3379001	R	Rv3019c, (MT3104, MTV012.33c), len: 96 aa. esxR, secreted ESAT-6 like protein (see citations below), most similar to O53693|AAK44525|Rv0288|CFP7|MT0301|MTV035.16 10 KDA ANTIGEN CFP7 (LOW MOLECULAR WEIGHT PROTEIN ANTIGEN 7) (CFP-7) from Mycobacterium tuberculosis (95 aa), FASTA scores: opt: 566, E(): 5.1e-31, (84.3% identity in 95 aa overlap). Also similar to Q9CD33|ML2531 POSSIBLE CELL SURFACE PROTEIN from Mycobacterium leprae (96 aa), FASTA scores: opt: 472, E(): 8.3e-25, (66.6% identity in 96 aa overlap); O53264|Rv3017c|MTV012.31c PUTATIVE SECRETED ANTIGEN from Mycobacterium tuberculosis (120 aa), FASTA scores: opt: 321, E(): 9.6e-15, (67.15% identity in 70 aa overlap); Q57165|AAK48357|O84901|X79562|ESAT6|Rv3875|MT3989|MTV027. 10 esat6 gene from Mycobacterium tuberculosis strain Erdman (94 aa), FASTA scores: opt: 131, E(): 0.028, (26.1% identity in 88 aa overlap). BELONGS TO THE ESAT6 FAMILY. TBparse score is 0.906. Note previously known as TB10.3.; ES6_9, TB10.3; secreted ESAT-6 like protein ESXR (TB10.3) (ESAT-6 like protein 9)	complement(3378711..3379001)	Mycobacterium tuberculosis H37Rv	888926
YP_177919.1	CDS	esxS	NC_000962.2	3379036	3379329	R	Rv3020c, (MTV012.34c), len: 97 aa. esxS, ESAT-6 like protein. PE-family related protein; distant member of the Mycobacterium tuberculosis PE family, similar to AAK44524|MT0300 PE FAMILY PROTEIN from M. tuberculosis strain CDC1551 (97 aa), FASTA scores: opt: 564, E(): 5.9e-30, (91.75% identity in 97 aa overlap). Has potential helix-turn-helix motif at positions 14-35. TBparse score is 0.912. SEEMS TO BELONG TO THE ESAT6 FAMILY (see Betts et al., 2002). Note that previously known as PE28.; PE28; Esat-6 like protein esxS	complement(3379036..3379329)	Mycobacterium tuberculosis H37Rv	888946
YP_177920.1	CDS	PPE47	NC_000962.2	3379376	3380452	R	Rv3021c, (MTV012.35c), len: 358 aa. Member of Mycobacterium tuberculosis PPE family. Should be continuation of upstream ORF MTV012.36c but is frameshifted due to missing base at 36448 in v012. Sequence has been checked but no error apparent. Very similar to neighbouring ORF O53265|MTV012.32c|Rv3018c from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 1714, E(): 6.6e-770, (78.3% identity in 355 aa overlap) and AAK47430|MT3101 (strongly in the N-terminal part) (310 aa), FASTA scores: opt: 897, E(): 4.5e-37, (66.95% identity in 227 aa overlap). TBparse score is 0.943.; PPE family protein	complement(3379376..3380452)	Mycobacterium tuberculosis H37Rv	888924
YP_177684.1	CDS	PPE48	NC_000962.2	<3380440	>3380682	R	Rv3022c, (MTV012.36c), len: 81 aa. Member of M. tuberculosis PPE family with frameshift due to missing bp in codon 82. The ORF continues in downstream MTV012.35c. The sequence has been checked and no errors were detected. Identical to neigbouring ORF O53265|Rv3018c|MTV012.32c (434 aa), FASTA scores: opt: 526, E(): 6.2e-26, (100.0% identity in 81 aa overlap); and O69706|Rv739c|MTV025.087c (77 aa), FASTA scores: opt: 392, E(): 3.4e-18, (72.7% identity in 77 aa overlap). TBparse score is 0.901.; PPE family protein	complement(<3380440..>3380682)	Mycobacterium tuberculosis H37Rv	888512
YP_177685.1	CDS	PE29	NC_000962.2	3380679	3380993	R	Rv3022A, len: 104 aa. Member of the Mycobacterium tuberculosis PE family (see citation below), similar to many others e.g. Rv0285|AL021930_12 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 497, E(): 3e-21, (80.39% identity in 102 aa overlap); etc.; PE family protein	complement(3380679..3380993)	Mycobacterium tuberculosis H37Rv	3205088
NP_217539.1	CDS	Rv3023c	NC_000962.2	3381375	3382622	R	Rv3023c, (MTV012.38c), len: 415 aa. Probable IS1081 transposase. Contains PS01007 Transposases, Mutator family, signature. Similars to P35882|TRA1_MYCTU|Rv1199c|MTCI364.11c and Rv2512c|MTCY07A7.18c TRANSPOSASES FOR INSERTION SEQUENCE ELEMENT IS1081 (415 aa), FASTA scores: opt: 2675, E(): 1.8e-162, (100.0% identity in 415 aa overlap). TBparse score is 0.894. BELONGS TO THE MUTATOR FAMILY OF TRANSPOSASE.; transposase	complement(3381375..3382622)	Mycobacterium tuberculosis H37Rv	888525
NP_217540.1	CDS	mnmA	NC_000962.2	3382785	3383888	R	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA	complement(3382785..3383888)	Mycobacterium tuberculosis H37Rv	888524
NP_217541.1	CDS	iscS	NC_000962.2	3383885	3385066	R	Rv3025c, (MTV012.40c), len: 393 aa. Probable iscS (alternate gene name: nifS), cysteine desulfurase (NifS-like protein) (EC 4.4.1.-), equivalent to MLCB637.06|O33098 NIFS-LIKE PROTEIN from Mycobacterium leprae (396 aa), FASTA scores: opt: 2186, E(): 2.7e-122, (84.9% identity in 391 aa overlap). Also highly similar to many e.g. O86581|SC2A11.20 PUTATIVE PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASE from Streptomyces coelicolor (389 aa), FASTA scores: opt: 1568, E(): 1.1e-85, (61.7% identity in 389 aa overlap); P57795|ISCS|NIFS CYSTEINE DESULFURASE (NIFS PROTEIN HOMOLOG) from Methanosarcina thermophila (404 aa), FASTA scores: opt: 1059, E(): 1.6e-55, (46.2% identity in 381 aa overlap); O54055|ISCS_RUMFL|ISCS|NIFS CYSTEINE DESULFURASE from Ruminococcus flavefaciens (396 aa), FASTA scores: opt: 973, E(): 2e-50, (43.3% identity in 381 aa overlap); P57794|NIFS_ACEDI CYSTEINE DESULFURASE from Acetobacter diazotrophicus (400 aa), FASTA scores: opt: 958, E(): 1.6e-49, (41.1% identity in 392 aa overlap); etc. Also similar to Rv1464|MTV007.11 from Mycobacterium tuberculosis. Contains PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. BELONGS TO CLASS-V OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES, NIFS/ISCS SUBFAMILY. COFACTOR: PYRIDOXAL PHOSPHATE (BY SIMILARITY).; nifS; cysteine desulfurase IscS	complement(3383885..3385066)	Mycobacterium tuberculosis H37Rv	887677
NP_217542.1	CDS	Rv3026c	NC_000962.2	3385163	3386077	R	Rv3026c, (MTV012.41c), len: 304 aa. Conserved hypothetical protein, similar to Q9RCZ0|SCM10.08C PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (275 aa), FASTA scores: opt: 393, E(): 2.2e-17, (41.4% identity in 299 aa overlap). Similar in part to other hypothetical proteins and acyltransferases e.g. BAB51968|MLR5533 from Rhizobium loti (266 aa), FASTA scores: opt: 280, E(): 2.4e-10, (29.45% identity in 258 aa overlap); Q9KIH9 PUTATIVE ACYLTRANSFERASE (PUTATIVE ACYLTRANSFERASE TRANSMEMBRANE PROTEIN) (EC 2.3.1.) from Rhizobium meliloti (Sinorhizobium meliloti) (292 aa), FASTA scores: opt: 252, E(): 1.4e-08, (30.5% identity in 210 aa overlap); O69114|PLSC PUTATIVE 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE from Burkholderia pseudomallei (Pseudomonas pseudomallei) (289 aa), FASTA scores: opt: 216, E(): 2.4e-06, (30.85% identity in 269 aa overlap); etc. So may be a member of acyltransferase family protein.; hypothetical protein	complement(3385163..3386077)	Mycobacterium tuberculosis H37Rv	888489
NP_217543.1	CDS	Rv3027c	NC_000962.2	3386074	3386814	R	Rv3027c, (MTV012.42c), len: 246 aa. Conserved hypothetical protein, similar, but shorter 30 aa in N-terminus, to others e.g. Q9RCY9|SCM10.09c from Streptomyces coelicolor (256 aa), FASTA scores: opt: 498, E(): 7.8e-24, (47.7% identity in 237 aa overlap); BAB50158|MLR3216 from Rhizobium loti (291 aa), FASTA scores: opt: 359, E(): 3.7e-15, (33.35% identity in 246 aa overlap); etc. Equivalent to AAK47441 from Mycobacterium tuberculosis strain CDC1551 (281 aa) but shorter 35 aa.; hypothetical protein	complement(3386074..3386814)	Mycobacterium tuberculosis H37Rv	887851
NP_217544.1	CDS	fixB	NC_000962.2	3387075	3388031	R	Rv3028c, (MTV012.43c), len: 318 aa. Probable fixB (alternate gene name: etfA), electron transfer flavoprotein (alpha subunit) for various dehydrogenases. Equivalent to O33096|ETFA_MYCLE|FIXB|ML1711|MLCB637.04 ELECTRON TRANSFER FLAVOPROTEIN from Mycobacterium leprae (318 aa), FASTA scores: opt: 1788, E(): 1.1e-87, (89.3% identity in 318 aa overlap). Also highly similar to many e.g. Q9K418|SCG22.27c from Streptomyces coelicolor (320 aa), FASTA scores: opt: 1161, E(): 1.6e-54, (59.45% identity in 323 aa overlap); AAK08137|etfa from Rhodobacter sphaeroides (308 aa), FASTA scores: opt: 792, E(): 5.1e-35, (45.95% identity in 309 aa overlap); P38974|ETFA_PARDE ELECTRON TRANSFER FLAVOPROTEIN from Paracoccus denitrificans (307 aa), FASTA scores: opt: 789, E(): 7.4e-35, (45.95% identity in 309 aa overlap); etc. BELONGS TO THE ETF ALPHA-SUBUNIT / FIXB FAMILY.; etfA; electron transfer flavoprotein subunit alpha	complement(3387075..3388031)	Mycobacterium tuberculosis H37Rv	888549
NP_217545.1	CDS	fixA	NC_000962.2	3388070	3388870	R	Rv3029c, (MTV012.44c), len: 266 aa. Probable fixA (alternate gene name: etfB), electron transfer flavoprotein (beta-subunit). Equivalent of O33095|ETFB_MYCLE|FixA|MLCB637.03 ELECTRON TRANSFER FLAVOPROTEIN from Mycobacterium leprae (266 aa), FASTA scores: opt: 1603, E(): 7.6e-87, (95.1% identity in 266 aa overlap). Also highly similar to others e.g. Q9K417|SCG22.28c from Streptomyces coelicolor (262 aa), FASTA scores: opt: 860, E(): 2.3e-43, (52.4% identity in 263 aa overlap); O85691|ETFB_MEGEL from Megasphaera elsdenii (270 aa), FASTA scores: opt: 548, E(): 4.2e-25, (35.15% identity in 273 aa overlap); etc. Also highly similar in particular to Q9KHD0|NONH FLAVOPROTEIN REDUCTASE from Streptomyces griseus subsp. griseus (this one is required for macrotetrolide biosynthesis in Streptomyces griseus) (261 aa), FASTA scores: opt: 867, E(): 8.8e-44, (54.0% identity in 263 aa overlap). BELONGS TO THE ETF BETA-SUBUNIT / FIXA FAMILY.; etfB; electron transfer flavoprotein subunit beta	complement(3388070..3388870)	Mycobacterium tuberculosis H37Rv	887670
NP_217546.1	CDS	Rv3030	NC_000962.2	3389101	3389925	D	Rv3030, (MTV012.45), len: 274 aa. Conserved hypothetical protein, equivalent to O33094|MLCB637.02c|ML1713 hypothetical 30.8 KDa protein from Mycobacterium leprae (280 aa), FASTA scores: opt: 1388, E(): 5.5e-83, (78.2% identity in 280 aa overlap). N-terminus has similarity to hypothetical proteins from a number of organisms and to Q54303|EMBL:X86780|RAPM methyltransferase from Streptomyces hygroscopicus (317 aa), FASTA scores: opt: 191, E(): 3.6e-05, (35.65% identity in 101 aa overlap). TBparse score is 0.902.; hypothetical protein	3389101..3389925	Mycobacterium tuberculosis H37Rv	888604
NP_217547.1	CDS	Rv3031	NC_000962.2	3389922	3391502	D	Rv3031, (MTV012.46), len: 526 aa. Conserved hypothetical protein, equivalent to Q9CBR4|ML1714 HYPOTHETICAL PROTEIN from Mycobacterium leprae (522 aa), FASTA scores: opt: 3167, E(): 4.4e-190, (86.15% identity in 526 aa overlap); and highly similar to truncated O33093|MLCB637.01c HYPOTHETICAL 37.2 KDA PROTEIN (FRAGMENT) from Mycobacterium leprae (338 aa), FASTA scores: opt: 2041, E(): 5.7e-120, (84.8% identity in 342 aa overlap). Also some similarity to hypothetical proteins Q9V0M7|PAB1857 from Pyrococcus abyssi (602 aa), FASTA scores: opt: 477, E(): 3.5e-22, (31.2% identity in 556 aa overlap); and Synechocystis P74630|D90916|SLL0735 from Synechocystis sp. strain PCC 6803 (529 aa), FASTA scores: opt: 282, E(): 4.7e-10, (28.6% identity in 560 aa overlap).; hypothetical protein	3389922..3391502	Mycobacterium tuberculosis H37Rv	888543
NP_217548.1	CDS	Rv3032	NC_000962.2	3391534	3392778	D	Rv3032, (MTV012.47), len: 414 aa. Possible transferase (EC 2.-.-.-), equivalent to Q9CBR3|ML1715 PUTATIVE TRANSFERASE from Mycobacterium leprae (438 aa), FASTA scores: opt: 2456, E(): 7.3e-145, (87.9% identity in 414 aa overlap). Also similar to hypothetical proteins and various transferases e.g. P73369|SLL1971 HYPOTHETICAL 46.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (404 aa), FASTA scores: opt: 584, E(): 7.3e-29, (34.5% identity in 400 aa overlap); Q9Z5B7|SC2G5.06 PUTATIVE TRANSFERASE from Streptomyces coelicolor (406 aa), FASTA scores: opt: 509, E(): 3.3e-24, (35.9% identity in 413 aa overlap); Q9UZA1|PAB0827 GALACTOSYLTRANSFERASE (LPS BIOSYNTHESIS RFBU RELATED PROTEIN) from Pyrococcus abyssi (371 aa), FASTA scores: opt: 381, E(): 2.6e-16, (26.75% identity in 404 aa overlap); etc. TBparse score is 0.904.; transferase	3391534..3392778	Mycobacterium tuberculosis H37Rv	888185
NP_217549.1	CDS	Rv3033	NC_000962.2	3393380	3393928	D	Rv3033, (MTV012.48), len: 182 aa. Hypothetical unknown protein. TBparse score is 0.901.; hypothetical protein	3393380..3393928	Mycobacterium tuberculosis H37Rv	888865
NP_217550.1	CDS	Rv3034c	NC_000962.2	3394019	3394921	R	Rv3034c, (MTV012.49c), len: 300 aa. Possible transferase (2.-.-.-), equivalent to AAK47449|MT3119 Hexapeptide transferase family protein from M. tuberculosis strain CDC1551 but N-terminus shorter 39 residues (262 aa), FASTA scores: opt: 1773, E(): 4.7e-105, (100.0% identity in 262 aa overlap). Similar to Q9CBR1|ML1719 from Mycobacterium leprae but also shorter in N-terminus (245 aa), FASTA scores: opt: 1549, E(): 6.6e-91, (90.6% identity in 244 aa overlap). Some weakly similarity with other transferases (C-terminal part shows some similarity to acetyltransferase from Methanococcus jannaschii (214 aa)). Alternative start possible at 3395077 but codon usage not as good. TBparse score is 0.903.; transferase	complement(3394019..3394921)	Mycobacterium tuberculosis H37Rv	887470
NP_217551.1	CDS	Rv3035	NC_000962.2	3395379	3396461	D	Rv3035, (MTV012.50), len: 360 aa. Conserved hypothetical protein, equivalent to Q9CBR0|ML1720 HYPOTHETICAL PROTEIN from Mycobacterium leprae (364 aa), FASTA scores: opt: 1963, E(): 1.4e-108, (75.8% identity in 363 aa overlap). TBparse score is 0.902.; hypothetical protein	3395379..3396461	Mycobacterium tuberculosis H37Rv	887842
NP_217552.1	CDS	TB22.2	NC_000962.2	3396458	3397141	R	Rv3036c, (MTV012.51c), len: 227 aa. Probable TB22.2, conserved secreted protein, with putative N-terminal signal peptide, highly similar to secreted immunogenic protein MPT64/MPB64 P19996|Rv1980c|MTCY39.39 from Mycobacterium tuberculosis and Mycobacterium bovis (228 aa), FASTA scores: opt: 681, E(): 2.5e-35, (45.8% identity in 227 aa overlap).; hypothetical protein	complement(3396458..3397141)	Mycobacterium tuberculosis H37Rv	887320
NP_217553.1	CDS	Rv3037c	NC_000962.2	3397214	3398290	R	Rv3037c, (MTV012.52c), len: 358 aa. Conserved hypothetical protein, similar in part to others e.g. O86799|SC6G4.36c from Streptomyces coelicolor (426 aa), FASTA scores: opt: 545, E(): 5.5e-27, (36.15% identity in 354 aa overlap); Q9UZW6|PAB0687 from Pyrococcus abyssi (386 aa), FASTA scores: opt: 262, E(): 3.5e-09, (31.0% identity in 200 aa overlap).; hypothetical protein	complement(3397214..3398290)	Mycobacterium tuberculosis H37Rv	888640
NP_217554.1	CDS	Rv3038c	NC_000962.2	3398425	3399408	R	Rv3038c, (MTV012.53c), len: 327 aa. Conserved hypothetical protein, equivalent to Q9CBQ9|ML1723 HYPOTHETICAL PROTEIN from Mycobacterium leprae (327 aa), FASTA scores: opt: 1843, E(): 6.1e-108, (80.75% identity in 327 aa overlap). Weak similarity with e.g. Q9KZI3|SCG8A.16 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (199 aa), FASTA scores: opt: 227, E(): 3.9e-07, (31.95% identity in 191 aa overlap) and O52570 METHYLTRANSFERASE from Amycolatopsis mediterranei (272 aa), FASTA scores: opt: 228, E(): 4.3e-07, (31.7% identity in 164 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature but shows no similarity to known LysR family members. TBparse score is 0.899.; hypothetical protein	complement(3398425..3399408)	Mycobacterium tuberculosis H37Rv	888517
NP_217555.1	CDS	echA17	NC_000962.2	3399419	3400183	R	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	complement(3399419..3400183)	Mycobacterium tuberculosis H37Rv	888216
NP_217556.1	CDS	Rv3040c	NC_000962.2	3400192	3401058	R	Rv3040c, (MTV012.55c), len: 288 aa. Conserved hypothetical protein, highly similar to Q9XA40|SCH17.07c hypothetical protein from Streptomyces coelicolor (312 aa), FASTA scores: opt: 648, E(): 5.2e-34, (50.0% identity in 260 aa overlap). Also similar to Q9F7R7 PREDICTED MUTT SUPERFAMILY HYDROLASE from uncultured proteobacterium EBAC31A08 (264 aa), FASTA scores: opt: 295, E(): 1.3e-11, (27.2% identity in 257 aa overlap); AAK24293|CC2322 hypothetical protein from Caulobacter crescentus (254 aa), BLAST scores: 185 (32% identity) AND 131 (37% identity), etc.; hypothetical protein	complement(3400192..3401058)	Mycobacterium tuberculosis H37Rv	887672
NP_217557.1	CDS	Rv3041c	NC_000962.2	3401055	3401918	R	Rv3041c, (MTV012.56c), len: 287 aa. Probable conserved ATP-binding protein ABC transporter (see citation below), equivalent to Q9CBQ7|ML1726 PUTATIVE ABC TRANSPORTER PROTEIN ATP-BINDING PROTEIN from Mycobacterium leprae (305 aa), FASTA scores: opt: 1576, E(): 8.6e-85, (83.4% identity in 289 aa overlap). Also similar to other putative ATP-binding proteins ABC transporters e.g. Q9X9Z4|SCI5.06C from Streptomyces coelicolor (265 aa), FASTA scores: opt: 893, E(): 4.8e-45, (53.3% identity in 257 aa overlap); Q9L156|SC5C11.16c from Streptomyces coelicolor (279 aa), FASTA scores: opt: 680, E(): 1.3e-32, (45.4% identity in 271 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.901.; ABC transporter ATP-binding protein	complement(3401055..3401918)	Mycobacterium tuberculosis H37Rv	887197
NP_217558.1	CDS	serB2	NC_000962.2	3401933	3403162	R	Rv3042c, (MTV012.57c), len: 409 aa. Probable serB2, Phosphoserine phosphatase (EC 3.1.3.3), equivalent to Q9CBQ6|ML1727 PUTATIVE PHOSPHOSERINE PHOSPHATASE from Mycobacterium leprae (411 aa), FASTA scores: opt: 2173, E(): 1.3e-117, (86.3% identity in 408 aa overlap). Also similar to other e.g. Q9S281|SCI28.02 from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1209, E(): 3e-62, (51.75% identity in 400 aa overlap); Q9HUK|PA4960 from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 704, E(): 3.1e-33, (40.95% identity in 393 aa overlap); O28142|SERB_ARCTU|AF2138 from Archaeoglobus fulgidus (344 aa), FASTA scores: opt: 671, E(): 2e-31, (37.25% identity in 325 aa overlap); and P06862|SERB_ECOLI (322 aa), FASTA scores: opt: 628, E(): 5.7e-29, (46.8% identity in 235 aa overlap). BELONGS TO THE SERB FAMILY. TBparse score is 0.884.; phosphoserine phosphatase	complement(3401933..3403162)	Mycobacterium tuberculosis H37Rv	887815
NP_217559.1	CDS	ctaD	NC_000962.2	3403200	3404921	R	Rv3043c, (MTV012.58c), len: 573 aa. Probable ctaD, integral membrane cytochrome C oxidase polypeptide I (EC 1.9.3.1), equivalent to Q9CBQ5|ML1728 from Mycobacterium leprae (574 aa), FASTA scores: opt: 3738, E(): 3.8e-216, (95.4% identity in 566 aa overlap). Also similar to other CYTOCHROME C OXIDASES POLYPEPTIDE I e.g. Q9AEL9|CTAD from Corynebacterium glutamicum (Brevibacterium flavum) (584 aa), FASTA scores: opt: 3065, E(): 6.8e-176, (72.65% identity in 567 aa overlap); Q9X813|SC6G10.28c from Streptomyces coelicolor (578 aa), FASTA scores: opt: 2888, E(): 2.6e-165, (71.7% identity in 544 aa overlap); Q9K451|CTAD from Streptomyces coelicolor (573 aa), FASTA scores: opt: 2757, E(): 1.8e-157, (70.2% identity in 537 aa overlap). Contains PS00077 Cytochrome c oxidase subunit I, copper B binding region signature. BELONGS TO THE HEME-COPPER RESPIRATORY OXIDASE FAMILY. TBparse score is 0.903.; cytochrome C oxidase polypeptide I	complement(3403200..3404921)	Mycobacterium tuberculosis H37Rv	887881
NP_217560.1	CDS	fecB	NC_000962.2	3405136	3406215	D	Rv3044, (MTV012.59), len: 359 aa. Probable fecB, FeIII dicitrate-binding periplasmic lipoprotein (see citation below), equivalent to Q9CBQ4|FECB|ML1729 PUTATIVE FEIII-DICITRATE TRANSPORTER LIPOPROTEIN from Mycobacterium leprae (364 aa), FASTA scores: opt: 1816, E(): 1.1e-96, (75.65% identity in 357 aa overlap); and Q9LA57|FECB from Mycobacterium avium (364 aa), FASTA scores: opt: 1769, E(): 5.1e-94. Similar to many periplasmic FeIII-dicitrate transporters e.g. P72593|FECB|SLR1319 from Synechocystis sp. strain PCC 6803 (315 aa), FASTA scores: opt: 459, E(): 3.6e-19, (31.35% identity in 303 aa overlap); and P72611|FECB|SLR1492 from Synechocystis sp. strain PCC 6803. N-terminus longer (approximatively 30 aa) to AAK47459 from Mycobacterium tuberculosis strain CDC1551 (327 aa). Has signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.883.; FEIII-dicitrate-binding periplasmic lipoprotein	3405136..3406215	Mycobacterium tuberculosis H37Rv	888745
NP_217561.1	CDS	adhC	NC_000962.2	3406285	3407325	D	Rv3045, (MTV012.60), len: 346 aa. Probable adhC, NADP-dependent alcohol dehydrogenase (EC 1.1.1.2), equivalent to Q9CBQ3|ADHA|ML1730 ALCOHOL DEHYDROGENASES from Mycobacterium leprae (362 aa), FASTA scores: opt: 1982, E(): 1.3e-111, (85.85% identity in 346 aa overlap); Q9AE96|ADHC from Mycobacterium smegmatis (348 aa), FASTA scores: opt: 1808, E(): 3.4e-101, (78.95% identity in 347 aa overlap); Q9EWF1|SCK13.33c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (346 aa), FASTA scores: opt: 1508, E(): 3.3e-83, (64.45% identity in 346 aa overlap); O06007|ADHA from Bacillus subtilis (349 aa), FASTA scores: opt: 1412, E(): 1.9e-77, (61.8% identity in 335 aa overlap); etc. Contains PS00059 Zinc-containing alcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY. HIGH SIMILARITY WITH OTHER BACTERIAL ADH'S. TBparse score is 0.878.; NADP-dependent alcohol dehydrogenase ADHC	3406285..3407325	Mycobacterium tuberculosis H37Rv	888888
NP_217562.1	CDS	Rv3046c	NC_000962.2	3407314	3407688	R	Rv3046c, (MTV012.61c), len: 124 aa. Conserved hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. Q50171|ML2258 U296W HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa), FASTA scores: opt: 194, E(): 7.6e-06, (35.9% identity in 103 aa overlap); and O06409|Rv0543c|MTCY25D10.22c from Mycobacterium tuberculosis (100 aa), FASTA scores: opt: 192, E(): 1e-05, (34.7% identity in 98 aa overlap). TBparse score is 0.873.; hypothetical protein	complement(3407314..3407688)	Mycobacterium tuberculosis H37Rv	888870
NP_217563.1	CDS	Rv3047c	NC_000962.2	3408022	3408306	R	Rv3047c, (MTV012.62c), len: 94 aa. Hypothetical unknown protein.; hypothetical protein	complement(3408022..3408306)	Mycobacterium tuberculosis H37Rv	888898
YP_177921.1	CDS	nrdF2	NC_000962.2	3408404	3409378	R	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta	complement(3408404..3409378)	Mycobacterium tuberculosis H37Rv	888886
NP_217565.1	CDS	Rv3049c	NC_000962.2	3409509	3411083	R	Rv3049c, (MTV012.64c), len: 524 aa. Probable monooxygenase (EC 1.-.-.-), similar to several monooxygenases e.g. Q9I3H5|PA1538 PROBABLE FLAVIN-CONTAINING MONOOXYGENASE from Pseudomonas aeruginosa (527 aa), FASTA scores: opt: 1577, E(): 3.9e-90, (47.3% identity in 501 aa overlap); Q9RKB5|SCE87.23c MONOOXYGENASE from Streptomyces coelicolor (519 aa), FASTA scores: opt: 1522, E(): 9.8e-87, (47.4% identity in 485 aa overlap); Q9I218|PA2097 PROBABLE FLAVIN-BINDING MONOOXYGENASE from Pseudomonas aeruginosa (491 aa), FASTA scores: opt: 1366, E(): 4.2e-77, (43.75% identity in 489 aa overlap); etc. Also similar to Q10532|Rv0892|Y892_MYCTU|MT0916|MTCY31.20 PROBABLE MONOOXYGENASE (EC 1.14.13.-) from Mycobacterium tuberculosis strain H37Rv (495 aa), FASTA scores: opt: 1147, E(): 1.5e-63, (38.0% identity in 479 aa overlap). TBparse score is 0.897.; monooxygenase	complement(3409509..3411083)	Mycobacterium tuberculosis H37Rv	888894
NP_217566.1	CDS	Rv3050c	NC_000962.2	3411217	3411957	R	Rv3050c, (MTV012.65c), len: 246 aa. Probable transcriptional regulatory protein tetR-family, equivalent but shorter to Q9CBQ1|ML1733 from Mycobacterium leprae (275 aa), FASTA scores: opt: 1381,(E): 2.7e-79, (86.25% identity in 240 aa overlap); AAK44712|MT0489 from Mycobacterium tuberculosis strain CDC1551 (256 aa), FASTA scores: opt: 328,(E): 1.8e-13, (30.75% identity in 234 aa overlap); etc. Also some similarity to O53757|Rv0472c|MTV038.16c. Alternative starts possible at 68052 or 67923. Has potential helix-turn-helix motif at positons 51-72.; AsnC family transcriptional regulator	complement(3411217..3411957)	Mycobacterium tuberculosis H37Rv	888866
NP_217567.1	CDS	nrdE	NC_000962.2	3412085	3414166	R	Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha	complement(3412085..3414166)	Mycobacterium tuberculosis H37Rv	888869
NP_217568.1	CDS	nrdI	NC_000962.2	3414232	3414684	R	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein	complement(3414232..3414684)	Mycobacterium tuberculosis H37Rv	888885
NP_217569.1	CDS	nrdH	NC_000962.2	3414719	3414958	R	Rv3053c, (MTCY22D7.29), len: 79 aa. Probable nrdH, glutaredoxin-like protein, equivalent to Q9CBP8|NRDH|ML1736 from Mycobacterium leprae (80 aa), FASTA scores: opt: 478, E(): 2.7e-27, (91.15% identity in 79 aa overlap), and similar to many glutaredoxin-like proteins e.g. Q9XD65|NRDH from Corynebacterium glutamicum (Brevibacterium flavum) (77 aa), FASTA scores: opt: 382, E(): 1.5e-20, (72.35% identity in 76 aa overlap); and Q56108|NRDH_SALTY from Salmonella typhimurium (81 aa), FASTA scores: opt: 243, E(): 9.9e-11, (45.85% identity in 72 aa overlap). BELONGS TO THE GLUTAREDOXIN FAMILY.; glutaredoxin electron transport protein NrdH	complement(3414719..3414958)	Mycobacterium tuberculosis H37Rv	888884
NP_217570.1	CDS	Rv3054c	NC_000962.2	3415435	3415989	R	Rv3054c, (MTCY22D7.28), len: 184 aa. Conserved hypothetical protein, similar to Q9RD22|SCM1.21 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (187 aa), FASTA scores: opt: 651, E(): 1.5e-33, (56.8% identity in 175 aa overlap). Also shares similarity with other hypothetical proteins and Chromate reductases e.g. AAK56853|CHRR from Pseudomonas putida (186 aa), FASTA scores: opt: 339, E(): 3.3e-14, (38.75% identity in 160 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599) near C-terminus. TBparse score is 0.873.; hypothetical protein	complement(3415435..3415989)	Mycobacterium tuberculosis H37Rv	887963
NP_217571.1	CDS	Rv3055	NC_000962.2	3416081	3416695	D	Rv3055, (MTCY22D7.26c), len: 204 aa. Possible transcriptional regulatory protein, similar to Q9RD23|SCM1.20c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (234 aa), FASTA scores: opt: 471, E(): 4.6e-23, (44.9% identity in 187 aa overlap); and with low similarity to other e.g. Q9ADK8|2SCK31.12 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (198 aa), FASTA scores: opt: 208, 2.5e-06, (32.9% identity in 155 aa overlap); Q9ADD9|SCBAC20F6.11c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (199 aa), FASTA scores: opt: 182, E(): 0.00012, (31.0% identity in 184 aa overlap). Contains potential helix-turn-helix motif from aa 48 to 69 (+3.42 SD). SO MAY BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.; TetR family transcriptional regulator	3416081..3416695	Mycobacterium tuberculosis H37Rv	888882
NP_217572.1	CDS	dinP	NC_000962.2	3416705	3417745	D	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV	3416705..3417745	Mycobacterium tuberculosis H37Rv	887519
NP_217573.1	CDS	Rv3057c	NC_000962.2	3417799	3418662	R	Rv3057c, (MTCY22D7.24), len: 287 aa. Probable oxidoreductase, probably short-chain alcohol dehydrogenase/reductase (EC 1.1.-.-). Equivalent to Q9CBP7|ML1740 POSSIBLE SHORT CHAIN DEHYDROGENASES/REDUCTASE from Mycobacterium leprae (312 aa), FASTA scores: opt: 1563, E(): 6e-89, (81.8% identity in 280 aa overlap). Also similar to many oxidoreductases e.g. Q9ZBX8|SCD78.21c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (585 aa), FASTA scores: opt: 541, E(): 6.7e-26, (37.25% identity in 263 aa overlap); AAK47506|MT3170 OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY from Mycobacterium tuberculosis strain CDC1551 (276 aa), FASTA scores: opt: 521, E(): 6.1e-25, (36.25% identity in 276 aa overlap); AAK45541|MT1283 OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY from Mycobacterium tuberculosis strain CDC1551 (276 aa), FASTA scores: opt: 471, E(): 7.2e-22, (32.4% identity in 281 aa overlap). Also similar to O50460|Rv1245c|MTV006.17C DEHYDROGENASE (276 aa). Contains short-chain alcohol dehydrogenase family signature (PS00061). MAY BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is 0.925.; short chain dehydrogenase	complement(3417799..3418662)	Mycobacterium tuberculosis H37Rv	888617
NP_217574.1	CDS	Rv3058c	NC_000962.2	3418726	3419376	R	Rv3058c, (MTCY22D7.23), len: 216 aa. Possible transcriptional regulatory protein, tetR-family, showing reasonable similarity to others e.g. AAK48337|MT3970 from Mycobacterium tuberculosis strain CDC1551 (216 aa), FASTA scores: opt: 261, E(): 2.8e-10, (31.7% identity in 221 aa overlap); Q49962|ML1070|U1756B from Mycobacterium leprae (217 aa), FASTA scores: opt: 234, E(): 1.8e-08, (27.2% identity in 195 aa overlap); Q9CDD3|ML0064 from Mycobacterium leprae (214 aa), FASTA scores: opt: 199, E(): 3.6e-06, (25.65% identity in 195 aa overlap); O66121|CPRS from Streptomyces coelicolor (215 aa), FASTA scores: opt: 183, E(): 4.2e-05, (26.0% identity in 196 aa overlap). Equivalent to AAK47476|MT3144 from Mycobacterium tuberculosis strain CDC1551 (237 aa) but N-terminus shorter 21 residues. Start was predicted by TBparse but alternatives (ATG) are possible. COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.913.; TetR family transcriptional regulator	complement(3418726..3419376)	Mycobacterium tuberculosis H37Rv	888878
NP_217575.1	CDS	cyp136	NC_000962.2	3419492	3420970	D	Rv3059, (MTCY22D7.22c), len: 492 aa. Probable cyp136, cytochrome P450 136 (EC 1.14.-.-), similar to other cytochrome P450-dependent oxidases e.g. Q59990|CYP120|CYP|SLR0574 PUTATIVE CYTOCHROME P450 120 from Synechocystis sp. strain PCC 6803 (444 aa), FASTA scores: opt: 579, E(): 1.5e-29, (27.3% identity in 443 aa overlap); Q64654|CYP51|CP51_RAT CYTOCHROME P450 51 (EC 1.14.14.-) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Rattus norvegicus (Rat) (503 aa), FASTA scores: opt: 549, E(): 1.4e-27, (26.2% identity in 458 aa overlap); Q9JIY3|CYP51 LANOSTEROL 14-ALPHA-DEMETHYLASE from Mus musculus (Mouse) (486 aa), FASTA scores: opt: 546, E(): 2.1e-27, (25.75% identity in 458 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY. TBparse score is 0.903.; cytochrome P450 136	3419492..3420970	Mycobacterium tuberculosis H37Rv	888883
NP_217576.1	CDS	Rv3060c	NC_000962.2	3421741	3423213	R	Rv3060c, (MTCY22D7.21), len: 490 aa. Probable transcriptional regulatory protein, showing reasonable similarity to several members of the GntR family e.g. BAB54431|MLL8575 from Rhizobium loti (Mesorhizobium loti) (247 aa), FASTA scores: opt: 274, E(): 3.5e-10, (30.35% identity in 224 aa overlap); P96570|ESMR from Burkholderia cepacia (Pseudomonas cepacia) (277 aa), FASTA scores: opt: 229, E(): 2.8e-07, (25.85% identity in 240 aa overlap); Q9S276|SCI28.07 from Streptomyces coelicolor (230 aa), FASTA scores: opt: 211, E(): 3.4e-06, (27.25% identity in 220 aa overlap); etc. Seems to have two domains: residues 1-260 resemble UxuR, and 260-490 resemble PdhR, ExuR, etc. Contains bacterial regulatory proteins, GntR family signature (PS00043). Helix-turn-helix motif (+3.13 SD) at aa 38-59. SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL REGULATORS.; GntR family transcriptional regulator	complement(3421741..3423213)	Mycobacterium tuberculosis H37Rv	888855
NP_217577.1	CDS	fadE22	NC_000962.2	3423262	3425427	R	Rv3061c, (MTCY22D7.20), len: 721 aa. Probable fadE22, Acyl-CoA Dehydrogenase (EC 1.3.99.-), similar to many e.g. AAK44503|MT0284 from Mycobacterium tuberculosis strain CDC1551 (731 aa), FASTA scores: opt: 1804, E(): 1.1e-101, (43.45% identity in 743 aa overlap); AAK48037|MT3678 from Mycobacterium tuberculosis strain CDC1551 (711 aa), FASTA scores: opt: 1630, E(): 3.9e-91, (42.55% identity in 733 aa overlap); and extensive similarity in C-terminal part to many acyl-CoA dehydrogenases e.g. Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 767, E(): 4.8e-39, (36.7% identity in 376 aa overlap). Also similar to many hypothetical proteins. COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY. TBparse score is 0.901.; acyl-CoA dehydrogenase FADE22	complement(3423262..3425427)	Mycobacterium tuberculosis H37Rv	887617
NP_217578.1	CDS	ligB	NC_000962.2	3425584	3427107	D	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; ATP-dependent DNA ligase	3425584..3427107	Mycobacterium tuberculosis H37Rv	887553
NP_217579.1	CDS	cstA	NC_000962.2	3427243	3429519	D	Rv3063, (MTCY22D7.18c), len: 758 aa. Probable cstA, integral membrane starvation-induced stress response protein, similar to other e.g. P15078|CSTA_ECOLI|B0598 from Escherichia coli strain K12 (701 aa), FASTA scores: opt: 2357, E(): 9.5e-137, (51.25% identity in 712 aa overlap); AAG54933|CSTA from Escherichia coli strain O157:H7 EDL933 (701 aa), FASTA scores: opt: 2356, E(): 1.1e-136, (51.1% identity in 712 aa overlap); etc. Predicted to be membrane associated. Similarity suggests start at GTG at 16801 in Y22D7 but no RBS obvious so TBparse-predicted start at 16881 taken. BELONGS TO THE CSTA FAMILY. TBparse score is 0.907.; carbon starvation protein A CstA	3427243..3429519	Mycobacterium tuberculosis H37Rv	887948
NP_217580.1	CDS	Rv3064c	NC_000962.2	3429825	3430250	R	Rv3064c, (MTCY22D7.17), len: 141 aa. Probable conserved integral membrane protein, similar to many e.g. Q9KY40|SCC8A.08 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 391, E(): 2.4e-18, (48.45% identity in 130 aa overlap); Q9K461|SC2H12.23c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 339, E(): 5.1e-15, (46.7% identity in 124 aa overlap); BAB48975|MLR1652 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (130 aa), FASTA scores: opt: 319, E(): 8.7e-14, (41.45% identity in 123 aa overlap); Q9JR31|NMA2196|NMB0291 CONSERVED HYPOTHETICAL INNER MEMBRANE PROTEIN from Neisseria meningitidis serogroup A and B (132 aa), FASTA scores: opt: 303, E(): 9.4e-13, (43.65% identity in 126 aa overlap); etc.; integral membrane protein	complement(3429825..3430250)	Mycobacterium tuberculosis H37Rv	888879
YP_177922.1	CDS	mmr	NC_000962.2	3430387	3430710	D	Rv3065, (MT3150.1, MTCY22D7.17c), len: 107 aa. mmr, integral membrane multidrugs resistance transporter (see citation below), equivalent to Q9CBP1|ML1756 PROBABLE MULTIDRUG RESISTANCE PROTEIN from Mycobacterium leprae (107 aa), FASTA scores: opt: 534, E(): 3.3e-28, (77.55% identity in 107 aa overlap). Also highly similar to bacterial proteins involved in resistance to ethidium bromide or methyl viologen e.g. O87866|QACG_STASP QUATERNARY AMMONIUM COMPOUND-RESISTANCE PROTEIN QACG (QUARTERNARY AMMONIUM DETERMINANT G) from Staphylococcus sp. strain ST94 (107 aa), FASTA scores: opt: 307, E(): 1.8e-13, (39.8% identity in 103 aa overlap); P96460|QAC QUATERNARY AMMONIUM COMPOUNDS RESISTANCE PROTEIN QAC from Staphylococcus aureus (107 aa), FASTA scores: opt: 304, E(): 2.8e-13, (40.4% identity in 104 aa overlap); Q57225|QACE_ECOLI QUATERNARY AMMONIUM COMPOUND-RESISTANCE PROTEIN QACE (QUARTERNARY AMMONIUM DETERMINANT E) from Escherichia coli (110 aa), FASTA scores: opt: 300, E(): 5.2e-13, (48.15% identity in 108 aa overlap); AAG55967|Z1870 METHYLVIOLOGEN RESISTANCE PROTEIN ENCODED WITHIN PROPHAGE CP-933X from Escherichia coli strain O157:H7 EDL933 (110 aa); P23895|EMRE|MVRC|EB|B0543 EMRE PROTEIN from Escherichia coli (110 aa), FASTA scores: opt: 290, E(): 2.3e-12, (43.55% identity in 101 aa overlap); etc. Also similar to the SugE protein of enteric bacteria. BELONGS TO THE SMALL MULTIDRUG RESISTANCE (SMR) PROTEIN FAMILY. Note that previously known as emrE.; emrE; multidrugs-transport integral membrane protein MMR	3430387..3430710	Mycobacterium tuberculosis H37Rv	887550
NP_217582.1	CDS	Rv3066	NC_000962.2	3430707	3431315	D	Rv3066, (MTCY22D7.15c), len: 202 aa. Probable transcriptional regulatory protein deoR-family, with some similarity to transcriptional regulators and hypothetical proteins, e.g. Q9X9V5|SCI7.35c HYPOTHETICAL 21.1 KDA PROTEIN from Streptomyces coelicolor (197 aa), FASTA scores: opt: 398, E(): 5.7e-19, (40.3% identity in 191 aa overlap); AAG55222|Z1073 PUTATIVE DEOR-TYPE TRANSCRIPTIONAL REGULATOR from Escherichia coli strain O157:H7 EDL933 (178 aa), FASTA scores: opt: 257, E(): 7.9e-10, (28.4% identity in 176 aa overlap); Q9HXU1|PA3699 PROBABLE TRANSCRIPTIONAL REGULATOR (TETR/ACRR FAMILY) from Pseudomonas aeruginosa (237 aa), FASTA scores: opt: 229, E(): 6.7e-08, (32.1% identity in 187 aa overlap); etc.; DeoR family transcriptional regulator	3430707..3431315	Mycobacterium tuberculosis H37Rv	888847
NP_217583.1	CDS	Rv3067	NC_000962.2	3431428	3431838	D	Rv3067, (MTCY22D7.14c), len: 136 aa. Conserved hypothetical protein, weakly similar to other mycobacterium proteins e.g. O53953|Rv1804c|MTV049.26c (108 aa), FASTA scores: opt: 183, E(): 0.00053, (36.6% identity in 82 aa overlap); O07222|Rv1810|MTCY16F9.04c (118 aa), FASTA scores: opt: 149, E(): 0.05, (30.95% identity in 84 aa overlap). Has hydrophobic stretch at N-terminus. Start chosen on basis of codon usage but upstream ATG also possible.; hypothetical protein	3431428..3431838	Mycobacterium tuberculosis H37Rv	888822
NP_217584.1	CDS	pgmA	NC_000962.2	3431979	3433622	R	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase	complement(3431979..3433622)	Mycobacterium tuberculosis H37Rv	888826
NP_217585.1	CDS	ccrB	NC_000962.2	3433692	3434090	D	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB	3433692..3434090	Mycobacterium tuberculosis H37Rv	888859
NP_217586.1	CDS	ccrB	NC_000962.2	3434087	3434467	D	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB	3434087..3434467	Mycobacterium tuberculosis H37Rv	888651
NP_217587.1	CDS	Rv3071	NC_000962.2	3434464	3435573	D	Rv3071, (MTCY22D7.10c), len: 369 aa. Conserved hypothetical protein, weakly similar in N-terminus of Q9A4V0|CC2725 HYPOTHETICAL PROTEIN CC2725 from Caulobacter crescentus (113 aa), FASTA scores: opt: 141, E(): 0.031, (27.6% identity in 105 aa overlap). C-terminal region also weakly similar to other hypothetical proteins e.g. Q9FC38|YG11_STRCO from Streptomyces coelicolor (114 aa), FASTA scores: opt: 151, E(): 0.007, (31.65% identity in 98 aa overlap). TBparse score is 0.912.; hypothetical protein	3434464..3435573	Mycobacterium tuberculosis H37Rv	888649
NP_217588.1	CDS	Rv3072c	NC_000962.2	3435798	3436322	R	Rv3072c, (MTCY22D7.09), len: 174 aa. Hypothetical protein, similar in part to O87779 HYPOTHETICAL 18.1 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (166 aa), FASTA scores: opt: 238, E(): 2.5e-08, (42.6% identity in 108 aa overlap); Q9AH10 PUTATIVE F420-DEPENDENT DEHYDROGENASE from Rhodococcus erythropolis (295 aa), FASTA scores: opt: 228, E(): 1.7e-07, (34.25% identity in 111 aa overlap); P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 POSSIBLE OXIDOREDUCTASE from Mycobacterium tuberculosis strain H37Rv (304 aa), FASTA scores: opt: 208, E(): 3.2e-06, (38.9% identity in 108 aa overlap); etc. N-terminal region similar to several proteins from Mycobacterium tuberculosis (see MAST results on the web site http://www.genolist.pasteur.fr/TubercuList/mast/P18.1.htm l) . TBparse score is 0.976.; hypothetical protein	complement(3435798..3436322)	Mycobacterium tuberculosis H37Rv	887175
NP_217589.1	CDS	Rv3073c	NC_000962.2	3436329	3436685	R	Rv3073c, (MTCY22D7.08), len: 118 aa. Conserved hypothetical protein, highly similar to other e.g. Q9F3D7|SC2H2.18 from Streptomyces coelicolor (119 aa), FASTA scores: opt: 399, E(): 2.5e-20, (53.05% identity in 115 aa overlap); Q9K4K9|SC5F8.15c from Streptomyces coelicolor (117 aa), FASTA scores: opt: 334, E(): 6e-16, (49.1% identity in 112 aa overlap); Q9HKD5|TA0666 from Thermoplasma acidophilum (134 aa), FASTA scores: opt: 334, E(): 6.7e-16, (42.35% identity in 111 aa overlap); BAB53507|MLL7394 from Rhizobium loti (Mesorhizobium loti) (120 aa), FASTA scores: opt: 309, E(): 3e-14, (43.65% identity in 110 aa overlap); etc. TBparse score is 0.885.; hypothetical protein	complement(3436329..3436685)	Mycobacterium tuberculosis H37Rv	888647
NP_217590.1	CDS	Rv3074	NC_000962.2	3436779	3438053	D	Rv3074, (MTCY22D7.07c), len: 424 aa. Conserved hypothetical protein, highly similar but shorter (46 aa) to P71806|Rv1378c|MTCY02B12.12c HYPOTHETICAL 51.3 KDA PROTEIN from Mycobacterium tuberculosis (475 aa), FASTA scores: opt: 2009, E(): 5.8e-113, (72.95% identity in 429 aa overlap); and also similar to other hypothetical mycobacterium proteins e.g. O33266|Rv0336|MTCY279.03 (503 aa), FASTA scores: opt: 337, E(): 7.5e-13, (28.6% identity in 381 aa overlap); O33360|Rv0515|MTCY20G10.05 (503 aa), FASTA scores: opt: 337, E(): 7.5e-13, (28.6% identity in 381 aa overlap); etc. TBparse score is 0.910.; hypothetical protein	3436779..3438053	Mycobacterium tuberculosis H37Rv	888027
NP_217591.1	CDS	Rv3075c	NC_000962.2	3438050	3438973	R	Rv3075c, (MTCY22D7.06), len: 307 aa. Conserved hypopthetical protein, with some similarity to Q9I562|PA0883 PROBABLE ACYL-CoA LYASE BETA CHAIN from Pseudomonas aeruginosa (275 aa), FASTA scores: opt: 408, E(): 9.2e-19, (35.15% identity in 273 aa overlap); Q9S2U9|SC4G6.02 PUTATIVE CITRATE LYASE BETA CHAIN from Streptomyces coelicolor (274 aa), FASTA scores: opt: 384, E(): 3.1e-17, (34.7% identity in 265 aa overlap); O06162|CITE|Rv2498c|MTCY07A7.04c from Mycobacterium tuberculosis (273 aa), FASTA scores: opt: 349, E(): 5.1e-15, (35.2% identity in 264 aa overlap); etc. Several initiation codons possible, first one chosen. TBparse score is 0.920.; hypothetical protein	complement(3438050..3438973)	Mycobacterium tuberculosis H37Rv	887178
NP_217592.1	CDS	Rv3076	NC_000962.2	3439072	3439548	D	Rv3076, (MTCY22D7.05c), len: 158 aa. Conserved hypothetical protein, weakly similar to Q9AK12|SC8D11.07 HYPOTHETICAL 17.0 KDA PROTEIN from Streptomyces coelicolor (151 aa), FASTA scores: opt: 110, E(): 1.5, (25.5% identity in 145 aa overlap).; hypothetical protein	3439072..3439548	Mycobacterium tuberculosis H37Rv	888026
YP_177923.1	CDS	Rv3077	NC_000962.2	3439541	3441352	D	Rv3077, (MTCY22D7.04c), len: 603 aa. Possible hydrolase (EC 3.1.-.-), with some similarity to variety of hydrolases (aryl- and steryl sulfatases principaly) e.g. Q45087|PEHA PHOSPHONATE MONOESTER HYDROLASE from Burkholderia caryophylli (514 aa), FASTA scores: opt: 239, E(): 7.2e-07, (23.95% identity in 413 aa overlap); Q9I1E5|PA2333 PROBABLE SULFATASE from Pseudomonas aeruginosa (538 aa), FASTA scores: opt: 231, E(): 2.3e-06, (28.1% identity in 516 aa overlap); P31447|YIDJ_ECOLI|B3678 PUTATIVE SULFATASE (EC 3.1.6.-) from Escherichia coli (497 aa), FASTA scores: opt: 222, E(): 7.4e-06, (27.7% identity in 390 aa overlap); etc. TBparse score is 1.002. Note that previously known as atsF.; atsF; hydrolase	3439541..3441352	Mycobacterium tuberculosis H37Rv	887419
NP_217594.1	CDS	hab	NC_000962.2	3441353	3441754	D	Rv3078, (MTCY22D7.03c), len: 133 aa. Probable hab, hydroxylaminobenzene mutase (5.-.-.-) (see Davis et al., 2000), highly similar to two hydroxylaminobenzene mutases from Pseudomonas pseudoalcaligenes O52214|HABA (135 aa), FASTA scores: opt: 495, E(): 6.8e-25, (51.1% identity in 133 aa overlap); and O52216|HABB (164 aa), FASTA scores: opt: 479, E(): 8.2e-24, (51.9% identity in 133 aa overlap) (see Davis et al., 2000); and to Q9AH35|NBZB HYDROXYLAMINOBENZENE MUTASE from Pseudomonas putida (164 aa), FASTA scores: opt: 476, E(): 1.3e-23, (51.8% identity in 133 aa overlap) (see Park & Kim 2000). Gene name according to Pseudomonas pseudoalcaligenes nomenclature. Also similarity with putative different membrane proteins involved in transport (protein predicted to be a transmembrane protein). TBparse score is 0.870.; hydroxylaminobenzene mutase HAB	3441353..3441754	Mycobacterium tuberculosis H37Rv	888891
NP_217595.1	CDS	Rv3079c	NC_000962.2	3441770	3442597	R	Rv3079c, (MTCY22D7.02), len: 275 aa. Conserved hypothetical protein, similar to other hypothetical mycobacterium proteins e.g. P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 POSSIBLE OXIDOREDUCTASE from Mycobacterium tuberculosis strain H37Rv (282 aa), FASTA scores: opt: 668, E(): 2.4e-34, (40.55% identity in 281 aa overlap); O06216|Rv2161c|MTCY270.07 from Mycobacterium tuberculosis strain H37Rv (288 aa), FASTA scores: opt: 595, E(): 8.5e-30, (40.9% identity in 274 aa overlap); O87779 from Mycobacterium paratuberculosis (166 aa), FASTA scores: opt: 464, E(): 7.2e-22, (41.55% identity in 166 aa overlap); etc. Also some similarity to other proteins e.g. Q9AH10 PUTATIVE F420-DEPENDENT DEHYDROGENASE from Rhodococcus erythropolis (295 aa), FASTA scores: opt: 401, E(): 9.6e-18, (30.2% identity in 288 aa overlap); Q9AE04|RIF17 RIF17 PROTEIN from Amycolatopsis mediterranei (356 aa), FASTA scores: opt: 298, E(): 2.8e-11, (35.0% identity in 203 aa overlap); AAK48081|MT3720 LUCIFERASE-RELATED PROTEIN from Mycobacterium tuberculosis strain CDC1551 (395 aa), FASTA scores: opt: 223, E(): 1.4e-06, (29.4% identity in 211 aa overlap). TBparse score is 0.916.; hypothetical protein	complement(3441770..3442597)	Mycobacterium tuberculosis H37Rv	888660
NP_217596.1	CDS	pknK	NC_000962.2	3442656	3445988	R	Rv3080c, (MTV013.01c-MTCY22D7.01), len: 1110 aa. Probable pknK, serine/threonine protein kinase involved in transcriptional regulatory function (EC 2.7.1.-) (see citation below). Similar but shorter in N-terminus (approximatively 300 residues) to others e.g. Q48411|ACOK TRANSCRIPTIONAL REGULATORY PROTEIN OF aco ABCD operon from Klebsiella pneumoniae (921 aa), FASTA scores: opt: 886, E(): 7.6e-37, (27.75% identity in 829 aa overlap); Q9HX92|PA3921 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (906 aa), FASTA scores: opt: 760, E(): 1.5e-30, (29.55% identity in 822 aa overlap); Q9I2X9|PA1760 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (907 aa), FASTA scores: opt: 696, E(): 2.3e-27, (25.85% identity in 685 aa overlap); P06993|MALT (alias BAB37683|ECS4260 and AAG58520|MALT) POSITIVE REGULATOR OF MAL REGULON from Escherichia coli strain O157:H7 (901 aa), FASTA scores: opt: 660, E(): 1.4e-25, (29.25% identity in 530 aa overlap); Q9KNF3|VCA0011 MALT REGULATORY PROTEIN from Vibrio cholerae (BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS) (921 aa), FASTA scores: opt: 626, E(): 7.2e-24, (25.8% identity in 659 aa overlap); etc. N-terminal region similar to N-terminus of serine/threonine kinases e.g. Q9KK90|PKMA SERINE/THREONINE KINASE (SIMILAR TO THE SER/THR FAMILY OF PROTEIN KINASES) from Amycolatopsis mediterranei (589 aa), FASTA scores: opt: 545, E(): 5.7e-20, (34.45% identity in 334 aa overlap); Q9RPT5|AMK SERINE/THREONINE PROTEIN KINASE HOMOLOG (SIMILAR TO THE SER/THR FAMILY OF PROTEIN KINASES) from Amycolatopsis mediterranei (606 aa), FASTA scores: opt: 537, E(): 1.5e-19, (35.55% identity in 346 aa overlap); Q9L0I0|PKAD PROTEIN SERINE/THREONINE KINASE from Streptomyces coelicolor (599 aa), FASTA scores: opt: 520, E(): 1e-18, (36.1% identity in 324 aa overlap); etc. N-terminal part also similar to O53510|PKNL_MYCTU|Rv2176|MT2232|MTV021.09 PROBABLE SERINE/THREONINE-PROTEIN KINASE from Mycobacterium tuberculosis strain H37Rv (399 aa), FASTA scores: opt: 511, E(): 2.1e-18, (35.15% identity in 313 aa overlap). Contains PS00107 Protein kinases ATP-binding region signature and PS00017 ATP/GTP-binding site motif A (P-loop). Contains Hank's kinase subdomain. FIRST PART OF THE PROTEIN SEEMS BELONG TO THE SER/THR FAMILY OF PROTEIN KINASES, AND SECOND PARTS SEEMS BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.890.; serine/threonine-protein kinase transcriptional regulatory protein	complement(3442656..3445988)	Mycobacterium tuberculosis H37Rv	888659
NP_217597.1	CDS	Rv3081	NC_000962.2	3446040	3447278	D	Rv3081, (MTV013.02), len: 412 aa. Conserved hypothetical protein. Second part of the protein (approximatively residues 250-412) shares weak similarity with other hypothetical proteins e.g. Q9YEU3|APE0488 from Aeropyrum pernix (188 aa), FASTA scores: opt: 149, E(): 0.019, E(): 0.019, (29.5% identity in 173 aa overlap); and first part shares weak similarity with C-terminal part of Q9RVT9|DR0933 ALPHA-AMLYASE from Deinococcus radiodurans (644 aa), FASTA scores: opt: 127, E(): 1.4, (27.25% identity in 198 aa overlap). Equivalent to AAK47502|MT3166 HYPOTHETICAL 48.3 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (436 aa) but shorter 24 aa in N-terminus. Contains PS00850 Glycine radical signature and possible helix-turn-helix motif at aa 53-74. TBparse score is 0.940.; hypothetical protein	3446040..3447278	Mycobacterium tuberculosis H37Rv	888650
NP_217598.1	CDS	virS	NC_000962.2	3447404	3448426	R	Rv3082c, (MT3167, MTV013.03c), len: 340 aa. virS, transcriptional regulatory protein araC/xylS family, probably involved in virulence (see citations below). Similar to many transcriptional regulators araC/xylS family e.g. Q9HZ25|PA3215 PROBABLE TRANSCRIPTIONAL REGULATOR (ARAC/XYLS FAMILY) from Pseudomonas aeruginosa (337 aa), FASTA scores: opt: 379, E(): 3e-17, (30.4% identity in 306 aa overlap); Q9Z3Y6|PHBR POLYHYDROXYBUTYRATE TRANSCRIPTIONAL ACTIVATOR from Pseudomonas sp. 61-3 (379 aa), FASTA scores: opt: 336, E(): 2e-14, (26.35% identity in 334 aa overlap); P72171|ORUR|PA0831 ORNITHINE UTILIZATION TRANSCRIPTIONAL REGULATOR oruR from Pseudomonas aeruginosa (339 aa), FASTA scores: opt: 274, E(): 1.9e-10, (23.7% identity in 321 aa overlap); Q9ZFW7 VIRULENCE REGULATING HOMOLOG from Pseudomonas alcaligenes (346 aa), FASTA scores: opt: 262, E(): 1.2e-09, (24.5% identity in 339 aa overlap); etc. Also similar to O69703|Rv3736|MTV025.084 PUTATIVE REGULATORY PROTEIN (ARAC/XYLS FAMILY) from Mycobacterium tuberculosis strain H37Rv (353 aa), FASTA scores: opt: 656, E(): 3.5e-35, (36.95% identity in 333 aa overlap). Has potential helix-turn-helix motif at positions 252-273. BELONGS TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.915.; virulence-regulating transcriptional regulator VirS	complement(3447404..3448426)	Mycobacterium tuberculosis H37Rv	888657
NP_217599.1	CDS	Rv3083	NC_000962.2	3448504	3449991	D	Rv3083, (MTV013.04), len: 495 aa. Probable monooxygenase (EC 1.-.-.-), highly similar to other putative monooxygenases flavin-binding family e.g. AAK48336|MT3969 from Mycobacterium tuberculosis strain CDC1551 (489 aa), FASTA scores: opt: 1692, E(): 4.9e-98, (49.7% identity in 489 aa overlap); Q9A588|CC2569 from Caulobacter crescentus (498 aa), FASTA scores: opt: 1684, E(): 1.6e-97, (52.25% identity in 484 aa overlap); Q9APW3 from Pseudomonas aeruginosa (508 aa), FASTA scores: opt: 1603, E(): 1.8e-92, (49.8% identity in 484 aa overlap); etc. TBparse score is 0.882.; monooxygenase	3448504..3449991	Mycobacterium tuberculosis H37Rv	888655
NP_217600.1	CDS	lipR	NC_000962.2	3449997	3450923	D	Rv3084, (MTV013.05), len: 308 aa. Probable lipR, N-Acetyl-hydrolase/esterase (EC 3.1.1.-), similar to other e.g. Q01109|BAH_STRH from Streptomyces hygroscopicus (299 aa), FASTA scores: opt: 558, E(): 4.1e-26, (40.25% identity in 246 aa overlap); Q9X8J4|SCE9.22 from Streptomyces coelicolor (266 aa), FASTA scores: opt: 544, E(): 2.5e-25, (36.95% identity in 257 aa overlap); Q56171|DEA from Streptomyces viridochromogenes (299 aa), FASTA scores: opt: 532, E(): 1.4e-24, (38.6% identity in 254 aa overlap); etc. Also similar to O06350|LIPF|Rv3487c|MTCY13E12.41c (277 aa), FASTA score: opt: 291, E(): 8.5e-10, (28.5% identity in 239 aa overlap). MAY BE BELONG TO THE 'GDXG' FAMILY OF LIPOLYTIC ENZYMES. TBparse score is 0.900.; acetyl-hydrolase/esterase LipR	3449997..3450923	Mycobacterium tuberculosis H37Rv	888652
NP_217601.1	CDS	Rv3085	NC_000962.2	3450920	3451750	D	Rv3085, (MTV013.06), len: 276 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various oxidoreductases in the short chain dehydrogenases/reductases family e.g. Q9CC98|ML1094 SHORT CHAIN ALCOHOL DEHYDROGENASE from Mycobacterium leprae (277 aa), FASTA scores: opt: 1059, E(): 4.8e-56, (61.65% identity in 266 aa overlap); Q9I3H6|PA1537 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginos (295 aa), FASTA scores: opt: 858, E(): 4.7e-44, (48.4% identity in 285 aa overlap); Q9CBP7|ML1740 POSSIBLE SHORT CHAIN REDUCTASE from Mycobacterium leprae (312 aa), FASTA scores: opt: 500, E(): 1e-22, (36.6% identity in 257 aa overlap); etc. Also similar to mycobacterium proteins O50460|Rv1245c|MTV006.17c DEHYDROGENASE SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY (276 aa), FASTA scores: opt: 1200, E(): 1.9e-64, (65.2% identity in 273 aa overlap); and P95101|Rv3057c|MTCY22D7.24 HYPOTHETICAL DEHYDROGENASE (287 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is 0.860.; short-chain type dehydrogenase/reductase	3450920..3451750	Mycobacterium tuberculosis H37Rv	888656
NP_217602.1	CDS	adhD	NC_000962.2	3451781	3452887	D	Rv3086, (MTV013.07), len: 368 aa. Probable adhD, zinc-type alcohol dehydrogenase (EC 1.1.1.-), highly similar to many e.g. O69045 HYPOTHETICAL ALCOHOL DEHYDROGENASE from Rhodococcus rhodochrous (370 aa), FASTA scores: opt: 1255, E(): 8.7e-68, (50.4% identity in 367 aa overlap); P25406|ADHB_UROHA ALCOHOL DEHYDROGENASE I-B from Uromastyx hardwickii (Indian spiny-tailed lizard) (375 aa), FASTA scores: opt: 787, E(): 8.2e-40, (35.9% identity in 373 aa overlap); P72324||ADHI_RHOSH ALCOHOL DEHYDROGENASE CLASS III from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (376 aa), FASTA scores: opt: 787, E(): 8.3e-40, (35.1% identity in 379 aa overlap). Also highly similar to P71818|Rv0761c|MTCY369.06c HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN from Mycobacterium tuberculosis strain H37Rv (375 aa), FASTA scores: opt: 1186, E(): 1.2e-63, (47.3% identity in 368 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE. TBparse score is 0.871. POSSIBLY REQUIRES ZINC FOR ITS ACTIVITY.; zinc-type alcohol dehydrogenase AdhD	3451781..3452887	Mycobacterium tuberculosis H37Rv	888654
NP_217603.1	CDS	Rv3087	NC_000962.2	3452925	3454343	D	Rv3087, (MTV013.08), len: 472 aa. Hypothetical protein, similar to several Mycobacterium tuberculosis proteins e.g. MTCY08D5.16, MTCY28.26, MTCY493.29c. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa). TBparse score is 0.880.; hypothetical protein	3452925..3454343	Mycobacterium tuberculosis H37Rv	888653
NP_217604.1	CDS	Rv3088	NC_000962.2	3454340	3455764	D	Rv3088, (MTV013.09), len: 474 aa. Hypothetical protein, similar to several Mycobacterium tuberculosis proteins e.g. MTCY31.23 (505 aa), MTCY13E12.34c (497 aa) and MTCY493.29c (459 aa). Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa). TBparse score is 0.897.; hypothetical protein	3454340..3455764	Mycobacterium tuberculosis H37Rv	888669
NP_217605.1	CDS	fadD13	NC_000962.2	3455761	3457272	D	Rv3089, (MTV013.10), len: 503 aa. Probable fadD13, Acyl-CoA Synthetase (EC 6.2.1.-), similar to many e.g. MTCI28.06, MTCY08D5.09, MTCY06G11.08 from Mycobacterium tuberculosis strain H37Rv; and to Q9F7P5 PREDICTED ACID--CoA LIGASE FADD13 from uncultured proteobacterium EBAC31A08 (504 aa), FASTA scores: opt: 1126, E(): 2.4e-62, (38.85% identity in 502 aa overlap); Q9EY88|FCS FERULOYL-CoA SYNTHETASE from Amycolatopsis sp. strain HR167 (491 aa), FASTA scores: opt: 1073, E(): 4.5e-59, (38.5% identity in 504 aa overlap); BAB49118|MLR1843 PROBABLE ACID-CoA LIGASE from Rhizobium loti (Mesorhizobium loti) (495 aa), FASTA scores: opt: 937, E(): 1.2e-50, (36.2% identity in 503 aa overlap); Q9KZC1|SC6F7.21 PROBABLE LONG-CHAIN-FATTY-ACID-CoA LIGASE from Streptomyces coelicolor (511 aa), FASTA scores: opt: 899, E(): 2.8e-48, (36.1% identity in 510 aa overlap); Q9A5P7|CC2400 PUTATIVE ACID-CoA LIGASE from Caulobacter crescentus (496 aa), FASTA scores: opt: 874, E(): 9.8e-47, (35.1% identity in 507 aa overlap); etc. Contains PS00455 Putative AMP-binding domain signature and PS00061 Short-chain alcohol dehydrogenase family signature. TBparse score is 0.877.; chain-fatty-acid-CoA ligase	3455761..3457272	Mycobacterium tuberculosis H37Rv	888666
NP_217606.1	CDS	Rv3090	NC_000962.2	3458211	3459098	D	Rv3090, (MTCY164.01), len: 295 aa. Hypothetical unknown Ala-, Val-rich protein. Hydrophobic stretch at N-terminus.; hypothetical protein	3458211..3459098	Mycobacterium tuberculosis H37Rv	888668
NP_217607.1	CDS	Rv3091	NC_000962.2	3459116	3460807	D	Rv3091, (MTCY164.02), len: 563 aa. Hypothetical protein, similar in part to O60859 NEUROPATHY TARGET ESTERASE from Homo sapiens (Human) (1327 aa), FASTA scores: opt: 177, E(): 0.0062, (30.65% identity in 173 aa overlap); and Q9I385|PA1640 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (345 aa), FASTA scores: opt: 152, E(): 0.069, (27.8% identity in 180 aa overlap).; hypothetical protein	3459116..3460807	Mycobacterium tuberculosis H37Rv	888665
NP_217608.1	CDS	Rv3092c	NC_000962.2	3460814	3461734	R	Rv3092c, (MTCY164.03c), len: 306 aa. Probable conserved integral membrane protein, highly similar to Q9RUT5|DR1297 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (311 aa), FASTA scores: opt: 941, E(): 9.8e-51, (55.65% identity in 309 aa overlap); Q9A8B8|CC1436 HYPOTHETICAL PROTEIN from Caulobacter crescentus (314 aa), FASTA scores: opt: 791, E(): 1.6e-41, (46.9% identity in 305 aa overlap); and also highly similar to Q9I2N8|PA1857 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (307 aa), FASTA scores: opt: 373, E(): 8.1e-16, (40.8% identity in 321 aa overlap); BAB36119|ECS2696 PUTATIVE METHYL-INDEPENDENT MISMATCH REPAIR PROTEIN from Escherichia coli strain O157:H7 (305 aa), FASTA scores: opt: 335, E(): 1.7e-13, (39.75% identity in 307 aa overlap).; integral membrane protein	complement(3460814..3461734)	Mycobacterium tuberculosis H37Rv	888667
NP_217609.1	CDS	Rv3093c	NC_000962.2	3461760	3462764	R	Rv3093c, (MTCY164.04c), len: 334 aa. Hypothetical oxidoreductase (EC 1.-.-.-), with some similarity with various oxidoreductases e.g. Q58929|MER|MJ1534 N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 300, E(): 1.1e-10, (24.1% identity in 324 aa overlap); and Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces violaceoruber (343 aa), FASTA scores: opt: 264, E(): 1.5e-08, (30.45% identity in 335 aa overlap); Q9CCV8|ML0348 POSSIBLE COENZYME F420-DEPENDENT OXIDOREDUCTASE from Mycobacterium leprae (350 aa), FASTA scores: opt: 220, E(): 6.4e-06, (26.5% identity in 328 aa overlap); etc.; oxidoreductase	complement(3461760..3462764)	Mycobacterium tuberculosis H37Rv	888663
NP_217610.1	CDS	Rv3094c	NC_000962.2	3462761	3463891	R	Rv3094c, (MTCY164.05c), len: 376 aa. Conserved hypothetical protein, some similarity with various proteins e.g. Q9RMR9|NRGC NRGC PROTEIN (corresponding gene seems regulated by NifA) from Bradyrhizobium japonicum (388 aa), FASTA scores: opt: 677, E(): 5.8e-35, (34.55% identity in 353 aa overlap); P26698|PIGM_RHOSO PIGMENT PROTEIN from Rhodococcus sp. strain ATCC 21145 (387 aa), FASTA scores: opt: 480, E(): 1.2e-22, (28.7% identity in 376 aa overlap); Q9F0J3|NCNH HYDROXYLASE from Streptomyces arenae (405 aa), FASTA scores: opt: 441, E(): 3.3e-20, (29.25% identity in 352 aa overlap); etc. Equivalent to AAK47516 from Mycobacterium tuberculosis strain CDC1551 (395 aa) but N-terminus shorter 19 aa.; hypothetical protein	complement(3462761..3463891)	Mycobacterium tuberculosis H37Rv	888661
NP_217611.1	CDS	Rv3095	NC_000962.2	3463973	3464449	D	Rv3095, (MTCY164.06), len: 158 aa. Possible regulatory protein, because contains possible helix-turn-helix motif at aa 39-61 (+4.83 SD). Similar to hypothetical proteins e.g. Q9I0C9|PA2713 from Pseudomonas aeruginosa (159 aa), FASTA scores: opt: 486, E(): 1.6e-25, (45.95% identity in 148 aa overlap); Q9AAF6|CC0645 from Caulobacter crescentus (188 aa), FASTA scores: opt: 479, E(): 5.3e-25, (45.75% identity in 153 aa overlap); Q9K408|2SCG61.07 from Streptomyces coelicolor (157 aa), FASTA scores: opt: 407, E(): 2.8e-20, (43.9% identity in 139 aa overlap); etc.; putative transcriptional regulatory protein	3463973..3464449	Mycobacterium tuberculosis H37Rv	888679
NP_217612.1	CDS	Rv3096	NC_000962.2	3464547	3465686	D	Rv3096, (MTCY164.07), len: 379 aa. Hypothetical protein, with slight similarity to several proteins e.g. Q09671|OYEB_SCHPO|SPAC5H10.10 PUTATIVE NADPH DEHYDROGENASE C5H10.10 (EC 1.6.99.1) (OLD YELLOW ENZYME HOMOLOG) from Schizosaccharomyces pombe (Fission yeast) (392 aa), FASTA scores: opt: 125, E(): 1.1, (25.45% identity in 165 aa overlap); and Q12603|XYNA_DICTH BETA-1,4-XYLANASE (EC 3.2.1.8) (ENDO-1,4-BETA-XYLANASE) from Dictyoglomus thermophilum (352 aa), FASTA scores: opt: 124, E(): 1.2, (25.65% identity in 195 aa overlap); etc. Contains glycosyl hydrolases family 5 signature (PS00659). TBparse score is 0.932.; hypothetical protein	3464547..3465686	Mycobacterium tuberculosis H37Rv	888678
YP_177924.1	CDS	lipY	NC_000962.2	3465778	3467091	R	triacylglycerol lipase	complement(3465778..3467091)	Mycobacterium tuberculosis H37Rv	888677
NP_217614.1	CDS	Rv3098c	NC_000962.2	3467210	3467662	R	Rv3098c, (MTCY164.09c), len: 150 aa. Hypothetical unknown protein (shorter version of MTCY164.09c).; hypothetical protein	complement(3467210..3467662)	Mycobacterium tuberculosis H37Rv	888676
NP_217615.1	CDS	Rv3099c	NC_000962.2	3468413	3469264	R	Rv3099c, (MTCY164.10c), len: 283 aa. Conserved hypothetical protein, some similarity with hypothetical proteins e.g. Q9XA69|SCGD3.09 from Streptomyces coelicolor (274 aa), FASTA scores: opt: 384, E(): 1.8e-17, (32.7% identity in 269 aa overlap); and P71606|Y036_MYCTU|Rv0036c from Mycobacterium tuberculosis strain H37Rv (257 aa), FASTA scores: opt: 179, E(): 0.00024, (25.85% identity in 205 aa overlap).; hypothetical protein	complement(3468413..3469264)	Mycobacterium tuberculosis H37Rv	888674
NP_217616.1	CDS	smpB	NC_000962.2	3469301	3469783	R	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein	complement(3469301..3469783)	Mycobacterium tuberculosis H37Rv	888675
NP_217617.1	CDS	ftsX	NC_000962.2	3469786	3470679	R	Rv3101c, (MTCY164.12c), len: 297 aa. Putative ftsX, cell division protein, septation component transport integral membrane protein ABC transporter (see citations below), equivalent to O32882|FTSX_MYCLE|ML0670|MLCB1779.20c CELL DIVISION PROTEIN from Mycobacterium leprae (297 aa), FASTA scores: opt: 1597, E(): 9.2e-93, (80.8% identity in 297 aa overlap); and similar to others e.g. Q9L1S7|SCE59.27c from Streptomyces coelicolor (305 aa), FASTA scores: opt: 585, E(): 1.9e-29, (34.55% identity in 304 aa overlap); O34876|FTSX_BACSU from Bacillus subtilis (296 aa), FASTA scores: opt: 318, E(): 9.1e-13, (24.65% identity in 300 aa overlap); Q9K6X3|FTSX|BH3601 from Bacillus halodurans (298 aa), FASTA scores: opt: 290, E(): 5.2e-11, (22.75% identity in 299 aa overlap); etc. BELONGS TO THE FTSX FAMILY.; putative cell division protein FTSX (septation component-transport integral membrane protein ABC transporter)	complement(3469786..3470679)	Mycobacterium tuberculosis H37Rv	888673
NP_217618.1	CDS	ftsE	NC_000962.2	3470680	3471369	R	Rv3102c, (MTCY164.13_2c), len: 229 aa. Putative ftsE, cell division protein, septation component transport ATP-binding protein ABC transporter (see citations below), equivalent to O32883|FTSE|ML0669 CELL DIVISION ATP-BINDING PROTEIN from Mycobacterium leprae (229 aa), FASTA scores: opt: 1384, E(): 2.4e-74, (91.7% identity in 229 aa overlap); and similar to Q9L1S6|FTSE from Streptomyces coelicolor (229 aa), FASTA scores: opt: 914, E(): 8.7e-47, (62.85% identity in 226 aa overlap); Q9A0S4|FTSE|SPY0644 from Streptococcus pyogenes (230 aa), FASTA scores: opt: 866, E(): 5.7e-44, (57.9% identity in 228 aa overlap); Q9CGX0|FTSE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (230 aa), FASTA scores: opt: 792, E(): 1.3e-39, (52.2% identity in 228 aa overlap); etc. Other relatives from Mycobacterium tuberculosis include: MTCY253.24; MTCY16B7.10; MTCY9C4.04c; MTCY50.01; MTCY05A6.09c; MTCY04C12.31. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and ABC transporters family signature (PS00211). BELONG TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; putative cell division ATP-binding protein FTSE (septation component-transport ATP-binding protein ABC transporter)	complement(3470680..3471369)	Mycobacterium tuberculosis H37Rv	888672
NP_217619.1	CDS	Rv3103c	NC_000962.2	3471413	3471850	R	Rv3103c, (MTCY164.13c), len: 145 aa. Hypothetical unknown pro-rich protein, with some similarity to Proline-rich proteins e.g. Q39789 PROLINE-RICH CELL WALL PROTEIN from Gossypium hirsutum (Upland cotton) (214 aa), FASTA scores: opt: 267, E(): 0.00014, (40% identity in 110 aa overlap). Equivalent to AAK47525 from M. mycobacterium strain CDC1551 (158 aa) but shorter 13 aa.; hypothetical protein	complement(3471413..3471850)	Mycobacterium tuberculosis H37Rv	888798
NP_217620.1	CDS	Rv3104c	NC_000962.2	3471852	3472778	R	Rv3104c, (MTCY164.14c), len: 308 aa. Possible conserved transmembrane protein, with some similarity to hypthetical proteins e.g. Q9L1X9|SC8E4A.26 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (408 aa), FASTA scores: opt: 514, E(): 4.3e-25, (35.2% identity in 287 aa overlap); Q9XA89|CF43A.26c HYPOTHETICAL 36.1 KDA PROTEIN from Streptomyces coelicolor (333 aa), FASTA scores: opt: 482, E(): 3.7e-23, (34.9% identity in 301 aa overlap); Q55987|SLR0765 HYPOTHETICAL 68.9 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (617 aa), FASTA scores: opt: 429, E(): 1.3e-19, (30.6% identity in 278 aa overlap); etc.; transmembrane protein	complement(3471852..3472778)	Mycobacterium tuberculosis H37Rv	888685
NP_217621.1	CDS	prfB	NC_000962.2	3472768	3473904	R	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2	complement(3472768..3473904)	Mycobacterium tuberculosis H37Rv	888820
NP_217622.1	CDS	fprA	NC_000962.2	3474007	3475377	D	Rv3106, (MTCY164.16), len: 456 aa. fprA, NADPH:adrenodoxin oxidoreductase (NADPH-ferredoxin reductase) (EC 1.18.1.2) (see citations below), equivalent to O32886|MLCB1779.25|FPRA|ML0666 from Mycobacterium leprae (456 aa), FASTA scores: opt: 2505, E(): 1.2e-142, (81,05% identity in 459 aa overlap); also similar to other NADPH:adrenodoxin oxidoreductases e.g. Q9RX19|DR0496 from Deinococcus radiodurans (479 aa), FASTA scores: opt: 1331, E(): 2.6e-72, (48.9% identity in 454 aa overlap); Q9RK35|SCF15.02 from Streptomyces coelicolor (454 aa), FASTA scores: opt: 1102, E(): 1.3e-58, (41.35% identity in 462 aa overlap); P82861 from Salvelinus fontinalis (Brook trout) (498 aa), FASTA scores: opt: 827, E(): 4e-42, (41.3% identity in 460 aa overlap); Q9V3T9|ADRO_DROME from Drosophila melanogaster (Fruit fly) (466 aa), FASTA scores: opt: 790, E(): 6.3e-40, (39.45% identity in 459 aa overlap); etc. Also similar to Q10547|FPRB|Rv0886|MT0909|MTCY31.14 from Mycobacterium tuberculosis strain H37Rv (575 aa), FASTA scores: opt: 894, E(): 4.4e-46, (42.05% identity in 459 aa overlap).; NADPH:adrenodoxin oxidoreductase FPRA (NADPH-ferredoxin reductase)	3474007..3475377	Mycobacterium tuberculosis H37Rv	888839
NP_217623.1	CDS	agpS	NC_000962.2	3475378	3476961	R	Rv3107c, (MTCY164.17c), len: 527 aa. Possible agpS, alkyl-dihydroxyacetonephosphate synthase (EC 2.5.1.26), similar to others and some various enzymes e.g. AAK46595|MT2311 PUTATIVE ALKYL-DIHYDROXYACETONEPHOSPHATE SYNTHASE from Mycobacterium tuberculosis strain CDC1551 (529 aa), FASTA scores: opt: 1052, E(): 2.1e-58, (37.1% identity in 542 aa overlap); Q9RJ97|SCF91.28c PUTATIVE FLAVOPROTEIN from Streptomyces coelicolor (530 aa), FASTA scores: opt: 972, E(): 2.2e-53, (36.2% identity in 544 aa overlap); O96759|ADAS_DICDI ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE (EC 2.5.1.26) from Dictyostelium discoideum (Slime mold) (611 aa), FASTA scores: opt: 617, E(): 4.5e-31, (33.95% identity in 480 aa overlap); O97157|ADAS_TRYBB ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE from Trypanosoma brucei (613 aa), FASTA scores: opt: 567, E(): 6.2e-28, (29.15% identity in 521 aa overlap); etc. Also similar to O53525|Rv2251|MTV022.01 HYPOTHETICAL 49.8 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (475 aa), FASTA scores: opt: 1019, E(): 2.3e-56, (38.6% identity in 487 aa overlap). BELONGS TO THE FAD-BINDING OXIDOREDUCTASE/TRANSFERASE FAMILY 4. COFACTOR: FAD (BY SIMILARITY).; alkyldihydroxyacetonephosphate synthase AgpS	complement(3475378..3476961)	Mycobacterium tuberculosis H37Rv	887657
NP_217624.1	CDS	Rv3108	NC_000962.2	3477060	3477500	D	Rv3108, (MTCY164.18), len: 146 aa. Hypothetical unknown protein.; hypothetical protein	3477060..3477500	Mycobacterium tuberculosis H37Rv	888686
YP_177925.1	CDS	moaA1	NC_000962.2	3477649	3478728	D	Rv3109, (MTCY164.19), len: 359 aa. Probable moaA1, molybdenum cofactor biosynthesis protein, highly similar to others e.g. P39757|MOAA_BACSU|NARA|NARAB from Bacillus subtilis (341 aa), FASTA scores: opt: 810, E(): 6.2e-44, (39.75% identity in 327 aa overlap); O67929|MOAA_AQUAE|AQ_2183 from Aquifex aeolicus (320 aa), FASTA scores: opt: 794, E(): 6e-43, (40.55% identity in 323 aa overlap); Q9ZIM6|MOAA_STACA from Staphylococcus carnosus (340 aa), FASTA scores: opt: 783, E(): 3.2e-42, (38.65% identity in 326 aa overlap); etc. Also highly similar to O53143|MOAA3|MOA3_MYCTU|MT3427 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A 3 from Mycobacterium tuberculosis strain F4 (378 aa), FASTA scores: opt: 1762, E(): 4.7e-104, (74.3% identity in 350 aa overlap); and similar to O53881|MOA2_MYCTU|MOAA2|Rv0869c|MT0892|MTV043.62 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A 2 from Mycobacterium tuberculosis strain H37Rv (360 aa), FASTA scores: opt: 657, E(): 3e-34, (36.55% identity in 309 aa overlap). BELONGS TO THE MOAA / NIFB / PQQE FAMILY. Note that previously known as moaA.; moaA; molybdenum cofactor biosynthesis protein A	3477649..3478728	Mycobacterium tuberculosis H37Rv	888836
YP_177926.1	CDS	moaB1	NC_000962.2	3478779	3479174	D	Rv3110, (MTCY164.20), len: 131 aa. Probable moaB1, pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96), similar to others e.g. P73790|SSL2296 from Synechocystis sp. strain PCC 6803 (96 aa), FASTA scores: opt: 195, E(): 6.2e-07, (35.4% identity in 96 aa overlap); Q9PAB4|PHS_XYLFA|XF2604 from Xylella fastidiosa (116 aa), FASTA scores: opt: 187, E(): 2.6e-06, (36.25% identity in 102 aa overlap); AAK42360|Q97WM6|PHS_SULSO|SSO2187 from Sulfolobus solfataricus (114 aa), FASTA scores: opt: 177, E(): 1.3e-05, (34.6% identity in 78 aa overlap); etc. Also highly similar to AAK47768|MT3426 PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis CDC1551 (124 aa), FASTA scores: opt: 383, E(): 7.7e-20, (50.0% identity in 110 aa overlap). BELONGS TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. Note that previously known as moaB.; moaB; pterin-4-alpha-carbinolamine dehydratase MoaB1	3478779..3479174	Mycobacterium tuberculosis H37Rv	888683
YP_177927.1	CDS	moaC	NC_000962.2	3479171	3479683	D	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC	3479171..3479683	Mycobacterium tuberculosis H37Rv	888680
YP_177928.1	CDS	moaD1	NC_000962.2	3479700	3479951	D	Rv3112, (MTCY164.22), len: 83 aa. Probable moaD1, molybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1)), similar to others e.g. Q9HJF0|TA1019 from Thermoplasma acidophilum (85 aa), FASTA scores: opt: 144, E(): 0.0012, (31.7% identity in 82 aa overlap); BAB59710|TVG0556526 from Thermoplasma volcanium (90 aa), FASTA scores: opt: 144, E(): 0.0012, (31.7% identity in 82 aa overlap); P30748|MOAD_ECOLI|CHLA4|CHLM|B0784 from Escherichia coli strain K12 (81 aa), FASTA scores: opt: 116, E(): 0.11, (36.9% identity in 84 aa overlap); etc. N-terminus also highly similar to to O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 333, E(): 2e-16, (65.05% identity in 83 aa overlap); and some similarity with Rv0868c|MTV043.61c|MOAD2 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D 2 (92 aa). Note that previously known as moaD.; moaD; molybdenum cofactor biosynthesis protein D	3479700..3479951	Mycobacterium tuberculosis H37Rv	888897
NP_217629.1	CDS	Rv3113	NC_000962.2	3480074	3480742	D	Rv3113, (MTCY164.23), len: 222 aa. Possible phosphatase (EC 3.1.3.-), with weak similarity to other phosphatases e.g. Q9KYY0|SCE33.02c from Streptomyces coelicolor (223 aa), FASTA scores: opt: 368, E(): 1.2e-16, (32.9% identity in 222 aa overlap); and Q55039|GPH_SYNP7|CBBZ PHOSPHOGLYCOLATE PHOSPHATASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (212 aa), FASTA scores: opt: 176, E(): 0.00025, (24.7% identity in 182 aa overlap).; phosphatase	3480074..3480742	Mycobacterium tuberculosis H37Rv	888781
NP_217630.1	CDS	Rv3114	NC_000962.2	3480759	3481289	D	Rv3114, (MTCY164.24), len: 176 aa. Conserved hypothetical protein, with some similarity to Q9F9W7 CYTOSINE DEAMINASE from Bifidobacterium longum (143 aa), FASTA scores: opt: 207, E(): 2.2e-07, (37.05% identity in 108 aa overlap); and Q9RV23|DR1207 CELL CYCLE PROTEIN MESJ, PUTATIVE/CYTOSINE DEAMINASE-RELATED PROTEIN from Deinococcus radiodurans (600 aa), FASTA scores: opt: 212, E(): 3.5e-07, (33.35% identity in 177 aa overlap). Equivalent to AAK47536|MT3196 CYTIDINE AND DEOXYCYTIDYLATE DEAMINASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (187 aa) but shorter 11 aa.; hypothetical protein	3480759..3481289	Mycobacterium tuberculosis H37Rv	888779
NP_217631.1	CDS	Rv3115	NC_000962.2	3481451	3482698	D	Rv3115, (MTCY164.25), len: 415 aa. Probable IS1081 transposase, similar to others. Has transposases, mutator family, signature (PS01007). Other copies are MTCY10G2.02c, MTCY441.35, MTCY77.03c. TBparse score is 0.894.; transposase	3481451..3482698	Mycobacterium tuberculosis H37Rv	888790
YP_177929.1	CDS	moeB2	NC_000962.2	3482776	3483945	D	Rv3116, (MTCY164.26), len: 389 aa. Probable moeB2, molybdopterin cofactor biosynthesis protein, equivalent to Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395 aa), FASTA scores: opt: 1433, E(): 8e-80, (57.8% identity in 384 aa overlap). Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA scores: opt: 1562, E(): 1.1e-87, (58.15% identity in 380 aa overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas perfectomarina) (391 aa), FASTA scores: opt: 1311, E(): 2.1e-72, (52.4% identity in 395 aa overlap); O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA scores: opt: 1238, E(): 5.7e-68, (51.4% identity in 393 aa overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1212, E(): 2.2e-66, (46.5% identity in 398 aa overlap); etc. Also highly similar to O05860|MTCY07D11.20|MOEB1|Rv3206c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis strain H37Rv (392 aa), FASTA scores: opt: 1445, E(): 1.5e-80, (56.25% identity in 400 aa overlap). BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that previously known as moeB.; moeB; molybdenum cofactor biosynthesis protein MoeB	3482776..3483945	Mycobacterium tuberculosis H37Rv	888808
NP_217633.1	CDS	cysA3	NC_000962.2	3483974	3484807	D	Rv3117, (MTCY164.27, MT3199, O05793), len: 277 aa. Probable cysA3 (alternate gene name: sseC3), thiosulfate sulfurtransferase (EC 2.8.1.1) (see Wooff et al., 2002), equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE PUTATIVE SULFURTRANSFERASE THIOSULFATE from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa), FASTA scores: opt: 1442, E(): 1.7e-84, (75.55% identity in 274 aa overlap); Q9RXT9DR0217|DR0217 from Deinococcus radiodurans (286 aa), FASTA scores: opt: 1046, E(): 2.6e-59, (53.8% identity in 275 aa overlap); Q9HMT7|TSSA|VNG2393G from Halobacterium sp. strain NRC-1 (293 aa), FASTA scores: opt: 1030, E(): 2.7e-58, (56.1% identity in 278 aa overlap); Q9Y8N8|APE2595 from Aeropyrum pernix (218 aa), FASTA scores: opt: 808, E(): 2.7e-44, (53.5% identity in 215 aa overlap); etc. Identical second copy present as Rv0815c|AL022004|MTV043.07c|MT0837|O05793|cysA2 (277 aa) (100.0% identity in 277 aa overlap). Also shows some similarity to P96888|THT2_MYCTU|SSEA|Rv3283|MT3382|MTCY71.23 PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium tuberculosis (297 aa), FASTA scores: opt: 955, E(): 1.6e-53, (50.2% identity in 271 aa overlap); and Q59570|THT3_MYCTU|SSEB|Rv2291|MT2348|MTCY339.19c PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium tuberculosis (284 aa), FASTA scores: E(): 1.4e-14, (26.7% identity in 292 aa overlap). Contains rhodanese active site and C-terminal signatures (PS00380, PS00683). BELONGS TO THE RHODANESE FAMILY. TBparse score is 0.901.; sseC3; thiosulfate sulfurtransferase CysA3	3483974..3484807	Mycobacterium tuberculosis H37Rv	888802
YP_177930.1	CDS	sseC1	NC_000962.2	3484809	3485111	D	Rv3118, (MTCY164.28, O05794), len: 100 aa. sseC1, conserved hypothetical protein, equivalent to Q9CBC7|ML2199 HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa), FASTA scores: opt: 545, E(): 3.1e-30, (84.0% identity in 10 aa overlap). Also similar to hypothetical proteins e.g. Q50035 from Saccharopolyspora erythraea (Streptomyces erythraeus) (101 aa), FASTA scores: opt: 345, E(): 9.7e-17, (57.15% identity in 98 aa overlap); and Q9K4H3|SCD66.02 from Streptomyces coelicolor (95 aa), FASTA scores: opt: 249, E(): 2.8e-10, (48.5% identity in 99 aa overlap). Some weak similarity with Q9ZB84|PCAG PROTOCATECHUATE 3,4-DIOXYGENASE ALPHA-SUBUNIT from Pseudomonas marginata (196 aa), FASTA scores: opt: 109, E(): 1.4, (31.3% identity in 83 aa overlap); and other bacterial proteins. Identical second copy present as Rv0814c|AL022004|MTV043.06c|SSEC2 from Mycobacterium tuberculosis (100 aa) (100.0% identity in 100 aa overlap). Note that previously known as sseC.; sseC; hypothetical protein	3484809..3485111	Mycobacterium tuberculosis H37Rv	888809
YP_177931.1	CDS	moaE1	NC_000962.2	3485132	3485575	D	Rv3119, (MTCY164.29), len: 147 aa. Probable moaE1, molybdopterin converting factor E (molybdopterin converting factor (subunit 2)), highly similar to others e.g. O31705|MOAE from Bacillus subtilis (157 aa), FASTA scores: opt: 390, E(): 8.6e-19, (43.95% identity in 132 aa overlap); Q9K8I7|MOAE|BH3019 from Bacillus halodurans (156 aa), FASTA scores: opt: 369, E(): 2e-17, (42.4% identity in 132 aa overlap); P30749|MOAE_ECOLI|CHLA5|B0785 from Escherichia coli strain K12 (149 aa), FASTA scores: opt: 312, E(): 1.1e-13, (38.45% identity in 130 aa overlap); etc. Also highly similar (but shorter 74 aa) to O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 733, E(): 3.9e-41, (76.2% identity in 143 aa overlap); and highly similar to O53878|MOAE2|Rv0866|MTV043.59 PUTATIVE MOLYBDOPTERIN SYNTHASE LARGE SUBUNIT from Mycobacterium tuberculosis (141 aa), FASTA scores: opt: 321, E(): 2.6e-14, (40.9% identity in 132 aa overlap). Note that previously known as moaE.; moaE; molybdenum cofactor biosynthesis protein E	3485132..3485575	Mycobacterium tuberculosis H37Rv	888811
NP_217636.1	CDS	Rv3120	NC_000962.2	3485572	3486174	D	Rv3120, (MTCY164.30), len: 200 aa. Conserved hypothetical protein, with weak similarity to several hypothetical proteins and many N-methyl transferases e.g. Q9X9V1|ORF8 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor A3(2) (208 aa), FASTA scores: opt: 177, E(): 0.00011, (34.6% identity in 130 aa overlap); Q9XA90|SCF43A.25c PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (215 aa), FASTA scores: opt: 147, E(): 0.011, (31.3% identity in 166 aa overlap); BAB52127|MLL5735 PROBABLE METHYLTRANSFERASE from Rhizobium loti (Mesorhizobium loti) (247 aa), FASTA scores: opt: 133, E(): 0.11, (29.75% identity in 158 aa overlap). Highly similar to O53374|Rv3322c|MTV016.22c POSSIBLE METHYLTRANSFERASE from Mycobacterium tuberculosis strain H37Rv (204 aa), FASTA scores: opt: 691, E(): 1.1e-38, (57.0% identity in 200 aa overlap).; hypothetical protein	3485572..3486174	Mycobacterium tuberculosis H37Rv	888828
NP_217637.1	CDS	cyp141	NC_000962.2	3486509	3487711	D	Rv3121, (MTCY164.31), len: 400 aa. Probable cyp141, cytochrome P-450 integral membrane protein (EC 1.14.-.-), similar to other cytochrome P450-dependent oxidases e.g. Q9X5P9|CYP107N1 from Streptomyces lavendulae (410 aa), FASTA scores: opt: 825, E(): 3.1e-42, (33.35% identity in 393 aa overlap); Q59819|OLEP|CYP107D1 from Streptomyces antibioticus (407 aa), FASTA scores: opt: 812, E(): 1.9e-41, (34.85% identity in 396 aa overlap); O32460|CYP107M1 from Actinomadura hibisca (411 aa), FASTA scores: opt: 713, E(): 1.6e-35, (31.05% identity in 396 aa overlap); P55544|CPXP_RHISN|CYP112A|Y4LD from Rhizobium sp. strain NGR234 (400 aa), FASTA scores: opt: 688, E(): 5.1e-34, (33.0% identity in 406 aa overlap); etc. Also similar to MTCY339.44c, MTCY369.22, MTCY50.26, MTCY03C7.11, MTCY339.34c, MTCY339.42, MTCY369.11c. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY.; cytochrome P450 141	3486509..3487711	Mycobacterium tuberculosis H37Rv	887409
NP_217638.1	CDS	Rv3122	NC_000962.2	3488089	3488559	D	Rv3122, (MTCY164.32), len: 156 aa. Hypothetical unknown protein.; hypothetical protein	3488089..3488559	Mycobacterium tuberculosis H37Rv	888890
NP_217639.1	CDS	Rv3123	NC_000962.2	3488569	3489063	D	Rv3123, (MTCY164.33), len: 162 aa. Hypothetical unknown protein, but N-terminus shares weak similarity with N-terminal part of O93439|CMESO-1 BHLH TRANSCRIPTION FACTOR from Gallus gallus (Chicken) (287 aa), FASTA scores: opt: 129, E(): 0.81, (38.75% identity in 80 aa overlap).; hypothetical protein	3488569..3489063	Mycobacterium tuberculosis H37Rv	888823
NP_217640.1	CDS	Rv3124	NC_000962.2	3489506	3490375	D	Rv3124, (MTCY164.34), len: 289 aa. Probable transcriptional regulatory protein, similar to many Streptomyces and Mycobacterium tuberculosis regulatory proteins e.g. Q11052|YC67_MYCTU|Rv1267c|MT1305|MTCY50.15 from Mycobacterium tuberculosis strain H37Rv (388 aa), FASTA scores: opt: 963, E(): 2e-56, (55.15% identity in 252 aa overlap); O53145 from Mycobacterium tuberculosis (381 aa); P71484|EMBR from Mycobacterium avium (384 aa), FASTA scores: opt: 859, E(): 1.5e-49, (52.2% identity in 249 aa overlap); Q9XCC3|TYLT from Streptomyces fradiae (404 aa), FASTA scores: opt: 462, E(): 3.1e-23, (35.05% identity in 254 aa overlap); Q9XCC4|TYLS from Streptomyces fradiae (277 aa), FASTA scores: opt: 456, E(): 5.6e-23, (33.45% identity in 269 aa overlap); etc. Start chosen by similarity, alternative possible (see AAK47548 from Mycobacterium tuberculosis strain CDC1551, longer N-terminus (311 aa)).; transcriptional regulatory protein	3489506..3490375	Mycobacterium tuberculosis H37Rv	888825
YP_177932.1	CDS	PPE49	NC_000962.2	3490476	3491651	R	Rv3125c, (MTCY164.35c), len: 391 aa. Member of the Mycobacterium tuberculosis PPE family, similar to other e.g. P95247|Rv2352c|MTCY98.21c (391 aa), FASTA scores: opt: 1576, E(): 3.8e-72, (62.55% identity in 398 aa overlap), MTCY98.0029c, MTCY03A2.22c, MTCY10G2.10, MTCY02B10.25c, MTCI364.08, M TCY21C12.09c, MTCY48.17.; PPE family protein	complement(3490476..3491651)	Mycobacterium tuberculosis H37Rv	888892
NP_217642.1	CDS	Rv3126c	NC_000962.2	3491808	3492122	R	Rv3126c, (MTCY164.36c), unknown, len: 104 aa. Hypothetical unknown protein. Shortened version of MTCY164.36c, avoiding overlap.; hypothetical protein	complement(3491808..3492122)	Mycobacterium tuberculosis H37Rv	888806
NP_217643.1	CDS	Rv3127	NC_000962.2	3492147	3493181	D	Rv3127, (MTCY164.37), len: 344 aa. Hypothetical protein, highly similar to Mycobacterium tuberculosis protein O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 1212, E(): 6e-69, (56.7% identity in 321 aa overlap), and also similar to P95195|MTCY03A2.27c (332 aa), FASTA scores: opt: 521, E(): 1.6e-25; (35.0% identity in 326 aa overlap). Some similarity to C-terminal half of hypothetical Mycobacterium tuberculosis proteins.; hypothetical protein	3492147..3493181	Mycobacterium tuberculosis H37Rv	888850
YP_177933.1	CDS	Rv3129	NC_000962.2	3494660	3494992	D	Rv3129, (MTCY164.40), len: 110 aa. Conserved hypothetical protein, with some similarity to various hypothetical proteins from Streptomyces coelicolor e.g. Q9RI34|SCJ12.26 HYPOTHETICAL 14.5 KDA PROTEIN (137 aa), FASTA scores: opt: 141, E(): 0.0016, (39.3% identity in 84 aa overlap); Q9RI49|SCJ12.09c HYPOTHETICAL 15.8 KDA PROTEIN (146 aa), FASTA scores: opt: 141, E(): 0.0017, (38.05% identity in 92 aa overlap); Q9RJ05|SCJ1.09C POSSIBLE DNA-BINDING PROTEIN (233 aa), FASTA scores: opt: 140, E(): 0.0029, (34.85% identity in 89 aa overlap); Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1 BETA SUBUNIT (334 aa); etc.; hypothetical protein	3494660..3494992	Mycobacterium tuberculosis H37Rv	888901
NP_217646.1	CDS	tgs1	NC_000962.2	3494975	3496366	R	triacylglycerol synthase	complement(3494975..3496366)	Mycobacterium tuberculosis H37Rv	888841
NP_217647.1	CDS	Rv3131	NC_000962.2	3496551	3497549	D	Rv3131, (MTCY03A2.27c), len: 332 aa. Hypothetical protein, similar to other hypothetical bacterial proteins e.g. O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 568, E(): 2.5e-27, (36.7% identity in 321 aa overlap); O05800|Rv3127|MTCY164.37 (344 aa), FASTA scores: opt: 521, E(): 1.9e-24, (34.95% identity in 326 aa overlap); Q9RI33|SCJ12.27c from Streptomyces coelicolor (335 aa), FASTA scores: opt: 441, E(): 1.3e-19, (35.75% identity in 319 aa overlap); Q9RI44|SCJ12.14 from Streptomyces coelicolor (309 aa), FASTA scores: opt: 328, E(): 9.3e-13, (27.9% identity in 308 aa overlap); Q9CBP5|ML1751 from Mycobacterium leprae (721 aa), FASTA scores: opt: 137, E(): 0.78, (26.15% identity in 298 aa overlap); etc. Equivalent to AAK47555 from Mycobacterium tuberculosis strain CDC1551 but shorter 12 aa.; hypothetical protein	3496551..3497549	Mycobacterium tuberculosis H37Rv	888838
NP_217648.1	CDS	devS	NC_000962.2	3497529	3499265	R	Rv3132c, (MTCY03A2.26), len: 578 aa. devS, membrane-bound two component sensor histidine kinase (EC 2.7.3.-) (see citations below; dev for Differentially Expressed in Virulent strain), similar to others two component sensors e.g. Q9RI43|SCJ12.15c PUTATIVE TWO-COMPONENT SENSOR from Streptomyces coelicolor (585 aa), FASTA scores: opt: 1305, E(): 2.5e-69, (41.35% identity in 573 aa overlap); Q9ZBY4|SCD78.15 PUTATIVE TWO COMPONENT SENSOR from Streptomyces coelicolor (560 aa), FASTA scores: opt: 1194, E(): 8.1e-63, (41.05% identity in 558 aa overlap); O85371|CPRS TWO COMPONENT REGULATOR from Rhodococcus sp (563 aa), FASTA scores: opt: 803, E(): 8.3e-40, (38.4% identity in 552 aa overlap); Q9L094|SCC24.23 PUTATIVE TWO-COMPONENT SENSOR HISTIDINE KINASE from Streptomyces coelicolor (similarity only in C-terminus for this one); etc. Also highly similar to mycobacterium O53473|Rv2027c|MTV018.14c PUTATIVE MEMBRANE PROTEIN (573 aa), FASTA scores: opt: 2333, E(): 7.6e-130, (61.45% identity in 576 aa overlap). TBparse score is 0.921.; two component sensor histidine kinase DEVS	complement(3497529..3499265)	Mycobacterium tuberculosis H37Rv	888829
NP_217649.1	CDS	devR	NC_000962.2	3499262	3499915	R	Rv3133c, (MTCY03A2.25), len: 217 aa. devR, two component transcriptional regulator (see Dasgupta et al., 2000; dev for Differentially Expressed in Virulent strain), highly similar to several e.g. O85372|CPRR TWO COMPONENT REGULATOR from Rhodococcus sp. (212 aa), FASTA scores: opt: 868, E(): 6.2e-46, (65.05% identity in 206 aa overlap); Q9RI42|SCJ12.16c PUTATIVE LUXR FAMILY TWO-COMPONENT RESPONSE REGULATOR from Streptomyces coelicolor (233 aa), FASTA scores: opt: 849, E(): 9.7e-45, (60.55% identity in 218 aa overlap); Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (218 aa), FASTA scores: opt: 835, E(): 6.5e-44, (61.55% identity in 208 aa overlap); and similar to others. Contains bacterial regulatory proteins, LuxR family signature (PS00622) near C-terminus as seen in bvgA, comA, dctR, degU, evgA, fimZ, fixJ, gacA, glpR, narL, narP, nodW, rcsB and uhpA. Helix-turn-helix motif at 166-187 (+3.15 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS.; two component transcriptional regulatory protein DevR	complement(3499262..3499915)	Mycobacterium tuberculosis H37Rv	888842
NP_217650.1	CDS	Rv3134c	NC_000962.2	3499943	3500749	R	Rv3134c, (MTCY03A2.240, len: 268 aa. Ala-, Val- rich protein (see citations below), related to other hypothetical Mycobacterium tuberculosis proteins e.g. O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt: 562, E(): 3.2e-28, (40.65% identity in 273 aa overlap); O06188|Rv2624c|MTCY01A10.08 (272 aa), FASTA scores: opt: 458, E(): 1.1e-21, (36.55% identity in 271 aa overlap); O53472|R2026c|MTV018.13c (294 aa), FASTA scores: opt: 232, E(): 1.9e-07, (30.45% identity in 276 aa overlap); etc. Shares some similarity with other hypothetical proteins from Streptomyces coelicolor e.g. Q9RIZ8|SCJ1.16c (294 aa), FASTA scores: opt: 207, E(): 6.9e-06, (28.9% identity in 263 aa overlap); Q9K4L5|SC5F8.09 PUTATIVE STRESS-INDUCIBLE PROTEIN (312 aa), FASTA scores: opt: 204, E(): 1.1e-05, (28.4% identity in 271 aa overlap); etc. Equivalent to AAK47558|MT3220 Universal stress protein family from Mycobacterium tuberculosis strain CDC1551 (268 aa). Rv3134c seems cotranscribed with devR-devS (see Sherman et al., 2001).; hypothetical protein	complement(3499943..3500749)	Mycobacterium tuberculosis H37Rv	887558
YP_177934.1	CDS	PPE50	NC_000962.2	3501334	3501732	D	Rv3135, (MTCY03A2.23c), len: 132 aa. Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family, similar to P95190|Rv3136|MTCY03A2.22c (380 aa), FASTA scores: opt: 494, E(): 6.7e-25, (57.25% identity in 131 aa overlap) (next ORF downstream), MTY21C12_9, MTCY3C7_24, MTCI125_27, MTV049_12, MTV049_9, MTV049_11 , MTCY274_24 etc. TBparse score is 0.912.; PPE family protein	3501334..3501732	Mycobacterium tuberculosis H37Rv	888153
YP_177935.1	CDS	PPE51	NC_000962.2	3501794	3502936	D	Rv3136, (MTCY03A2.22c), len: 380 aa. Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family, similar to Q9AGF0|Ov2770c Rv2770c-LIKE PROTEIN from M. microti (397 aa), FASTA scores: opt: 917, E(): 9e-41, (46.15% identity in 388 aa overlap); O33312|Rv2770c|MTV002.35c, MTV002_36, MTCI125_26, MTCY10G2_10, MTCI364_8, MTV049_28, MTV049_29, etc. TBparse score is 0.923.; PPE family protein	3501794..3502936	Mycobacterium tuberculosis H37Rv	888835
NP_217653.1	CDS	Rv3137	NC_000962.2	3503393	3504175	D	Rv3137, (MTCY03A2.21c), len: 260 aa. Probable monophosphatase (EC 3.1.3.-), equivalent to O32889|MLCB1779_19|ML0662 PUTATIVE MONOPHOSPHATASE from Mycobacterium leprae (255 aa), FASTA scores: opt: 1403, E(): 1.2e-81, (81.8% identity in 253 aa overlap). Also similar to Q9K4B1|SC7E4.05c from Streptomyces coelicolor (266 aa), FASTA scores: opt: 969, E(): 3.5e-54, (57.9% identity in 259 aa overlap); Q53743|PUR3 MONO-PHOSPHATASE from Streptomyces lipmanii (Streptomyces alboniger) (273 aa), FASTA scores: opt: 862, E(): 2.1e-47, (55.25% identity in 257 aa overlap); BAB50023|MLL3039 MONO-PHOSPHATASE from Rhizobium loti (Mesorhizobium loti) (262 aa), FASTA scores: opt: 448, E(): 3.2e-21, (31.37% identity in 255 aa overlap); etc. Contains inositol monophosphatase family signature 1 (PS00629). TBparse score is 0.881.; monophosphatase	3503393..3504175	Mycobacterium tuberculosis H37Rv	888827
NP_217654.1	CDS	pflA	NC_000962.2	3504195	3505283	D	Rv3138, (MTCY03A2.20c), len: 362 aa. Probable pflA, pyruvate formate lyase activating protein (EC 1.97.1.4), similar to other e.g. Q9V0N1|PAB1859 from Pyrococcus abyssi (348 aa), FASTA scores: opt: 926, E(): 1.1e-52, (39.95% identity in 343 aa overlap); O27446|MTH1395 from Methanobacterium thermoautotrophicum (335 aa), FASTA scores: opt: 909, E(): 1.3e-51, (42.2% identity in 327 aa overlap); O28939|AF1330 from Archaeoglobus fulgidus (336 aa), FASTA scores: opt: 884, E(): 5.6e-50, (42.0% identity in 319 aa overlap); etc. Also similar to O50099|PH1391 HYPOTHETICAL 40.2 KDA PROTEIN from Pyrococcus horikoshii (348 aa), FASTA scores: opt: 934, E(): 3.3e-53, (40.5% identity in 343 aa overlap); and other hypothetical proteins. TBparse score is 0.881.; pyruvate formate lyase activating protein PflA	3504195..3505283	Mycobacterium tuberculosis H37Rv	887973
NP_217655.1	CDS	fadE24	NC_000962.2	3505363	3506769	D	Rv3139, (MTCY03A2.19c), len: 468 aa. Probable fadE24, acyl-CoA dehydrogenase (1.3.99.-), equivalent to O32890|MLCB1779.30|FADE24|ML0661 PUTATIVE ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (465 aa), FASTA scores: opt: 2587, E(): 4e-153, (83.6% identity in 464 aa overlap). Similar to other e.g. Q9HUH0|PA4995 from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 1139, E(): 2.8e-63, (45.3% identity in 426 aa overlap); Q9K6D0|MMGC|BH3799 from Bacillus halodurans (379 aa), FASTA scores: opt: 603, E(): 4.7e-30, (30.3% identity in 366 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 601, E(): 6.3e-30, (32.25% identity in 363 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 2 (PS00073) near C-terminus. BELONGS TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.881.; acyl-CoA dehydrogenase FADE24	3505363..3506769	Mycobacterium tuberculosis H37Rv	887971
NP_217656.1	CDS	fadE23	NC_000962.2	3506790	3507995	D	Rv3140, (MTCY03A2.18c), len: 401 aa. Probable fadE23, acyl-CoA dehydrogenase (1.3.99.-) (see citation below), equivalent to O32891|MLCB1779.31|FADE23|ML0660 PUTATIVE ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (400 aa), FASTA scores: opt: 2307, E(): 3e-136, (89.5% identity in 401 aa overlap). Also similar to others e.g. Q9HUH1|PA4994 from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: 1558, E(): 1.2e-89, (61.0% identity in 400 aa overlap); O31251 from Acinetobacter sp. ADP1 (401 aa), FASTA scores: opt: 1509, E(): 1.3e-86, (58.2% identity in 402 aa overlap); Q9K6D1|ACDA OR BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 612, E(): 8.4e-31, (38.2% identity in 293 aa overlap); Q9AHX9|FADFX from Pseudomonas putida (375 aa), FASTA scores: opt: 584, E(): 4.6e-29, (32.7% identity in 379 aa overlap); etc. COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.890.; acyl-CoA dehydrogenase FADE23	3506790..3507995	Mycobacterium tuberculosis H37Rv	887417
NP_217657.1	CDS	fadB4	NC_000962.2	3508095	3509066	D	Rv3141, (MTCY03A2.17c), len: 323 aa. Probable fadB4, quinone oxidoreductase (EC 1.6.5.5), showing strong similarity to variety of quinone oxidoreductases and domains in polyketide and fatty acid synthases e.g. Q9HTV6|PA5234 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (325 aa), FASTA scores: opt: 737, E(): 1.4e-35, (39.65% identity in 328 aa overlap); Q9RYQ7|DRA0251 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans (336 aa), FASTA scores: opt: 688, E(): 1e-32, (40.6% identity in 325 aa overlap); Q9RVG8|DR1061 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans (388 aa), FASTA scores: opt: 559, E(): 3.3e-25, (36.3% identity in 325 aa overlap); BAB49685|MLL2594 PROBABLE QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (326 aa), FASTA scores: opt: 519, E(): 5.9e-23, (34.25% identity in 330 aa overlap); Q9LXZ4|T5P19_110 QUINONE REDUCTASE-LIKE PROTEIN from Arabidopsis thaliana (348 aa), FASTA scores: opt: 517, E(): 8.1e-23, (33.55% identity in 322 aa overlap); etc. Also similar to Q9AA38|CC0770 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from Caulobacter crescentus (325 aa), FASTA scores: opt: 673, E(): 7.2e-32, (40.2% identity in 326 aa overlap); and Q9ABX4|CC0096 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from Caulobacter crescentus (332 aa), FASTA scores: opt: 623, E(): 5.7e-29, (40.7% identity in 334 aa overlap). Also resembles Mycobacterium tuberculosis proteins P96826|Rv0149|MTCI5_23, MTCY13D12.11, MTCY24G1.03, MTCY19H9.01. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY. TBparse score is 0.904. Thought to be differentially expressed within host cells (see Triccas et al., 1999).; NADPH quinone oxidoreductase	3508095..3509066	Mycobacterium tuberculosis H37Rv	888051
NP_217658.1	CDS	Rv3142c	NC_000962.2	3509118	3509546	R	Rv3142c, (MTCY03A2.16), len: 142 aa. Hypothetical unknown protein. Equivalent to AAK47569 from Mycobacterium tuberculosis strain CDC1551 but shorter 33 aa. TBparse score is 0.921.; hypothetical protein	complement(3509118..3509546)	Mycobacterium tuberculosis H37Rv	887521
NP_217659.1	CDS	Rv3143	NC_000962.2	3509654	3510055	D	Rv3143, (MTCY03A2.15c), len: 133 aa. Probable response regulator, similar to other sensory transduction regulatory proteins e.g. Q9X810|SC6G10.25 from Streptomyces coelicolor (133 aa), FASTA scores: opt: 474, E(): 2.8e-24, (54.15% identity in 120 aa overlap); Q9KZ82|SCE25.04c from Streptomyces coelicolor (225 aa), FASTA scores: opt: 144, E(): 0.016, (32.3% identity in 127 aa overlap); Q9RZT4|DRB0029 from Deinococcus radiodurans (416 aa), FASTA scores: opt: 145, E(): 0.024, (30.65% identity in 124 aa overlap). SIMILAR TO OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS.; response regulator	3509654..3510055	Mycobacterium tuberculosis H37Rv	887576
YP_177936.1	CDS	PPE52	NC_000962.2	3510088	3511317	R	Rv3144c, (MTCY03A2.14), len: 409 aa. Member of the Mycobacterium tuberculosis PPE family, Gly-, Ala-rich, similar to others e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 1007, E(): 5.2e-35, (56.2% identity in 306 aa overlap); and MTV014_3, MTCY6G11_5, MTCY98.0034c, MTCY31.06c, MTCY48.17, MTCY98.0029c, MTCY03C7.17c, etc. TBparse score is 0.891.; PPE family protein	complement(3510088..3511317)	Mycobacterium tuberculosis H37Rv	887930
NP_217661.1	CDS	nuoA	NC_000962.2	3511682	3512068	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A	3511682..3512068	Mycobacterium tuberculosis H37Rv	887397
NP_217662.1	CDS	nuoB	NC_000962.2	3512077	3512631	D	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B	3512077..3512631	Mycobacterium tuberculosis H37Rv	888791
NP_217663.1	CDS	nuoC	NC_000962.2	3512628	3513338	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C	3512628..3513338	Mycobacterium tuberculosis H37Rv	888816
NP_217664.1	CDS	nuoD	NC_000962.2	3513338	3514660	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D	3513338..3514660	Mycobacterium tuberculosis H37Rv	888851
NP_217665.1	CDS	nuoE	NC_000962.2	3514657	3515415	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E	3514657..3515415	Mycobacterium tuberculosis H37Rv	887903
NP_217666.1	CDS	nuoF	NC_000962.2	3515412	3516749	D	Rv3150, (MTCY03A2.08c), len: 445 aa. Probable nuoF, NADH dehydrogenase, chain F (EC 1.6.5.3), similar to others e.g. Q9XAQ9|NUOF_STRCO from Streptomyces coelicolor (449 aa), FASTA scores: opt: 2314, E(): 3.5e-139, (76.25% identity in 434 aa overlap); NUF2_RHIME from Rhizobium meliloti (421 aa), FASTA scores: opt: 1545, E(): 1.8e-90, (53.1% identity in 424 aa overlap); Q9RU92|DR1500 from Deinococcus radiodurans (444 aa), FASTA scores: opt: 1445, E(): 4.1e-84, (52.9% identity in 427 aa overlap); etc. Contains respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2 (PS00645). BELONGS TO THE COMPLEX I 51 KDA SUBUNIT FAMILY. COFACTOR: FMN AND ONE 4FE-4S CLUSTER (PROBABLE). TBparse score is 0.889.; NADH dehydrogenase I chain F	3515412..3516749	Mycobacterium tuberculosis H37Rv	888854
NP_217667.1	CDS	nuoG	NC_000962.2	3516746	3519166	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G	3516746..3519166	Mycobacterium tuberculosis H37Rv	887540
NP_217668.1	CDS	nuoH	NC_000962.2	3519282	3520514	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H	3519282..3520514	Mycobacterium tuberculosis H37Rv	887531
NP_217669.1	CDS	nuoI	NC_000962.2	3520507	3521142	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I	3520507..3521142	Mycobacterium tuberculosis H37Rv	887530
NP_217670.1	CDS	nuoJ	NC_000962.2	3521139	3521927	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J	3521139..3521927	Mycobacterium tuberculosis H37Rv	888762
NP_217671.1	CDS	nuoK	NC_000962.2	3521924	3522223	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K	3521924..3522223	Mycobacterium tuberculosis H37Rv	888764
NP_217672.1	CDS	nuoL	NC_000962.2	3522234	3524135	D	Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L	3522234..3524135	Mycobacterium tuberculosis H37Rv	888063
NP_217673.1	CDS	nuoM	NC_000962.2	3524132	3525793	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M	3524132..3525793	Mycobacterium tuberculosis H37Rv	888765
NP_217674.1	CDS	nuoN	NC_000962.2	3525790	3527385	D	Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N	3525790..3527385	Mycobacterium tuberculosis H37Rv	888780
YP_177937.1	CDS	PPE53	NC_000962.2	3527391	3529163	R	Rv3159c, (MTV014.03c), len: 590 aa. Member of the Mycobacterium tuberculosis PPE_family of Gly-, Asn-rich proteins. Highly similar to P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 2289, E(): 3.2e-98, (63.5% identity in 600 aa overlap); and also similar to MTCY48_17, MTV041_29, MTCY6G11_5, MTCY98_24, etc. TBparse score is 0.921.; PPE family protein	complement(3527391..3529163)	Mycobacterium tuberculosis H37Rv	888794
NP_217676.1	CDS	Rv3160c	NC_000962.2	3529338	3529979	R	Rv3160c, (MTV014.04c), len: 213 aa. Possible transcriptional regulator, with some similarity to others e.g. Q9S3L4|AMTR AMTR PROTEIN (global repressor in the nitrogen regulation system; see Jakoby et al., 2000) (222 aa), FASTA scores: opt: 182, E(): 7.3e-05, (27.9% identity in 208 aa overlap); Q9X7X9|SC6A5.33c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (223 aa), FASTA scores: opt: 176, E(): 0.00018, (26.5% identity in 185 aa overlap); Q9XA31|SCH69.03c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (209 aa), FASTA scores: opt: 173, E(): 0.00027, (27.25% identity in 176 aa overlap); BAB54133|MLL7734 TRANSCRIPTIONAL REGULATOR from Rhizobium loti (Mesorhizobium loti) (213 aa), FASTA scores: opt: 172, E(): 0.00031, (23.55% identity in 204 aa overlap); etc. Also similar to hypothetical proteins from Mycobacterium tuberculosis strain H37Rv e.g. P96839|Rv3557v|MTCY06G11.04c (200 aa), FASTA scores: opt: 169, E(): 0.00046, (26.75% identity in 157 aa overlap). Contains probable helix-turn-helix motif from aa 31 to 52 (Score 1857, +5.51 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.901.; TetR family transcriptional regulator	complement(3529338..3529979)	Mycobacterium tuberculosis H37Rv	888797
NP_217677.1	CDS	Rv3161c	NC_000962.2	3529990	3531138	R	Rv3161c, (MTV014.05c), len: 382 aa. Possible dioxygenase (EC 1.-.-.-), similar to subunit of several dioxygenases and related proteins e.g. BAB50510|MLR3662 DIOXYGENASE, ALPHA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (400 aa), FASTA scores: opt: 413, E(): 6.2e-20, (28.4% identity in 331 aa overlap); Q9A3T0|CC3122 RIESKE 2FE-2S FAMILY PROTEIN from Caulobacter crescentus (404 aa), FASTA scores: opt: 405, E(): 2.1e-19, (27.95% identity in 372 aa overlap); Q9HTF4|PA5410 PROBABLE RING HYDROXYLATING DIOXYGENASE, ALPHA-SUBUNIT from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 392, E(): 1.6e-18, (25.8% identity in 399 aa overlap); Q9AGK6|PHTAA PHTHALATE DIOXYGENASE LARGE SUBUNIT from Arthrobacter keyseri (473 aa), FASTA scores: opt: 385, E(): 5.2e-18, (34.0% identity in 206 aa overlap); P76253|YEAW_ECOLI PUTATIVE DIOXYGENASE, ALPHA SUBUNIT from Escherichia coli (374 aa), FASTA scores: opt: 376, E(): 1.7e-17, (27.05% identity in 344 aa overlap); etc. TBparse score is 0.932.; dioxygenase	complement(3529990..3531138)	Mycobacterium tuberculosis H37Rv	888800
NP_217678.1	CDS	Rv3162c	NC_000962.2	3531208	3531645	R	Rv3162c, (MTV014.06c), len: 145 aa. Possible integral membrane protein, with some similarity to C-terminal part of Q10803|Rv2877c|MTCY274.08c hypothetical protein from Mycobacterium tuberculosis (287 aa), FASTA scores: opt: 112, E(): 6.9, (29.65% identity in 135 aa overlap); and other hypothetical proteins from other organisms. TBparse score is 0.924.; integral membrane protein	complement(3531208..3531645)	Mycobacterium tuberculosis H37Rv	888756
NP_217679.1	CDS	Rv3163c	NC_000962.2	3531642	3532913	R	Rv3163c, (MTV014.07c), len: 423 aa. Possible conserved secreted protein, with some similarity to other hypothetical bacterial proteins e.g. Q9Z539|SC9B2.20c from Streptomyces coelicolor (460 aa), FASTA scores: opt: 666, E(): 1.5e-33, (33.55% identity in 417 aa overlap); O58486|PH0774 from Pyrococcus horikoshii (410 aa), FASTA scores: opt: 329, E(): 6.9e-13, (23.8% identity in 424 aa overlap); Q9UZ66|PAB0849 from Pyrococcus abyssi (410 aa), FASTA scores: opt: 322, E(): 1.9e-12, (24.15% identity in 389 aa overlap); etc. Also some similarity with P71761|Rv1480|MTV007.27|MTCY277.01 from Mycobacterium tuberculosis (317 aa), FASTA scores: opt: 198, E(): 6.3e-05, (26.75% identity in 269 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.; hypothetical protein	complement(3531642..3532913)	Mycobacterium tuberculosis H37Rv	888789
NP_217680.1	CDS	moxR3	NC_000962.2	3532943	3533905	R	Rv3164c, (MTV014.08c), len: 320 aa. Probable moxR3, methanol dehydrogenase regulatory protein, highly similar to Q9Z538|SC9B2.21c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (332 aa), FASTA scores: opt: 1227, E(): 1.7e-67, (60.25% identity in 302 aa overlap); Q9UZ67|MOXR-3|PAB0848 METHANOL DEHYDROGENASE REGULATORY PROTEIN from Pyrococcus abyssi (314 aa), FASTA scores: opt: 1126, E(): 2.3e-61, (54.1% identity in 305 aa overlap); Q9HSH7|MOXR|VNG0223G METHANOL DEHYDROGENASE REGULATORY PROTEIN from Halobacterium sp. strain NRC-1 (318 aa), FASTA scores: opt: 1072, E(): 4.5e-58, (51.45% identity in 315 aa overlap); Q9RVV4|DR0918 MOXR-RELATED PROTEIN from Deinococcus radiodurans (354 aa), FASTA scores: opt: 1000, E(): 1.2e-53, (50.95% identity in 318 aa overlap); etc. Also high similarity with several hypothetical bacterial proteins. TBparse score is 0.917.; methanol dehydrogenase transcriptional regulatory protein MoxR3	complement(3532943..3533905)	Mycobacterium tuberculosis H37Rv	887658
NP_217681.1	CDS	Rv3165c	NC_000962.2	3533913	3534395	R	Rv3165c, (MTV014.09)c, len: 160 aa. Hypothetical unknown protein. TBparse score is 0.928.; hypothetical protein	complement(3533913..3534395)	Mycobacterium tuberculosis H37Rv	887661
NP_217682.1	CDS	Rv3166c	NC_000962.2	3534392	3535351	R	Rv3166c, (MTV014.10c), len: 319 aa. Probable transmembrane protein, similar but longer (52 aa) to O32895|MLCB1779.35c hypothetical protein from Mycobacterium leprae (119 aa), FASTA scores: opt: 289, E(): 3.7e-10, (44.25% identity in 122 aa overlap). Also some similarity to Q9Z536|SC9B2.23c PUTATIVE TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (339 aa), FASTA scores: opt: 247, E(): 2.5e-07, (28.2% identity in 326 aa overlap); and in N-terminus to Q9RS20|DR2307 PUTATIVE MULTIDRUG-EFFLUX TRANSPORTER from Deinococcus radiodurans (410 aa), FASTA scores: opt: 135,E(): 1, (32.35% identity in 136 aa overlap). TBparse score is 0.934.; hypothetical protein	complement(3534392..3535351)	Mycobacterium tuberculosis H37Rv	888750
NP_217683.1	CDS	Rv3167c	NC_000962.2	3535431	3536057	R	Rv3167c, (MTV014.11c), len: 208 aa. Probable transcriptional regulator, tetR family, similar to several transcriptional regulators e.g. Q9L2A4|SC8F4.22c (TETR/ACRR FAMILY) from Streptomyces coelicolor (234 aa), FASTA scores: opt: 317, E(): 7.5e-13, (33.35% identity in 210 aa overlap); Q9RK47|SCF12.11 (TETR/ACRR FAMILY) from Streptomyces coelicolor (206 aa), FASTA scores: opt: 293, E(): 2.1e-11, (32.65% identity in 199 aa overlap); Q54288 REGULATOR OF ANTIBIOTIC TRANSPORT COMPLEXES (TETR/ACRR FAMILY) (204 aa), FASTA scores: opt: 260, E(): 2.4e-09, (30.75% identity in 205 aa overlap); etc. Equivalent to AAK47595 from Mycobacterium tuberculosis strain CDC1551 but shorter 21 aa. Contains probable helix-turn-helix motif from aa 42 to 63 (Score 1727, +5.07 SD). MAY BE BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.871.; TetR family transcriptional regulator	complement(3535431..3536057)	Mycobacterium tuberculosis H37Rv	888763
NP_217684.1	CDS	Rv3168	NC_000962.2	3536102	3537238	D	Rv3168, (MTV014.12), len: 378 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. Q9M7Y6|F3E22.6 from Arabidopsis thaliana (Mouse-ear cress) (314 aa), FASTA scores: opt: 236, E(): 1.1e-07, (27.35% identity in 234 aa overlap); Q9RYW2|DRA0194 from Deinococcus radiodurans (386 aa), FASTA scores: opt: 207, E(): 9.1e-06, (23.45% identity in 320 aa overlap); etc. Also some similarity with O69727|Rc3761c|MTV025.109c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (351 aa), FASTA scores: opt: 193, E(): 6.4e-05, (29.4% identity in 242 aa overlap). TBparse score is 0.907.; hypothetical protein	3536102..3537238	Mycobacterium tuberculosis H37Rv	888778
NP_217685.1	CDS	Rv3169	NC_000962.2	3537238	3538362	D	Rv3169, (MTV014.13), len: 374 aa. Conserved hypothetical protein, with similarity to other hypothetical proteins: Q9A8W6|CC1232 from Caulobacter crescentus (368 aa), FASTA scores: opt: 669, E(): 3.3e-34, (34.05% identity in 376 aa overlap); and O32901|MLCB1779.41 from Mycobacterium leprae (127 aa), FASTA scores: opt: 179, E(): 0.00034, (29.0% identity in 131 aa overlap). Also weak similarity with P95149|Rv1866|MTCY359.07c (804 aa), FASTA scores: opt: 121, E(): 6.4, (37.0% identity in 119 aa overlap). Equivalent to AAK47597 from Mycobacterium tuberculosis strain CDC1551 but shorter 43 aa. TBparse score is 0.890.; hypothetical protein	3537238..3538362	Mycobacterium tuberculosis H37Rv	888774
NP_217686.1	CDS	aofH	NC_000962.2	3538505	3539851	D	Rv3170, (MT3259, MTV014.14), len: 448 aa. Probable aofH, flavin-containing (mono)amine oxidase (EC 1.4.3.4), equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below), and similar to many eukaryotic monoamine oxidases e.g. P49253|AOF_ONCMY from Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) (522 aa), FASTA scores: opt: 869, E(): 5.3e-44, (37.7% identity in 448 aa overlap); P21396|AOFA_RAT|MAOA from Rattus norvegicus (Rat) (526 aa), FASTA scores: opt: 839, E(): 3.2e-42, (37.45% identity in 446 aa overlap); Q99NA8|MAO-A from Cavia porcellus (Guinea pig) (506 aa), FASTA scores: opt: 836, E(): 4.6e-42, (37.0% identity in 446 aa overlap); P21398|AOFA_BOVIN from Bos taurus (Bovine) (527 aa), FASTA scores: opt: 806, E(): 2.8e-40, (37.0% identity in 446 aa overlap); P21397|AOFA_HUMAN (527 aa), FASTA scores: opt: 801, E(): 5.6e-40, (37.2% identity in 446 aa overlap); etc. Alternative start possible at position 3538487. BELONGS TO THE FLAVIN MONOAMINE OXIDASE FAMILY. COFACTOR: FAD (POTENTIAL). TBparse score is 0.900.; flavin-containing monoamine oxidase	3538505..3539851	Mycobacterium tuberculosis H37Rv	888754
NP_217687.1	CDS	hpx	NC_000962.2	3539846	3540745	R	Rv3171c, (MTV014.15c), len: 299 aa. Possible hpx, non-heme haloperoxidase (EC 1.11.1.-), similar to other hydrolases (principaly epoxide hydrolases) and non-heme chloroperoxidases e.g. Q9RKB6|SCE87.22c PUTATIVE HYDROLASE from Streptomyces coelicolor (314 aa), FASTA scores: opt: 431, E(): 6e-20, (38.05% identity in 297 aa overlap); Q9HZ14|PA3226 PROBABLE HYDROLASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Pseudomonas aeruginosa (275 aa), FASTA scores: opt: 236, E(): 1e-07, (29.6% identity in 277 aa overlap); Q9DBL9|1300003 D03RIK PROTEIN SIMILAR TO ALPHA/BETA HYDROLASE FOLD from Mus musculus (Mouse) (351 aa), FASTA scores: opt: 223, E(): 8.3e-07, (24.35% identity in 304 aa overlap); AAK46260|MT1988 EPOXIDE HYDROLASE from Mycobacterium tuberculosis strain CDC1551 (356 aa), FASTA scores: opt: 223, E(): 8.4e-07, (40.7% identity in 113 aa overlap); P49323|PRXC_STRLI|CPO|CPOL NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) from Streptomyces lividans (275 aa), FASTA scores: opt: 220, E(): 1e-06, (29.5% identity in 305 aa overlap); etc. Equivalent to AAK47599 Hydrolase, alpha/beta hydrolase family from Mycobacterium tuberculosis strain CDC1551 but shorter 24 aa. Start chosen by similarity, alternative with good RBS possible. TBparse score is 0.907.; non-Heme haloperoxidase Hpx	complement(3539846..3540745)	Mycobacterium tuberculosis H37Rv	887293
NP_217688.1	CDS	Rv3172c	NC_000962.2	3540882	3541364	R	Rv3172c, (MTV014.16c), len: 160 aa. Hypothetical unknown protein.; hypothetical protein	complement(3540882..3541364)	Mycobacterium tuberculosis H37Rv	888848
NP_217689.1	CDS	Rv3173c	NC_000962.2	3541443	3542045	R	Rv3173c, (MTV014.17c), len: 200 aa. Probable transcriptional regulatory protein tetR family, similar to several bacterial putative regulatory proteins e.g. Q9EWI2|SC7H9.14 from Streptomyces coelicolor (195 aa), FASTA scores: opt: 319, E(): 1.7e-13, (34.55% identity in 195 aa overlap); O85695|3SCF60.04 from Streptomyces lividans and Streptomyces coelicolor (192 aa), FASTA scores: opt: 297, E(): 4.3e-12, (37.45% identity in 187 aa overlap); BAB50853|MLR4117 from Rhizobium loti (Mesorhizobium loti) (205 aa), FASTA scores: opt: 280, E(): 5.5e-11, (31.45% identity in 194 aa overlap); BAB53760|MLL8133 from Rhizobium loti (Mesorhizobium loti) (194 aa), FASTA scores: opt: 270, E(): 2.3e-10, (34.05% identity in 185 aa overlap); etc. Also similar to other regulators from Mycobacterium tuberculosis e.g. P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt: 154, E(): 0.0013, (38.8% identity in 80 aa overlap). Contains probable helix-turn-helix motif from aa 39 to 60 (Score 1251, +3.45 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.925.; TetR/ACRR family transcriptional regulator	complement(3541443..3542045)	Mycobacterium tuberculosis H37Rv	888844
NP_217690.1	CDS	Rv3174	NC_000962.2	3542138	3542845	D	Rv3174, (MTV014.18), len: 235 aa. Probable oxidoreductase short-chain dehyrogenase/reductase (EC 1.-.-.-), similar to others e.g. Q9RPT7|SITS from Streptomyces albus (223 aa), FASTA scores: opt: 654, E(): 6.1e-32, (49.3% identity in 215 aa overlap); Q9RI61|SCJ11.46 from Streptomyces coelicolor (230 aa), FASTA scores: opt: 626, E(): 2.9e-30, (50.9% identity in 224 aa overlap); Q9A5Z1|CC2306 from Caulobacter crescentus (252 aa), FASTA scores: opt: 430, E(): 1.3e-18, (39.45% identity in 228 aa overlap); Q51641 INSECT-TYPE DEHYDROGENASE (249 aa), FASTA scores: opt: 301, E(): 5.7e-11, (38.3% identity in 188 aa overlap); Q9HXC9|PA3883 from Pseudomonas aeruginosa (276 aa), FASTA scores: opt: 296, E(): 1.2e-10, (29.55% identity in 247 aa overlap); etc. MAY BE BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is 0.900.; short chain dehydrogenase	3542138..3542845	Mycobacterium tuberculosis H37Rv	887989
NP_217691.1	CDS	Rv3175	NC_000962.2	3542860	3544347	D	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase	3542860..3544347	Mycobacterium tuberculosis H37Rv	887294
YP_177938.1	CDS	mesT	NC_000962.2	3544344	3545300	R	Rv3176c, (MTV014.20c), len: 318 aa. Probable mesT, epoxide hydrolase (EC 3.3.2.3), similar to others e.g. O15007|PEG1|MEST|Q92571|O14973 MEST PROTEIN (MESODERM SPECIFIC TRANSCRIPT (MOUSE) HOMOLOG) (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Homo sapiens (Human) (335 aa), FASTA scores: opt: 348, E(): 6e-15, (32.15% identity in 280 aa overlap); AAH06639|Q07646 MEST PROTEIN from Mus musculus (Mouse) (335 aa), FASTA scores: opt: 342, E(): 1.4e-14, (31.45% identity in 280 aa overlap); Q9I8E7|MEST EPOXIDE HYDROLASE (EC 3.3.2.3) from Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) (326 aa), FASTA scores: opt: 322, E(): 2.7e-13, (29.55% identity in 301 aa overlap); Q9PUC9|PEG1|MEST EPOXIDE HYDROLASE from Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa), FASTA scores: opt: 322, E(): 2.8e-13, (32.35% identity in 207 aa overlap); Q9HYH6|PA3429 PROBABLE EPOXIDE HYDROLASE from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 258, E(): 3e-09, (29.85% identity in 288 aa overlap); O31243|ECHA EPOXIDE HYDROLASE from Agrobacterium radiobacter (294 aa), FASTA scores: opt: 202, E(): 1.1e-05, (27.0% identity in 278 aa overlap); etc. Also similar to Q50599|Rv1834|MT1882|MTCY1A11.09c HYPOTHETICAL 31.7 KDA PROTEIN from Mycobacterium tuberculosis (288 aa), FASTA scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa overlap). Equivalent to AAK47604 from Mycobacterium tuberculosis strain CDC1551 (339 aa) but shorter 21 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. MAY BE BELONG TO PEPTIDASE FAMILY S33. Note that previously known as lipS. TBparse score is 0.911.; lipS; epoxide hydrolase MesT	complement(3544344..3545300)	Mycobacterium tuberculosis H37Rv	888846
NP_217693.1	CDS	Rv3177	NC_000962.2	3545447	3546307	D	Rv3177, (MTV014.21), len: 286 aa. Possible peroxidase (non-haem peroxidase) (EC 1.11.1.-), highly similar to Q9KJF9|W78 CULTIVAR SPECIFICITY PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) W78 from Rhizobium leguminosarum (287 aa), FASTA scores: opt: 1059, E(): 2.3e-59, (61.4% identity in 272 aa overlap); BAB48728|MLL1328 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 746, E(): 1.1e-39, (43.25% identity in 282 aa overlap). Similar to nonheme chloroperoxidases and related esterases e.g. O73957|SAL LIPOLYTIC ENZYME from Sulfolobus acidocaldarius (314 aa), FASTA scores: opt: 408, E(): 1.9e-18, (32.4% identity in 287 aa overlap); Q9AJM9|BIOH PROTEIN INVOLVED IN BIOTIN SYNTHESIS from Kurthia sp. 538-KA26 (267 aa), FASTA scores: opt: 324 ,E(): 3.2e-13, (30.0% identity in 250 aa overlap); Q9CBB1|ML2269 PUTATIVE HYDROLASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Mycobacterium leprae (265 aa); O05691|THCF_RHOER NON-HEME HALOPEROXIDASE (EC 1.11.1.-) from Rhodococcus erythropolis (SIMILAR TO OTHER BACTERIAL NON-HEME BROMO- AND CHLORO-PEROXIDASES) (274 aa), FASTA scores: opt: 279, E(): 2.2e-10, (29.0% identity in 276 aa overlap); Q53540|EST ESTERASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Pseudomonas putida (276 aa), FASTA scores: opt: 271, E(): 7.1e-10, (29.65% identity in 280 aa overlap); etc. Also similar to O06420|BPOC|Rv0554|MTCY25D10.33 HYPOTHETICAL 28.3 KDA PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from M. tuberculosis (262 aa), FASTA scores: opt: 280 ,E(): 1.8e-10, (28.0% identity in 257 aa overlap). Equivalent to AAK47605 from Mycobacterium tuberculosis strain CDC1551 (300 aa) but shorter 14 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. TBparse score is 0.913.; peroxidase	3545447..3546307	Mycobacterium tuberculosis H37Rv	888766
NP_217694.1	CDS	Rv3178	NC_000962.2	3546438	3546797	D	Rv3178, (MTV014.22), len: 119 aa. Hypothetical protein, with some similarity to other hypothetical bacterial proteins (principaly mycobacterium and streptomyces proteins) e.g. P71854|Rv3547|MTCY03C7.09c from Mycobacterium tuberculosis strain H37Rv (151 aa), FASTA scores: opt: 310, E(): 2e-14, (40.5% identity in 116 aa overlap); Q9ZH81 from M. paratuberculosis (144 aa), FASTA scores: opt: 274, E(): 5.6e-12, (38.9% identity in 108 aa overlap); O85698|3SCF60.07 from Streptomyces lividans and Streptomyces coelicolor (149 aa), FASTA scores: opt: 235, E(): 2.7e-09, (35.2% identity in 108 aa overlap); Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c (148 aa); Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa); etc. Equivalent to AAK47606 from Mycobacterium tuberculosis strain CDC1551 (171 aa) but shorter 52 aa.; hypothetical protein	3546438..3546797	Mycobacterium tuberculosis H37Rv	888786
NP_217695.1	CDS	Rv3179	NC_000962.2	3547618	3548907	D	Rv3179, (MTV014.23), len: 429 aa. Conserved hypothetical protein, highly similar to Q9KH61 PUTATIVE ATP/GTP BINDING PROTEIN from Mycobacterium smegmatis (428 aa), FASTA scores: opt: 2466, E(): 1.5e-148, (89.7% identity in 428 aa overlap) (no article found on the NCBI web site (July 2001)); and to other hypothetical bacterial proteins e.g. O07781|Rv0597c|MTCY19H5.25 from M. tuberculosis (411 aa), FASTA scores: opt: 1031, E(): 8e-58, (41.5% identity in 417 aa overlap); BAB54715|MLR9349 from Rhizobium loti (Mesorhizobium loti) (435 aa), FASTA scores: opt: 365, E(): 1.1e-15, (31.75% identity in 416 aa overlap); etc. Equivalent to AAK47609 from Mycobacterium tuberculosis strain CDC1551 (454 aa) but shorter 25 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.923.; hypothetical protein	3547618..3548907	Mycobacterium tuberculosis H37Rv	887947
NP_217696.1	CDS	Rv3180c	NC_000962.2	3549254	3549688	R	Rv3180c, (MTV014.24c), len: 144 aa. Hypothetical unknown ala-rich protein. Contains probable coiled-coil domain from aa 40 to 70.; hypothetical protein	complement(3549254..3549688)	Mycobacterium tuberculosis H37Rv	887946
NP_217697.1	CDS	Rv3181c	NC_000962.2	3549691	3550143	R	Rv3181c, (MTV014.25c), len: 150 aa. Hypothetical protein, with some similarity to other mycobacterium proteins e.g. Q50718|YY07_MYCTU|Rv3407|MT3515|MTCY78.21c (99 aa), FASTA scores: opt: 123, E(): 0.25, (33.7% identity in 89 aa overlap); and O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: opt: 123, E(): 0.26, (39.7% identity in 68 aa overlap). TBparse score is 0.910.; hypothetical protein	complement(3549691..3550143)	Mycobacterium tuberculosis H37Rv	888787
NP_217698.1	CDS	Rv3182	NC_000962.2	3550374	3550718	D	Rv3182, (MTV014.26), len: 114 aa. Hypothetical protein, with some similarity to other hypothetical bacterial proteins e.g. O53468|Rv2022c|MTV018.09c from M. tuberculosis (201 aa), FASTA scores: opt: 335, E(): 3.6e-16, (51.9% identity in 104 aa overlap); and Q9L3R6|ORF119 from Anabaena sp. strain PCC 7120 (119 aa), FASTA scores: opt: 250, E(): 1.6e-10, (42.1% identity in 95 aa overlap). Equivalent to AAK47614 from Mycobacterium tuberculosis strain CDC1551 (94 aa) but longer 20 aa.; hypothetical protein	3550374..3550718	Mycobacterium tuberculosis H37Rv	888795
NP_217699.1	CDS	Rv3183	NC_000962.2	3550715	3551044	D	Rv3183, (MTV014.27), len: 109 aa. Possible transcriptional regulator, similar to others e.g. Q9S1D9|YPPCP1.08c from Yersinia pestis (99 aa), FASTA scores: opt: 119, E(): 0.47, (40.55% identity in 74 aa overlap); Q9X153|TM1330 from Thermotoga maritima (111 aa), FASTA scores: opt: 115, E(): 0.91, (40.35% identity in 57 aa overlap); P95258|Rv1956|MTCY09F9.08c (alias AAK46277 putative DNA-binding protein from strain CDC1551) (149 aa), FASTA scores: opt: 116, E(): 1, (42.25% identity in 71 aa overlap). Also similar to O53467|Rv2021c|MTV018.08c from Mycobacterium tuberculosis (101 aa), FASTA scores: opt: 214, E(): 5.8e-07, (43.0% identity in 107 aa overlap). Contains probable helix-turn-helix motif from aa 51 to 72 (Score 1803, +5.33 SD). TBparse score is 0.852.; transcriptional regulatory protein	3550715..3551044	Mycobacterium tuberculosis H37Rv	888059
NP_217700.1	CDS	Rv3184	NC_000962.2	3551281	3551607	D	Rv3184, (MTV014.28), len: 108 aa. Probable IS6110 transposase. TBparse score is 0.928.; transposase	3551281..3551607	Mycobacterium tuberculosis H37Rv	888796
NP_217701.1	CDS	Rv3185	NC_000962.2	<3551604	3552542	D	Rv3185, (MTV014.29), len: 312 aa. Probable IS6110 transposase. TBparse score is 0.926.; transposase	<3551604..3552542	Mycobacterium tuberculosis H37Rv	887441
NP_217702.1	CDS	Rv3186	NC_000962.2	3552764	3553090	D	Rv3186, (MTV014.30), len: 108 aa. Probable IS6110 transposase. TBparse score is 0.928.; transposase	3552764..3553090	Mycobacterium tuberculosis H37Rv	888024
NP_217703.1	CDS	Rv3187	NC_000962.2	<3553087	3554025	D	Rv3187, (MTV014.31), len: 312 aa. Probable IS6110 transposase.; transposase	<3553087..3554025	Mycobacterium tuberculosis H37Rv	887604
NP_217704.1	CDS	Rv3188	NC_000962.2	3554298	3554645	D	Rv3188, (MTV014.32), len: 115 aa. Conserved hypothetical protein, with similarity to other proteins from Mycobacterium tuberculosis: Q10868|YJ90_MYCTU|Rv1990c|MT2044|MTCY39.29 HYPOTHETICAL PROTEIN (113 aa), FASTA scores: opt: 184, E(): 8.1e-06, (28.45% identity in 109 aa overlap); and O06299|Rv0348|MTCY13E10.08 HYPOTHETICAL PROTEIN (217 aa), FASTA scores: opt: 129, E(): 0.074, (30.0% identity in 100 aa overlap). Also some similarity with C-terminus of Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (218 aa), FASTA scores: opt: 114, E(): 0.76, (30.0% identity in 110 aa overlap) (for this one, no similarity exists in the N-terminal region with the N-terminus of other regulatory components of sensory transduction systems). TBparse score is 0.881.; hypothetical protein	3554298..3554645	Mycobacterium tuberculosis H37Rv	888103
NP_217705.1	CDS	Rv3189	NC_000962.2	3554642	3555262	D	Rv3189, (MTV014.33), len: 206 aa. Conserved hypothetical protein, weakly similar to other proteins from Mycobacterium tuberculosis e.g. O86329|MBTE|Rv2380c|MTCY22H8.05 (1682 aa), FASTA scores: opt: 135, E(): 0.79, (27.8% identity in 187 aa overlap); and Q10869|YJ89_MYCTU|Rv1989c|MT2043MTCY39.30 (186 aa), FASTA scores: opt: 122, E(): 0.85, (32.25% identity in 93 aa overlap). TBparse score is 0.881.; hypothetical protein	3554642..3555262	Mycobacterium tuberculosis H37Rv	888034
NP_217706.1	CDS	Rv3190c	NC_000962.2	3555422	3556687	R	Rv3190c, (MTV014.34c), len: 421 aa. Hypothetical unknown protein. TBparse score is 0.937.; hypothetical protein	complement(3555422..3556687)	Mycobacterium tuberculosis H37Rv	888119
NP_217707.1	CDS	Rv3191c	NC_000962.2	3557311	3558345	R	Rv3191c, (MTV014.35c), len: 344 aa. Probable transposase, similar to many especially Q9K2N8 PUTATIVE TRANSPOSASE from Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 837, E(): 1.3e-43, (42.55% identity in 336 aa overlap); Q9RBF4 INSERTION SEQUENCE IS1088 from Alcaligenes eutrophus (Ralstonia eutropha) (342 aa), FASTA scores: opt: 823, E(): 9.2e-43, (43.05% identity in 337 aa overlap); and Q51379 PUTATIVE TRANSPOSASE from Pseudomonas alcaligenes (338 aa), FASTA scores: opt: 818, E(): 1.8e-42, (42.35% identity in 333 aa overlap). Contains probable helix-turn-helix motif from aa 25 to 46 (Score 1968, +5.89 SD).; transposase	complement(3557311..3558345)	Mycobacterium tuberculosis H37Rv	887628
NP_217708.1	CDS	Rv3192	NC_000962.2	3559563	3560024	D	Rv3192, (MTV014.36), len: 153 aa. Conserved hypothetical ala- and pro-rich protein, with weak similarity to N-terminal half of several proteins e.g. Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 HYPOTHETICAL 37.3 KDA PROTEIN from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 245, E(): 3.7e-08, (33.1% identity in 157 aa overlap); O30260|AF2411 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (363 aa), FASTA scores: opt: 144, E(): 0.072, (32.6% identity in 92 aa overlap); Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces violaceoruber (343 aa), FASTA scores: opt: 133, E(): 0.33, (25.15% identity in 159 aa overlap). TBparse score is 0.920.; hypothetical protein	3559563..3560024	Mycobacterium tuberculosis H37Rv	887899
NP_217709.1	CDS	Rv3193c	NC_000962.2	3560194	3563172	R	Rv3193c, (MTV014.37c), len: 992 aa. Probable conserved transmembrane protein, with hydrophobic N-terminal domain ( 1-340 aa), highly similar to Q9CCM6|ML0644 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (983 aa), FASTA scores: opt: 5421, E(): 0, (86.15% identity in 989 aa overlap); and O53609|Rv0064|MTV030.07 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis strain H37Rv (979 aa), FASTA scores: opt: 3204, E(): 2.1e-142, (50.25% identity in 985 aa overlap). C-terminal part (709-990 aa) highly similar to O32904|MLCB1779.46 HYPOTHETICAL 29.1 KDA PROTEIN from Mycobacterium leprae (277 aa), FASTA scores: opt: 1521, E(): 3.4e-64, (82.6% identity in 282 aa overlap). Also some similarity to hypothetical proteins generally transmembrane e.g. Q9FCI4|2SC3B6.28 from Streptomyces coelicolor (815 aa), FASTA scores: opt: 951, E(): 3.4e-37, (39.2% identity in 826 aa overlap); P72637|SLL1060 from Synechocystis sp. strain PCC 6803 (1032 aa), FASTA scores: opt: 938, E(): 1.6e-36, (29.95% identity in 855 aa overlap); O28851|AF1421 from Archaeoglobus fulgidus (880 aa), FASTA scores: opt: 526, E(): 2.6e-17, (28.05% identity in 970 aa overlap); etc.; hypothetical protein	complement(3560194..3563172)	Mycobacterium tuberculosis H37Rv	888012
NP_217710.1	CDS	Rv3194c	NC_000962.2	3563264	3564286	R	Rv3194c, (MTV014.38c), len: 340 aa. Possible conserved secreted protein (N-terminal stretch hydrophobic), equivalent to Q9CCM7|ML0643 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (340 aa), FASTA scores: opt: 1822, E(): 1.6e-102, (80.3% identity in 340 aa overlap). Also similar to other proteins e.g. Q9FCI6|2SC3B6.26 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (364 aa), FASTA scores: opt: 430, E(): 1.1e-18, (40.95% identity in 359 aa overlap); Q9S3Y5|SDRC SDRC PROTEIN from Streptomyces coelicolor (241 aa), FASTA scores: opt: 396, E(): 8.9e-17, (35.2% identity in 318 aa overlap) (similarity in part for this one); O34470|YLBL YLBL PROTEIN from Bacillus subtilis (350 aa), FASTA scores: opt: 385, E(): 5.6e-16, (27.7% identity in 350 aa overlap); etc. TBparse score is 0.890.; hypothetical protein	complement(3563264..3564286)	Mycobacterium tuberculosis H37Rv	888062
NP_217711.1	CDS	Rv3195	NC_000962.2	3564364	3565782	D	Rv3195, (MTV014.39), len: 472 aa. Hypothetical protein, equivalent to Q49746|ML0642|B1937_C3_231 HYPOTHETICAL 50.3 KDA PROTEIN from Mycobacterium leprae (479 aa), FASTA scores: opt: 2503, E(): 1e-138, (79.35% identity in 475 aa overlap). Similar in part to Q9FCI9|2SC3B6.23c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (487 aa), FASTA scores: opt: 1382, E(): 2.7e-73, (46.4% identity in 489 aa overlap); Q9X8I7|SCE9.14 HYPOTHETICAL 41.2 KDA PROTEIN from Streptomyces coelicolor (375 aa), FASTA scores: opt: 319, E(): 2.4e-11, (25.6% identity in 383 aa overlap); etc. TBparse score is 0.893.; hypothetical protein	3564364..3565782	Mycobacterium tuberculosis H37Rv	888900
NP_217712.1	CDS	Rv3196	NC_000962.2	3565788	3566687	D	Rv3196, (MTV014.40), len: 299 aa. Hypothetical protein, with some similarity to other hypothetical proteins e.g. Q9FCJ5|2SC3B6.17c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (442 aa), FASTA scores: opt: 233, E(): 3.5e-07, (29.9% identity in 261 aa overlap). TBparse score is 0.936.; hypothetical protein	3565788..3566687	Mycobacterium tuberculosis H37Rv	888903
YP_177939.1	CDS	Rv3196A	NC_000962.2	3566696	3566896	R	Rv3196A, len: 66 aa. Hypothetical unknown protein.; hypothetical protein	complement(3566696..3566896)	Mycobacterium tuberculosis H37Rv	3205082
NP_217713.1	CDS	Rv3197	NC_000962.2	3567024	3568367	D	Rv3197, (MTV014.41), len: 447 aa. Probable conserved ATP-binding protein ABC transporter, highly similar to Mycobacterium leprae proteins: Q9CCM8|ML0640 HYPOTHETICAL PROTEIN (473 aa), FASTA scores: opt: 2512, E(): 2.1e-140, (83.0% identity in 447 aa overlap). Interestingly, the N-terminal half (1-219 aa) corresponds to Q49747|ABC1|B1937_C3_233 ABC1 PROTEIN from Mycobacterium leprae (267 aa), FASTA scores: opt: 1276, E(): 6.3e-68, (88.6% identity in 219 aa overlap); and the C-terminal half (239-447 aa) corresponds to Q49745|B1937_C2_179 HYPOTHETICAL 23.1 KDA PROTEIN (206 aa), FASTA scores: opt: 1138, E(): 6.5e-60, (77.05% identity in 209 aa overlap); two adjacent orfs from Mycobacterium leprae. Also highly similar to other proteins (generally ABC transporters) e.g. Q9FCJ6|2SC3B6.16c HYPOTHETICAL 51.3 KDA PROTEIN from Streptomyces coelicolor (469 aa), FASTA scores: opt: 1340, E(): 1.8e-71, (45.9% identity in 449 aa overlap); O65576|ABC1AT ABC1 PROTEIN (alias Q9SBB2|T15B16.14|AT4G01660 PUTATIVE ABC TRANSPORTER) from Arabidopsis thaliana (Mouse-ear cress) (623 aa), FASTA scores: opt: 543, E(): 1.7e-24, (28.4% identity in 405 aa overlap); O27682|MTH1645 ABC TRANSPORTER from Methanobacterium thermoautotrophicum (623 aa), FASTA scores: opt: 497, E(): 7.8e-22, (33.0% identity in 309 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.892.; ABC transporter ATP-binding protein	3567024..3568367	Mycobacterium tuberculosis H37Rv	887858
YP_177940.1	CDS	whiB7	NC_000962.2	3568401	3568679	R	Rv3197A, len: 92 aa. Probable whiB7 (alternate gene name: whmC), WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q49765|WHIB7|ML0639|B1937_F2_68 PUTATIVE TRANSCRIPTIONAL REGULATOR WHIB7 from Mycobacterium leprae (89 aa), FASTA scores: opt: 441, E(): 6.3e-24, (69.3% identity in 88 aa overlap). Similar to Q9FCJ8|2SC3B6.14 PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (122 aa), FASTA scores: opt: 348, E(): 2.2e-17, (57.7% identity in 78 aa overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa), FASTA scores: opt: 166, E(): 7.1e-05, (39.4% identity in 76 aa overlap); etc.; whmC; transcriptional regulatory protein WHIB-like WHIB7	complement(3568401..3568679)	Mycobacterium tuberculosis H37Rv	3205083
NP_217714.1	CDS	uvrD2	NC_000962.2	3569109	3571211	R	Rv3198c, (MTV014.42c), len: 700 aa. Probable UvrD2, ATP dependent DNA helicase II (EC 3.6.1.-) (see citation below), equivalent to P53528|UVRD_MYCLE|VRD|UVRD2|ML0637|B1937_F1_27 PROBABLE DNA HELICASE II HOMOLOG from Mycobacterium leprae (714 aa), FASTA scores: opt: 3749, E(): 0, (82.85% identity in 706 aa overlap); and C-terminal half (466-700 aa) corresponds to Q49764|RECQ|B1937_F2_66 PUTATIVE DNA HELICASE RECQ (EC 3.6.1.-) (242 aa), FASTA scores: opt: 1267, E(): 1.4e-69, (82.5% identity in 234 aa overlap); products of two adjacent ORFS in Mycobacterium leprae. Also similar to other DNA helicases e.g. Q9FCK0|2SC3B6.12 from Streptomyces coelicolor (785 aa), FASTA scores: opt: 1687, E(): 1.2e-94, (52.05% identity in 728 aa overlap); P71561|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c ATP-DEPENDENT DNA HELICASE PCRA from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 715, E(): 1e-35, (34.1% identity in 710 aa overlap); Q9CD72|PCRA_MYCLE|UVRD|ML0153 ATP-DEPENDENT DNA HELICASE PCRA from Mycobacterium leprae (778 aa), FASTA scores: opt: 687, E(): 5.1e-34, (32.0% identity in 719 aa overlap); O83991|TP1028 DNA HELICASE II (UVRD) from Treponema pallidum (670 aa), FASTA scores: opt: 652, E(): 6e-32, (30.25% identity in 671 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES. TBparse score is 0.903.; ATP-dependent DNA helicase II UVRD2	complement(3569109..3571211)	Mycobacterium tuberculosis H37Rv	888902
YP_177941.1	CDS	Rv3198A	NC_000962.2	3571335	3571589	D	Rv3198A, len: 84 aa. Possible glutaredoxin protein (EC 1.-.-.-), highly similar to Q9FCK1|2SC3B6.11c PUTATIVE GLUTAREDOXIN-LIKE PROTEIN from Streptomyces coelicolor (80 aa), FASTA scores: opt: 293, E(): 2.2e-14, (55.15% identity in 78 aa overlap); and Q9RSN9|DR2085 PUTATIVE GLUTAREDOXIN from Deinococcus radiodurans (81 aa), FASTA scores: opt: 198, E(): 1.2e-07, (53.55% identity in 56 aa overlap). Also similar to several hypothetical bacterial proteins e.g. Q9X8C2|SCE36.09 HYPOTHETICAL 13.0 KDA PROTEIN from Streptomyces coelicolor (114 aa), FASTA scores: opt: 181, E(): 2.6e-06, (44.45% identity in 72 aa overlap).; glutaredoxin protein	3571335..3571589	Mycobacterium tuberculosis H37Rv	3205084
NP_217715.1	CDS	nudC	NC_000962.2	3571602	3572543	R	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase	complement(3571602..3572543)	Mycobacterium tuberculosis H37Rv	887860
NP_217716.1	CDS	Rv3200c	NC_000962.2	3572602	3573669	R	Rv3200c, (MTV014.44c), len: 355 aa. Possible transmembrane cation transporter, similar to many transmembrane proteins and putative potassium channels e.g. Q9XA52|SCGD3.27C PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (365 aa), FASTA scores: opt: 1022, E(): 2.6e-53, (49.85% identity in 325 aa overlap); Q9RRZ3|DR2336 PUTATIVE POTASSIUM CHANNEL from Deinococcus radiodurans (320 aa), FASTA scores: opt: 436, E(): 1e-18, (30.9% identity in 304 aa overlap); O28600|AF1673 PUTATIVE POTASSIUM CHANNEL from Archaeoglobus fulgidus (314 aa), FASTA scores: opt: 363, E(): 2.1e-14, (27.2% identity in 309 aa overlap); Q57604|Y13B_METJAMJ0138.1|MJ0138.1 PUTATIVE POTASSIUM CHANNEL from Methanococcus jannaschii (333 aa), FASTA scores: opt: 356, E(): 5.7e-14, (26.0% identity in 281 aa overlap); P73132|SLL0993 POTASSIUM CHANNEL from Synechocystis sp. strain PCC 6803 (365 aa), FASTA scores: opt: 330, E(): 2.1e-12, (27.8% identity in 324 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.904.; transmembrane cation transporter	complement(3572602..3573669)	Mycobacterium tuberculosis H37Rv	887543
NP_217717.1	CDS	Rv3201c	NC_000962.2	3573731	3577036	R	Rv3201c, (MTV014.45c), len: 1101 aa. Probable ATP-dependent DNA helicase (EC 3.6.1.-), similar to others e.g. Q9FCK4|2SC3B6.08 from Streptomyces coelicolor (1222 aa), FASTA scores: opt: 1209, E(): 5.4e-63, (38.45% identity in 1199 aa overlap); P71561|PCRA_MYCTU|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 403, E(): 6.5e-16, (28.15% identity in 717 aa overlap); Q9FCK5|2SC3B6.07 from Streptomyces coelicolor (1159 aa), FASTA scores: opt: 349, E(): 1.3e-12, (29.2% identity in 1144 aa overlap); Q9L3M1|UVRD from Prochlorococcus sp. (512 aa; fragment), FASTA scores: opt: 290, E(): 2e-09, (27.95% identity in 479 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.909.; ATP-dependent DNA helicase	complement(3573731..3577036)	Mycobacterium tuberculosis H37Rv	887663
NP_217718.1	CDS	Rv3202c	NC_000962.2	3577033	3580200	R	Rv3202c, (MTCY07D11.24, MTV014.46c), len: 1055 aa. Possible ATP-dependent DNA helicase (EC 3.6.1.-), showing some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 PUTATIVE ATP-DEPENDENT DNA HELICASE from Streptomyces coelicolor (1159 aa), FASTA scores: opt: 666, E(): 1e-29, (34.5% identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443 MISMATCH REPAIR PROTEIN MUTU (DNA HELICASE II) from Pseudomonas aeruginosa (728 aa), FASTA scores: opt: 239, E(): 7.3e-06, (23.8% identity in 677 aa overlap) (no similarity in C-terminal part for this one); etc. C-terminal region similar to Q9FDU2|ORF3 ORF3 PROTEIN (FRAGMENT) from Streptomyces griseus (551 aa), FASTA scores: opt: 800, E(): 1.7e-37, (36.2% identity in 525 aa overlap); and Q9ZG15 HYPOTHETICAL 35.5 KDA PROTEIN from Rhodococcus erythropolis (323 aa), FASTA scores: opt: 232, E(): 9.7e-06, (28.55% identity in 266 aa overlap).; ATP-dependent DNA helicase	complement(3577033..3580200)	Mycobacterium tuberculosis H37Rv	887574
NP_217719.1	CDS	lipV	NC_000962.2	3580638	3581312	D	Rv3203, (MTCY07D11.23c), len: 224 aa. Possible lipV, hydrolase lipase (EC 3.1.-.-), showing some similarity to other lipases e.g. Q9JSN0|NMA2216 PUTATIVE HYDROLASE from Neisseria meningitidis (serogroup A) (312 aa), FASTA scores: opt: 192, E(): 0.00016, (45.2% identity in 73 aa overlap); Q9RK95|SCF1.09 PUTATIVE HYDROLASE from Streptomyces coelicolor (258 aa), FASTA scores: opt: 188, E(): 0.00024, (30.1% identity in 226 aa overlap); Q9KZC3|SC6F7.19c PUTATIVE LIPASE from Streptomyces coelicolor (269 aa), FASTA scores: opt: 179, E(): 0.00086, (36.35% identity in 121 aa overlap); etc. Equivalent to AAK47641 Hydrolase, alpha/beta hydrolase family from Mycobacterium tuberculosis strain CDC1551 (261 aa) but shorter 37 aa. Contains serine active site signature of lipases (PS00120).; lipase LipV	3580638..3581312	Mycobacterium tuberculosis H37Rv	888133
NP_217720.1	CDS	Rv3204	NC_000962.2	3581315	3581620	D	Rv3204, (MTCY07D11.22c), len: 101 aa. Possible DNA methyltransferase (EC 2.1.1.-), similar to many hypothetical bacteriel proteins and methyltransferases e.g. Q9KT40|VC1065 METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE-RELATED PROTEIN from Vibrio cholerae (100 aa), FASTA scores: opt: 170, E(): 2.8e-05, (34.35% identity in 99 aa overlap); Q9UTN9|SPAC1250.04c PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (108 aa), FASTA scores: opt: 161, E(): 0.00013, (36.65% identity in 101 aa overlap); Q9YDF4|APE0959 175 AA LONG HYPOTHETICAL METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE from Aeropyrum pernix (175 aa), FASTA scores: opt: 144, E(): 0.003, (37.95% identity in 87 aa overlap); Q50855 PUTATIVE METHYLGUANINE-DNA METHYLTRANSFERASE from Myxococcus xanthus (147 aa), FASTA scores: opt: 141, E(): 0.0041, (37.65% identity in 93 aa overlap); etc.; DNA-methyltransferase (modification methylase)	3581315..3581620	Mycobacterium tuberculosis H37Rv	888132
NP_217721.1	CDS	Rv3205c	NC_000962.2	3581627	3582505	R	Rv3205c, (MTCY07D11.21), len: 292 aa. Hypothetical protein, highly similar to Q9CCG7|ML0818 HYPOTHETICAL PROTEIN from Mycobacterium leprae (297 aa), FASTA scores: opt: 1745, E(): 9.1e-98, (87.3% identity in 291 aa overlap).; hypothetical protein	complement(3581627..3582505)	Mycobacterium tuberculosis H37Rv	888877
YP_177942.1	CDS	moeB1	NC_000962.2	3582532	3583710	R	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ	complement(3582532..3583710)	Mycobacterium tuberculosis H37Rv	888871
NP_217723.1	CDS	Rv3207c	NC_000962.2	3583801	3584658	R	Rv3207c, (MTCY07D11.19), len: 285 aa. Hypothetical protein, highly similar but shorter (57 aa) to Q9CCG9|ML0816 HYPOTHETICAL PROTEIN from Mycobacterium leprae (341 aa), FASTA scores: opt: 1676, E(): 9.7e-96, (81.0% identity in 284 aa overlap). Also similar to C-terminus of Q9FBI6|SCP8.36 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (559 aa), FASTA scores: opt: 426, E(): 8.4e-19, (37.35% identity in 281 aa overlap); and similar to other hypothetical proteins (generally membrane proteins) e.g. Q9K456|SC2H12.28C PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (314 aa), FASTA scores: opt: 341, E(): 8.8e-14, (29.75% identity in 296 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142).; hypothetical protein	complement(3583801..3584658)	Mycobacterium tuberculosis H37Rv	888874
NP_217724.1	CDS	Rv3208	NC_000962.2	3585004	3585690	D	Rv3208, (MTCY07D11.18c), len: 228 aa. Probable transcriptional regulator, tetR family, equivalent to Q9CCH0|ML0815 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (228 aa), FASTA scores: opt: 1248, E(): 1.4e-74, (82.4% identity in 227 aa overlap). Also highly similar to Q9FBI8|SCP8.33c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (213 aa), FASTA scores: opt: 629, E(): 4e-34, (45.8% identity in 203 aa overlap); Q9KIL9|F58R F58R (FRAGMENT) from Streptomyces coelicolor A3(2) (149 aa), FASTA scores: opt: 497, E(): 1.3e-25, (50.35% identity in 147 aa overlap); Q9K3T5|SCE66.08 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (225 aa), FASTA scores: opt: 344, E(): 1.8e-15, (31.15% identity in 212 aa overlap); Q9RYK4|DRA0308 TRANSCRIPTIONAL REGULATOR, TETR FAMILY from Deinococcus radiodurans (239 aa), FASTA scores: opt: 290, E(): 6.5e-12, (30.5% identity in 223 aa overlap); etc. And also similar to Mycobacterium tuberculosis proteins P96381|Rv1019|MTCY10G2.30c HYPOTHETICAL 21.7 KDA PROTEIN (197 aa), FASTA scores: opt: 356, E(): 2.7e-16, (34.4% identity in 189 aa overlap); MTV034_4; MTY07A7A_3; MTV032_1; MTCY07A7_12; etc. Contains probable helix-turn-helix motif at aa 60-81 (Score 1517, +4.35 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.; TetR family transcriptional regulator	3585004..3585690	Mycobacterium tuberculosis H37Rv	887905
YP_177943.1	CDS	TB9.4	NC_000962.2	3585677	3585949	R	Rv3208A, len: 90 aa. TB9.4, conserved hypothetical protein (see citations below), equivalent to Q9CCH1|ML0814 HYPOTHETICAL PROTEIN from Mycobacterium leprae (82 aa), FASTA scores: opt: 411, E(): 1.8e-22, (81.0% identity in 79 aa overlap). Also similar, but shorter in N-terminus, to Q9FBI9|SCP8.32c PUTATIVE ATP-BINDING PROTEIN from Streptomyces coelicolor (94 aa), FASTA scores: opt: 246, E(): 8.1e-11, (53.4% identity in 73 aa overlap); Q9DGP6 (alias Q9DGP4) GLUTAMATE DECARBOXYLASE 67 KDA ISOFORM (FRAGMENT) from Alepocephalus bairdii (182 aa), FASTA scores: opt: 100, E(): 2.6, (35.3% identity in 85 aa overlap). Corresponds to Statens Serum Institute antigen, CYP10 TB9.4. Has N-terminal sequence, VEVKIGITDSPRELV.; hypothetical protein	complement(3585677..3585949)	Mycobacterium tuberculosis H37Rv	3205107
NP_217725.1	CDS	Rv3209	NC_000962.2	3586274	3586834	D	Rv3209, (MTCY07D11.17c), len: 186 aa. Conserved hypothetical thr-, pro-rich protein, equivalent (but shorter 36 aa in N-terminus) to Q9CCH2|ML0813 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (195 aa), FASTA scores: opt: 508, E(): 1.4e-15, (58.4% identity in 185 aa overlap). Also some similarity with Q10390|MMS3_MYCTU|MMPS3|Rv2198c|MT2254|MTCY190.09c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from M. tuberculosis (299 aa), FASTA scores: opt: 339, E(): 3.7e-08, (35.0% identity in 180 aa overlap); and Q9CCE9|MMPS3|ML0877 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (293 aa), FASTA scores: opt: 272, E(): 2.8e-05, (36.4% identity in 173 aa overlap).; hypothetical protein	3586274..3586834	Mycobacterium tuberculosis H37Rv	888875
NP_217726.1	CDS	Rv3210c	NC_000962.2	3586844	3587539	R	Rv3210c, (MTCY07D11.16), len: 231 aa. Conserved hypothetical protein, similar (but N-terminus shorter) to Q9FBJ1|SCP8.30 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (260 aa), FASTA scores: opt: 599, E(): 1.1e-30, (42.5% identity in 233 aa overlap); and some similarity to Q9RRV1|DR2384 PHENYLACETIC ACID DEGRADATION PROTEIN PAAC from Deinococcus radiodurans (263 aa), FASTA scores: opt: 129, E(): 0.43, (27.9% identity in 172 aa overlap); and Q9F621 FLGK PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (472 aa).; hypothetical protein	complement(3586844..3587539)	Mycobacterium tuberculosis H37Rv	888876
NP_217727.1	CDS	rhlE	NC_000962.2	3587798	3589381	D	Rv3211, (MTCY07D11.15c), len: 527 aa. Probable rhlE, ATP-dependent RNA helicase, equivalent (but shorter 22 aa) to Q9CCH3|RHLE|ML0811 PUTATIVE ATP-DEPENDENT RNA HELICASE from Mycobacterium leprae (544 aa), FASTA scores: opt: 2497, E(): 8.7e-131, (74.75% identity in 531 aa overlap). Also highly similar to other RNA helicases e.g. Q9FBJ2|SCP8.29c from Streptomyces coelicolor (879 aa), FASTA scores: opt: 1458, E(): 3.6e-73, (52.5% identity in 522 aa overlap); Q9DF36 from Xenopus laevis (African clawed frog) (800 aa), FASTA scores: opt: 792, E(): 2.3e-36, (37.15% identity in 385 aa overlap); Q99Z38|DEAD|SPY1415 from Streptococcus pyogenes (759 aa), FASTA scores: opt: 779, E(): 1.1e-35, (37.1% identity in 380 aa overlap); P33906|DEAD|CSDA from Klebsiella pneumoniae (642 aa), FASTA scores: opt: 768, E(): 4e-35, (43.4% identity in 387 aa overlap); etc. Contains ATP/GTP-binding site motif A (PS00017) and DEAD-box subfamily ATP-dependent helicases signature (PS00039). SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY AND SIMILAR TO HELICASE C-TERMINAL DOMAIN.; ATP-dependent RNA helicase RhlE	3587798..3589381	Mycobacterium tuberculosis H37Rv	888840
NP_217728.1	CDS	Rv3212	NC_000962.2	3589394	3590617	D	Rv3212, (MTCY07D11.14c), len: 407 aa. Hypothetical ala-, val-rich protein, equivalent to Q9CCH4|ML0810 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (407 aa), FASTA scores: opt: 2158, E(): 5.3e-119, (79.85% identity in 407 aa overlap). Weak similarity to several eukaryotic transcription factors e.g. P08393|ICP0_HSV11|ICP0|IE110 TRANS-ACTING TRANSCRIPTIONAL PROTEIN from Herpes simplex virus (type 1 / strain 17) (775 aa), FASTA scores: opt: 115, E(): 2, (26.9% identity in 334 aa overlap).; hypothetical protein	3589394..3590617	Mycobacterium tuberculosis H37Rv	887931
NP_217729.1	CDS	Rv3213c	NC_000962.2	3590692	3591492	R	Rv3213c, (MTCY07D11.13), len: 266 aa. Possible soj/parA-related protein, very similar in particular to Soj/ParA proteins (and relatives) from Bacillus subtilis that inhibit the initiation of sporulation by preventing phosphorylation of Spo0A (see Quisel & Grossman 2000) e.g. Q9S228|SCI51.12c from Streptomyces coelicolor (340 aa), FASTA scores: opt: 746, E(): 1.6e-40, (48.2% identity in 249 aa overlap); Q9HT11|SOJ|PA5563 from Pseudomonas aeruginosa (262 aa), FASTA scores: opt: 649, E(): 2.1e-34, (42.2% identity in 256 aa overlap); Q9PB62|XF2282 from Xylella fastidiosa (264 aa), FASTA scores: opt: 624, E(): 8.3e-33, (42.25% identity in 251 aa overlap); Q9K5N0|SOJ_BACHD|SOJ|BH4058 from Bacillus halodurans (253 aa), FASTA scores: opt: 621, E(): 1.2e-32, (41.55% identity in 248 aa overlap); P37522|SOJ_BACSU (253 aa), FASTA scores: opt: 620, E(): 1.4e-32, (41.65% identity in 245; etc. Also similar to various mycobacterial proteins: U00021_10 from Mycobacterium leprae, MTCI125_29 from Mycobacterium tuberculosis, MLCB1351_6 from Mycobacterium leprae, MTV028_9c|Rv3918c|PARA PROBABLE CHROMOSOME PARTITIONING PROTEIN from Mycobacterium tuberculosis, MSGDNAB_18 from Mycobacterium leprae. SEEMS TO BELONG TO THE PARA FAMILY.; SOJ/PARA-like protein	complement(3590692..3591492)	Mycobacterium tuberculosis H37Rv	888896
YP_177944.1	CDS	gpm2	NC_000962.2	3591646	3592257	D	forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily; acid phosphatase	3591646..3592257	Mycobacterium tuberculosis H37Rv	888830
NP_217731.1	CDS	entC	NC_000962.2	3592254	3593372	D	synthesizes isochorismate acid from chorismate; isochorismate synthase	3592254..3593372	Mycobacterium tuberculosis H37Rv	888824
NP_217732.1	CDS	Rv3216	NC_000962.2	3593520	3593852	D	Rv3216, (MTCY07D11.10c), len: 110 aa. Possible acetyltransferase (2.3.1.-), similar but shorter to many e.g. Q9AB32|CC0402 ACETYLTRANSFERASE (GNAT FAMILY) from Caulobacter crescentus (159 aa), FASTA scores: opt: 325, E(): 3.8e-17, (45.65% identity in 103 aa overlap); P79081|ATS1 PUTATIVE ACETYLTRANSFERASE ATS1 from Schizosaccharomyces pombe (Fission yeast) (168 aa), FASTA scores: opt: 313, E(): 3.1e-16, (47.6% identity in 105 aa overlap); Q9I640|PA0478 PROBABLE N-ACETYLTRANSFERASE from Pseudomonas aeruginosa (158 aa), FASTA scores: opt: 308, E(): 6.9e-16, (50.0% identity in 98 aa overlap); Q9KHE3 PUTATIVE ACETYLTRANSFERASE from Anabaena sp. strain PCC 7120 (164 aa), FASTA scores: opt: 269, E(): 5.4e-13, (41.75% identity in 103 aa overlap); etc. Also some similarity to diamine acetyltransferases (EC 2.3.1.57) e.g. Q28999|ATDA_PIG|SAT from Sus scrofa (Pig) (171 aa), FASTA scores: opt: 152, E(): 0.00025, (23.15% identity in 108 aa overlap).; acetyltransferase	3593520..3593852	Mycobacterium tuberculosis H37Rv	888845
NP_217733.1	CDS	Rv3217c	NC_000962.2	3593804	3594235	R	Rv3217c, (MTCY07D11.09), len: 143 aa. Probable conserved integral membrane protein, equivalent (highly similar but shorter 30 aa) to Q9CCH6|ML0806 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (173 aa). Also similar to others e.g. Q9F3L9|2SC7G11.04 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (152 aa), FASTA scores: opt: 177, E(): 0.00024, (33.8% identity in 136 aa overlap). And shows similarity to O34238|MVIN|VC0680 VIRULENCE FACTOR MVIN HOMOLOG from Vibrio (525 aa), FASTA scores: opt: 126, E(): 0.97, (30.9% identity in 68 aa overlap). First GTG taken.; integral membrane protein	complement(3593804..3594235)	Mycobacterium tuberculosis H37Rv	888843
NP_217734.1	CDS	Rv3218	NC_000962.2	3594468	3595433	D	Rv3218, (MTCY07D11.08c), len: 321 aa. Conserved hypothetical protein, similar to several hypothetical bacterial proteins e.g. Q9F3M0|2SC7G11.03c from Streptomyces coelicolor (322 aa), FASTA scores: opt: 694, E(): 4.2e-35, (39.95% identity in 328 aa overlap); Q9A0J4|SPY0752 from Streptomyces pyogenes (340 aa), FASTA scores: opt: 187, E(): 0.00033, (30.5% identity in 141 aa overlap); O31502|YERQ from Bacillus subtilis (303 aa), FASTA scores: opt: 184, E(): 0.00045, (34.15% identity in 126 aa overlap); etc.; hypothetical protein	3594468..3595433	Mycobacterium tuberculosis H37Rv	888906
NP_217735.1	CDS	whiB1	NC_000962.2	3595713	3595967	D	Rv3219, (MTCY07D11.07c), len: 84 aa. Probable whiB1 (alternate gene name: whmE), WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor. Equivalent to Q9CCH7|WHIB1|ML0804 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (84 aa), FASTA scores: opt: 580, E(): 3.5e-35, (95.25% identity in 84 aa overlap). Highly similar to several e.g. Q9X952|WBLE DEVELOPMENTAL REGULATORY PROTEIN WHIB-PARALOG from Streptomyces coelicolor (85 aa), FASTA scores: opt: 477, E(): 9.2e-28, (75.3% identity in 81 aa overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa), FASTA scores: opt: 383, E(): 6.1e-21, (60.75% identity in 79 aa overlap); Q9K4K8|SC5F8.16c from Streptomyces coelicolor (83 aa), FASTA scores: opt: 346, E(): 2.5e-18, (54.75% identity in 84 aa overlap); etc.; whmE; transcriptional regulatory protein WHIB-like WHIB1	3595713..3595967	Mycobacterium tuberculosis H37Rv	887980
NP_217736.1	CDS	Rv3220c	NC_000962.2	3596029	3597534	R	Rv3220c, (MTCY07D11.06), len: 501 aa. Probable sensor (probably histidine kinase), equivalent to Q9CCH8|ML0803 PUTATIVE TWO-COMPONENT SYSTEM SENSOR KINASE from Mycobacterium leprae (500 aa). Similar to others e.g. Q9F3M1|2SC7G11.01 PUTATIVE HISTIDINE KINASE (FRAGMENT) from Streptomyces coelicolor (372 aa), FASTA scores: opt: 1038, E(): 7.4e-56, (48.95% identity in 380 aa overlap); Q9A3K5|CC3198 SENSOR HISTIDINE KINASE from Caulobacter crescentus (327 aa), FASTA scores: opt: 311, E(): 1.2e-11, (33.35% identity in 201 aa overlap) (similarity only in C-terminal part for this one); Q9A2T2|CC3474 PUTATIVE SENSOR HISTIDINE KINASE from Caulobacter crescentus (547 aa); etc. C-terminal half shows similarity to many sensor proteins, that respond to various stimuli from Methanobacterium thermoautotrophicum e.g. O26568|MTH468 SENSORY TRANSDUCTION HISTIDINE KINASE (554 aa), FASTA scores: opt: 425, E(): 2.1e-18, (34.0% identity in 244 aa overlap); O26546|MTH446 SENSORY TRANSDUCTION REGULATORY PROTEIN (583 aa), FASTA scores: opt: 380, E(): 1.2e-15, (37.15% identity in 202 aa overlap); O26913|MTH823 SENSORY TRANSDUCTION REGULATORY PROTEIN (677 aa), FASTA scores: opt: 375, E(): 2.7e-15, (35.4% identity in 195 aa overlap); etc. SEEMS SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES.; two component sensor kinase	complement(3596029..3597534)	Mycobacterium tuberculosis H37Rv	888801
NP_217737.1	CDS	TB7.3	NC_000962.2	3597551	3597766	R	Rv3221c, (MTCY07D11.05), len: 71 aa. TB7.3, Biotinylated protein (see citations below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE BIOTINYLATED PROTEIN TB7.3 HOMOLOG from Mycobacterium leprae (70 aa), FASTA scores: opt: 367, E(): 4e-18, (90.0% identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM BIOTINYLATED PROTEIN TB7.3 HOMOLOG from Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341, E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G BIOTIN CARBOXYLASE from Halobacterium sp. strain NRC-1 (610 aa), FASTA scores: opt: 212, E(): 4e-07, (50.0% identity in 68 aa overlap); Q58628|PYCB_METJA|MJ1231 PYRUVATE CARBOXYLASE SUBUNIT B from Methanococcus jannaschii (567 aa), FASTA scores: opt: 192, E(): 7.8e-06, (44.8% identity in 58 aa overlap); Q9ZAA7|GCDC GLUTACONYL-CoA DECARBOXYLASE GAMMA SUBUNIT from Acidaminococcus fermentans (145 aa), FASTA scores: opt: 184, E(): 8.9e-06, (39.4% identity in 66 aa overlap); etc.; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit	complement(3597551..3597766)	Mycobacterium tuberculosis H37Rv	888096
YP_177945.1	CDS	Rv3221A	NC_000962.2	3598051	3598356	R	Rv3221A, len: 101 aa. Possible anti-sigma factor, similar to Q9XCD7|AAD41811.1 unknown protein from Mycobacterium smegmatis, linked to sigma factor sigH (see Fernandes et al., 1999) (101 aa), FASTA scores: opt: 422, E(): 3.4e-22, (64.9% identity in 94 aa overlap); and to Q9RL96|RsrA anti-sigma factor from Streptomyces coelicolor (see Kang et al., 1999) (105 aa), FASTA scores: opt: 163, E(): 0.00016, (32.05% identity in 78 aa overlap).; anti-sigma factor	complement(3598051..3598356)	Mycobacterium tuberculosis H37Rv	3205091
NP_217738.1	CDS	Rv3222c	NC_000962.2	3598353	3598904	R	Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 GLYCINE-RICH PROTEIN LIKE from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6, (36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% identity in 170 aa overlap); AAK45760|MT1497.1 PE_PGRS FAMILY PROTEIN from strain CDC1551 (1408 aa), FASTA scores: opt: 137, E(): 2, (31.75% identity in 148 aa overlap); etc.; hypothetical protein	complement(3598353..3598904)	Mycobacterium tuberculosis H37Rv	887655
NP_217739.1	CDS	sigH	NC_000962.2	3598901	3599551	R	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE	complement(3598901..3599551)	Mycobacterium tuberculosis H37Rv	888094
NP_217740.1	CDS	Rv3224	NC_000962.2	3599851	3600699	D	Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to BAB49551|MLL2413 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, E(): 6.4e-59, (57.95% identity in 276 aa overlap); Q9AB34|CC0400 SHORT CHAIN DEHYDROGENASE FAMILY PROTEIN from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59, (55.9% identity in 281 aa overlap); and Q9VB10|CG5590 HYPOTHETICAL PROTEIN (SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Drosophila melanogaster (Fruit fly) (412 aa), FASTA scores: opt: 966, E(): 2.5e-53, (52.15% identity in 278 aa overlap). Similar to various proteins (principaly oxidoreductases) e.g. Q18639|C45B11.3 HYPOTHETICAL PROTEIN (SIMILAR TO THE SDR FAMILY) from Caenorhabditis elegans (293 aa), FASTA scores: opt: 921, E(): 1.2e-50, (51.3% identity in 271 aa overlap); Q9HZV5|PA2892 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (274 aa), FASTA scores: opt: 847, E(): 5.1e-46, (49.25% identity in 274 aa overlap); Q9I6V0|PA0182 PROBABLE SHORT-CHAIN DEHYDROGENASE (SIMILAR TO THE SDR FAMILY) from Pseudomonas aeruginosa (250 aa), FASTA scores: opt: 333, E(): 8.3e-14, (29.8% identity in 245 aa overlap); Q9HY98|PA3511 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (253 aa), FASTA scores: opt: 330, E(): 1.3e-13, (31.2% identity in 250 aa overlap); etc. Related proteins in Mycobacterium tuberculosis include MTCY02B10.14, MTCY369.14, and MTCY09F9.36. Has ATP/GTP-binding site motif A, (PS00017) near C-terminus. MAY BE BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short chain dehydrogenase	3599851..3600699	Mycobacterium tuberculosis H37Rv	888852
YP_177946.1	CDS	Rv3224A	NC_000962.2	3600635	3600823	D	Rv3224A, len: 62 aa. Conserved hypothetical protein (possibly gene fragment), overlaps Rv3224. Similar to N-terminus of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 104, E(): 0.78, (59.37% identity in 32 aa overlap). Note that upstream ORF Rv3224B is similar to C-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis.; hypothetical protein	3600635..3600823	Mycobacterium tuberculosis H37Rv	3205092
YP_177947.1	CDS	Rv3224B	NC_000962.2	3600801	3601019	D	Rv3224B, len: 72 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis.; hypothetical protein	3600801..3601019	Mycobacterium tuberculosis H37Rv	3205093
NP_217742.1	CDS	Rv3225c	NC_000962.2	3601016	3602440	R	Rv3225c, (MTCY07D11.01), len: 474 aa (start uncertain). Possible transferase (EC 2.-.-.-). C-terminal part shows some similarity to various bacterial proteins e.g. BAB49093|MLL1809 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (298 aa), FASTA scores: opt: 557, E(): 2.8e-26, (34.55% identity in 295 aa overlap); P14509|KKA8_ECOLI|APHA AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Escherichia coli (271 aa), FASTA scores: opt: 194, E(): 0.00018, (27.75% identity in 227 aa overlap); Q53826|CPH CAPREOMYCIN PHOSPHOTRANSFERASE from Streptomyces capreolus (281 aa), FASTA scores: opt: 178, E(): 0.0017, (30.5% identity in 269 aa overlap); Q9CDM4|YWIA UNKNOWN PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (213 aa), FASTA scores: opt: 167, E(): 0.0061, (2705% identity in 149 aa overlap); Q9X843|SC9B1.24 PUTATIVE TRANSFERASE (FRAGMENT) from Streptomyces coelicolor (317 aa), FASTA scores: opt: 165, E(): 0.011, (26.05% identity in 280 aa overlap); etc.; transferase	complement(3601016..3602440)	Mycobacterium tuberculosis H37Rv	888804
NP_217743.1	CDS	Rv3226c	NC_000962.2	3602564	3603322	R	Rv3226c, (MTCY20B11.01c), len: 252 aa. Conserved hypothetical protein, similar to various hypothetical bacterial proteins e.g. Q9CCI2|ML0793 PUTATIVE BACTERIOPHAGE PROTEIN from Mycobacterium leprae (252 aa), FASTA scores: opt: 1183, E(): 3.8e-68, (70.65% identity in 252 aa overlap); BAB54183|MLR7795 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (369 aa), FASTA scores: opt: 417, E(): 2.9e-19, (33.75% identity in 252 aa overlap); O64131 YOQW PROTEIN from Bacteriophage SPBc2 (224 aa), FASTA scores: opt: 413, E(): 3.4e-19, (38.5% identity in 244 aa overlap); O31916 YOQW PROTEIN from Bacillus subtilis (224 aa), FASTA scores: opt: 413, E(): 3.4e-19, (38.5% identity in 244 aa overlap); O34906 YOAM PROTEIN from Bacillus subtilis (227 aa), FASTA scores: opt: 401, E(): 2e-18, (37.7% identity in 244 aa overlap); Q9K4A5|SC7E4.11 HYPOTHETICAL 30.8 KDA PROTEIN from Streptomyces coelicolor (271 aa), FASTA scores: opt: 383, E(): 3.3e-17, (39.6% identity in 283 aa overlap); etc.; hypothetical protein	complement(3602564..3603322)	Mycobacterium tuberculosis H37Rv	888220
NP_217744.1	CDS	aroA	NC_000962.2	3603377	3604729	D	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase	3603377..3604729	Mycobacterium tuberculosis H37Rv	888753
NP_217745.1	CDS	Rv3228	NC_000962.2	3604726	3605718	D	Rv3228, (MTCY20B11.03), len: 330 aa. Conserved hypothetical protein, equivalent to Q9CCI4|ML0791 HYPOTHETICAL PROTEIN from Mycobacterium leprae (327 aa), FASTA scores: opt: 1828, E(): 1e-98, (84.0% identity in 331 aa overlap). Also similar to several hypothetical bacterial proteins e.g. Q9K4A8|SC7E4.08c from Streptomyces coelicolor (337 aa), FASTA scores: opt: 1051, E(): 1e-53, (52.65% identity in 338 aa overlap); Q9HUL3|PA4952 from Pseudomonas aeruginosa (339 aa), FASTA scores: opt: 392 ,E(): 1.4e-15, (34.85% identity in 281 aa overlap); Q9PFV1|XF0556 from Xylella fastidiosa (341 aa), FASTA scores: opt: 367, E(): 4e-14, (36.85% identity in 247 aa overlap); P45339|YJEQ_HAEIN|HI1714 from Haemophilus influenzae (346 aa), FASTA scores: opt: 355, E(): 2e-13, (31.65% identity in 281 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A.; hypothetical protein	3604726..3605718	Mycobacterium tuberculosis H37Rv	888785
YP_177948.1	CDS	Rv3229c	NC_000962.2	3605751	3607034	R	Rv3229c, (MTCY20B11.04c), len: 427 aa. Possible linoleoyl-CoA desaturase (EC 1.14.99.25), showing similarity with desaturases and other proteins e.g. Q08871|DES6|SLL0262 LINOLEOYL-CoA DESATURASE from Synechocystis sp. strain PCC 6803 (359 aa), FASTA scores: opt: 319, E(): 4e-13, (25.1% identity in 295 aa overlap); Q54795|DESD DELTA 6 DESATURASE from Spirulina platensis (368 aa), FASTA scores: opt: 268, E(): 7.7e-10, (25.0% identity in 300 aa overlap); Q9ZTU8|S276 PROTEIN WITH SIMILARITY TO CYTOCHROME B5 DOMAIN from Triticum aestivum (Wheat) (469 aa), FASTA scores: opt: 240, E(): 5.9e-08, (27.05% identity in 266 aa overlap); etc. Note that previously known as desA3.; desA3; linoleoyl-CoA desaturase	complement(3605751..3607034)	Mycobacterium tuberculosis H37Rv	888821
NP_217747.1	CDS	Rv3230c	NC_000962.2	3607112	3608254	R	Rv3230c, (MTCY20B11.05c), len: 380 aa. Putative oxidoreductase (EC 1.-.-.-), with some similarity to various proteins, especially reductases e.g. Q9HUS4|PA4889 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (366 aa), FASTA scores: opt: 516, E(): 1.8e-24, (33.8% identity in 367 aa overlap); P95533|TDNB ELECTRON TRANSFER PROTEIN from Pseudomonas putida (337 aa), FASTA scores: opt: 380, E(): 4e-16, (30.7% identity in 277 aa overlap); BAB34381|ECS0958 NADH OXIDOREDUCTASE FOR THE HCP from Escherichia coli strain O157:H7 (322 aa), FASTA scores: opt: 369, E(): 1.8e-15, (28.65% identity in 328 aa overlap); Q44253|ATDA5 ANILINE DIOXYGENASE REDUCTASE COMPONENT from Acinetobacter sp. (336 aa), FASTA scores: opt: 305, E(): 1.6e-11, (27.4% identity in 303 aa overlap); etc.; oxidoreductase	complement(3607112..3608254)	Mycobacterium tuberculosis H37Rv	888748
NP_217748.1	CDS	Rv3231c	NC_000962.2	3608364	3608873	R	Rv3231c, (MTCY20B11.06c), len: 169 aa. Hypothetical protein, similar to Q9KYX9|SCE33.03c HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa overlap).; hypothetical protein	complement(3608364..3608873)	Mycobacterium tuberculosis H37Rv	888749
NP_217749.1	CDS	pvdS	NC_000962.2	3608870	3609757	R	Rv3232c, (MTCY20B11.07c), len: 295 aa (start uncertain). Possible pvdS, an alternative RNA polymerase sigma factor, highly similar (but N-terminus longer 25-50 residues approximatively) to Q9RIZ9|SCJ1.15 PUTATIVE REGULATOR from Streptomyces coelicolor (267 aa), FASTA scores: opt: 1189, E(): 1.4e-70, (65.65% identity in 262 aa overlap); Q9KU02|VC0728 HYPOTHETICAL PROTEIN from Vibrio cholerae (258 aa), FASTA scores: opt: 1074, E(): 4.5e-63, (62.6% identity in 254 aa overlap); P72119|PVDS PAO SUBSTRAIN OT684 PYOVERDINE GENE TRANSCRIPTIONAL REGULATOR PVDS (FRAGMENT) from Pseudomonas aeruginosa (see citations below) (237 aa), FASTA scores: opt: 988, E(): 1.8e-57, (60.8% identity in 227 aa overlap). Also highly similar to Q9I154|PA2428 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (304 aa), FASTA scores: opt: 1057, E(): 6.8e-62, (60.7% identity in 252 aa overlap); Q9I6Z1|PA0141 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 990, E(): 1.6e-57, (54.6% identity in 249 aa overlap); and other hypothetical bacterial proteins. Could be a member of a subfamily of RNA polymerase sigma factors which direct the synthesis of extracellular products by bacteria.; transcriptional regulatory protein PvdS	complement(3608870..3609757)	Mycobacterium tuberculosis H37Rv	888760
NP_217750.1	CDS	Rv3233c	NC_000962.2	3609781	3610371	R	Rv3233c, (MTCY20B11.08c), len: 196 aa. Hypothetical protein, similar to C-terminus of Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 308, E(): 1.2e-12, (32.0% identity in 200 aa overlap); and several hypothetical M. tuberculosis proteins e.g. O06343|YY80_MYCTU|Rv3480c|MTCY13E12.33c (497 aa), FASTA scores: opt: 248, E(): 9.8e-09, (27.5% identity in 200 aa overlap); MTCY28_26; MTCY493_29; MTCY31_25; MTCY31_25.; hypothetical protein	complement(3609781..3610371)	Mycobacterium tuberculosis H37Rv	888773
NP_217751.1	CDS	Rv3234c	NC_000962.2	3610374	3611189	R	Rv3234c, (MTCY20B11.09c), len: 271 aa. Hypothetical protein, similar to C-terminus of Mycobacterium tuberculosis hypothetical proteins e.g. P71694|Rv1425|MTCY21B4.43|MTCY493.29c (459 aa), FASTA scores: opt: 498, E(): 5.2e-24, (36.8% identity in 261 aa overlap); MTCY03A2.28; MTCY31.23; MTCY493_29; MTCY28_26; MTV013_8; MTY13E12_33; etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 309, E(): 4.3e-12, (33.35% identity in 189 aa overlap).; hypothetical protein	complement(3610374..3611189)	Mycobacterium tuberculosis H37Rv	888767
NP_217752.1	CDS	Rv3235	NC_000962.2	3611300	3611941	D	Rv3235, (MTCY20B11.10), len: 213 aa. Hypothetical unknown ala-, arg-, pro-rich protein.; hypothetical protein	3611300..3611941	Mycobacterium tuberculosis H37Rv	888862
YP_177949.1	CDS	Rv3236c	NC_000962.2	3611959	3613116	R	Rv3236c, (MTCY20B11.11c), len: 385 aa. Probable conserved integral membrane transport protein, possibly cation (Na/H) transporter, equivalent to Q9CCI5|ML0782 putative transmembrane transport protein from Mycobacterium leprae (385 aa), FASTA scores: opt: 1975, E(): 2.4e-108, (81.55% identity in 385 aa overlap). Highly similar to others e.g. O69958|SC4H2.03c putative transmembrane transport protein from Streptomyces coelicolor (411 aa), FASTA scores: opt: 1226, E(): 1.6e-64, (53.5% identity in 372 aa overlap); Q9XAKO|SC66T3.13c putative transmembrane transport protein from Streptomyces coelicolor (403 aa), FASTA scores: opt: 1198, E(): 6.8e-63, (53.25% identity in 370 aa overlap); Q9RV80|DR1149 putative Na+/H+ antiporter from Deinococcus radiodurans (383 aa), FASTA scores: opt: 1069, E(): 2.3e-55, (47.35% identity in 376 aa overlap); Q9L191|SC10G8.11 putative transmembrane transport protein from Streptomyces coelicolor (446 aa), FASTA scores: opt: 695, E(): 1.9e-33, (38.05% identity in 384 aa overlap); Q9RRW8|DR2367 putative glutathione-regulated potassium-efflux system protein KEFB from Deinococcus radiodurans (575 aa), FASTA scores: opt: 414, E(): 6.2e-17, (30.25% identity in 380 aa overlap); etc. SEEMS TO BELONG TO THE CPA2 FAMILY. Note that previously known as kefB.; kefB; integral membrane transport protein	complement(3611959..3613116)	Mycobacterium tuberculosis H37Rv	888861
NP_217754.1	CDS	Rv3237c	NC_000962.2	3613121	3613603	R	Rv3237c, (MTCY20B11.12c), len: 160 aa. Conserved hypothetical protein, equivalent to Q9CCI6|ML0781 HYPOTHETICAL PROTEIN from Mycobacterium leprae (160 aa), FASTA scores: opt: 828, E(): 1.5e-45, (80.6% identity in 160 aa overlap); and similar to other hypothetical bacterial proteins and more weakly to putative potassium channels e.g. Q9RV81|DR1148 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (175 aa), FASTA scores: opt: 420, E(): 9.5e-20, (37.95% identity in 158 aa overlap); O69959|SC4H2.04c HYPOTHETICAL 17.1 KDA PROTEIN from Streptomyces coelicolor (161 aa), FASTA scores: opt: 315, E(): 3.8e-13, (40.0% identity in 150 aa overlap); Q9HNH3|PCHB|VNG2104G POTASSIUM CHANNEL HOMOLOG from Halobacterium sp. strain NRC-1 (418 aa), FASTA scores: opt: 158, E(): 0.007, (31.45% identity in 124 aa overlap); Q58752|YD57_METJA|MJ1357 PUTATIVE POTASSIUM CHANNEL PROTEIN from Methanococcus jannaschii (343 aa), FASTA scores: opt: 143, E(): 0.053, (33.8% identity in 68 aa overlap).; hypothetical protein	complement(3613121..3613603)	Mycobacterium tuberculosis H37Rv	888803
NP_217755.1	CDS	Rv3238c	NC_000962.2	3613664	3614398	R	Rv3238c, (MTCY20B11.13c), len: 244 aa. Probable conserved integral membrane protein, similar to several hypothetical proteins and transmembrane proteins e.g. Q9UN92|NRM29 MULTISPANNING NUCLEAR ENVELOPE MEMBRANE PROTEIN NURIM (FRAGMENT) from Homo sapiens (Human) (261 aa), FASTA scores: opt: 281, E(): 3.3e-11, (30.7% identity in 189 aa overlap); Q9VEG9|CG7655 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (253 aa), FASTA scores: opt: 242, E(): 1.1e-08, (27.7% identity in 242 aa overlap); BAB48937|MLR1600 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (222 aa), FASTA scores: opt: 137, E(): 0.066, (28.1% identity in 185 aa overlap); BAB57936|SAV1774 AESENICAL PUMP MEMBRANE PROTEIN HOMOLOG from Staphylococcus aureus subsp. aureus Mu50 (430 aa), FASTA scores: opt: 125, E(): 0.68, (25.7% identity in 144 aa overlap); etc.; integral membrane protein	complement(3613664..3614398)	Mycobacterium tuberculosis H37Rv	888858
NP_217756.1	CDS	Rv3239c	NC_000962.2	3614457	3617603	R	Rv3239c, (MTCY20B11.14c), len: 1048 aa. Probable conserved transmembrane protein, organised in two domains. Domain comprising first 500 aa residues is similar to various antibiotic resistance and efflux proteins and contains sugar transport proteins signature 1 (PS00216); e.g. Q9RL22|SC5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 905, E(): 3.1e-41, (36.95% identity in 482 aa overlap); and O68912|FRNF PUTATIVE ANTIBIOTIC ANTIPORTER from Streptomyces roseofulvus (517 aa), FASTA scores: opt: 866, E(): 4.1e-39, (37.1% identity in 512 aa overlap). Second part, corresponding to last 550 aa residues, is very similar to Q50733|Rv2565|MTCY9C4.03c hypothetical 62.1 kDa protein from Mycobacterium tuberculosis (583 aa), FASTA scores: E(): 2.1e-28, (36.5% identity in 572 aa overlap). Also equivalent to Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN MEMBRANE PROTEIN (SIMILAR TO SUGAR TRANSPORTER FAMILY) from Mycobacterium tuberculosis (1065 aa), FASTA scores: opt: 4328, E(): 0, (64.15% identity in 1046 aa overlap); and similar to other Mycobacterium tuberculosis proteins: MTCY3G12.01, E(): 6.3e-32; MTCY98.02c, E(): 6.3e-32; MTCY9C4.03c, E(): 1.5e-26; MTCY369.27c, E(): 2.5e-26. Equivalent to AAK47679 Drug transporter from Mycobacterium tuberculosis strain CDC1551 (1065 aa) but shorter 20 aa. Contains cyclic nucleotide-binding domain signature 2 (PS00889). Probably member of major facilitator superfamily (MFS).; transmembrane transport protein	complement(3614457..3617603)	Mycobacterium tuberculosis H37Rv	888856
YP_177950.1	CDS	secA1	NC_000962.2	3617682	3620531	R	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA	complement(3617682..3620531)	Mycobacterium tuberculosis H37Rv	888860
NP_217758.1	CDS	Rv3241c	NC_000962.2	3620610	3621254	R	Rv3241c, (MTCY20B11.16c), len: 213 aa. Conserved hypothetical protein, similar to many hypothetical proteins and to some putative ribosomal proteins e.g. Q9CCI7|ML0778 HYPOTHETICAL PROTEIN from Mycobacterium leprae (229 aa), FASTA scores: opt: 1234, E(): 1.3e-72, (89.3% identity in 206 aa overlap); Q9KYX2|SCE33.11c HYPOTHETICAL 27.9 KDA PROTEIN from Streptomyces coelicolor (254 aa), FASTA scores: opt: 487, E(): 2.2e-24, (47.6% identity in 210 aa overlap); Q9FLV3 PROTEIN SIMILAR TO RIBOSOMAL PROTEIN 30S SUBUNIT from Arabidopsis thaliana (Mouse-ear cress) (365 aa), FASTA scores: opt: 264, E(): 7e-10, (26.4% identity in 212 aa overlap); P19954|RR30_SPIOL|RPS22 PLASTID-SPECIFIC 30S RIBOSOMAL PROTEIN 1, chloroplast, from Spinacia oleracea (Spinach) (302 aa), FASTA scores: opt: 261, E(): 9.3e-10, (26.15% identity in 214 aa overlap); P47995|YSEA_STACA HYPOTHETICAL PROTEIN IN SECA 5'REGION (ORF1) (FRAGMENT) (BELONGS TO THE S30AE FAMILY OF RIBOSOMAL PROTEINS) from Staphylococcus carnosus (165 aa), FASTA scores: opt: 201, E(): 4.2e-06, (33.35% identity in 147 aa overlap); etc.; hypothetical protein	complement(3620610..3621254)	Mycobacterium tuberculosis H37Rv	888849
NP_217759.1	CDS	Rv3242c	NC_000962.2	3621570	3622211	R	Rv3242c, (MTCY20B11.17c), len: 213 aa. Conserved hypothetical protein, highly similar in N-terminus to Q9CCI9|ML0776 HYPOTHETICAL PROTEIN from Mycobacterium leprae (85 aa), FASTA scores: opt: 324, E(): 1.7e-13, (78.1% identity in 64 aa overlap). Also similar to Q9RUJ7|DR1389 PUTATIVE COMPETENCE PROTEIN COMF from Deinococcus radiodurans (219 aa), FASTA scores: opt: 223, E(): 6.3e-07, (35.8% identity in 215 aa overlap); BAB50338|MLL3453 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (240 aa), FASTA scores: opt: 218, E(): 1.4e-06, (28.5% identity in 224 aa overlap); Q9A9Y1|CC0830 COMPETENCE PROTEIN F from Caulobacter crescentus (265 aa), FASTA scores: opt: 182, E(): 0.00026, (30.15% identity in 219 aa overlap); etc. Equivalent to AAK47682 from Mycobacterium tuberculosis strain CDC1551 (241 aa) but shorter 29 aa. Contains purine/pyrimidine phosphoribosyl transferases signature (PS00103). SEEMS TO BELONG TO PURINE/PYRIMIDINE PHOSPHORIBOSYL TRANSFERASE FAMILY.; hypothetical protein	complement(3621570..3622211)	Mycobacterium tuberculosis H37Rv	888757
NP_217760.1	CDS	Rv3243c	NC_000962.2	3622249	3623091	R	Rv3243c, (MTCY20B11.18c), len: 280 aa. Hypothetical unknown protein.; hypothetical protein	complement(3622249..3623091)	Mycobacterium tuberculosis H37Rv	888810
NP_217761.1	CDS	lpqB	NC_000962.2	3623159	3624910	R	Rv3244c, (MTCY20B11.19c), len: 583 aa. Probable lpqB, conserved lipoprotein; contains appropriately placed lipoprotein signature (PS00013). Equivalent to Q9CCJ0|LPQB|ML0775 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (589 aa), FASTA scores: opt: 3375, E(): 1.4e-186, (87.9% identity in 579 aa overlap). Also similar to various proteins (in particular transferases) e.g. Q9KYX0|SCE33.13c PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (615 aa), FASTA scores: opt: 228, E(): 1.3e-05, (25.5% identity in 624 aa overlap); O87992|BBLPS1.19c PUTATIVE GLUTAMINE AMIDOTRANSFERASE from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (628 aa), FASTA scores: opt: 162, E(): 0.079, (28.05% identity in 171 aa overlap); Q9L2F4|SC7A8.01 PUTATIVE SUGAR KINASE (FRAGMENT) from Streptomyces coelicolor (434 aa), FASTA scores: opt: 143, E(): 0.72, (27.65% identity in 293 aa overlap); etc.; lipoprotein LpqB	complement(3623159..3624910)	Mycobacterium tuberculosis H37Rv	888815
NP_217762.1	CDS	mtrB	NC_000962.2	3624910	3626613	R	Rv3245c, (MTCY20B11.20c), len: 567 aa. mtrB, sensor-like histidine kinase (EC 2.7.3.-) (see citations below), equivalent to Q9CCJ1|MTRB OR ML0774 PUTATIVE TWO-COMPONENT SYSTEM SENSOR KINASE from Mycobacterium leprae (562 aa), FASTA scores: opt: 3208, E(): 7.4e-173, (88.7% identity in 566 aa overlap). Also similar to others e.g. Q9KYW9|SCE33.14c PUTATIVE TWO-COMPONENT SYSTEM HISTIDINE KINASE from Streptomyces coelicolor (688 aa), FASTA scores: opt: 1355, E(): 1.1e-68, (48.95% identity in 515 aa overlap); etc. Relatives in Mycobacterium tuberculosis are: MTCY369.03, E(): 1.5e-22; MTCY20G9.16, E(): 1.9e-17. SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES.; two component sensory transduction histidine kinase MTRB	complement(3624910..3626613)	Mycobacterium tuberculosis H37Rv	888719
NP_217763.1	CDS	mtrA	NC_000962.2	3626663	3627349	R	Rv3246c, (MTCY20B11.21c), len: 228 aa. mtrA, transcriptional activator, response regulator (see citations below), equivalent to Q9CCJ2|MTRA|ML0773 PUTATIVE TWO-COMPONENT RESPONSE REGULATOR from Mycobacterium leprae (228 aa), FASTA scores: opt: 1458, E(): 1.4e-85, (98.7% identity in 228 aa overlap). Also highly similar to others e.g. Q9F9J5|SCRA PUTATIVE RESPONSE REGULATOR from Streptomyces coelicolor (228 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa overlap); Q9KYW8|SCE33.15c PUTATIVE TWO-COMPONENT SYSTEM RESPONSE REGULATOR from Streptomyces coelicolor (229 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa overlap); Q9F868|REGX3 RESPONSE REGULATOR REGX3 from Mycobacterium smegmatis (228 aa), FASTA scores: opt: 730, E(): 2.3e-39, (50.90% identity in 222 aa overlap); etc. Relatives in Mycobacterium tuberculosis are: U01971|MTU01971_1; Q11156|RGX3_MYCTU; MTCY20G9.17, E(): 0; MTCY31.31c, E(): 3.4e-29; MTCY369.02, E(): 5.7e-28. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Experiments showed mtrA is differentially expressed in virulent and avirulent strains during growth in macrophages.; two component sensory transduction transcriptional regulatory protein MTRA	complement(3626663..3627349)	Mycobacterium tuberculosis H37Rv	888743
NP_217764.1	CDS	tmk	NC_000962.2	3627419	3628063	R	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase	complement(3627419..3628063)	Mycobacterium tuberculosis H37Rv	888740
NP_217765.1	CDS	sahH	NC_000962.2	3628160	3629647	R	catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase	complement(3628160..3629647)	Mycobacterium tuberculosis H37Rv	888746
NP_217766.1	CDS	Rv3249c	NC_000962.2	3629752	3630387	R	Rv3249c, (MTCY20B11.24c), len: 211 aa. Possible transcriptional regulatory protein, tetR family, with similarity to several e.g. Q9AE61|ALKB1 PUTATIVE TETR-REGULATORY from Rhodococcus erythropolis (208 aa), FASTA scores: opt: 503, E(): 7.7e-26, (40.6% identity in 192 aa overlap); CAC37620 PUTATIVE TETR-REGULATORY PROTEIN from Prauserella rugosa (212 aa), FASTA scores: opt: 246, E(): 4.4e-09, (27.95% identity in 186 aa overlap); Q9K4B0|SC7E4.06 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (203 aa), FASTA scores: opt: 224, E(): 1.1e-07, (34.5% identity in 197 aa overlap); Q11063|YC55_MYCTU|Rv1255c|MT1294|MTCY50.27 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 191, E(): 1.6e-05, (28.35% identity in 180 aa overlap); etc. Equivalent to AAK47689 from Mycobacterium tuberculosis strain CDC1551 (230 aa) but shorter 19 aa. COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Possible helix-turn helix motif at aa 44-65 (+6.66 SD).; TetR family transcriptional regulator	complement(3629752..3630387)	Mycobacterium tuberculosis H37Rv	888741
NP_217767.1	CDS	rubB	NC_000962.2	3630384	3630566	R	Rv3250c, (MTCY20B11.25c), len: 60 aa. Probable rubB, rubredoxin, highly similar to other rubredoxins e.g. Q9AE66|RUBA4 from Rhodococcus erythropolis (60 aa), FASTA scores: opt: 391, E(): 2.2e-21, (83.05% identity in 59 aa overlap); Q9AE63|RUBA2 from Rhodococcus erythropolis (63 aa), FASTA scores: opt: 380, E(): 1.4e-20, (83.9% identity in 56 aa overlap); P42453|RUBR_ACICA|RUBA from Acinetobacter calcoaceticus (54 aa), FASTA scores: opt: 315, E(): 4.9e-16, (69.8% identity in 53 aa overlap); Q9HTK7|PA5351 from Pseudomonas aeruginosa (55 aa), FASTA scores: opt: 298, E(): 8e-15, (64.15% identity in 53 aa overlap); Q9PGC3|XF0379 from Xylella fastidiosa (57 aa), FASTA scores: opt: 263, E(): 2.5e-12, (59.25% identity in 54 aa overlap); etc. Also similar to neighbouring ORF M. tuberculosis RubA (MTCY20B11.26c). Contains rubredoxin signature (PS00202). BELONGS TO THE RUBREDOXIN FAMILY.; rubredoxin RubB	complement(3630384..3630566)	Mycobacterium tuberculosis H37Rv	888744
NP_217768.1	CDS	rubA	NC_000962.2	3630571	3630738	R	Rv3251c, (MTCY20B11.26c), len: 55 aa. Probable rubA, rubredoxin, highly similar to other rubredoxins (but sometimes shorter) e.g. Q9AE67|RUBA3 from Rhodococcus erythropolis (61 aa), FASTA scores: opt: 335, E(): 1e-17, (73.6% identity in 53 aa overlap); P00272|RUB2_PSEOL|ALKG from Pseudomonas oleovorans (172 aa), FASTA scores: opt: 278, E(): 2.7e-13, (65.3% identity in 49 aa overlap); CAC38028|ALKG from Alcanivorax borkumensis (174 aa), FASTA scores: opt: 271, E(): 8.6e-13, (62.0% identity in 50 aa overlap); Q9WWW4|ALKG from Pseudomonas putida (175 aa), FASTA scores: opt: 270, E(): 1e-12, (61.8% identity in 55 aa overlap); etc. Also highly similar to C-terminus of Q9XBM1|ALKB ALKANE 1-MONOOXYGENASE (EC 1.14.15.3) from Prauserella rugosa (490 aa), FASTA scores: opt: 296, E(): 2.9e-14, (75.5% identity in 49 aa overlap). Also similar to neighbouring ORF Mycobacterium tuberculosis rubB (MTCY20B11.25c). Contains rubredoxin signature (PS00202). BELONGS TO THE RUBREDOXIN FAMILY.; rubredoxin RUBA	complement(3630571..3630738)	Mycobacterium tuberculosis H37Rv	888747
NP_217769.1	CDS	alkB	NC_000962.2	3630738	3631988	R	Rv3252c, (MTCY20B11.27c), len: 416 aa. Probable alkB, transmembrane alkane-1-monooxygenase (EC 1.14.15.3), highly similar to many (see Marin et al., 2001) e.g. Q9AE68|ALKB2 from Rhodococcus erythropolis (408 aa), FASTA scores: opt: 2018, E(): 9.6e-122, (68.6% identity in 415 aa overlap); Q9AFD5|ALKB from Nocardioides sp. CF8 (483 aa), FASTA scores: opt: 1485, E(): 1.4e-87, (56.55% identity in 405 aa overlap); Q9XAU0|ALKB1 from Rhodococcus erythropolis (391 aa), FASTA scores: opt: 1400, E(): 3.3e-82, (62.6% identity in 396 aa overlap); Q9XBM1|ALKB from Prauserella rugosa (490 aa), FASTA scores: opt: 1266, E(): 1.5e-73, (57.55% identity in 410 aa overlap); CAC40954|ALKB4 from Rhodococcus erythropolis (386 aa), FASTA scores: opt: 1190, E(): 9.1e-69, (54.3% identity in 383 aa overlap); etc.; transmembrane alkane 1-monooxygenase AlkB	complement(3630738..3631988)	Mycobacterium tuberculosis H37Rv	888690
NP_217770.1	CDS	Rv3253c	NC_000962.2	3632097	3633584	R	Rv3253c, (MTCY20B11.28c), len: 495 aa. Possible cationic amino acid transporter, integral membrane protein, similar to many e.g. O69844|SC1C3.02 PUTATIVE CATIONIC AMINO ACID TRANSPORTER from Streptomyces coelicolor (503 aa), FASTA scores: opt: 1649, E(): 5.8e-92, (52.6% identity in 485 aa overlap); Q9AE69 PUTATIVE TRANSPORTER (FRAGMENT) from Rhodococcus erythropolis (385 aa), FASTA scores: opt: 1594, E(): 9.7e-89, (62.0% identity in 387 aa overlap); Q9PBD7|XF2207 CATIONIC AMINO ACID TRANSPORTER from Xylella fastidiosa (483 aa), FASTA scores: opt: 1079, E(): 1.2e-57, (40.55% identity in 493 aa overlap); Q9SRU9|F20H23.25 PUTATIVE CATIONIC AMINO ACID TRANSPORTER from Arabidopsis thaliana (Mouse-ear cress) (614 aa), FASTA scores: opt: 802, E(): 6.7e-41, (36.4% identity in 445 aa overlap); P30823|CTR1_RAT|SLC7A1|ATRC1 HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1 from Rattus norvegicus (Rat) (624 aa), FASTA scores: opt: 782, E(): 1.1e-39, (36.1% identity in 432 aa overlap); etc. Relatives in Mycobacterium tuberculosis include: MTCY3G12.14, E(): 5.6e-31; MTCY39.19, E(): 1.6e-14. SEEMS TO BELONG TO THE APC FAMILY.; cationic amino acid transport integral membrane protein	complement(3632097..3633584)	Mycobacterium tuberculosis H37Rv	888739
NP_217771.1	CDS	Rv3254	NC_000962.2	3633675	3635063	D	Rv3254, (MTCY20B11.29), len: 462 aa. Conserved hypothetical protein, similar to CAC37877|SC1G7.02 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (440 aa), FASTA scores: opt: 606, E(): 6.2e-31, (31.7% identity in 445 aa overlap); O86550|SC1F2.13c HYPOTHETICAL 50.7 KDA PROTEIN from Streptomyces coelicolor (476 aa), FASTA scores: opt: 577, E(): 4.5e-29, (32.5% identity in 400 aa overlap); Q9L0A8|SCC24.09 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (468 aa), FASTA scores: opt: 380, E(): 1.3e-16, (30.7% identity in 391 aa overlap); BAB48792|MLL1411 PROBABLE FAD-DEPENDENT MONOOXYGENASE from Rhizobium loti (Mesorhizobium loti) (421 aa), FASTA scores: opt: 128, E(): 1.1, (25.2% identity in 397 aa overlap); Q9L7X9|BENF BENZOATE-SPECIFIC PORIN-LIKE PROTEIN from Pseudomonas putida (397 aa), FASTA scores: opt: 119, E(): 4, (24.85% identity in 157 aa overlap); etc. Also similar to N-terminus of AAK46259|MT1987 PUTATIVE FERREDOXIN REDUCTASE, ELECTRON TRANSFER COMPONENT from Mycobacterium tuberculosis strain CDC1551 (839 aa), FASTA scores: opt: 493, E(): 1.5e-23, (30.65% identity in 382 aa overlap).; hypothetical protein	3633675..3635063	Mycobacterium tuberculosis H37Rv	887237
NP_217772.1	CDS	manA	NC_000962.2	3635041	3636267	R	Rv3255c, (MTCY20B11.30c), len: 408 aa. Probable manA, mannose-6-phosphate isomerase (EC 5.3.1.8), equivalent to Q9CCJ5|MANA|ML0765 PUTATIVE MANNOSE-6-PHOSPHATE ISOMERASE from Mycobacterium leprae (410 aa), FASTA scores: opt: 2271, E(): 1.6e-133, (84.45% identity in 411 aa overlap). Also similar to many others e.g. Q9KZL9|MANA from Streptomyces coelicolor (383 aa), FASTA scores: opt: 946, E(): 2.4e-51, (44.4% identity in 403 aa overlap); Q9KV87|VC0269 from Vibrio cholerae (399 aa), FASTA scores: opt: 726, E(): 1.1e-37, (34.15% identity in 404 aa overlap); Q9CMJ5|PMI|PM0829 from Pasteurella multocida (400 aa), FASTA scores: opt: 640, E(): 2.4e-32, (32.5% identity in 391 aa overlap); etc. SIMILAR TO FAMILY 1 OF MANNOSE-6-PHOSPHATE ISOMERASES.; mannose-6-phosphate isomerase	complement(3635041..3636267)	Mycobacterium tuberculosis H37Rv	888698
NP_217773.1	CDS	Rv3256c	NC_000962.2	3636275	3637315	R	Rv3256c, (MTV015.01c-MTCY20B11.31c), len: 346 aa. Conserved hypothetical protein, equivalent to Q9CCJ6|ML0764 HYPOTHETICAL PROTEIN from Mycobacterium leprae (365 aa), FASTA scores: opt: 1574, E(): 1.4e-82, (75.35% identity in 365 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces coelicolor (375 aa), FASTA scores: opt: 171, E(): 0.012, (31.1% identity in 376 aa overlap); P55709|Y4YA_RHISN from Rhizobium sp. strain NGR234 (457 aa), FASTA scores: opt: 140, E(): 0.84, (28.75% identity in 233 aa overlap). TBparse score is 0.878.; hypothetical protein	complement(3636275..3637315)	Mycobacterium tuberculosis H37Rv	888696
NP_217774.1	CDS	manB	NC_000962.2	3637312	3638709	R	converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase/phosphoglucomutase	complement(3637312..3638709)	Mycobacterium tuberculosis H37Rv	888699
NP_217775.1	CDS	Rv3258c	NC_000962.2	3638811	3639302	R	Rv3258c, (MTV015.03c), len: 163 aa. Conserved hypothetical protein, equivalent to Q9CCJ8|ML0762 HYPOTHETICAL PROTEIN from Mycobacterium leprae (165 aa), FASTA scores: opt: 840, E(): 9.9e-42, (76.9% identity in 169 aa overlap). Also similar to Q9KZL4|SCE34.11c HYPOTHETICAL 15.0 KDA PROTEIN from Streptomyces coelicolor (140 aa), FASTA scores: opt: 353, E(): 1.1e-13, (48.3% identity in 147 aa overlap); and shows really weak similarity to other bacterial proteins. TBparse score is 0.928.; hypothetical protein	complement(3638811..3639302)	Mycobacterium tuberculosis H37Rv	888694
NP_217776.1	CDS	Rv3259	NC_000962.2	3639425	3639844	D	Rv3259, (MTV015.04), len: 139 aa. Conserved hypothetical protein, equivalent, but shorter 29 aa, to Q9CCJ9|ML0761 HYPOTHETICAL PROTEIN from Mycobacterium leprae (167 aa), FASTA scores: opt: 846, E(): 2.2e-47, (89.2% identity in 139 aa overlap). C-terminus highly similar to Q9S425 HYPOTHETICAL 6.0 KDA PROTEIN (FRAGMENT) from Mycobacterium smegmatis (54 aa), FASTA scores: opt: 275, E(): 2.7e-11, (81.15% identity in 53 aa overlap). Also similar to Q9KZL3|SCE34.12 from Streptomyces coelicolor (117 aa), FASTA scores: opt: 152, E(): 0.004, (34.15% identity in 126 aa overlap). Equivalent to AAK47699 from Mycobacterium tuberculosis strain CDC1551 (175 aa) but shorter 36 aa. TBparse score is 0.884.; hypothetical protein	3639425..3639844	Mycobacterium tuberculosis H37Rv	888697
NP_217777.1	CDS	whiB2	NC_000962.2	3639872	3640141	R	Rv3260c, (MTV015.05c), len: 89 aa. Probable whiB2 (alternate gene name: whmD), WhiB-like regulatory protein (see Hutter & Dick 1999), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q9CCK0|WHIB2|ML0760 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (89 aa), FASTA scores: opt: 550, E(): 6.1e-31, (85.4% identity in 89 aa overlap). Also similar to others e.g. Q9S426 WHMD REGULATORY PROTEIN (see Gomez & Bishai 2000) from Mycobacterium smegmatis (129 aa), FASTA scores: opt: 488, E(): 1.4e-26, (83.55% identity in 85 aa overlap); Q06387|WHIB-STV WHIB-STV PROTEIN from Streptomyces griseocarneus (87 aa), FASTA scores: opt: 443, E(): 1.2e-23, (74.7% identity in 83 aa overlap); Q05429|WHIB|WHIB1 TRANSCRIPTION-LIKE FACTOR WHIB from Streptomyces aureofaciens (87 aa), FASTA scores: opt: 442, E(): 1.3e-23, (74.7% identity in 83 aa overlap); etc. Equivalent to AAK47700 WhiB-related protein from Mycobacterium tuberculosis strain CDC1551 (123 aa) but shorter 34 aa. Also similar to other Mycobacterium tuberculosis proteins: MTCY07D11.07c (45.1% identity in 71 aa overlap) and MTCY78.13c (37.4% identity in 91 aa overlap). Start chosen by homology but ORF continues to ATG upstream at 3754.; whmD; transcriptional regulatory protein WHIB-like WHIB2	complement(3639872..3640141)	Mycobacterium tuberculosis H37Rv	888687
NP_217778.1	CDS	fbiA	NC_000962.2	3640543	3641538	D	catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase	3640543..3641538	Mycobacterium tuberculosis H37Rv	888701
NP_217779.1	CDS	fbiB	NC_000962.2	3641535	3642881	D	catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase	3641535..3642881	Mycobacterium tuberculosis H37Rv	888693
NP_217780.1	CDS	Rv3263	NC_000962.2	3643177	3644838	D	Rv3263, (MTCY71.03), len: 553 aa. Probable DNA methylase (EC 2.1.1.-), equivalent to Q9CCK4|ML0756 PROBABLE DNA METHYLASE from Mycobacterium leprae (555 aa), FASTA scores: opt: 2980, E(): 2.1e-184, (81.9% identity in 541 aa overlap). Also similar to others e.g. P25240|MT57_ECOLI|ECO57IM MODIFICATION METHYLASE from Escherichia coli (544 aa), FASTA scores: opt: 595, E(): 1e-30, (30.35% identity in 507 aa overlap); P25201|MTA1_ACICA|ACCIM MODIFICATION METHYLASE ACCI from Acinetobacter calcoaceticus (540 aa), FASTA scores: opt: 366, E(): 5.7e-16, (23.35% identity in 467 aa overlap); Q56752|M-ACCI ACCI METHYLASE from Bergeyella zoohelcum (541 aa), FASTA scores: opt: 365, E(): 6.6e-16, (22.95% identity in 466 aa overlap); etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature. Alternative start site at aa 25.; DNA methylase (modification methylase) (methyltransferase)	3643177..3644838	Mycobacterium tuberculosis H37Rv	888691
YP_177951.1	CDS	manB	NC_000962.2	3644898	3645977	R	Rv3264c, (MTCY71.04c), len: 359 aa. manB (alternate gene name: hddC), D-alpha-D-mannose-1-phosphate guanylyltransferase (EC 2.7.7.-) (see citations below), equivalent to Q9CCK6|RMLA2|ML0753 PUTATIVE SUGAR-PHOSPHATE NUCLEOTIDYL TRANSFERASE from Mycobacterium leprae (358 aa), FASTA scores: opt: 2075, E(): 2.7e-115, (86.9% identity in 359 aa overlap). Also similar to others e.g. Q9KZK6|SCE34.20c PUTATIVE NUCLEOTIDE PHOSPHORYLASE from Streptomyces coelicolor (360 aa), FASTA scores: opt: 1314, E(): 2.2e-70, (57.0% identity in 358 aa overlap); Q9KZP4|SC1A8A.08 PUTATIVE MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Streptomyces coelicolor (831 aa), FASTA scores: opt: 699, E(): 8.6e-34, (34.45% identity in 354 aa overlap) (only similarity in N-terminus for this one); P74589|SLL1496 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Synechocystis sp. strain PCC 6803 (843 aa), FASTA scores: opt: 692, E(): 2.3e-33, (35.1% identity in 342 aa overlap) (only similarity in N-terminus for this one too); BAB59222|TVG0079558 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Thermoplasma volcanium (359 aa), FASTA scores: opt: 664, E(): 5.2e-32, (34.6% identity in 338 aa overlap); Q9ZTW5|GMP GDP-MANNOSE PYROPHOSPHORYLASE from Solanum tuberosum (Potato) (361 aa), FASTA scores: opt: 636, E(): 2.3e-30, (34.65% identity in 361 aa overlap); etc. BELONGS TO FAMILY 2 OF MANNOSE-6-PHOSPHATE ISOMERASES. Note that previously known as rmlA2.; hddC; D-alpha-D-mannose-1-phosphate guanylyltransferase MANB (D-alpha-D-heptose-1-phosphate guanylyltransferase)	complement(3644898..3645977)	Mycobacterium tuberculosis H37Rv	888715
YP_177952.1	CDS	wbbL1	NC_000962.2	3645979	3646884	R	Rv3265c, (MTCY71.05c), len: 301 aa. Probable wbbL1, dTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL A-3-L-RHAMNOSYL TRANSFERASE (EC 2.-.-.-) (see citations below), equivalent to Q9CCK7|WBBL|ML0752 PUTATIVE DTDP-RHAMNOSYL TRANSFERASE from Mycobacterium leprae (308 aa), FASTA scores: opt: 1788, E(): 3e-104, (85.05% identity in 301 aa overlap); and Q9RN50|WBBL|Q9RN49 (see note * below) DTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE from Mycobacterium smegmatis (296 aa), FASTA scores: opt: 1494, E(): 6.1e-86, (72.35% identity in 293 aa overlap). Note that previously known as wbbL. [* Note: UNPUBLISHED (experimental study on Mycobacterium smegmatis). Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases - The cell wall arabinogalactan linker formation enzyme, dTDP-Rha:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl transferase is essential for mycobacterial viability - Mills J.A., Motichka K., Jucker M., Wu H.P., Uhlic B.C., Stern R.J., Scherman M.S., Vissa V.D., Yan W., Pan F., Kimbrel S., Kundu M., McNeil M.].; wbbL; dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol	complement(3645979..3646884)	Mycobacterium tuberculosis H37Rv	888714
NP_217783.1	CDS	rmlD	NC_000962.2	3646895	3647809	R	Rv3266c, (MTCY71.06c), len: 304 aa. rmlD, dTDP-6-deoxy-L-lyxo-4-hexulose reductase (dTDP-rhamnose modification protein) (EC 1.-.-.-)(see citations below), highly similar to Q9CCK8 putative dTDP-rhamnose modification protein from Mycobacterium leprae (311 aa), FASTA scores, opt: 1440, E(): 1.1e-78, (74.7% identity in 312 aa overlap); and similar to several dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) e.g. STRL_STRGR|P29781 from Streptomyces griseus (304 aa), FASTA scores, opt: 788, E(): 0, (47.4% identity in 304 aa overlap).; dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD	complement(3646895..3647809)	Mycobacterium tuberculosis H37Rv	888704
NP_217784.1	CDS	Rv3267	NC_000962.2	3647885	3649381	D	Rv3267, (MTCY71.07), len: 498 aa. Conserved hypothetical protein, CPSA-related protein, equivalent to Q9CCK9|ML0750 HYPOTHETICAL PROTEIN from Mycobacterium leprae (489 aa), FASTA scores: opt: 2523, E(): 5e-138, (78.9% identity in 498 aa overlap); and Q50160|CPSA (HYPOTHETICAL PROTEIN CPSA) from Mycobacterium leprae (516 aa), FASTA scores: opt: 868, E(): 1.2e-42, (34.7% identity in 507 aa overlap). Also similar to O06347|CPSA|Rv3484|MTCY13E12.37 CPSA from Mycobacterium tuberculosis (512 aa), FASTA scores: opt: 928, E(): 4.2e-46, (37.35% identity in 498 aa overlap); and O53834|Rv0822c|MTV043.14c HYPOTHETICAL 72.9 KDA PROTEIN from Mycobacterium tuberculosis (684 aa), FASTA scores: opt: 434, E(): 1.5e-17, (30.9% identity in 541 aa overlap). Also similar to Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (507 aa), FASTA scores: opt: 437, E(): 8.1e-18, (28.55% identity in 469 aa overlap); O68907 FRNA PROTEIN from Streptomyces roseofulvus (770 aa), FASTA scores: opt: 388, E(): 7.6e-15, (32.6% identity in 267 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A.; hypothetical protein	3647885..3649381	Mycobacterium tuberculosis H37Rv	888713
NP_217785.1	CDS	Rv3268	NC_000962.2	3649420	3650109	D	Rv3268, (MTCY71.08), len: 229 aa. Conserved hypothetical protein, similar to Q9KZK4|SCE34.22 HYPOTHETICAL 27.1 KDA PROTEIN from Streptomyces coelicolor (263 aa), FASTA scores: opt: 442, E(): 5.9e-20, (40.1% identity in 242 aa overlap). Also weak similarity to N-terminal part (approximatively 1530 to 1740 residues) of O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 aa), FASTA scores: opt: 159, E(): 0.11, (30.35% identity in 224 aa overlap).; hypothetical protein	3649420..3650109	Mycobacterium tuberculosis H37Rv	888703
NP_217786.1	CDS	Rv3269	NC_000962.2	3650234	3650515	D	Rv3269, (MTCY71.09), len: 93 aa. Conserved hypothetical protein, similar to many Mycobacterium proteins and chaperonins/heat shock proteins e.g. Q9CCL0|ML0748 HYPOTHETICAL PROTEIN from Mycobacterium leprae (92 aa), FASTA scores: opt: 427, E(): 6.8e-21, (73.65% identity in 91 aa overlap); Q10865|Rv1993c|MT2049|MTCY39.26c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (90 aa), FASTA scores: opt: 313, E(): 1.2e-13, (60.7% identity in 84 aa overlap); P71542|Y968_MYCTU|Rv0968|MTCY10D7.06c (98 aa), FASTA scores: opt: 294, E(): 2.2e-12, (55.1% identity in 98 aa overlap); Q50827|MOPA|GROEL|CH60_MYCVA CHAPERONIN (PROTEIN CPN60) from Mycobacterium vaccae (120 aa), FASTA scores: opt: 107, E(): 2.1, (39.5% identity in 81 aa overlap); Q9AEB3|HSP65 HEAT SHOCK PROTEIN (FRAGMENT) from Mycobacterium gadium (122 aa), FASTA scores: opt: 102, E(): 4.4, (38.25% identity in 81 aa overlap); Q49374|CH60_MYCGN|MOPA|GROEL CHAPERONIN (PROTEIN CPN60) from Mycobacterium genavense (120 aa), FASTA scores: opt: 99, E(): 6.8, (40.25% identity in 82 aa overlap); etc.; hypothetical protein	3650234..3650515	Mycobacterium tuberculosis H37Rv	888709
NP_217787.1	CDS	ctpC	NC_000962.2	3650526	3652682	D	Rv3270, (MT3370, MTCY71.10), len: 718 aa. Probable ctpC, metal cation-transport ATPase P-type (EC 3.6.3.-), integral membrane protein, equivalent to Q9CCL1|CTPC|ML0747 PUTATIVE CATION TRANSPORT ATPASE from Mycobacterium leprae (725 aa), FASTA scores: opt: 3908, E(): 0, (85.95% identity in 713 aa overlap). Also similar to O66027|MTAA METAL TRANSPORTING ATPASE MTA72 from Mycobacterium tuberculosis (680 aa), FASTA scores: opt: 3756, E(): 5.5e-213, (91.45% identity in 679 aa overlap); and to other ATPases e.g. Q9ZHC7|SILP_SALTY PUTATIVE CATION TRANSPORTING P-TYPE ATPASE from Salmonella typhimurium (824 aa), FASTA scores: opt: 1145, E(): 1.3e-59, (36.55% identity in 643 aa overlap); Q9HX93|PA3920 PROBABLE METAL TRANSPORTING P-TYPE ATPASE from Pseudomonas aeruginosa (792 aa), FASTA scores: opt: 1140, E(): 2.4e-59, (35.95% identity in 745 aa overlap); etc. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB.; metal cation-transporting P-type ATPase C CtpC	3650526..3652682	Mycobacterium tuberculosis H37Rv	888705
NP_217788.1	CDS	Rv3271c	NC_000962.2	3652679	3653347	R	Rv3271c, (MTCY71.11c), len: 222 aa. Probable conserved integral membrane protein, similar to others e.g. Q9RD35|SCM1.07c from Streptomyces coelicolor (230 aa), FASTA scores: opt: 360, E(): 4.7e-16, (33.85% identity in 195 aa overlap); Q9X897|SCE2.02c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 357, E(): 7.3e-16, (33.85% identity in 195 aa overlap); Q9D0E0 2610024A01RIK PROTEIN from Mus musculus (Mouse) (288 aa), FASTA scores: opt: 191, E(): 3.7e-05, (23.65% identity in 207 aa overlap).; integral membrane protein	complement(3652679..3653347)	Mycobacterium tuberculosis H37Rv	888716
NP_217789.1	CDS	Rv3272	NC_000962.2	3653448	3654632	D	Rv3272, (MTCY71.12), len: 394 aa. Conserved hypothetical protein, similar to various proteins e.g. Q9I672|PA0446 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (407 aa), FASTA scores: opt: 643, E(): 6.8e-32, (33.15% identity in 389 aa overlap); Q9RJU8|SCF41.21 PUTATIVE RACEMASE from Streptomyces coelicolor (403 aa), FASTA scores: opt: 541, E(): 1.1e-25, (31.95% identity in 385 aa overlap); O87838|SC8A6.04c PUTATIVE TRANSFERASE from Streptomyces coelicolor (410 aa), FASTA scores: opt: 539, E(): 1.5e-25, (29.95% identity in 395 aa overlap); Q9I563|PA0882 from Pseudomonas aeruginosa (400 aa), FASTA scores: opt: 530, E(): 5.2e-25, (28.8% identity in 396 aa overlap); BAB60328|TVG1215416 L-CARNITINE DEHYDRATASE from Thermoplasma volcanium (399 aa), FASTA scores: opt: 529, E(): 6e-25, (32.9% identity in 383 aa overlap); etc. C-terminus is similar to Q49678|U00012_27|B1308_C3_195 from Mycobacterium leprae (130 aa) (60.0% identity in 115 aa overlap). Also partially similar to MTCY359_7 from M. tuberculosis (778 aa) (29.9% identity in 388 aa overlap).; hypothetical protein	3653448..3654632	Mycobacterium tuberculosis H37Rv	888702
NP_217790.1	CDS	Rv3273	NC_000962.2	3654637	3656931	D	Rv3273, (MTCY71.13), len: 764 aa. Probable transmembrane protein (N-terminal part is hydrophobic) with probable carbonic anhydrase activity (in C-terminal part) (EC 4.2.1.1). Possibly involved in transport of sulfate. Equivalent to Q9CBA3|ML2279 PUTATIVE TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium leprae (496 aa), FASTA scores: opt: 1637, E(): 1.8e-89, (59.15% identity in 487 aa overlap). Similar to various proteins (principally sulfate transporters) e.g. Q9X927|SCH5.25 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (830 aa), FASTA scores: opt: 1325, E(): 8e-71, (40.85% identity in 788 aa overlap); Q9I729|PA0103 PROBABLE SULFATE TRANSPORTER from Pseudomonas aeruginosa (523 aa), FASTA scores: opt: 1015, E(): 1.3e-52, (39.95% identity in 488 aa overlap); Q9KN88|VCA0077 SULFATE PERMEASE FAMILY PROTEIN from Vibrio cholerae (553 aa), FASTA scores: opt: 629, E(): 9.6e-30, (30.95% identity in 423 aa overlap); etc. C-terminal part (aa 550-764) shows similarity to carbonic anhydrase e.g. P27134|CYNT_SYNP7 CARBONIC ANHYDRASE (EC 4.2.1.1) (272 aa), FASTA scores: opt: 350, E(): 8.1e-15, (33.8% identity in 201 aa overlap). Contains PS00704 Prokaryotic-type carbonic anhydrases signature 1. SEEMS TO BELONG TO THE SULP FAMILY.; transmembrane carbonic anhydrase	3654637..3656931	Mycobacterium tuberculosis H37Rv	888700
NP_217791.1	CDS	fadE25	NC_000962.2	3656920	3658089	R	Rv3274c, (MTCY71.14c), len: 389 aa. Probable fadE25, Acyl-CoA Dehydrogenase (EC 1.3.99.-), equivalent to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE ACYL-CoA DEHYDROGENASE FADE25 from Mycobacterium leprae (389 aa), FASTA scores: opt: 2394, E(): 3.8e-143, (92.05% identity in 389 aa overlap). Also similar to many e.g. Q9RIQ5|FADE FATTY ACID ACYL-CoA DEHYDROGENASE from Streptomyces lividans (385 aa), FASTA scores: opt: 1692, E(): 4.9e-99, (67.35% identity in 383 aa overlap); P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa), FASTA scores: opt: 1212, E(): 7.2e-69, (51.85% identity in 376 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 1209, E(): 1.1e-68, (51.7% identity in 377 aa overlap); P52042|ACDS_CLOAB|BCD from Clostridium acetobutylicum (379 aa), FASTA scores: opt: 1056, E(): 4.6e-59, (44.6% identity in 379 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE25	complement(3656920..3658089)	Mycobacterium tuberculosis H37Rv	888731
NP_217792.1	CDS	purE	NC_000962.2	3658114	3658638	R	Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit	complement(3658114..3658638)	Mycobacterium tuberculosis H37Rv	888721
NP_217793.1	CDS	purK	NC_000962.2	3658635	3659924	R	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit	complement(3658635..3659924)	Mycobacterium tuberculosis H37Rv	888720
NP_217794.1	CDS	Rv3277	NC_000962.2	3659878	3660696	D	Rv3277, (MTCY71.17), len: 272 aa. Probable conserved transmembrane protein, equivalent, but longer 49 aa, to Q49673|B1308_C1_121|ML0734 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (228 aa), FASTA scores: opt: 1266, E(): 6.1e-78, (84.2% identity in 228 aa overlap). Also similar to various proteins (principally unknowns) e.g. Q9KZ84|SCE25.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (190 aa), FASTA scores: opt: 197, E(): 3.6e-06, (32.0% identity in 150 aa overlap); BAB50058|MLL3086 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (136 aa), FASTA scores: opt: 176, E(): 6.9e-05, (34.7% identity in 147 aa overlap); O29640|AF0615 HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (129 aa), FASTA scores: opt: 120, E(): 0.38, (23.35% identity in 120 aa overlap); Q9KJU8|GTCA TEICHOIC ACID GLYCOSYLATION PROTEIN from Listeria innocua (145 aa), FASTA scores: opt: 117, E(): 0.67, (23.85% identity in 151 aa overlap); etc. Equivalent to AAK47718 from Mycobacterium tuberculosis strain CDC1551 (256 aa) but longer 16 aa. Contains PS00044 Bacterial regulatory proteins, lysR family signature.; transmembrane protein	3659878..3660696	Mycobacterium tuberculosis H37Rv	888729
NP_217795.1	CDS	Rv3278c	NC_000962.2	3660651	3661169	R	Rv3278c, (MTCY71.18c), len: 172 aa. Probable conserved transmembrane protein, equivalent to Q9CCL2|ML0733 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (172 aa), FASTA scores: opt: 1024, E(): 6e-61, (83.15% identity in 172 aa overlap); and Q49672|B1308_F2_67 HYPOTHETICAL PROTEIN from Mycobacterium leprae (181 aa), FASTA scores: opt: 1024, E(): 6.3e-61, (83.15% identity in 172 aa overlap) (this is certainly the same putative protein but with N-terminus longer). Also some similarity to other hypothetical proteins (generally membrane proteins) e.g. O26822|MTH726 HYPOTHETICAL PROTEIN from Methanobacterium thermoautotrophicum (204 aa), FASTA scores: opt: 147, E(): 0.0079, (24.6% identity in 187 aa overlap); Q9X8H4|SCE9.01 HYPOTHETICAL 47.7 KDA PROTEIN (FRAGMENT) from Streptomyces coelicolor (436 aa), FASTA scores: opt: 151, E(): 0.0079, (28.1% identity in 153 aa overlap).; transmembrane protein	complement(3660651..3661169)	Mycobacterium tuberculosis H37Rv	888724
NP_217796.1	CDS	birA	NC_000962.2	3661212	3662012	R	catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase	complement(3661212..3662012)	Mycobacterium tuberculosis H37Rv	888726
NP_217797.1	CDS	accD5	NC_000962.2	3662062	3663708	D	Rv3280, (MTCY71.20, pccB), len: 548 aa. Probable accD5, propyonyl-CoA carboxylase beta chain 5 (EC 6.4.1.3), equivalent to P53002|PCCB_MYCLE|ACCD5|ML0731|B1308_C1_125 PROBABLE PROPIONYL-CoA CARBOXYLASE BETA CHAIN 5 from Mycobacterium leprae (549 aa), FASTA scores: opt: 3241, E(): 4e-192, (88.7% identity in 549 aa overlap). Also similar to many e.g. O87201|DTSR2 DTSR2 PROTEIN INVOLVED IN GLUTAMATE PRODUCTION from orynebacterium glutamicum (Brevibacterium flavum) (537 aa), FASTA scores: opt: 2604, E(): 6.9e-153, (74.1% identity in 529 aa overlap) (see Kimura et al., 1996); P53003|PCCB_SACER from Saccharopolyspora erythraea (Streptomyces erythraeus) (546 aa), FASTA scores: opt: 2466, E(): 2.2e-144, (70.2% identity in 530 aa overlap); O88155|DTSR1 DTSR1 PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (543 aa), FASTA scores: opt: 2375, E(): 8.8e-139, (67.1% identity in 529 aa overlap; Q9X4K7|PCCB from Streptomyces coelicolor (530 aa), FASTA scores: opt: 2360, E(): 7.3e-138, (67.9% identity in 533 aa overlap); O24789|MXPCCB from Myxococcus xanthus (524 aa), FASTA scores: opt: 1868, E(): 1.5e-107, (56.85% identity in 524 aa overlap); etc. Also similar with METHYLMALONYL-CoA DECARBOXYLASES e.g. O59018|PH1287 from Pyrococcus horikoshii (522 aa), FASTA scores: opt: 1841, E(): 6.7e-106, (54.15% identity in 528 aa overlap). Also similarity with MTCY427.28 (43.8% identity in 434 aa overlap). BELONGS TO THE ACCD/PCCB FAMILY.; propionyl-CoA carboxylase beta chain	3662062..3663708	Mycobacterium tuberculosis H37Rv	888725
NP_217798.1	CDS	Rv3281	NC_000962.2	3663689	3664222	D	Rv3281, (MTCY71.21), len: 177 aa. Conserved hypothetical protein, equivalent (but longer 14 aa and with a gap between aa 82-102) to AAK47723|MT3380 from Mycobacterium tuberculosis strain CDC1551 (142 aa), FASTA scores: opt: 830, E(): 3.1e-40, (86.5% identity in 163 aa overlap). C-terminus highly similar to Q49671|B1308_C3_211|ML0730 from Mycobacterium leprae (84 aa), FASTA scores: opt: 393, E(): 7.6e-16, (68.95% identity in 87 aa overlap).; hypothetical protein	3663689..3664222	Mycobacterium tuberculosis H37Rv	888732
NP_217799.1	CDS	maf	NC_000962.2	3664219	3664887	D	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein	3664219..3664887	Mycobacterium tuberculosis H37Rv	888718
NP_217800.1	CDS	sseA	NC_000962.2	3664928	3665821	D	Rv3283, (MTCY71.23), len: 297 aa. Probable sseA, thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent P46700|THT2_MYCLE|SSEA|ML0728|B1308_C1_127 PUTATIVE THIOSULFATE SULFURTRANSFERASE SSEA from Mycobacterium leprae (296 aa), FASTA scores: opt: 1742, E(): 5.5e-108, (83.45% identity in 296 aa overlap). Also highly similar to others e.g. Q9RXT9|DR0217 from Deinococcus radiodurans (286 aa), FASTA scores: opt: 1057, E(): 1.2e-62, (53.86% identity in 273 aa overlap); P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa), FASTA scores: opt: 1006, E(): 2.7e-59, (51.25% identity in 277 aa overlap); P71121|THTR_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (225 aa), FASTA scores: opt: 897, E(): 3.6e-52, (59.05% identity in 215 aa overlap); etc. Also highly similar to O05793|CYSA1|CYSA|Rv3117|MT3199|MTCY164.27|CYSA2|RV0815c| MT 0837|MTV043.07c|THTR_MYCTU PUTATIVE THIOSULFATE SULFURTRANSFERASE (EC 2.8.1.1) from Mycobacterium tuberculosis (277 aa), FASTA scores: opt: 955, E(): 6.3e-56, (50.2% identity in 271 aa overlap); and Q50036|THTR_MYCLE|CYSA|CYSA3|ML2198 PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium leprae (277 aa), FASTA scores: opt: 931, E(): 2.5e-54, (48.9% identity in 276 aa overlap). Shows some similarity to MTCY339.19c (30.3% identity in 254 aa overlap). Contains PS00683 Rhodanese C-terminal signature. BELONGS TO THE RHODANESE FAMILY. Thought to be differentially expressed within host cells (see Triccas et al., 1999).; thiosulfate sulfurtransferase SseA	3664928..3665821	Mycobacterium tuberculosis H37Rv	888717
NP_217801.1	CDS	Rv3284	NC_000962.2	3665818	3666249	D	Rv3284, (MTCY71.24, unknown), len: 143 aa. Conserved hypothetical protein, with similarity to other bacterial hypothetical proteins e.g. Q9RXU0|DR0216 from Deinococcus radiodurans (147 aa), FASTA scores: opt: 425, E(): 9.1e-21, (46.55% identity in 146 aa overlap); BAB37094|ECS3671 from Escherichia coli strain O157:H7 (147 aa), FASTA scores: opt: 187, E(): 2.2e-05, (29.5% identity in 139 aa overlap); AAG57925|YGDK from Escherichia coli strain O157:H7 EDL933 (147 aa), FASTA scores: opt: 187, E(): 2.2e-05, (32.05% identity in 139 aa overlap); etc.; hypothetical protein	3665818..3666249	Mycobacterium tuberculosis H37Rv	887966
NP_217802.1	CDS	accA3	NC_000962.2	3666357	3668159	D	Rv3285, (MTCY71.25), len: 600 aa. Probable accA3, bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain (EC 6.3.4.14) (see citations below) equivalent to P46392|BCCA_MYCLE|BCCA|ML0726|B1308_C1_129 ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN from Mycobacterium leprae (598 aa), FASTA scores: opt: 3510, E(): 1.1e-196, (89.3% identity in 601 aa overlap). Also highly similar to other proteins e.g. P71122|ACCBC ACYL COENZYME A CARBOXYLASE from Corynebacterium glutamicum (Brevibacterium flavum) (591 aa), FASTA scores: opt: 2776, E(): 5.6e-154, (71.95% identity in 592 aa overlap); Q54119|BCPA2 BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (591 aa), FASTA scores: opt: 2723, E(): 6.7e-151, (70.5% identity in 590 aa overlap); Q54105|BCPA BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (597 aa), FASTA scores: opt: 2721, E(): 8.9e-151, (70.05% identity in 594 aa overlap); Q9EWV4|2SCK31.20 PUTATIVE ACYL-CoA CARBOXYLASE COMPLEX A SUBUNIT from Streptomyces coelicolor (590 aa), FASTA scores: opt: 2626, E(): 2.9e-145, (68.25% identity in 595 aa overlap); etc. Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2, PS00188 Biotin-requiring enzymes attachment site. SIMILAR TO OTHER BIOTIN-DEPENDENT ENZYMES AND CARBAMOYL-PHOSPHATE SYNTHETASES.; bifunctional acetyl-/propionyl-coenzyme A carboxylase subunit alpha	3666357..3668159	Mycobacterium tuberculosis H37Rv	887912
NP_217803.1	CDS	sigF	NC_000962.2	3668169	3668954	R	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock; RNA polymerase sigma factor SigF	complement(3668169..3668954)	Mycobacterium tuberculosis H37Rv	888727
NP_217804.2	CDS	rsbW	NC_000962.2	3668951	3669388	R	Rv3287c, (MTCY71.27c), len: 145 aa. rsbW (alternate gene name: usfX), anti-sigma factor (see citations below), similar to Q49667|B1308_F3_89 from Mycobacterium leprae (75 aa), FASTA scores: opt: 308, E(): 2.5e-15, (72.2% identity in 72 aa overlap); Q9R3X8|PRS1|USHX|PRS PRS1 PROTEIN (ANTI-SIGMA FACTOR) from Streptomyces coelicolor (137 aa), FASTA scores: opt: 184, E(): 3.7e-06, (36.8% identity in 106 aa overlap); O50231 PUTATIVE SIGMA-B REGULATOR from Bacillus licheniformis (160 aa), FASTA scores: opt: 122, E(): 0.13, (23.9% identity in 92 aa overlap); and P17904|RSBW_BACSU ANTI-SIGMA B FACTOR (SIGMA-B NEGATIVE EFFECTOR RSBW) from Bacillus subtilis (160 aa), FASTA scores: opt: 108, E(): 1.3, (21.25% identity in 127 aa overlap). Equivalent to AAK47729 from Mycobacterium tuberculosis strain CDC1551 (145 aa) but longer 99 aa. INDUCTION BY HEAT SHOCK, SALT STRESS, OXIDATIVE STRESS, GLUCOSE LIMITATION AND OXYGEN LIMITATION. N-terminus shortened since first submission (previously 242 aa).; usfX; anti-sigma factor rsbW (sigma negative effector)	complement(3668951..3669388)	Mycobacterium tuberculosis H37Rv	887977
NP_217805.1	CDS	usfY	NC_000962.2	3669586	3669999	R	Rv3288c, (MTCY71.28c), len: 137 aa. usfY, putative protein (see citation below). Has no significant homologues. May not be contranscribed with the usfX and sigF proteins.; hypothetical protein	complement(3669586..3669999)	Mycobacterium tuberculosis H37Rv	888735
NP_217806.1	CDS	Rv3289c	NC_000962.2	3670034	3670411	R	Rv3289c, (MTCY71.29c), len: 125 aa. Possible transmembrane protein, showing slight similarity to other membrane proteins or glycoproteins.; transmembrane protein	complement(3670034..3670411)	Mycobacterium tuberculosis H37Rv	888736
NP_217807.1	CDS	lat	NC_000962.2	3670445	3671794	R	catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate; L-lysine aminotransferase	complement(3670445..3671794)	Mycobacterium tuberculosis H37Rv	887904
NP_217808.1	CDS	Rv3291c	NC_000962.2	3671845	3672297	R	Rv3291c, (MTCY71.31c), len: 150 aa. Probable transcriptional regulator asnC-family, similar to other regulatory proteins e.g. Q9RKY4|SC6D7.14 from Streptomyces coelicolor (165 aa), FASTA scores: opt: 503, E(): 9.1e-26, (50.35% identity in 143 aa overlap); Q9KYP0|SCD69.13 from Streptomyces coelicolor (167 aa), FASTA scores: opt: 310, E(): 2.7e-13, (37.2% identity in 129 aa overlap); BAB50701|MLL3910 from Rhizobium loti (Mesorhizobium loti) (152 aa), FASTA scores: opt: 282, E(): 1.6e-11, (39.55% identity in 129 aa overlap); O87635|LRP_KLEAE from Klebsiella aerogenes (163 aa), FASTA scores: opt: 279, E(): 2.5e-11, (38.1% identity in 147 aa overlap); etc. Contains helix-turn-helix motif at aa 22-43 (+3.94 SD). COULD BELONG TO THE ASNC FAMILY OF TRANSCRIPTIONAL REGULATORS.; AsnC family transcriptional regulator	complement(3671845..3672297)	Mycobacterium tuberculosis H37Rv	888728
NP_217809.1	CDS	Rv3292	NC_000962.2	3672328	3673575	D	Rv3292, (MTCY71.32), len: 415 aa. Conserved hypothetical protein, similar to P76097|YDCJ_ECOLI|B1423 HYPOTHETICAL 51.0 KDA PROTEIN from Escherichia coli strain K12 (447 aa), FASTA scores: opt: 747, E(): 5.6e-39, (38.55% identity in 449 aa overlap); BAB35451|ECS2028 HYPOTHETICAL 51.0 KDA PROTEIN from Escherichia coli strain O157:H7 (447 aa), FASTA scores: opt: 744, E(): 8.6e-39, (38.3% identity in 449 aa overlap); AAG56352|Z2297 PROTEIN from Escherichia coli O157:H7 EDL933 (212 aa), FASTA scores: opt: 454, E(): 4.6e-21, (41.75% identity in 206 aa overlap); and similar in part with Q49664|B1308_C1_136 from Mycobacterium leprae (71 aa), FASTA scores: opt: 305, E(): 3.2e-12, (70.0% identity in 70 aa overlap).; hypothetical protein	3672328..3673575	Mycobacterium tuberculosis H37Rv	888734
YP_177953.1	CDS	pcd	NC_000962.2	3673602	3675086	D	Rv3293, (MTCY71.33), len: 494 aa. Probable pcd, piperideine-6-carboxylic acid dehydrogenase (EC 1.5.-.-), highly similar to others e.g. O85725|PCD SEMIALDEHYDE DEHYDROGENASE from Streptomyces clavuligerus (512 aa), FASTA scores: opt: 2214, E(): 6.7e-121, (68.75% identity in 496 aa overlap) (see Alexander & Jensen 1998); Q9I4U7|PA1027 PROBABLE ALDEHYDE DEHYDROGENASE from Pseudomonas aeruginosa (529 aa), FASTA scores: opt: 1984, E(): 1.4e-107, (64.5% identity in 493 aa overlap); BAB49892|MLL2867 ALDEHYDE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 1964, E(): 2e-106, (62.8% identity in 476 aa overlap); Q9A8Y1|CC1216 ALDEHYDE DEHYDROGENASE from Caulobacter crescentus (507 aa), FASTA scores: opt: 1909, E(): 3.1e-103, (59.95% identity in 497 aa overlap); O54199|PCD PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE from Streptomyces clavuligerus (496 aa), FASTA scores: opt: 1748, E(): 6.4e-94, (60.6% identity in 467 aa overlap); and Q9F1U8|PCD PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE from 'Flavobacterium' lutescens (510 aa), FASTA scores: opt: 1656, E(): 1.4e-88, (54.05% identity in 481 aa overlap) (see Fujii et al., 2000); etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Note that ORF Rv3290c seems to encoded the putative lat enzyme. Note that previously known as aldB.; aldB; piperideine-6-carboxilic acid dehydrogenase	3673602..3675086	Mycobacterium tuberculosis H37Rv	888733
YP_177954.1	CDS	Rv3294c	NC_000962.2	3675186	3675995	R	Rv3294c, 269 aa. Conserved hypothetical protein, similar to several conserved hypothetical proteins from Mycobacterium tuberculosis: O07781|Rv0597c (411 aa), FASTA scores: opt: 682, E(): 3.6e-37, (44.85% identity in 243 aa overlap); O53329|Rv3179 (454 aa), FASTA scores: opt: 561, E(): 3.3e-29, (42.20% identity in 218 aa overlap); Q10849|YK08_MYCTU|Rv2008c (441 aa), FASTA scores: opt: 194, E(): 3.9e-05, (30.10% identity in 239 aa overlap). Also some similarity with proteins from other organisms. Replace previous Rv3294 on opposite strand.; hypothetical protein	complement(3675186..3675995)	Mycobacterium tuberculosis H37Rv	3205051
NP_217812.1	CDS	Rv3295	NC_000962.2	3676066	3676731	D	Rv3295, (MTCY71.35), len: 221 aa. Probable transcriptional regulator tetR-family, equivalent to Q9CCL4|ML0717 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (223 aa), FASTA scores: opt: 1260, E(): 7.2e-75, (85.45% identity in 220 aa overlap). Also highly similar to other streptomyces regulators e.g. Q9RD77|SCF43.11 from Streptomyces coelicolor (205 aa), FASTA scores: opt: 442, E(): 9.8e-22, (38.6% identity in 202 aa overlap); Q9RKY8|SC6D7.09 from Streptomyces coelicolor (220 aa), FASTA scores: opt: 215, E(): 5.9e-07, (31.85% identity in 135 aa overlap); Q9L0U5|SCD35.06 from Streptomyces coelicolor (240 aa), FASTA scores: opt: 214, E(): 7.4e-07, (28.2% identity in 156 aa overlap); etc. SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Contains potential helix-turn-helix motif at aa 33-54 (+4.42 SD).; TetR family transcriptional regulator	3676066..3676731	Mycobacterium tuberculosis H37Rv	887180
NP_217813.1	CDS	lhr	NC_000962.2	3676775	3681316	D	Rv3296, (MTCY71.36), len: 1512 aa. Probable lhr, ATP-dependent helicase (EC 3.6.1.-), similar to others e.g. P30015|LHR_ECOLI|RHLF|B1653 from Escherichia coli stain K12 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.55% identity in 1569 aa overlap); AAG56642|LHR from Escherichia coli stain O157:H7 EDL933 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.6% identity in 1561 aa overlap); O86821|SC7C7.16c from Streptomyces coelicolor (1690 aa), FASTA scores: opt: 2919, E(): 7e-159, (53.55% identity in 1703 aa overlap); Q9HYW9|PA3272 from Pseudomonas aeruginosa (1448 aa), FASTA scores: opt: 907, E(): 6.2e-44, (35.85% identity in 1512 aa overlap); etc. SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY AND TO HELICASE C-TERMINAL DOMAIN. Contains PS00017 ATP/GTP-binding site motif A and possible helix-turn-helix motif.; ATP-dependent helicase	3676775..3681316	Mycobacterium tuberculosis H37Rv	887503
NP_217814.1	CDS	nei	NC_000962.2	3681320	3682087	D	Rv3297, (MTCY71.37, MT3396), len: 255 aa. Probable nei, endonuclease VIII (EC 3.2.-.-) (see citation below), similar to others e.g. O86820|END8_STRCO|NEI|SC7C7.15c from Streptomyces coelicolor (276 aa), FASTA scores: opt: 770, E(): 1.2e-42, (50.35% identity in 268 aa overlap); P50465|END8_ECOLI|NEI|B0714 from Escherichia coli strain K12 (262 aa), FASTA scores: opt: 310, E(): 6.3e-13, (28.1% identity in 267 aa overlap); AAG55037|NEI from Escherichia coli strain O157:H7 EDL933 (263 aa), FASTA scores: opt: 301, E(): 2.4e-12, (27.7% identity in 267 aa overlap); etc. BELONGS TO THE FPG FAMILY.; endonuclease VIII	3681320..3682087	Mycobacterium tuberculosis H37Rv	887937
NP_217815.1	CDS	lpqC	NC_000962.2	3682110	3683024	R	Rv3298c, (MTCY71.38c), len: 304 aa. Possible lpqC, esterase lipoprotein (EC 3.1.-.-), equivalent to Q9CCL5|LPQC|ML0715 PUTATIVE SECRETED HYDROLASE from Mycobacterium leprae (304 aa), FASTA scores: opt: 1543, E(): 1.3e-87, (71.6% identity in 303 aa overlap); and Q49658|B1308_F2_43 TUBULIN FAMILY PROTEIN from Mycobacterium leprae (302 aa), FASTA scores: opt: 1541, E(): 1.7e-87, (72.0% identity in 300 aa overlap). Also similar to Q9I5Z3|PA0543 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (322 aa), FASTA scores: opt: 439, E(): 8.9e-20, (32.3% identity in 319 aa overlap); Q9F2K9|SCH63.19c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (348 aa), FASTA scores: opt: 394, E(): 5.5e-17, (30.25% identity in 334 aa overlap); etc. And similar to O86367|LPQP|Rv0671|MTCI376.03c from Mycobacterium tuberculosis strain H37Rv (280 aa), FASTA scores: opt: 519, E(): 9.8e-25, (39.25% identity in 275 aa overlap). Probably lipoprotein, esterase membrane-bound, with 18 aa signal sequence as it contains appropriately positioned (PS00013) Prokaryotic membrane lipoprotein lipid attachment site.; esterase lipoprotein LpqC	complement(3682110..3683024)	Mycobacterium tuberculosis H37Rv	887984
NP_217816.1	CDS	atsB	NC_000962.2	3683051	3685963	R	Rv3299c, (MTCI418A.01c, MTCY71.39c), len: 970 aa. Probable atsB, arylsulfatase (EC 3.1.6.1), similar to P51691|ARS_PSEAE|ATSA|PA0183 (alias CAA88421|ATSA) from Pseudomonas aeruginosa (535 aa), FASTA scores: opt: 645, E(): 5.8e-31, (32.0% identity in 550 aa overlap); Q9L4Y2|ATSA from Klebsiella pneumoniae (577 aa), FASTA scores: opt: 504, E(): 1.7e-22, (26.3% identity in 566 aa overlap); and P20713|ATSA|ARS_KLEAE (precursor) from Klebsiella pneumoniae (464 aa), FASTA scores: opt: 502, E(): 1.8e-22, (26.85% identity in 451 aa overlap). Also similar to Mycobacterium tuberculosis proteins O06776|MTI376.13c|ATSD|Rv0663 (787 aa) (43.6% identity in 796 aa overlap) and P95059|MTCY210.30|ATSA|R0711 (787 aa) (38.4% identity in 797 aa overlap). Equivalent to AAK47741 from Mycobacterium tuberculosis strain CDC1551 (992 aa) but shorter 22 aa. Contains PS00523 Sulfatases signature 1 and PS01095 Chitinases family 18 active site signature. BELONGS TO THE SULFATASE FAMILY.; arylsulfatase AtsB	complement(3683051..3685963)	Mycobacterium tuberculosis H37Rv	887500
NP_217817.1	CDS	Rv3300c	NC_000962.2	3685983	3686900	R	Rv3300c, (MTCI418A.02c), len: 305 aa. Conserved hypothetical protein, similar to various proteins (notably pseudoridine synthase family proteins) e.g. Q9RJ76|SCI41.08 PUTATIVE RIBOSOMAL PSEUDOURIDINE SYNTHASE from Streptomyces coelicolor (324 aa), FASTA scores: opt: 876, E(): 4.5e-48, (52.1% identity in 313 aa overlap); Q9I272|PA2043 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa), FASTA scores: opt: 676, E(): 1.8e-35, (42.55% identity in 268 aa overlap); Q9JZW8|NMB0867 YABO/YCEC/SFHB FAMILY PROTEIN from Neisseria meningitidis (serogroup B) (307 aa), FASTA scores: opt: 597, E(): 1.8e-30, (42.9% identity in 282 aa overlap); Q9JUY2|NMA1085 HYPOTHETICAL PROTEIN from Neisseria meningitidis (serogroup A) (307 aa), FASTA scores: opt: 597, E(): 1.8e-30, (42.9% identity in 282 aa overlap); Q12362|RIB2_YEAST|RIB2|YOL066C DRAP DEAMINASE (PSEUDOURIDINE SYNTHASE FAMILY PROTEIN) from Saccharomyces cerevisiae (Baker's yeast) (591 aa), FASTA scores: opt: 338, E(): 6.9e-14, (32.95% identity in 246 aa overlap); Q9RTS2|DR1684 PUTATIVE PSEUDOURIDINE SYNTHASE from Deinococcus radiodurans (321 aa), FASTA scores: opt: 319, E(): 6.5e-13, (32.75% identity in 235 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10786|Y04P_MYCTU|MTCY48.25c|Rv1540|MT1592 (308 aa) (28.8% identity in 299 aa overlap).; hypothetical protein	complement(3685983..3686900)	Mycobacterium tuberculosis H37Rv	887958
NP_217818.1	CDS	phoY1	NC_000962.2	3686912	3687577	R	Rv3301c, (MTCI418A.03c), len: 221 aa. Probable phoY1, phosphate-transport system regulatory protein, highly similar to Q50047|phoY|PHOU1|PHOY1|ML2188 PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 1 from Mycobacterium leprae (222 aa), FASTA scores: opt: 929, E(): 7.8e-51, (61.45% identity in 218 aa overlap). Also highly similar to Q9FCE2|2SCD46.42c PUTATIVE REGULATORY PROTEIN (FRAGMENT) from Streptomyces coelicolor (123 aa), FASTA scores: opt: 324, E(): 1.8e-13, (43.65% identity in 103 aa overlap); Q9L0R3|SCD8A.01c PUTATIVE PHOSPHATE TRANSPORT SYSTEM REGULATORY PROTEIN (FRAGMENT) from Streptomyces coelicolor (139 aa), FASTA scores: opt: 309, E(): 1.7e-12, (36.7% identity in 139 aa overlap); Q52989|PHOU_RHIME PHOSPHATE TRANSPORT SYSTEM PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (237 aa), FASTA scores: opt: 292, E(): 3.1e-11, (26.3% identity in 213 aa overlap); etc. And highly similar to Mycobacterium tuberculosis O53833|PHU2_MYCTU|MTV043_13c|PHOU2|PHOY2|Rv0821c|MT0843 PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2 (213 aa) (63.4% identity in 213 aa overlap). BELONGS TO THE PHOU FAMILY.; phosphate transporter PhoU	complement(3686912..3687577)	Mycobacterium tuberculosis H37Rv	887212
NP_217819.1	CDS	glpD2	NC_000962.2	3687685	3689442	R	Rv3302c, (MTCI418A.04c, MTV016.01c), len: 585 aa. Probable glpd2, glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), equivalent to P53435|GLPD_MYCLE|ML0713|L308_C1_179 GLYCEROL-3-PHOSPHATE DEHYDROGENASE (EC 1.1.99.5) from Mycobacterium leprae (585 aa), FASTA scores: opt: 3489, E(): 2.2e-198, (90.75% identity in 584 aa overlap). Also highly similar to many e.g. Q9L0I3|SCD63.06 from Streptomyces coelicolor (568 aa), FASTA scores: opt: 2203, E(): 1.6e-122, (59.95% identity in 564 aa overlap); Q9RVK8|DR1019 from Deinococcus radiodurans (522 aa), FASTA scores: opt: 949, E(): 1.4e-48, (37.0% identity in 538 aa overlap); BAB53412|MLR7270 from Rhizobium loti (Mesorhizobium loti) (505 aa), FASTA scores: opt: 861, E(): 2.2e-43, (37.3% identity in 488 aa overlap); P18158|GLPD_BACSU from B. subtilis (555 aa), FASTA scores: opt: 768, E(): 7.2e-38, (32.85% identity in 484 aa overlap); etc. Also similar to Mycobacterium tuberculosis protein Q10502|GLPD_MYCTU|MTCY427_31c|Rv2249c GLYCEROL-3-PHOSPHATE DEHYDROGENASE (516 aa), FASTA scores: opt: 843, E(): 2.6e-42, (36.5% identity in 515 aa overlap). Contains PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. COFACTOR: FAD (BY SIMILARITY). BELONGS TO THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY.; glycerol-3-phosphate dehydrogenase	complement(3687685..3689442)	Mycobacterium tuberculosis H37Rv	887211
NP_217820.1	CDS	lpdA	NC_000962.2	3689457	3690938	R	catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase	complement(3689457..3690938)	Mycobacterium tuberculosis H37Rv	887659
NP_217821.1	CDS	Rv3304	NC_000962.2	3691141	3691620	D	Rv3304, (MTV016.03), len: 159 aa. Hypothetical conserved protein, very similar to Q9CCL6|ML0711 HYPOTHETICAL PROTEIN from Mycobacterium leprae (159 aa), FASTA scores: opt: 1041, E(): 6.1e-62, (91.8% identity in 159 aa overlap); and Q49927|L308_F3_97 from M. leprae (174 aa), FASTA scores: opt: 974, E(): 1.8e-57, (91.2% identity in 149 aa overlap) . Also highly similar to Q9AD81|SCK13.10c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (145 aa), FASTA scores: opt: 615, E(): 7.8e-34, (60.55% identity in 147 aa overlap); and shows some similarity to other various hypotheticals proteins. ORF continues upstream with possible start at 2198 (equivalent to AAK47746 from Mycobacterium tuberculosis strain CDC1551 (212 aa) but shorter 53 aa). TBparse score is 0.922.; hypothetical protein	3691141..3691620	Mycobacterium tuberculosis H37Rv	887605
YP_177955.1	CDS	amiA1	NC_000962.2	3691639	3692808	R	Rv3305c, (MTV016.04c), len: 389 aa. Possible amiA1, N-acyl-L-amino acid amidohydrolase (or peptidase) (EC 3.5.1.-), similar to many proteins e.g. Q9AK43|2SCK8.09 PUTATIVE PEPTIDASE from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1015, E(): 3.9e-54, (50.8% identity in 374 aa overlap); Q9UZ30|PAB0873 AMINO ACID AMIDOHYDROLASE from Pyrococcus abyssi (383 aa), FASTA scores: opt: 823, E(): 1.6e-42, (38.2% identity in 369 aa overlap); O58453|PH0722 LONG HYPOTHETICAL AMINO ACID AMIDOHYDROLASE from Pyrococcus horikoshii (388 aa), FASTA scores: opt: 815, E(): 4.8e-42, (38.75% identity in 369 aa overlap); O34980|YTNL_BACSU HYPOTHETICAL 45.2 KDA PROTEIN from B. subtilis (416 aa), FASTA scores: opt: 805, E(): 2.1e-41, (37.85% identity in 367 aa overlap); Q9KCF8|BH1613 N-ACYL-L-AMINO ACID AMIDOHYDROLASE from Bacillus halodurans (404 aa), FASTA scores: opt: 795, E(): 8.1e-41, (37.7% identity in 382 aa overlap); BAB50445|MLR3583 HYPOTHETICAL HIPPURATE HYDROLASE from Rhizobium loti (Mesorhizobium loti) (387 aa), FASTA scores: opt: 761, E(): 8.9e-39, (37.65% identity in 385 aa overlap); Q9RXH4|DR0339 PUTATIVE N-ACYL-L-AMINO ACID AMIDOHYDROLASE from Deinococcus radiodurans (392 aa), FASTA scores: opt: 745, E(): 8.4e-38, (36.15% identity in 379 aa overlap); etc. Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. TBparse score is 0.905. Note that previously known as amiA.; amiA; N-acyl-L-amino acid amidohydrolase	complement(3691639..3692808)	Mycobacterium tuberculosis H37Rv	887545
YP_177956.1	CDS	amiB1	NC_000962.2	3692805	3693989	R	Rv3306c, (MTV016.05c), len: 394 aa. Probable amiB1, aminohydrolase (EC 3.5.1.-), similar to several belonging to peptidase family M40 (and to hypothetical proteins) e.g. P54983|AMHX_BACSU AMIDOHYDROLASE AMHX from Bacillus subtilis (EC 3.5.1.-) (389 aa), FASTA scores: opt: 286, E(): 9.9e-10, (26.6% identity in 351 aa overlap); P76052|ABGB_ECOLI Aminobenzoyl-glutamate utilizatio from Escherichia coli (481 aa), FASTA scores: opt: 383, E(): 2.1e-15, (30.5% identity in 328 aa overlap); P44765|YDAJ_HAEIN HYPOTHETICAL PROTEIN HI0584 from Haemophilus influenzae (423 aa), FASTA scores: opt: 297, E(): 2.4e-10, (29.6% identity in 274 aa overlap). TBparse score is 0.897. Note that previously known as amiB.; amiB; amidohydrolase AmiB1	complement(3692805..3693989)	Mycobacterium tuberculosis H37Rv	887645
NP_217824.1	CDS	deoD	NC_000962.2	3694054	3694860	D	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase	3694054..3694860	Mycobacterium tuberculosis H37Rv	887542
NP_217825.1	CDS	pmmB	NC_000962.2	3694864	3696468	D	Rv3308, (MTV016.07), len: 534 aa. Probable pmmB, phosphomannomutase (EC 5.4.2.8), equivalent to Q9CCL7|PMMB|ML0706 PUTATIVE PHOSPHO-SUGAR MUTASE from Mycobacterium leprae (538 aa), FASTA scores: opt: 2681, E(): 1.4e-150, (76.95% identity in 538 aa overlap). Also similar to others e.g. Q9AD82|SCK13.08c from Streptomyces coelicolor (549 aa), FASTA scores: opt: 1378, E(): 8.9e-74, (46.7% identity in 529 aa overlap); Q9ZHL4|PMM (FRAGMENT so no homology at N-terminus for this one) from Haemophilus ducreyi (443 aa), FASTA scores: opt: 935, E(): 9.6e-48, (39.4% identity in 449 aa overlap); P18159|YHXB_BACSU from Bacillus subtilis (565 aa), FASTA scores: opt: 776, E(): 2.7e-38, (31.7% identity in 574 aa overlap); etc. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. TBparse score is 0.898.; phosphomannomutase	3694864..3696468	Mycobacterium tuberculosis H37Rv	887541
NP_217826.1	CDS	upp	NC_000962.2	3696470	3697093	R	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase	complement(3696470..3697093)	Mycobacterium tuberculosis H37Rv	887944
NP_217827.1	CDS	Rv3310	NC_000962.2	3697198	3698097	D	Rv3310, (MTV016.09), len: 299 aa. Possible acid phosphatase (EC 3.1.3.2), similar to several fungal or bacterial acid phosphatases e.g. BAB50846|MLR4110 from Rhizobium loti (Mesorhizobium loti) (292 aa), FASTA scores: opt: 460, E(): 4.8e-22, (38.65% identity in 295 aa overlap); P34724|PHOA_ASPNG from Aspergillus niger (417 aa), FASTA scores: opt: 172, E(): 0.0013, (29.1% identity in 306 aa overlap); P08540|PHOX_KLULA from Kluyveromyces lactis (Yeast) (421 aa), FASTA scores: opt: 170, E(): 0.0018, (27.8% identity in 266 aa overlap); P37274|PHOA_PENCH from Penicillium chrysogenum (412 aa), FASTA scores: opt: 163, E(): 0.0049, (29.05% identity in 303 aa overlap); etc. TBparse score is 0.914.; acid phosphatase	3697198..3698097	Mycobacterium tuberculosis H37Rv	887988
NP_217828.1	CDS	Rv3311	NC_000962.2	3698121	3699383	D	Rv3311, (MTV016.10), len: 420 aa. Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical proteins Q9CCL8|ML0703 (423 aa), FASTA scores: opt: 2185, E(): 5.5e-120, (77.55% identity in 423 aa overlap); Q49918|L308_F2_61 (167 aa), FASTA scores: opt: 929, E(): 3.5e-47, (84.4% identity in 167 aa overlap) (similarity at C-terminus for this one); and Q49914|L308_F1_17 (166 aa), FASTA scores: opt: 900, E(): 1.7e-45, (79.0% identity in 162 aa overlap) (similarity at N-terminus for this one); Q49923|U0308N (86 aa) FASTA scores: opt: 149, E(): 0.052, (48.35% identity in 60 aa overlap); etc. Note that the Rv3311 corresponding protein in Mycobacterium leprae is similar to products of two adjacent ORFs. Also some similarity to Q9XI61|F9L1.1 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (523 aa), FASTA scores: opt: 134, E(): 1.8, (25.1% identity in 203 aa overlap). Equivalent to AAK47753 from Mycobacterium tuberculosis strain CDC1551 (431 aa) but shorter 12 aa. TBparse score is 0.888.; hypothetical protein	3698121..3699383	Mycobacterium tuberculosis H37Rv	887533
NP_217829.1	CDS	Rv3312c	NC_000962.2	3699404	3700330	R	Rv3312c, (MTV016.11), len: 308 aa. Hypothetical protein, similar to various proteins (principally hypothetical unknowns or hydrolases) e.g. Q9M9P2|T17B22.7 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (326 aa), FASTA scores: opt: 261, E(): 2.6e-09, (27.55% identity in 323 aa overlap); Q9FWB6 PUTATIVE ALPHA/BETA HYDROLASE from Oryza sativa (Rice) (354 aa), FASTA scores: opt: 241, E(): 4.9e-08, (28.9% identity in 301 aa overlap) (note that Q9FWB6 correspond to Q9FWB5 PUTATIVE ALPHA/BETA HYDROLASE (353 aa) but longer 1 aa; and to Q9AUW9 HYPOTHETICAL PROTEIN (332 aa) but longer 22 aa); Q9M382|F24B22.200 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (342 aa), FASTA scores: opt: 222, E(): 8e-07, (27.6% identity in 319 aa overlap); Q9HWM9|PA4152 PROBABLE HYDROLASE from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 176, E(): 0.00071, (29.2% identity in 209 aa overlap); Q9L3R2 HYDROLASE from Rhizobium leguminosarum (261 aa), FASTA scores: opt: 174, E(): 0.00071, (28.9% identity in 173 aa overlap); P49323|PRXC_STRLI|CPO|CPOL NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) from Streptomyces lividans (275 aa), FASTA scores: opt: 172, E(): 0.001, (30.9% identity in 194 aa overlap) (similarity only at N-terminus for this one); etc. Some similarity in N-terminal part to non-heme chloroperoxidases. Also similar to O05293|Rv1191|MTCI364.03 HYPOTHETICAL PROTEIN from M. tuberculosis (304 aa), FASTA scores: opt: 417, E(): 3.1e-19, (32.6% identity in 279 aa overlap) (note that Rv1191 is equivalent to AAK45485 from Mycobacterium tuberculosis strain CDC1551 but shorter 14 aa, and that AAK45485 is annoted Hydrolase, alpha/beta hydrolase family). TBparse score is 0.922.; hypothetical protein	complement(3699404..3700330)	Mycobacterium tuberculosis H37Rv	887939
YP_177957.1	CDS	Rv3312A	NC_000962.2	3700705	3701016	R	Rv3312A, len: 103 aa. Secreted protein antigen, described in Corixa patent as having N-terminal sequence YYWCPGQPFDPAWGP. Equivalent to AAK47756 from Mycobacterium tuberculosis strain CDC1551 (114 aa) but shorter 11 aa.; secreted protein antigen	complement(3700705..3701016)	Mycobacterium tuberculosis H37Rv	3205113
NP_217830.1	CDS	add	NC_000962.2	3701087	3702184	R	catalyzes the formation of inosine from adenosine; adenosine deaminase	complement(3701087..3702184)	Mycobacterium tuberculosis H37Rv	887994
NP_217831.1	CDS	deoA	NC_000962.2	3702184	3703467	R	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase	complement(3702184..3703467)	Mycobacterium tuberculosis H37Rv	887929
NP_217832.1	CDS	cdd	NC_000962.2	3703464	3703865	R	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase	complement(3703464..3703865)	Mycobacterium tuberculosis H37Rv	887975
NP_217833.1	CDS	sdhC	NC_000962.2	3704102	3704440	D	Rv3316, (MTV016.16), len: 112 aa. Probable sdhC, cytochrome B-556 of succinate dehydrogenase SdhC subunit (EC 1.3.99.1), transmembrane protein, equivalent (but shorter 35 aa) to Q9CCM0|SDHC|ML0699 PUTATIVE SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT from Mycobacterium leprae (153 aa), FASTA scores: opt: 692, E(): 1.2e-39, (88.4% identity in 112 aa overlap). Also similar to others e.g. Q9KZ88|SC5G8.26c from Streptomyces coelicolor (126 aa), FASTA scores: opt: 484, E(): 8.3e-26, (65.65% identity in 99 aa overlap); Q9RVR8|DR0954 from Deinococcus radiodurans (118 aa), FASTA scores: opt: 195, E(): 1.7e-06, (36.8% identity in 87 aa overlap); Q9HQ63|DHSD_HALN1|SDHD|SDHC|VNG1310G from Halobacterium sp. strain NRC-1 (130 aa), FASTA scores: opt: 192, E(): 2.9e-06, (37.85% identity in 74 aa overlap); P72109|DHSD_NATPH|SDHD|SDHC from Natronomonas pharaonis (Natronobacterium pharaonis) (130 aa), FASTA scores: opt: 183, E(): 1.1e-05, (35.15% identity in 74 aa overlap); etc. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. BELONGS TO THE CYTOCHROME B560 FAMILY. TBparse score is 0.893; succinate dehydrogenase cytochrome B-556 subunit	3704102..3704440	Mycobacterium tuberculosis H37Rv	887969
NP_217834.1	CDS	sdhD	NC_000962.2	3704437	3704871	D	Rv3317, (MTV016.17), len: 144 aa. Probable sdhD, membrane anchor of succinate dehydrogenase SdhD subunit (EC 1.3.99.1), equivalent (but shorter 19 aa) to Q49915|SDHD|ML0698|L308_F1_25 PUTATIVE SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN from Mycobacterium leprae (163 aa), FASTA scores: opt: 878, E(): 1.9e-51, (85.2% identity in 142 aa overlap). Also similar to others e.g. Q9KZ89|SC5G8.25c from Streptomyces coelicolor (160 aa), FASTA scores: opt: 553, E(): 6.6e-30, (58.85% identity in 141 aa overlap); Q9RVR9|DR0953 from Deinococcus radiodurans (125 aa), FASTA scores: opt: 251, E(): 5.5e-10, (37.15% identity in 113 aa overlap); O29573|DHSD_ARCFU|SDHD|AF0684 from Archaeoglobus fulgidus (117 aa), FASTA scores: opt: 160, E(): 0.00056, (25.95% identity in 108 aa overlap); etc. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. TBparse score is 0.905.; succinate dehydrogenase hydrophobic membrane anchor subunit SdhD	3704437..3704871	Mycobacterium tuberculosis H37Rv	887845
NP_217835.1	CDS	sdhA	NC_000962.2	3705000	3706772	D	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit	3705000..3706772	Mycobacterium tuberculosis H37Rv	887639
NP_217836.1	CDS	sdhB	NC_000962.2	3706772	3707563	D	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit	3706772..3707563	Mycobacterium tuberculosis H37Rv	887562
NP_217837.1	CDS	Rv3320c	NC_000962.2	3707642	3708070	R	Rv3320c, (MTV016.20c), len: 142 aa. Conserved hypothetical protein, similar to several hypothetical proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. P95023|Rv2530c|MTCY159.26 (139 aa), FASTA scores: opt: 292, E(): 4.8e-14, (41.5% identity in 135 aa overlap); O53219|Rv2494|MTV008.50 (141 aa), FASTA scores: opt: 287, E(): 1.1e-13, (41.6% identity in 125 aa overlap); O07760|Rv0617|MTCY19H5.04c (133 aa), FASTA scores: opt: 252, E(): 3.3e-11, (37.8% identity in 127 aa overlap); etc. TBparse score is 0.934.; hypothetical protein	complement(3707642..3708070)	Mycobacterium tuberculosis H37Rv	887245
NP_217838.1	CDS	Rv3321c	NC_000962.2	3708074	3708316	R	Rv3321c, (MTV016.21c), len: 80 aa. Conserved hypothetical protein, similar at N-terminal region to several proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. AAK48167|MT3800 DNA-BINDING PROTEIN (COPG FAMILY) from strain CDC1551 (74 aa), FASTA scores: opt: 142, E(): 0.0016, (48.85% identity in 43 aa overlap); AAK46916|MT2606 HYPOTHETICAL 8.0 KDA PROTEIN from strain CDC1551 (74 aa), FASTA scores: opt: 139, E(): 0.0026, (37.2% identity in 78 aa overlap); O50456|Rv1241|MTV006.13 HYPOTHETICAL 9.9 KDA PROTEIN from strain H37Rv (86 aa), FASTA scores: opt: 134, E(): 0.0066, (39.0% identity in 82 aa overlap); etc. TBparse score is 0.906.; hypothetical protein	complement(3708074..3708316)	Mycobacterium tuberculosis H37Rv	887577
YP_177958.1	CDS	Rv3322c	NC_000962.2	3708438	3709052	R	Rv3322c, (MTV016.22c), len: 204 aa. Conserved hypothetical protein, showing weak similarity to proteins including several methyltransferases (EC 2.1.1.-) e.g. Q9X9V1|ORF8 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (208 aa), FASTA scores: opt: 193, E(): 1e-05, (36.35% identity in 132 aa overlap); and Q9XA90|SCF43A.25c PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (215 aa), FASTA scores: opt: 161, E(): 0.0014, (32.05% identity in 131 aa overlap); P74712|SLR1183 HYPOTHETICAL 21.3 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (194 aa), FASTA scores: opt: 155, E(): 0.0032, (27.35% identity in 150 aa overlap); Q9ABW8|CC0102 RRNA METHYLTRANSFERASE RSMB from Caulobacter crescentus (429 aa), FASTA scores: opt: 148, E(): 0.018, (31.5% identity in 162 aa overlap); etc. Also highly similar to O05796|Rv3120|MTCY164.30 HYPOTHETICAL 21.8 KDA PROTEIN from Mycobacterium tuberculosis (200 aa), FASTA scores: opt: 691, E(): 1.2e-38, (56.5% identity in 200 aa overlap); and shows weak similarity to O69667|Rv3699|MTV025.047 PUTATIVE METHYLTRANSFERASE from Mycobacterium tuberculosis (233 aa), FASTA scores: opt: 155, E(): 0.0037, (29.15% identity in 168 aa overlap). TBparse score is 0.927.; methyltransferase	complement(3708438..3709052)	Mycobacterium tuberculosis H37Rv	887520
YP_177959.1	CDS	moaX	NC_000962.2	3709049	3709714	R	Rv3323c, (MTV016.23c), len: 221 aa. Probable moaX, MoaD-MoaE fusion protein, similar (whole or partial) to several MoaD and MoaE proteins e.g. Q9RR88|DR2607 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D/E from Deinococcus radiodurans (229 aa), FASTA scores: opt: 407, E(): 1.8e-18, (32.75% identity in 223 aa overlap); Q9K8I7|MOAE|BH3019 MOLYBDOPTERIN CONVERTING FACTOR (SUBUNIT 2) from Bacillus halodurans (156 aa), FASTA scores: opt: 375, E(): 1.3e-16, (41.65% identity in 132 aa overlap); O31705|MOAE MOLYBDOPTERIN CONVERTING FACTOR (SUBUNIT 2) from Bacillus subtilis (157 aa), FASTA scores: opt: 368, E(): 3.6e-16, (41.65% identity in 132 aa overlap); etc. C-terminus highly similar to O05795|MOAE_MYCTU|Rv3119|MT3201|MTCY164.29|MOAE1 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 733, E(): 5.4e-39, (76.2% identity in 143 aa overlap); and N-terminus highly similar to O05789|MOAD1|Rv3112|MTCY164.22 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D from Mycobacterium tuberculosis (83 aa), FASTA scores: opt: 333, E(): 3.2e-14, (65.05% identity in 83 aa overlap). TBparse score is 0.941.; MOAD-MOAE fusion protein MOAX	complement(3709049..3709714)	Mycobacterium tuberculosis H37Rv	887578
NP_217841.2	CDS	moaC	NC_000962.2	3709715	3710269	R	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC	complement(3709715..3710269)	Mycobacterium tuberculosis H37Rv	887981
NP_217842.1	CDS	Rv3325	NC_000962.2	3710433	3710759	D	Rv3325, (MTV016.25), len: 108 aa. Probable transposase for insertion element IS6110. BELONGS TO THE TRANSPOSASE FAMILY 8. TBparse score is 0.928.; transposase	3710433..3710759	Mycobacterium tuberculosis H37Rv	887314
NP_217843.1	CDS	Rv3326	NC_000962.2	<3710756	3711694	D	Rv3326, (MTV016.26), len: 312 aa. Probable transposase for insertion element IS6110. TBparse score is 0.926.; transposase	<3710756..3711694	Mycobacterium tuberculosis H37Rv	887563
NP_217844.1	CDS	Rv3327	NC_000962.2	3711749	3713461	D	Rv3327, (MTV016.27), len: 570 aa. Probable fusion protein. Indeed, N-terminal part corresponds to entire O07269 transposase of IS1547 (383 aa), and C-terminal part identical to MTCI249B.03c (210 aa). N-terminal part is identical to MTV042_7 (188 aa); C-terminal part (aa 378-570) is similar to hypothetical 20.5 kDa protein from Escherichia coli P76222|YNJA_ECOLI (182 aa), FASTA scores: opt: 292, E(): 5.3e-11, (32.6% identity in 181 aa overlap). TBparse score is 0.910.; transposase	3711749..3713461	Mycobacterium tuberculosis H37Rv	887965
NP_217845.1	CDS	sigJ	NC_000962.2	3713394	3714332	R	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigJ	complement(3713394..3714332)	Mycobacterium tuberculosis H37Rv	887964
NP_217846.1	CDS	Rv3329	NC_000962.2	3714392	3715708	D	Rv3329, (MTV016.29), len: 438 aa (start uncertain). Probable aminotransferase (EC 2.6.1.-), similar to many e.g. O86744|SC6A9.12 from Streptomyces coelicolor (457 aa), FASTA scores: opt: 2120, E(): 5.1e-125, (70.1% identity in 438 aa overlap); Q9I6J2|PA0299 from Pseudomonas aeruginosa (456 aa), FASTA scores: opt: 983, E(): 5.7e-54, (38.1% identity in 425 aa overlap); Q53196|Y4UB_RHISN from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (467 aa), FASTA scores: opt: 971, E(): 3.3e-53, (39.25% identity in 438 aa overlap); P33189|YHXA_BACSU from Bacillus subtilis (450 aa), FASTA scores: opt: 933, E(): 7.5e-51, (40.25% identity in 435 aa overlap); etc. Equivalent to AAK47775 from Mycobacterium tuberculosis strain CDC1551 (466 aa) but shorter 28 aa. COFACTOR: PYRIDOXAL PHOSPHATE. COULD BELONG TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. TBparse score is 0.881.; hypothetical protein	3714392..3715708	Mycobacterium tuberculosis H37Rv	888028
NP_217847.1	CDS	dacB1	NC_000962.2	3715777	3716994	D	Rv3330, (MTV016.30), len: 405 aa. Probable dacB1, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) (EC 3.4.16.4), equivalent to Mycobacterium leprae proteins Q9CCM2|ML0691 PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (411 aa), FASTA scores: opt: 2066, E(): 2.5e-102, (77.15% identity in 416 aa overlap); Q49917|L308_F1_36 (228 aa), FASTA scores: opt: 1241, E(): 7.9e-59, (78.9% identity in 232 aa overlap) (note that this protein corresponds to C-terminal part of the putative protein encoded by Rv3330, aa 174-405); and Q49921|PBPC (182 aa), FASTA scores: opt: 736, E(): 3.7e-32, (73.95% identity in 169 aa overlap) (note that this protein corresponds to N-terminal part of the putative protein encoded by Rv3330, aa 1-158); note L308_F1_36 (228 aa) and PBPC (182 aa) are two consecutive Mycobacterium leprae ORFs . Also similar to others e.g. Q9FC34|SC4G1.16c PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Streptomyces coelicolor (413 aa), FASTA scores: opt: 572, E(): 3.4e-23, (33.75% identity in 382 aa overlap); P35150|DACB_BACSU PENICILLIN-BINDING PROTEIN 5* PRECURSOR (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE) from Bacillus subtilis (382 aa), FASTA scores: opt: 422, E(): 2.8e-15, (31.3% identity in 249 aa overlap); Q9K8X5|DACB|BH2877 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (PENICILLIN-BINDING PROTEIN) from Bacillus halodurans (395 aa), FASTA scores: opt: 421, E(): 3.2e-15, (31.95% identity in 241 aa overlap); etc. Also similar to Mycobacterium tuberculosis Q10828|Rv2911|MTCY274.43 PROBABLE PENICILLIN-BINDING PROTEIN (BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY) (291 aa), FASTA scores: opt: 746, E(): 1.6e-32, (47.0% identity in 266 aa overlap). Has hydrophobic stretches at both N- and C-termini. Certainly membrane-bound protein. BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY. TBparse score is 0.871.; penicillin-binding protein DacB1	3715777..3716994	Mycobacterium tuberculosis H37Rv	887607
NP_217848.1	CDS	sugI	NC_000962.2	3717090	3718598	D	Rv3331, (MTV016.31), len: 502 aa (start uncertain). Probable sugI, sugar-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to several transporters e.g. P37021|GALP_ECOLI|B2943 GALACTOSE-PROTON SYMPORTER (GALACTOSE TRANSPORTER) from Escherichia coli strain K12 (464 aa), FASTA scores: opt: 818, E(): 1.8e-39, (31.85% identity in 446 aa overlap); P96742|YWTG METABOLITE-TRANSPORT-RELATED PROTEIN from Bacillus subtilis (457 aa), FASTA scores: opt: 810, E(): 5e-39, (33.2% identity in 428 aa overlap); AAG58074|GALP (alias BAB37242|ECS3819) GALACTOSE-PROTON SYMPORT OF TRANSPORT SYSTEM from Escherichia coli strain O157:H7 EDL933 (464 aa), FASTA scores: opt: 810, E(): 5.1e-39, (32.2% identity in 432 aa overlap); P46333|CSBC_BACSU|SS92BR PROBABLE METABOLITE TRANSPORT PROTEIN from Bacillus subtilis (461 aa), FASTA scores: opt: 792, E(): 5.4e-38, (33.7% identity in 442 aa overlap); etc. Equivalent to AAK47777|MT343 from Mycobacterium tuberculosis strain CDC1551 (500 aa) but with some divergence between residues 229 and 254. Contains PS00216 Sugar transport proteins signature 1 and PS00217 Sugar transport proteins signature 2. BELONGS TO THE SUGAR TRANSPORTER FAMILY. TBparse score is 0.869.; sugar-transport integral membrane protein SugI	3717090..3718598	Mycobacterium tuberculosis H37Rv	887504
NP_217849.1	CDS	nagA	NC_000962.2	3718595	3719746	D	Rv3332, (MTV016.32), len: 383 aa. Probable nagA, N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25), similar to many e.g. Q9KXV7|SCD95A.17c PUTATIVE DEACETYLASE from Streptomyces coelicolor (381 aa), FASTA scores: opt: 1090, E(): 1.6e-55, (47.8% identity in 385 aa overlap); Q9PDB4|XF1465 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Xylella fastidiosa (386 aa), FASTA scores: opt: 667, E(): 3.5e-31, (38.3% identity in 394 aa overlap); Q9AAZ9|CC0443 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Caulobacter crescentus (378 aa), FASTA scores: opt: 661, E(): 7.5e-31, (38.9% identity in 383 aa overlap); O34450||NAGA_BACSU N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Bacillus subtilis (396 aa), FASTA scores: opt: 571, E(): 1.2e-25, (32.45% identity in 376 aa overlap); etc. Equivalent to AAK47778 from Mycobacterium tuberculosis strain CDC1551 (346 aa) but longer 37 aa. BELONGS TO THE NAGA FAMILY. TBparse score is 0.881.; N-acetylglucosamine-6-phosphate deacetylase	3718595..3719746	Mycobacterium tuberculosis H37Rv	887518
NP_217850.1	CDS	Rv3333c	NC_000962.2	3719937	3720782	R	Rv3333c, (MTV016.33c), len: 281 aa. Hypothetical unknown pro-rich protein. Equivalent to AAK47780 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (265 aa) but longer 16 aa. TBparse score is 0.927.; hypothetical protein	complement(3719937..3720782)	Mycobacterium tuberculosis H37Rv	887632
NP_217851.1	CDS	Rv3334	NC_000962.2	3721257	3721697	D	Rv3334, (MTV016.34), len: 146 aa. Probable transcriptional regulator, similar to many regulatory proteins (notably mercury resistance operon regulators) e.g. Q9HXV1|PA3689 PROBABLE TRANSCRIPTIONAL REGULATOR MERR FAMILY from Pseudomonas aeruginosa (156 aa), FASTA scores: opt: 275, E(): 1.6e-11, (35.95% identity in 139 aa overlap); Q9AKR6|PBRR LEAD RESISTANCE OPERON REGULATOR from Ralstonia metallidurans strain CH34 (plasmid pMOL30) (145 aa), FASTA scores: opt: 267, E(): 5.2e-11, (35.8% identity in 134 aa overlap); P95838|MERR MERCURIC RESISTANCE OPERON REGULATOR from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (144 aa), FASTA scores: opt: 266, E(): 6e-11, (31.35% identity in 118 aa overlap); P22853|MERR_BACSR MERCURIC RESISTANCE OPERON REGULATOR from Bacillus sp. strain RC607 (132 aa), FASTA scores: opt: 262, E(): 1e-10, (34.6% identity in 130 aa overlap); etc. Contains probable helix-turn-helix motif at aa 1-22 (Score 1478, +4.22 SD). SEEMS TO BELONG TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.911.; MerR family transcriptional regulator	3721257..3721697	Mycobacterium tuberculosis H37Rv	887593
NP_217852.1	CDS	Rv3335c	NC_000962.2	3721731	3722600	R	Rv3335c, (MTV016.35c), len: 289 aa. Probable conserved integral membrane protein, equivalent to Q49909|ML0687 PUTATIVE MEMBRANE PROTEIN U0308AA from Mycobacterium leprae (313 aa), FASTA scores: opt: 1299, E(): 8.9e-75, (68.75% identity in 288 aa overlap). Also similar to other hypothetical bacterial proteins e.g. BAB37825|ECS4402 from Escherichia coli strain O157:H7 (alias P37642|YHJD_ECOLI|B3522 strain K12) (337 aa), FASTA scores: opt: 591, E(): 4.2e-30, (35.15% identity in 273 aa overlap); P45417|YHJD_ERWCH from Erwinia chrysanthemi (328 aa), FASTA scores: opt: 500, E(): 2.2e-24, (34.9% identity in 275 aa overlap); Q9KZA0|SC5G8.14 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (321 aa), FASTA scores: opt: 321, E(): 4.3e-13, (27.3% identity in 271 aa overlap); etc. TBparse score is 0.902.; integral membrane protein	complement(3721731..3722600)	Mycobacterium tuberculosis H37Rv	888029
NP_217853.1	CDS	trpS	NC_000962.2	3722621	3723631	R	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase	complement(3722621..3723631)	Mycobacterium tuberculosis H37Rv	887559
NP_217854.2	CDS	Rv3337	NC_000962.2	3723656	3724042	D	Rv3337, (MTV016.37), len: 128 aa. Conserved hypothetical protein, equivalent to N-terminus of Q49926|ML0685 TPEA (PUTATIVE HYDROLASE) from Mycobacterium leprae (303 aa), FASTA scores: opt: 362, E(): 5.7e-17, (74.3% identity in 70 aa overlap). Also weak similarity in N-terminus to Q98JT7|BAB49078|MLR1789 PROBABLE EPOXIDE HYDROLASE from Rhizobium loti (Mesorhizobium loti) (300 aa), FASTA scores: opt: 122, E(): 0.74, (31.95% identity in 97 aa overlap). Homology suggests this ORF should be in frame with the following ORF MTV016.38 but no sequence error could be found. Short distance to start of trpS suggests region may not be protein-coding. TBparse score is 0.941. C-terminus extended since first submission (+47 aa).; hypothetical protein	3723656..3724042	Mycobacterium tuberculosis H37Rv	887556
NP_217855.1	CDS	Rv3338	NC_000962.2	3723904	3724548	D	Rv3338, (MTV016.38), len: 214 aa. Hypothetical protein, equivalent to C-termini of Q49926|ML0685 TPEA (PUTATIVE HYDROLASE) from Mycobacterium leprae (303 aa), FASTA scores: opt: 984, E(): 2.6e-56, (65.4% identity in 214 aa overlap); and O32873|MLCB1779.02 HYPOTHETICAL 31.8 KDA PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Mycobacterium leprae (292 aa), FASTA scores: opt: 984, E(): 2.5e-56, (65.4% identity in 214 aa overlap). Also similar to C-termini of several hypothetical proteins (generally hydrolases) e.g. Q9K3H6|2SCG18.11 PUTATIVE HYDROLASE from Streptomyces coelicolor (316 aa), FASTA scores: opt: 213, E(): 1.4e-06, (29.75% identity in 185 aa overlap). Homology suggests that this ORF should be in frame with the previous ORF MTV016.37 but no sequence error could be found. TBparse score is 0.887.; hypothetical protein	3723904..3724548	Mycobacterium tuberculosis H37Rv	888020
NP_217856.1	CDS	icd1	NC_000962.2	3724615	3725844	R	Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase	complement(3724615..3725844)	Mycobacterium tuberculosis H37Rv	888013
NP_217857.1	CDS	metC	NC_000962.2	3726127	3727476	D	catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase	3726127..3727476	Mycobacterium tuberculosis H37Rv	888037
NP_217858.1	CDS	metX	NC_000962.2	3727488	3728627	D	Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase	3727488..3728627	Mycobacterium tuberculosis H37Rv	888030
NP_217859.1	CDS	Rv3342	NC_000962.2	3728624	3729355	D	Rv3342, (MTV016.42), len: 243 aa. Possible methyltransferase (EC 2.1.1.-), similar to various proteins e.g. Q9I5X8|PA0558 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (255 aa), FASTA scores: opt: 496, E(): 4.4e-24, (39.85% identity in 236 aa overlap); Q9XBC9|CZA382.22c PUTATIVE RRNA METHYLASE from Amycolatopsis orientalis (259 aa), FASTA scores: opt: 473, E(): 1.2e-22, (42.45% identity in 245 aa overlap); Q9UTA8|SPAC25B8.10 PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (256 aa), FASTA scores: opt: 470, E(): 1.9e-22, (35.7% identity in 238 aa overlap); and Q9UTA9|SPAC25B8.09 PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (251 aa), FASTA scores: opt: 418, E(): 3.4e-19, (31.2% identity in 237 aa overlap); etc. Start uncertain. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY. TBparse score is 0.878.; methyltransferase (methylase)	3728624..3729355	Mycobacterium tuberculosis H37Rv	888046
YP_177960.1	CDS	PPE54	NC_000962.2	3729364	3736935	R	Rv3343c, (MTV016.43c), len: 2523 aa. Member of the Mycobacterium tuberculosis PPE family, MPTR subgroup of Gly-, Asn-rich proteins. Most similar to O50379|Rv3350c|MTV004.07c|MTV004_5 from Mycobacterium tuberculosis strain H37Rv (3716 aa), FASTA scores: opt: 4672, E(): 4e-211, (44.2% identity in 3174 aa overlap); and also similar to MTV004_3, MTCY63_9, MTY13E10_17, MTY13E10_16, MTCY180_1, MTV050_1, MTCY3C7_23, MTV014_3, MTCY63_10; etc. TBparse score is 0.923.; PPE family protein	complement(3729364..3736935)	Mycobacterium tuberculosis H37Rv	888033
YP_177961.1	CDS	PE_PGRS49	NC_000962.2	3736984	>3738438	R	Rv3344c, (MTV016.44c), len: 484 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-, ala-rich proteins (see citation below). Appears to be a gene fragment, should be in-frame with following ORF, MTV016.45c, frameshift required around 49595 but could not be found on checking BAC and cosmid clones. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53557|Rv3512|MTV023.19 (1079 aa), FASTA scores: opt: 1595, E(): 1.8e-54, (52.0% identity in 544 aa overlap). TBparse score is 0.831.; PE-PGRS family protein	complement(3736984..>3738438)	Mycobacterium tuberculosis H37Rv	888115
YP_177962.1	CDS	PE_PGRS50	NC_000962.2	3738158	3742774	R	Rv3345c, (MTV004.01c-MTV016.45c), 1538 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Similar to AAK47791 from strain CDC1551 but with some big gaps (after residues 501 and 1419; and for AAK47791 after residue 991). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 4508, E(): 7e-161, (52.1% identity in 1529 aa overlap); MTV004_1, MTV023_21, MTV023_15, MTCY493_4, MTV039_16, MTV008_46, MTV023_14, MTV023_19, MTV043_26, MTCY493_2, MTCY441_4; etc.; PE-PGRS family protein	complement(3738158..3742774)	Mycobacterium tuberculosis H37Rv	888114
NP_217863.1	CDS	Rv3346c	NC_000962.2	3743198	3743455	R	Rv3346c, (MTV004.02c), len: 85 aa. Conserved hypothetical protein, highly similar to mycobacterium hypothetical proteins O50384|Rv3355c|MTV004.12c from strain H37Rv (97 aa), FASTA scores: opt: 413, E(): 4.6e-23, (85.55% identity in 97 aa overlap); O32878|MLCB1779.16c|ML0675 from Mycobacterium leprae (91 aa), FASTA scores: opt: 349, E(): 1.7e-18, (67.35% identity in 95 aa overlap).; hypothetical protein	complement(3743198..3743455)	Mycobacterium tuberculosis H37Rv	888010
YP_177963.1	CDS	PPE55	NC_000962.2	3743711	3753184	R	Rv3347c, (MTV004.03c), len: 3157 aa. Member of the Mycobacterium tuberculosis PPE family, Gly-, Ala-, Asn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551, e.g. O50379|Rv3350c|MTV004.07c (3716 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); and other upstream ORFs MTV004_5, MTY13E10_15, MTCY28_16, MTCY63_9, MTY13E10_17, MTCY180_1; etc.; PPE family protein	complement(3743711..3753184)	Mycobacterium tuberculosis H37Rv	888120
NP_217865.1	CDS	Rv3348	NC_000962.2	3753765	3754256	D	Rv3348, (MTV004.04), len: 163 aa. Probable transposase, partially similar to several insertion elements e.g. P19834|YI11_STRCL INSERTION ELEMENT IS116 HYPOTHETICAL 44.8 KDA PROTEIN (SIMILAR TO IS900 OF MYCOBACTERIUM PARATUBERCULOSIS) from Streptomyces clavuligerus (399 aa), FASTA scores: opt: 146, E(): 0.016, (29.1% identity in 158 aa overlap).; transposase	3753765..3754256	Mycobacterium tuberculosis H37Rv	888110
NP_217866.1	CDS	Rv3349c	NC_000962.2	3754293	3755033	R	Rv3349c, (MTV004.05c), len: 246 aa. Probable transposase pseudogene fragment, similar to part of Q50911|U10634 IS204 PUTATIVE TRANSPOSASE from NOCARDIA ASTEROIDES (377 aa), FASTA scores: opt: 288, E(): 8.3e-11, (48.5% identity in 97 aa overlap); and others.; transposase	complement(3754293..3755033)	Mycobacterium tuberculosis H37Rv	888126
YP_177964.1	CDS	PPE56	NC_000962.2	3755952	3767102	R	Rv3350c, (MTV004.07c), len: 3716 aa. Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-, Asn-rich proteins, similar to many Mycobacterium tuberculosis proteins from strains H37Rv and CDC1551, e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10, MTCY180_1, MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc.; PPE family protein	complement(3755952..3767102)	Mycobacterium tuberculosis H37Rv	888113
NP_217868.1	CDS	Rv3351c	NC_000962.2	3767346	3768140	R	Rv3351c, (MTV004.08c), len: 264 aa. Hypothetical protein, highly similar to C-terminal region (aa 292-479) of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE from Mycobacterium tuberculosis (479 aa), FASTA scores: opt: 699, E(): 1.7e-36, (54.75% identity in 190 aa overlap). Shows some similarity to Q9KYD6|SCD72A.20 PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (403 aa), FASTA scores: opt: 192, E(): 9.1e-05, (27.9% identity in 154 aa overlap); and P71091|YGAK HYPOTHETICAL 54.4 KDA PROTEIN from Bacillus subtilis (480 aa), FASTA scores: opt: 174, E(): 0.0014, (26.5% identity in 166 aa overlap). Note that the two upstream ORFs Rv3352c and Rv3353c also show similarity to Rv0063 (MTV030_7). Sequence was checked but no errors found.; hypothetical protein	complement(3767346..3768140)	Mycobacterium tuberculosis H37Rv	888109
NP_217869.1	CDS	Rv3352c	NC_000962.2	3768222	3768593	R	Rv3352c, (MTV004.09c), len: 123 aa. Possible oxidoreductase (EC 1.-.-.-), similar to part of several oxidoreductases (and hypothetical proteins) from diverse organisms e.g. Q9KYD6|SCD72A.20 PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (403 aa), FASTA scores: opt: 348, E(): 7.9e-15, (51.0% identity in 102 aa overlap); BAB53081|MLR6875 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (479 aa), FASTA scores: opt: 262, E(): 2.3e-09, (53.85% identity in 78 aa overlap); O94206|OX1 OXIDOREDUCTASE from Claviceps purpurea (Ergot fungus) (483 aa), FASTA scores: opt: 245, E(): 2.7e-08, (42.6% identity in 115 aa overlap); Q9KHK2|ENCM PUTATIVE FAD-DEPENDENT OXYGENASE ENCM from Streptomyces maritimus (464 aa), FASTA scores: opt: 238, E(): 7.2e-08, (43.95% identity in 91 aa overlap); etc. Also highly similar to part of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE (479 aa), FASTA scores: opt: 599, E(): 1.6e-30, (71.55% identity in 123 aa overlap); and to other Mycobacterium tuberculosis proteins e.g. Rv3353c and Rv3351c. All show similarity to a family of oxidoreductases in Mycobacterium tuberculosis, suggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found.; oxidoreductase	complement(3768222..3768593)	Mycobacterium tuberculosis H37Rv	888104
NP_217870.2	CDS	Rv3353c	NC_000962.2	3768736	3768996	R	Rv3353c, (MTV004.10c), len: 86 aa. Hypothetical protein, showing some similarity to Q9X5Q4|MITR MITR PROTEIN from Streptomyces lavendulae (514 aa), FASTA scores: opt: 134, E(): 0.09, (29.5% identity in 78 aa overlap); and weak to Q49720|B1549_C3_218 from Mycobacterium leprae (222 aa), FASTA scores: opt: 99, E(): 8.8, (32.9% identity in 76 aa overlap). But highly similar to N-terminal part of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE from Mycobacterium tuberculosis (479 aa), FASTA scores: opt: 305, E(): 4.9e-13, (52.9% identity in 87 aa overlap); and some similarity can be found with Rv3352c and Rv3351c. All show similarity to a family of oxidoreductases in Mycobacterium tuberculosis, suggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found. Start changed since original submission.; hypothetical protein	complement(3768736..3768996)	Mycobacterium tuberculosis H37Rv	888095
NP_217871.1	CDS	Rv3354	NC_000962.2	3769111	3769500	D	Rv3354, (MTV004.11), len: 129 aa. Conserved hypothetical protein, equivalent (but shorter 29 aa) to Q9CCM4|ML0676 HYPOTHETICAL PROTEIN from Mycobacterium leprae (158 aa), FASTA scores: opt: 467, E(): 3.3e-21, (55.9% identity in 127 aa overlaps). Highly similar to O33192|LPRJ|Rv1690|MTCI125.12 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (127 aa), FASTA scores: opt: 329, E(): 4.7e-13, (46.95% identity in 115 aa overlap); and also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O07222|Rv1810|MTCY16F9.04c (118 aa), FASTA scores: opt: 195, E(): 4.2e-05, (37.15% identity in 113 aa overlap); MTCI125_11, MTCY16F9_4, MTV049_25.; hypothetical protein	3769111..3769500	Mycobacterium tuberculosis H37Rv	887643
NP_217872.1	CDS	Rv3355c	NC_000962.2	3769514	3769807	R	Rv3355c, (MTV004.12c), len: 97 aa. Hypothetical protein, equivalent to O32878|MLCB1779.16c|ML0675 HYPOTHETICAL 9.6 KDA PROTEIN from Mycobacterium leprae (91 aa), FASTA scores: opt: 439, E(): 3.9e-23, (78.9% identity in 90 aa overlap). Identical, but with a gap, to O50377|Rv3346c|MTV004.02c HYPOTHETICAL 8.9 KDA PROTEIN from Mycobacterium tuberculosis (85 aa), FASTA scores: opt: 413, E(): 2.1e-21, (85.55% identity in 97 aa overlap). Also some similarity to other proteins e.g. Q9K3J5|SC2A6.10 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (178 aa), FASTA scores: opt: 147, E(): 0.003, (31.25% identity in 80 aa overlap).; hypothetical protein	complement(3769514..3769807)	Mycobacterium tuberculosis H37Rv	887660
NP_217873.1	CDS	folD	NC_000962.2	3769804	3770649	R	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase	complement(3769804..3770649)	Mycobacterium tuberculosis H37Rv	888145
NP_217874.1	CDS	Rv3357	NC_000962.2	3770773	3771048	D	Rv3357, (MTV004.14), len: 91 aa. Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. Q9Z4V7|YU1E_STRCO (alias CAC37261|SCBAC17D6.02) ORFU1E (BELONGS TO THE PHD/YEFM FAMILY) from Streptomyces coelicolor (87 aa), FASTA scores: opt: 344, E(): 1.9e-17, (62.05% identity in 87 aa overlap); P46147|YEFM_ECOLI|B2017 from Escherichia coli strain K12 (83 aa), FASTA scores: opt: 215, E(): 1.6e-08, (50.0% identity in 72 aa overlap); BAB58570|SAV2408 from Staphylococcus aureus subsp. aureus Mu50 (83 aa), FASTA scores: opt: 161, E(): 8.8e-05, (39.95% identity in 77 aa overlap); Q9Z5W8 PUTATIVE PHD PROTEIN from Francisella novicid (85 aa), FASTA scores: opt: 143, E(): 0.0016, (28.9% identity in 83 aa overlap); etc. Also similar to Rv1247c|MTV006.19c (89 aa) (36.9% identity in 84 aa overlap). SEEMS TO BELONG TO THE PHD/YEFM FAMILY.; hypothetical protein	3770773..3771048	Mycobacterium tuberculosis H37Rv	888135
NP_217875.1	CDS	Rv3358	NC_000962.2	3771045	3771302	D	Rv3358, (MTV004.15), len: 85 aa. Conserved hypohetical protein, highly similar to other hypohetical proteins e.g. Q9Z4V8|SCBAC17D6.03 from Streptomyces coelicolor (84 aa), FASTA scores: opt: 393, E(): 1.1e-21, (59.75% identity in 82 aa overlap); P56605|YOEB_ECOLI from Escherichia coli (84 aa), FASTA scores: opt: 305, E(): 2.2e-15, (49.35% identity in 77 aa overlap); Q9Z5W7 PUTATIVE DOC PROTEIN from Francisella novicida (68 aa), FASTA scores: opt: 253, E(): 9.6e-12, (51.6% identity in 62 aa overlap); BAB58569|SAV2407 from Staphylococcus aureus subsp. aureus Mu50 (88 aa), FASTA scores: opt: 250, E(): 2e-11, (40.5% identity in 84 aa overlap); etc.; hypothetical protein	3771045..3771302	Mycobacterium tuberculosis H37Rv	888139
NP_217876.1	CDS	Rv3359	NC_000962.2	3771344	3772534	D	Rv3359, (MTV004.16), len: 396 aa. Possible oxidoreductase (EC 1.-.-.-), similar to N-terminal part of various proteins (hypothetical unknowns or oxidoreductases) e.g. Q9ZB94 HYPOTHETICAL 69.3 KDA PROTEIN from Rhodococcus erythropolis (649 aa), FASTA scores: opt: 509, E(): 3e-24, (30.0% identity in 380 aa overlap); O29991|AF0248 NADH-DEPENDENT FLAVIN OXIDOREDUCTASE from Archaeoglobus fulgidus (378 aa), FASTA scores: opt: 478, E(): 1.6e-22, (32.45% identity in 379 aa overlap); Q9HUH9|PA4986 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (648 aa), FASTA scores: opt: 412, E(): 3.3e-18, (30.45% identity in 384 aa overlap); Q9KCT8|BH1481 NADH OXIDASE from Bacillus halodurans (338 aa), FASTA scores: opt: 404, E(): 6.1e-18, (30.2% identity in 275 aa overlap); etc. Some weak similarity to Mycobacterium leprae MLCB1779_10.; oxidoreductase	3771344..3772534	Mycobacterium tuberculosis H37Rv	887668
NP_217877.1	CDS	Rv3360	NC_000962.2	3772651	3773019	D	Rv3360, (MTV004.17), len: 122 aa. Hypothetical protein, highly similar to the N-terminus of O65934|Rv1747|MTCY28.10|MTCY04C12.31 probable ABC-transporter ATP-binding protein from Mycobacterium tuberculosis (865 aa), FASTA scores: opt: 480, E(): 4.7e-25, (61.0% identity in 118 aa overlap); and some similarity with the N-terminus of P96214|Rv3863|MTCY01A6.05c HYPOTHETICAL 41.1 KDA PROTEIN from Mycobacterium tuberculosis (392 aa), FASTA scores: opt: 138, E(): 0.033, (31.95% identity in 97 aa overlap). Some weak similarity with the N-terminus of other hypothetical proteins e.g. P73823|CYAA|SLR1991 ADENYLATE CYCLASE from Synechocystis sp. strain PCC 6803 (337 aa), FASTA scores: opt: 127, E(): 0.16, (28.55% identity in 112 aa overlap).; hypothetical protein	3772651..3773019	Mycobacterium tuberculosis H37Rv	888136
NP_217878.1	CDS	Rv3361c	NC_000962.2	3773016	3773567	R	Rv3361c, (MTV004.18c), len: 183 aa. Conserved hypothetical protein, with some similarity to various proteins e.g. P74221|YB52_SYNY3|SLR1152 HYPOTHETICAL 36.2 KDA PROTEIN SLR (CONTAINS 5 PENTAPEPTIDE REPEAT DOMAINS) from Synechocystis sp. strain PCC 6803 (331 aa), FASTA scores: opt: 252, E(): 3.9e-10, (30.55% identity in 167 aa overlap); Q9SE95 FH PROTEIN INTERACTING PROTEIN FIP2 from Arabidopsis thaliana (Mouse-ear cress) (298 aa), FASTA scores: opt: 207, E(): 4.4e-07, (30.35% identity in 168 aa overlap); Q9A735|CC1891 PENTAPEPTIDE REPEAT FAMILY PROTEIN from Caulobacter crescentus (250 aa), FASTA scores: opt: 181, E(): 2.3e-05, (24.05% identity in 187 aa overlap); etc.; hypothetical protein	complement(3773016..3773567)	Mycobacterium tuberculosis H37Rv	888130
NP_217879.1	CDS	Rv3362c	NC_000962.2	3773574	3774155	R	Rv3362c, (MTV004.19c), len: 193 aa. Probable ATP/GTP-binding protein, similar to others from Streptomyces coelicolor e.g. O86519|SC1C2.18c (174 aa), FASTA scores: opt: 731, E(): 9.8e-41, (66.85% identity in 169 aa overlap); Q9XAE1|SC6G9.41c (191 aa), FASTA scores: opt: 730, E(): 1.2e-40, (63.55% identity in 173 aa overlap); Q9L235|SC1A2.06 (184 aa), FASTA scores: opt: 650, E(): 1.9e-35, (55.95% identity in 177 aa overlap); Q9RJ74|SCI41.10c (176 aa), FASTA scores: opt: 618, E(): 2.3e-33, (55.9% identity in 161 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; ATP/GTP-binding protein	complement(3773574..3774155)	Mycobacterium tuberculosis H37Rv	888088
NP_217880.1	CDS	Rv3363c	NC_000962.2	3774136	3774504	R	Rv3363c, (MTV004.20c), len: 122 aa. Conserved hypothetical protein, similar to others from Streptomyces coelicolor e.g. O86523|SC1C2.23c (132 aa), FASTA scores: opt: 236, E(): 9e-09, (38.5% identity in 122 aa overlap); O86520|SC1C2.19c (190 aa), FASTA scores: opt: 231, E(): 2.7e-08, (41.0% identity in 122 aa overlap); Q9X834|SC9B1.14c (119 aa), FASTA scores: opt: 188, E(): 1.1e-05, (37.5% identity in 120 aa overlap); Q9ADJ4|SCBAC14E8.05 (113 aa), FASTA scores: opt: 167, E(): 0.00025, (33.05% identity in 109 aa overlap); etc.; hypothetical protein	complement(3774136..3774504)	Mycobacterium tuberculosis H37Rv	888090
NP_217881.1	CDS	Rv3364c	NC_000962.2	3774482	3774874	R	Rv3364c, (MTV004.21c), len: 130 aa. Conserved hypothetical protein, highly similar to others from Streptomyces coelicolor e.g. O86524|SC1C2.24c (137 aa), FASTA scores: opt: 466, E(): 1.3e-22, (58.6% identity in 116 aa overlap); O86521|SC1C2.20c (140 aa), FASTA scores: opt: 445, E(): 2.7e-21, (56.9% identity in 116 aa overlap); Q9KZI6|SCG8A.13c (145 aa), FASTA scores: opt: 341, E(): 9.5e-15, (51.3% identity in 113 aa overlap); etc.; hypothetical protein	complement(3774482..3774874)	Mycobacterium tuberculosis H37Rv	888085
NP_217882.1	CDS	Rv3365c	NC_000962.2	3774871	3777501	R	Rv3365c, (MTV004.22c), len: 876 aa. Conserved hypothetical protein, similar to various proteins from Streptomyces coelicolor e.g. O86525|SC1C2.25c HYPOTHETICAL 139.7 KDA PROTEIN (SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES) (1329 aa), FASTA scores: opt: 879, E(): 5.4e-32, (29.9% identity in 924 aa overlap) (similarity in N-terminal part for this one); O86522|SC1C2.21c HYPOTHETICAL 119.9 KDA PROTEIN (SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES) (1111 aa), FASTA scores: opt: 855, E(): 5.6e-31, (28.9% identity in 892 aa overlap) (similarity in N-terminal part for this one); Q9KZI5|SCG8A.14c PUTATIVE MEMBRANE PROTEIN (862 aa), FASTA scores: opt: 791, E(): 3.3e-28, (30.8% identity in 828 aa overlap); Q9KZN0|SC1A8A.22c (943 aa), FASTA scores: opt: 660, E(): 2.5e-22, (27.65% identity in 893 aa overlap); etc. Similar in part to two consecutive Mycobacterium leprae hypothetical ORFs, probably representing a pseudogene: O07701|MLCL383.27 (118 aa), FASTA scores: opt: 430, E(): 1e-12, (58.25% identity in 115 aa overlap); and O07700|MLCL383.26 (111 aa), FASTA scores: opt: 271, E(): 1.3e-05, (50.4% identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.; hypothetical protein	complement(3774871..3777501)	Mycobacterium tuberculosis H37Rv	887652
NP_217883.1	CDS	spoU	NC_000962.2	3777737	3778201	D	Rv3366, (MTV004.23), len: 154 aa. Probable spoU, tRNA/rRNA methylase (EC 2.1.1.-), equivalent to Q9CCU7|ML0419 PUTATIVE tRNA/rRNA METHYLTRANSFERASE from Mycobacterium leprae (158 aa), FASTA scores: opt: 861, E(): 1.2e-50, (83.75% identity in 154 aa overlap); and O07698|MLCL383.24c rRNA METHYLASE from Mycobacterium leprae (169 aa), FASTA scores: opt: 861, E(): 1.3e-50, (83.75% identity in 154 aa overlap). Also highly similar to many members of the spoU family of rRNA methylases e.g. Q9K199|NMB0268 RNA METHYLTRANSFERASE (TRMH FAMILY) from Neisseria meningitidis (serogroup B) (154 aa), FASTA scores: opt: 534, E(): 7.6e-29, (50.0% identity in 154 aa overlap); and Q9JSM8|NMA2218 from Neisseria meningitidis (serogroup A) (154 aa), FASTA scores: opt: 526, E(): 2.6e-28, (49.35% identity in 154 aa overlap); Q9HU57|PA5127 from Pseudomonas aeruginosa (153 aa), FASTA scores: opt: 531, E(): 1.2e-28, (52.95% identity in 151 aa overlap); P33899|YIBK_ECOLI|B3606 from Escherichia coli strain K12 (157 aa), FASTA scores: opt: 511, E(): 2.6e-27, (49.35% identity in 154 aa overlap); etc. BELONGS TO THE RNA METHYLTRANSFERASE TRMH FAMILY.; tRNA/rRNA methylase SpoU	3777737..3778201	Mycobacterium tuberculosis H37Rv	887648
YP_177965.1	CDS	PE_PGRS51	NC_000962.2	3778568	3780334	D	Rv3367, (MTV004.25), len: 588 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50415|Rv3388|MTV004.46 (731 aa), FASTA scores: opt: 1999, E(): 7.2e-72, (55.0% identity in 620 aa overlap); and MTV004_44, MTV043_65, MTV006_15, MTCY63_2, MTCY21B4_13, MTV023_21, MTV008_43, MTCY24A1_4, MTV023_15; etc. Equivalent to AAK47814 from Mycobacterium tuberculosis strain CDC1551 (628 aa) but shorter 37 aa.; PE-PGRS family protein	3778568..3780334	Mycobacterium tuberculosis H37Rv	887404
NP_217885.1	CDS	Rv3368c	NC_000962.2	3780335	3780979	R	Rv3368c, (MTV004.26c), len: 214 aa. Possible oxidoreductase (EC 1.-.-.-), equivalent to O07697|MLCL383.23|ML0418 HYPOTHETICAL 23.6 KDA PROTEIN (PUTATIVE OXIDOREDUCTASE) from Mycobacterium leprae (210 aa), FASTA scores: opt: 1215, E(): 1.5e-74, (81.4% identity in 210 aa overlap). Also similar to O30106|AF0131 PUTATIVE NAD(P)H-FLAVIN OXIDOREDUCTASE from Archaeoglobus fulgidus (194 aa), FASTA scores: opt: 139, E(): 0.028, (29.0% identity in 207 aa overlap); Q60049|NOX_THETH NADH DEHYDROGENASE from Thermus aquaticus (subsp. thermophilus) (205 aa), FASTA scores: opt: 169, E(): 0.00028, (28.3% identity in 212 aa overlap); and shows some similarity to other hypothetical proteins (unknowns or oxidoreductases).; oxidoreductase	complement(3780335..3780979)	Mycobacterium tuberculosis H37Rv	887641
NP_217886.1	CDS	Rv3369	NC_000962.2	3780978	3781412	D	Rv3369, (MTV004.27), len: 144 aa. Conserved hypothetical protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c HYPOTHETICAL 14.7 KDA PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: opt: 174, E(): 6e-05, (67.55% identity in 37 aa overlap). Also some slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces coelicolor (153 aa), FASTA scores: opt: 125, E(): 0.13, (31.05% identity in 116 aa overlap).; hypothetical protein	3780978..3781412	Mycobacterium tuberculosis H37Rv	887669
NP_217887.2	CDS	dnaE2	NC_000962.2	3781501	3784776	R	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase	complement(3781501..3784776)	Mycobacterium tuberculosis H37Rv	887259
NP_217888.1	CDS	Rv3371	NC_000962.2	3784932	3786272	D	Rv3371, (MTV004.29), len: 446 aa. Hypothetical protein, similar to many Mycobacterium tuberculosis (strains H37Rv and CDC1551) hypothetical proteins e.g. O07035|YV30_MYCTU|Rv3130c|MTCY03A2.28|MTCY164.41c (463 aa), FASTA scores: opt: 556, E(): 7.7e-28, (44.95% identity in 447 aa overlap); MTY20B11_9, MTCY28_26, MTV013_8, MTCY21B4_43, MTCY493_29; etc. Also similar to O07692|MLCL383_9|MLCL383.18c HYPOTHETICAL 14.1 KDA PROTEIN from Mycobacterium leprae (129 aa), FASTA scores: opt: 293, E(): 1.3e-11, (47.85% identity in 117 aa overlap).; hypothetical protein	3784932..3786272	Mycobacterium tuberculosis H37Rv	888053
NP_217889.1	CDS	otsB2	NC_000962.2	3786314	3787489	D	Rv3372, (MTV004.30),len: 391 aa. Possible otsB2, trehalose-6-phosphate phosphatase (EC 3.1.3.12), equivalent to Q49734|OTSB2|OTSP|B1620_F1_1|MLCL383.17c PUTATIVE TREHALOSE-PHOSPHATASE from Mycobacterium leprae (429 aa), FASTA scores: opt: 1675, E(): 2.4e-91, (67.05% identity in 425 aa overlap). Also weakly similar to several trehalose phosphatases e.g. Q9C8B3|F10O5.8 from Arabidopsis thaliana (Mouse-ear cress) (366 aa), FASTA scores: opt: 432, E(): 3.1e-18, (36.65% identity in 281 aa overlap); O27788|MTH1760 from Methanobacterium thermoautotrophicum (264 aa), FASTA scores: opt: 347, E(): 2.5e-13, (30.75% identity in 221 aa overlap); Q9FWQ2 from Oryza sativa (Rice) (382 aa), FASTA scores: opt: 338, E(): 1.1e-12, (32.5% identity in 320 aa overlap); etc. Also similar to part of Mycobacterium tuberculosis Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa), FASTA scores: opt: 1192, E(): 1.6e-62, (56.65% identity in 339 aa overlap).; trehalose 6-phosphate phosphatase	3786314..3787489	Mycobacterium tuberculosis H37Rv	888137
NP_217890.1	CDS	echA18	NC_000962.2	3787726	3788367	D	Rv3373, (MTV004.31), len: 213 aa. Probable echA18, enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 423, E(): 3.4e-20, (37.95% identity in 174 aa overlap); Q9X7Q4|SC5F2A.31c from Streptomyces coelicolor (257 aa), FASTA scores: opt: 399, E(): 1.2e-18, (45.05% identity in 171 aa overlap); BAB52005|MLL5584 from Rhizobium loti (Mesorhizobium loti) (257 aa), FASTA scores: opt: 385, E(): 9.6e-18, (41.95% identity in 174 aa overlap); etc. Also some similarity to 3-HYDROXYBUTYRYL-CoA DEHYDRATASES (EC 4.2.1.55) e.g. P52046|CRT_CLOAB from Clostridium acetobutylicum (261 aa), FASTA scores: opt: 414, E(): 1.3e-19, (38.3% identity in 175 aa overlap). And similar to other hydratases from Mycobacterium tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c PROBABLE ENOYL-CoA HYDRATASE (257 aa), FASTA scores: opt: 365, E(): 1.9e-16, (39.1% identity in 174 aa overlap). BELONGS TO THE ENOYL-CoA HYDRATASE/ISOMERASE FAMILY. Note that this homology extends across the stop codon and directly into the next ORF MTV004.29, suggesting a possible readthrough of the TGA stop codon.; enoyl-CoA hydratase	3787726..3788367	Mycobacterium tuberculosis H37Rv	888123
YP_177966.1	CDS	echA18.1	NC_000962.2	3788368	3788616	D	Rv3374, (MTV004.32), len: 82 aa. Probable echA18.1, enoyl-CoA hydratase C-terminus (EC 4.2.1.17), similar to the C-terminus of several enoyl-CoA hydratases e.g. Q9I5I4|PA0745 from Pseudomonas aeruginosa (272 aa), FASTA scores: opt: 123, E(): 0.13, (34.55% identity in 81 aa overlap); P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 115, E(): 0.45, (32.95% identity in 82 aa overlap); Q9I002|PA2841 from Pseudomonas aeruginosa (263 aa), FASTA scores: opt: 108, E(): 1.4, (30.95% identity in 84 aa overlap); etc. Also some similarity to C-terminus of O29956|AF0285 3-HYDROXYACYL-CoA DEHYDROGENASE from Archaeoglobus fulgidus (658 aa), FASTA scores: opt: 116, E(): 0.81, (34.15% identity in 82 aa overlap); and other enzymes. And similar to other hydratases from Mycobacterium tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c PROBABLE ENOYL-CoA HYDRATASE (257 aa), FASTA scores: opt: 111, E(): 0.83, (36.05% identity in 86 aa overlap). This homology extends across the upstream TGA stop codon into the upstream ORF MTV004.28, suggesting possible readthrough of the previous stop codon. Note that previously known as echA18'.; echA18'; enoyl-CoA hydratase	3788368..3788616	Mycobacterium tuberculosis H37Rv	888100
NP_217892.1	CDS	amiD	NC_000962.2	3788621	3790048	D	Rv3375, (MTV004.33), len: 475 aa. Probable amiD, amidase (EC 3.5.1.4), similar to various amidases e.g. Q53116|AMDA ENANTIOMERASE-SELECTIVE AMIDASE from Rhodococcus sp. (462 aa), FASTA scores: opt: 1036, E(): 1.6e-54, (38.6% identity in 464 aa overlap); Q9ZHK8|PZAA NICOTINAMIDASE/PYRAZINAMIDASE from Mycobacterium smegmatis (468 aa), FASTA scores: opt: 930, E(): 3.4e-48, (36.3% identity in 463 aa overlap); Q9A551|CC2613 PYRAZINAMIDASE/NICOTINAMIDASE from Caulobacter crescentus (464 aa), FASTA scores: opt: 841, E(): 7.1e-43, (39.45% identity in 469 aa overlap); O69768|AMID_PSEPU AMIDASE from Pseudomonas putida (466 aa), FASTA scores: opt: 800, E(): 2e-40, (33.6% identity in 467 aa overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE from Archaeoglobus fulgidu (453 aa), FASTA scores: opt: 669, E(): 1.3e-32, (30.4% identity in 467 aa overlap); etc. Also some similarity to AMIB2|Rv1263|MT1301|MTCY50.19c putative amidase from Mycobacterium tuberculosis (462 aa), (31.5% identity in 466 aa overlap). SEEMS BELONG TO THE AMIDASE FAMILY.; amidase AmiD	3788621..3790048	Mycobacterium tuberculosis H37Rv	888064
NP_217893.1	CDS	Rv3376	NC_000962.2	3790156	3790809	D	Rv3376, (MTV004.34), len: 217 aa. Hypothetical protein, similar to various bacterial proteins (notably hydrolases) e.g. Q9RUP0|DR1344 HYDROLASE from Deinococcus radiodurans (222 aa), FASTA scores: opt: 348, E(): 1.8e-15, (36.75% identity in 215 aa overlap); Q9RXA1|DR0414 HYDROLASE (CBBY/CBBZ/GPH/YIEH FAMILY) from Deinococcus radiodurans (155 aa), FASTA scores: opt: 233, E(): 3.5e-08, (36.4% identity in 151 aa overlap); Q9X0Q9|TM1177 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (225 aa), FASTA scores: opt: 231, E(): 6.6e-08, (27.6% identity in 221 aa overlap); Q9ABI3|CC0244 HYDROLASE, HALOACID DEHALOGENASE-LIKE from Caulobacter crescentus (213 aa), FASTA scores: opt: 213, E(): 9.1e-07, (28.95% identity in 221 aa overlap); BAB38231|ECS4808 PUTATIVE PHOSPHATASE from Escherichia coli strain O157:H7 (206 aa), FASTA scores: opt: 210, E(): 1.4e-06, (26.95% identity in 193 aa overlap); etc.; hypothetical protein	3790156..3790809	Mycobacterium tuberculosis H37Rv	888066
NP_217894.1	CDS	Rv3377c	NC_000962.2	3790848	3792353	R	Rv3377c, (MTV004.35c), len: 501 aa. Possible cyclase; similarity with various proteins, notably cyclases involved in steroid biosynthesis in plants and bacteria e.g. BAB52679|MLR6369 from Rhizobium loti (Mesorhizobium loti) (516 aa), FASTA scores: opt: 533, E(): 5.6e-27, (30.45% identity in 522 aa overlap); Q9ZTN8 COPALYL DIPHOSPHATE SYNTHASE 1 from Cucurbita maxima (Pumpkin) (Winter squash) (823 aa), FASTA scores: opt: 484, E(): 1.2e-23, (28.35% identity in 388 aa overlap); Q38710|AC22 ABIETADIENE CYCLASE from Abies grandis (868 aa), FASTA scores: opt: 382, E(): 5.2e-17, (25.55% identity in 462 aa overlap); Q41771|AN1 KAURENE SYNTHASE A from Zea mays (Maize) (823 aa), FASTA scores: opt: 377, E(): 1.1e-16, (29.75% identity in 390 aa overlap); Q9AJE4 DITERPENE CYCLASE-1 from Kitasatospora griseola (Streptomyces griseolosporeus) (499 aa), FASTA scores: opt: 336, E(): 3.2e-14, (27.5% identity in 513 aa overlap); Q9SAU6 E-ALPHA-BISABOLENE SYNTHASE (FRAGMENT) from Abies grandis (782 aa), FASTA scores: opt: 317, E(): 7.8e-13, (25.25% identity in 479 aa overlap); etc. Note that this and the upstream ORF MTV004.36c have a significantly lower GC bias than the rest of the genome.; cyclase	complement(3790848..3792353)	Mycobacterium tuberculosis H37Rv	888073
NP_217895.1	CDS	Rv3378c	NC_000962.2	3792358	3793248	R	Rv3378c, (MTV004.36c), len: 296 aa. Hypothetical unknown protein. Note that this ORF and the downstream ORF MTV004.35c have a significantly lower GC bias than the rest of the genome.; hypothetical protein	complement(3792358..3793248)	Mycobacterium tuberculosis H37Rv	888075
NP_217896.1	CDS	dxs2	NC_000962.2	3793257	3794867	R	Catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase	complement(3793257..3794867)	Mycobacterium tuberculosis H37Rv	888080
NP_217897.1	CDS	Rv3380c	NC_000962.2	3795100	3795984	R	Rv3380c, (MTV004.38c), len: 294 aa. Probable transposase (IS6110 ORF II), identical to many. May be expressed by frameshifting from the upstream ORF MTV004.39c.; transposase	complement(3795100..3795984)	Mycobacterium tuberculosis H37Rv	887411
NP_217898.1	CDS	Rv3381c	NC_000962.2	3796035	3796361	R	Rv3381c, (MTV004.39c), len: 108 aa. Probable transposase (IS6110 ORF I), identical to many.; transposase	complement(3796035..3796361)	Mycobacterium tuberculosis H37Rv	887646
YP_177967.1	CDS	lytB1	NC_000962.2	3796448	3797437	R	Rv3382c, (MTV004.40c), len: 329 aa. Probable lytB1, lytB-related protein, highly similar to many e.g. Q9HVM7|LYTB_PSEAE|PA4557 from Pseudomonas aeruginosa (314 aa), FASTA scores: opt: 1048, E(): 2e-55, (53.2% identity in 314 aa overlap); Q9JR39|LYTB|NMA0624|NMB1831 from Neisseria meningitidis (serogroup A and B) (322 aa), FASTA scores: opt: 1041, E(): 5.4e-55, (52.25% identity in 312 aa overlap); P22565|LYTB_ECOLI|B0029 from Escherichia coli strain K12 (316 aa), FASTA scores: opt: 1013, E(): 2.5e-53, (51.45% identity in 311 aa overlap) (for more information about lytB protein, see citation below); Q9X781|LYTB_MYCLE|LYTB2|ML1938|MLCB1222.06c from Mycobacterium leprae (332 aa), FASTA scores: opt: 979, E(): 2.8e-51, (51.3% identity in 312 aa overlap); etc. Also similar to Q9PAS9|XF2416 DRUG TOLERANCE PROTEIN from Xylella fastidiosa (316 aa), FASTA scores: opt: 1043, E(): 4.1e-55, (53.65% identity in 315 aa overlap). And similar to O53458|Rv1110|LYTB2|MTV017.63 from Mycobacterium tuberculosis (335 aa), FASTA scores: opt: 975, E(): 4.9e-51, (51.3% identity in 312 aa overlap). BELONGS TO THE LYTB FAMILY.; LYTB-like protein LYTB1	complement(3796448..3797437)	Mycobacterium tuberculosis H37Rv	887953
NP_217900.1	CDS	idsB	NC_000962.2	3797437	3798489	R	Rv3383c, (MTV004.41c), len: 350 aa. Possible idsB, polyprenyl transferase (polyprenyl diphosphate synthase) (EC 2.5.1.-), similar to many prenyltransferases involved in lipid biosynthesis e.g. Q9RGW1|GTR GERANYL TRANSFERASE from Streptomyces coelicolor (386 aa), FASTA scores: opt: 908, E(): 3.7e-50, (48.8/% identity in 334 aa overlap); Q9KWG0|GGDPS GERANYL GERANYL DIPHOSPHATE SYNTHASE from Kitasatospora griseola (Streptomyces griseolosporeus) (348 aa), FASTA scores: opt: 801, E(): 2e-43, (41.5% identity in 347 aa overlap); Q9X7V8|SC6A5.12 PUTATIVE POLYPRENYL SYNTHETASE from Streptomyces coelicolor (378 aa), FASTA scores: opt: 779, E(): 5.3e-42, (44.45% identity in 324 aa overlap); Q9S5E9 FARNESYL, GERANYLGERANYL, GERANYLFARNESYL, HEXAPRENYL, HEPTAPRENYL DIPHOSPHATE SYNTHASE (SELF-HEPPS) from Synechococcus elongatus (324 aa), FASTA scores: opt: 563, E(): 2.3e-28, (39.85% identity in 241 aa overlap) (see citation below); O26156|IDSA_METTH|MTH50 BIFUNCTIONAL SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE [INCLUDES: FARNESYL PYROPHOSPHATE SYNTHETASE (EC 2.5.1.1) (FPP SYNTHETASE) (DIMETHYLALLYLTRANSFERASE) AND GERANYLTRANSTRANSFERASE (EC 2.5.1.10)] from Methanobacterium thermoautotrophicum (325 aa), FASTA scores: opt: 540, E(): 6.5e-27, (35.75% identity in 319 aa overlap); P95999|GGPP_SULSO|GDS|GDS-1|SSO0061|C05010|C05_049 GERANYLGERANYL PYROPHOSPHATE SYNTHETASE (GGPP SYNTHETASE) (GGPS) [INCLUDES: DIMETHYLALLYLTRANSFERASE (EC 2.5.1.1)AND GERANYLTRANSTRANSFERASE (EC 2.5.1.10) AND FARNESYLTRANSTRANSFERASE (EC 2.5.1.29)] from Sulfolobus solfataricus (332 aa), FASTA scores: opt: 511, E(): 4.5e-25 (36.9% identity in 244 aa overlap); etc. Also similar to Q50727|GGPP_MYCTU|Rv3398c|MT3506|MTCY78.30 PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE [INCLUDES: DIMETHYLALLYLTRANSFERASE (EC 2.5.1.1); GERANYLTRANSTRANSFERASE (EC 2.5.1.10); FARNESYLTRANSTRANSFERASE (EC 2.5.1.29)] from Mycobacterium tuberculosis (359 aa), FASTA scores: opt: 687, E(): 3.4e-36, (39.1% identity in 325 aa overlap). Contains PS00723 Polyprenyl synthetases signature 1. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY.; polyprenyl synthetase IdsB	complement(3797437..3798489)	Mycobacterium tuberculosis H37Rv	887680
NP_217901.1	CDS	Rv3384c	NC_000962.2	3799243	3799635	R	Rv3384c, (MTV004.42c), len: 130 aa. Hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA scores: opt: 266, E(): 1.6e-10, (43.1% identity in 130 aa overlap); and Q50717|YY08_MYCTU|Rv3408|MTCY78.20c (136 aa), FASTA scores: opt: 243, E(): 4.8e-09, (35.1% identity in 131 aa overlap).; hypothetical protein	complement(3799243..3799635)	Mycobacterium tuberculosis H37Rv	887432
NP_217902.1	CDS	Rv3385c	NC_000962.2	3799635	3799943	R	Rv3385c, (MTV004.43c), len: 102 aa. Hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Q50718|Y09M_MYCTU|MTCY78.21c|Rv3407|MT3515 (99 aa), FASTA scores: opt: 155, E(): 0.001, (41.05% identity in 78 aa overlap); O07782|Rv0596c|MTCY19H5.26 (85 aa), FASTA scores: opt: 136, E(): 0.016, (39.45% identity in 71 aa overlap); P96916|Rv0626|MTCY20H10.07 (86 aa), FASTA scores: opt: 130, E(): 0.04, (51.2% identity in 41 aa overlap); etc. Also similar to PREVENT HOST DEATH (PHD) PROTEINS e.g. CAA66834|PHD from Escherichia coli (73 aa), FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa overlap); and Q06253|PHD_BPP1 from Bacteriophage P1 (73 aa), FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa overlap).; hypothetical protein	complement(3799635..3799943)	Mycobacterium tuberculosis H37Rv	887429
NP_217903.1	CDS	Rv3386	NC_000962.2	3800092	3800796	D	Rv3386, (MTV004.44), len: 234 aa. Possible transposase, showing very weak similarity to several IS element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis (112 aa), FASTA scores: opt: 507, E(): 8.3e-25, (83.9% identity in 87 aa overlap).; transposase	3800092..3800796	Mycobacterium tuberculosis H37Rv	888044
NP_217904.1	CDS	Rv3387	NC_000962.2	3800786	3801463	D	Rv3387, (MTV004.45), len: 225aa. Possible transposase, showing very weak similarity to other IS element proteins, and similar to various hypothetical proteins.; transposase	3800786..3801463	Mycobacterium tuberculosis H37Rv	887820
YP_177968.1	CDS	PE_PGRS52	NC_000962.2	3801653	3803848	D	Rv3388, (MTV004.46), len: 731 aa. Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to many PE-family proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53553|YZ08_MYCTU|RV3508|MTV023.15 (1901 aa), FASTA scores: opt: 2380, E(): 3.6e-87, (53.8% identity in 773 aa overlap); and MTV023_21, MTV023_18, MTV023_14, MTV039_16, MTCY441_4.; PE-PGRS family protein	3801653..3803848	Mycobacterium tuberculosis H37Rv	888151
NP_217906.1	CDS	Rv3389c	NC_000962.2	3803919	3804791	R	Rv3389c, (MTV004.47c), len: 290 aa. Possible dehydrogenase (EC 1.-.-.-), similar to parts of several bacterial dehydrogenases and eukaryotic short-chain dehydrogenases involved in steroid biosynthesis e.g. Q9UVH9|FOX2 FOX2 PROTEIN (a multifunctional protein of the peroxisomal beta-oxidation) (SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Glomus mosseae (1015 aa), FASTA scores: opt: 649, E(): 7.5e-33, (40.9% identity in 269 aa overlap); Q9L009|SCC30.12c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (333 aa), FASTA scores: opt: 602, E(): 2.7e-30, (40.35% identity in 305 aa overlap); AAH03098 HYDROXYSTEROID (17-BETA) DEHYDROGENASE 4 from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): 2.1e-29, (41.55% identity in 272 aa overlap); P51659|DHB4_HUMAN ESTRADIOL 17 BETA-DEHYDROGENASE 4 from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): 2.1e-29, (41.55% identity in 272 aa overlap); Q19058|E04F6.3 HYDRATASE-DEHYDROGENASE-EPIMERASE from Caenorhabditis elegans (298 aa), FASTA scores: opt: 573, E(): 1.6e-28, (41.0% identity in 266 aa overlap); O42484 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE IV from Gallus gallus (Chicken) (735 aa), FASTA scores: opt: 573, E(): 3.2e-28, (39.8% identity in 279 aa overlap); etc. And also similar in part to Q9LBK1|PHAJ2|PA1018 (R)-SPECIFIC ENOYL-CoA HYDRATASE from Pseudomonas aeruginosa (288 aa), FASTA scores: opt: 601, E(): 2.7e-30, (40.5% identity in 294 aa overlap). And similar to P71863|UFAA2|Rv3538|MTCY03C7.18c HYPOTHETICAL 30.2 KDA PROTEIN from Mycobacterium tuberculosis (286 aa), FASTA scores: opt: 609, E(): 8.7e-31, (39.65% identity in 285 aa overlap). HAS SOME SIMILARITY TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; dehydrogenase	complement(3803919..3804791)	Mycobacterium tuberculosis H37Rv	887923
NP_217907.1	CDS	lpqD	NC_000962.2	3804865	3805575	D	Rv3390, (MTV004.48), len: 236 aa. Probable lpqD, a conserved lipoprotein with some similarity to various bacterial proteins e.g. Q9F3Q7|SC10F4.03 PUTATIVE ISOMERASE from Streptomyces coelicolor (224 aa), FASTA scores: opt: 416, E(): 2.5e-18, (33.0% identity in 197 aa overlap); Q9ZAX0|PGM 2,3-PDG DEPENDENT PHOSPHOGLYCERATE MUTASE from Amycolatopsis methanolica (205 aa), FASTA scores: opt: 314, E(): 3.7e-12, (28.55% identity in 203 aa overlap); P73454|SLR1748 HYPOTHETICAL 24.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (214 aa), FASTA scores: opt: 201, E(): 2.8e-05, (23.8% identity in 189 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. O53817|Rv0754|MTV041.28 PGRS-FAMILY PROTEIN (584 aa), FASTA scores: opt: 219, E(): 5.1e-06, (39.8% identity in 226 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LpqD	3804865..3805575	Mycobacterium tuberculosis H37Rv	887627
NP_217908.1	CDS	acrA1	NC_000962.2	3805621	3807573	D	Rv3391, (MTV004.49), len: 650 aa. Possible acrA1, multi functional protein with fatty acyl-CoA reductase activity in C-terminal part (EC 1.2.1.-). Indeed C-terminal part highly similar to P94129|ACR1 FATTY ACYL-CoA REDUCTASE from Acinetobacter calcoaceticus (295 aa), FASTA scores: opt: 767, E(): 1.4e-36, (45.4% identity in 260 aa overlap); and similar to other oxidoreductases dehydrogenases/reductases e.g. Q9Y3A1 CGI-93 PROTEIN (SIMILARITY WITH SDR FAMILY) from Homo sapiens (Human) (291 aa), FASTA scores: opt: 363, E(): 1.5e-13, (38.65% identity in 194 aa overlap); Q9L146|SC6D11.09 PUTATIVE OXIDOREDUCTASE (SIMILARITY WITH SDR FAMILY) from Streptomyces coelicolor (343 aa), FASTA scores: opt: 346, E(): 1.6e-12, (30.4% identity in 283 aa overlap); Q9HSR4|YUSZ1|VNG0115G OXIDOREDUCTASE from Halobacterium sp. strain NRC-1 (260 aa), FASTA scores: opt: 338, E(): 3.7e-12, (33.85% identity in 248 aa overlap); etc. C-terminus also similar to Mycobacterium tuberculosis proteins Q10783|YF43_MYCTU|Rv1543|MTCY48.22c PUTATIVE OXIDOREDUCTASE (341 aa), FASTA scores: opt: 787, E(): 1.2e-37, (39.8% identity in 319 aa overlap); O06413|Rv0547c|MTCY25D10.26c HYPOTHETICAL 31.8 KDA PROTEIN (294 aa), FASTA scores: opt: 565, E(): 4.7e-25, (36.8% identity in 242 aa overlap); O53398|Rv1050|MTV017.03 OXIDOREDUCTASE (SDR FAMILY) (301 aa), FASTA scores: opt: 436, E(): 1.1e-17, (32.2% identity in 292 aa overlap). N-terminus (aa 1-320) is similar to P37693|HETM_ANASP polyketide synthase hetM from Anabaena sp. (506 aa), FASTA scores: opt: 188, E(): 1.3e-07, (27.7% identity in 361 aa overlap); so certainly a multi-domain enzyme. SEEMS TO BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Note that this ORF corresponds to the gene ORF2|Q11197 (see Yuan et al., 1995), but longer 266 aa, due to use of a more upstream start site.; short chain dehydrogenase	3805621..3807573	Mycobacterium tuberculosis H37Rv	887950
NP_217909.1	CDS	cmaA1	NC_000962.2	3807574	3808437	R	Rv3392c, (MTV004.50), len: 287 aa. cmaA1, cyclopropane mycolic acid synthase 1 (EC 2.1.1.79), characterized in 1995 as CFA1_MYCTU|Q11195|CMAA1|CMA1 cyclopropane-fatty-acyl-phospholipid synthase 1 (see citations below). Highly similar to Mycobacterium tuberculosis proteins MTCY20H10.23c (58.7% identity in 286 aa overlap); MTCY20H10.24c (68.6% identity); MTCY20H10.25c (73.5% identity); MTCY20H10.26c (57.0% identity); and MTCY20G9.30c (55.7% identity). Also highly similar to Q9CBK3|MMAA4|ML1903 METHYL MYCOLIC ACID SYNTHASES from Mycobacterium leprae (298 aa), FASTA scores: opt: 1098, E(): 1e-63, (57.0% identity in 286 aa overlap). Equivalent to AAK44898|MT0672 from Mycobacterium tuberculosis strain CDC1551 (317 aa) but shorter 30 aa and with some differences in residues between the proteins.; cyclopropane-fatty-acyl-phospholipid synthase 1	complement(3807574..3808437)	Mycobacterium tuberculosis H37Rv	887961
NP_217910.1	CDS	iunH	NC_000962.2	3808461	3809387	D	Rv3393, (MTV004.51), len: 308 aa. Probable iunH, nucleoside hydrolase (EC 3.2.2.-), similar to others e.g. Q9RXB2|DR0403 from Deinococcus radiodurans (314 aa), FASTA scores: opt: 497, E(): 6e-24, (34.3% identity in 312 aa overlap); Q27546|IUNH_CRIFA from Crithidia fasciculata (314 aa), FASTA scores: opt: 475, E(): 1.4e-22, (31.45% identity in 318 aa overlap); Q9CK67|IUNH from Pasteurella multocida (310 aa), FASTA scores: opt: 464, E(): 6.9e-22, (30.9% identity in 314 aa overlap); Q9A549|CC2615 from Caulobacter crescentus (323 aa), FASTA scores: opt: 464, E(): 7.2e-22, (37.85% identity in 280 aa overlap); etc. Note that also similar to BAB34113|ECS0690 (alias AAG54985|YBEK) PUTATIVE TRNA SYNTHETASE from Escherichia coli strain O157:H7 (311 aa), FASTA scores: opt: 483, E(): 4.5e-23, (33.0% identity in 315 aa overlap). The active site histidine is conserved.; nucleoside hydrolase IunH	3808461..3809387	Mycobacterium tuberculosis H37Rv	887625
NP_217911.1	CDS	Rv3394c	NC_000962.2	3809442	3811025	R	Rv3394c, (MTV004.52c), len: 527 aa. Hypothetical protein, with some similarity to various bacterial proteins e.g. BAB51085|MLR4427 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (545 aa), FASTA scores: opt: 267, E(): 2.8e-08, (26.5% identity in 509 aa overlap); BAB48362|MLR0866 DNA DAMAGE INDUCIBLE PROTEIN P from Rhizobium loti (Mesorhizobium loti) (438 aa), FASTA scores: opt: 245, E(): 4.6e-07, (25.5% identity in 290 aa overlap); Q9S292|SCI11.27c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (322 aa), FASTA scores: opt: 202, E(): 0.00012, (28.5% identity in 323 aa overlap); etc. Also similarity with P95102|DINP|RV3056|MTCY22D7.25c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (346 aa), FASTA scores: opt: 211, E(): 3.9e-05, (26.45% identity in 306 aa overlap). Equivalent to AAK47838 from Mycobacterium tuberculosis strain CDC1551 (492 aa) but longer 35 aa.; hypothetical protein	complement(3809442..3811025)	Mycobacterium tuberculosis H37Rv	887945
NP_217912.2	CDS	Rv3395c	NC_000962.2	3811022	3811636	R	Rv3395c, (MTCY78.33), len: 204 aa. Conserved hypothetical protein, with some similarity with RECA PROTEINS (RECOMBINASES A) e.g. P16238|RECA_THIFE from Thiobacillus ferrooxidans (346 aa), FASTA scores: opt: 131, E(): 1.1, (31.45% identity in 140 aa overlap); Q59560|RECA_MYCSM from Mycobacterium smegmatis (349 aa), FASTA scores: opt: 121, E(): 4.4, (30.25% identity in 129 aa overlap); etc. Note that shortened since first submission to avoid overlap with Rv3395A. Equivalent to AAK47839 from Mycobacterium tuberculosis strain CDC1551 (227 aa) but shorter 23 aa.; hypothetical protein	complement(3811022..3811636)	Mycobacterium tuberculosis H37Rv	887960
YP_177969.1	CDS	Rv3395A	NC_000962.2	3811719	3812345	D	Rv3395A, len: 208 aa. Probable membrane protein, with potential transmembrane stretches from aa 7..25 and 55..77. Weak similarity to Q9F2P3|SCE41.16C PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (258 aa), FASTA scores: opt: 107, E(): 7.4, (34.05% identity in 94 aa overlap).; hypothetical protein	3811719..3812345	Mycobacterium tuberculosis H37Rv	3205044
NP_217913.1	CDS	guaA	NC_000962.2	3812501	3814078	R	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase	complement(3812501..3814078)	Mycobacterium tuberculosis H37Rv	887412
NP_217914.1	CDS	phyA	NC_000962.2	3814090	3814998	R	Rv3397c, (MTCY78.31), len: 302 aa. Probable phyA (alternate gene name: crtB), phytoene synthase (EC 2.5.1.-), similar to many others e.g. Q9X7V5|SC6A5.09 from Streptomyces coelicolor (312 aa), FASTA scores: opt: 791, E(): 2.8e-43, (48.25% identity in 286 aa overlap); Q9RW07|DR0862 from Deinococcus radiodurans (325 aa), FASTA scores: opt: 482, E(): 1.5e-23, (35.25% identity in 292 aa overlap); Q9JRU9|NMB1168|NMB1130 from Neisseria meningitidis (serogroup B) (290 aa), FASTA scores: opt: 446, E(): 2.8e-21, (34.25% identity in 260 aa overlap); P37272|PSY_CAPAN from Capsicum annuum (Bell pepper) (419 aa), FASTA scores: opt: 431, E(): 3.4e-20, (33.0% identity in 288 aa overlap); etc. Also similar to Q9JUF5|NMA1339 PUTATIVE POLY-ISOPRENYL TRANSFERASE (EC 2.5.1.) from Neisseria meningitidis (serogroup A) (290 aa), FASTA scores: opt: 450, E(): 1.6e-21, (34.6% identity in 260 aa overlap). And similar to crtB|O05424 PHYTOENE SYNTHASE from Mycobacterium marinum (319 aa), BLASTP scores: 113, E= 6e-24, Identities = 89/283 (31%) (see citation below). Contains PS01045 Squalene and phytoene synthases signature 2. BELONGS TO THE PHYTOENE/SQUALENE SYNTHETASE FAMILY.; crtB; phytoene synthase	complement(3814090..3814998)	Mycobacterium tuberculosis H37Rv	887911
YP_177970.1	CDS	idsA1	NC_000962.2	3815027	3816106	R	Rv3398c, (MTCY78.30), len: 359 aa. Probable idsA1, geranylgeranyl pyrophosphate synthetase (GGPP synthetase) including: dimethylallyltransferase (EC 2.5.1.1), geranyltranstransferase (EC 2.5.1.10), and farnesyltranstransferase (EC 2.5.1.29). Most similar to AE000797_3|O26156|Q53479 bifunctional short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrop (325 aa), FASTA scores: opt: 605, E(): 0, (37.1% identity in 329 aa overlap); homology suggests ATG at 30121 or TTG at 30145 to be the initiation codon. Contains PS00444 Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY; BELONGS TO A FAMILY THAT GROUPS TOGETHER FPP SYNTHETASE, GGPP SYNTHETASE AND HEXAPRENYL PYROPHOSPHATE SYNTHETASE. Note that previously known as idsA.; idsA; multifunctional dimethylallyltransferase/farnesyl diphosphate synthetase/ farnesyltranstransferase	complement(3815027..3816106)	Mycobacterium tuberculosis H37Rv	887919
NP_217916.1	CDS	Rv3399	NC_000962.2	3816129	3817175	D	Rv3399, (MTCY78.29c), len: 348 aa. Hypothetical protein, similar to other Mycobacterium tuberculosis (strains H37Rv and CDC1551) hypothetical proteins e.g. P95074|Rv0726c|MTCY210.45c (367 aa), FASTA scores: opt: 1188, E(): 7.7e-69, (60.05% identity in 308 aa overlap); MTCY31.21c (38.0% identity in 308 aa overlap), MTV041_5, MTCY4C12_14, MTY13D12_21, MTV043_22, MTCY210_44, MTCI5_19, MTCI5_20, MTV035_9, MTCY180_22, MTCY31_23, MTY13D12_1, MTCY180_29; etc.; hypothetical protein	3816129..3817175	Mycobacterium tuberculosis H37Rv	887938
NP_217917.1	CDS	Rv3400	NC_000962.2	3817239	3818027	D	Rv3400, (MTCY78.28c), len: 262 aa. Probable hydrolase (EC 3.-.-.-), strongly equivalent to Q49741|YY00_MYCLE|ML0393|B1620_F3_119 HYPOTHETICAL 28.6 KDA PROTEIN from Mycobacterium leprae (261 aa), FASTA scores: opt: 1293, E(): 2.2e-71, (74.45% identity in 262 aa overlap). Similar to several various proteins (notably hydrolases) e.g. Q9L2I7|SCF42.32 PUTATIVE HYDROLASE from Streptomyces coelicolor (246 aa), FASTA scores: opt: 888, E(): 7.7e-47, (56.35% identity in 245 aa overlap); Q9EX06|2SCG38.13 PUTATIVE HYDROLASE from Streptomyces coelicolor (238 aa), FASTA scores: opt: 195, E(): 8.1e-05, (29.5% identity in 234 aa overlap); Q9I5X4|PA0562 PROBABLE HYDROLASE from Pseudomonas aeruginosa (224 aa), FASTA scores: opt: 190, E(): 0.00015, (27.8% identity in 248 aa overlap); O06995|PGMB_BACSU|YVDM PUTATIVE BETA-PHOSPHOGLUCOMUTASE from Bacillus subtilis (226 aa), FASTA scores: opt: 190, E(): 0.00016, (33.9% identity in 245 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa), FASTA scores: opt: 413, E(): 2e-17, (34.9% identity in 238 aa overlap). Interestingly, note that Rv3400 and Rv3401 are similar to beginning and end of Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 aa missing from the middle.; hydrolase	3817239..3818027	Mycobacterium tuberculosis H37Rv	887918
NP_217918.1	CDS	Rv3401	NC_000962.2	3818042	3820402	D	Rv3401, (MTCY78.27c), len: 786 aa. Hypothetical conserved protein, may be an hydrolase or a transferase, equivalent to Q49736|ML0392|B1620_F1_30 HYPOTHETICAL 88.1 KDA PROTEIN from Mycobacterium leprae (792 aa), FASTA scores: opt: 4820, E(): 0, (91.45% identity in 782 aa overlap). Also highly similar to Q9L2I8|SCF42.31c PUTATIVE GLYCOSYL TRANSFERASE from Streptomyces coelicolor (792 aa), FASTA scores: opt: 3060, E(): 2.9e-179, (59.25% identity in 785 aa overlap); and similar to others e.g. Q9K109|NMB0390 MALTOSE PHOSPHORYLASE from Neisseria meningitidis (serogroup B) (752 aa), FASTA scores: opt: 980, E(): 3.5e-52, (29.2% identity in 774 aa overlap); Q9JSW8|MAPA|NMA2098 PUTATIVE MALTOSE PHOSPHORYLASE (EC 2.4.1.8) from Neisseria meningitidis (serogroup A) (752 aa), FASTA scores: opt: 956, E(): 1e-50, (28.4% identity in 764 aa overlap); O06993|YVDK_BACSU HYPOTHETICAL 88.3 KDA PROTEIN (BELONGS TO FAMILY 65 OF GLYCOSYL HYDROLASES) from Bacillus subtilis (757 aa), FASTA scores: opt: 926, E(): 6.9e-49, (28.5% identity in 754 aa overlap); Q9CF04|MAPA MALTOSEPHOSPHORYLASE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (751 aa), FASTA scores: opt: 907, E(): 1e-47, (26.95% identity in 753 aa overlap); P77154|YCJT_ECOLI|B1316 HYPOTHETICAL 84.9 KDA PROTEIN (BELONGS TO FAMILY 65 OF GLYCOSYL HYDROLASES) from Escherichia coli strain K12 (755 aa), FASTA scores: opt: 392, E(): 2.9e-16, (27.5% identity in 774 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa), (27.2% identity in 802 aa overlap); note that Rv3400 and Rv3401 are similar to beginning and end of Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 aa missing from the middle.; hypothetical protein	3818042..3820402	Mycobacterium tuberculosis H37Rv	887928
NP_217919.1	CDS	Rv3402c	NC_000962.2	3820653	3821891	R	Rv3402c, (MTCY78.26), len: 412 aa. Conserved hypothetical protein, probably involved in cell process, similar to various proteins generally involved in extracellular compounds (lipopolysaccharide O-antigen) biosynthesis e.g. O68392|RFBE PEROSAMINE SYNTHETASE from Brucella melitensis (367 aa), FASTA scores: opt: 420, E(): 1.2e-19, (26.15% identity in 375 aa overlap); Q9L6C1 3,4-DEHYDRATASE-LIKE PROTEIN from Streptomyces antibioticus (393 aa), FASTA scores: opt: 419, E(): 1.5e-19, (30.65% identity in 385 aa overlap); Q9RR26|OLENI DEHYDRATASE from Streptomyces antibioticus (393 aa), FASTA scores: opt: 416, E(): 2.3e-19, (30.65% identity in 385 aa overlap); O33942 ERYCIV PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (401 aa), FASTA scores: opt: 410, E(): 5.6e-19, (31.75% identity in 362 aa overlap); Q9UZI4|ASPB-LIKE1|PAB0774 ASPARTATE AMINOTRANSFERASE (ASPB-LIKE1) from Pyrococcus abyssi (366 aa), FASTA scores: opt: 402, E(): 1.7e-18, (27.05% identity in 377 aa overlap); O88001|WLBC PUTATIVE AMINO-SUGAR BIOSYNTHESIS PROTEIN from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (366 aa), FASTA scores: opt: 394, E(): 5.6e-18, (26.8% identity in 347 aa overlap); Q45378|BPLC DNA FOR LIPOPOLYSACCHARIDE BIOSYNTHESIS from Bordetella pertussis (366 aa), FASTA scores: opt: 393, E(): 6.5e-18, (26.8% identity in 347 aa overlap); etc.; hypothetical protein	complement(3820653..3821891)	Mycobacterium tuberculosis H37Rv	887910
NP_217920.1	CDS	Rv3403c	NC_000962.2	3822262	3823863	R	Rv3403c, (MTCY78.25), len: 533 aa. Hypothetical unknown protein, but some weak similarity to Q9KJP2 HYPOTHETICAL 54.9 KDA PROTEIN from Myxococcus xanthus (504 aa), FASTA scores: opt: 157, E(): 0.011, (24.1% identity in 548 aa overlap).; hypothetical protein	complement(3822262..3823863)	Mycobacterium tuberculosis H37Rv	887907
NP_217921.1	CDS	Rv3404c	NC_000962.2	3823880	3824584	R	Rv3404c, (MTCY78.24), len: 234 aa. Conserved hypothetical protein, some similarity to several METHIONYL-TRNA FORMYLTRANSFERASES e.g. BAB51418|MLL4854 from Rhizobium loti (Mesorhizobium loti) (317 aa), FASTA scores: opt: 210, E(): 1.7e-06, (27.55% identity in 178 aa overlap); P94463|FMT_BACSU from Bacillus subtilis (317 aa), FASTA scores: opt: 199 ,E(): 8.8e-06, (28.25% identity in 177 aa overlap); O51091||FMT_BORBU|BB0064 from Borrelia burgdorferi (Lyme disease spirochete) (312 aa), FASTA scores: opt: 187, E(): 5.2e-05, (30.2% identity in 192 aa overlap); etc.; hypothetical protein	complement(3823880..3824584)	Mycobacterium tuberculosis H37Rv	887902
NP_217922.1	CDS	Rv3405c	NC_000962.2	3824702	3825268	R	Rv3405c, (MTCY78.23), len: 188 aa. Possible transcriptional regulator, showing weak similarity to other bacterial regulatory proteins e.g. Q9KE70|BH0987 from Bacillus halodurans (203 aa), FASTA scores: opt: 168, E(): 0.0016, (34.8% identity in 92 aa overlap); Q9A5F7|CC2493 Caulobacter crescentus (204 aa), FASTA scores: opt: 160, E(): 0.0051, (32.6% identity in 89 aa overlap); Q9RDR0|SC4A7.02 from Streptomyces coelicolor (227 aa), FASTA scores: opt: 159, E(): 0.0064, (37.0% identity in 189 aa overlap); etc. Also some similarity to hypothetical Mycobacterium tuberculosis regulatory proteins e.g. O05858|Rv3208|MTCY07D11.18c, MTCI125_6, MTCY7D11_18, MTCY10G2_30; etc. Contains potential helix-turn-helix motif from aa 39-60 (+2.97 SD).; transcriptional regulatory protein	complement(3824702..3825268)	Mycobacterium tuberculosis H37Rv	887940
NP_217923.1	CDS	Rv3406	NC_000962.2	3825330	3826217	D	Rv3406, (MTCY78.22c), len: 295 aa. Probable dioxygenase (EC 1.-.-.-), highly similar to Q9WWU|ATSK PUTATIVE ALPHA-KETOGLUTARATE DEPENDENT DIOXYGENASE from Pseudomonas putida (301 aa), FASTA scores: opt: 994, E(): 3.9e-57, (53.7% identity in 283 aa overlap); Q9I6U1|PA0193 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa), FASTA scores: opt: 1024, E(): 4.4e-59, (53.65% identity in 287 aa overlap); Q9HX81|TAUD|PA3935 TAURINE DIOXYGENASE from Pseudomonas aeruginosa (277 aa), FASTA scores: opt: 599, E(): 1.4e-31, (39.35% identity in 277 aa overlap); and similar to other dioxygenases e.g. AAG54718|TAUD (alias BAB33845|ECS0422) TAURINE DIOXYGENASE 2-OXOGLUTARATE-DEPENDENT from Escherichia coli strain O157:H7 (283 aa), FASTA scores: opt: 595, E(): 2.5e-31, (38.1% identity in 281 aa overlap); etc. BELONGS TO THE TFDA FAMILY OF DIOXYGENASES.; dioxygenase	3825330..3826217	Mycobacterium tuberculosis H37Rv	887955
NP_217924.1	CDS	Rv3407	NC_000962.2	3826252	3826551	D	Rv3407, (MTCY78.21c), len: 99 aa. Hypothetical protein, similar to other hypothetical proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK46285|MT2013 (90 aa), FASTA scores: opt: 160, E(): 0.00021, (37.1% identity in 89 aa overlap); O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: opt: 155, E(): 0.00051, (41.05% identity in 78 aa overlap), MTCY19H5.26, MTCY20H10.07, MTI376.09c, MTCY427.21, etc.; hypothetical protein	3826252..3826551	Mycobacterium tuberculosis H37Rv	887505
NP_217925.1	CDS	Rv3408	NC_000962.2	3826548	3826958	D	Rv3408, (MTCY78.20c), len: 136 aa. Hypothetical protein, similar to other hypothetical proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50411|Rv3384c|MTV004.42c (130 aa), FASTA scores: opt: 243, E(): 1.7e-09, (35.1% identity in 131 aa overlap); P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA scores: opt: 191, E(): 5e-06, (35.5% identity in 138 aa overlap), etc.; hypothetical protein	3826548..3826958	Mycobacterium tuberculosis H37Rv	887900
NP_217926.1	CDS	choD	NC_000962.2	3826991	3828727	R	Rv3409c, (MTCY78.19), len: 578 aa. Probable choD, cholesterol oxidase precursor (EC 1.1.3.6), equivalent to Q9CCV1|CHOD|ML0389 (alias Q59530|CHOD|B1620_C3_240) PUTATIVE CHOLESTEROL OXIDASE from Mycobacterium leprae (569 aa), FASTA scores: opt: 3510, E(): 3.8e-198, (88.6% identity in 569 aa overlap). Also highly similar to Q9L0H6|SCD63.13 PUTATIVE CHOLESTEROL OXIDASE from Streptomyces coelicolor (602 aa), FASTA scores: opt: 1101, E(): 5.2e-57, (60.05% identity in 586 aa overlap); and similar to other oxidoreductases e.g. Q9A7T6|CC1634 OXIDOREDUCTASE (GMC FAMILY) from Caulobacter crescentus (579 aa), FASTA scores: opt: 221, E(): 1.8e-05, (25.2% identity in 583 aa overlap). BELONGS TO THE GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD FLAVOPROTEIN. Contains PS00017 ATP/GTP-binding site motif A.; cholesterol oxidase precursor	complement(3826991..3828727)	Mycobacterium tuberculosis H37Rv	887502
NP_217927.1	CDS	guaB3	NC_000962.2	3828783	3829910	R	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase	complement(3828783..3829910)	Mycobacterium tuberculosis H37Rv	887510
NP_217928.1	CDS	guaB2	NC_000962.2	3829930	3831519	R	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase	complement(3829930..3831519)	Mycobacterium tuberculosis H37Rv	887498
NP_217929.1	CDS	Rv3412	NC_000962.2	3831726	3832136	D	Rv3412, (MTCY78.16c), len: 136 aa. Hypothetical protein, strongly similar to Q49742|YY12_MYCLE|ML0386|B1620_F3_131 HYPOTHETICAL 15.3 KDA PROTEIN from Mycobacterium leprae (137 aa), FASTA scores: opt: 933, E(): 6.3e-52, (93.4% identity in 136 aa overlap).; hypothetical protein	3831726..3832136	Mycobacterium tuberculosis H37Rv	887499
NP_217930.1	CDS	Rv3413c	NC_000962.2	3832146	3833045	R	Rv3413c, (MTCY78.16), len: 299 aa. Hypothetical unknown ala-, pro-rich protein.; hypothetical protein	complement(3832146..3833045)	Mycobacterium tuberculosis H37Rv	887925
NP_217931.1	CDS	sigD	NC_000962.2	3833038	3833676	R	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD	complement(3833038..3833676)	Mycobacterium tuberculosis H37Rv	887594
NP_217932.1	CDS	Rv3415c	NC_000962.2	3833694	3834521	R	Rv3415c, (MTCY78.14), len: 275 aa. Conserved hypothetical protein, equivalent to Q9CCV3|ML0383 HYPOTHETICAL PROTEIN from Mycobacterium leprae (281 aa), FASTA scores: opt: 1278, E(): 4.2e-71, (73.5% identity in 279 aa overlap). Also some similarity with P71677|RIBD_MYCTU|RIBG|Rv1409|MT1453|MTCY21B4.26 RIBOFLAVIN BIOSYNTHESIS PROTEIN R (339 aa), FASTA scores: opt: 143, E(): 0.13, (28.25% identity in 184 aa overlap).; hypothetical protein	complement(3833694..3834521)	Mycobacterium tuberculosis H37Rv	887599
NP_217933.1	CDS	whiB3	NC_000962.2	3834892	3835200	D	Rv3416, (MTCY78.13c), len: 102 aa. whiB3 (alternate gene name: whmB), WhiB-like regulatory protein (see citations below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q49871|WHIB3|WHIB|ML0382|B229_F1_2|B1620_F3_137 PROBABLE TRANSCRIPTION FACTOR WHIB3 from Mycobacterium leprae (102 aa), FASTA scores: opt: 657, E(): 7.9e-39, (86.25% identity in 102 aa overlap). Also highly similar to Q9Z6E9|WHIB3 from Mycobacterium smegmatis (96 aa), FASTA scores: opt: 604, E(): 3.5e-35, (80.4% identity in 102 aa overlap); and O88103|WHID|SC6G4.45c|WBLB from Streptomyces coelicolor (112 aa), FASTA scores: opt: 437, E(): 1.4e-23, (62.5% identity in 96 aa overlap). Also similar to O05847|WHIB1|Rv3219|MTCY07D11.07c from Mycobacterium tuberculosis (84 aa), FASTA scores: opt: 215, E(): 2.5e-08, (44.45% identity in 81 aa overlap). Note that primer extension analysis revealed three transcriptional start sites and that expression from the three potential promoters is growth phase-dependent (see Mulder et al., 1999). Moreover, the transcription of this CDS seems to be activated in macrophages (see Ramakrishnan et al., 2000).; whmB; transcriptional regulatory protein WHIB-like WHIB3	3834892..3835200	Mycobacterium tuberculosis H37Rv	887598
NP_217934.1	CDS	groEL	NC_000962.2	3835272	3836891	R	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; chaperonin GroEL	complement(3835272..3836891)	Mycobacterium tuberculosis H37Rv	887877
NP_217935.1	CDS	groES	NC_000962.2	3836986	3837288	R	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES	complement(3836986..3837288)	Mycobacterium tuberculosis H37Rv	887583
NP_217936.1	CDS	gcp	NC_000962.2	3837555	3838589	R	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease	complement(3837555..3838589)	Mycobacterium tuberculosis H37Rv	887595
NP_217937.1	CDS	rimI	NC_000962.2	3838586	3839062	R	Rv3420c, (MTCY78.09), len: 158 aa. Probable rimI, ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128), equivalent to C-terminal part of Q49857|YY21_MYCLE|ML0378|B229_C1_170 HYPOTHETICAL 38.0 KDA PROTEIN from Mycobacterium leprae (359 aa), FASTA scores: opt: 772, E(): 2.7e-44, (72.1% identity in 154 aa overlap). Similar notably to ribosomal-protein-alanine acetyltransferases e.g. Q9AC11|CC0058 from Caulobacter crescentus (150 aa), FASTA scores: opt: 223, E(): 4.9e-08, (37.5% identity in 136 aa overlap); Q9KFD4|BH0547 from Bacillus halodurans (151 aa), FASTA scores: opt: 222, E(): 5.8e-08, (35.2% identity in 142 aa overlap); Q9PG61|XF0441 from Xylella fastidiosa (156 aa), FASTA scores: opt: 207, E(): 5.9e-07, (32.2% identity in 149 aa overlap); Q9HVB7|RIMI|PA4678 from Pseudomonas aeruginosa (150 aa), FASTA scores: opt: 203, E(): 1.1e-06, (32.45% identity in 151 aa overlap); P09453|RIMI_ECOLI|B4373 from Escherichia coli strain K12 (148 aa), FASTA scores: opt: 196, E(): 3.1e-06, (33.55% identity in 149 aa overlap); etc. BELONGS TO THE ACETYLTRANSFERASE FAMILY, RIMI SUBFAMILY.; ribosomal-protein-alanine acetyltransferase	complement(3838586..3839062)	Mycobacterium tuberculosis H37Rv	887555
NP_217938.1	CDS	Rv3421c	NC_000962.2	3839059	3839694	R	Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 HYPOTHETICAL 38.0 KDA PROTEIN from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (GLYCOPROTEASE FAMILY PROTEIN) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa overlap); Q9KQK9|VC1989 from Vibrio cholerae (237 aa), FASTA scores: opt: 238, E(): 8.2e-07, (28.85% identity in 208 aa overlap); BAB51966|Mlr5530 from Rhizobium loti (Mesorhizobium loti) (225 aa), FASTA scores: opt: 237, E(): 9e-07, (35.0% identity in 220 aa overlap); etc. Some similarity to upstream Q50709|GCP_MYCTU|Rv3419c|MT3528|MTCY78.10 from Mycobacterium tuberculosis (344 aa), (33.9% identity in 127 aa overlap).; hypothetical protein	complement(3839059..3839694)	Mycobacterium tuberculosis H37Rv	887532
NP_217939.1	CDS	Rv3422c	NC_000962.2	3839691	3840197	R	Rv3422c, (MTCY78.07), len: 168 aa. Conserved hypothetical protein, equivalent to Q49864|YY22_MYCLE|ML0377|U229F|B229_C2_205 HYPOTHETICAL 17.6 KDA PROTEIN from Mycobacterium leprae (161 aa), FASTA scores: opt: 752, E(): 8.3e-38, (77.4% identity in 146 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86788|YJEE_STRCO|SC6G4.25 from Streptomyces coelicolor (148 aa), FASTA scores: opt: 377, E(): 1.2e-15, (50.85% identity in 120 aa overlap); Q9X1W7|TM1632 from Thermotoga maritima (161 aa), FASTA scores: opt: 247, E(): 6.2e-08, (39.4% identity in 137 aa overlap); Q9RRY1|DR2351 from Deinococcus radiodurans (148 aa), FASTA scores: opt: 236, E(): 2.6e-07, (38.6% identity in 127 aa overlap); etc. Contains PS00017 ATP /GTP-binding site motif A.; hypothetical protein	complement(3839691..3840197)	Mycobacterium tuberculosis H37Rv	887557
NP_217940.1	CDS	alr	NC_000962.2	3840194	3841420	R	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase	complement(3840194..3841420)	Mycobacterium tuberculosis H37Rv	887634
NP_217941.1	CDS	Rv3424c	NC_000962.2	3841714	3842076	R	Rv3424c, (MTCY78.05), len: 120 aa. Hypothetical unknown protein.; hypothetical protein	complement(3841714..3842076)	Mycobacterium tuberculosis H37Rv	887618
YP_177971.1	CDS	PPE57	NC_000962.2	3842239	3842769	D	Rv3425, (MTCY78.04c), len: 176 aa. Member of the M. tuberculosis PPE family, similar to many e.g. O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores: opt: 781, E(): 7e-44, (69.9% identity in 176 aa overlap); and downstream Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 517, E(): 1.2e-26, (68.0% identity in 125 aa overlap); MTV049_11, MTCY428_16, MTV049_22, MTV049_30, MTCY261_4; etc.; PPE family protein	3842239..3842769	Mycobacterium tuberculosis H37Rv	887635
YP_177972.1	CDS	PPE58	NC_000962.2	3843036	3843734	D	Rv3426, (MTCY78.03c), len: 232 aa. Member of the M. tuberculosis PPE family, similar to many e.g. the downstream O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores: opt: 555, E(): 6.5e-26, (72.0% identity in 125 aa overlap); and upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa), FASTA scores: opt: 517, E(): 1.1e-23, (68.0% identity in 125 aa overlap); MTV049_30, MTCY3C7_24, MTCY428_16, MTCY3A2_22; etc.; PPE family protein	3843036..3843734	Mycobacterium tuberculosis H37Rv	887622
NP_217944.1	CDS	Rv3427c	NC_000962.2	3843885	3844640	R	Rv3427c, (MTCY78.02), len: 251 aa. Possible transposase, similar to other e.g. Q9APG8|ORF2 PUTATIVE TRANSPOSASE SUBUNIT 2 from Pseudomonas putida (251 aa), FASTA scores: opt: 479, E(): 1.8e-21, (34.85% identity in 238 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.; transposase	complement(3843885..3844640)	Mycobacterium tuberculosis H37Rv	887631
NP_217945.1	CDS	Rv3428c	NC_000962.2	3844738	3845970	R	Rv3428c, (MTCY78.01, len: 410 aa. Possible transposase INSERTION SEQUENCE, similar to others e.g. Q9APG9|ORF1 from Pseudomonas putida (509 aa), FASTA scores: opt: 578, E(): 1.1e-29, (32.45% identity in 376 aa overlap); P55379|Y4BL_RHISN from Rhizobium sp. strain NGR234 (516 aa), FASTA scores: opt: 665, E(): 2.7e-35, (35.3% identity in 391 aa overlap); etc.; transposase	complement(3844738..3845970)	Mycobacterium tuberculosis H37Rv	887621
YP_177973.1	CDS	PPE59	NC_000962.2	3847165	3847701	D	Rv3429, (MTCY77.01), len: 178 aa. Member of the M. tuberculosis PPE family, similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa), FASTA scores: opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa overlap) (but diverges at 3' end)); etc.; PPE family protein	3847165..3847701	Mycobacterium tuberculosis H37Rv	887630
NP_217947.1	CDS	Rv3430c	NC_000962.2	3847642	3848805	R	Rv3430c, (MTCY77.02c), len: 387 aa. Possible IS1540 transposase, similar to several e.g. Q49592 transposase from Mycobacterium intracellulare (340 aa), FASTA scores: opt: 1377, E(): 1.6e-81, (64.2% identity in 338 aa overlap); similarity is lost at C-terminus due to possible frameshift after aa 297.; transposase	complement(3847642..3848805)	Mycobacterium tuberculosis H37Rv	887615
NP_217948.1	CDS	Rv3431c	NC_000962.2	3849294	3850139	R	Rv3431c, (MTCY77.03c), len: 281 aa. Possible truncated transposase for IS1552, similar to, but shorter than other transposases e.g. P72303 from Rhodococcus opacus (418 aa), FASTA scores: opt: 1509, E(): 1.2e-91, (80.95% identity in 278 aa overlap); Q9AKV5 from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 1115, E(): 7.8e-66, (63.45% identity in 268 aa overlap); etc.; hypothetical protein	complement(3849294..3850139)	Mycobacterium tuberculosis H37Rv	887608
NP_217949.1	CDS	gadB	NC_000962.2	3850372	3851754	R	Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB, glutamate decarboxylase (EC 4.1.1.15), similar to many e.g. P73043|GAD|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650, E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|GAD from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15% identity in 437 aa overlap); etc. BELONGS TO GROUP II DECARBOXYLASES (DDC, GAD, HDC AND TYRDC).; glutamate decarboxylase GadB	complement(3850372..3851754)	Mycobacterium tuberculosis H37Rv	887580
NP_217950.1	CDS	Rv3433c	NC_000962.2	3851792	3853213	R	Rv3433c, (MTCY77.05), len: 473 aa. Hypothetical protein, member of YKL151c/yjeF family, equivalent to P37391|YY33_MYCLE|ML0373|U229G|B229_C2_201 HYPOTHETICAL 47.2 KDA PROTEIN from Mycobacterium leprae (473 aa), FASTA scores: opt: 2650, E(): 5e-136, (84.55% identity in 473 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9X3W3 from Zymomonas mobilis (484 aa), FASTA scores: opt: 700, E(): 1.2e-30, (33.7% identity in 484 aa overlap); O86783|SC6G4.20c from Streptomyces coelicolor (485 aa), FASTA scores: opt: 563, E(): 3.2e-23, (48.45% identity in 489 aa overlap); Q9LC81 from Arthrobacter sp. Q36 (313 aa), FASTA scores: opt: 553, E(): 7.9e-23, (44.2% identity in 303 aa overlap); etc. Contains Pfam match to entry PF01256 hypothetical UPFOO31 family signature and PF03853 YjeF-related protein N-terminus. BELONGS TO THE UPF0031 FAMILY.; hypothetical protein	complement(3851792..3853213)	Mycobacterium tuberculosis H37Rv	887571
NP_217951.1	CDS	Rv3434c	NC_000962.2	3853215	3853928	R	Rv3434c, (MTCY77.06c), len: 237 aa. Possible conserved transmembrane protein, showing some similarity with Q9CGH7|YLDB HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (258 aa), FASTA scores: opt: 248, E(): 1.6e-09, (28.8% identity in 198 aa overlap); and P94983|Rv1648|MTCY06H11.13 from Mycobacterium tuberculosis (268 aa), FASTA scores: opt: 205, E(): 1.2e-06, (31.45% identity in 194 aa overlap).; transmembrane protein	complement(3853215..3853928)	Mycobacterium tuberculosis H37Rv	887573
NP_217952.1	CDS	Rv3435c	NC_000962.2	3853939	3854793	R	Rv3435c, (MTCY77.07c), len: 284 aa. Probable conserved transmembrane protein, showing some similarity with P95061|Rv0713|MTCY210.32 HYPOTHETICAL 33.9 KDA PROTEIN from Mycobacterium tuberculosis (313 aa), FASTA scores: opt: 557, E(): 1.3e-26, (35.8% identity in 282 aa overlap); and O32991|MLCB2492.12 from Mycobacterium leprae (95 aa), FASTA scores: opt: 150, E(): 0.022, (35.3% identity in 85 aa overlap). Equivalent to AAK47881 from Mycobacterium tuberculosis strain CDC1551 (312 aa) but shorter 28 aa.; transmembrane protein	complement(3853939..3854793)	Mycobacterium tuberculosis H37Rv	887564
NP_217953.1	CDS	glmS	NC_000962.2	3855015	3856889	R	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase	complement(3855015..3856889)	Mycobacterium tuberculosis H37Rv	887568
NP_217954.1	CDS	Rv3437	NC_000962.2	3856911	3857387	D	Rv3437, (MTCY77.09), len: 158 aa. Questionable ORF. Possible conserved transmenbrane protein, C-terminus similar to N-terminal part of O06345|Rv3482c|MTCY13E12.35c HYPOTHETICAL 28.5 KDA PROTEIN from Mycobacterium tuberculosis (260 aa), FASTA scores: opt: 140, E(): 0.1, (58.8% identity in 34 aa overlap); and Q9XAN5|SC4C6.05c PUTATIVE MEMBRANE PROTEIN from Streptomyces (347 aa), coelicolor FASTA scores: opt: 112, E(): 6.8, (50.0% identity in 32 aa overlap).; transmembrane protein	3856911..3857387	Mycobacterium tuberculosis H37Rv	887567
NP_217955.1	CDS	Rv3438	NC_000962.2	3857397	3858239	D	Rv3438, (MTCY77.10), len: 280 aa. Conserved hypothetical protein, equivalent to Q9CCV6|ML0370 HYPOTHETICAL PROTEIN from Mycobacterium leprae (289 aa), FASTA scores: opt: 1491, E(): 9.2e-81, (79.85% identity in 283 aa overlap); and highly similar (but shorter 41 aa) to Q49872|B229_F1_20 HYPOTHETICAL 34.0 KDA PROTEIN from Mycobacterium leprae (324 aa), FASTA scores: opt: 1491, E(): 1e-80, (79.85% identity in 283 aa overlap). Shows some similarity to Q9KIU3|LIPA LIPASE from plasmid pAH114 uncultured bacterium (281 aa), FASTA scores: opt: 168, E(): 0.0081, (29.3% identity in 140 aa overlap).; hypothetical protein	3857397..3858239	Mycobacterium tuberculosis H37Rv	887561
NP_217956.1	CDS	Rv3439c	NC_000962.2	3858259	3859662	R	Rv3439c, (MTCY77.11c), len: 467 aa. Conserved hypothetical ala-, pro-rich protein, similar in part to N-terminal part of Q49853|B229_C1_154 HYPOTHETICAL 11.2 KDA PROTEIN from Mycobacterium leprae (103 aa), FASTA scores: opt: 265, E(): 0.0013, (51.1% identity in 90 aa overlap).; hypothetical protein	complement(3858259..3859662)	Mycobacterium tuberculosis H37Rv	887565
NP_217957.1	CDS	Rv3440c	NC_000962.2	3859665	3859976	R	Rv3440c, (MTCY77.12c), len: 103 aa. Hypothetical unknown protein.; hypothetical protein	complement(3859665..3859976)	Mycobacterium tuberculosis H37Rv	887592
NP_217958.1	CDS	glmM	NC_000962.2	3860024	3861370	R	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase	complement(3860024..3861370)	Mycobacterium tuberculosis H37Rv	887589
NP_217959.1	CDS	rpsI	NC_000962.2	3861495	3861950	R	forms a direct contact with the tRNA during translation; 30S ribosomal protein S9	complement(3861495..3861950)	Mycobacterium tuberculosis H37Rv	887488
NP_217960.1	CDS	rplM	NC_000962.2	3861947	3862390	R	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13	complement(3861947..3862390)	Mycobacterium tuberculosis H37Rv	887584
NP_217961.1	CDS	esxT	NC_000962.2	3862624	3862926	R	Rv3444c, (MTCY77.16c), len: 100 aa. esxT, ESAT-6 like protein (see citation below), equivalent to Q9CCV7|ML0363 POSSIBLE SECRETED PROTEIN from Mycobacterium leprae (104 aa), FASTA scores: opt: 362, E(): 1.1e-18, (71.25% identity in 73 aa overlap). C-terminal part highly similar to Q49852|B229_C1_150 HYPOTHETICAL 5.3 KDA PROTEIN from Mycobacterium leprae (49 aa), FASTA scores: opt: 227, E(): 1.4e-09, (68.9% identity in 45 aa overlap). SEEMS TO BELONG TO THE ESAT6 FAMILY.; putative ESAT-6 like protein ESXT	complement(3862624..3862926)	Mycobacterium tuberculosis H37Rv	887587
NP_217962.1	CDS	esxU	NC_000962.2	3862947	3863324	R	Rv3445c, (MTCY77.17c), len: 125 aa. esxU, ESAT-6 like protein (see citations below), showing weak similarity to O30373|VCD|PA2257 PYOVERDINE BIOSYNTHESIS PROTEIN from Pseudomonas aeruginosa (215 aa), FASTA scores: opt: 103, E(): 5.6, (32.35% identity in 133 aa overlap). SEEMS TO BELONG TO THE ESAT6 FAMILY.; ESAT-6 like protein ESXU	complement(3862947..3863324)	Mycobacterium tuberculosis H37Rv	887585
NP_217963.1	CDS	Rv3446c	NC_000962.2	3863317	3864531	R	Rv3446c, (MTCY77.18c), len: 404 aa. Hypothetical unknown ala-, val-rich protein.; hypothetical protein	complement(3863317..3864531)	Mycobacterium tuberculosis H37Rv	887586
NP_217964.1	CDS	Rv3447c	NC_000962.2	3864528	3868238	R	Rv3447c, (MTCY77.19c), len: 1236 aa. Probable conserved membrane protein, similar to various bacterial proteins e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1186, E(): 1.9e-60, (42.9% identity in 1312 aa overlap); Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa), FASTA scores: opt: 932, E(): 9.2e-46, (27.2% identity in 1374 aa overlap); Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa), FASTA scores: opt: 910, E(): 1.5e-44, (34.4% identity in 1319 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa), FASTA scores: opt: 805, E(): 1.9e-38, (25.85% identity in 1292 aa overlap); etc. The C-terminal region is similar to Q9CDD7|ML0052 (alias O33086|MLCB628.15c) HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FASTA scores: opt: 850, E(): 2.3e-41, (35.2% identity in 588 aa overlap); and O6973|Rv3871|MTV027.06 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (591 aa), FASTA scores: opt: 845, E(): 4.3e-41, (35.3% identity in 586 aa overlap). N-terminal part shows similarity with HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis e.g. O69735|Rv3870|MTV027.05 (747 aa), FASTA scores: opt: 761, E(): 3.6e-36, (38.2% identity in 746 aa overlap). Equivalent to AAK47893 from Mycobacterium tuberculosis strain CDC1551 (1200 aa) but longer 36 aa. Contains three of PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	complement(3864528..3868238)	Mycobacterium tuberculosis H37Rv	887581
NP_217965.1	CDS	Rv3448	NC_000962.2	3868352	3869755	D	Rv3448, (MTCY77.20), len: 467 aa. Probable conserved integral membrane protein, showing some similarity with Q9CD35|ML2529 from Mycobacterium leprae (485 aa), FASTA scores: opt: 371, E(): 3.6e-14, (27.25% identity in 481 aa overlap); and two proteins from Mycobacterium tuberculosis O86362|Rv0290|MTV035.18 (472 aa), FASTA scores: opt: 429, E(): 1.6e-17, (28.6% identity in 479 aa overlap); and O05457|Rv3887c|MTCY15F10.25 (509 aa), FASTA scores: opt: 203, E(): 0.00019, (25.6% identity in 492 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.; integral membrane protein	3868352..3869755	Mycobacterium tuberculosis H37Rv	887624
NP_217966.1	CDS	mycP4	NC_000962.2	3869752	3871119	D	Rv3449, (MTCY13E12.02), len: 455 aa. Probable mycP4, membrane-anchored serine protease (mycosin) (EC 3.4.21.-) (see citation below), similar to hypothetical unknowns or proteases from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK48366|MT3998 SUBTILASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (411 aa), FASTA scores: opt: 747, E(): 3.5e-33, (45.65% identity in 416 aa overlap); O05461|Rv3883c|MTCY15F10.29 MEMBRANE-ANCHORED MYCOSIN MYCP1 (446 aa), FASTA scores: opt: 747, E(): 3.8e-33, (45.45% identity in 451 aa overlap); O53695|Rv0291|MTV035.19 PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP2 (461 aa), FASTA scores: opt: 660, E(): 1.9e-28, (44.0% identity in 457 aa overlap); etc. And similar to hypothetical proteases from Mycobacterium leprae e.g. O33076|MLCB628.04|ML0041 HYPOTHETICAL 45.7 KDA PROTEIN (PROBABLE SECRETED PROTEASE) (446 aa), FASTA scores: opt: 683, E(): 1.1e-29, (43.8% identity in 450 aa overlap); Q9CD36|ML2528 PUTATIVE PROTEASE (475 aa), FASTA scores: opt: 608, E(): 1.3e-25, (43.0% identity in 451 aa overlap); Q9CBV3|ML1538 POSSIBLE PROTEASE (567 aa), FASTA scores: opt: 389, E(): 9.7e-14, (33.8% identity in 562 aa overlap); etc. Also some similarity to other proteases from several organisms e.g. O31788|APRX ALKALINE SERINE PROTEASE from Bacillus subtilis (442 aa), FASTA scores: opt: 296, E(): 8.3e-09, (29.4% identity in 313 aa overlap); O86650|SC3C3.17c PUTATIVE SECRETED SERINE PROTEASE from Streptomyces coelicolor (450 aa), FASTA scores: opt: 279, E(): 7e-08, (33.55% identity in 343 aa overlap); Q9KBJ7|APRX|BH193 INTRACELLULAR ALKALINE SERINE PROTEASE from Bacillus halodurans (444 aa), FASTA scores: opt: 257, E(): 1.1e-06, (28.65% identity in 335 aa overlap); O86642|SC3C3.08 SERINE PROTEASE from Streptomyces coelicolor (413 aa), FASTA scores: opt: 243, E(): 5.7e-06, (38.25% identity in 387 aa overlap); etc. Has putative signal peptide at N-terminus and hydrophobic stretch at C-terminus. Contains three signatures typical of subtilase family: aspartic acid active site (PS00136), histidine active site (PS00137), and serine active site (PS00138). BELONGS TO PEPTIDASE FAMILY S8 (ALSO KNOWN AS THE SUBTILASE FAMILY), PYROLYSIN SUBFAMILY.; membrane-anchored mycosin	3869752..3871119	Mycobacterium tuberculosis H37Rv	887602
NP_217967.1	CDS	Rv3450c	NC_000962.2	3871084	3872496	R	Rv3450c, (MTCY13E12.03c), len: 470 aa. Probable conserved membrane protein (possible membrane spanning region near N-terminus). Similar to hypothetical unknowns proteins from Mycobacterium leprae e.g. O33088|MLCB628.17C|ML0054 HYPOTHETICAL 51.9 KDA PROTEIN (PUTATIVE MEMBRANE PROTEIN)(481 aa), FASTA scores: opt: 708, E(): 6.4e-32, (32.9% identity in 480 aa overlap); Q9CD29|ML2536 (552 aa), FASTA scores: opt: 394, E(): 1.7e-14, (33.6% identity in 503 aa overlap); etc. Also similar to other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O69734|Rv3869|MTV027.04 (480 aa), FASTA scores: opt: 717, E(): 2e-32, (32.55% identity in 479 aa overlap); O05449|Rv3895c|MTCY15F10.17 (495 aa), FASTA scores: opt: 670, E(): 8.3e-30, (36.4% identity in 475 aa overlap); O5368|Rv0283|MTV035.11 (538 aa), FASTA scores: opt: 467, E(): 1.5e-18, (36.3% identity in 493 aa overlap); etc.; hypothetical protein	complement(3871084..3872496)	Mycobacterium tuberculosis H37Rv	887619
NP_217968.2	CDS	cut3	NC_000962.2	3872617	3873405	D	Rv3451, (MTCY13E12.04), len: 262 aa. Probable cut3, cutinase precursor (EC 3.1.1.-), similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 214, E(): 2e-05, (31.45% identity in 210 aa overlap); Q9Y7G8 from Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203, E(): 8.5e-05, (31.05% identity in 190 aa overlap); P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA scores: opt: 155, E(): 0.054, (31.65% identity in 120 aa overlap). Similar to other proteins from Mycobacterium tuberculosis e.g. the downstream ORF O06319|Rv3452|MTCY13E12.05 HYPOTHETICAL 23.1 KDA PROTEIN (226 aa), FASTA scores: opt: 775, E(): 1e-37, (58.65% identity in 220 aa overlap); Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 565, E(): 1.3e-25, (44.85% identity in 223 aa overlap); Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 PROBABLE CUTINASE PRECURSOR (217 aa), FASTA scores: opt: 489, E(): 3e-21, (47.05% identity in 221 aa overlap); etc. Equivalent to AAK47897 from Mycobacterium tuberculosis strain CDC1551 (247 aa) but longer 15 aa. Contains cutinase, serine active site motif (PS00155). BELONGS TO THE CUTINASE FAMILY. Alternative start possible at 3733. Start changed since first submission (+15 aa).; cutinase precursor CUT3	3872617..3873405	Mycobacterium tuberculosis H37Rv	887611
NP_217969.1	CDS	cut4	NC_000962.2	3873452	3874132	D	Rv3452, (MTCY13E12.05), len: 226 aa. Probable cut4, cutinase precursor (EC 3.1.1.-), similar to other e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 522, E(): 7.3e-24, (46.6% identity in 221 aa overlap); P30272|CUTI_MAGGR|CUT1 from Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) (228 aa), FASTA scores: opt: 205, E(): 3.8e-05, (29.25% identity in 164 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 204, E(): 3.9e-05, (33.5% identity in 209 aa overlap); etc. Similar to other proteins from Mycobacterium tuberculosis e.g. upstream ORF O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 773, E(): 1.3e-38, (59.35% identity in 209 aa overlap); Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 704, E(): 1.3e-34, (53.4% identity in 219 aa overlap); etc. Contains PS00155 Cutinase, serine active site. BELONGS TO THE CUTINASE FAMILY. Alternative start possible at 4553 in cSCY13E12 but no RBS.; cutinase precursor CUT4	3873452..3874132	Mycobacterium tuberculosis H37Rv	887610
NP_217970.1	CDS	Rv3453	NC_000962.2	3874404	3874736	D	Rv3453, (MTCY13E12.06), len: 110 aa. Possible conserved transmembrane protein, showing weak similarity with other proteins e.g. Q9F6C3 PUTATIVE ABC TRANSPORTER from Propionibacterium thoenii (424 aa), FASTA scores: opt: 104, E(): 6.8, (40.6% identity in 69 aa overlap).; transmembrane protein	3874404..3874736	Mycobacterium tuberculosis H37Rv	887596
NP_217971.1	CDS	Rv3454	NC_000962.2	3874822	3876090	D	Rv3454, (MTCY13E12.07), len: 422 aa. Probable conserved integral membrane protein, showing some similarity to various proteins (generally transporters) e.g. Q9I5C8|PA0811 PROBABLE MFS TRANSPORTER from Pseudomonas aeruginosa (415 aa), FASTA scores: opt: 145, E(): 0.13, (28.2% identity in 188 aa overlap); Q01266|YHYC_PSESN HYPOTHETICAL PROTEIN IN HYUC 3'REGION (ORF 5) (FRAGMENT) from Pseudomonas sp. strain NS671 (245 aa), FASTA scores: opt: 130, E(): 0.75, (24.65% identity in 134 aa overlap); Q9I242|PA2073 PROBABLE TRANSPORTER (MEMBRANE SUBUNIT) from Pseudomonas aeruginosa (476 aa), FASTA scores: opt: 125, E(): 2.5, (24.6% identity in 252 aa overlap); etc. Equivalent to AAK47900 from Mycobacterium tuberculosis strain CDC1551 (562 aa) but shorter 140 aa. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; integral membrane protein	3874822..3876090	Mycobacterium tuberculosis H37Rv	887613
NP_217972.2	CDS	truA	NC_000962.2	3876052	3876945	R	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A	complement(3876052..3876945)	Mycobacterium tuberculosis H37Rv	887590
NP_217973.1	CDS	rplQ	NC_000962.2	3876890	3877432	R	is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17	complement(3876890..3877432)	Mycobacterium tuberculosis H37Rv	887523
NP_217974.1	CDS	rpoA	NC_000962.2	3877464	3878507	R	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha	complement(3877464..3878507)	Mycobacterium tuberculosis H37Rv	887629
NP_217975.1	CDS	rpsD	NC_000962.2	3878659	3879264	R	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4	complement(3878659..3879264)	Mycobacterium tuberculosis H37Rv	887620
NP_217976.1	CDS	rpsK	NC_000962.2	3879273	3879692	R	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11	complement(3879273..3879692)	Mycobacterium tuberculosis H37Rv	887524
NP_217977.1	CDS	rpsM	NC_000962.2	3879696	3880070	R	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13	complement(3879696..3880070)	Mycobacterium tuberculosis H37Rv	887514
NP_217978.1	CDS	rpmJ	NC_000962.2	3880286	3880399	R	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36	complement(3880286..3880399)	Mycobacterium tuberculosis H37Rv	887272
NP_217979.1	CDS	infA	NC_000962.2	3880432	3880653	R	stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1	complement(3880432..3880653)	Mycobacterium tuberculosis H37Rv	887325
NP_217980.1	CDS	Rv3463	NC_000962.2	3880907	3881764	D	Rv3463, (MTCY13E12.16), len: 285 aa. Conserved hypothetical protein, similar to Q9RDA2|SCE20.23 HYPOTHETICAL 31.4 KDA PROTEIN from Streptomyces coelicolor (290 aa), FASTA scores: opt: 770, E(): 2.2e-41, (48.6% identity in 247 aa overlap); and Q9X7Y1|SC6A5.35 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (341 aa), (see BLASTP results), FASTA scores: opt: 119, E(): 2.9, (24.1% identity in 274 aa overlap).; hypothetical protein	3880907..3881764	Mycobacterium tuberculosis H37Rv	888286
NP_217981.1	CDS	rmlB	NC_000962.2	3881837	3882832	D	Rv3464, (MTCY13E12.17), len: 331 aa. rmlB (alternate gene name: rfbB), dTDP-glucose-4,6-dehydratase (EC 4.2.1.46) (see citations below), nearly identical to Q50556|RMLB rhamnose biosynthesis protein (EC 4.2.1.46) from Mycobacterium tuberculosis (329 aa) (previously rfbB, now known as rmlB). Equivalent to Q9CBH7|RMLB|ML1964 DTDP-GLUCOSE 4,6-DEHYDRATASE (alias Q9X7A3|RMLB PUTATIVE DTDP-(GLUCOSE OR RHAMNOSE)-4,6-DEHYDRATASE (331 aa)) from Mycobacterium leprae (333 aa), FASTA scores: opt: 1925, E(): 1.9e-112, (84.0% identity in 331 aa overlap). Also highly similar to others e.g. Q9UZH2|RFBB|PAB0785 from Pyrococcus abyssi (333 aa), FASTA scores: opt: 1115, E(): 4.2e-62, (51.55% identity in 322 aa overlap); O27817|MTH1789 from Methanobacterium thermoautotrophicum (336 aa), FASTA scores: opt: 1104, E(): 2.1e-61, (51.65% identity in 331 aa overlap); BAB60064|TVG0950610 from Thermoplasma volcanium (318 aa), FASTA scores: opt: 1102, E(): 2.6e-61, (49.65% identity in 310 aa overlap); etc. Also related to P72050|MTCY13D12.18|RV3784 HYPOTHETICAL 36.3 KDA PROTEIN (SIMILAR TO GALACTOWALDENASES FROM EUKARYOTIC AND PROKARYOTIC ORIGIN) from Mycobacterium tuberculosis (326 aa), FASTA scores: E(): 1.4e-26, (33.8% identity in 320 aa overlap).; rfbB; dTDP-glucose 4,6-dehydratase RMLB	3881837..3882832	Mycobacterium tuberculosis H37Rv	887332
NP_217982.1	CDS	rmlC	NC_000962.2	3882834	3883442	D	Rv3465, (MTCY13E12.18), len: 202 aa. rmlC (alternate gene name: rfbC), dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (see citations below), nearly identical to O33170|RMLC RMLC PROTEIN from Mycobacterium tuberculosis (203 aa), FASTA scores: opt: 1171, E(): 2.6e-71, (89.5% identity in 200 aa overlap) (previously known as rfbC). Equivalent to Q9X7A4|RMLC|ML1965 PUTATIVE DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE from Mycobacterium leprae (202 aa), FASTA scores: opt: 1072, E(): 1.1e-64, (75.4% identity in 199 aa overlap). Also highly similar to others e.g. Q9F8S7|CUMY from Streptomyces rishiriensis (198 aa), FASTA scores: opt: 671, E(): 7e-38, (51.3% identity in 193 aa overlap); Q9L6C5 from Streptomyces antibioticus (202 aa), FASTA scores: opt: 665, E(): 1.8e-37, (49.25% identity in 197 aa overlap); P29783|STRM_STRGR from Streptomyces griseus (200 aa), FASTA scores: opt: 608, E(): 1.2e-33, (49.25% identity in 201 aa overlap); Q54265|STRM from Streptomyces glaucescens (200 aa), FASTA scores: opt: 603, E(): 2.5e-33, (46.7% identity in 197 aa overlap); etc. Also highly similar to Q9S4D4|TYLJ PUTATIVE NDP-HEXOSE 3-EPIMERASE from Streptomyces fradiae (205 aa), FASTA scores: opt: 625, E(): 8.6e-35, (45.9% identity in 194 aa overlap).; rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase RmlC	3882834..3883442	Mycobacterium tuberculosis H37Rv	887352
NP_217983.1	CDS	Rv3466	NC_000962.2	3883525	3884193	D	Rv3466, (MTCY13E12.19), len: 222 aa. Conserved hypothetical ORF in REP13E12 repeat, but extending 5' of repeat. Has segment of identity to other REP13E12 ORF's e.g. MTCY336.16, MTCI65.15c, MTCY09F9.19, cMTCY251.14c.; hypothetical protein	3883525..3884193	Mycobacterium tuberculosis H37Rv	887830
NP_217984.1	CDS	Rv3467	NC_000962.2	3883964	3884917	D	Rv3467, (MTCY13E12.20), len: 317 aa. Conserved hypothetical ORF in REP13E12 repeat, identical to ORF's from other REP13E12 copies e.g. MTCY251.13c, MTCI65.15c, MTCY09F9.19, cMTCY336.17. Also identical to Mycobacterium bovis Q50655 HYPOTHETICAL 34.6 kDa PROTEIN (317 aa) in identical repeat.; hypothetical protein	3883964..3884917	Mycobacterium tuberculosis H37Rv	888022
YP_177974.1	CDS	Rv3468c	NC_000962.2	3884975	3886069	R	Rv3468c, (MTCY13E12.21c), len: 364 aa. Possible dTDP-glucose-4,6-dehydratase (EC 4.2.1.46), but experimental study shown that the purified protein didn't have dTDP-glucose dehydratase (rmlB) activity (see citation below). Similar to others e.g. O08246|MTME from Streptomyces argillaceus (331 aa), FASTA scores: opt: 238, E(): 1.2e-07, (29.65% identity in 344 aa overlap); Q9LFG7|F4P12_220 from Arabidopsis thaliana (Mouse-ear cress) (433 aa), FASTA scores: opt: 237, E(): 1.8e-07, (27.25% identity in 308 aa overlap); Q9LZI2|F26K9_260 from Arabidopsis thaliana (Mouse-ear cress) (445 aa), FASTA scores: opt: 225, E(): 1e-06, (25.95% identity in 335 aa overlap); etc. Also similar to various enzymes and hypothetical unknowns proteins e.g. BAB48655|MLL1234 UDP-GLUCOSE 4-EPIMERASE from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 757, E(): 4.6e-40, (43.4% identity in 302 aa overlap). First start taken, alternative at 17080 in cSCYY13E12 suggested by similarity. Note that previously known as rmlB3 (see citation below).; rmlB3; dTDP-glucose 4,6-dehydratase	complement(3884975..3886069)	Mycobacterium tuberculosis H37Rv	888007
NP_217986.1	CDS	mhpE	NC_000962.2	3886073	3887083	R	catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase	complement(3886073..3887083)	Mycobacterium tuberculosis H37Rv	888074
NP_217987.1	CDS	ilvB2	NC_000962.2	3887144	3888802	R	Rv3470c, (MTCY13E12.23c), len: 552 aa. Probable ilvB2, acetolactate synthase large subunit (EC 4.1.3.18), similar to others e.g. P73913|ILVG|SLR2088 from Synechocystis sp. strain PCC 6803 (621 aa), FASTA scores: opt: 779, E(): 4.5e-39, (30.7% identity in 567 aa overlap); O78518|ILVB_GUITH from Guillardia theta (Cryptomonas phi) (575 aa), FASTA scores: opt: 742, E(): 6.9e-37, (28.8% identity in 566 aa overlap); Q59950|ILVX from Spirulina platensis (612 aa), FASTA scores: opt: 715, E(): 3e-35, (28.45% identity in 569 aa overlap); etc. Contains thiamine pyrophosphate enzymes signature (PS00187).; acetolactate synthase large subunit	complement(3887144..3888802)	Mycobacterium tuberculosis H37Rv	888041
NP_217988.1	CDS	Rv3471c	NC_000962.2	3888808	3889341	R	Rv3471c, (MTCY13E12.24c), len: 177 aa. Conserved hypothetical protein, similar to Q59013|MJ1618 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (125 aa), FASTA scores: opt: 262, E(): 1.2e-09, (39.05% identity in 105 aa overlap); and O26452|MTH352 CONSERVED PROTEIN from Methanobacterium thermoautotrophicum (131 aa), FASTA scores: opt: 222, E(): 3.8e-07, (35.05% identity in 117 aa overlap). Equivalent to AAK47934 from Mycobacterium tuberculosis strain CDC1551 (184 aa) but shorter 7 aa.; hypothetical protein	complement(3888808..3889341)	Mycobacterium tuberculosis H37Rv	888050
NP_217989.1	CDS	Rv3472	NC_000962.2	3889362	3889868	D	Rv3472, (MTCY13E12.25), len: 168 aa. Conserved hypothetical protein, showing some similarity to other proteins e.g. Q9ZAT9|DPSH DAUNORUBICIN BIOSYNTHESIS ENZYME from Streptomyces peucetius (194 aa), FASTA scores: opt: 181, E(): 6.8e-05, (30.7% identity in 127 aa overlap); Q53879 DAUH/E from Streptomyces sp. C5 (151 aa), FASTA scores: opt: 168, E(): 0.00038, (29.25% identity in 127 aa overlap); and Q9L4U3|AKNV from Streptomyces galilaeus (144 aa), FASTA scores: opt: 122, E(): 0.36, (31.25% identity in 129 aa overlap).; hypothetical protein	3889362..3889868	Mycobacterium tuberculosis H37Rv	888006
NP_217990.1	CDS	bpoA	NC_000962.2	3889948	3890733	R	Rv3473c, (MTCY13E12.26c), len: 261 aa. Possible bpoA, peroxidase (non-haem peroxidase) (EC 1.11.1.-), similar to various enzymes or hypothetical unknown proteins e.g. O85849 HYPOTHETICAL 26.2 KDA PROTEIN from Sphingomonas aromaticivorans (247 aa), FASTA scores: opt: 684, E(): 4.9e-34, (43.8% identity in 242 aa overlap); AAK45412|MT1155 HYDROLASE, ALPHA/BETA HYDROLASE FOLD FAMILY from Mycobacterium tuberculosis strain CDC1551 (311 aa), FASTA scores: opt: 675, E(): 2e-33, (39.45% identity in 256 aa overlap); Q9K3V0|SCD10.27 PUTATIVE HYDROLASE from Streptomyces coelicolor (352 aa), FASTA scores: opt: 248, E(): 9.7e-08, (26.05% identity in 261 aa overlap); P29715|BPA2_STRAU|BPOA2 NON-HAEM BROMOPEROXIDASE (EC 1.11.1.-) (BROMIDE PEROXIDASE) (277 aa), FASTA scores: opt: 237, E(): 3.6e-07, (29.45% identity in 265 aa overlap); O31168|PRXC_STRAU|CPO|CPOT NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (278 aa), FASTA scores: opt: 236, E(): 4.2e-07, (29.45% identity in 265 aa overlap); AAK62388|T5L19.180 LIPASE-LIKE PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (350 aa), FASTA scores: opt: 236, E(): 5.1e-07, (26.65% identity in 274 aa overlap); etc. Also similar to O06575|BPOB|Rv1123c|MTCY22G8.12c HYPOTHETICAL 32.5 KDA PROTEIN from Mycobacterium tuberculosis (302 aa), FASTA scores: opt: 675, E(): 2e-33, (39.45% identity in 256 aa overlap). Equivalent to AAK47936 from Mycobacterium tuberculosis strain CDC1551 (294 aa) but shorter 33 aa. May have been inactivated or truncated by neighbouring IS6110.; peroxidase BpoA	complement(3889948..3890733)	Mycobacterium tuberculosis H37Rv	888101
NP_217991.1	CDS	Rv3474	NC_000962.2	3890830	3891156	D	first part; Rv3474, (MTCY13E12.27), len: 108 aa. Possible transposase (first part), probably frameshifts (-1) with MTCY13E12.28|Rv3475 to make full length product. Identical to Q50686|YIA4_MYCTU INSERTION ELEMENT IS6110 HYPOTHETICAL 12.0 kDa PROTEIN (108 aa). BELONGS TO THE TRANSPOSASE FAMILY 8; transposase IS6110	3890830..3891156	Mycobacterium tuberculosis H37Rv	888097
NP_217992.1	CDS	Rv3475	NC_000962.2	<3891051	3892091	D	[SECOND PART]; Rv3475, (MTCY13E12.28), len: 346 aa. Possible IS6110 transposase (second part), probably made by a frameshift (-1) with MTCY13E12.27|Rv3474. Identical to P19774|TRA9_MYCTU PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS986/IS6110 (278 aa); transposase IS6110	<3891051..3892091	Mycobacterium tuberculosis H37Rv	888055
NP_217993.1	CDS	kgtP	NC_000962.2	3892371	3893720	R	Rv3476c, (MTCY13E12.29c), len: 449 aa. Probable kgtP, dicarboxylate-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), highly similar to others e.g. Q9HT43|PA5530 from Pseudomonas aeruginosa (435 aa), FASTA scores: opt: 1209, E(): 2.3e-68, (47.05% identity in 425 aa overlap); Q9I6Q9|PCAT|PA0229 from Pseudomonas aeruginosa (432 aa), FASTA scores: opt: 1131, E(): 1.8e-63, (40.4% identity in 438 aa overlap); Q9WWZ2 from Pseudomonas putida (429 aa), FASTA scores: opt: 1090, E(): 6.5e-61, (41.2% identity in 425 aa overlap); P17448|KGTP_ECOLI|WITA|B2587 from Escherichia coli strain K12 (432 aa), FASTA scores: opt: 1083, E(): 1.8e-60, (40.05% identity in 422 aa overlap); etc. Also similar to O05301|MTCI364.12|Rv1200 HYPOTHETICAL 44.6 KDA PROTEIN from Mycobacterium tuberculosis (425 aa), FASTA scores: E(): 5.2e-25, (28.5% identity in 382 aa overlap). Contains sugar transport protein signatures 1 and 2 (PS00216, PS00217). BELONG TO THE SUGAR TRANSPORTER FAMILY.; dicarboxylic acid transport integral membrane protein KgtP	complement(3892371..3893720)	Mycobacterium tuberculosis H37Rv	888002
YP_177975.1	CDS	PE31	NC_000962.2	3894093	3894389	D	Rv3477, (MTCY13E12.30), len: 98 aa. Member of the Mycobacterium tuberculosis PE family (see Brennan & Delogu 2002), similar to O53941|Rv1791|MTV049.13 (99 aa), FASTA scores: opt: 373, E(): 4.3e-18, (64.65% identity in 99 aa overlap); MTCI364.07; MTCY21C12.10c; MTCY1A11.25c; MTC1A11.04; MTCY359.33; etc.; PE family protein	3894093..3894389	Mycobacterium tuberculosis H37Rv	888474
YP_177976.1	CDS	PPE60	NC_000962.2	3894426	3895607	D	Rv3478, (MTCY13E12.31), len: 393 aa. PPE60 (alternate gene name: mtb39c). Member of the M. tuberculosis PPE family, highly similar to others e.g. Q11031|YD61_MYCTU|Rv1361c|MT1406|MTCY02B10.25c (396 aa), FASTA scores: opt: 2165, E(): 1.1e-109, (85.35% identity in 396 aa overlap); MTCI364.08; MTCY10G2.10; MTCY03A2.22c; MTCY274.23c; MTCY164.34c; MTCY98.0029c; etc. Note that expression of Rv3478 was demonstrated in lysates by immunodetection (see Dillon et al., 1999).; mtb39c; PE family protein	3894426..3895607	Mycobacterium tuberculosis H37Rv	888047
NP_217996.2	CDS	Rv3479	NC_000962.2	3895820	3898885	D	Rv3479, (MTCY13E12.32), len: 1021 aa. Possible transmembrane protein, with hydrophobic stretches at C-terminus. Start changed since first submission (-54 aa).; hypothetical protein	3895820..3898885	Mycobacterium tuberculosis H37Rv	888478
NP_217997.1	CDS	Rv3480c	NC_000962.2	3898909	3900402	R	Rv3480c, (MTCY13E12.33c), len: 497 aa. Conserved hypothetical protein, similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa), FASTA scores: opt: 520, E(): 2e-23, (39.95% identity in 488 aa overlap); Q10554|Y895_MYCTU|Rv0895|MTCY31.23 (505 aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); AAK45165|MT0919 (520 aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa overlap); etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 272, E(): 1e-08, (28.85% identity in 485 aa overlap); and Q9RIU8|CM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 254, E(): 1.1e-07, (30.4% identity in 497 aa overlap). SEEMS TO BELONG TO THE UPF0089 FAMILY. TBparse score is 0.917.; hypothetical protein	complement(3898909..3900402)	Mycobacterium tuberculosis H37Rv	888473
NP_217998.1	CDS	Rv3481c	NC_000962.2	3900493	3901182	R	Rv3481c, (MTCY13E12.34c), len: 229 aa. Probable integral membrane protein. No real similarity with others.; integral membrane protein	complement(3900493..3901182)	Mycobacterium tuberculosis H37Rv	888466
NP_217999.1	CDS	Rv3482c	NC_000962.2	3901324	3902106	R	Rv3482c, (MTCY13E12.35c), len: 260 aa. Probable conserved membrane protein. N-terminal region shares some similarity with N-terminus of O88067|SCI35.32c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (319 aa), FASTA scores: opt: 155, E(): 0.023, (54.55% identity in 33 aa overlap); and with C-terminus of O06254|Rv3437|MTCY77.09 HYPOTHETICAL 17.9 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (alias AAK47883|MT3542.1 from strain CDC1551) (158 aa), FASTA scores: opt: 140, E(): 0.11, (58.8% identity in 34 aa overlap). Some similarity to others e.g. Q9XAN5|SC4C6.05c PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (347 aa), FASTA scores: opt: 131, E(): 0.75, (29.4% identity in 221 aa overlap). First start taken.; hypothetical protein	complement(3901324..3902106)	Mycobacterium tuberculosis H37Rv	888480
NP_218000.1	CDS	Rv3483c	NC_000962.2	3902150	3902812	R	Rv3483c, (MTCY13E12.36c), len: 220 aa. Conserved hypothetical protein (see citation below), similar to Q9CC94|ML1099 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (202 aa), FASTA scores: opt: 276, E(): 1.4e-08, (33.1% identity in 148 aa overlap). Also showing similarity with Mycobacterium tuberculosis proteins Q11065|LPRE_MYCTU|LPRE|Rv1252c|MT1291|MTCY50.30. PUTATIVE LIPOPROTEIN PRECURSOR (202 aa), FASTA scores: opt: 276, E(): 1.4e-08, (29.5% identity in 200 aa overlap); O53445|Rv1097c|MTV017.50c HYPOTHETICAL 29.9 KDA PROTEIN (293 aa), FASTA scores: opt: 161, E(): 0.047, (25.4% identity in 118 aa overlap); P71882|LPPP_MYCTU|Rv2330c|MT2392|MTCY3G12.04 PUTATIVE LIPOPROTEIN PRECURSOR (175 aa), FASTA scores: opt: 146, E(): 0.21, (28.25% identity in 184 aa overlap); and O06170|Rv2507|MTCY07A7.13 HYPOTHETICAL 28.5 KDA PROTEIN (273 aa), FASTA scores: opt: 148, E(): 0.23, (25.15% identity in 191 aa overlap).; hypothetical protein	complement(3902150..3902812)	Mycobacterium tuberculosis H37Rv	888448
NP_218001.1	CDS	cpsA	NC_000962.2	3903078	3904616	D	Rv3484, (MTCY13E12.37), len: 512 aa. Possible cpsA, hypothetical protein, equivalent to Q50160|CPSA|ML2247 HYPOTHETICAL PROTEIN CPSA from Mycobacterium leprae (516 aa), FASTA scores: opt: 2557, E(): 1.6e-143, (74.9% identity in 518 aa overlap); and with good similarity to Q9CCK9|ML0750 HYPOTHETICAL PROTEIN from Mycobacterium leprae (489 aa), FASTA scores: opt: 855, E(): 4.6e-43, (34.45% identity in 502 aa overlap). Also similar (or with similarity) to hypothetical proteins from Mycobacterium tuberculosis: P96872|Rv3267|MTCY71.07 (498 aa), FASTA scores: opt: 928, E(): 2.3e-47, (37.35% identity in 498 aa overlap); and O53834|Rv0822c|MTV043.14c (684 aa), FASTA scores: opt: 425, E(): 1.5e-17, (26.15% identity in 524 aa overlap). Shows also similarity with various bacterial proteins e.g. Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (507 aa), FASTA scores: opt: 329, E(): 5.3e-12, (28.85% identity in 478 aa overlap); Q9K4E6|2SC6G5.02 CONSERVED HYPOTHETICAL PROTEIN, POSSIBLE MEMBRANE PROTEIN, from Streptomyces coelicolor (382 aa), FASTA scores: opt: 305, E(): 1.1e-10, (29.8% identity in 386 aa overlap); O69850|SC1C3.08c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (366 aa), FASTA scores: opt: 304, E(): 1.2e-10, (29.6% identity in 395 aa overlap); Q9KZK3|SCE34.23 PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (396 aa), FASTA scores: opt: 296, E(): 3.8e-10, (31.25% identity in 349 aa overlap); AAK43602|CPSA CPSA PROTEIN from Streptococcus agalactiae (485 aa), FASTA scores: opt: 250, E(): 2.4e-07, (30.25% identity in 162 aa overlap); etc.; hypothetical protein	3903078..3904616	Mycobacterium tuberculosis H37Rv	888445
NP_218002.1	CDS	Rv3485c	NC_000962.2	3904622	3905566	R	Rv3485c, (MTCY13E12.38c), len: 314 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar, but longer 41 aa, to P71824|Rv0769|MTCY369.14 PUTATIVE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE CY369.14 from Mycobacterium tuberculosis (248 aa), FASTA scores: opt: 462, E(): 1.8e-19, (34.0% identity in 253 aa overlap). Also similar to various dehydrogenases e.g. P25529|HDHA_ECOLI|HSDH|B1619 NAD-DEPENDENT 7 ALPHA-HYDROXYSTEROID DEHYDROGENASE (SDR FAMILY) (EC 1.1.1.159) from Escherichia coli strain K12 (alias BAB35750|ECS2327 or AAG56608|HDHA for strain O157:H7) (255 aa), FASTA scores: opt: 462, E(): 1.8e-19, (34.7% identity in 248 aa overlap); Q9FD15|RUBG PUTATIVE REDUCTASE (SDR FAMILY) from Streptomyces collinus (249 aa), FASTA scores: opt: 446, E(): 1.5e-18, (36.1% identity in 255 aa overlap); BAB51974|MLL5540 PUTATIVE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (253 aa), FASTA scores: opt: 442, E(): 2.5e-18, (36.25% identity in 251 aa overlap); Q08632|SDR1_PICAB SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE (SDR FAMILY) from Picea abies (Norway spruce) (Picea excelsa) (271 aa), FASTA scores: opt: 441, E(): 3.1e-18, (32.3% identity in 260 aa overlap); Q9A326|CC3380 2-DEOXY-D-GLUCONATE 3-DEHYDROGENASE from Caulobacter crescentus (260 aa), FASTA scores: opt: 436, E(): 5.7e-18, (32.8% identity in 253 aa overlap); Q16698|DECR_HUMAN 2,4-DIENOYL-COA REDUCTASE, MITOCHONDRIAL PRECURSOR (EC 1.3.1.34) from Homo sapiens (Human) (335 aa), FASTA scores: opt: 430, E(): 1.5e-17, (30.4% identity in 306 aa overlap); etc. Contains short-chain alcohol dehydrogenase family signature (PS00061). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY (SDR).; short chain dehydrogenase	complement(3904622..3905566)	Mycobacterium tuberculosis H37Rv	888427
NP_218003.1	CDS	Rv3486	NC_000962.2	3905772	3906221	D	Rv3486, (MTCY13E12.39), len: 149 aa. Conserved hypothetical protein, similar to Q9RC47|YFID|BH3304 HYPOTHETICAL PROTEIN from Bacillus halodurans (129 aa), FASTA scores: opt: 186, E(): 2.1e-05, (40.0% identity in 95 aa overlap); and Q9KKT1|VCA1019 HYPOTHETICAL PROTEIN from Vibrio cholerae (148 aa), FASTA scores: opt: 128, E(): 0.15, (35.25% identity in 139 aa overlap). Some similarity to other proteins e.g. P54720|YFID_BACSU HYPOTHETICAL PROTEIN from Bacillus subtilis (134 aa), FASTA scores: opt: 165, E(): 0.00052, (31.75% identity in 126 aa overlap). Equivalent to AAK47949 from Mycobacterium tuberculosis strain CDC1551 (163 aa) but shorter 14 aa.; hypothetical protein	3905772..3906221	Mycobacterium tuberculosis H37Rv	888276
NP_218004.1	CDS	lipF	NC_000962.2	3906174	3907007	R	Rv3487c, (MTCY13E12.41c), len: 277 aa. Probable lipF, esterase/lipase (EC 3.-.-.-) (see citation below), highly similar, but shorter 50 aa, to O53424|LIPU|Rv1076|MTV017.29 PUTATIVE ESTERASE/LIPASE from Mycobacterium tuberculosis (297 aa), FASTA scores: opt: 1229, E(): 3.3e-71, (76.4% identity in 246 aa overlap); and similar to other putative lipases from Mycobacterium tuberculosis e.g. P71759|LIPK|RV2385|MTCY253.36c (306 aa), FASTA scores: opt: 468, E(): 1.2e-22, (36.2% identity in 254 aa overlap). Equivalent, but shorter 79 aa, to Q9ZBM4|MLCB1450.08|ML0314 PUTATIVE HYDROLASE (PUTATIVE ESTERASE) from Mycobacterium leprae (335 aa), FASTA scores: opt: 1225, E(): 6.6e-71, (73.6% identity in 250 aa overlap). Also similar to esterases and lipases of around 300 aa e.g. Q44087|EST ESTERASE PRECURSOR from Acinetobacter lwoffii (303 aa), FASTA scores: opt: 428, E(): 4.3e-20, (31.85% identity in 251 aa overlap); P18773|EST_ACICA ESTERASE (EC 3.1.1.-) from Acinetobacter calcoaceticus (303 aa), FASTA scores: opt: 420, E(): 1.4e-19, (31.5% identity in 251 aa overlap); Q9KIU1 ESTERASE from uncultured bacterium Plasmid pAH116 (308 aa), FASTA scores: opt: 405, E(): 1.3e-18, (35.1% identity in 242 aa overlap); Q9X8J4|SCE9.22 PUTATIVE ESTERASE from Streptomyces coelicolor (266 aa), FASTA scores: opt: 390, E(): 1e-17, (35.85% identity in 237 aa overlap); etc. Equivalent to AAK47950 from Mycobacterium tuberculosis strain CDC1551 (327 aa) but shorter 50 aa. TBparse score is 0.940.; esterase/lipase LipF	complement(3906174..3907007)	Mycobacterium tuberculosis H37Rv	888430
NP_218005.1	CDS	Rv3488	NC_000962.2	3907667	3907990	D	Rv3488, (MTCY13E12.41), len: 107 aa. Hypothetical protein, similar to various bacterial proteins e.g. O28730|AF1542 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (101 aa), FASTA scores: opt: 321, E(): 6.4e-15, (50.55% identity in 87 aa overlap); O50207 SQ1_IV (FRAGMENT) from Rhodococcus erythropolis (59 aa), FASTA scores: opt: 298, E(): 1.4e-13, (71.2% identity in 59 aa overlap); Q9KFB0|BH0575 BH0575 PROTEIN from Bacillus halodurans (102 aa), FASTA scores: opt: 294, E(): 4.1e-13, (43.15% identity in 95 aa overlap); etc. Also similar to Mycobacterium tuberculosis P71704|Rv0047c|MTCY21D4.10c (180 aa) (37.8% identity in 82 aa overlap).; hypothetical protein	3907667..3907990	Mycobacterium tuberculosis H37Rv	888417
NP_218006.1	CDS	Rv3489	NC_000962.2	3908072	3908236	D	Rv3489, (MTCY13E12.42), len: 54 aa. Hypothetical unknown protein. No similarity with other proteins.; hypothetical protein	3908072..3908236	Mycobacterium tuberculosis H37Rv	888410
NP_218007.1	CDS	otsA	NC_000962.2	3908236	3909738	D	Rv3490, (MTCY13E12.43), len: 500 aa. Probable otsA, alpha, alpha-trehalose-phosphate synthase (EC 2.4.1.15) (see citations below), equivalent to Q50167|OTSA|ML2254 PROBABLE TREHALOSE-PHOSPHATE SYNTHASE from Mycobacterium leprae (498 aa), FASTA scores: opt: 2706, E(): 1.6e-166, (80.3% identity in 497 aa overlap). Also similar to others e.g. Q92410|TPS1_CANAL from Candida albicans (Yeast) (478 aa), FASTA scores: opt: 895, E(): 4.9e-50, (37.15% identity in 479 aa overlap); Q00764|TPS1_YEASTTPS1|CIF1|BYP1|FDP1|GGS1|GLC6|YBR126c|YB R0 922 from Saccharomyces cerevisiae (Baker's yeast) (495 aa), FASTA scores: opt: 847, E(): 6.2e-47, (36.1% identity in 490 aa overlap); BAB48232|MLL0691 from Rhizobium loti (Mesorhizobium loti) (520 aa), FASTA scores: opt: 884, E(): 2.7e-49, (36.2% identity in 478 aa overlap); etc. Equivalent to AAK47953 from Mycobacterium tuberculosis strain CDC1551 (478 aa) but longer 22 aa.; alpha,alpha-trehalose-phosphate synthase	3908236..3909738	Mycobacterium tuberculosis H37Rv	888404
NP_218008.1	CDS	Rv3491	NC_000962.2	3909890	3910468	D	Rv3491, (MTCY13E12.44), len: 192 aa. Hypothetical unknown protein. No significant homology with other proteins.; hypothetical protein	3909890..3910468	Mycobacterium tuberculosis H37Rv	888382
NP_218009.1	CDS	Rv3492c	NC_000962.2	3910465	3910947	R	Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa), FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213).; Mce associated protein	complement(3910465..3910947)	Mycobacterium tuberculosis H37Rv	888381
NP_218010.1	CDS	Rv3493c	NC_000962.2	3910947	3911675	R	Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 HYPOTHETICAL 25.9 KDA PROTEIN (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap).; Mce associated alanine and valine rich protein	complement(3910947..3911675)	Mycobacterium tuberculosis H37Rv	888379
NP_218011.1	CDS	mce4F	NC_000962.2	3911675	3913369	R	Rv3494c, (MTV023.01c), len: 564 aa. mce4F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa); O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); and O53972|Rv1971|MTV051.09|mce3F (437 aa). Also similar to others e.g. Q9CD09|MCE1F|ML2594 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (516 aa), FASTA scores: opt: 1040, E(): 3.6e-31, (35.9% identity in 529 aa overlap); Q9F361|SC8A2.02c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (433 aa), FASTA scores: opt: 570, E(): 3.7e-14, (30.8% identity in 458 aa overlap); etc. Has hydrophobic stretch, possibly a signal peptide at the N-terminus. TBparse score is 0.897.; MCE-family protein MCE4F	complement(3911675..3913369)	Mycobacterium tuberculosis H37Rv	888376
NP_218012.1	CDS	lprN	NC_000962.2	3913380	3914534	R	Rv3495c, (MTV023.02c), len: 384 aa. Possible lprN (alternate gene name: mce4E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa); O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa); and O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa). Also similar to others e.g. Q9F360|SC8A2.03c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (413 aa), FASTA scores: opt: 656, E(): 2.2e-32, (37.55% identity in 317 aa overlap); Q9CD10|LPRK|ML2593 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (392 aa), FASTA scores: opt: 616, E(): 5.5e-30, (28.95% identity in 373 aa overlap); etc. Contains possible signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.897.; mce4E; MCE-family lipoprotein LprN	complement(3913380..3914534)	Mycobacterium tuberculosis H37Rv	888364
NP_218013.1	CDS	mce4D	NC_000962.2	3914531	3915886	R	Rv3496c, (MTV023.03c), len: 451 aa. mce4D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); and O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to others e.g. Q9CD11|MCE1D|ML2592 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (531 aa), FASTA scores: opt: 837, E(): 2.6e-34, (34.55% identity in 446 aa overlap); Q9F359|SC8A2.04c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (337 aa), FASTA scores: opt: 606, E(): 4.9e-23, (32.35% identity in 300 aa overlap); etc. Hydrophobic region at N-terminus. TBparse score is 0.891.; MCE-family protein MCE4D	complement(3914531..3915886)	Mycobacterium tuberculosis H37Rv	888361
NP_218014.1	CDS	mce4C	NC_000962.2	3915883	3916956	R	Rv3497c, (MTV023.04c), len: 357 aa. mce4C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); and O53969|Rv1968|MTV051.06|mce3C (410 aa). Also similar to others e.g. Q9F358|SC8A2.05c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (351 aa), FASTA scores: opt: 658, E(): 1.1e-30, (33.95% identity in 318 aa overlap); Q9CD12|MCE1C|ML2591 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (519 aa), FASTA scores: opt: 555, E(): 1.2e-24, (28.35% identity in 328 aa overlap); etc. Hydrophobic region at N-terminus. TBparse score is 0.889.; MCE-family protein MCE4C	complement(3915883..3916956)	Mycobacterium tuberculosis H37Rv	888354
NP_218015.1	CDS	mce4B	NC_000962.2	3916946	3917998	R	Rv3498c, (MTV023.05c), len: 350 aa. mce4B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); and O53968|Rv1967|MTV051.05|mce3B (342 aa). Also similar to others e.g. Q9CD13|MCE1B|ML2590 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (346 aa), FASTA scores: opt: 803, E(): 6.1e-41, (41.05% identity in 346 aa overlap); Q9F357|SC8A2.06c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (354 aa), FASTA scores: opt: 624, E(): 3.4e-30, (32.55% identity in 338 aa overlap); etc. Hydrophobic region at N-terminus. TBparse score is 0.878.; MCE-family protein MCE4B	complement(3916946..3917998)	Mycobacterium tuberculosis H37Rv	888349
YP_177977.1	CDS	mce4A	NC_000962.2	3917998	3919200	R	Rv3499c, (MTV023.06c), len: 400 aa. mce4A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); and O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar to others e.g. Q9F356|SC8A2.07c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (418 aa), FASTA scores: opt: 619, E(): 7.8e-30, (32.4% identity in 352 aa overlap); Q9S4U5|MCE1 MYCOBACTERIAL CELL ENTRY PROTEIN from Mycobacterium bovis BCG (454 aa), FASTA scores: opt: 529, E(): 2.1e-24, (30.35% identity in 448 aa overlap); Q9CD14|MCE1A|ML2589 from Mycobacterium leprae (441 aa), FASTA scores: opt: 515, E(): 1.4e-23, (28.35% identity in 430 aa overlap); etc. Contains a possible N-terminal signal sequence. TBparse score is 0.914. Note that previously known as mce4.; mce4; MCE-family protein MCE4A	complement(3917998..3919200)	Mycobacterium tuberculosis H37Rv	888344
NP_218017.1	CDS	yrbE4B	NC_000962.2	3919220	3920062	R	Rv3500c, (MTV023.07c), len: 280 aa. yrbE4B, hypothetical unknown integral membrane protein, part of mce4 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); and O53966|Rv1965|MTV051.03|yrbE3B (271 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD15|YRBE1B|ML2588 from Mycobacterium leprae (289 aa), FASTA scores: opt: 973, E(): 1.5e-50, (50.2% identity in 269 aa overlap); P45030|YRBE_HAEIN|HI1086 from Haemophilus influenzae (261 aa), FASTA scores: opt: 270, E(): 6e-11, (25.4% identity in 264 aa overlap); etc. TBparse score is 0.887.; integral membrane protein YrbE4b	complement(3919220..3920062)	Mycobacterium tuberculosis H37Rv	888336
NP_218018.1	CDS	yrbE4A	NC_000962.2	3920097	3920861	R	Rv3501c, (MTV023.08c), len: 254 aa. yrbE4A, hypothetical unknown integral membrane protein, part of mce4 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); and O53965|Rv1964|MTV051.02|yrbE3A (265 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD16|YRBE1A|ML2587 from Mycobacterium leprae (267 aa), FASTA scores: opt: 1059, E(): 1e-57, (64.75% identity in 247 aa overlap); P45030|YRBE_HAEIN|HI1086 from Haemophilus influenzae (261 aa), FASTA scores: opt: 313, E(): 3e-14, (25.7% identity in 241 aa overlap); etc. TBparse score is 0.900.; integral membrane protein YrbE4a	complement(3920097..3920861)	Mycobacterium tuberculosis H37Rv	888320
NP_218019.1	CDS	fabG	NC_000962.2	3921087	3922040	R	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase	complement(3921087..3922040)	Mycobacterium tuberculosis H37Rv	887697
NP_218020.1	CDS	fdxD	NC_000962.2	3922065	3922256	R	Rv3503c, (MTV023.10c), len: 63 aa. Probable fdxD, ferredoxin, equivalent to Q9R6Z5|B229_C3_226 HYPOTHETICAL 9.3 KDA PROTEIN from Mycobacterium leprae (83 aa) FASTA scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa overlap). Also similar to several e.g. Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); Q9X4X8|DITA3 DIOXYGENASE DITA FERREDOXIN COMPONENT from Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166, E(): 1.4e-05, (36.2% identity in 58 aa overlap); P00203|FER_MOOTH from Moorella thermoacetica (Clostridium thermoaceticum) (63 aa), FASTA scores: opt: 157, E(): 5.4e-05, (36.65% identity in 60 aa overlap); P18325|FER2_STRGO|SUBB from Streptomyces griseolus (64 aa) FASTA scores: opt: 157, E(): 5.5e-05, (39.35% identity in 61 aa overlap); etc. BELONGS TO THE BACTERIAL TYPE FERREDOXIN FAMILY. TBparse score is 0.871.; ferredoxin FdxD	complement(3922065..3922256)	Mycobacterium tuberculosis H37Rv	888311
NP_218021.1	CDS	fadE26	NC_000962.2	3922471	3923673	D	Rv3504, (MTV023.11), len: 400 aa. Probable fadE26, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to other ACYL-CoA DEHYDROGENASES from Mycobacterium tuberculosis e.g. P71858|FADE29|Rv3543c|MTCY03C7.13 (387 aa) FASTA scores: opt: 1031, E(): 7.5e-59, (46.25% identity in 402 aa overlap); and P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa), FASTA scores: opt: 617, E(): 3.1e-32, (32.6% identity in 423 aa overlap); etc. Also similar to others e.g. Q9A6G3|CC2131 from Caulobacter crescentus (403 aa) FASTA scores: opt: 710, E(): 3.2e-38, (33.4% identity in 413 aa overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 522, E(): 3.7e-26, (34.1% identity in 358 aa overlap); Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa), FASTA scores: opt: 509, E(): 2.6e-25, (34.45% identity in 363 aa overlap); etc. COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.885.; acyl-CoA dehydrogenase FADE26	3922471..3923673	Mycobacterium tuberculosis H37Rv	887722
NP_218022.1	CDS	fadE27	NC_000962.2	3923698	3924819	D	Rv3505, (MTV023.12), len: 373 aa. Probable fadE27, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to other ACYL-CoA DEHYDROGENASES from Mycobacterium tuberculosis e.g. P71857|FADE28|Rv3544c|MTCY03C7.12 (339 aa) FASTA scores: opt: 497, E(): 1.8e-22, (30.3% identity in 343 aa overlap); and P95281|FADE18|Rv1933c|MTCY09F9.31 (363 aa) FASTA scores: opt: 421, E(): 6.4e-18, (32.35% identity in 334 aa overlap). Also similar to other e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 425, E(): 3.5e-18, (30.75% identity in 351 aa overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa) FASTA scores: opt: 317, E(): 1e-11, (32.8% identity in 372 aa overlap); Q9L8Q3|PDTORFO from Pseudomonas stutzeri (Pseudomonas perfectomarina) (513 aa), FASTA scores: opt: 301, E(): 1.2e-10, (25.9% identity in 394 aa overlap); etc. COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.888.; acyl-CoA dehydrogenase FADE27	3923698..3924819	Mycobacterium tuberculosis H37Rv	888248
NP_218023.1	CDS	fadD17	NC_000962.2	3924890	3926398	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	3924890..3926398	Mycobacterium tuberculosis H37Rv	888251
YP_177978.1	CDS	PE_PGRS53	NC_000962.2	3926569	3930714	D	Rv3507, (MTV023.14), len: 1381 aa. Member of the Mycobacterium tuberculosis PE protein family, PGRS subfamily of gly-rich proteins (see citation below), similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O06810|Rv1450c|MTCY493.04 (1329 aa), FASTA scores: opt: 2173, E(): 1.4e-135, (51.15% identity in 1412 aa overlap). Equivalent to AAK47970 from Mycobacterium tuberculosis strain CDC1551 (1384 aa) but with some minor differences between the proteins. Contains two PS00583 pfkB family of carbohydrate kinases signatures 1.; PE-PGRS family protein	3926569..3930714	Mycobacterium tuberculosis H37Rv	888256
YP_177979.1	CDS	PE_PGRS54	NC_000962.2	3931005	3936710	D	Rv3508, (MTV023.15), len: 1901 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002), similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. downstream O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 6598, E(): 0, (71.05% identity in 1533 aa overlap). Equivalent to AAK47971 from Mycobacterium tuberculosis strain CDC1551 (1384 aa) but shorter 13 aa and with some minor differences between the proteins. Contains five PS00583 pfkB family of carbohydrate kinases signatures 1.; PE-PGRS family protein	3931005..3936710	Mycobacterium tuberculosis H37Rv	888270
NP_218026.1	CDS	ilvX	NC_000962.2	3936877	3938424	R	thiamine-pyrophosphate requiring enzyme; hypothetical protein	complement(3936877..3938424)	Mycobacterium tuberculosis H37Rv	888267
NP_218027.1	CDS	Rv3510c	NC_000962.2	3938421	3939257	R	Rv3510c, (MTV023.17), len: 278 aa. Conserved hypothetical protein, similar to Q50662|Rv2303c|MTCY339.06 HYPOTHETICAL 34.6 KDA PROTEIN from Mycobacterium tuberculosis (307 aa), FASTA scores: opt: 416, E(): 1.2e-19, (35.7% identity in 255 aa overlap). Middle of the putative protein highly similar to N-terminal end of Q49860|B229_C2_182 HYPOTHETICAL 11.0 KDA PROTEIN from Mycobacterium leprae (95 aa), FASTA scores: opt: 304, E(): 7.9e-13, (83.65% identity in 55 aa overlap). Also some similarity with other bacterial proteins e.g. P95886 ORF C02006 from Sulfolobus solfataricus (269 aa), FASTA scores: opt: 293, E(): 9.6e-12, (31.3% identity in 198 aa overlap); Q9XDF3|NONC NONC PROTEIN from Streptomyces griseus subsp. griseus (317 aa), FASTA scores: opt: 270, E(): 3.4e-10, (29.95% identity in 227 aa overlap); Q54229|NONR MACROTETROLIDE ANTIBIOTIC-RESISTANCE PROTEIN from Streptomyces griseus (347 aa), FASTA scores: opt: 270, E(): 3.6e-10, (29.95% identity in 227 aa overlap); etc. TBparse score is 0.907.; hypothetical protein	complement(3938421..3939257)	Mycobacterium tuberculosis H37Rv	888298
YP_177980.1	CDS	PE_PGRS55	NC_000962.2	3939617	3941761	D	Rv3511, (MTV023.18), len: 714 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 2563, E(): 1.5e-94, (59.65% identity in 773 aa overlap); and upstream O53553|Rv3508|MTV023.15 (1901 aa), FASTA scores: opt: 2455, E(): 3.9e-90, (60.4% identity in 737 aa overlap); etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1.; PE-PGRS family protein	3939617..3941761	Mycobacterium tuberculosis H37Rv	888273
YP_177981.1	CDS	PE_PGRS56	NC_000962.2	<3941724	3944963	D	Rv3512, (MTV023.19), len: 1059 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 3688, E(): 4.5e-130, (53.95% identity in 1136 aa overlap); and downstream O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 3611, E(): 3.6e-127, (53.15% identity in 1195 aa overlap); etc. Frameshifted PGRS protein, could be continuation of upstream MTV023.18, but no error could be found.; PE-PGRS family protein	<3941724..3944963	Mycobacterium tuberculosis H37Rv	888306
NP_218030.1	CDS	fadD18	NC_000962.2	3945092	3945748	R	Rv3513c, (MTV023.20c), len: 218 aa (Start uncertain). Probable fadD18, fatty-acid-CoA synthetase (C-terminal fragment) (EC 6.2.1.-), almost identical to C-terminal end of downstream O53560|FADD19|Rv3515c|MTV023.22c, probably result of partial gene duplication. Also similar at the C-terminus to other fatty-acid-CoA synthetases e.g. Q9EXL2|FADD from Streptomyces griseus (540 aa), FASTA scores: opt: 586, E(): 1.2e-28, (52.45% identity in 185 aa overlap); AAB87139|MIG MEDIUM CHAIN ACYL-CoA SYNTHETASE PRECURSOR from Mycobacterium avium (550 aa), FASTA scores: opt: 506, E(): 9.5e-24, (50.0% identity in 150 aa overlap); Q9A7C3|CC1801 PUTATIVE 4-COUMARATE--CoA LIGASE from Caulobacter crescentus (561 aa), FASTA scores: opt: 430, E(): 4.4e-19, (45.75% identity in 153 aa overlap); Q9KDT0|BH1131 ACID-CoA LIGASE from Bacillus halodurans (546 aa), FASTA scores: opt: 338, E(): 1.9e-13, (38.05% identity in 142 aa overlap); Q9RTR4|DR1692 LONG-CHAIN FATTY ACID--CoA LIGASE from Deinococcus radiodurans (584 aa), FASTA scores: opt: 331, E(): 5.3e-13, (35.15% identity in 145 aa overlap); etc.; fatty-acid-CoA ligase	complement(3945092..3945748)	Mycobacterium tuberculosis H37Rv	888277
YP_177982.1	CDS	PE_PGRS57	NC_000962.2	3945794	3950263	D	Rv3514, (MTV023.21), len: 1489 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47971 (1715 aa) FASTA scores: opt: 6940, E(): 0, (67.0% identity in 1713 aa overlap); and upstream O53553|YZ08_MYCTU|Rv3508|MTV023.15 (1901 aa), FASTA scores: opt: 6598,E(): 0, (71.05% identity in 1533 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. TBparse score is 0.838.; PE-PGRS family protein	3945794..3950263	Mycobacterium tuberculosis H37Rv	888294
YP_177983.1	CDS	fadD19	NC_000962.2	3950824	3952470	R	activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase	complement(3950824..3952470)	Mycobacterium tuberculosis H37Rv	888275
NP_218033.1	CDS	echA19	NC_000962.2	3952544	3953335	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	3952544..3953335	Mycobacterium tuberculosis H37Rv	888301
NP_218034.1	CDS	Rv3517	NC_000962.2	3953431	3954270	D	Rv3517, (MTV023.24), len: 279 aa. Hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. P71763|Rv1482c|MTCY277.03c from Mycobacterium tuberculosis strain H37Rv (339 aa) (alias AAK45794|MT1529 from Mycobacterium tuberculosis strain CDC1551 (292 aa) but longer) FASTA scores: opt: 1040, E(): 3.7e-60, (59.0% identity in 273 aa overlap); O07396|MAV346 from Mycobacterium avium (346 aa) FASTA scores: opt: 1018, E(): 1e-58, (57.2% identity in 278 aa overlap); O53421|Rv1073|MTV017.26 from Mycobacterium tuberculosis strain H37Rv (283 aa), FASTA scores: opt: 903, E(): 2.4e-51, (48.0% identity in 277 aa overlap); Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa) FASTA scores: opt: 158, E(): 0.0015, (41.8% identity in 55 aa overlap); etc. TBparse score is 0.910.; hypothetical protein	3953431..3954270	Mycobacterium tuberculosis H37Rv	888284
NP_218035.1	CDS	cyp142	NC_000962.2	3954325	3955521	R	Rv3518c, (MTV023.25c), len: 398 aa. Probable cyp142, cytochrome P450 monoxygenase (EC 1.14.-.-), member of Cytochrome P450 family and similar to many e.g. Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FASTA scores: opt: 798, E(): 2e-43, (36.7% identity in 403 aa overlap); P33271|CPXK_SACER|CYP107B1 from Saccharopolyspora erythraea (Streptomyces erythraeus) (405 aa), FASTA scores: opt: 725, E(): 9.1e-39, (37.1% identity in 407 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor (411 aa), FASTA scores: opt: 691, E(): 1.3e-36, (37.2% identity in 317 aa overlap); etc. Also similar to Q50696|C124_MYCTU|CYP124|Rv2266|MT2328|MTCY339.44c from Mycobacterium tuberculosis strain H37Rv (428 aa) FASTA scores: opt: 692, E(): 1.2e-36, (36.8% identity in 402 aa overlap). Equivalent to AAK47979 from Mycobacterium tuberculosis strain CDC1551 (372 aa) but longer 26 aa. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY. TBparse score is 0.891.; cytochrome P450 monooxygenase 142	complement(3954325..3955521)	Mycobacterium tuberculosis H37Rv	888282
NP_218036.1	CDS	Rv3519	NC_000962.2	3955550	3956260	D	Rv3519, (MTV023.26), len: 236 aa (start uncertain). Hypothetical unknown protein. The C-terminal end is highly similar to N-terminal end of AAK47980|MT3620 HYPOTHETICAL 7.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (73 aa), FASTA scores: opt: 279, E(): 9.4e-12, (95.65% identity in 46 aa overlap). TBparse score is 0.897.; hypothetical protein	3955550..3956260	Mycobacterium tuberculosis H37Rv	887247
NP_218037.1	CDS	Rv3520c	NC_000962.2	3956325	3957368	R	Rv3520c, (MTV023.27c), len: 347 aa. Possible coenzyme F420-dependent oxidoreductase (EC 1.-.-.-), equivalent to Q9CCV8|ML0348 POSSIBLE COENZYME F420-DEPENDENT OXIDOREDUCTASE from Mycobacterium leprae (350 aa), FASTA scores: opt: 2029, E(): 9.1e-120, (86.85% identity in 342 aa overlap). Similar to many coenzyme F420-dependent enzymes (and other proteins) e.g. Q9AD98|SCI52.11c PUTATIVE ATP/GTP-BINDING PROTEIN from Streptomyces coelicolor (351 aa), FASTA scores: opt: 859, E(): 1.6e-46, (41.9% identity in 346 aa overlap); Q9X7Y1|SC6A5.35 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (341 aa), FASTA scores: opt: 800, E(): 7.9e-43, (38.95% identity in 339 aa overlap); Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces violaceoruber (343 aa), FASTA scores: opt: 354, E(): 6.7e-15, (34.2% identity in 336 aa overlap); Q49598|MER COENZYME F420-DEPENDENT N5,N10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from Methanopyrus kandleri (349 aa), FASTA scores: opt: 283, E(): 1.9e-10, (26.75% identity in 329 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from Methanococcus jannaschii (331 aa), FASTA scores: opt: 227, E(): 5.8e-07, (26.35% identity in 334 aa overlap); O27784|MTH1752 COENZYME F420-DEPENDENT N5,N10-METHYLENE TETRAHYDROMETHANOPTERIN REDUCTASE from Methanobacterium thermoautotrophicum (321 aa), FASTA scores: opt: 207, E(): 1e-05, (27.4% identity in 336 aa overlap); etc. Also similar to Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 HYPOTHETICAL 37.3 KDA PROTEIN from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 313, E(): 2.5e-12, (28.0% identity in 311 aa overlap). TBparse score is 0.890.; coenzyme F420-dependent oxidoreductase	complement(3956325..3957368)	Mycobacterium tuberculosis H37Rv	887310
NP_218038.1	CDS	Rv3521	NC_000962.2	3957521	3958432	D	Rv3521, (MTV023.28), len: 303 aa. Conserved hypothetical protein, similar to (although longer than) other conserved hypothetical proteins e.g. O29296|AF0966 from Archaeoglobus fulgidus (176 aa), FASTA scores: opt: 286, E(): 5.4e-11, (31.15% identity in 170 aa overlap); O30036|AF0203 from Archaeoglobus fulgidus (149 aa) FASTA scores: opt: 259, E(): 2.3e-09, (33.8% identity in 142 aa overlap); O29297|AF0965 from Archaeoglobus fulgidus (154 aa), FASTA scores: opt: 241, E(): 3.2e-08, (31.4% identity in 137 aa overlap); Q9Y995|APE2390 from Aeropyrum pernix (157 aa), FASTA scores: opt: 204, E(): 6.8e-06, (27.45% identity in 153 aa overlap); BAB60424|TVG1322512 from Thermoplasma volcanium (164 aa), FASTA scores: opt: 183, E(): 0.00015, (29.75% identity in 148 aa overlap); etc. Equivalent to AAK47982 from Mycobacterium tuberculosis strain CDC1551 (334 aa) but shorter 31 aa. TBparse score is 0.884.; hypothetical protein	3957521..3958432	Mycobacterium tuberculosis H37Rv	887209
NP_218039.1	CDS	ltp4	NC_000962.2	3958448	3959512	D	Rv3522, (MTV023.29), len: 354 aa. Possible ltp4, lipid carrier protein or keto acyl-CoA thiolase (EC 2.3.1.16), similar to several e.g. O30103|AF0134 3-KETOACYL-CoA THIOLASE (ACAB-4) from Archaeoglobus fulgidus (398 aa) FASTA scores: opt: 352, E(): 5.3e-15, (30.45% identity in 381 aa overlap); O29295|AF0967 3-KETOACYL-CoA THIOLASE (ACAB-9) from Archaeoglobus fulgidus (400 aa) FASTA scores: opt: 312, E(): 1.8e-12, (28.05% identity in 367 aa overlap); O29294|AF0968 3-KETOACYL-CoA THIOLASE (ACAB-10) from Archaeoglobus fulgidus (388 aa), FASTA scores: opt: 293, E(): 2.9e-11, (25.9% identity in 309 aa overlap); O58409|PH0676 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER PROTEIN (ACETHYL CoA SYNTHETASE) (EC 6.2.1.-) from Pyrococcus horikoshii (389 aa), FASTA scores: opt: 292, E(): 3.3e-11, (25.8% identity in 368 aa overlap); Q9Y9A3|APE2382 LONG HYPOTHETICAL NON SPECIFIC LIPID-TRANSFER PROTEIN from Aeropyrum pernix (360 aa) FASTA scores: opt: 270, E(): 7.8e-10, (27.25% identity in 363 aa overlap); Q9YDI4|APE0929 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER PROTEIN from Aeropyrum pernix (400 aa), FASTA scores: opt: 258, E(): 4.9e-09, (26.45% identity in 306 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.896.; lipid-transfer protein	3958448..3959512	Mycobacterium tuberculosis H37Rv	887885
NP_218040.1	CDS	ltp3	NC_000962.2	3959529	3960713	D	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase	3959529..3960713	Mycobacterium tuberculosis H37Rv	888247
NP_218041.1	CDS	Rv3524	NC_000962.2	3960755	3961786	D	Rv3524, (MTCY03C7.32c), len: 343 aa. Probable conserved membrane protein, showing some similarity to C-terminal part of putative Mycobacterium tuberculosis proteins O05871|P95308|PKND_MYCTU|Rv0931c|MT0958|MTCY08C9.08 serine-threonine protein kinase PknD (EC 2.7.1.-) (664 aa) FASTA scores: opt: 727, E(): 8.3e-36, (45.3% identity in 298 aa overlap); O53893|Rv0980c|MTV044.08c PGRS-FAMILY PROTEIN (457 aa), FASTA scores: opt: 208, E(): 4.4e-05, (33.75% identity in 166 aa overlap); and O53891|Rv0978c|MTV044.06c PGRS-FAMILY PROTEIN (331 aa) FASTA scores: opt: 153, E(): 0.062, (30.75% identity in 117 aa overlap). Contains PS00237 G-protein coupled receptors signature.; hypothetical protein	3960755..3961786	Mycobacterium tuberculosis H37Rv	888250
NP_218042.1	CDS	Rv3525c	NC_000962.2	3961800	3962324	R	Rv3525c, (MTCY3C7.31), len: 174 aa. Possible siderophore-binding protein, similar to ferripyochelin binding proteins (and related) e.g. Q9RSN5|DR2089 FERRIPYOCHELIN-BINDING PROTEIN from Deinococcus radiodurans (240 aa), FASTA scores: opt: 472, E(): 3.3e-21, (46.9% identity in 162 aa overlap); O59257|PH1591 LONG HYPOTHETICAL FERRIPYOCHELIN BINDING PROTEIN from Pyrococcus horikoshii (173 aa), FASTA scores: opt: 431, E(): 6.7e-19, (40.0% identity in 170 aa overlap); Q9V158|FBP|PAB0393 FERRIPYOCHELIN BINDING PROTEIN from Pyrococcus abyssi (173 aa), FASTA scores: opt: 429, E(): 8.9e-19, (39.4% identity in 170 aa overlap); BAB47820|MLR0180 FERRIPYOCHELIN BINDING PROTEIN-LIKE from Rhizobium loti (Mesorhizobium loti) (175 aa), FASTA scores: opt: 415, E(): 6.1e-18, (42.55% identity in 141 aa overlap); etc.; siderophore-binding protein	complement(3961800..3962324)	Mycobacterium tuberculosis H37Rv	888255
NP_218043.1	CDS	Rv3526	NC_000962.2	3962439	3963599	D	Rv3526, (MTCY03C7.30c), len: 386 aa. Hypothetical oxidoreductase (EC 1.-.-.-), highly similar, except in C-terminus (also longer 69 aa), to O69348|ORF12 PROTEIN (function unknown) from Rhodococcus erythropolis (316 aa) FASTA scores: opt: 1137, E(): 6.9e-65, (59.6% identity in 250 aa overlap). Also some similarity with several aminopyrrolnitrin oxidases (PRND proteins, involved in the pathway for pyrrolnitrin biosynthesis, a secondary metabolite derived from tryptophan which has strong anti-fungal activity) e.g. Q9RPG0|PRND from Myxococcus fulvus (379 aa), FASTA scores: opt: 322, E(): 4.4e-13, (25.85% identity in 352 aa overlap); Q9RPG4|PRND from Burkholderia cepacia (Pseudomonas cepacia) (373 aa) FASTA scores: opt: 306, E(): 4.5e-12, (25.2% identity in 373 aa overlap); P95483|PRND from Pseudomonas fluorescens (363 aa), FASTA scores: opt: 305, E(): 5.1e-12, (25.0% identity in 372 aa overlap); etc. And also some similarity to other putative enzymes like dioxygenases, oxidases, vanillate O-demethyl oxygenase, etc.; oxidoreductase	3962439..3963599	Mycobacterium tuberculosis H37Rv	888268
NP_218044.1	CDS	Rv3527	NC_000962.2	3963605	3964054	D	Rv3527, (MTCY03C7.29c), len: 149 aa. Hypothetical unknown protein.; hypothetical protein	3963605..3964054	Mycobacterium tuberculosis H37Rv	888295
NP_218045.1	CDS	Rv3528c	NC_000962.2	3964479	3965192	R	Rv3528c, (MTCY03C7.28), len: 237 aa. Hypothetical unknown protein.; hypothetical protein	complement(3964479..3965192)	Mycobacterium tuberculosis H37Rv	888297
NP_218046.1	CDS	Rv3529c	NC_000962.2	3965884	3967038	R	Rv3529c, (MTCY03C7.27), len: 384 aa. Conserved hypothetical protein, showing some similarity to Q50695|YM67_MYCTU|Rv2267c|MT2329|MTCY339.43 HYPOTHETICAL 46.1 KDA PROTEIN from Mycobacterium tuberculosis (388 aa) FASTA scores: opt: 261, E(): 1.6e-09, (27.25% identity in 253 aa overlap).; hypothetical protein	complement(3965884..3967038)	Mycobacterium tuberculosis H37Rv	888324
NP_218047.1	CDS	Rv3530c	NC_000962.2	3967038	3967820	R	Rv3530c, (MTCY03C7.26), len: 260 aa. Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases and hypothetical proteins e.g. BAB53258|Q987E5|MLL7083 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: opt: 405, E(): 5.3e-18, (33.45% identity in 263 aa overlap); Q9VNF3|CG12171 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (257 aa), FASTA scores: opt: 404, E(): 6.1e-18, (32.8% identity in 256 aa overlap); Q9A3X5|CC3076 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Caulobacter crescentus (254 aa), FASTA scores: opt: 400, E(): 1.1e-17, (31.0% identity in 255 aa overlap); BAB50080|MLR3115 DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (259 aa), FASTA scores: opt: 393, E(): 3e-17, (31.9% identity in 254 aa overlap); Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE 3-KETO-ACYL-REDUCTASE from Streptomyces antibioticus (273 aa), FASTA scores: opt: 388, E(): 6.3e-17, (31.6% identity in 250 aa overlap); etc.; short chain dehydrogenase	complement(3967038..3967820)	Mycobacterium tuberculosis H37Rv	888338
NP_218048.1	CDS	Rv3531c	NC_000962.2	3967817	3968944	R	Rv3531c, (MTCY03C7.25), len: 375 aa. Hypothetical unknown protein.; hypothetical protein	complement(3967817..3968944)	Mycobacterium tuberculosis H37Rv	888348
YP_177984.1	CDS	PPE61	NC_000962.2	3969343	3970563	D	Rv3532, (MTCY03C7.24c), len: 406 aa. Member of the Mycobacterium tuberculosis PPE protein family, similar to many, e.g. O53956|Rv1807|MTV049.29 (403 aa), FASTA scores: opt: 954, E(): 1.1e-43, (44.1% identity in 417 aa overlap); PPE family protein	3969343..3970563	Mycobacterium tuberculosis H37Rv	888370
YP_177985.1	CDS	PPE62	NC_000962.2	3970705	3972453	R	Rv3533c, (MTCY03C7.23), len: 582 aa. Member of the Mycobacterium tuberculosis PPE protein family, similar to many, e.g. O53309|Rv3159c|MTV014.03c (590 aa) FASTA scores: opt: 2289, E(): 2.3e-95, (63.5% identity in 600 aa overlap).; PPE family protein	complement(3970705..3972453)	Mycobacterium tuberculosis H37Rv	888385
NP_218051.1	CDS	Rv3534c	NC_000962.2	3972552	3973592	R	catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase	complement(3972552..3973592)	Mycobacterium tuberculosis H37Rv	888387
NP_218052.1	CDS	Rv3535c	NC_000962.2	3973589	3974500	R	catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase	complement(3973589..3974500)	Mycobacterium tuberculosis H37Rv	888396
NP_218053.1	CDS	Rv3536c	NC_000962.2	3974511	3975296	R	Rv3536c, (MTCY03C7.20), len: 261 aa. Probable hydratase, 2-oxo-hepta-3-ene-1,7-dioate hydratase (EC 4.2.1.-) or 2-keto-4-pentenoate hydratase (EC 4.2.1.-). Indeed, highly similar to many 2-oxo-hepta-3-ene-1,7-dioate hydratases e.g. Q9CKS2|HPAH|PM1534 from Pasteurella multocida (267 aa) FASTA scores: opt: 743, E(): 1.5e-39, (45.5% identity in 266 aa overlap) Q9RZ31|DRA0122 from Deinococcus radiodurans (268 aa), FASTA scores: opt: 709, E(): 2e-37, (45.5% identity in 266 aa overlap); Q9HWQ4|HPCG|PA4127 from Pseudomonas aeruginosa (267 aa), FASTA scores: opt: 703, E(): 4.8e-37, (45.1% identity in 266 aa overlap); Q46982|HPAH|HPCG from Escherichia colis strain ATCC 11105 (267 aa), FASTA scores: opt: 679, E(): 1.6e-35, (41.35% identity in 266 aa overlap); etc. But also highly similar to many 2-keto-4-pentenoate hydratases (2-hydroxypentadienoic acidhydratases) e.g. Q9LAF7|PHED from Bacillus thermoglucosidasius (258 aa), FASTA scores: opt: 698, E(): 9.7e-37, (42.45% identity in 252 aa overlap); Q52442|BPHH from Pseudomonas sp (260 aa) FASTA scores: opt: 675, E(): 2.7e-35, (41.4% identity in 251 aa overlap); P77608|MHPD_ECOLI|B0350 from Escherichia coli strain K12 (269 aa), FASTA scores: opt: 674, E(): 3.2e-35, (42.75% identity in 255 aa overlap); Q52038|BPHX1 from Pseudomonas pseudoalcaligenes (260 aa), FASTA scores: opt: 663, E(): 1.5e-34, (40.6% identity in 251 aa overlap); etc.; hydratase	complement(3974511..3975296)	Mycobacterium tuberculosis H37Rv	888406
NP_218054.1	CDS	Rv3537	NC_000962.2	3975369	3977060	D	initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase	3975369..3977060	Mycobacterium tuberculosis H37Rv	888422
YP_177986.1	CDS	Rv3538	NC_000962.2	3977062	3977922	D	Rv3538, (MTCY03C7.18c), len: 286 aa. Probable dehydrogenase (EC 1.-.-.-), similar to Q9L009|SCC30.12c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (333 aa), FASTA scores: opt: 842, E(): 3.6e-44, (48.4% identity in 285 aa overlap); and similar to C-terminal part of other (principally ESTRADIOL 17 BETA-DEHYDROGENASES/17-BETA-HYDROXYSTEROID DEHYDROGENASES) e.g. P70540 PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE II (SDR FAMILY) from Rattus norvegicus (Rat) (735 aa) FASTA scores: opt: 622, E(): 1.9e-30, (37.45% identity in 283 aa overlap); or P70523|MPF-2 MULTIFUNCTIONAL PROTEIN 2 (SDR FAMILY) (beta-oxidation protein displaying 2-enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity) from Rattus norvegicus (Rat) (734 aa), FASTA scores: opt: 616, E(): 4.3e-30, (37.1% identity in 283 aa overlap); P51659|DHB4_HUMAN|HSD17B4|EDH17B4 ESTRADIOL 17 BETA-DEHYDROGENASE (EC 1.1.1.62) from Homo sapiens (Human) (736 aa), FASTA scores: opt: 614, E(): 5.7e-30, (35.9% identity in 284 aa overlap); P97852|DHB4_RAT|HSD17B4|EDH17B4 ESTRADIOL 17 BETA-DEHYDROGENASE from Rattus norvegicus (Rat) (735 aa) FASTA scores: opt: 613, E(): 6.6e-30, (37.1% identity in 283 aa overlap); Q9DBM3|HSD17B4 ESTRADIOL 17 BETA-DEHYDROGENASE from Mus musculus (Mouse) (735 aa) FASTA scores: opt: 611, E(): 8.7e-30, (36.5% identity in 285 aa overlap); etc. Also similar to Q11198|Rv3389c|MTV004.47c HYPOTHETICAL 30.3 KDA PROTEIN from Mycobacterium tuberculosis (290 aa), FASTA scores: opt: 609, E(): 5.3e-30, (39.65% identity in 285 aa overlap). Note that previously known as ufaA2.; ufaA2; dehydrogenase	3977062..3977922	Mycobacterium tuberculosis H37Rv	888426
YP_177987.1	CDS	PPE63	NC_000962.2	3978059	3979498	D	Rv3539, (MTCY03C7.17c), len: 479 aa. Member of the Mycobacterium tuberculosis PPE protein family, similar to many e.g. O53949|Rv1800|MTV049.22 (655 aa), FASTA scores: opt: 914, E(): 7.3e-47, (37.55% identity in 490 aa overlap); etc.; PPE family protein	3978059..3979498	Mycobacterium tuberculosis H37Rv	888438
NP_218057.1	CDS	ltp2	NC_000962.2	3979499	3980659	R	Rv3540c, (MTCY03C7.16), len: 386 aa. Probable ltp2, lipid-transfer protein or keto acyl-CoA thiolase (EC 2.3.1.16), similar to several e.g. Q9X4X2|DITF DITF PROTEIN (hypothetical protein, similar to non-specific lipid-transfer protein and 3-ketoacyl-CoA thiolase) from Pseudomonas abietaniphila (397 aa), FASTA scores: opt: 665, E(): 5.3e-34, (33.4% identity in 392 aa overlap); O30255|AF2416 3-KETOACYL-CoA THIOLASE (ACAB-12) from Archaeoglobus fulgidus (384 aa), FASTA scores: opt: 496, E(): 1.6e-23, (30.35% identity in 389 aa overlap); O28978|AF1291 3-KETOACYL-CoA THIOLASE (ACAB-11) from Archaeoglobus fulgidus (392 aa), FASTA scores: opt: 494, E(): 2.2e-23, (30.6% identity in 379 aa overlap); O26884|MTH793 LIPID-TRANSFER PROTEIN (STEROL OR NONSPECIFIC) from Methanobacterium thermoautotrophicum (383 aa), FASTA scores: opt: 487, E(): 5.9e-23, (30.4% identity in 388 aa overlap); etc.; lipid-transfer protein	complement(3979499..3980659)	Mycobacterium tuberculosis H37Rv	888450
NP_218058.1	CDS	Rv3541c	NC_000962.2	3980659	3981048	R	Rv3541c, (MTCY03C7.15), len: 129 aa. Hypothetical protein, showing some similarity to Q9CBJ7|ML1909 HYPOTHETICAL PROTEIN from Mycobacterium leprae (142 aa) FASTA scores: opt: 110, E(): 1.2, (27.95% identity in 118 aa overlap); and other (see also BLASTP results) e.g. Q9L0M3|SCD82.08 HYPOTHETICAL 15.2 KDA PROTEIN from Streptomyces coelicolor (142 aa), FASTA scores: opt: 127, E(): 0.086, (27.65% identity in 123 aa overlap). Contains PS00075 Dihydrofolate reductase signature.; hypothetical protein	complement(3980659..3981048)	Mycobacterium tuberculosis H37Rv	888475
NP_218059.1	CDS	Rv3542c	NC_000962.2	3981045	3981980	R	Rv3542c, (MTCY03C7.14), len: 311 aa. Hypothetical protein, showing some similarity to other e.g. Q58947|MJ1552 from Methanococcus jannaschii (141 aa) FASTA scores: opt: 177, E(): 0.00065, (46.65% identity in 60 aa overlap); BAB59276|TVG0142586 from Thermoplasma volcanium (135 aa), FASTA scores: opt: 175, E(): 0.00083, (35.65% identity in 87 aa overlap); Q9HI85|TA1457 from Thermoplasma acidophilum (135 aa), FASTA scores: opt: 162, E(): 0.0052, (31.8% identity in 107 aa overlap); etc.; hypothetical protein	complement(3981045..3981980)	Mycobacterium tuberculosis H37Rv	888486
NP_218060.1	CDS	fadE29	NC_000962.2	3981977	3983140	R	Rv3543c, (MTCY03C7.13), len: 387 aa. Probable fadE29, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9A8P3|CC1310 from Caulobacter crescentus (404 aa), FASTA scores: opt: 624, E(): 9.4e-32, (32.75% identity in 400 aa overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 550, E(): 3.9e-27, (33.7% identity in 350 aa overlap); O28976|AF1293 from Archaeoglobus fulgidus (384 aa), FASTA scores: opt: 529, E(): 8.1e-26, (30.0% identity in 393 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. O53549|FADE26|Rv3504|MTV023.11 (400 aa), FASTA scores: opt: 1031, E(): 2.8e-57, (46.0% identity in 402 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE29	complement(3981977..3983140)	Mycobacterium tuberculosis H37Rv	888131
NP_218061.1	CDS	fadE28	NC_000962.2	3983125	3984144	R	Rv3544c, (MTCY03C7.12), len: 339 aa. Probable fadE28, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FASTA scores: opt: 334, E(): 5.1e-13, (27.65% identity in 329 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 278, E(): 1.2e-09, (26.95% identity in 319 aa overlap); O29813|AF0436 from Archaeoglobus fulgidus (382 aa) FASTA scores: opt: 205, E(): 3.5e-05, (24.75% identity in 384 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. O53550|FADE27|Rv3505|MTV023.12 (373 aa) FASTA scores: opt: 497, E(): 7e-23, (30.3% identity in 343 aa overlap); and to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (389 aa) FASTA scores: opt: 165, E(): 0.0012, (25.2% identity in 345 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE28	complement(3983125..3984144)	Mycobacterium tuberculosis H37Rv	888091
NP_218062.1	CDS	cyp125	NC_000962.2	3984144	3985445	R	Rv3545c, (MT3649, MTCY03C7.11), len: 433 aa. Probable cyp125, cytochrome P-450 (EC 1.14.-.-), similar to others e.g. Q59723|LINC|CYP111 from Pseudomonas incognita (406 aa), FASTA scores: opt: 831, E(): 8e-45, (34.75% identity in 406 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor (411 aa), FASTA scores: opt: 694, E(): 3.3e-36, (32.35% identity in 417 aa overlap); Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FASTA scores: opt: 664, E(): 2.5e-34, (34.15% identity in 413 aa overlap); O08469|CPXY_BACSU|CYPA|CYP107J1 from Bacillus subtilis (410 aa), FASTA scores: opt: 579, E(): 5.6e-29, (30.05% identity in 366 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. Q50696|CYP124|Rv2266|MT2328|MTCY339.44c (428 aa) FASTA scores: opt: 1040, E(): 6.1e-58, (40.75% identity in 432 aa overlap). BELONGS TO THE CYTOCHROME P450 FAMILY.; cytochrome P450 125	complement(3984144..3985445)	Mycobacterium tuberculosis H37Rv	887782
NP_218063.1	CDS	fadA5	NC_000962.2	3985557	3986732	D	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase	3985557..3986732	Mycobacterium tuberculosis H37Rv	887360
NP_218064.1	CDS	Rv3547	NC_000962.2	3986844	3987299	D	Rv3547, (MTCY03C7.09c), len: 151 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. O85698|3SCF60.07 from Streptomyces lividans and Streptomyces coelicolor (149 aa), FASTA scores: opt: 353, E(): 6.3e-17, (42.55% identity in 134 aa overlap); Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa) FASTA scores: opt: 290, E(): 2.1e-12, (38.5% identity in 122 aa overlap) (similarity in N-terminus for this protein); BAB52932|Q988L5|MLL6688 from Rhizobium loti (Mesorhizobium loti) (148 aa), FASTA scores: opt: 105, E(): 3, (26.75% identity in 86 aa overlap). Also similar to mycobacterial hypothetical proteins e.g. Q9ZH81 from Mycobacterium paratuberculosis (144 aa), FASTA scores: opt: 366, E(): 8.2e-18, (43.9% identity in 123 aa overlap); and Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c from Mycobacterium tuberculosis (148 aa), FASTA scores: opt: 330, E(): 2.2e-15, (39.75% identity in 151 aa overlap); etc.; hypothetical protein	3986844..3987299	Mycobacterium tuberculosis H37Rv	887496
NP_218065.1	CDS	Rv3548c	NC_000962.2	3987382	3988296	R	Rv3548c, (MTCY03C7.08), len: 304 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases/reductases (generally belonging to the SDR FAMILY) e.g. Q9I4V1|PA1023 from Pseudomonas aeruginosa (305 aa), FASTA scores: opt: 446, E(): 1.7e-17, (43.75% identity in 256 aa overlap); Q9A6K0|CC2093 from Caulobacter crescentus (301 aa) FASTA scores: opt: 437, E(): 5.3e-17, (42.8% identity in 257 aa overlap); Q9HYH8|PA3427 from Pseudomonas aeruginosa (303 aa), FASTA scores: opt: 399, E(): 6.5e-15, (45.5% identity in 257 aa overlap); Q9VXJ0|CG3415 from Drosophila melanogaster (Fruit fly) (598 aa), FASTA scores: opt: 402, E(): 7.5e-15, (40.7% identity in 285 aa overlap); etc. Also highly similar to O53547|Rv3502c|MTV023.09c PUTATIVE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from (317 aa) FASTA scores: opt: 739, E(): 1.6e-33, (45.15% identity in 310 aa overlap); and other proteins from Mycobacterium tuberculosis. Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short chain dehydrogenase	complement(3987382..3988296)	Mycobacterium tuberculosis H37Rv	887452
NP_218066.1	CDS	Rv3549c	NC_000962.2	3988319	3989098	R	Rv3549c, (MTCY03C7.07), len: 259 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to various dehydrogenases/reductases (generally belong to the SDR FAMILY) e.g. Q9UKU3 from Homo sapiens (Human) (270 aa), FASTA scores: opt: 451, E(): 4.8e-21, (38.05% identity in 247 aa overlap); Q9S274|SCI28.09c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 439, E(): 2.4e-20, (36.8% identity in 231 aa overlap); Q9PFI6|XF0671 from Xylella fastidiosa (247 aa), FASTA scores: opt: 437, E(): 3.4e-20, (37.7% identity in 252 aa overlap); etc. Also highly similar to O33308|FABG5|Rv2766c|MTV002.31c ALCOHOL DEHYDROGENASE (SDR FAMILY) from Mycobacterium tuberculosis (260 aa), FASTA scores: opt: 504, E(): 2.3e-24, (38.5% identity in 244 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short chain dehydrogenase	complement(3988319..3989098)	Mycobacterium tuberculosis H37Rv	887849
NP_218067.1	CDS	echA20	NC_000962.2	3989153	3989896	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	3989153..3989896	Mycobacterium tuberculosis H37Rv	888232
NP_218068.1	CDS	Rv3551	NC_000962.2	3989896	3990774	D	Rv3551, (MTCY03C7.05c), len: 292 aa. Possible CoA-transferase, alpha subunit (EC 2.8.3.-), similar in part to other CoA-transferases e.g. Q59111|GCTA_ACIFE|GCTA GLUTACONATE COA-TRANSFERASE SUBUNIT A (EC 2.8.3.12) (GCT LARGE SUBUNIT) from Acidaminococcus fermentans (319 aa) FASTA scores: opt: 247, E(): 6.3e-09, (27.35% identity in 307 aa overlap); Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa), FASTA scores: opt: 222, E(): 2.3e-07, (27.55% identity in 243 aa overlap); BAB50895|MLL4183 from Rhizobium loti (Mesorhizobium loti) (285 aa), FASTA scores: opt: 206, E(): 2.8e-06, (27.4% identity in 281 aa overlap); etc. Also some similarity with O06167|SCOA_MYCTU|RVv504c|MT2579|MTCY07A7.10c PROBABLE SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE SUBUNIT A from Mycobacterium tuberculosis (248 aa), FASTA scores: opt: 210, E(): 1.4e-06, (25.5% identity in 247 aa overlap). BELONGS TO THE GLUTACONATE COA-TRANSFERASE SUBUNIT A FAMILY. Note that this putative protein may combine with the putative protein encoded by the downstream ORF Rv3552 to form a CoA-transferase that comprises two subunits.; CoA-transferase subunit alpha	3989896..3990774	Mycobacterium tuberculosis H37Rv	887235
NP_218069.1	CDS	Rv3552	NC_000962.2	3990771	3991523	D	Rv3552, (MTCY03C7.03c), len: 250 aa. Possible CoA-transferase, beta subunit (EC 2.8.3.-), similar in part to other CoA-transferases e.g. Q9I6R1|PA0227 from Pseudomonas aeruginosa (260 aa), FASTA scores: opt: 233, E(): 8.6e-08, (24.8% identity in 238 aa overlap); BAB50894|MLL4181 from Rhizobium loti (Mesorhizobium loti) (264 aa), FASTA scores: opt: 210, E(): 2.6e-06, (24.15% identity in 203 aa overlap); and AAK41345|Q97Z51|GCTB from Sulfolobus solfataricus (245 aa), FASTA scores: opt: 122, E(): 1.1, (25.5% identity in 243 aa overlap). POSSIBLY BELONGS TO THE GLUTACONATE COA-TRANSFERASE SUBUNIT B FAMILY. Note that this putative protein may combine with the putative protein encoded by the upstream ORF Rv3551 to form a CoA-transferase that comprises two subunits.; CoA-transferase subunit beta	3990771..3991523	Mycobacterium tuberculosis H37Rv	887453
NP_218070.1	CDS	Rv3553	NC_000962.2	3991621	3992688	D	Rv3553, (MTCY03C7.02c), len: 355 aa. Possible oxidoreductase (EC 1.-.-.-), highly similar (except in C-terminus) to Q9A327|CC3379 HYPOTHETICAL PROTEIN from Caulobacter crescentus (321 aa), FASTA scores: opt: 639, E(): 4.6e-29, (46.35% identity in 248 aa overlap); and Q9WZQ7|TM0800 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (314 aa), FASTA scores: opt: 622, E(): 4.1e-28, (37.95% identity in 340 aa overlap). Also similar to two TRANS-2-ENOYL-ACP REDUCTASES; Q99YD4|FABK|SPY1751 from Streptococcus pyogenes (323 aa), FASTA scores: opt: 604, E(): 4.4e-27, (33.25% identity in 346 aa overlap); and Q9FBC5|FABK from Streptococcus pneumoniae (324 aa), FASTA scores: opt: 553, E(): 3.3e-24, (32.1% identity in 346 aa overlap); and similar with several 2-NITROPROPANE DIOXYGENASES, e.g. Q9F7P8 from uncultured proteobacterium EBAC31A08 (322 aa), FASTA scores: opt: 505, E(): 1.7e-21, (33.6% identity in 348 aa overlap); Q9FMG0 (alias AAK44141) from Arabidopsis thaliana (Mouse-ear cress) (333 aa), FASTA scores: opt: 489, E(): 1.4e-20, (33.15% identity in 341 aa overlap); O28109|AF2173 (NCD2) from Archaeoglobus fulgidus (274 aa), FASTA scores: opt: 456, E(): 8.9e-19, (36.3% identity in 237 aa overlap); etc.; oxidoreductase	3991621..3992688	Mycobacterium tuberculosis H37Rv	887190
NP_218071.1	CDS	fdxB	NC_000962.2	3992685	3994742	D	Rv3554, (MTCY06G11.01, MTCY03C7.01c), len: 685 aa. Possible fdxB, two-domain protein, with ferredoxin reductase electron transfer component in C-terminal part (EC 1.-.-.-) and unknown function in N-terminal part. Indeed, N-terminal end is similar to O85832 HYPOTHETICAL 36.1 KDA PROTEIN from Sphingomonas aromaticivorans strain F199 (catabolic plasmid pNL1) (309 aa), FASTA scores: opt: 615, E(): 2.5e-30, (33.1% identity in 311 aa overlap); and P73428|SLL1468 HYPOTHETICAL 36.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (312 aa), FASTA scores: opt: 317, E(): 4.5e-12, (30.2% identity in 268 aa overlap). And C-terminal end is similar to Q9F9U6|PAAE protein involved in aerobic phenylacetate metabolism from Azoarcus evansii (360 aa), FASTA scores: opt: 935, E(): 7e-50, (43.85% identity in 351 aa overlap); CAC44653|PAAE|SCBAC17A6.08 PUTATIVE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE from Streptomyces coelicolor (368 aa), FASTA scores: opt: 93, E(): 9.5e-50, (41.95% identity in 372 aa overlap); Q9FA57|PACI FERREDOXIN from Azoarcus evansii (360 aa), FASTA scores: opt: 925, E(): 2.9e-49, (43.3% identity in 351 aa overlap); P76081|PAAE_ECOLI|B1392 PROBABLE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE from Escherichia coli strains K12 and W (356 aa), FASTA scores: opt: 910, E(): 2.4e-48, (43.05% identity in 353 aa overlap); Q9APJ6|PAAE ELECTRON TRANSFER PROTEIN (FRAGMENT) from Hyphomicrobium chloromethanicum (241 aa), FASTA scores: opt: 404, E(): 1.7e-17, (35.45% identity in 234 aa overlap); BAB51608|MLL5100 FERREDOXIN from Rhizobium loti (Mesorhizobium loti) (365 aa), FASTA scores: opt: 316, E(): 5.8e-12, (28.95% identity in 349 aa overlap); etc. C-terminus also similar to P96853|Rv3571|MTCY06G11.18 PUTATIVE ELECTRON TRANSFER PROTEIN from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 450, E(): 3.6e-20, (32.95% identity in 358 aa overlap). Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. BELONGS TO THE 2FE2S PLANT-TYPE FERREDOXIN FAMILY. COFACTOR: BINDS A 2FE-2S CLUSTER (BY SIMILARITY).; electron transfer protein FdxB	3992685..3994742	Mycobacterium tuberculosis H37Rv	887221
NP_218072.1	CDS	Rv3555c	NC_000962.2	3994830	3995699	R	Rv3555c, (MTCY06G11.02c), len: 289 aa. Hypothetical protein, highly similar to others from Mycobacterium tuberculosis e.g. O53562|AL022022|Rv3517|MTV023.24 (279 aa), FASTA scores: opt: 874, E(): 8.3e-48, (49.45% identity in 275 aa overlap); P71763|Rv1482c|MTCY277.03c (339 aa), FASTA scores: opt: 755, E(): 3e-40, (45.75% identity in 260 aa overlap); O69681|Rv3714c|MTV025.062c (296 aa), FASTA scores: opt: 733, E(): 6.4e-39, (44.1% identity in 281 aa overlap); etc. Also highly similar to other mycobacterial hypothetical proteins e.g. O07396|MAV346 from Mycobacterium avium (346 aa), FASTA scores: opt: 714, E(): 1.1e-37, (44.6% identity in 260 aa overlap); and Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa), FASTA scores: opt: 130, E(): 0.17, (35.1% identity in 57 aa overlap) (only partial homology with this protein). Shows some similarity to P52392|NHSR_STRAS PUTATIVE NOSIHEPTIDE RESISTANCE REGULATORY PROTEIN (ORF699) from Streptomyces actuosus (233 aa), FASTA scores: opt: 120, E(): 1.9, (25.25% identity in 194 aa overlap).; hypothetical protein	complement(3994830..3995699)	Mycobacterium tuberculosis H37Rv	887952
NP_218073.1	CDS	fadA6	NC_000962.2	3995804	3996964	R	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase	complement(3995804..3996964)	Mycobacterium tuberculosis H37Rv	887285
NP_218074.1	CDS	Rv3557c	NC_000962.2	3997029	3997631	R	Rv3557c, (MTCY06G11.04c), len: 200 aa. Probable transcriptional regulator, tetR family, similar to other e.g. Q9RRV9|DR2376 from Deinococcus radiodurans (197 aa) FASTA scores: opt: 326, E(): 2.3e-14, (31.2% identity in 189 aa overlap); Q9HZW2|PA2885 from Pseudomonas aeruginosa (198 aa), FASTA scores: opt: 308, E(): 3.5e-13, (31.55% identity in 187 aa overlap); Q9RFR4 from Pseudomonas fluorescens (207 aa), FASTA scores: opt: 291, E(): 4.7e-12, (29.75% identity in 195 aa overlap); Q9K8P5|BH2958 from Bacillus halodurans (215 aa), FASTA scores: opt: 271, E(): 9.9e-11, (23.95% identity in 192 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. O53641|Rv0158|MTV032.01 (214 aa), FASTA scores: opt: 232, E(): 3.5e-08, (25.5% identity in 192 aa overlap); and O06169|Rv2506|MTCY07A7.12 (215 aa), FASTA scores: opt: 215, E(): 4.5e-07, (35.15% identity in 148 aa overlap); etc. SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.; TetR family transcriptional regulator	complement(3997029..3997631)	Mycobacterium tuberculosis H37Rv	887467
YP_177988.1	CDS	PPE64	NC_000962.2	3997980	3999638	D	Rv3558, (MTCY06G11.05), len: 552 aa. Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 1908, E(): 1.7e-83, (58.5% identity in 583 aa overlap).; PPE family protein	3997980..3999638	Mycobacterium tuberculosis H37Rv	887822
NP_218076.1	CDS	Rv3559c	NC_000962.2	3999647	4000435	R	Rv3559c, (MTCY06G11.06c), len: 262 aa. Probable oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases e.g. Q9F5J1|SIM-NJ1|SIMD2 PUTATIVE 3-KETO-ACYL-REDUCTASE (SDR FAMILY) from Streptomyces antibioticus (273 aa), FASTA scores: opt: 510, E(): 2.8e-24, (40.15% identity in 249 aa overlap);Q9L2C9|SC7A8.29 PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (255 aa), FASTA scores: opt: 500, E(): 1.1e-23, (41.4% identity in 239 aa overlap); Q9HQ41|FABG|VNG1341G 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE from Halobacterium sp. strain NRC-1 (255 aa) FASTA scores: opt: 500, E(): 1.1e-23, (40.0% identity in 250 aa overlap); etc. Also similar to oxidoreductases from Mycobacterium tuberculosis eg Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 PUTATIVE OXIDOREDUCTASE (247 aa), FASTA scores: opt: 497, E(): 1.6e-23, (39.2% identity in 245 aa overlap).; short chain dehydrogenase	complement(3999647..4000435)	Mycobacterium tuberculosis H37Rv	887897
NP_218077.1	CDS	fadE30	NC_000962.2	4000432	4001589	R	Rv3560c, (MTCY06G11.07c), len: 385 aa. Probable fadE30, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 845, E(): 1.6e-47, (39.2% identity in 388 aa overlap); Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 734, E(): 2.8e-40, (35.5% identity in 386 aa overlap); Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa), FASTA scores: opt: 656, E(): 3.2e-35, (37.9% identity in 351 aa overlap); etc. Also similar to acyl-CoA dehydrogenases from Mycobacterium tuberculosis e.g. P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa), FASTA scores: opt: 939, E(): 1.4e-53, (43.8% identity in 404 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE30	complement(4000432..4001589)	Mycobacterium tuberculosis H37Rv	887838
NP_218078.1	CDS	fadD3	NC_000962.2	4001637	4003160	D	activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase	4001637..4003160	Mycobacterium tuberculosis H37Rv	887244
NP_218079.1	CDS	fadE31	NC_000962.2	4003161	4004294	D	Rv3562, (MTCY06G11.09), len: 377 aa. Probable fadE31, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa), FASTA scores: opt: 657, E(): 1.7e-34, (36.45% identity in 351 aa overlap); Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 653, E(): 3.2e-34, (33.95% identity in 392 aa overlap); Q9EX72|MLHC from Rhodococcus erythropolis (324 aa) FASTA scores: opt: 631, E(): 6.5e-33, (36.95% identity in 330 aa overlap); P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa), FASTA scores: opt: 347, E(): 1e-15, (28.6% identity in 385 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis e.g. P96842|FADE30|Rv3560c|MTCY06G11.07c (385 aa), FASTA scores: opt: 843, E(): 2.3e-46, (38.95% identity in 380 aa overlap). COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE31	4003161..4004294	Mycobacterium tuberculosis H37Rv	887884
NP_218080.1	CDS	fadE32	NC_000962.2	4004291	4005250	D	Rv3563, (MTCY06G11.10), len: 319 aa. Probable fadE32, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 347, E(): 7.6e-14, (35.15% identity in 333 aa overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FASTA scores: opt: 300, E(): 5.3e-11, (32.4% identity in 349 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 285, E(): 4.1e-10, (30.4% identity in 329 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 230, E(): 1.1e-07, (25.5% identity in 357 aa overlap); etc. Also similar to other from Mycobacterium tuberculosis eg P96846|FADE33|Rv3564|MTCY06G11.11 (318 aa), FASTA scores: opt: 478, E(): 7.6e-22, (32.9% identity in 292 aa overlap). COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE32	4004291..4005250	Mycobacterium tuberculosis H37Rv	887818
NP_218081.1	CDS	fadE33	NC_000962.2	4005247	4006203	D	Rv3564, (MTCY06G11.11), len: 318 aa. Probable fadE33, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to others e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 373, E(): 1.9e-15, (34.3% identity in 338 aa overlap); Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 277, E(): 1.4e-09, (31.95% identity in 335 aa overlap); Q9X7Y6|SC6A5.40c from Streptomyces coelicolor (395 aa), FASTA scores: opt: 273, E(): 2.5e-09, (30.1% identity in 352 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 478, E(): 7.9e-22, (32.9% identity in 292 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. P96845|FADE32|Rv3563|MTCY06G11.10 (319 aa), FASTA scores: opt: 478, E(): 7.9e-22, (32.9% identity in 292 aa overlap). COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE33	4005247..4006203	Mycobacterium tuberculosis H37Rv	888458
NP_218082.1	CDS	aspB	NC_000962.2	4006200	4007366	D	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase	4006200..4007366	Mycobacterium tuberculosis H37Rv	888305
YP_177989.1	CDS	nat	NC_000962.2	4007331	4008182	R	Rv3566c, (MT3671, MTCY06G11.13c), len: 283 aa. nat (alternate gene name: nhoA), arylamine N-acetyltransferase (EC 2.3.1.5) (see citations below), highly similar to O86309|NAT_MYCSM ARYLAMINE N-ACETYLTRANSFERASE from Mycobacterium smegmatis (see citation below) (275 aa), FASTA scores: opt: 1114, E(): 3e-66, (60.95% identity in 274 aa overlap). Also highly similar to others e.g. Q98D42|BAB51429|MLR4870 from Rhizobium loti (Mesorhizobium loti) (278 aa), FASTA scores: opt: 697, E(): 1.1e-38, (44.1% identity in 272 aa overlap); P77567|NHOA_ECOLI|B1463 from Escherichia coli strain K12 (281 aa), FASTA scores: opt: 537, E(): 4.4e-28, (38.85% identity in 273 aa overlap); Q00267|NHOA_SALTY from Salmonella typhimurium (281 aa), FASTA scores: opt: 507, E(): 4.3e-26, (34.8% identity in 273 aa overlap); etc. BELONGS TO THE ARYLAMINE N-ACETYLTRANSFERASE FAMILY. Note that previously known as nhoA (332 aa) and that nucleotide 4007874 has been changed since first submission (G deleted).; nhoA; arylamine n-acetyltransferase nat (arylamine acetylase)	complement(4007331..4008182)	Mycobacterium tuberculosis H37Rv	888005
YP_177990.1	CDS	Rv3566A	NC_000962.2	4008167	4008433	R	Rv3566A, len: 88 aa. Hypothetical unknown protein.; hypothetical protein	complement(4008167..4008433)	Mycobacterium tuberculosis H37Rv	3205089
NP_218084.1	CDS	Rv3567c	NC_000962.2	4008719	4009282	R	Rv3567c, (MTCY06G11.14c), len: 187 aa. Possible oxidoreductase (EC 1.-.-.-), similar to various oxidoreductases and hypothetical proteins e.g. O69360 ORF61 PROTEIN from Rhodococcus erythropolis (194 aa) FASTA scores: opt: 974, E(): 3e-59, (77.05% identity in 183 aa overlap); Q9JN75|MMYF PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (174 aa), FASTA scores: opt: 451, E(): 1e-23, (43.65% identity in 158 aa overlap); P54990|NTAB_CHEHE|NMOB NITRILOTRIACETATE MONOOXYGENASE COMPONENT B (EC 1.14.13.-) from Chelatobacter heintzii (322 aa), FASTA scores: opt: 409, E(): 1.3e-20, (38.3% identity in 167 aa overlap)Chelatobacter heintzii; AAK62356 PUTATIVE NADH:FMN OXIDOREDUCTASE from Burkholderia sp. DBT1 (177 aa), FASTA scores: opt: 360, E(): 1.6e-17, (36.15% identity in 155 aa overlap).; oxidoreductase	complement(4008719..4009282)	Mycobacterium tuberculosis H37Rv	887525
NP_218085.1	CDS	bphC	NC_000962.2	4009297	4010199	R	Rv3568c, (MTCY06G11.15c), len: 300 aa. Probable bphC, 2,3-dihydroxybiphenyl 1,2-dioxygenase (EC 1.13.11.39), highly similar to other e.g. Q9KWQ5|BPHC5 from Rhodococcus sp. RHA1 (300 aa), FASTA scores: opt: 1715, E(): 3.8e-103, (82.15% identity in 297 aa overlap); O50479|EDOB from Rhodococcus rhodochrous (300 aa) FASTA scores: opt: 1714, E(): 4.4e-103, (82.5% identity in 297 aa overlap); O69359|BPHC6 from Rhodococcus erythropolis (300 aa), FASTA scores: opt: 1647, E(): 9.1e-99, (78.25% identity in 299 aa overlap); Q9RBT2|BPHC1 from Pseudomonas sp. SY5 (301 aa) Pseudomonas sp. SY5 (298 aa) FASTA scores: opt: 767, E(): 3.9e-42, (42.8% identity in 299 aa overlap); P47228|BPHC_BURCE from Burkholderia cepacia (Pseudomonas cepacia) (297 aa), FASTA scores: opt: 670, E(): 6.8e-36, (40.55% identity in 296 aa overlap); etc. Contains PS00082 Extradiol ring-cleavage dioxygenases signature. BELONGS TO THE EXTRADIOL RING-CLEAVAGE DIOXYGENASE FAMILY.; biphenyl-2,3-diol 1,2-dioxygenase	complement(4009297..4010199)	Mycobacterium tuberculosis H37Rv	887886
NP_218086.1	CDS	bphD	NC_000962.2	4010196	4011071	R	Rv3569c, (MTCY06G11.16c), len: 291 aa. Probable bphD, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (EC 3.7.1.-), highly similar to others e.g. Q9KWQ6|BPHD2 from Rhodococcus sp. RHA1 (292 aa), FASTA scores: opt: 1468, E(): 1.3e-85, (75.5% identity in 294 aa overlap); Q52036 from Pseudomonas putida (286 aa), FASTA scores: opt: 785, E(): 1.9e-42, (45.1% identity in 295 aa overlap); Q52011|BPHD from Pseudomonas pseudoalcaligenes (286 aa), FASTA scores: opt: 774, E(): 9.3e-42, (44.05% identity in 295 aa overlap); P47229|BPHD_BURCE from Burkholderia cepacia (Pseudomonas cepacia) (286 aa) FASTA scores: opt: 772, E(): 1.2e-41, (44.5% identity in 295 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A. SIMILAR TO ALPHA/BETA HYDROLASE FOLD.; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD	complement(4010196..4011071)	Mycobacterium tuberculosis H37Rv	887378
NP_218087.1	CDS	Rv3570c	NC_000962.2	4011086	4012270	R	Rv3570c, (MTCY06G11.17c), len: 394 aa. Possible oxidoreductase (EC 1.-.-.-), most similar to hydroxylases and oxygenases (and also some similarity to acyl-coa dehydrogenases) e.g. O69349 HYDROXYLASE from Rhodococcus erythropolis (393 aa), FASTA scores: opt: 958, E(): 1.1e-53, (39.95% identity in 383 aa overlap); P26698|PIGM_RHOSO PIGMENT PROTEIN from Rhodococcus sp. strain ATCC 21145 (387 aa), FASTA scores: opt: 665, E(): 5.4e-35, (32.2% identity in 382 aa overlap); Q9ZGA9|LANZ5 OXYGENASE HOMOLOG from Streptomyces cyanogenus (397 aa) FASTA scores: opt: 588, E(): 4.5e-30, (30.55% identity in 386 aa overlap); Q9F0J3|NCNH HYDROXYLASE from Streptomyces arenae (405 aa), FASTA scores: opt: 580, E(): 1.5e-29, (31.25% identity in 336 aa overlap); O69789|BPFA INDOLE DIOXYGENASE from Rhodococcus opacus (399 aa), FASTA scores: opt: 558, E(): 3.7e-28, (31.8% identity in 387 aa overlap); etc.; oxidoreductase	complement(4011086..4012270)	Mycobacterium tuberculosis H37Rv	887241
NP_218088.1	CDS	hmp	NC_000962.2	4012417	4013493	D	Rv3571, (MTCY06G11.18), len: 358 aa. Possible hmp, oxidoreductase, hemoglobine-related protein (see citation below) (EC 1.-.-.-), similar to several e.g. Q44253|ATDA5 ANILINE DIOXYGENASE REDUCTASE COMPONENT from Acinetobacter sp (336 aa) FASTA scores: opt: 748, E(): 1.5e-38, (34.95% identity in 346 aa overlap); P95533|TDNB ELECTRON TRANSFER PROTEIN from Pseudomonas putida (337 aa), FASTA scores: opt: 723, E(): 5.2e-37, (36.35% identity in 341 aa overlap); AAK65059|SMA0752 POSSIBLE DIOXYGENASE REDUCTASE SUBUNIT from Rhizobium meliloti (Sinorhizobium meliloti) (353 aa) FASTA scores: opt: 495, E(): 4.9e-23, (31.9% identity in 345 aa overlap); P76081|PAAE_ECOLI|B1392 PROBABLE PHENYLACETIC ACID DEGRADATION NADH OXIDOREDUCTASE (356 aa), FASTA scores: opt: 364, E(): 5.1e-15, (34.45% identity in 357 aa overlap); Q9L131|HMPA FLAVOHEMOPROTEIN from Streptomyces coelicolor (398 aa), FASTA scores: opt: 352, E(): 3e-14, (32.8% identity in 247 aa overlap); etc. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. Note that it has been shown hmp transcription increased at early stationary phase and is lower at late stationary phase and during exponential growth.; hemoglobine-like protein	4012417..4013493	Mycobacterium tuberculosis H37Rv	887315
NP_218089.1	CDS	Rv3572	NC_000962.2	4013511	4014041	D	Rv3572, (MTCY06G11.19), len: 176 aa. Hypothetical unknown protein.; hypothetical protein	4013511..4014041	Mycobacterium tuberculosis H37Rv	887227
NP_218090.1	CDS	fadE34	NC_000962.2	4014077	4016212	R	Rv3573c, (MTCY06G11.20c), len: 711 aa. Probable fadE34, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to others, especially in C-terminal half, e.g. Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa) FASTA scores: opt: 780, E(): 2.8e-39, (44.1% identity in 347 aa overlap); Q9A6N8|CC2049 from Caulobacter crescentus (401 aa), FASTA scores: opt: 705, E(): 8.7e-35, (41.5% identity in 342 aa overlap); Q9EX72|MLHC from Rhodococcus erythropolis (324 aa), FASTA scores: opt: 673, E(): 6.1e-33, (42.05% identity in 283 aa overlap); P41367|ACDM_PIG|ACADM from Sus scrofa (Pig)(421 aa) FASTA scores: opt: 325, E(): 4.9e- 13, (28.5% identity in 368 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. P95097|FADE22|Rv3061c|MTCY22D7.20 (721 aa), FASTA scores: opt: 1635, E(): 2.7e-90, (42.65% identity in 729 aa overlap). COULD BELONG TO THE ACYL-COA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE34	complement(4014077..4016212)	Mycobacterium tuberculosis H37Rv	887843
NP_218091.1	CDS	Rv3574	NC_000962.2	4016484	4017083	D	Rv3574, (MTCY06G11.21), len: 199 aa. Probable transcriptional regulator tetR family, similar to others e.g. Q9KXK1|SCC53.10 from Streptomyces coelicolor (250 aa) FASTA scores: opt: 492, E(): 4.8e-25, (44.8% identity in 183 aa overlap); Q9RA03|KSTR from Rhodococcus erythropolis (208 aa), FASTA scores: opt: 294, E(): 3.1e-12, (28.9% identity in 187 aa overlap); BAB54261|MLR7895 from Rhizobium loti (Mesorhizobium loti) (193 aa), FASTA scores: opt: 166, E(): 0.00062, (32.05% identity in 78 aa overlap); P17446|BETI_ECOLI|B0313 from Escherichia coli strain K12 (195 aa), FASTA scores: opt: 142, E(): 0.0034, (25. 6% identity in 168 aa overlap); etc. Equivalent to AAK48038 from Mycobacterium tuberculosis strain CDC1551 (243 aa) but shorter 44 aa. Contains possible helix-turn-helix motif from aa 37-58 (+3.70 SD). POSSIBLY BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.; transcriptional regulatory protein TetR-family	4016484..4017083	Mycobacterium tuberculosis H37Rv	887204
NP_218092.1	CDS	Rv3575c	NC_000962.2	4017089	4018168	R	Rv3575c, (MTCY06G11.22c), len: 359 aa. Probable transcriptional regulator belonging to lacI family, similar to others e.g. BAB53947|MLL8376 from Rhizobium loti (Mesorhizobium loti) (358 aa), FASTA scores: opt: 707, E(): 2.6e-35, (35.5% identity in 355 aa overlap); Q9RRI9|DR2501 from Deinococcus radiodurans (359 aa) FASTA scores: opt: 544, E(): 1.6e-25, (40.35% identity in 347 aa overlap); Q9RL31|SCF51A.34 from Streptomyces coelicolor (347 aa), FASTA scores: opt: 307, E(): 2.9e-11, (30.0% identity in 330 aa overlap); O87590|CELR_THEFU from Thermomonospora fusca (340 aa), FASTA scores: opt: 280, E(): 1.2e-09, (32.3% identity in 353 aa overlap); P21867|RAFR_ECOLI from Escherichia coli (335 aa) FASTA scores: opt: 241, E(): 2.6e-07, (27.15% identity in 269 aa overlap); etc. Equivalent to AAK48039 from Mycobacterium tuberculosis strain CDC1551 (404 aa) but shorter 45 aa. Contains possible helix-turn-helix motif, at aa 9-30 (+5.86 SD). COULD BELONG TO THE LACI FAMILY OF TRANSCRIPTIONAL REGULATORS.; transcriptional regulatory protein LacI-family	complement(4017089..4018168)	Mycobacterium tuberculosis H37Rv	888084
YP_177991.1	CDS	lppH	NC_000962.2	4018358	4019071	D	Rv3576, (MTCY06G11.23), len: 237 aa. Possible lppH, conserved lipoprotein, similar in part with proteins from Mycobacterium tuberculosis; C-terminus of Q11053|PKNH_MYCTU|PKNH|Rv1266c|MT1304|MTCY50.16 PROBABLE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.-) (626 aa) FASTA scores: opt: 396, E(): 6.5e-19, (36.0% identity in 200 aa overlap); and with P71740|LPPR|Rv2403c|MTCY253.17 PROBABLE LIPOPROTEIN PROTEIN (251 aa), FASTA scores: opt: 134, E(): 0.087, (22.7% identity in 207 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as pknM.; pknM; lipoprotein LppH	4018358..4019071	Mycobacterium tuberculosis H37Rv	888444
NP_218094.1	CDS	Rv3577	NC_000962.2	4019262	4020128	D	Rv3577, (MTCY06G11.24), len: 288 aa (other start sites possible upstream; equivalent to AAK48041 from Mycobacterium tuberculosis strain CDC1551 (379 aa) but shorter 91 aa). Hypothetical protein, showing some similarity to Q9RI88|SCJ11.16c HYPOTHETICAL 37.9 KDA PROTEIN from Streptomyces coelicolor (349 aa) FASTA scores: opt: 285, E(): 1.5e-10, (27.45% identity in 266 aa overlap).; hypothetical protein	4019262..4020128	Mycobacterium tuberculosis H37Rv	888442
NP_218095.1	CDS	arsB2	NC_000962.2	4020142	4021383	D	Rv3578, (MTCY06G11.25), len: 413 aa. Possible arsB2, arsenical pump integral membrane protein, similar to many e.g. Q9I1J6|ARSB|PA2278 from Pseudomonas aeruginosa (427 aa), FASTA scores: opt: 375, E(): 3.1e-15, (32.15% identity in 429 aa overlap); Q9K8K7|ARSB|BH2999 from Bacillus halodurans (436 aa), FASTA scores: opt: 360, E(): 2.5e-14, (28.7% identity in 432 aa overlap); P52146|ARB2_ECOLI from Escherichia coli (plasmid R46) (429 aa), FASTA scores: opt: 345, E(): 2e-13, (29.8% identity in 426 aa overlap); etc. Also highly similar to Q9KYM0|SC9H11.21c PROBABLE MEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 730, E(): 1.7e-36, (53.95% identity in 443 aa overlap). SEEMS TO BELONG TO THE ARS FAMILY.; arsenical PUMP integral membrane protein ArsB2	4020142..4021383	Mycobacterium tuberculosis H37Rv	888329
NP_218096.1	CDS	Rv3579c	NC_000962.2	4021425	4022393	R	Rv3579c, (MTCY06G11.26c), len: 322 aa. Possible tRNA/rRNA methyltransferase (EC 2.1.1.-), equivalent, but longer 31 aa, to Q9CCW4|ML0324 PUTATIVE METHYLTRANSFERASE from Mycobacterium leprae (278 aa), FASTA scores: opt: 1517, E(): 3.4e-79, (83.75% identity in 277 aa overlap). Also highly similar to Q9L0Q5|SCD8A.09 from Streptomyces coelicolor (314 aa), FASTA scores: opt: 937, E(): 3.4e-46, (56.75% identity in 319 aa overlap); and similar to others e.g. Q06753|YACO_BACSU from Bacillus subtilis (249 aa), FASTA scores: opt: 616, E(): 4.9e-28, (41.05% identity in 246 aa overlap); Q9KGF2|BH0113 from Bacillus halodurans (249 aa), FASTA scores: opt: 596, E(): 6.7e-27, (38.5% identity in 244 aa overlap); P74328|Y955_SYNY3|SLR0955 from Synechocystis sp. strain PCC 6803 (384 aa), FASTA scores: opt: 585, E(): 4e-26, (35.85% identity in 304 aa overlap); P39290|YJFH_ECOLI|B4180 from Escherichia coli strain K12 (243 aa), FASTA scores: opt: 521, E(): 1.2e-22, (38.1% identity in 244 aa overlap); etc. Equivalent to AAK48043 from Mycobacterium tuberculosis strain CDC1551 (253 aa) but longer 69 aa. POSSIBLY BELONGS TO THE RNA METHYLTRANSFERASE TRMH FAMILY.; tRNA/rRNA methyltransferase	complement(4021425..4022393)	Mycobacterium tuberculosis H37Rv	888317
YP_177992.1	CDS	cysS	NC_000962.2	4022394	4023803	R	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase	complement(4022394..4023803)	Mycobacterium tuberculosis H37Rv	888628
NP_218098.1	CDS	ispF	NC_000962.2	4023868	4024347	R	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	complement(4023868..4024347)	Mycobacterium tuberculosis H37Rv	888221
NP_218099.1	CDS	ispD	NC_000962.2	4024344	4025039	R	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	complement(4024344..4025039)	Mycobacterium tuberculosis H37Rv	887787
NP_218100.1	CDS	Rv3583c	NC_000962.2	4025056	4025544	R	Rv3583c, (MTV024.01c, MTCY06G11.30c), len: 162 aa. Possible transcriptional factor, identical to Q9CCW7|ML0320 PUTATIVE TRANSCRIPTION FACTOR from Mycobacterium leprae (165 aa), FASTA scores: opt: 1004, E(): 6.1e-56, (97.55% identity in 162 aa overlap); and Q9ZBM8|MLCB1450.01c PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (94 aa), FASTA scores: opt: 600, E(): 6e-31, (97.85% identity in 94 aa overlap). Also highly similar to others e.g. Q9L0Q9|SCD8A.05 from Streptomyces coelicolor (160 aa), FASTA scores: opt: 878, E(): 4.3e-48, (85.0% identity in 160 aa overlap); Q9K600|BH3935 from Bacillus halodurans (153 aa) FASTA scores: opt: 383, E(): 3.1e-17, (36.4% identity in 151 aa overlap); Q9KD36|BH1383 from Bacillus halodurans (164 aa) FASTA scores: opt: 305, E(): 2.4e-12, (33.55% identity in 164 aa overlap); etc.; transcription factor	complement(4025056..4025544)	Mycobacterium tuberculosis H37Rv	887854
NP_218101.1	CDS	lpqE	NC_000962.2	4025830	4026378	D	Rv3584, (MTV024.02), len: 182 aa. Possible lpqE, conserved lipoprotein, equivalent to Q9ZBM7|MLCB1450.02|LPQE|ML0319 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (183 aa), FASTA scores: opt: 722, E(): 6.2e-37, (63.45% identity in 175 aa overlap). Also similar in part to Q9KK69 EXPORTED PROTEIN 996A010 (FRAGMENT) from Mycobacterium avium (41 aa), FASTA scores: opt: 180, E(): 0.00012, (69.25% identity in 39 aa overlap); and Q9L0R0|SCD8A.04c PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (241 aa), FASTA scores: opt: 127, E(): 0.86, (27.15% identity in 173 aa overlap). Equivalent to AAK48048 from Mycobacterium tuberculosis strain CDC1551 (238 aa) but shorter 56 aa. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. TBparse score is 0.895.; lipoprotein LpqE	4025830..4026378	Mycobacterium tuberculosis H37Rv	887254
NP_218102.1	CDS	radA	NC_000962.2	4026444	4027886	D	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA	4026444..4027886	Mycobacterium tuberculosis H37Rv	887287
NP_218103.1	CDS	Rv3586	NC_000962.2	4027891	4028967	D	non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair; DNA integrity scanning protein DisA	4027891..4028967	Mycobacterium tuberculosis H37Rv	887485
NP_218104.1	CDS	Rv3587c	NC_000962.2	4028968	4029762	R	Rv3587c, (MTV024.05c), len: 264 aa. Probable conserved membrane protein, equivalent to Q9CBJ2|ML1918 HYPOTHETICAL MEMBRANE PROTEIN from Mycobacterium leprae (263 aa), FASTA scores: opt: 1438, E(): 2.4e-57, (77.55% identity in 267 aa overlap). Contains hydrophobic stretch in N-terminus; possible signal sequence. TBparse score is 0.903.; hypothetical protein	complement(4028968..4029762)	Mycobacterium tuberculosis H37Rv	888057
NP_218105.1	CDS	Rv3588c	NC_000962.2	4029871	4030494	R	Rv3588c, (MTV024.06c), len: 207 aa. Probable carbonic anhydrase (EC 4.2.1.1), equivalent to Q9CBJ1|ML1919 PUTATIVE CARBONIC ANHYDRASE from Mycobacterium leprae (213 aa), FASTA scores: opt: 1160, E(): 3.1e-66, (84.55% identity in 207 aa overlap). Also similar to many e.g. Q9X903|SCH35.03 from Streptomyces coelicolor (207 aa), FASTA scores: opt: 689, E(): 1.6e-36, (53.85% identity in 195 aa overlap); Q9RS89|DR2238 from Deinococcus radiodurans (264 aa), FASTA scores: opt: 451, E(): 2e-21, (39.7% identity in 189 aa overlap); Q39589|BETA-CA1 from Chlamydomonas reinhardtii (267 aa) FASTA scores: opt: 419, E(): 2.1e-19, (36.55% identity in 197 aa overlap); etc. Contains PS00704 and PS00705 Prokaryotic-type carbonic anhydrases signature 1 and 2. BELONGS TO THE PLANT AND PROKARYOTIC CARBONIC ANHYDRASE FAMILY. TBparse score is 0.899.; carbonic anhydrase	complement(4029871..4030494)	Mycobacterium tuberculosis H37Rv	887836
NP_218106.1	CDS	mutY	NC_000962.2	4030493	4031407	D	Rv3589, (MTV024.07), len: 304 aa. Probable mutY, adenine glycosylase (EC 3.2.2.-) (see citation below), equivalent to Q9CBJ0|MUTY|ML1920 PROBABLE DNA GLYCOSYLASE from Mycobacterium leprae (297 aa), FASTA scores: opt: 1592, E(): 2.6e-94, (74.9% identity in 303 aa overlap). Also similar to many DNA glycosylases (generally adenine glycosylases) e.g. Q9S6T7|SCE94.06 from Streptomyces coelicolor (308 aa), FASTA scores: opt: 965, E(): 2.6e-54, (50.5% identity in 297 aa overlap); Q9S6G1|MUTY from Streptomyces antibioticus (307 aa), FASTA scores: opt: 901, E(): 3.1e-50, (48.5% identity in 303 aa overlap); Q9HPQ6|MUTY|VNG1520G from Halobacterium sp. strain NRC-1 (312 aa), FASTA scores: opt: 566, E(): 7.2e-29, (39.85% identity in 296 aa overlap); BAB53965|MLL7523 from Rhizobium loti (Mesorhizobium loti) (396 aa), FASTA scores: opt: 511, E(): 2.8e-25, (39.65% identity in 237 aa overlap); Q05869|MUTY_SALTY|MUTB from Salmonella typhimurium (350 aa), FASTA scores: opt: 421, E(): 3.8e-20, (35.2% identity in 227 aa overlap); etc. COULD BELONG TO THE NTH/MUTY FAMILY. TBparse score is 0.905.; adenine glycosylase MutY	4030493..4031407	Mycobacterium tuberculosis H37Rv	886639
YP_177993.1	CDS	PE_PGRS58	NC_000962.2	4031404	4033158	R	Rv3590c, (MTV024.08c, MTCY6F7.04), len: 584 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to e.g. O53439|Rv1091|MTV017.44 (853 aa), FASTA scores: opt: 2005, E(): 1.4e-70, (54.95% identity in 646 aa overlap).; PE-PGRS family protein	complement(4031404..4033158)	Mycobacterium tuberculosis H37Rv	887874
NP_218108.1	CDS	Rv3591c	NC_000962.2	4033269	4034042	R	Rv3591c, (MTCY6F7.03), len: 257 aa. Possible hydrolase (EC 3.-.-.-), equivalent to Q9CBI9|ML1921 HYPOTHETICAL PROTEIN from Mycobacterium leprae (256 aa) FASTA scores: opt: 1421, E(): 5.6e-83, (78.5% identity in 251 aa overlap). Also similar to others e.g. Q9K3V0|SCD10.27 PUTATIVE HYDROLASE from Streptomyces coelicolor (352 aa), FASTA scores: opt: 193, E(): 5.2e-05, (33.35% identity in 270 aa overlap); O33745|STTC THIOESTERASE (EC 3.1.2.-) from Streptomyces sp (308 aa) FASTA scores: opt: 242, E(): 3.6e-08, (30.35% identity in 270 aa overlap); Q9RK95|SCF1.09 PUTATIVE HYDROLASE from Streptomyces coelicolor (258 aa), FASTA scores: opt: 239, E(): 4.9e-08, (30.75% identity in 247 aa overlap); Q9HZ14|PA3226 PROBABLE HYDROLASE from Pseudomonas aeruginosa (275 aa), FASTA scores: opt: 226, E(): 3.4e-07, (26.6% identity in 252 aa overlap); Q9HPT9|EST|VNG1474G CARBOXYLESTERASE from Halobacterium sp. strain NRC-1 (274 aa), FASTA scores: opt: 215, E(): 1.7e-06, (26.95% identity in 256 aa overlap); etc.; hydrolase	complement(4033269..4034042)	Mycobacterium tuberculosis H37Rv	886316
NP_218109.1	CDS	TB11.2	NC_000962.2	4034057	4034374	D	Rv3592, (MTCY6F7.02c), len: 105 aa. TB11.2, conserved hypothetical protein (see citations from 2000 below), equivalent to Q9CBI8|ML1922 HYPOTHETICAL PROTEIN from Mycobacterium leprae (105 aa) FASTA scores: opt: 591, E(): 2.5e-34, (84.6% identity in 104 aa overlap). Shows some similarity with other bacterial hypothetical proteins e.g. Q9RXN8|DR0272 from Deinococcus radiodurans (109 aa), FASTA scores: opt: 178, E(): 1e-05, (34.3% identity in 102 aa overlap); P38049|YHGC_BACSU from Bacillus subtilis (166 aa) FASTA scores: opt: 175, E(): 2.4e-05, (40.85% identity in 71 aa overlap); Q9K649|BH3883 from Bacillus halodurans (102 aa) FASTA scores: opt: 162, E(): 0.00012, (33.75% identity in 80 aa overlap); etc.; hypothetical protein	4034057..4034374	Mycobacterium tuberculosis H37Rv	886278
NP_218110.1	CDS	lpqF	NC_000962.2	4034352	4035710	D	Rv3593, (MTCY6F7.01c), len: 452 aa. Probable lpqF, conserved lipoprotein, equivalent to Q9CBI7|MPQF|ML1923 PROBALE SECRETED PROTEIN from Mycobacterium leprae (454 aa), FASTA scores: opt: 2465, E(): 5.7e-144, (79.15% identity in 451 aa overlap). Also similar to Q9KJ91 HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces clavuligerus (430 aa), FASTA scores: opt: 609, E(): 5.2e-30, (30.3% identity in 350 aa overlap); and some similarity with putative beta-lactamases e.g. Q9RYR7|DRA0241 BETA LACTAMASE-RELATED PROTEIN from Deinococcus radiodurans (499 aa), FASTA scores: opt: 322, E(): 2.5e-12, (28.25% identity in 322 aa overlap). Equivalent to AAK48057 from Mycobacterium tuberculosis strain CDC1551 (438 aa) but longer 14 aa. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein LpqF	4034352..4035710	Mycobacterium tuberculosis H37Rv	886290
NP_218111.1	CDS	Rv3594	NC_000962.2	4035857	4036684	D	Rv3594, (MTCY07H7B.28c), len: 275 aa. Hypothetical protein, highly similar in part with Q9ZX49|GP29 from Mycobacteriophage TM4 (547 aa), FASTA scores: opt: 526, E(): 1.3e-25, (46.25% identity in 186 aa overlap); and Q9FZS0|LYSA|GP2 from Mycobacterium phage Ms6 (384 aa) FASTA scores: opt: 147, E(): 0.064, (33.35% identity in 84 aa overlap).; hypothetical protein	4035857..4036684	Mycobacterium tuberculosis H37Rv	885659
YP_177994.1	CDS	PE_PGRS59	NC_000962.2	4036731	4038050	R	Rv3595c, (MTCY07H7B.27), len: 439 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to many e.g. O53439|Rv1091|MTV017.44 (853 aa), FASTA scores: opt: 1644, E(): 1.2e-57, (58.75% identity in 492 aa overlap).; PE-PGRS family protein	complement(4036731..4038050)	Mycobacterium tuberculosis H37Rv	885464
YP_177995.1	CDS	clpC1	NC_000962.2	4038158	4040704	R	Rv3596c, (MTCY07H7B.26), len: 848 aa. Probable clpC1, ATP-dependent protease ATP-binding subunit (EC 3.4.-.-), equivalent to P24428|CLPC_MYCLE PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT from Mycobacterium leprae (848 aa) (see Misra et al., 1996), FASTA scores: opt: 5286, E(): 0, (97.15% identity in 845 aa overlap). Also highly similar to members of the clpA/clpB family e.g. Q9S6T8|SCE94.24c from Streptomyces coelicolor (841 aa) FASTA scores: opt: 4399, E(): 0, (81.0% identity in 848 aa overlap); Q9KGG2|CLPC|BH0103 from Bacillus halodurans (813 aa), FASTA scores: opt: 3279, E(): 3.8e-173, (61.9% identity in 808 aa overlap); Q55662|CLPC|SLL0020 from Synechocystis sp. strain PCC 6803 (821 aa), FASTA scores: opt: 3201, E(): 7.6e-169, (60.5% identity in 820 aa overlap); P51332|CLPC_PORPU from Porphyra purpurea (821 aa), FASTA scores: opt: 3045, E(): 3e-160, (57.65% identity in 817 aa overlap); P37571|CLPC_BACSU|MECB from Bacillus subtilis (810 aa), FASTA scores: opt: 2969, E(): 4.6e-156, (61.15% identity in 811 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Note that previously known as clpC. BELONGS TO THE CLPA/CLPB FAMILY, CLPC SUBFAMILY.; clpC; ATP-dependent protease ATP-binding subunit ClpC1	complement(4038158..4040704)	Mycobacterium tuberculosis H37Rv	885104
NP_218114.1	CDS	lsr2	NC_000962.2	4040981	4041319	R	Rv3597c, (MTCY07H7B.25), len: 112 aa. Probable lsr2, identical to P24094|LSR2_MYCLE|ML0234 LSR2 PROTEIN PRECURSOR (15 KDA ANTIGEN) (A15) from Mycobacterium leprae (112 aa), FASTA scores: opt: 698, E(): 6.7e-37, (92.85% identity in 112 aa overlap). Also highly similar to others e.g. Q9X8N1|SCE94.26c from Streptomyces coelicolor (111 aa), FASTA scores: opt: 379, E(): 4.4e-17, (58.05% identity in 112 aa overlap); Q9ETI2|LSR2 from Corynebacterium equii (Rhodococcus equi) (119 aa), FASTA scores: opt: 328, E(): 6.9e-14, (47.5% identity in 120 aa overlap); and Q9RKK8|SCD25.12c from Streptomyces coelicolor (105 aa), FASTA scores: opt: 293, E(): 9.4e-12, (47.75% identity in 111 aa overlap).; iron-regulated LSR2 protein precursor	complement(4040981..4041319)	Mycobacterium tuberculosis H37Rv	885580
NP_218115.1	CDS	lysS	NC_000962.2	4041423	4042940	R	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase	complement(4041423..4042940)	Mycobacterium tuberculosis H37Rv	885574
NP_218116.1	CDS	Rv3599c	NC_000962.2	4042952	4043035	R	Rv3599c, (MTCY07H7B.23), len: 27 aa. Hypothetical unknown protein.; hypothetical protein	complement(4042952..4043035)	Mycobacterium tuberculosis H37Rv	887149
NP_218117.1	CDS	Rv3600c	NC_000962.2	4043041	4043859	R	type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase	complement(4043041..4043859)	Mycobacterium tuberculosis H37Rv	885572
NP_218118.1	CDS	panD	NC_000962.2	4043862	4044281	R	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase	complement(4043862..4044281)	Mycobacterium tuberculosis H37Rv	885596
NP_218119.1	CDS	panC	NC_000962.2	4044281	4045210	R	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase	complement(4044281..4045210)	Mycobacterium tuberculosis H37Rv	885459
NP_218120.1	CDS	Rv3603c	NC_000962.2	4045207	4046118	R	Rv3603c, (MTCY07H7B.19), len: 303 aa. Conserved hypothetical ala-, leu-rich protein, identical except at N-terminus (really different) to AAK48066|MT3708 CHALCONE/STILBENE SYNTHASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (361 aa) FASTA scores: opt: 1742, E(): 8.3e-95, (100.0% identity in 275 aa overlap). Equivalent to O69525|MLCB2548.02c|ML0229 HYPOTHETICAL 32.7 KDA PROTEIN from Mycobacterium leprae (309 aa), FASTA scores: opt: 947, E(): 2.4e-48, (67.85% identity in 311 aa overlap). Also highly similar to Q9X845|SCE126.02c HYPOTHETICAL 42.2 KDA PROTEIN from Streptomyces coelicolor (420 aa), FASTA scores: opt: 683, E(): 8.5e-33, (49.3% identity in 284 aa overlap).; hypothetical protein	complement(4045207..4046118)	Mycobacterium tuberculosis H37Rv	885583
NP_218121.2	CDS	Rv3604c	NC_000962.2	4046303	4047496	R	Rv3604c, (MTCY07H7B.18), len: 397 aa. Probable conserved ala-, arg-, pro-rich transmembrane protein, equivalent to O69526|MLCB2548.03c|ML0228 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (432 aa), FASTA scores: opt: 869, E(): 2.9e-31, (59.7% identity in 432 aa overlap). Contains two possible membrane-spanning domains. N-terminus shortened since first submission (previously 462 aa).; transmembrane protein	complement(4046303..4047496)	Mycobacterium tuberculosis H37Rv	885232
NP_218122.1	CDS	Rv3605c	NC_000962.2	4047705	4048181	R	Rv3605c, (MTCY07H7B.17), len: 158 aa. Probable conserved secreted or membrane protein, identical to O69527|MLCB2548.04c|ML0227 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (158 aa), FASTA scores: opt: 944, E(): 2.6e-56, (85.45% identity in 158 aa overlap). Also similar to other proteins e.g. Q9X8I2|SCE9.09 POSSIBLE SECRETED PROTEIN from Streptomyces coelicolor (162 aa), FASTA scores: opt: 174, E(): 9.2e-05, (31.25% identity in 128 aa overlap); etc. Contains possible N-terminal signal sequence.; hypothetical protein	complement(4047705..4048181)	Mycobacterium tuberculosis H37Rv	885844
NP_218123.1	CDS	folK	NC_000962.2	4048181	4048747	R	Rv3606c, (MTCY07H7B.16), len: 188 aa. Probable folK, 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase (EC 2.7.6.3), equivalent to O69528|HPPK_MYCLE|FOLK|ML0226\MLCB2548.05c 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE from Mycobacterium leprae (191 aa) FASTA scores: opt: 772, E(): 1.2e-44, (63.15% identity in 190 aa overlap). Also similar to many e.g. P71512|HPPK_METEX|FOLK|FOLA from Methylobacterium extorquens (158 aa), FASTA scores: opt: 292, E(): 1.4e-12, (36.85% identity in 171 aa overlap); O33726|HPPK_STRPY|FOLK|SPY1100 from Streptococcus pyogenes (166 aa), FASTA scores: opt: 234, E(): 1.1e-08, (34.3% identity in 175 aa overlap); Q9X8I1|SCE9.08 from Streptomyces coelicolor (203 aa), FASTA scores: opt: 232, E(): 1.7e-08, (43.25% identity in 185 aa overlap); P26281|HPPK_ECOLI|FOLK|B0142 from Escherichia coli strain K12 (158 aa), FASTA scores: opt: 198, E(): 2.6e-06, (32.85% identity in 143 aa overlap); etc. BELONGS TO THE HPPK FAMILY.; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase FolK	complement(4048181..4048747)	Mycobacterium tuberculosis H37Rv	885848
YP_177996.1	CDS	folB	NC_000962.2	4048744	4049145	R	Rv3607c, (MTCY07H7B.15), len: 133 aa. Probable folB, dihydroneopterin aldolase (EC 4.1.2.25), equivalent to O69529|FOLB_MYCLE|ML0225|MLCB2548.06c PROBABLE DIHYDRONEOPTERIN ALDOLASE from Mycobacterium leprae (132 aa), FASTA scores: opt: 673, E(): 5.1e-37, (74.8% identity in 131 aa overlap). Also similar to many e.g. Q9X8I0|FOLB_STRCO|SCE9.07 from Streptomyces coelicolor (119 aa), FASTA scores: opt: 334, E(): 4.5e-15, (46.15% identity in 117 aa overlap); P74342|FOLB_SYNY3|SLR1626 from Synechocystis sp. strain PCC 6803 (118 aa) FASTA scores: opt: 287, E(): 5e-12, (38.45% identity in 117 aa overlap); P28823|FOLB_BACSU|FOLA from Bacillus subtilis (120 aa), FASTA scores: opt: 283, E(): 9.2e-12, (39.0% identity in 118 aa overlap); etc. BELONGS TO THE DHNA FAMILY. Note that previously known as folX.; folX; dihydroneopterin aldolase FolB	complement(4048744..4049145)	Mycobacterium tuberculosis H37Rv	885345
YP_177997.1	CDS	folP1	NC_000962.2	4049138	4049980	R	Rv3608c, (MTCY07H7B.14), len: 280 aa. Probable folP1, dihydropteroate synthase 1 (EC 2.5.1.15), equivalent to O69530|FOLP (alias Q9S0T0|FOLP and Q9R2U9|FOLP) DIHYDRONEOPTERIN ALDOLASE from Mycobacterium leprae (284 aa), FASTA scores: opt: 1418, E(): 7.2e-77, (76.75% identity in 284 aa overlap). Also highly similar to many e.g. Q9X8H8|SCE9.05 from Streptomyces coelicolor (288 aa), FASTA scores: opt: 953, E(): 2.4e-49, (56.0% identity in 266 aa overlap); Q9A3I0|CC3224 from Caulobacter crescentus (274 aa), FASTA scores: opt: 682, E(): 2.6e-33, (45.5% identity in 268 aa overlap); P73248|DHPS_SYNY3|FOLP|SLR2026 from Synechocystis sp. strain PCC 6803 (289 aa), FASTA scores: opt: 665, E(): 2.7e-32, (44.55% identity in 265 aa overlap); P26282|DHPS_ECOLI|FOLP|B3177 from Escherichia coli strain K12 (282 aa), FASTA scores: opt: 642, E(): 6.1e-31, (41.95% identity in 274 aa overlap); etc. Contains PS00792 Dihydropteroate synthase signature 1, PS00793 Dihydropteroate synthase signature 2. SIMILAR TO OTHER SPECIES DHPS.; dihydropteroate synthase	complement(4049138..4049980)	Mycobacterium tuberculosis H37Rv	885831
NP_218126.1	CDS	folE	NC_000962.2	4049977	4050585	R	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I	complement(4049977..4050585)	Mycobacterium tuberculosis H37Rv	885346
NP_218127.1	CDS	ftsH	NC_000962.2	4050601	4052883	R	Rv3610c, (MT3714, MTCY07H7B.12), len: 760 aa. ftsH, membrane-bound protease (cell division protein) (EC 3.4.24.-) (see citations below), equivalent to Q9CD58|FTSH_MYCLE|ML0222 (alias O69532|FTSH) CELL DIVISION PROTEIN FTSH HOMOLOG from Mycobacterium leprae (787 aa), FASTA scores: opt: 4388, E(): 9.6e-205, (87.2% identity in 790 aa overlap). Also highly similar to many FTSH proteins e.g. O52395|FTSH from Mycobacterium smegmatis (769 aa), FASTA scores: opt: 3976, E(): 7.6e-185, (82.4% identity in 761 aa overlap); Q9X8I4|SCE9.11c from Streptomyces coelicolor (668 aa), FASTA scores: opt: 2417, E(): 1.4e-109, (57.2% identity in 668 aa overlap); P72991|FTH4_SYNY3|SLR1604 from Synechocystis sp. strain PCC 6803 (616 aa), FASTA scores: opt: 1926, E(): 7.2e-86, (49.35% identity in 612 aa overlap); P28691|FTSH_ECOLI|HFLB|MRSC|TOLZ|B3178 from Escherichia coli strain K12 (644 aa), FASTA scores: opt: 1859, E(): 1.3e-82, (48.95% identity in 605 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00674 AAA-protein family signature. BELONGS TO THE AAA FAMILY OF ATPASES AND PEPTIDASE FAMILY M41 (ZINC METALLOPROTEASE). COFACTOR: BINDS ONE ZINC ION (POTENTIAL).; membrane-bound protease FTSH (cell division protein)	complement(4050601..4052883)	Mycobacterium tuberculosis H37Rv	885732
NP_218128.1	CDS	Rv3611	NC_000962.2	4052950	4053603	D	Rv3611, (MTCY07H7B.11c), len: 217 aa. Hypothetical unknown arg-, pro-rich protein. Possible ORF containing several direct repeats.; hypothetical protein	4052950..4053603	Mycobacterium tuberculosis H37Rv	885469
NP_218129.1	CDS	Rv3612c	NC_000962.2	4053518	4053847	R	Rv3612c, (MTCY07H7B.10), len: 109 aa. Conserved hypothetical protein. Residues 58 to 81 highly similar to N-terminal part of AAK46718|MT2424 HYPOTHETICAL 3.9 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (36 aa), FASTA scores: opt: 108, E(): 0.38, (69.25% identity in 26 aa overlap).; hypothetical protein	complement(4053518..4053847)	Mycobacterium tuberculosis H37Rv	885381
NP_218130.1	CDS	Rv3613c	NC_000962.2	4053881	4054042	R	Rv3613c, (MTCY07H7B.09), len: 53 aa. Hypothetical unknown protein.; hypothetical protein	complement(4053881..4054042)	Mycobacterium tuberculosis H37Rv	885124
NP_218131.1	CDS	Rv3614c	NC_000962.2	4054142	4054696	R	Rv3614c, (MTCY07H7B.08), len: 184 aa. Conserved hypothetical protein, equivalent to Q49730|ML0407|B1620_C3_264|MLCL383.03 HYPOTHETICAL 24.2 KDA PROTEIN from Mycobacterium leprae (216 aa) FASTA scores: opt: 899, E(): 1.7e-51, (71.3% identity in 188 aa overlap); and similar to two hypothetical proteins from Mycobacterium leprae: Q9CDD6|ML0056 (169 aa), FASTA scores: opt: 285, E(): 1.2e-11, (38.35% identity in 172 aa overlap); and O33090|MLCB628.19c (338 aa), FASTA scores: opt: 289, E(): 1.2e-11, (38.95% identity in 172 aa overlap). Also highly similar to O69732|Rv3867|MTV027.02 HYPOTHETICAL 19.9 KDA PROTEIN from Mycobacterium tuberculosis (183 aa), FASTA scores: opt: 563, E(): 1e-29, (54.9% identity in 173 aa overlap).; hypothetical protein	complement(4054142..4054696)	Mycobacterium tuberculosis H37Rv	885777
NP_218132.1	CDS	Rv3615c	NC_000962.2	4054812	4055123	R	Rv3615c, (MTCY07H7B.07), len: 103 aa. Conserved hypothetical protein, equivalent to Q49723|ML0406|B1620_C2_214|MLCL383 HYPOTHETICAL 11.1 KDA PROTEIN from Mycobacterium leprae (106 aa), FASTA scores: opt: 364, E(): 4.1e-18, (60.85% identity in 92 aa overlap). Also shows similarity to P96212|Rv3865|MTCY01A6.03 HYPOTHETICAL 10.6 KDA PROTEIN from Mycobacterium tuberculosis (103 aa), FASTA scores: opt: 198, E(): 6.8e-07, (36.25% identity in 102 aa overlap).; hypothetical protein	complement(4054812..4055123)	Mycobacterium tuberculosis H37Rv	885770
NP_218133.1	CDS	Rv3616c	NC_000962.2	4055197	4056375	R	Rv3616c, (MTCY07H7B.06), len: 392 aa. Conserved hypothetical ala-, gly-rich protein, equivalent to Q49722|ML0405|B1620_C2_213|MLCL383.01 HYPOTHETICAL 40.8 KDA PROTEIN from Mycobacterium leprae (394 aa) FASTA scores: opt: 1620, E(): 5.3e-75, (62.7% identity in 394 aa overlap). Also similar to P96213|Rv3864|MTCY01A6.04c HYPOTHETICAL 42.1 KDA PROTEIN from Mycobacterium tuberculosis (402 aa), FASTA scores: opt: 389, E(): 1.1e-12, (31.75% identity in 400 aa overlap).; hypothetical protein	complement(4055197..4056375)	Mycobacterium tuberculosis H37Rv	885377
NP_218134.1	CDS	ephA	NC_000962.2	4057733	4058701	D	Rv3617, (MTCY07H7B.05c, MTCY15C10.35c), len: 322 aa. Probable ephA, epoxide hydrolase (EC 3.3.2.3) (see citation below), similar to many e.g. Q9A8W9|CC1229 from Caulobacter crescentus (330 aa), FASTA scores: opt: 965, E(): 1.8e-51, (46.15% identity in 323 aa overlap); Q9M9W5|F18C1.13 from Arabidopsis thaliana (Mouse-ear cress) (331 aa), FASTA scores: opt: 778, E(): 4.3e-40, (40.35% identity in 332 aa overlap); Q9S7P1 from Oryza sativa (Rice) (322 aa), FASTA scores: opt: 774, E(): 7.4e-40, (41.1% identity in 321 aa overlap); P80299|HYES_RAT|EPHX2 from Rattus norvegicus (Rat) (554 aa), FASTA scores: opt: 759, E(): 9.5e-39, (40.5% identity in 306 aa overlap) (similarity only with the C-terminal part for this one); etc. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. Contains PS00888 Cyclic nucleotide-binding domain signature 1.; epoxide hydrolase EphA	4057733..4058701	Mycobacterium tuberculosis H37Rv	885769
NP_218135.1	CDS	Rv3618	NC_000962.2	4058698	4059885	D	Rv3618, (MTCY15C10.34c, MTCY07H7B.04c), len: 395 aa. Possible monooxygenase (EC 1.-.-.-), similar to others (principally bacterial luciferases alpha chain) e.g. Q9JN87|MMYO PUTATIVE ALKANAL MONOOXYGENASE from Streptomyces coelicolor (373 aa), FASTA scores: opt: 949, E(): 8.9e-54, (41.7% identity in 374 aa overlap); Q9EUT9|LIMB LIMONENE MONOOXYGENASE from Rhodococcus erythropolis (387 aa), FASTA scores: opt: 856, E(): 9.1e-48, (42.0% identity in 388 aa overlap); AAK72698 LUXA-LIKE PROTEIN from Bradyrhizobium japonicum (458 aa) FASTA scores: opt: 350, E(): 4.4e-15, (29.7% identity in 347 aa overlap); Q9K4C1|2SC6G5.34c PUTATIVE ALKANAL MONOOXYGENASE (LUCIFERASE) from Streptomyces coelicolor (342 aa), FASTA scores: opt: 291, E(): 2.2e-11, (26.5% identity in 362 aa overlap); etc. Also similar to P95278|Rv1936|MTCY09F9.28c HYPOTHETICAL 41.8 KDA PROTEIN from Mycobacterium tuberculosis (369 aa), FASTA scores: opt: 473, E(): 4.3e-23, (32.55% identity in 378 aa overlap).; monooxygenase	4058698..4059885	Mycobacterium tuberculosis H37Rv	885276
NP_218136.1	CDS	esxV	NC_000962.2	4059984	4060268	R	Rv3619c, (MTCY15C10.33, MTCY07H7B.03, MT3721), len: 94 aa. esxV, ESAT-6 like protein (see citations below), highly similar to many Mycobacterial ESAT-6 like proteins e.g. O53942|ES65_MYCTU PUTATIVE ESAT-6 LIKE PROTEIN 5 from Mycobacterium tuberculosis (94 aa), FASTA scores: opt: 582, E(): 4.4e-33, (92.55% identity in 94 aa overlap); Q49946|ES6X_MYCLE|U1756D PUTATIVE ESAT-6 LIKE PROTEIN X from Mycobacterium leprae (95 aa), FASTA scores: opt: 409, E(): 2.5e-21, (64.15% identity in 92 aa overlap); etc. Strictly identical to P96364|ES61_MYCTU|Rv1037c|MT1066|MTCY10G2.12 PUTATIVE ESAT-6 LIKE PROTEIN 1 (94 aa). BELONGS TO THE ESAT6 FAMILY.; ES6_1, Mtb9.9D; putative ESAT-6 like protein ESXV (ESAT-6 like protein 1)	complement(4059984..4060268)	Mycobacterium tuberculosis H37Rv	885328
NP_218137.1	CDS	esxW	NC_000962.2	4060295	4060591	R	Rv3620c, (MTCY15C10.32, MTCY07H7B.02, MT3722), len: 98 aa. esxW, ESAT-6 like protein (see citation below). Member of the M. tuberculosis hypothetical QILSS protein family with Rv1038c, Rv1792, Rv2347c and Rv1197|O05299|ES63_MYCTU|MT1235|MTCI364.09 PUTATIVE ESAT-6 LIKE PROTEIN 3 from Mycobacterium tuberculosis (98 aa), FASTA scores: opt: 638, E(): 2.3e-36, (97.95% identity in 98 aa overlap). Also similar to Q49945|ES6Y_MYCLE PUTATIVE ESAT-6 LIKE PROTEIN Y from Mycobacterium leprae (100 aa), FASTA scores: opt: 370, E(): 2.1e-18, (57.9% identity in 95 aa overlap); etc. BELONGS TO THE ESAT6 FAMILY.; ES6_10, QILSS; putative ESAT-6 like protein ESXW (ESAT-6 like protein 10)	complement(4060295..4060591)	Mycobacterium tuberculosis H37Rv	885787
YP_177998.1	CDS	PPE65	NC_000962.2	4060648	4061889	R	Rv3621c, (MTCY15C10.31, MTCY07H7B.01), len: 413 aa. Member of the Mycobacterium tuberculosis PPE family, ala-, gly-rich proteins, similar to many e.g. Q10813|YS92_MYCTU|Rv2892c|MT2959|MTCY274.23c (408 aa) FASTA scores: opt: 955, E(): 1.8e-42, (44.45% identity in 423 aa overlap).; PPE family protein	complement(4060648..4061889)	Mycobacterium tuberculosis H37Rv	885097
YP_177999.1	CDS	PE32	NC_000962.2	4061899	4062198	R	Rv3622c, (MTCY15C10.30), len: 99 aa. Member of the Mycobacterium tuberculosis PE family (see citation below), but no glycine rich C-terminus present. Similar to others e.g. O53938|Rv1788|MTV049.10 (99 aa), FASTA scores: opt: 376, E(): 7.1e-17, (65.6% identity in 96 aa overlap).; PE family protein	complement(4061899..4062198)	Mycobacterium tuberculosis H37Rv	885712
NP_218140.1	CDS	lpqG	NC_000962.2	4062527	4063249	D	Rv3623, (MTCY15C10.29c), len: 240 aa. Probable lpqG, conserved lipoprotein, showing some similarity with hypothetical proteins e.g. Q57432 from Methanosarcina barkeri (251 aa), FASTA scores: opt: 319, E(): 6.8e-12, (31.2% identity in 218 aa overlap); Q9PEA5|XF1123 OUTER MEMBRANE PROTEIN from Xylella fastidiosa (242 aa) FASTA scores: opt: 312, E(): 1.7e-11, (28.25% identity in 237 aa overlap); BAB49547|MLR2408 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (236 aa), FASTA scores: opt: 304, E(): 5e-11, (27.05% identity in 244 aa overlap); etc. Has suitable signal peptide and prokaryotic membrane lipoprotein lipid attachment site (PS00013).; lipoprotein LpqG	4062527..4063249	Mycobacterium tuberculosis H37Rv	885233
NP_218141.1	CDS	hpt	NC_000962.2	4063254	4063904	R	Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase	complement(4063254..4063904)	Mycobacterium tuberculosis H37Rv	885398
NP_218142.1	CDS	mesJ	NC_000962.2	4063901	4064872	R	Rv3625c, (MT3727, MTCY15C10.27), len: 323 aa. Possible mesJ, cell cycle protein, equivalent to O69538|Y0C5_MYCLE|ML0213|MLCB2548.18c HYPOTHETICAL 34.1 KDA PROTEIN from Mycobacterium leprae (323 aa) FASTA scores: opt: 1592, E(): 9e-92, (78.0% identity in 327 aa overlap). Similar to bacterial hypothetical proteins Q9X8I6|SCE9.13c from Streptomyces coelicolor (352 aa) FASTA scores: opt: 705, E(): 1.4e-36, (47.85% identity in 305 aa overlap); and Q9HXZ3|PA3638 from Pseudomonas aeruginosa (442 aa), FASTA scores: opt: 382, E(): 2e-16, (40.6% identity in 271 aa overlap). But also similar (or with similarity) to bacterial cell cycle proteins (MESJ) e.g. Q9KPX0|VC2242 MESJ PROTEIN from Vibrio cholerae (440 aa), FASTA scores: opt: 363, E(): 3e-15, (34.8% identity in 253 aa overlap); Q9RV23|DR1207 (600 aa) CELL CYCLE PROTEIN MESJ (PUTATIVE/CYTOSINE DEAMINASE-RELATED PROTEIN) from Deinococcus radiodurans (600 aa), FASTA scores: opt: 310, E(): 7.6e-12, (36.6% identity in 265 aa overlap) (similar only at the N-terminal end); Q9PFJ8|XF0659 CELL CYCLE PROTEIN from Xylella fastidiosa (437 aa), FASTA scores: opt: 301, E(): 2.1e-11, (35.05% identity in 271 aa overlap); P52097|MESJ_ECOLI|B0188 PUTATIVE CELL CYCLE PROTEIN MESJ from Escherichia coli strain K12(432 aa) FASTA scores: opt: 299, E(): 2.8e-11, (34.65% identity in 277 aa overlap); etc. BELONGS TO THE UPF0072 (MESJ/YCF62) FAMILY.; cell cycle protein MESJ	complement(4063901..4064872)	Mycobacterium tuberculosis H37Rv	885409
NP_218143.1	CDS	Rv3626c	NC_000962.2	4064851	4065903	R	Rv3626c, (MTCY15C10.26), len: 350 aa. Conserved hypothetical protein, similar to Q9X8I7|SCE9.14c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (375 aa) FASTA scores: opt: 720, E(): 2.2e-38, (41.55% identity in 361 aa overlap); and shows some similarity to Q9HPS0|VNG1497C HYPOTHETICAL PROTEIN (317 aa) FASTA scores: opt: 226, E(): 4.5e-07, (29.7% identity in 347 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142).; hypothetical protein	complement(4064851..4065903)	Mycobacterium tuberculosis H37Rv	885792
NP_218144.1	CDS	Rv3627c	NC_000962.2	4065900	4067285	R	Rv3627c, (MTCY15C10.25), len: 461 aa. Hypothetical ala-rich protein which may have cleavable signal peptide at N-terminal end. Equivalent to O69539|MLCB2548.20c|ML0211 HYPOTHETICAL 47.2 KDA PROTEIN from Mycobacterium leprae (461 aa), FASTA scores: opt: 2295, E(): 3.5e-116, (76.2% identity in 462 aa overlap); and C-terminal end shows similarity with O05758|MLCB5.28c HYPOTHETICAL 24.1 KDA PROTEIN from Mycobacterium leprae (225 aa), FASTA scores: opt: 268, E(): 1.8e-07, (32.25% identity in 220 aa overlap). Also similar (or with similarity) to various proteins (notably penicillin binding proteins) e.g. Q9X8I8|SCE9.15c HYPOTHETICAL 45.9 KDA PROTEIN from Streptomyces coelicolor (459 aa) FASTA scores: opt: 707, E(): 8.3e-31, (35.75% identity in 439 aa overlap); Q9Z541|SC9B2.18c PUTATIVE CARBOXYPEPTIDASE from Streptomyces coelicolor (451 aa), FASTA scores: opt: 450, E(): 5.3e-17, (31.75% identity in 469 aa overlap); Q9JVV4|NMA0665 PUTATIVE PEPTIDASE from Neisseria meningitidis (serogroup A) (or Q9JY10|NMB1797 from serogroup B) (469 aa), FASTA scores: opt: 269, E(): 3e-07, (26.15% identity in 463 aa overlap); O85665|PBP3 PENICILLIN BINDING PROTEIN 3 from Neisseria gonorrhoeae (469 aa), FASTA scores: opt: 265, E(): 4.9e-07, (31.85% identity in 201 aa overlap); P45161|PBP4_HAEIN|DACB|HI1330 PENICILLIN-BINDING PROTEIN 4 PRECURSOR/PEPTIDASE (479 aa) FASTA scores: opt: 230, E(): 3.8e-05, (27.9% identity in 394 aa overlap); P24228|PBP4_ECOLI|DACB|B3182 PENICILLIN-BINDING PROTEIN 4 PRECURSOR from Escherichia coli strain K12 (477 aa), FASTA scores: opt: 166, E(): 0.1, (28.2% identity in 408 aa overlap); etc.; hypothetical protein	complement(4065900..4067285)	Mycobacterium tuberculosis H37Rv	885728
NP_218145.1	CDS	ppa	NC_000962.2	4067423	4067911	D	catalyzes the hydrolysis of pyrophosphate; inorganic pyrophosphatase	4067423..4067911	Mycobacterium tuberculosis H37Rv	885775
NP_218146.1	CDS	Rv3629c	NC_000962.2	4067957	4069054	R	Rv3629c, (MTCY15C10.23), len: 365 aa. Probable conserved integral membrane protein, equivalent to O69543|MLCB2548.26|ML0205 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (356 aa), FASTA scores: opt: 1547, E(): 3e-89, (66.2% identity in 361 aa overlap). Also similar to other membrane and hypothetical proteins e.g. CAC37534|SCIF3.15c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (363 aa), FASTA scores: opt: 819, E(): 7.7e-44, (51.55% identity in 351 aa overlap); Q9CGK3|YKJK HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (339 aa) FASTA scores: opt: 683, E(): 2.2e-35, (48.3% identity in 350 aa overlap); Q9KY24|SCC8A.24c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (380 aa) FASTA scores: opt: 528, E(): 1.1e-25, (50.25% identity in 372 aa overlap); Q9RJH8|SCF73.09 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (370 aa) FASTA scores: opt: 439, E(): 3.9e-20, (50.2% identity in 384 aa overlap); Q9PE36|XF1192 INTEGRAL MEMBRANE PROTEIN from Xylella fastidiosa (341 aa), FASTA scores: opt: 337, E(): 8.3e-14, (47.65% identity in 361 aa overlap); etc.; hypothetical protein	complement(4067957..4069054)	Mycobacterium tuberculosis H37Rv	885351
NP_218147.1	CDS	Rv3630	NC_000962.2	4069175	4070470	D	Rv3630, (MTCY15C10.22c), len: 431 aa. Probable conserved integral membrane, highly similar to P71789|YF10_MYCTU|Rv1510|MTCY277.32 HYPOTHETICAL 44.3 KDA PROTEIN from Mycobacterium tuberculosis (432 aa) FASTA scores: opt: 1940, E(): 2.3e-103, (70.75% identity in 424 aa overlap). Note that N-terminal end is highly similar to AAK45825|MT1558 HYPOTHETICAL 18.1 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (172 aa) FASTA scores: opt: 649, E(): 4.2e-30, (61.65% identity in 167 aa overlap); and C-terminal end is highly similar to AAK45826|MT1560 HYPOTHETICAL 25.8 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (256 aa), FASTA scores: opt: 1269, E(): 2.6e-65, (76.7% identity in 253 aa overlap). Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site, so could be a protease.; integral membrane protein	4069175..4070470	Mycobacterium tuberculosis H37Rv	885802
NP_218148.1	CDS	Rv3631	NC_000962.2	4070514	4071239	D	Rv3631, (MTCY15C10.21c), len: 241 aa. Possible transferase (EC 2.-.-.-), more specifically a glycosyltransferase (EC 2.4.-.-), equivalent to O69542|MLCB2548.24c|ML0207 PUTATIVE TRANSFERASE (PUTATIVE GLYCOSYLTRANSFERASE) from Mycobacterium leprae (239 aa) FASTA scores: opt: 1303, E(): 2.8e-72, (81.2% identity in 239 aa overlap). Also similar to many dolichyl-phosphate mannose synthases and hypothetical proteins e.g. O59263|PH1585 HYPOTHETICAL 34.6 KDA PROTEIN from Pyrococcus horikoshii (313 aa), FASTA scores: opt: 472, E(): 1.2e-21, (36.65% identity in 232 aa overlap); Q9V152|PAB1971 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE from Pyrococcus abyssi (287 aa), FASTA scores: opt: 467, E(): 2.3e-21, (35.85% identity in 223 aa overlap); Q58619|YC22_METJA|MJ1222 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (243 aa), FASTA scores: opt: 400, E(): 2.4e-17, (33.35% identity in 228 aa overlap); O26474|MTH374 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE RELATED PROTEIN from Methanobacterium thermoautotrophicum (291 aa) FASTA scores: opt: 354, E(): 1.7e-14, (33.5% identity in 218 aa overlap); O26239|MTH136 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE from Methanobacterium thermoautotrophicum (220 aa), FASTA scores: opt: 345, E(): 4.8e-14, (33.5% identity in 221 aa overlap); etc.; transferase	4070514..4071239	Mycobacterium tuberculosis H37Rv	885314
NP_218149.1	CDS	Rv3632	NC_000962.2	4071236	4071580	D	Rv3632, (MTCY15C10.20c), len: 114 aa. Possible conserved membrane protein, equivalent to O69541|MLCB2548.23c|ML0208 HYPOTHETICAL 12.9 KDA PROTEIN (PUTATIVE MEMBRANE PROTEIN) from Mycobacterium leprae (113 aa), FASTA scores: opt: 594, E(): 7.1e-35, (82.0% identity in 111 aa overlap).; hypothetical protein	4071236..4071580	Mycobacterium tuberculosis H37Rv	885711
NP_218150.1	CDS	Rv3633	NC_000962.2	4071791	4072666	D	Rv3633, (MTCY15C10.19c), len: 291 aa. Conserved hypothetical protein, similar to Q9X5S6|MMCH from Streptomyces lavendulae (254 aa), FASTA scores: opt: 368, E(): 3.2e-16, (35.05% identity in 194 aa overlap); Q9APW1 HYPOTHETICAL 32.7 KDA PROTEIN from Pseudomonas aeruginosa (295 aa), FASTA scores: opt: 359, E(): 1.3e-15, (37.65% identity in 170 aa overlap); Q9APV4 HYPOTHETICAL 34.1 KDA PROTEIN from Pseudomonas aeruginosa (309 aa), FASTA scores: opt: 316, E(): 7.6e-13, (28.65% identity in 262 aa overlap). And some similarity to Q9HGD7|FUM9 FUM9P from Gibberella moniliformis (300 aa), FASTA scores: opt: 254, E(): 6.5e-09, (29.95% identity in 157 aa overlap); and P47181|YJ9S_YEAST|YJR154W|J2240 HYPOTHETICAL 39.0 KDA PROTEIN from Saccharomyces cerevisiae (Baker's yeast) (346 aa), FASTA scores: opt: 190, E(): 8.5e-05, (26.75% identity in 127 aa overlap). Also similar to P71782|YF01_MYCTU|Rv1501|MT1550|MTCY277.23 from Mycobacterium tuberculosis (273 aa), FASTA scores: opt: 286, E(): 5.5e-11, (27.5% identity in 280 aa overlap).; hypothetical protein	4071791..4072666	Mycobacterium tuberculosis H37Rv	885252
NP_215015.2	CDS	galE1	NC_000962.2	4072667	4073611	R	Rv3634c, (MTCY15C10.18), len: 314 aa. galE1, UDP-glucose 4-epimerase (EC 5.1.3.2) (see citations below), equivalent to O69544|ML0204|RMLB2|MLCB2548.27c PUTATIVE SUGAR DEHYDRATASE (PUTATIVE SUGAR-NUCLEOTIDE DEHYDRATASE) from Mycobacterium leprae (319 aa), FASTA scores: opt: 1798, E(): 8.2e-100, (86.4% identity in 309 aa overlap). Also similar to other UDP-GLUCOSE 4-EPIMERASES e.g. Q9WYX9|TM0509 from Thermotoga maritima (309 aa) FASTA scores: opt: 877, E(): 4.8e-45, (45.8% identity in 308 aa overlap); Q57664|GALE_METJA|MJ0211 from Methanococcus jannaschii (305 aa), FASTA scores: opt: 792, E(): 5.4e-40, (42.05% identity in 309 aa overlap); Q9K6S7|BH3649 from Bacillus halodurans (311 aa), FASTA scores: opt: 723, E(): 7e-36, (40.5% identity in 316 aa overlap); Q9HSV1|GALE2|VNG0063G from Halobacterium sp. strain NRC-1 (328 aa), FASTA scores: opt: 597, E(): 2.3e-28, (36.35% identity in 322 aa overlap); etc. Contains short-chain alcohol dehydrogenase family signature (PS00061) but this maynot be significant. BELONGS TO THE SUGAR EPIMERASE FAMILY. Note that previously known as rmlB2, a DTDP-glucose 4,6-dehydratase (EC 4.2.1.46) (see Ma et al., 2001).; rmlB2; UDP-glucose 4-epimerase GALE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)	complement(4072667..4073611)	Mycobacterium tuberculosis H37Rv	885765
NP_218152.1	CDS	Rv3635	NC_000962.2	4073634	4075409	D	Rv3635, (MTCY15C10.17c), len: 591 aa (start unclear). Probable conserved transmembrane protein, equivalent, but longer 25 aa, to O69545|ML0203|MLCB2548.28 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (569 aa), FASTA scores: opt: 2933, E(): 4.6e-173, (77.0% identity in 569 aa overlap).; transmembrane protein	4073634..4075409	Mycobacterium tuberculosis H37Rv	885675
NP_218153.1	CDS	Rv3636	NC_000962.2	4075752	4076099	D	Rv3636, (MTCY15C10.16c), len: 115 aa. Possible transposase, weakly similar to others e.g. O69924|SC3C8.12 PUTATIVE TRANSPOSASE from Streptomyces coelicolor (487 aa) FASTA scores: opt: 132, E(): 0.12, (33.05% identity in 112 aa overlap); O96916 TC1-LIKE TRANSPOSASE from Anopheles gambiae (African malaria mosquito) (332 aa), FASTA scores: opt: 117, E(): 0.84, (30.75% identity in 91 aa overlap); Q9R2U5|IS466A|IS466A-ORF|TNPA|IS469|SCP1.276 TRANSPOSASE (INSERTION ELEMENT IS466S TRANSPOSASE) from Streptomyces coelicolor (513 aa), FASTA scores: opt: 114, E(): 2, (30.5% identity in 82 aa overlap); etc. Similar in part to P96288|Rv2943|MTCY24G1.06c HYPOTHETICAL 45.8 KDA PROTEIN from Mycobacterium tuberculosis (413 aa), FASTA scores: opt: 533, E(): 1.4e-28, (74.55% identity in 110 aa overlap). Contains possible helix-turn-helix motif from aa 19-40 (+4.98 SD).; transposase	4075752..4076099	Mycobacterium tuberculosis H37Rv	885274
NP_218154.1	CDS	Rv3637	NC_000962.2	4076484	4076984	D	Rv3637, (MTCY15C10.15c), len: 166 aa. Possible transposase. C-terminal end highly similar to Q9RLQ9|ISTA PUTATIVE TRANSPOSASE A (FRAGMENT) from Mycobacterium bovis (102 aa), FASTA scores: opt: 397, E(): 1.4e-19, (58.8% identity in 102 aa overlap). Weakly similar to others e.g. Q9KJ02 PUTATIVE TRANSPOSASE (FRAGMENT) from Polyangium cellulosum (329 aa), FASTA scores: opt: 191, E(): 1.6e-05, (32.1% identity in 134 aa overlap); Q9LCU2|ISTA COINTEGRASE from Pseudomonas aeruginosa (382 aa) FASTA scores: opt: 144, E(): 0.024, (26.8% identity in 123 aa overlap); P15025|ISTA_PSEAE TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS21 from Pseudomonas aeruginosa (390 aa), FASTA scores: opt: 144, E(): 0.025, (26.85% identity in 123 aa overlap); etc. Also highly similar to C-terminal end of P96288|Rv2943|MTCY24G1.06c HYPOTHETICAL 45.8 KDA PROTEIN from Mycobacterium tuberculosis (413 aa) FASTA scores: opt: 722, E(): 1.5e-40, (63.7% identity in 168 aa overlap).; transposase	4076484..4076984	Mycobacterium tuberculosis H37Rv	885496
NP_218155.1	CDS	Rv3638	NC_000962.2	4076984	4077730	D	Rv3638, (MTCY15C10.14c), len: 248 aa. Possible transposase, highly similar to Q9RLQ8|ISTB ISTB PROTEIN from Mycobacterium bovis (266 aa), FASTA scores: opt: 784, E(): 4e-46, (78.0% identity in 259 aa overlap); and similar to others e.g. P15026|ISTB_PSEAE INSERTION SEQUENCE IS21 PUTATIVE ATP-BINDING PROTEIN from Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 420, E(): 2.2e-21, (38.8% identity in 255 aa overlap); Q45619|ISTB_BACST INSERTION SEQUENCE IS5376 PUTATIVE ATP-BINDING PROTEIN from Bacillus stearothermophilus (251 aa), FASTA scores: opt: 402, E(): 3.6e-20, (34.5% identity in 232 aa overlap); P15026|ISTB_ECOLI ISTB PROTEIN from Escherichia coli (265 aa), FASTA scores: opt: 419, E(): 8e-23, (38.8% identity in 255 aa overlap); etc. C-terminus highly similar to C-terminus of P96287|Rv2944|MTCY24G1.05 HYPOTHETICAL 25.5 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (alias AAK47343|MT3016 IS1533, ORFB from Mycobacterium tuberculosis strain CDC1551) (238 aa), FASTA scores: opt: 784, E(): 3.6e-46, (87.4% identity in 135 aa overlap).; transposase	4076984..4077730	Mycobacterium tuberculosis H37Rv	885803
NP_218156.1	CDS	Rv3639c	NC_000962.2	4077884	4078450	R	Rv3639c, (MTCY15C10.13), len: 188 aa. Hypothetical protein, with C-terminus highly similar to N-terminus of P95044|Rv0698|MTCY210.15 HYPOTHETICAL 22.3 KDA PROTEIN from Mycobacterium tuberculosis (203 aa), FASTA scores: opt: 224, E(): 4.5e-07, (54.8% identity in 73 aa overlap).; hypothetical protein	complement(4077884..4078450)	Mycobacterium tuberculosis H37Rv	885244
NP_218157.1	CDS	Rv3640c	NC_000962.2	4078520	4079749	R	Rv3640c, (MTCY15C10.12), len: 409 aa. Probable transposase, highly similar to others e.g. Q48882 TRANSPOSASE from Mycobacterium avium (411 aa) FASTA scores: opt: 1574, E(): 6.2e-93, (59.75% identity in 400 aa overlap); Q9AKV5 PUTATIVE TRANSPOSASE (FRAGMENT) from Mycobacterium paratuberculosis (395 aa), FASTA scores: opt: 1566, E(): 1.9e-92, (60.0% identity in 395 aa overlap); Q48368 TRANSPOSASE from Mycobacterium avium (410 aa), FASTA scores: opt: 1561, E(): 4.1e-92, (59.4% identity in 404 aa overlap); etc.; transposase	complement(4078520..4079749)	Mycobacterium tuberculosis H37Rv	885324
NP_218158.1	CDS	fic	NC_000962.2	4079925	4080560	R	Rv3641c, (MTCY15C10.11), len: 211 aa. Possible fic, cell filamentation protein, similar to others e.g. Q9PCU8|XF1657 CELL FILAMENTATION PROTEIN from Xylella fastidiosa (203 aa), FASTA scores: opt: 324, E(): 2.2e-14, (32.8% identity in 189 aa overlap); P20605|FIC_ECOLI|B3361 from Escherichia coli strain K12 (200 aa), FASTA scores: opt: 323, E(): 2.5e-14, (31.0% identity in 187 aa overlap); P20751|FIC_SALTY from Salmonella typhimurium (200 aa), FASTA scores: opt: 322, E(): 2.9e-14, (32.65% identity in 193 aa overlap); etc.; cell filamentation protein FIC	complement(4079925..4080560)	Mycobacterium tuberculosis H37Rv	885540
NP_218159.1	CDS	Rv3642c	NC_000962.2	4080571	4080765	R	Rv3642c, (MTCY15C10.10), len: 64 aa. Hypothetical unknown protein.; hypothetical protein	complement(4080571..4080765)	Mycobacterium tuberculosis H37Rv	885220
NP_218160.1	CDS	Rv3643	NC_000962.2	4081160	4081351	D	Rv3643, (MTCY15C10.09c), len: 63 aa (questionable ORF). Identical to AAK48106 from Mycobacterium tuberculosis strain CDC1551 (33 aa) but longer 30 aa.; hypothetical protein	4081160..4081351	Mycobacterium tuberculosis H37Rv	885600
NP_218161.1	CDS	Rv3644c	NC_000962.2	4081516	4082721	R	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta'	complement(4081516..4082721)	Mycobacterium tuberculosis H37Rv	885553
NP_218162.1	CDS	Rv3645	NC_000962.2	4082807	4084456	D	Rv3645, (MTCY15C10.07c), len: 549 aa. Probable conserved transmembrane protein, equivalent, but longer 20 aa, to O69547|ML0201|MLCB2548.30 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (530 aa), FASTA scores: opt: 2958, E(): 1.5e-168, (85.5% identity in 530 aa overlap). Also closely related to several other hypothetical M. tuberculosis proteins, e.g. Q10631|YD18_MYCTU|Rv1318c|MT1359|MTCY130.03c (541 aa) FASTA scores: opt: 1105, E(): 2.7e-58, (39.35% identity in 506 aa overlap); Q10633|YD20_MYCTU|Rv1320c|MT1362|MTCY130.05c (567 aa) FASTA scores: opt: 1031, E(): 7.1e-54, (38.1% identity in 509 aa overlap); Q10632|YD19_MYCTU|Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 1016, E(): 5.3e-53, (37.1% identity in 531 aa overlap); etc. Also similar at C-terminal end to many adenylate cyclases (EC 4.6.1.1) e.g. O83498|TP0485 from Treponema pallidum (614 aa) FASTA scores: opt: 365, E(): 3.2e-14, (31.55% identity in 317 aa overlap); P94180|CYAA from Anabaena sp. strain PCC 7120 (735 aa), FASTA scores: opt: 364, E(): 4.2e-14, (32.75% identity in 229 aa overlap); etc.; transmembrane protein	4082807..4084456	Mycobacterium tuberculosis H37Rv	885620
NP_218163.1	CDS	topA	NC_000962.2	4084453	4087257	R	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I	complement(4084453..4087257)	Mycobacterium tuberculosis H37Rv	885608
NP_218164.1	CDS	Rv3647c	NC_000962.2	4087610	4088188	R	Rv3647c, (MTCY15C10.05), len: 192 aa. Conserved hpothetical protein, equivalent to O69549|MLCB2548.32c|ML0199 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (200 aa), FASTA scores: opt: 1029, E(): 9e-58, (80.4% identity in 199 aa overlap).; hypothetical protein	complement(4087610..4088188)	Mycobacterium tuberculosis H37Rv	885217
NP_218165.1	CDS	cspA	NC_000962.2	4088328	4088531	R	Rv3648c, (MTCY15C10.04), len: 67 aa. Probable cspA, cold shock protein A, identical to O69550|CSPB|CSPA|ML0198 SMALL COLD-SHOCK PROTEIN from Mycobacterium leprae (67 aa) FASTA scores: opt: 451, E(): 3.7e-27, (97.0% identity in 67 aa overlap). Also highly similar to many e.g. Q9KGW0|CSPA from Mycobacterium smegmatis (67 aa) FASTA scores: opt: 439, E(): 2.9e-26, (92.55% identity in 67 aa overlap); P54584|CSP_ARTGO from Arthrobacter globiformis (67 aa), FASTA scores: opt: 335, E(): 1.5e-18, (73.45% identity in 64 aa overlap); O30875|CSPA_MICLU from Micrococcus luteus (Micrococcus lysodeikticus); Q9Z5R4|CSPA_BORPE from Bordetella pertussis (67 aa) FASTA scores: opt: 294, E(): 1.7e-15, (59.7% identity in 67 aa overlap); etc. Contains 'cold-shock' DNA-binding domain signature (PS00352) at N-terminal end. BELONGS TO THE COLD-SHOCK DOMAIN (CSD) FAMILY.; cold shock protein A	complement(4088328..4088531)	Mycobacterium tuberculosis H37Rv	885837
NP_218166.1	CDS	Rv3649	NC_000962.2	4088781	4091096	D	Rv3649, (MTCY15C10.03c), len: 771 aa. Probable helicase (EC 3.6.-.-), similar to many (known or hypothetical) ATP-dependent helicases e.g. Q9X915|SCH5.13 PUTATIVE HELICASE from Streptomyces coelicolor (815 aa) FASTA scores: opt: 2550, E(): 9.6e-139, (52.45% identity in 774 aa overlap); Q05549|YDR291W|D9819.1 PROTEIN SIMILAR TO SEVERAL DNA HELICASES from Saccharomyces cerevisiae (Baker's yeast) (1077 aa), FASTA scores: opt: 1161, E(): 5.9e-59, (31.05% identity in 780 aa overlap); P50830|YPRA_BACSU HYPOTHETICAL HELICASE from Bacillus subtilis (749 aa), FASTA scores: opt: 1154, E(): 1.1e-58, (34.05% identity in 734 aa overlap); Q9KC10|BH1764 ATP-DEPENDENT RNA HELICASE from Bacillus halodurans (764 aa), FASTA scores: opt: 1122, E(): 8e-57, (32.3% identity in 759 aa overlap); etc. SEEMS SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY, AND TO HELICASE C-TERMINAL DOMAIN.; helicase	4088781..4091096	Mycobacterium tuberculosis H37Rv	885841
YP_178000.1	CDS	PE33	NC_000962.2	4091233	4091517	D	Rv3650, (MTCY15C10.02c), len: 94 aa. Short protein, member of the Mycobacterium tuberculosis PE family (see citation below), but without the repetitive gly-rich region, similar to the N-terminal part of many e.g. O53809|Rv0746|MTV041.20 PGRS-FAMILY PROTEIN (783 aa), FASTA scores: opt: 363, E(): 2.1e-15, (76.55% identity in 81 aa overlap).; PE family protein	4091233..4091517	Mycobacterium tuberculosis H37Rv	885832
NP_218168.1	CDS	Rv3651	NC_000962.2	4091841	4092878	D	Rv3651, (MTCY15C10.01c), len: 345 aa. Hypothetical protein, with some similarity to Q9ZHK1 HYPOTHETICAL 36.5 KDA PROTEIN from Rhodococcus sp. X309 (329 aa) FASTA scores: opt: 332, E(): 3.4e-13, (27.4% identity in 321 aa overlap).; hypothetical protein	4091841..4092878	Mycobacterium tuberculosis H37Rv	885296
YP_178001.1	CDS	PE_PGRS60	NC_000962.2	4093632	4093946	D	Rv3652, (MTV025.001A), len: 104 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar at N-terminal end with many e.g. P56877|Y278_MYCTU|Rv0278c|MTV035.06c (957 aa) FASTA scores: opt: 242, E(): 3e-09, (77.35% identity in 53 aa overlap). Originally annotated as the first part of a PE-PGRS family protein (Rv3653/PE_PGRS61 being the second part) but more similar to a PE family protein. Length extended since first submission (+50 aa).; PE-PGRS family-related protein	4093632..4093946	Mycobacterium tuberculosis H37Rv	886260
YP_178002.1	CDS	PE_PGRS61	NC_000962.2	4093940	4094527	D	Rv3653, (MTV025.001B), len: 195 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to the C-termini of members of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, e.g. MTCY1A11_25, MTCY28_25, MTCY130_10, MTCY1A10_19, MTCY21B4_13, MTCI418B_6,MTCY28_34, MTV004_1, MTCY441_4; etc. Originally annotated as the second part of a PE-PGRS family protein (Rv3652/PE_PGRS60 being the first part). Start shortened since first submission (-50 aa). TBparse score is 0.886.; PE-PGRS family-related protein	4093940..4094527	Mycobacterium tuberculosis H37Rv	886259
NP_218171.1	CDS	Rv3654c	NC_000962.2	4094660	4094914	R	Rv3654c, (MTV025.002c), len: 84 aa. Hypothetical protein, similar to C-terminus of Q9X916|SCH5.14c MEMBRANE SPANNING PROTEIN from Streptomyces coelicolor (230 aa) FASTA scores: opt: 176, E(): 2.4e-05, (47.0% identity in 83 aa overlap). Equivalent to AAK48118 from Mycobacterium tuberculosis strain CDC1551 but shorter 18 aa. TBparse score is 0.872.; hypothetical protein	complement(4094660..4094914)	Mycobacterium tuberculosis H37Rv	885612
NP_218172.1	CDS	Rv3655c	NC_000962.2	4094923	4095300	R	Rv3655c, (MTV025.003c), len: 125 aa. Hypothetical protein, with similarity to Q9X917|SCH5.15c HYPOTHETICAL 15.2 KDA PROTEIN from Streptomyces coelicolor (150 aa) FASTA scores: opt: 211, E(): 7.7e-07, (39.65% identity in 111 aa overlap). Equivalent to AAK48119 from Mycobacterium tuberculosis strain CDC1551 (99 aa) but longer 26 aa at the C-terminus. TBparse score is 0.912.; hypothetical protein	complement(4094923..4095300)	Mycobacterium tuberculosis H37Rv	885614
NP_218173.1	CDS	Rv3656c	NC_000962.2	4095324	4095530	R	Rv3656c, (MTV025.004c), len: 68 aa. Conserved hypothetical protein, similar to Q9X918|SCH5.16c SMALL HYPOTHETICAL PROTEIN from Streptomyces coelicolor (75 aa), FASTA scores: opt: 129, E(): 0.0039, (40.0% identity in 60 aa overlap). Equivalent to AAK48120 from Mycobacterium tuberculosis strain CDC1551 (42 aa) but longer 26 aa. TBparse score is 0.869.; hypothetical protein	complement(4095324..4095530)	Mycobacterium tuberculosis H37Rv	885624
NP_218174.1	CDS	Rv3657c	NC_000962.2	4095540	4096115	R	Rv3657c, (MTV025.005c), len: 191 aa. Possible conserved membrane protein, rich in ala residues, similar to Q9X919|SCH5.17c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (267 aa), FASTA scores: opt: 324, E(): 4.7e-12, (40.9% identity in 154 aa overlap). TBparse score is 0.893.; hypothetical protein	complement(4095540..4096115)	Mycobacterium tuberculosis H37Rv	885619
NP_218175.1	CDS	Rv3658c	NC_000962.2	4096139	4096939	R	Rv3658c, (MTV025.006c), len: 266 aa. Probable conserved transmembrane protein, similar to Q9X920|SCH5.18c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (321 aa), FASTA scores: opt: 335, E(): 4.1e-13, (38.05% identity in 247 aa overlap). TBparse score is 0.913.; transmembrane protein	complement(4096139..4096939)	Mycobacterium tuberculosis H37Rv	885618
YP_178003.1	CDS	Rv3659c	NC_000962.2	4096936	4097994	R	Rv3659c, (MTV025.007c), len: 352 aa. Conserved hypothetical protein, highly similar, but always shorter (various lengths) at N-terminus, to Q9X921|SCH5.19c PUTATIVE SECRETORY PROTEIN from Streptomyces coelicolor (523 aa), FASTA scores: opt: 1287, E(): 5.3e-66, (59.85% identity in 351 aa overlap); Q9HW98|PA4302 PROBABLE TYPE II SECRETION SYSTEM PROTEIN from Pseudomonas aeruginosa (421 aa), FASTA scores: opt: 776, E(): 5.4e-37, (42.8% identity in 320 aa overlap); AAK65510|CPAF2 PROBABLE CPAF2 PILUS ASSEMBLY PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (497 aa) FASTA scores: opt: 769, E(): 1.5e-36, (40.45% identity in 309 aa overlap); Q9KY93|SCK15.11 PUTATIVE SECRETORY PROTEIN from Streptomyces coelicolor (445 aa), FASTA scores: opt: 751, E(): 1.5e-35, (38.15% identity in 333 aa overlap); etc. Contains PS00017 ATP/GTP binding site motif A (P-loop). Note that previously known as trbB. TBparse score is 0.906.; trbB; hypothetical protein	complement(4096936..4097994)	Mycobacterium tuberculosis H37Rv	885627
NP_218177.1	CDS	Rv3660c	NC_000962.2	4098096	4099148	R	Rv3660c, (MTV025.008c), len: 350 aa. Conserved hypothetical protein, similar to O33612 PROTEIN CONCERNED IN INHIBITION OF MORPHOLOGICAL DIFFERENTIATION IN Streptomyces azureus from Streptomyces cyaneus (Streptomyces curacoi) (370 aa), FASTA scores: opt: 655, E(): 5.9e-31, (42.2% identity in 315 aa overlap); Q9X922|SCH5.20c PUTATIVE SEPTUM SITE DETERMINING PROTEIN from Streptomyces coelicolor (396 aa), FASTA scores: opt: 592, E(): 2.9e-27, (43.25% identity in 275 aa overlap). And shows some similarity to AAK65513|CPAE2 PROBABLE CPAE2 PILUS ASSEMBLY PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (586 aa) FASTA scores: opt: 212, E(): 5.1e-05, (25.75% identity in 295 aa overlap); and several cell division inhibitors or septum site-determining proteins. Equivalent to AAK48124 from Mycobacterium tuberculosis strain CDC1551 (261 aa) but longer 89 aa.; hypothetical protein	complement(4098096..4099148)	Mycobacterium tuberculosis H37Rv	885319
NP_218178.1	CDS	Rv3661	NC_000962.2	4099647	4100510	D	Rv3661, (MTV025.009), len: 287 aa. Conserved hypothetical protein, highly similar to O33611|IMD_STRCN from Streptomyces cyaneus (Streptomyces curacoi) protein involved in inhibition of morphological differentiation in Streptomyces azureus (BELONGS TO THE SERB FAMILY) (277 aa) FASTA scores: opt: 1073, E(): 3.5e-61, (61.45% identity in 262 aa overlap); and Q9X923|SCH5.21 PUTATIVE MORPHOLOGICAL DIFFERENTIATION-ASSOCIATED PROTEIN from Streptomyces coelicolor (268 aa), FASTA scores: opt: 1057, E(): 3.6e-60, (61.45% identity in 262 aa overlap). Also similar to various bacterial proteins (principally serB-related proteins) e.g. Q49823|ML2424 HYPOTHETICAL SERB PROTEIN from Mycobacterium leprae (300 aa), FASTA scores: opt: 452, E(): 1.4e-21, (35.8% identity in 257 aa overlap); Q9WX12|SCE68.20 HYPOTHETICAL 32.0 KDA PROTEIN from Streptomyces coelicolor (298 aa), FASTA scores: opt: 415, E(): 3.1e-19, (33.55% identity in 280 aa overlap); Q9RIT2|SERB PHOSPHOSERINE PHOSPHATASE (FRAGMENT) from Streptomyces coelicolor (266 aa), FASTA scores: opt: 405, E(): 1.2e-18, (34.1% identity in 261 aa overlap); etc. Also similar to Q11169|Y505_MYCTU|Rv0505c|MTCY20G9.32c HYPOTHETICAL 39.5 KDA PROTEIN from Mycobacterium tuberculosis (373 aa), FASTA scores: opt: 454, E(): 1.2e-21, (35.15% identity in 276 aa overlap). BELONGS TO THE SERB FAMILY.; hypothetical protein	4099647..4100510	Mycobacterium tuberculosis H37Rv	885316
NP_218179.1	CDS	Rv3662c	NC_000962.2	4101265	4102035	R	Rv3662c, (MTV025.010c), len: 256 aa. Conserved hypothetical protein, equivalent to Q9CB99|ML2289 HYPOTHETICAL PROTEIN from Mycobacterium leprae (256 aa) FASTA scores: opt: 1255, E(): 3.3e-69, (78.05% identity in 255 aa overlap). Also similar to Q9X924|SCH5.22c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (274 aa), FASTA scores: opt: 289, E(): 1.8e-10, (39.25% identity in 270 aa overlap).; hypothetical protein	complement(4101265..4102035)	Mycobacterium tuberculosis H37Rv	885178
NP_218180.1	CDS	dppD	NC_000962.2	4102032	4103678	R	Rv3663c, (MTV025.011c), len: 548 aa. Probable dppD, dipeptide-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. AAK65441|SMA1434 PROBABLE ABC TRANSPORTER ATP-BINDING PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (550 aa), FASTA scores: opt: 1528, E(): 1e-78, (46.25% identity in 545 aa overlap); O50270|MOAD MOAD PROTEIN from Agrobacterium radiobacter (588 aa), FASTA scores: opt: 1354, E(): 6.7e-69, (42.9% identity in 541 aa overlap); Q9KM01|VCA0588 PUTATIVE PEPTIDE ABC TRANSPORTER ATP-BINDING PROTEIN from Vibrio cholerae (530 aa), FASTA scores: opt: 951, E(): 3.1e-46, (44.0% identity in 534 aa overlap); BAB49448|MLR2279 ATP-BINDING PROTEIN OF PEPTIDE ABC TRANSPORTER from Rhizobium loti (Mesorhizobium loti) (604 aa), FASTA scores: opt: 949, E(): 4.4e-46, (41.55% identity in 544 aa overlap); etc. Contains 2 PS00211 ABC transporters family signature, and 2 PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; peptide ABC transporter ATP-binding protein	complement(4102032..4103678)	Mycobacterium tuberculosis H37Rv	885039
NP_218181.1	CDS	dppC	NC_000962.2	4103675	4104475	R	Rv3664c, (MTV025.012c), len: 266 aa. Probable dppC, dipeptide-transport integral membrane protein ABC-transporter (see citation below), similar to many peptide permeases e.g. Q9F351|SC9E12.04 PUTATIVE PEPTIDE TRANSPORT SYSTEM INTEGRAL MEMBRANE from Streptomyces coelicolor (305 aa), FASTA scores: opt: 901, E(): 1.1e-47, (51.15% identity in 262 aa overlap); Q9KFX1|APPC|BH0349 OLIGOPEPTIDE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (305 aa), FASTA scores: opt: 652, E(): 1.5e-32, (35.55% identity in 270 aa overlap); P94312|DPPC_BACFI DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus firmus (304 aa), FASTA scores: opt: 642, E(): 5.9e-32, (35.75% identity in 263 aa overlap); P24139|OPPC_BACSU|SPO0KC OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (305 aa), FASTA scores: opt: 637, E(): 1.2e-31, (37.4% identity in 262 aa overlap); P26904|DPPC_BACSU|DCIAC DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (320 aa), FASTA scores: opt: 621, E(): 1.2e-30, (39.9% identity in 263 aa overlap); etc. HAS SIMILARITY WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS. BELONGS TO THE OPPBC SUBFAMILY.; peptide ABC transporter transmembrane protein	complement(4103675..4104475)	Mycobacterium tuberculosis H37Rv	885483
NP_218182.1	CDS	dppB	NC_000962.2	4104531	4105457	R	Rv3665c, (MTV025.013c), len: 308 aa. Probable dppB, dipeptide-transport integral membrane protein ABC-transporter (see citation below), similar to many peptide permeases e.g. Q9F352|SC9E12.03 PUTATIVE PEPTIDE TRANSPORT SYSTEM INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (307 aa), FASTA scores: opt: 1145, E(): 1.8e-61, (57.65% identity in 307 aa overlap); Q53191|Y4TP_RHISN PROBABLE PEPTIDE ABC TRANSPORTER PERMEASE PROTEIN Rhizobium sp. strain NGR234 (313 aa), FASTA scores: opt: 653, E(): 5.2e-32, (31.2% identity in 314 aa overlap); P24138|OPPB_BACSU OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE from Bacillus subtilis (311 aa), FASTA scores: opt: 643, E(): 2.1e-31, (33.45% identity in 305 aa overlap); etc. BELONGS TO THE OPPBC SUBFAMILY.; peptide ABC transporter transmembrane protein	complement(4104531..4105457)	Mycobacterium tuberculosis H37Rv	885474
NP_218183.1	CDS	dppA	NC_000962.2	4105459	4107084	R	Rv3666c, (MTV025.014c), len: 541 aa. Probable dppA, dipeptide-binding lipoprotein component of dipeptide transport system (see citation below), similar to many substrate-binding proteins e.g. Q9F353|SC9E12.02 PUTATIVE PEPTIDE TRANSPORT SYSTEM SECRETED PEPTIDE-BINDING PROTEIN from Streptomyces coelicolor (544 aa), FASTA scores: opt: 1200, E(): 9e-67, (39.2% identity in 538 aa overlap); P24141|OPPA_BACSU OLIGOPEPTIDE-BINDING PROTEIN from Bacillus subtilis (545 aa), FASTA scores: opt: 523, E(): 7.9e-25, (26.15% identity in 516 aa overlap); P23843|OPPA_ECOLI PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN from Escherichia coli (543 aa), FASTA scores: opt: 452, E(): 2e-20, (25.9% identity in 529 aa overlap); etc. Contains probable N-terminal signal sequence.; periplasmic dipeptide-binding lipoprotein DppA	complement(4105459..4107084)	Mycobacterium tuberculosis H37Rv	885315
NP_218184.1	CDS	acs	NC_000962.2	4107792	4109747	D	Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase	4107792..4109747	Mycobacterium tuberculosis H37Rv	885479
NP_218185.1	CDS	Rv3668c	NC_000962.2	4109783	4110481	R	Rv3668c, (MTV025.016c), len: 232 aa. Possible protease (EC 3.4.-.-) (and more specifically a putative alkaline serine protease (EC 3.4.21.-), equivalent to Q9CB98|ML2295 HYPOTHETICAL PROTEIN from Mycobacterium leprae (234 aa), FASTA scores: opt: 1249, E(): 7.4e-66, (77.5% identity in 231 aa overlap). Also similar at C-terminal end with many proteases e.g. O86984 ALKALINE SERINE PROTEASE PRECURSOR from Thermomonospora fusca (368 aa), FASTA scores: opt: 190, E(): 0.00056, (28.9% identity in 173 aa overlap); Q55353|SAPII ALKALINE SERINE PROTEASE II from Streptomyces sp (382 aa), FASTA scores: opt: 160, E(): 0.032, (27.15% identity in 199 aa overlap); O54109|SC10A5.18 PUTATIVE SECRETED PROTEASE from Streptomyces coelicolor (411 aa), FASTA scores: opt: 155, E(): 0.066, (26.4% identity in 163 aa overlap); Q54392|SAL|SCI11.35C SERINE PROTEASE SAL PRECURSOR (300 aa), FASTA scores: opt: 153, E(): 0.068, (28.1% identity in 185 aa overlap); P00778|PRLA_LYSEN|ALPHA-LP ALPHA-LYTIC PROTEASE PRECURSOR (397 aa), FASTA scores: opt: 154, E(): 0.074, (26.75% identity in 172 aa overlap); etc. Also similar with Q50618|YI15_MYCTU|Rv1815|MT1863|MTCY1A11.28c HYPOTHETICAL 22.8 KDA PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 134, E(): 0.69, (30.95% identity in 181 aa overlap).; protease	complement(4109783..4110481)	Mycobacterium tuberculosis H37Rv	885609
NP_218186.1	CDS	Rv3669	NC_000962.2	4110827	4111345	D	Rv3669, (MTV025.017), len: 172 aa. Probable conserved transmembrane protein, equivalent to Q9CB97|ML2296 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (181 aa), FASTA scores: opt: 863, E(): 1.4e-47, (77.35% identity in 181 aa overlap). Also similar to two PUTATIVE INTEGRAL MEMBRANE TRANSPORT PROTEINS from Streptomyces coelicolor; Q9X930|SCH5.28 (162 aa) FASTA scores: opt: 265, E(): 6.3e-10, (37.4% identity in 155 aa overlap); and Q9X9W1|SCI7.29c (165 aa), FASTA scores: opt: 194, E(): 1.9e-05, (30.6% identity in 134 aa overlap). Contains two hydrophobic stretches in centre. TBparse score is 0.912.; transmembrane protein	4110827..4111345	Mycobacterium tuberculosis H37Rv	885626
NP_218187.1	CDS	ephE	NC_000962.2	4111346	4112329	D	Rv3670, (MTV025.018), len: 327 aa. Possible ephE, epoxide hydrolase (EC 3.3.2.3) (see citation below), equivalent to Q9CB96|ML2297 PUTATIVE HYDROLASE from Mycobacterium leprae (324 aa), FASTA scores: opt: 1799, E(): 7.2e-105, (80.55% identity in 324 aa overlap). Also similar to many hydrolases (epoxide hydrolases) and hypothetical proteins e.g. Q9X931|SCH5.29 PUTATIVE HYDROLASE from Streptomyces coelicolor (324 aa), FASTA scores: opt: 687, E(): 1.4e-35, (40.65% identity in 327 aa overlap); Q9RRE3|DR2549 EPOXIDE HYDROLASE-RELATED PROTEIN from Deinococcus radiodurans (278 aa), FASTA scores: opt: 321, E(): 8.2e-13, (32.15% identity in 311 aa overlap); Q9K3Q1|2SCG4.13 PUTATIVE HYDROLASE from Streptomyces coelicolor (292 aa), FASTA scores: opt: 295, E(): 3.5e-11, (30.18% identity in 275 aa overlap); Q9S7P1 EPOXIDE HYDROLASE from Oryza sativa (Rice) (322 aa), FASTA scores: opt: 289, E(): 9.1e-11, (28.7% identity in 338 aa overlap); O23227|C7A10.830|AT4G36530 EPOXIDE HYDROLASE from Arabidopsis thaliana (Mouse-ear cress) (378 aa) FASTA scores: opt: 287, E(): 1.4e-10, (26.1% identity in 272 aa overlap); Q21147|K02F3.6 EPOXIDE HYDROLASE from Caenorhabditis elegans (386 aa), FASTA scores: opt: 283, E(): 2.5e-10, (33.35% identity in 156 aa overlap); etc. Also similar to P95276|EPHB|Rv1938|MTCY09F9.26c from Mycobacterium tuberculosis (356 aa), FASTA scores: opt: 296, E(): 3.6e-11, (29.7% identity in 340 aa overlap). Contains PS00213 Lipocalin signature. SIMILAR TO ALPHA/BETA HYDROLASE FOLD.; epoxide hydrolase EphE	4111346..4112329	Mycobacterium tuberculosis H37Rv	885577
NP_218188.1	CDS	Rv3671c	NC_000962.2	4112322	4113515	R	Rv3671c, (MTV025.019c), len: 397 aa. Possible serine protease membrane protein (EC 3.4.21.-), equivalent to Q9CB95|ML2298 PUTATIVE MEMBRANE-ASSOCIATED SERINE PROTEASE from Mycobacterium leprae (401 aa), FASTA scores: opt: 2061, E(): 2.3e-108, (80.9% identity in 398 aa overlap). Also similar to many serine proteases, but generally with extended N-terminus, e.g. Q9X932|SCH5.30c PUTATIVE SERINE PROTEASE (FRAGMENT) from Streptomyces coelicolor (385 aa), FASTA scores: opt: 835, E(): 1.2e-39, (39.9% identity in 386 aa overlap); Q9Z6T0|DEGP_CHLPN|HTRA|CPN0979|CP0877 PROBABLE SERINE PROTEASE DO-LIKE PRECURSOR from Chlamydia pneumoniae (Chlamydophila pneumoniae) (488 aa), FASTA scores: opt: 285, E(): 1e-08, (29.05% identity in 296 aa overlap); P73354|HTRA|SLR1204 SERINE PROTEASE from Synechocystis sp. strain PCC 6803 (452 aa), FASTA scores: opt: 284, E(): 1.1e-08, (29.55% identity in 308 aa overlap); Q9RWC4|DR0745 PERIPLASMIC SERINE PROTEASE, HTRA/DEGQ/DEGS FAMILY from Deinococcus radiodurans (366 aa), FASTA scores: opt: 271, E(): 4.9e-08, (35.45% identity in 206 aa overlap); etc. Also similar, but longer 114 aa at the N-terminus, to Q9S2P8|SC5F7.13 PUTATIVE PEPTIDASE from Streptomyces coelicolor (282 aa), FASTA scores: opt: 594, E(): 3.1e-26, (38.95% identity in 285 aa overlap). And similar, but longer 146 aa at the N-terminus, to O07175|PEPA|Rv0125|MTCI418B.07 from Mycobacterium tuberculosis (355 aa), FASTA scores: opt: 295, E(): 2.2e-09, (29.55% identity in 254 aa overlap); and Q9CCY9|ML2659 PROBABLE SECRETED SERINE PROTEASE from Mycobacterium leprae FASTA scores: opt: 286, E(): 6.9e-09, (30.6% identity in 255 aa overlap). Contains PS00135 Serine proteases, trypsin family, serine active site.; membrane-associated serine protease	complement(4112322..4113515)	Mycobacterium tuberculosis H37Rv	885176
NP_218189.1	CDS	Rv3672c	NC_000962.2	4113521	4114342	R	Rv3672c, (MTV025.020c), len: 273 aa. Conserved hypothetical protein, equivalent to Q9CB94|ML2299 HYPOTHETICAL PROTEIN from Mycobacterium leprae (266 aa) FASTA scores: opt: 1358, E(): 5.2e-75, (76.4% identity in 267 aa overlap). Also similar to others (generally in C-terminal end) e.g. Q9XA45|SCH17.02c HYPOTHETICAL 26.5 KDA PROTEIN from Streptomyces coelicolor (247 aa) FASTA scores: opt: 524, E(): 1.3e-24, (42.65% identity in 251 aa overlap); Q9AB27|CC0407 MUTT/NUDIX FAMILY PROTEIN from Caulobacter crescentus (216 aa), FASTA scores: opt: 285, E(): 3.2e-10, (36.2% identity in 174 aa overlap); BAB49788|MLL2727|Q98HS8 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (204 aa), FASTA scores: opt: 278, E(): 8.1e-10, (31.45% identity in 151 aa overlap); P43337|YEAB_ECOLI|B1813 HYPOTHETICAL 21.4 KDA PROTEIN from Escherichia coli strain K12 (192 aa) FASTA scores: opt: 252, E(): 2.9e-08, (35.9% identity in 170 aa overlap); etc. Contains PS01293 Uncharacterized protein family UPF0036 signature, LLT.; hypothetical protein	complement(4113521..4114342)	Mycobacterium tuberculosis H37Rv	885463
NP_218190.1	CDS	Rv3673c	NC_000962.2	4114474	4115157	R	Rv3673c, (MTV025.021c), len: 227 aa. Possible membrane protein, thioredoxin-like protein (thiol-disulfide interchange protein) (EC 1.-.-.-), equivalent to Q9CB93|ML2300 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (215 aa), FASTA scores: opt: 978, E(): 2.5e-52, (71.15% identity in 215 aa overlap). Some similarity with thioredoxin-related proteins e.g. P35160|RESA_BACSU RESA PROTEIN from Bacillus subtilis (181 aa), FASTA scores: opt: 212, E(): 5.7e-06, (30.55% identity in 108 aa overlap); Q9RXW6|DR0189 THIOL:DISULFIDE INTERCHANGE PROTEIN from Deinococcus radiodurans (185 aa) FASTA scores: opt: 206, E(): 1.3e-05, (33.8% identity in 139 aa overlap); Q9I505|PA0953 PROBABLE THIOREDOXIN from Pseudomonas aeruginosa (154 aa), FASTA scores: opt: 180, E(): 0.00044, (34.85% identity in 109 aa overlap); Q9KCP7|BH1522 THIOREDOXIN (THIOL:DISULFIDE INTERCHANGE PROTEIN) from Bacillus halodurans (177 aa), FASTA scores: opt: 178, E(): 0.00064, (31.75% identity in 107 aa overlap); P43221|TLPA_BRAJA THIOL:DISULFIDE INTERCHANGE PROTEIN (CYTOCHROME C BIOGENESIS PROTEIN) from Bradyrhizobium japonicum (221 aa), FASTA scores: opt: 189, E(): 0.00017, (26.85% identity in 227 aa overlap); etc. Also similar to O06392|Rv0526|MTCY25D10.05 HYPOTHETICAL 23.2 KDA PROTEIN from Mycobacterium tuberculosis (216 aa) FASTA scores: opt: 160, E(): 0.0093, (27.45% identity in 142 aa overlap). Contains PS00194 Thioredoxin family active site. POSSIBLY BELONGS TO THE THIOREDOXIN FAMILY.; membrane-anchored thioredoxin-like protein	complement(4114474..4115157)	Mycobacterium tuberculosis H37Rv	885190
NP_218191.2	CDS	nth	NC_000962.2	4115157	4115894	R	Rv3674c, (MT3775, MTV025.022c), len: 245 aa. Probable nth, endonuclease III (EC 4.2.99.18) (see citation below), equivalent to Q9CB92|NTH|ML2301 PUTATIVE ENDONUCLEASE III from Mycobacterium leprae (272 aa), FASTA scores: opt: 1363, E(): 3.6e-81, (89.4% identity in 226 aa overlap). Also similar to many e.g. Q9XA44|SCH17.03c from Streptomyces coelicolor (250 aa), FASTA scores: opt: 937, E(): 2.2e-55, (61.65% identity in 219 aa overlap); P46303|UVEN_MICLU from Micrococcus luteus (Micrococcus lysodeikticus) (279 aa), FASTA scores: opt: 899, E(): 8.1e-53, (58.45% identity in 248 aa overlap); P73715|END3_SYNY3|NTH|SLR1822 from Synechocystis sp. strain PCC 6803 (219 aa), FASTA scores: opt: 684, E(): 1.7e-38, (52.2% identity in 203 aa overlap); P39788|END3_BACSU|NTH|JOOB from Bacillus subtilis (219 aa), FASTA scores: opt: 552, E(): 1.2e-29, (43.3% identity in 194 aa overlap); etc. Equivalent to AAK48142 from Mycobacterium tuberculosis strain CDC1551 (262 aa) but shorter 17 aa. Contains PS00764 Endonuclease III iron-sulfur binding region signature, and PS01155 Endonuclease III family signature. BELONGS TO THE NTH/MUTY FAMILY. COFACTOR: BINDS A 4FE-4S CLUSTER WHICH IS NOT IMPORTANT FOR THE CATALYTIC ACTIVITY, BUT WHICH IS PROBABLY INVOLVED IN THE PROPER POSITIONING OF THE ENZYME ALONG THE DNA STRAND (BY SIMILARITY). N-terminus extended since first submission (previously 226 aa).; endonuclease III	complement(4115157..4115894)	Mycobacterium tuberculosis H37Rv	885058
NP_218192.1	CDS	Rv3675	NC_000962.2	4116002	4116379	D	Rv3675, (MTV025.023), len: 125 aa. Possible membrane protein, with some similarity to Q9YCZ2|APE1120 HYPOTHETICAL 11.7 KDA PROTEIN from Aeropyrum pernix (103 aa), FASTA scores: opt: 100, E(): 9, (40.0% identity in 55 aa overlap).; hypothetical protein	4116002..4116379	Mycobacterium tuberculosis H37Rv	885155
NP_218193.1	CDS	Rv3676	NC_000962.2	4116478	4117152	D	Rv3676, (MTV025.024), len: 224 aa. Probable transcriptional regulator belonging to crp/fnr family, identical to Q9CB91|ML2302 PUTATIVE CRP/FNR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (224 aa), FASTA scores: opt: 1408, E(): 8.8e-81, (95.95% identity in 224 aa overlap). Also highly similar to transcriptional regulators AAK58838 from Corynebacterium glutamicum (Brevibacterium flavum) (227 aa), FASTA scores: opt: 1178, E(): 1.9e-66, (79.9% identity in 224 aa overlap); and Q9XA42|SCH17.05 from Streptomyces coelicolor (224 aa), FASTA scores: opt: 869, E(): 3.4e-47, (54.45% identity in 224 aa overlap); and similar to others e.g. Q9RRX0|DR2362 from Deinococcus radiodurans (231 aa) FASTA scores: opt: 344, E(): 1.8e-14, (30.8% identity in 211 aa overlap); P29281|CRP_HAEIN from Haemophilus influenzae (224 aa), FASTA scores: opt: 330, E(): 1.3e-13, (32.25% identity in 189 aa overlap); P03020|CRP_ECOLI|CAP|CSM|B3357 from Escherichia coli strain K12 and Shigella flexneri (210 aa), FASTA scores: opt: 323, E(): 3.5e-13, (32.25% identity in 189 aa overlap); etc. Contains helix-turn-helix motif at aa 175-196 (Score 1990, +5.96 SD). BELONGS TO THE CRP/FNR FAMILY OF TRANSCRIPTIONAL REGULATORS.; CRP/FNR family transcriptional regulator	4116478..4117152	Mycobacterium tuberculosis H37Rv	885502
NP_218194.1	CDS	Rv3677c	NC_000962.2	4117258	4118052	R	Rv3677c, (MTV025.025c), len: 264 aa. Possible hydrolase (EC 3.-.-.-), equivalent to Q9CB90|ML2303 PUTATIVE HYDROLASE from Mycobacterium leprae (262 aa) FASTA scores: opt: 1400, E(): 8.5e-81, (82.05% identity in 262 aa overlap). Also similar to other hydrolases and hypothetical proteins e.g. Q9XA41|SCH17.06c PUTATIVE HYDROLASE from Streptomyces coelicolor (256 aa) FASTA scores: opt: 609, E(): 3.9e-31, (54.65% identity in 247 aa overlap); Q9A9Q1|CC0923 METALLO-BETA-LACTAMASE FAMILY PROTEIN from Caulobacter crescentus (297 aa), FASTA scores: opt: 306, E(): 4.7e-12, (35.45% identity in 268 aa overlap); Q9Y392 CGI-83 PROTEIN from Homo sapiens (Human) (288 aa), FASTA scores: opt: 281, E(): 1.7e-10, (33.2% identity in 259 aa overlap); Q9F7R6 PREDICTED METALLOBETA LACTAMASE FOLD PROTEIN from uncultured proteobacterium EBAC31A08 (265 aa), FASTA scores: opt: 257, E(): 5.1e-09, (32.55% identity in 252 aa overlap); Q9PBI4|XF2160 HYDROXYACYLGLUTATHIONE HYDROLASE from Xylella fastidiosa (258 aa), FASTA scores: opt: 232, E(): 1.9e-07, (30.3% identity in 165 aa overlap); etc.; hydrolase	complement(4117258..4118052)	Mycobacterium tuberculosis H37Rv	885079
NP_218195.1	CDS	Rv3678c	NC_000962.2	4118059	4118514	R	Rv3678c, (MTV025.026c), len: 151 aa. Conserved hypothetical protein, equivalent, but shorter 23 aa, to Q9CB89|ML2304 HYPOTHETICAL PROTEIN from Mycobacterium leprae (174 aa), FASTA scores: opt: 746, E(): 2.1e-40, (78.15% identity in 151 aa overlap). Also highly similar to many hypothetical proteins or transcription regulators e.g. Q9XA38|SCH17.09c from Streptomyces coelicolor (155 aa), FASTA scores: opt: 637, E(): 1.5e-33, (69.1% identity in 152 aa overlap); BAB48205|MLR0658 from Rhizobium loti (Mesorhizobium loti) (154 aa), FASTA scores: opt: 500, E(): 6.8e-25, (55.35% identity in 150 aa overlap); BAB50615|MLR3802 TRANSCRIPTION REGULATOR from Rhizobium loti (Mesorhizobium loti) (153 aa), FASTA scores: opt: 425,E(): 3.8e-20, (44.35% identity in 151 aa overlap); Q9U0W7|L7276.02 from Leishmania major (163 aa) FASTA scores: opt: 404, E(): 8.5e-19, (47.7% identity in 151 aa overlap); Q9UZA3|PAB0825 PUTATIVE TRANSLATION INITIATION INHIBITOR from Pyrococcus abyssi (127 aa), FASTA scores: opt: 108, E(): 3.7, (30.75% identity in 130 aa overlap); etc. Contains PS00044 Bacterial regulatory proteins, lysR family signature.; hypothetical protein	complement(4118059..4118514)	Mycobacterium tuberculosis H37Rv	885495
YP_178004.1	CDS	Rv3678A	NC_000962.2	4118530	4118691	R	Rv3678A, len: 53 aa. Conserved hypothetical protein, similar to SCH17.10|AL079353_10 conserved hypothetical protein from Streptomyces coelicolor (53 aa), FASTA scores: opt: 259, E(): 1.5e-13, (78.0% identity in 50 aa overlap).; hypothetical protein	complement(4118530..4118691)	Mycobacterium tuberculosis H37Rv	3205049
NP_218196.1	CDS	Rv3679	NC_000962.2	4118776	4119798	D	Rv3679, (MTV025.027), len: 340 aa. Probable anion transporting ATPase (EC 3.6.1.-), equivalent to Q9CB88|ML2305 PROBABLE ANION TRANSPORTER PROTEIN from Mycobacterium leprae (341 aa), FASTA scores: opt: 1810, E(): 2.1e-98, (84.15% identity in 341 aa overlap). Also highly similar to Q9XA36|SCH17.11 PUTATIVE ION-TRANSPORTING ATPASE from Streptomyces coelicolor (325 aa), FASTA scores: opt: 989, E(): 1.4e-50, (52.15% identity in 328 aa overlap); and similar to many anion transporting ATPases (principally arsenite transporters) e.g. O50593|ARSA_ACIMU ARSENICAL PUMP-DRIVING ATPASE (ARSENITE-TRANSLOCATING ATPASE) from Acidiphilium multivorum (583 aa), FASTA scores: opt: 225, E(): 8.1e-06, (25.1% identity in 319 aa overlap); AAG43231|ARSA ARSENITE ACITVATED ATPASE from Salmonella typhimurium plasmid R46 FASTA scores: opt: 211, E(): 5.3e-05, (26.95% identity in 267 aa overlap); P52145|ARA2_ECOLI|ARSA ARSENICAL PUMP-DRIVING ATPASE from Escherichia coli plasmid IncN R46 (583 aa), FASTA scores: opt: 211, E(): 5.3e-05, (26.95% identity in 267 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). SOME SIMILARITY TO THE ARSA ATPASE FAMILY.; anion transporter ATPase	4118776..4119798	Mycobacterium tuberculosis H37Rv	885809
NP_218197.1	CDS	Rv3680	NC_000962.2	4119795	4120955	D	Rv3680, (MTV025.028), len: 386 aa. Probable anion transporting ATPase (EC 3.6.1.-), equivalent to Q9CB87|ML2306 PROBABLE ANION TRANSPORTER PROTEIN from Mycobacterium leprae (381 aa), FASTA scores: opt: 2131, E(): 6.5e-120, (88.1% identity in 370 aa overlap). Also highly similar, but shorter 29 aa, to Q9XA35|SCH17.12 PUTATIVE ION-TRANSPORTING ATPASE from Streptomyces coelicolor (481 aa), FASTA scores: opt: 1190, E(): 1.1e-63, (51.25% identity in 441 aa overlap); and similar to many anion transporting ATPases e.g. Q9UZA6|PAB1555 ANION TRANSPORTING ATPASE from Pyrococcus abyssi (330 aa) FASTA scores: opt: 242, E(): 3e-07, (24.6% identity in 297 aa overlap); Q9P7F8|SPAC1142.06 PUTATIVE ARSENITE-TRANSLOCATING from Schizosaccharomyces pombe (Fission yeast) (329 aa), FASTA scores: opt: 239, E(): 4.5e-07, (27.9% identity in 197 aa overlap); Q9HS79|ARSA1|VNG0365G ARSENICAL PUMP-DRIVING ATPASE from Halobacterium sp. strain NRC-1 (347 aa), FASTA scores: opt: 238, E(): 5.4e-07, (29.35% identity in 358 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; anion transporter ATPase	4119795..4120955	Mycobacterium tuberculosis H37Rv	885317
NP_218198.2	CDS	whiB4	NC_000962.2	4121198	4121554	R	Rv3681c, (MTV025.029c), len: 118 aa. Probable whiB4 (alternate gene name: whmA), WhiB-like regulatory protein (see Hutter & Dick 1999), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to ML2307 HYPOTHETICAL PROTEIN from Mycobacterium leprae (116 aa). Also highly similar to Q9S2B9|SCH17.13c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (112 aa), FASTA scores: opt: 392, E(): 1e-20, (67.95% identity in 78 aa overlap); Q9X951|WBLA HYPOTHETICAL 14.3 KDA PROTEIN from Streptomyces coelicolor (129 aa), FASTA scores: opt: 392, E(): 1.1e-20, (67.95% identity in 78 aa overlap); Q9ACZ0|SCP1.161c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (268 aa), FASTA scores: opt: 273, E(): 4.4e-12, (50.0% identity in 78 aa overlap); Q06387|WHIB-STV from Streptomyces griseocarneus (87 aa) FASTA scores: opt: 231, E(): 1.5e-09, (43.85% identity in 73 aa overlap); etc. Also similar to several putative regulator proteins from Mycobacterium tuberculosis e.g. MTCY7D11_7; MTCY78_13; MTCY10H4_23; MTCY1A6_6; and U00016_29 from Mycobacterium leprae. N-terminus shortened since first submission.; whmA; transcriptional regulatory protein WHIB-like WHIB4	complement(4121198..4121554)	Mycobacterium tuberculosis H37Rv	885320
YP_178005.1	CDS	ponA2	NC_000962.2	4121916	4124348	D	(MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE)]; Rv3682, (MTV025.030), len: 810 aa. Probable ponA2, penicillin-binding protein (class A), bienzymatic membrane-associated protein with transglycosylase (EC 2.4.2.-) and transpeptidase (EC 3.4.-.-) activities. Almost identical to Q9CB85|PON1|ML2308 PENICILLIN BINDING PROTEIN (CLASS A) from Mycobacterium leprae (803 aa) FASTA scores: opt: 4743, E(): 3.3e-217, (87.7% identity in 806 aa overlap); or P72351|PON1|PBP1 HIGH-MOLECULAR-MASS CLASS A PENICILLIN BINDING PROTEIN from Mycobacterium leprae Cosmid B577 (821 aa), FASTA scores: opt: 4547, E(): 6.3e-208, (88.05% identity in 769 aa overlap) (see Basu et al., 1996). Also equivalent to a predicted homologous protein from Mycobacterium smegmatis. Also similar to others e.g. Q9XA34|SCH17.14 from Streptomyces coelicolor (428 aa; fragment), FASTA scores: opt: 727, E(): 2.3e-27, (36.55% identity in 413 aa overlap); Q9F9V7|PONA from Mycobacterium smegmatis (715 aa), FASTA scores: opt: 446, E(): 6.6e-14, (27.65% identity in 771 aa overlap) (see Billman-Jacobe et al., 1999); Q9CCY4|PONA|ML2688 from Mycobacterium leprae (708 aa), FASTA scores: opt: 413, E(): 2.4e-12, (26.8% identity in 660 aa overlap); Q9X6W0|PONB|MRCB|PA4700 from Pseudomonas aeruginosa (774 aa), FASTA scores: opt: 398, E(): 1.3e-11, (27.2% identity in 666 aa overlap); P45345|PBPB_HAEIN|MRCB|PONB|HI1725 (781 aa), FASTA scores: opt: 380, E(): 9.4e-11, (28.6% identity in 601 aa overlap); etc. Also similar to P71707|PONA1|Rv0050|MTCY21.13 PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B (PBP1) from Mycobacterium tuberculosis (678 aa) FASTA scores: opt: 372, E(): 2e-10, (28.35% identity in 769 aa overlap). SEEMS TO BELONG TO THE TRANSGLYCOSYLASE FAMILY IN THE N-TERMINAL SECTION, AND TO THE TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION; bifunctional membrane-associated penicillin-binding protein 1A/1B	4121916..4124348	Mycobacterium tuberculosis H37Rv	885751
NP_218200.1	CDS	Rv3683	NC_000962.2	4124417	4125376	D	Rv3683, (MTV025.031), len: 319 aa. Conserved hypothetical protein, equivalent to Q9CB84|ML2309 HYPOTHETICAL PROTEIN from Mycobacterium leprae (330 aa) FASTA scores: opt: 1791, E(): 9e-107, (85.45% identity in 296 aa overlap). Also similar to Q9X935|SCH66.03 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (309 aa) FASTA scores: opt: 610, E(): 1.4e-31, (51.45% identity in 307 aa overlap); and Q9RRY7|YN45_DEIRA|DR2345 HYPOTHETICAL PROTEIN from Deinococcus radiodurans (305 aa) FASTA scores: opt: 243, E(): 3.2e-08, (31.1% identity in 315 aa overlap) and some similarity to other hypothetical bacterial proteins e.g. Q9CF81|YQED from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (278 aa) FASTA scores: opt: 200, E(): 1.6e-05, (26.85% identity in 287 aa overlap).; hypothetical protein	4124417..4125376	Mycobacterium tuberculosis H37Rv	885780
NP_218201.1	CDS	Rv3684	NC_000962.2	4125439	4126479	D	Rv3684, (MTV025.032), len: 346 aa. Probable lyase (EC 4.-.-.-), and more specifically a cysteine synthase (EC 4.2.99.8), highly similar to many lyases e.g. Q9K3N2|SCG20A.08c PUTATIVE LYASE from Streptomyces coelicolor (374 aa), FASTA scores: opt: 1469, E(): 3.7e-85, (63.35% identity in 341 aa overlap) (shorter 31 aa at N-terminus); Q9KT44|VC1061 CYSTEINE SYNTHASE (EC 4.2.99.8)/CYSTATHIONINE BETA-SYNTHASE FAMILY PROTEIN from Vibrio cholerae (355 aa), FASTA scores: opt: 1366, E(): 1.1e-78, (63.25% identity in 321 aa overlap); Q9I4R3|PA1061 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (365 aa), FASTA scores: opt: 1311, E(): 3.2e-75, (59.8% identity in 341 aa overlap); Q9PH18|XF0128 CYSTEINE SYNTHASE from Xylella fastidiosa (390 aa), FASTA scores: opt: 1288, E(): 9.5e-74, (58.55% identity in 333 aa overlap) (shorter 34 aa at N-terminus); P55708|Y4XP_RHISN PUTATIVE CYSTEINE SYNTHASE from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (336 aa), FASTA scores: opt: 376, E(): 2.1e-16, (29.2% identity in 315 aa overlap); etc. Equivalent to AAK48153 from Mycobacterium tuberculosis strain CDC1551 (368 aa) but shorter 22 aa.; lyase	4125439..4126479	Mycobacterium tuberculosis H37Rv	885598
NP_218202.1	CDS	cyp137	NC_000962.2	4127295	4128725	R	Rv3685c, (MTV025.033c), len: 476 aa. Probable cyp137, cytochrome P-450 (EC 1.14.-.-), similar to many e.g. Q9VXY0|C4S3_DROME|CYP4S3|CG9081 from Drosophila melanogaster (Fruit fly) (495 aa), FASTA scores: opt: 376, E(): 1.2e-15, (28.35% identity in 413 aa overlap); Q59163|CYP110A2 from Anabaena variabilis (459 aa) FASTA scores: opt: 320, E(): 3.1e-12, (31.4% identity in 411 aa overlap); O23051|C883_ARATH from Arabidopsis thaliana (Mouse-ear cress) (490 aa), FASTA scores: opt: 313, E(): 8.8e-12, (28.25% identity in 425 aa overlap); etc. Also similar to many from Mycobacterium tuberculosis e.g. O53765|C13B_MYCTU|CYP135B1|Rv0568|MT0594|MTV039.06 (472 aa), FASTA scores: opt: 920, E(): 4.6e-49, (36.25% identity in 447 aa overlap); P96813|C138_MYCTU|CYP138|Rv0136|MT0144|MTCI5.10 (441 aa) FASTA scores: opt: 886, E(): 5.3e-47, (35.5% identity in 445 aa overlap); etc. BELONGS TO THE CYTOCHROME P450 FAMILY. TBparse score is 0.923.; cytochrome P450 137	complement(4127295..4128725)	Mycobacterium tuberculosis H37Rv	885625
NP_218203.1	CDS	Rv3686c	NC_000962.2	4128751	4129083	R	Rv3686c, (MTV025.034c), len: 110 aa. Hypothetical protein, similar to P96893|Rv3288c|MTCY71.28c HYPOTHETICAL 15.2 KDA PROTEIN from Mycobacterium tuberculosis (and Mycobacterium bovis) (137 aa) FASTA scores: opt: 106, E(): 5.6, (29.1% identity in 79 aa overlap); and a few hypothetical proteins e.g. Q9GUV6|L2259.2 from Leishmania major (360 aa) FASTA scores: opt: 118, E(): 2.1, (28.7% identity in 101 aa overlap). Equivalent to AAK48155 from Mycobacterium tuberculosis strain CDC1551 (166 aa) but shorter 56 aa.; hypothetical protein	complement(4128751..4129083)	Mycobacterium tuberculosis H37Rv	885306
NP_218204.1	CDS	rsfB	NC_000962.2	4129323	4129691	R	Rv3687c, (MTV025.035c), len: 122 aa. rsfB, anti-anti-sigma factor (see citation below), showing some similarity to sporulation proteins and sigma-factor genes e.g. Q9WVX8|RSBV_STRCO|BLDG|SCH5.12c ANTI-SIGMA B FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa) FASTA scores: opt: 163, E(): 0.0007, (31.15% identity in 106 aa overlap); Q9F3A2|SC5F1.27c PUTATIVE ANTI-SIGMA FACTOR ANTAGONIST from Streptomyces coelicolor (114 aa) FASTA scores: opt: 159, E(): 0.0013, (29.8% identity in 104 aa overlap); P73609|SLR1859 HYPOTHETICAL 12.0 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (108 aa) FASTA scores: opt: 152, E(): 0.0034, (32.2% identity in 90 aa overlap); L47358|BACSPOI_1 spoIIA A from Paenibacillus polymyxa (117 aa), FASTA scores: opt: 107, E(): 0.23, (24.8% identity in 113 aa overlap); SQSIGB_4 rsbU, rsbV, rsbW & sigB genes from Steptomyces aureus (108 aa) (28.3% identity in 60 aa overlap); etc. Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. MTCY180_14 and MTCY441 _8.; anti-anti-sigma factor RSFB (anti-sigma factor antagonist) (regulator of sigma F B)	complement(4129323..4129691)	Mycobacterium tuberculosis H37Rv	885599
NP_218205.1	CDS	Rv3688c	NC_000962.2	4129893	4130357	R	Rv3688c, (MTV025.036c), len: 139 aa. Hypothetical protein, similar to other bacterial hypothetical proteins e.g. Q9X934|SCH66.02c from Streptomyces coelicolor (154 aa), FASTA scores: opt: 425, E(): 3.4e-19, (46.1% identity in 154 aa overlap); Q9WZF4|TM0690 from Thermotoga maritima (149 aa), FASTA scores: opt: 326, E(): 3.4e-13, (40.4% identity in 151 aa overlap); Q9PHU3|CJ0573 from Campylobacter jejuni (147 aa), FASTA scores: opt:290 , E(): 5.1e-11, (36.4% identity in 151 aa overlap); etc. Also some similarity to upstream O69654|Rv3686c|MTV025.034c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis. TBparse score is 0.880.; hypothetical protein	complement(4129893..4130357)	Mycobacterium tuberculosis H37Rv	885563
NP_218206.1	CDS	Rv3689	NC_000962.2	4130357	4131712	D	Rv3689, (MTV025.037), len: 451 aa. Probable conserved transmembrane protein, with Proline rich N-terminus, similar to Q9KYW6|SCE33.17 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (462 aa) FASTA scores: opt: 730, E(): 2.7e-21, (38.1% identity in 412 aa overlap).; transmembrane protein	4130357..4131712	Mycobacterium tuberculosis H37Rv	885107
NP_218207.1	CDS	Rv3690	NC_000962.2	4131739	4132392	D	Rv3690, (MTV025.038), len: 217 aa. Probable conserved membrane protein, similar to Q9KYW5|SCE33.18 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (231 aa), FASTA scores: opt: 419, E(): 1.5e-19, (36.0% identity in 211 aa overlap). Equivalent to AAK48159 from Mycobacterium tuberculosis strain CDC1551 (233 aa) but shorter 16 aa. TBparse score is 0.903.; hypothetical protein	4131739..4132392	Mycobacterium tuberculosis H37Rv	885114
NP_218208.1	CDS	Rv3691	NC_000962.2	4132518	4133519	D	Rv3691, (MTV025.039), len: 333 aa. Conserved hypothetical protein, similar to Q9KYW4|SCE33.19 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (387 aa) FASTA scores: opt: 481, E(): 6e-23, (36.6% identity in 358 aa overlap). Equivalent to AAK48160 from Mycobacterium tuberculosis strain CDC1551 (381 aa) but shorter 48 aa. TBparse score is 0.931.; hypothetical protein	4132518..4133519	Mycobacterium tuberculosis H37Rv	885623
NP_218209.1	CDS	moxR2	NC_000962.2	4133516	4134592	D	Rv3692, (MTV025.040), len: 358 aa. Probable moxR2, methanol dehydrogenase regulatory protein, highly similar (generally longer at N-terminus) to Q9KYW3|SCE33.20 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (329 aa), FASTA scores: opt: 1523, E(): 4.2e-74, (70.9% identity in 330 aa overlap); Q9Z538|SC9B2.21c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (332 aa) FASTA scores: opt: 1008, E(): 1.1e-46, (50.8% identity in 313 aa overlap); Q9UZ67|MOXR-3|PAB0848 METHANOL DEHYDROGENASE REGULATORY PROTEIN from Pyrococcus abyssi (314 aa), FASTA scores: opt: 989, E(): 1.1e-45, (50.65% identity in 302 aa overlap); Q9AAN1|CC0566 MOXR PROTEIN from Caulobacter crescentus (323 aa), FASTA scores: opt: 988, E(): 1.3e-45, (52.3% identity in 306 aa overlap); etc. Also similar to O53170|MTV007.26|MOXR|Rv1479 from Mycobacterium tuberculosis (377 aa); and O07392|AF002133_6|MOXR from Mycobacterium avium (309 aa). Also high similarity with several hypothetical bacterial proteins. TBparse score is 0.912.; methanol dehydrogenase transcriptional regulatory protein MOXR2	4133516..4134592	Mycobacterium tuberculosis H37Rv	885323
NP_218210.1	CDS	Rv3693	NC_000962.2	4134726	4136048	D	Rv3693, (MTV025.041), len: 440 aa (alternative start at 41910). Possible conserved membrane protein, similar to Q9KYW2|SCE33.21 PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (436 aa), FASTA scores: opt: 875, E(): 3.3e-46, (56.25% identity in 448 aa overlap); Q9AAN0|CC0567 HYPOTHETICAL PROTEIN from Caulobacter crescentus (437 aa), FASTA scores: opt: 355, E(): 2.3e-14, (30.9% identity in 450 aa overlap); P73233|SLR2013 HYPOTHETICAL 48.5 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (435 aa), FASTA scores: opt: 340, E(): 1.9e-13, (29.7% identity in 438 aa overlap); etc. Equivalent to AAK48162 from Mycobacterium tuberculosis strain CDC1551 (475 aa) but shorter 35 aa. Also similar to other hypothetical proteins from Mycobacterium tuberculosis; MTV014_7; MTV007_27; and MTCY71_36 M.; hypothetical protein	4134726..4136048	Mycobacterium tuberculosis H37Rv	885059
NP_218211.1	CDS	Rv3694c	NC_000962.2	4136122	4137114	R	Rv3694c, (MTV025.042c), len: 330 aa. Possible conserved transmembrane protein, highly similar to Q9KZM4|SCE34.01c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (335 aa), FASTA scores: opt: 1113, E(): 2.5e-60, (51.5% identity in 334 aa overlap); and similar to Q9KEW6|BH0733 HYPOTHETICAL PROTEIN from Bacillus halodurans (355 aa), FASTA scores: opt: 381, E(): 6.1e-16, (24.15% identity in 331 aa overlap); Q9AAM9|CC0568 HYPOTHETICAL PROTEIN from Caulobacter crescentus (332 aa), FASTA scores: opt: 352, E(): 3.3e-14, (30.3% identity in 310 aa overlap); P74166|SLR1478 HYPOTHETICAL 35.4 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (317 aa), FASTA scores: opt: 330, E(): 6.8e-13, (25.65% identity in 308 aa overlap); etc. C-terminal end shows similarity to O29631|AF0624|AE001061_10 CONSERVED HYPOTHETICAL PROTEIN (putative nifU protein) from Archaeoglobus fulgidus (185 aa), FASTA scores: opt: 154, E(): 0.021, (29.0% identity in 131 aa overlap). Equivalent to AAK48163 from Mycobacterium tuberculosis strain CDC1551 (395 aa) but shorter 65 aa. Also some similarity to MTCY428_20 HYPOTHETICAL 43.7 KDA PROTEIN from Mycobacterium tuberculosis.; transmembrane protein	complement(4136122..4137114)	Mycobacterium tuberculosis H37Rv	885578
NP_218212.1	CDS	Rv3695	NC_000962.2	4137206	4138138	D	Rv3695, (MTV025.043), len: 310 aa. Possible conserved membrane protein, equivalent, but longer 88 aa, to Q9CB83|ML2312 POSSIBLE MEMBRANE PROTEIN from Mycobacterium leprae (196 aa), FASTA scores: opt: 898, E(): 5.2e-36, (71.05% identity in 190 aa overlap). Also highly similar to Q9KZM3|SCE34.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (318 aa), FASTA scores: opt: 740,E(): 2.4e-28, (43.25% identity in 319 aa overlap); and similar to P72718|SLR0254 HYPOTHETICAL 30.4 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (266 aa), FASTA scores: opt: 287, E(): 6.1e-07, (29.6% identity in 260 aa overlap); Q9HW83|PA4318 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 250, E(): 3.5e-05, (32.0% identity in 203 aa overlap); Q9KEW5|BH0734 HYPOTHETICAL PROTEIN from Bacillus halodurans (266 aa), FASTA scores: opt: 168, E(): 0.0047, (25.95% identity in 231 aa overlap); etc. C-terminal end shows some similarity to proline-rich proteins e.g. Q62106 PROLINE-RICH SALIVARY PROTEIN (FRAGMENT) from Mus musculus (Mouse) (188 aa) (36.1% identity in 97 aa overlap). Equivalent to AAK48164 from Mycobacterium tuberculosis strain CDC1551 (269 aa) but longer 41 aa.; hypothetical protein	4137206..4138138	Mycobacterium tuberculosis H37Rv	885538
NP_218213.1	CDS	glpK	NC_000962.2	4138202	4139755	R	Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase	complement(4138202..4139755)	Mycobacterium tuberculosis H37Rv	885280
NP_218214.1	CDS	Rv3697c	NC_000962.2	4139805	4140242	R	Rv3697c, (MTV025.045c), len: 145 aa. Possible conserved membrane protein, similar to many proteins from Mycobacterium tuberculosis e.g. Q10800|YS72_MYCTU|Rv2872|MT2939|MTCY274.03 (147 aa) FASTA scores: opt: 223, E(): 7.3e-08, (32.6% identity in 141 aa overlap); O53501|Rv2103c|MTV020.03 (144 aa), FASTA scores: opt: 215, E(): 2.4e-07, (31.4% identity in 137 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 192, E(): 7.6e-06, (31.25% identity in 144 aa overlap); etc.; hypothetical protein	complement(4139805..4140242)	Mycobacterium tuberculosis H37Rv	885492
NP_218215.1	CDS	Rv3698	NC_000962.2	4140493	4142022	D	Rv3698, (MTV025.046), len: 509 aa. Conserved hypothetical protein, highly similar to Q9AK89|SC10A9.15c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (505 aa), FASTA scores: opt: 1720, E(): 9e-103, (53.65% identity in 494 aa overlap). N-terminal end highly similar to CAC42136|SCBAC25F8.01 CONSERVED HYPOTHETICAL PROTEIN (FRAGMENT) from Streptomyces coelicolor (291 aa), FASTA scores: opt: 1078, E(): 8.7e-62, (52.6% identity in 291 aa overlap); and C-terminus highly similar to CAC44687|SCBAC17A6.42c (235 aa), FASTA scores: opt: 911, E(): 3.8e-51, (57.25% identity in 234 aa overlap). TBparse score is 0.934.; hypothetical protein	4140493..4142022	Mycobacterium tuberculosis H37Rv	885565
NP_218216.1	CDS	Rv3699	NC_000962.2	4142044	4142745	D	Rv3699, (MTV025.047), len: 233 aa. Conserved hypothetical protein, showing similarity with hypothetical proteins e.g. Q9P3V6|SPAC1348.04 (alias Q9P3E7|SPAC750.03c or Q9P7U5|SPAC977.03) from Schizosaccharomyces pombe (Fission yeast) (145 aa), FASTA scores: opt: 188, E(): 7.5e-05, (31.65% identity in 120 aa overlap); and Q9KB70|BH2058 from Bacillus halodurans (241 aa) FASTA scores: opt: 185, E(): 0.00018, (27.8% identity in 162 aa overlap); Q9XA90|SCF43A.25c PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (215 aa), FASTA scores: opt: 166, E(): 0.0025, (29.95% identity in 147 aa overlap); etc. Also highly similar to O06426|Rv0560c|MTCY25D10.39c HYPOTHETICAL 25.9 KDA PROTEIN from Mycobacterium tuberculosis (241 aa), FASTA scores: opt: 690, E(): 6.5e-36, (53.4% identity in 234 aa overlap); and similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. P71805|Rv1377c|MTCY02B12.11c (212 aa) FASTA scores: opt: 378, E(): 1.5e-16, (35.4% identity in 192 aa overlap); P71972|Rv2675c|MTCY441.44c (250 aa) FASTA scores: opt: 297, E(): 2e-11, (31.1% identity in 193 aa overlap); etc. TBparse score is 0.888.; hypothetical protein	4142044..4142745	Mycobacterium tuberculosis H37Rv	885779
NP_218217.1	CDS	Rv3700c	NC_000962.2	4142748	4143920	R	Rv3700c, (MTV025.048c), len: 390 aa. Conserved hypothetical protein; could be a transferase (EC 2.-.-.-) or a lyase (EC 4.-.-.-). Indeed, similar to various enzymes e.g. Q53824|CAC CAPREOMYCIN ACETYLTRANSFERASE from Streptomyces capreolus (359 aa), FASTA scores: opt: 338, E(): 1.1e-12, (33.35% identity in 363 aa overlap); Q9HXX3|CSD_PSEAE|PA3667 PROBABLE CYSTEINE DESULFURASE (EC 4.4.1.-) from Pseudomonas aeruginosa (401 aa) FASTA scores: opt: 260, E(): 4.8e-08, (30.2% identity in 404 aa overlap); Q9X815|SC6G10.30 PUTATIVE AMINOTRANSFERASE from Streptomyces coelicolor (460 aa), FASTA scores: opt: 243, E(): 5.4e-07, (29.15% identity in 374 aa overlap); Q9A761|CC1865 AMINOTRANSFERASE CLASS V from Caulobacter crescentus (379 aa), FASTA scores: opt: 234, E(): 1.6e-06, (27.95% identity in 383 aa overlap); O74351|NFS1_SCHPO|SPBC21D10.11c PROBABLE CYSTEINE DESULFURASE from Schizosaccharomyces pombe (Fission yeast) (498 aa), FASTA scores: opt: 232, E(): 2.5e-06, (29.1% identity in 285 aa overlap); Q9RME8|NIFS NIFS PROTEIN (CYSTEINE DESULFURASE, TRNA SPLICING PROTEIN) from Zymomonas mobilis (370 aa), FASTA scores: opt: 230, E(): 2.6e-06, (32.85% identity in 201 aa overlap); etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. TBparse score is 0.897.; hypothetical protein	complement(4142748..4143920)	Mycobacterium tuberculosis H37Rv	885161
NP_218218.1	CDS	Rv3701c	NC_000962.2	4143951	4144916	R	Rv3701c, (MTV025.049c), len: 321 aa. Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. Q9RCZ8|SCM1.46 from Streptomyces coelicolor (251 aa), FASTA scores: opt: 897, E(): 1.1e-50, (59.9% identity in 242 aa overlap); P73759|SLR0865 from Synechocystis sp. strain PCC 6803 (337 aa), FASTA scores: opt: 779, E(): 5.7e-43, (40.35% identity in 327 aa overlap); Q9GWA1|LM12.997 from Leishmania major (383 aa) FASTA scores: opt: 616, E(): 2.1e-32, (39.05% identity in 297 aa overlap); etc.; hypothetical protein	complement(4143951..4144916)	Mycobacterium tuberculosis H37Rv	885521
NP_218219.1	CDS	Rv3702c	NC_000962.2	4144913	4145614	R	Rv3702c, (MTV025.050c), len: 233 aa. Conserved hypothetical protein, highly similar to other hypothetical proteins Q9RCZ9|SCM1.45 from Streptomyces coelicolor (271 aa), FASTA scores: opt: 383, E(): 2.3e-17, (44.85% identity in 252 aa overlap); and P54004|Y199_SYNY3|SLR0199 from Synechocystis sp. strain PCC 6803 (304 aa), FASTA scores: opt: 292, E(): 1.7e-11, (30.05% identity in 263 aa overlap); and similar to others e.g. Q9KMU4|VCA0225 from Vibrio cholerae (254 aa), FASTA scores: opt: 260, E(): 1.6e-09, (29.8% identity in 245 aa overlap). Equivalent to AAK48172 from Mycobacterium tuberculosis strain CDC1551 (194 aa) but longer 39 aa. TBparse score is 0.913.; hypothetical protein	complement(4144913..4145614)	Mycobacterium tuberculosis H37Rv	885224
NP_218220.1	CDS	Rv3703c	NC_000962.2	4145614	4146891	R	Rv3703c, (MTV025.051c), len: 425 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. Q9RD00|SCM1.44 from Streptomyces coelicolor (446 aa), FASTA scores: opt: 1480, E(): 1.4e-85, (53.9% identity in 421 aa overlap); P72841|SLR1303 from Synechocystis sp. strain PCC 6803 (410 aa), FASTA scores: opt: 533, E(): 4.5e-26, (36.6% identity in 429 aa overlap); Q9KYH7|SCC61A.16 from Streptomyces coelicolor (256 aa), FASTA scores: opt: 266, E(): 1.9e-09, (32.25% identity in 248 aa overlap); etc. Also similar to P95060|Rv0712|MTCY210.31 HYPOTHETICAL 32.7 KDA PROTEIN from Mycobacterium tuberculosis (299 aa), FASTA scores: opt: 243, E(): 5.9e-08, (30.6% identity in 304 aa overlap). TBparse score is 0.908.; hypothetical protein	complement(4145614..4146891)	Mycobacterium tuberculosis H37Rv	885128
NP_218221.1	CDS	gshA	NC_000962.2	4146888	4148186	R	Rv3704c, (MTV025.052c), len: 432 aa. Possible gshA, glutamate--cysteine ligase (EC 6.3.2.2), similar to many e.g. Q9A2Z2|CC3414 GLUTAMATE--CYSTEINE LIGASE from Caulobacter crescentus (453 aa), FASTA scores: opt: 404, E(): 5.9e-17, (30.45% identity in 312 aa overlap); Q9SEH0|GSH1 GAMMA-GLUTAMYLCYSTEINYL SYNTHETASE PRECURSOR from Pisum sativum (Garden pea) (499 aa), FASTA scores: opt: 400, E(): 1.1e-16, (26.4% identity in 439 aa overlap); Q9RH09|GSH GAMMA-GLUTAMYLCYSTEINE SYNTHETASE from Zymomonas mobilis (462 aa), FASTA scores: opt: 397, E(): 1.6e-16, (28.95% identity in 304 aa overlap); P46309|GSH1_ARATH|GSH1|AT4G23100|F7H19.290 GLUTAMATE--CYSTEINE LIGASE from Arabidopsis thaliana (Mouse-ear cress) (522 aa), FASTA scores: opt: 395, E(): 2.3e-16, (27.25% identity in 385 aa overlap); etc. But note that this putative protein is also similar to Q9JMV4|GSHA PUTATIVE GLUTATHIONE SYNTHETASE (FRAGMENT) from Bradyrhizobium japonicum (460 aa), FASTA scores: opt: 498, E(): 1.3e-22, (33.35% identity in 333 aa overlap) (no significant publications found (August 2001)). TBparse score is 0.898.; glutamate--cysteine ligase gshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase)	complement(4146888..4148186)	Mycobacterium tuberculosis H37Rv	885053
NP_218222.1	CDS	Rv3705c	NC_000962.2	4148318	4148962	R	Rv3705c, (MTV025.053c), len: 214 aa. Conserved hypothetical protein, equivalent to Q9CB80|ML2320 HYPOTHETICAL PROTEIN from Mycobacterium leprae (215 aa) FASTA scores: opt: 1145, E(): 5.9e-68, (79.45% identity in 214 aa overlap). Some similarity to the C-terminal end of Q11053|PKNH_MYCTU|Rv1266c|MT1304|MTCY50.16 PROBABLE SERINE/THREONINE-PROTEIN from Mycobacterium tuberculosis (626 aa), FASTA scores: opt: 175, E(): 0.0005, (24.9% identity in 201 aa overlap); and to the N-terminal end of P23903|E13B_BACCI|GLCA GLUCAN ENDO-1,3-BETA-GLUCOSIDASE A1 PRECURSOR from Bacillus circulans (682 aa), FASTA scores: opt: 122, E(): 1.6, (25.6% identity in 164 aa overlap). TBparse score is 0.909.; hypothetical protein	complement(4148318..4148962)	Mycobacterium tuberculosis H37Rv	885229
YP_178006.1	CDS	Rv3705A	NC_000962.2	4149091	4149480	R	Rv3705A, len: 129 aa. Conserved hypothetical protein, similar to downstream ORF O69674|Rv3706c|MTV025.054c CONSERVED HYPOTHETICAL PROLINE RICH PROTEIN from Mycobacterium tuberculosis (106 aa), FASTA scores: opt: 245, E(): 0.00013, (40.7% identity in 113 aa overlap).; proline rich protein	complement(4149091..4149480)	Mycobacterium tuberculosis H37Rv	3205111
NP_218223.1	CDS	Rv3706c	NC_000962.2	4149591	4149911	R	Rv3706c, (MTV025.054c), len: 106 aa. Conserved ypothetical pro-rich protein, similar to upstream ORF Rv3705A (129 aa), and AAK48176|MT3808.1 HYPOTHETICAL 13.0 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (129 aa), FASTA scores: opt: 245, E(): 4.4e-06, (40.7% identity in 113 aa overlap).; proline rich protein	complement(4149591..4149911)	Mycobacterium tuberculosis H37Rv	885222
NP_218224.1	CDS	Rv3707c	NC_000962.2	4150030	4151040	R	Rv3707c, (MTV025.055c), len: 336 aa. Equivalent to Q9CB79|ML2321 HYPOTHETICAL PROTEIN from Mycobacterium leprae (336 aa), FASTA scores: opt: 1948, E(): 6.7e-110, (81.95% identity in 332 aa overlap); and P41402|YASD_MYCSM HYPOTHETICAL 35.9 KDA PROTEIN IN THE ASPARTOKINASE GENE CLUSTER from Mycobacterium smegmatis (333 aa), FASTA scores: opt: 1731, E(): 7.4e-97, (70.85% identity in 333 aa overlap).; hypothetical protein	complement(4150030..4151040)	Mycobacterium tuberculosis H37Rv	885587
NP_218225.1	CDS	asd	NC_000962.2	4151180	4152217	R	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase	complement(4151180..4152217)	Mycobacterium tuberculosis H37Rv	885118
NP_218226.1	CDS	ask	NC_000962.2	4152218	4153483	R	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase	complement(4152218..4153483)	Mycobacterium tuberculosis H37Rv	885223
NP_218227.2	CDS	leuA	NC_000962.2	4153860	4155674	D	Rv3710, (MTV025.058), len: 644 aa. leuA, alpha-isopropylmalate synthase (EC 4.1.3.12) (see citations below), equivalent to Q9CB76|LEUA|ML2324 2-ISOPROPYLMALATE SYNTHASE from Mycobacterium leprae (607 aa), FASTA scores: opt: 3291, E(): 3.7e-192, (80.7% identity in 642 aa overlap). Also highly similar to many e.g. P42455|LEU1_CORGL|LEUA from Corynebacterium glutamicum (Brevibacterium flavum) (616 aa), FASTA scores: opt: 2547, E(): 5.3e-147, (63.25% identity in 645 aa overlap); O31046|LEU1_STRCO|LEUA from Streptomyces coelicolor (573 aa), FASTA scores: opt: 2226, E(): 1.5e-127, (57.8% identity in 616 aa overlap); BAB49833|Q98HN3|MLR2792 from Rhizobium loti (Mesorhizobium loti) (588 aa), FASTA scores: opt: 1849, E(): 1.1e-104, (58.0% identity in 536 aa overlap); etc. Equivalent to AAK48181 from Mycobacterium tuberculosis strain CDC1551 (659 aa) but shorter 15 aa. Contains PS00815 and PS00816 Alpha-isopropylmalate and homocitrate synthases signatures 1 and 2. BELONGS TO THE ALPHA-IPM SYNTHETASE / HOMOCITRATE SYNTHASE FAMILY.; 2-isopropylmalate synthase	4153860..4155674	Mycobacterium tuberculosis H37Rv	885092
NP_218228.1	CDS	dnaQ	NC_000962.2	4155740	4156729	R	3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon	complement(4155740..4156729)	Mycobacterium tuberculosis H37Rv	885088
NP_218229.1	CDS	Rv3712	NC_000962.2	4156981	4158222	D	Rv3712, (MTV025.060), len: 413 aa. Possible ligase (EC 6.-.-.-), equivalent to O69522|ML2326|MLCB2407.24c HYPOTHETICAL 43.8 KDA PROTEIN (POSSIBLE LIGASE) from Mycobacterium leprae (411 aa), FASTA scores: opt: 2265, E(): 8e-129, (84.25% identity in 413 aa overlap). Also similar to ligases or hypothetical proteins e.g. Q9FCA1|2SCG58.12 PUTATIVE LIGASE from Streptomyces coelicolor (412 aa), FASTA scores: opt: 1168, E(): 6.7e-63, (45.8% identity in 406 aa overlap); P74303|SLR0938 HYPOTHETICAL 50.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (459 aa), FASTA scores: opt: 392, E(): 3.1e-16, (28.45% identity in 397 aa overlap); Q99ZX1|SPY1035 PUTATIVE UDP-N-ACETYLMURAMYL TRIPEPTIDE SYNTHETASE (EC 6.3.2.13) from Streptococcus pyogenes (445 aa), FASTA scores: opt: 335, E(): 8.1e-13, (29.2% identity in 438 aa overlap); Q9CGJ0|YLBD HYPOTHETICAL PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (449 aa), FASTA scores: opt: 324, E(): 3.8e-12, (28.75% identity in 445 aa overlap); Q9ZGG7|MURC UDP-N-ACETYLMURAMYL TRIPEPTIDE SYNTHETASE from Heliobacillus mobilis (455 aa), FASTA scores: opt: 292, E(): 3.2e-10, (30.75% identity in 449 aa overlap); etc. TBparse score is 0.874.; ligase	4156981..4158222	Mycobacterium tuberculosis H37Rv	885228
NP_218230.1	CDS	cobQ2	NC_000962.2	4158227	4158922	D	Rv3713, (MTV025.061), len: 231 aa. Possible cobQ2, cobyric acid synthase (EC undetermined), equivalent to O69521|ML2327|MLCB2407.23c HYPOTHETICAL 24.5 KDA PROTEIN from Mycobacterium leprae (230 aa), FASTA scores: opt: 1313, E(): 4.7e-73, (86.1% identity in 230 aa overlap). Also partially similar to several cobyric acid synthases and hypothetical proteins e.g. Q9FCA0|2SCG58.13 HYPOTHETICAL 26.2 KDA PROTEIN from Streptomyces coelicolor (242 aa), FASTA scores: opt: 639, E(): 6.2e-32, (46.6% identity in 234 aa overlap); Q9ZGG8|COBQ COBYRIC ACID SYNTHASE from Heliobacillus mobilis (252 aa), FASTA scores: opt: 501, E(): 1.7e-23, (40.75% identity in 206 aa overlap); BAB58053|SAV1891 HYPOTHETICAL 27.4 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (243 aa), FASTA scores: opt: 400, E(): 2.3e-17, (35.95% identity in 217 aa overlap); Q9CGJ1|COBQ COBYRIC ACID SYNTHASE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (261 aa), FASTA scores: opt: 353, E(): 1.8e-14, (35.3% identity in 201 aa overlap); O26880|COBQ_METTH|MTH787 PROBABLE COBYRIC ACID SYNTHASE from Methanobacterium thermoautotrophicum (504 aa), FASTA scores: opt: 201, E(): 5.6e-05, (33.35% identity in 171 aa overlap); etc. Also similar to hypothetical mycobacterial proteins O05811|COBB_MYCTU|Rv2848c|MT2914|MTCY24A1.09 (457 aa) and P71842|Rv0789c|MTCY369.33c (199 aa). SEEMS TO BELONG TO THE COBB/COBQ FAMILY, COBQ SUBFAMILY.; cobyric acid synthase CobQ2	4158227..4158922	Mycobacterium tuberculosis H37Rv	885584
NP_218231.1	CDS	Rv3714c	NC_000962.2	4158931	4159821	R	Rv3714c, (MTV025.062c), len: 296 aa. Conserved hypothetical protein, highly similar to O07396|MAV346 MAV346 PROTEIN from Mycobacterium avium (346 aa) FASTA scores: opt: 834, E(): 2.2e-46, (50.0% identity in 286 aa overlap); and also highly similar to several proteins from Mycobacterium tuberculosis e.g. O53421|Rv1073|MTV017.26 (283 aa), FASTA scores: opt: 869, E(): 1e-48, (51.1% identity in 270 aa overlap); P71763|Rv1482c|MTCY277.03c (339 aa), FASTA scores: opt: 775, E(): 1.3e-42, (46.35% identity in 289 aa overlap); P96837|Rv3555c|MTCY06G11.02c (289 aa), FASTA scores: opt: 733, E(): 5.9e-40, (44.15% identity in 281 aa overlap); etc. Partially similar to Q9Z512|UVRC_STRCO|SCC54.13c EXCINUCLEASE ABC SUBUNIT C from Streptomyces coelicolor (728 aa), FASTA scores: opt: 122, E(): 2.5, (27.0% identity in 174 aa overlap). Equivalent to AAK48186 from Mycobacterium tuberculosis strain CDC1551 (341 aa) but shorter 45 aa.; hypothetical protein	complement(4158931..4159821)	Mycobacterium tuberculosis H37Rv	885456
NP_218232.1	CDS	recR	NC_000962.2	4159889	4160500	R	involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR	complement(4159889..4160500)	Mycobacterium tuberculosis H37Rv	885307
NP_218233.1	CDS	Rv3716c	NC_000962.2	4160512	4160913	R	Rv3716c, (MTV025.064c), len: 133 aa. Conserved hypothetical protein, equivalent to O69519|Y1B6_MYCLE|ML2330|MLCB2407.20 HYPOTHETICAL 11.9 KDA PROTEIN from Mycobacterium leprae (116 aa), FASTA scores: opt: 616, E(): 2.6e-21, (84.55% identity in 110 aa overlap). Also highly similar to hypothetical 12 kDa proteins in the vicinity of recR from other bacteria e.g. Q9XAI3|YT3D_STRCO|SC66T3.30c HYPOTHETICAL 11.7 KDA PROTEIN from Streptomyces coelicolor (115 aa), FASTA scores: opt: 379, E(): 9.5e-11, (50.8% identity in 122 aa overlap); BAB56641|SAV0479 CONSERVED HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (105 aa) FASTA scores: opt: 295, E(): 4.9e-07, (41.75% identity in 103 aa overlap); Q99WC4P24281|YAAK_BACSU HYPOTHETICAL 11.8 KDA PROTEIN IN DNAZ-RECR INTERGENIC REGION from Bacillus subtilis (107 aa), FASTA scores: opt: 272, E(): 5.3e-06, (39.4% identity in 104 aa overlap); P17577|YBAB_ECOLI|B0471|Z0588|ECS0524 from Escherichia coli strain K and O157:H7 (109 aa), FASTA scores: opt: 256, E(): 2.8e-05, (38.0% identity in 100 aa overlap); etc. Contains probable coiled-coil domain from aa 1-40. SEEMS TO BELONG TO THE UPF0133 FAMILY. TBparse score is 0.888.; hypothetical protein	complement(4160512..4160913)	Mycobacterium tuberculosis H37Rv	885595
NP_218234.1	CDS	Rv3717	NC_000962.2	4161048	4161773	D	Rv3717, (MTV025.065), len: 241 aa. Conserved hypothetical protein, equivalent to O69518|MLCB2407.19c (alias Q9CB75|ML2331 256 aa) HYPOTHETICAL 25.1 KDA PROTEIN from Mycobacterium leprae (244 aa), FASTA scores: opt: 1325, E(): 5.7e-74, (81.95% identity in 244 aa overlap). Also similar to Q9KXK7|SCC53.04 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (336 aa), FASTA scores: opt: 536, E(): 1.2e-25, (41.2% identity in 233 aa overlap); and shows similarity with C-terminal end of other proteins e.g. Q9RMZ0|PXO2-42 PXO2-42 PROTEIN from Bacillus anthracis (531 aa), FASTA scores: opt: 191, E(): 0.00022, (26.6% identity in 222 aa overlap); Q9RTX0 PUTATIVE N-ACETYLMURAMOYL-L-ALANINE AMIDASE (603 aa); Q9LCR4|CWLU CWLU PROTEIN from Paenibacillus polymyxa (Bacillus polymyxa) (524 aa), FASTA scores: opt: 141, E(): 0.24, (29.2% identity in 219 aa overlap); etc. Shows similarity with C-terminal end of O53593|CWLM|Rv3915|MTV028.06 PUTATIVE HYDROLASE from Mycobacterium tuberculosis (406 aa), FASTA scores: opt: 176, E(): 0.0014, (25.7% identity in 218 aa overlap). TBparse score is 0.894.; hypothetical protein	4161048..4161773	Mycobacterium tuberculosis H37Rv	885602
NP_218235.1	CDS	Rv3718c	NC_000962.2	4161815	4162258	R	Rv3718c, (MTV025.066c), len: 147 aa. Conserved hypothetical protein, equivalent to O69517|ML2332|MLCB2407.18 HYPOTHETICAL 15.5 KDA PROTEIN from Mycobacterium leprae (145 aa), FASTA scores: opt: 780, E(): 1.4e-44, (81.95% identity in 144 aa overlap). Also highly similar to Q9ZBJ2|SC9C7.18 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (147 aa) FASTA scores: opt: 475, E(): 1.7e-24, (52.05% identity in 146 aa overlap); and showing some similarity to various proteins e.g. P27538|PR2_PETCR PATHOGENESIS-RELATED PROTEIN 2 from Petroselinum crispum (Parsley) (Petroselinum hortense) (158 aa); P92918|ALL2_APIGR MAJOR ALLERGEN API G 2 from Apium graveolens (Celery) (159 aa); etc. TBparse score is 0.891. Thought to be differentially expressed within host cells (see citation below).; hypothetical protein	complement(4161815..4162258)	Mycobacterium tuberculosis H37Rv	885582
NP_218236.1	CDS	Rv3719	NC_000962.2	4162306	4163718	D	Rv3719, (MTV025.067), len: 470 aa. Conserved hypothetical protein, equivalent to O69516|ML2333|MLCB2407.17c HYPOTHETICAL 51.8 KDA PROTEIN from Mycobacterium leprae (459 aa), FASTA scores: opt: 2593, E(): 7.8e-161, (82.75% identity in 458 aa overlap). Also some similarity to Q9CU63|5830417J06RIK HYPOTHETICAL PROTEIN (FRAGMENT) from Mus musculus (Mouse) (479 aa) FASTA scores: opt: 454, E(): 6.1e-22, (27.1% identity in 413 aa overlap); Q9HBA8 SELADIN-1 (UNKNOWN) from Homo sapiens (Human) (516 aa), FASTA scores: opt: 444, E(): 2.9e-21, (26.7% identity in 412 aa overlap); O17397|DIMH_CAEEL|F52H2.6 DIMINUTO-LIKE PROTEIN from Caenorhabditis elegans (525 aa), FASTA scores: opt: 419, E(): 1.2e-19, (24.4% identity in 434 aa overlap); Q39085|DIM_ARATH|DWF1 CELL ELONGATION PROTEIN DIMINUTO from Arabidopsis thaliana (Mouse-ear cress) (561 aa) FASTA scores: opt: 318, E(): 4.8e-13, (24.6% identity in 455 aa overlap); etc. Also some similarity to Mycobacterium tuberculosis hypothetical proteins P72056|Rv3790|MTCY13D12.24 (461 aa) FASTA scores: opt: 174, E(): 0.00016; (25.1% identity in 426 aa overlap); and Q50685|Rv2280|MTCY339_30c (459 aa). TBparse score is 0.936.; hypothetical protein	4162306..4163718	Mycobacterium tuberculosis H37Rv	885855
NP_218237.1	CDS	Rv3720	NC_000962.2	4163736	4164998	D	Rv3720, (MTV025.068), len: 420 aa. Possible fatty-acyl-phospholipid synthase (EC 2.1.1.-), equivalent to Q9CB74|ML2334 (alias O69515|MLCB2407.16c, 439 aa) HYPOTHETICAL PROTEIN from Mycobacterium leprae (420 aa) FASTA scores: opt: 2508, E(): 4.7e-153, (86.45% identity in 420 aa overlap). Also similar (especially at the C-terminus) to various fatty-acid synthases (principally cyclopropane-fatty-acyl-phospholipid synthases (EC 2.1.1.79)) and hypothetical proteins e.g. Q9KZ58|SCE25.32c PUTATIVE FATTY ACID SYNTHASE from Streptomyces coelicolor (438 aa), FASTA scores: opt: 1101, E(): 5.5e-63, (46.1% identity in 425 aa overlap); P31049|YLP3_PSEPU HYPOTHETICAL 44.7 KDA PROTEIN from Pseudomonas putida (394 aa), FASTA scores: opt: 810, E(): 2.1e-44, (46.4% identity in 293 aa overlap); Q9HT28|PA5546 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (394 aa), FASTA scores: opt: 804, E(): 5.2e-44, (40.7% identity in 371 aa overlap); Q9RSD7|DR2187 PUTATIVE CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Deinococcus radiodurans (462 aa), FASTA scores: opt: 747, E(): 2.6e-40, (35.95% identity in 409 aa overlap); BAB50831|Q98ET6|MLL4091 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Rhizobium loti (Mesorhizobium loti) (422 aa), FASTA scores: opt: 674, E(): 1.1e-35, (39.1% identity in 284 aa overlap); P30010|CFA_ECOLI|CDFA|B1661 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIP SYNTHASE from Escherichia coli strain K12 (381 aa), FASTA scores: opt: 530, E(): 1.7e-26, (33.65% identity in 312 aa overlap); etc. Also similar to other proteins from Mycobacterium tuberculosis e.g. CMA2|Rv0503c|MTCY20G9.30c (302 aa); P96911|Rv0621|MTCY20H10 (354 aa); O50416|LPQD|Rv3390|MTV004.48 (236 aa); etc.; fatty acid synthase	4163736..4164998	Mycobacterium tuberculosis H37Rv	885219
NP_218238.1	CDS	dnaZX	NC_000962.2	4164995	4166731	R	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau	complement(4164995..4166731)	Mycobacterium tuberculosis H37Rv	885361
NP_218239.2	CDS	Rv3722c	NC_000962.2	4166821	4168128	R	Rv3722c, (MTV025.070c), len: 435 aa. Conserved hypothetical protein, equivalent to O69513|MLCB2407.14 (alias Q9CB73|ML2336, 463 aa) HYPOTHETICAL 46.8 KDA PROTEIN from Mycobacterium leprae (426 aa), FASTA scores: opt: 2505, E(): 8.3e-154, (87.25% identity in 424 aa overlap). Also highly similar to Q9RU17|DR1579 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (452 aa), FASTA scores: opt: 1162, E(): 3.1e-67, (44.8% identity in 422 aa overlap); and partially similar to Q9I371|PA1654 PROBABLE AMINOTRANSFERASE from Pseudomonas aeruginosa (388 aa) FASTA scores: opt: 162, E(): 0.0078, (25.85% identity in 348 aa overlap) and other aminotransferases. TBparse score is 0.900. N-terminus extended since first submission (previously 408 aa).; hypothetical protein	complement(4166821..4168128)	Mycobacterium tuberculosis H37Rv	885321
NP_218240.1	CDS	Rv3723	NC_000962.2	4168536	4169300	D	Rv3723, (MTV025.071), len: 254 aa. Probable conserved transmembrane protein, with hydrophobic stretches at the N-terminus, and equivalent to O69512|ML2337|MLCB2407.13c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (250 aa), FASTA scores: opt: 1029, E(): 1.2e-44, (64.45% identity in 253 aa overlap). TBparse score is 0.900.; transmembrane protein	4168536..4169300	Mycobacterium tuberculosis H37Rv	885791
YP_178007.1	CDS	cut5a	NC_000962.2	4169467	4169709	D	Rv3724A, (MTV025.072), len: 80 aa. Probable cut5a, truncated cutinase precursor (EC 3.1.1.-), similar to N-terminal end of others e.g. Q9KK87 SERINE ESTERASE CUTINASE from Mycobacterium avium (220 aa), FASTA scores: opt: 202, E(): 1.5e-06, (56.45% identity in 62 aa overlap); Q9XB09|RVD2-RV1758 PROTEIN (FRAGMENT) from Mycobacterium bovis BCG (143 aa), FASTA scores: opt: 200, E(): 1.5e-06, (61.4% identity in 57 aa overlap); and Q00298|CUTI_BOTCI|CUTA CUTINASE PRECURSOR from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 108, E(): 2.2, (40.4% identity in 52 aa overlap). Also highly similar to others from Mycobacterium tuberculosis e.g. O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 189, E(): 1.2e-05, (58.0% identity in 50 aa overlap); Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c PROBABLE CUTINASE PRECURSOR (219 aa), FASTA scores: opt: 172, E(): 0.00015, (59.2% identity in 49 aa overlap); O06793|Rv1758|MTCY28.24|Z95890 HYPOTHETICAL 17.9 KDA PROTEIN (174 aa), FASTA scores: opt: 641, E(): 2.7e-29, (57.2% identity in 166 aa overlap); O06319|Rv3452|MTY13E12.05; and U00015_11 from Mycobaterium leprae. BELONGS TO THE CUTINASE FAMILY. Rest of cutinase ORF continues as Rv3724B|CUT5B, frameshifting could occur near position 4169668. Sequence has been checked but no errors found.; cutinase precursor	4169467..4169709	Mycobacterium tuberculosis H37Rv	3205112
YP_178008.1	CDS	cut5b	NC_000962.2	4169606	4170169	D	Rv3724B, (MTV025.072), len: 187 aa. Probable cut5b, truncated cutinase (EC 3.1.1.-), similar to C-terminal end of others e.g. Q9XB09|RVD2-RV1758 PROTEIN (FRAGMENT) from Mycobacterium bovis BCG (143 aa) FASTA scores: opt: 335, E(): 3.4e-12, (53.25% identity in 92 aa overlap); Q9KK87 SERINE ESTERASE CUTINASE from Mycobacterium avium (220 aa), FASTA scores: opt: 251, E(): 2.5e-07, (44.05% identity in 168 aa overlap). Also similar to proteins from Mycobacterium tuberculosis e.g. O06793|Rv1758|MTCY28.24 HYPOTHETICAL 17.9 KDA PROTEIN (174 aa), FASTA scores: opt: 641, E(): 2.5e-29, (57.25% identity in 166 aa overlap); O06319|Rv3452|MTCY13E12.05 HYPOTHETICAL 23.1 KDA PROTEIN (226 aa), FASTA scores: opt: 385, E(): 7.5e-15, (46.65% identity in 165 aa overlap); O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 PROBABLE CUTINASE PRECURSOR (247 aa), FASTA scores: opt: 307, E(): 1.9e-10, (40.7% identity in 167 aa overlap); Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 PROBABLE CUTINASE PRECURSOR (217 aa), FASTA scores: opt: 261, E(): 6.7e-08, (50.9% identity in 169 aa overlap); etc; and U00015_11 from Mycobacterium lepra. 5'-end of gene is Rv3724A|CUT5A; frameshifting may occur near position 4169668. TBparse score is 0.918.; cutinase	4169606..4170169	Mycobacterium tuberculosis H37Rv	885390
NP_218242.1	CDS	Rv3725	NC_000962.2	4170214	4171143	D	Rv3725, (MTV025.073), len: 309 aa. Possible reductase (EC 1.-.-.-), similar to various oxidoreductases and hypothetical proteins e.g. O34285|HPNA HPNA PROTEIN from Zymomonas mobilis (337 aa), FASTA scores: opt: 317, E(): 6.1e-11, (30.5% identity in 272 aa overlap); Q9SZB3|F17M5.120|AT4G33360|AAK49584 HYPOTHETICAL 37.9 KDA PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (344 aa), FASTA scores: opt: 314, E(): 9.1e-11, (30.35% identity in 267 aa overlap); AAK59445|AT4G33360 PUTATIVE DIHYDROKAEMPFEROL 4-REDUCTASE from Arabidopsis thaliana (Mouse-ear cress) (332 aa), FASTA scores: opt: 313, E(): 1e-10, (30.8% identity in 263 aa overlap); Q9FSC6|CCR CINNAMOYL-CoA REDUCTASE (EC 1.2.1.44) from Populus trichocarpa (Western balsam poplar) (338 aa), FASTA scores: opt: 305, E(): 2.9e-10, (30.3% identity in 274 aa overlap); Q9M631 CINNAMOYL CoA REDUCTASE from Populus tremuloides (Quaking aspen) (337 aa), FASTA scores: opt: 291, E(): 1.8e-09, (30.15% identity in 272 aa overlap); P73212|DFRA_SYNY3|LR1706 PUTATIVE DIHYDROFLAVONOL-4-REDUCTASE (EC 1.1.1.219) (DIHYDROKAEMPFEROL 4-REDUCTASE) from Synechocystis sp. strain PCC 6803 (343 aa), FASTA scores: opt: 278, E(): 1e-08, (29.35% identity in 259 aa overlap); etc. Also some similarity to proteins from Mycobacterium tuberculosis e.g. P96816|Rv0139|MTCI5.13 HYPOTHETICAL PROTEIN (340 aa) FASTA scores: opt: 234, E(): 3.2e-06, (28.25% identity in 269 aa overlap); and O06373|galE1|Rv3634c|MTCY15C10.18 PROBABLE UDP-GLUCOSE 4-EPIMERASE (314 aa) (27.3% identity in 194 aa overlap). TBparse score is 0.960.; oxidoreductase	4170214..4171143	Mycobacterium tuberculosis H37Rv	885887
NP_218243.1	CDS	Rv3726	NC_000962.2	4171421	4172614	D	Rv3726, (MTV025.074), len: 397 aa. Possible dehydrogenase (EC 1.-.-.-), similar to many e.g. O34788|YDJL DEHYDROGENASE from Bacillus subtilis (346 aa) FASTA scores: opt: 401, E(): 3.4e-17, (29.6% identity in 395 aa overlap); Q59696|ADH 2,3-BUTANEDIOL DEHYDROGENASE (EC 1.1.1.4) from seudomonas putida (362 aa), FASTA scores: opt: 326, E(): 1.3e-12, (29.45% identity in 387 aa overlap); AAG59541|YJJN PUTATIVE OXIDOREDUCTASE from Escherichia coli strain EDL933 (345 aa), FASTA scores: opt: 325, E(): 1.5e-12, (30.85% identity in 256 aa overlap); Q9HWM8|PA4153 2,3-BUTANEDIOL DEHYDROGENASE from Pseudomonas aeruginosa (363 aa), FASTA scores: opt: 324, E(): 1.8e-12, (30.5% identity in 387 aa overlap); etc. TBparse score is 0.922.; dehydrogenase	4171421..4172614	Mycobacterium tuberculosis H37Rv	885801
NP_218244.1	CDS	Rv3727	NC_000962.2	4172955	4174763	D	Rv3727, (MTV025.075), len: 602 aa. Possible oxidoreductase (EC 1.-.-.-), similar to several plants phytoene dehydrogenases/desaturases (EC 1.3.-.-) e.g. Q9HSE1|CRTI3|VNG0277G PHYTOENE DEHYDROGENASE from Halobacterium sp. strain NRC-1 (541 aa), FASTA scores: opt: 299, E(): 1.1e-10, (29.85% identity in 576 aa overlap); Q9FZL6|CITPDS1 PHYTOENE DESATURASE from Citrus unshiu (Satsuma orange) (553 aa), FASTA scores: opt: 164, E(): 0.018, (24.2% identity in 434 aa overlap); Q07356|CRTI_ARATH|PDS|AT4G14210|DL3145c PHYTOENE DEHYDROGENASE PRECURSOR from Arabidopsis thaliana (Mouse-ear cress) (566 aa), FASTA scores: opt: 163, E(): 0.021, (23.95% identity in 434 aa overlap); etc. N-terminal end similar to O69871|SC1C3.29 PUTATIVE PROTOPORPHYRINOGEN OXIDASE (FRAGMENT) from Streptomyces coelicolor (61 aa), FASTA scores: opt: 154, E(): 0.012, (60.45% identity in 43 aa overlap). The region between aa 155-310 is highly similar to Q49778|B2126_C1_169 from Mycobacterium leprae (159 aa), FASTA scores: opt: 437, E(): 1.5e-19, (46.6% identity in 161 aa overlap). And the region between aa 462-546 is highly similar to the N-terminal end of Q50003|U1764T from Mycobacterium leprae (155 aa), FASTA scores: opt: 277, E(): 8.3e-10, (57.65% identity in 85 aa overlap). TBparse score is 0.965.; oxidoreductase	4172955..4174763	Mycobacterium tuberculosis H37Rv	885766
NP_218245.1	CDS	Rv3728	NC_000962.2	4174873	4178070	D	Rv3728, (MTV025.076), len: 1065 aa. Probable conserved transmembrane protein organised into two domains. Domain comprising the first 510 aa residues is similar to various multidrug resistance and efflux proteins and contains sugar transport protein signature 1 (PS00216). Domain corresponding to the last 550 aa residues contains cyclic nucleotide-binding domain signature 2 (PS00889) and is very similar to Q50733|YP65_MYCTU|Rv2565|MT2641|MTCY9C4.03c hypothetical 62.1 kDa protein from Mycobacterium tuberculosis (31.0% identity in 546 aa overlap). Highly similar to O05884|Rv3239c|MTCY20B11.14c PROBABLE TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis (1048 aa) FASTA scores: opt: 4328, E(): 5e-201, (64.15% identity in 1046 aa overlap). N-terminal end similar to P71879|Rv2333c|MTCY3G12.01|MTCY98.02c (537 aa); P71836|Rv0783c|MTCY369.27c (540 aa); and O07753|Rv1877|MTCY180.41c (687 aa). SEEMS BELONG TO THE SUGAR TRANSPORTER FAMILY. Possibly member of major facilitator superfamily (MFS).; hypothetical protein	4174873..4178070	Mycobacterium tuberculosis H37Rv	885271
NP_218246.1	CDS	Rv3729	NC_000962.2	4178285	4180615	D	Rv3729, (MTV025.077), len: 776 aa. Conserved hypothetical protein, possible transferase (EC 2.-.-.-), similar to several hypothetical proteins and various transferases e.g. O26919|MTH831 MOLYBDENUM COFACTOR BIOSYNTHESIS MOAA HOMOLOG from Methanobacterium thermoautotrophicum (497 aa), FASTA scores: opt: 697, E(): 4.8e-34, (30.7% identity in 492 aa overlap); Q58036|Y619_METJA|MJ0619 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (506 aa), FASTA scores: opt: 670, E(): 2e-32, (30.6% identity in 497 aa overlap); O27968|AF2316 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (518 aa), FASTA scores: opt: 477, E(): 6.4e-21, (29.4% identity in 500 aa overlap); BAB60102|TVG0985801 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Thermoplasma volcanium (606 aa), FASTA scores: opt: 402, E(): 2.1e-16, (28.1% identity in 509 aa overlap); etc. C-terminus similar to methyltransferases e.g. Q9S0N6|AVED C5-O-METHYLTRANSFERASE from Streptomyces avermitilis (283 aa), FASTA scores: opt: 298, E(): 1.9e-10, (31.5% identity in 292 aa overlap). Also similar to the Mycobacterium tuberculosis proteins P71673|YE05_MYCTU|Rv1405c|MT1449|MTCY21B4.22c (274 aa); and Q50584|Rv1523|MTCY19G5.05c. TBparse score is 0.909.; transferase	4178285..4180615	Mycobacterium tuberculosis H37Rv	885706
NP_218247.1	CDS	Rv3730c	NC_000962.2	4180680	4181720	R	Rv3730c, (MTV025.078c), len: 346 aa. Conserved hypothetical protein, highly similar to Q9XAM1|SC4C6.19 HYPOTHETICAL 38.5 KDA PROTEIN from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1313, E(): 2.2e-75, (59.25% identity in 336 aa overlap); and similar to C-terminal end of PUTATIVE ATP-DEPENDENT DNA LIGASES e.g. BAB49297|MLL2077 from Rhizobium loti (Mesorhizobium loti) (833 aa), FASTA scores: opt: 550, E(): 5.3e-27, (31.3% identity in 294 aa overlap); and BAB54816|MLL9625 from Rhizobium loti (Mesorhizobium loti) plasmid pMLb (883 aa) FASTA scores: opt: 492, E(): 2.5e-23, (33.7% identity in 291 aa overlap); etc. Also similar to the hypothetical proteins e.g. Q9ZC15|SC1E6.07 HYPOTHETICAL 34.9 KDA PROTEIN from Streptomyces coelicolor (319 aa) FASTA scores: opt: 537, E(): 1.5e-26, (34.95% identity in 292 aa overlap); Q9XAF7|SC6G9.25 HYPOTHETICAL 32.1 KDA PROTEIN from Streptomyces coelicolor (293 aa), FASTA scores: opt: 474, E(): 1.3e-22, (33.75% identity in 302 aa overlap); etc. Also highly similar to P95226|Rv0269c|MTCY06A4.13c HYPOTHETICAL 44.0 KDA PROTEIN from Mycobacterium tuberculosis (397 aa), FASTA scores: opt: 940, E(): 7.7e-52, (50.3% identity in 312 aa overlap). TBparse score is 0.895.; hypothetical protein	complement(4180680..4181720)	Mycobacterium tuberculosis H37Rv	885201
NP_218248.1	CDS	ligC	NC_000962.2	4181758	4182834	D	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; ATP-dependent DNA ligase	4181758..4182834	Mycobacterium tuberculosis H37Rv	885771
NP_218249.1	CDS	Rv3732	NC_000962.2	4182934	4183992	D	Rv3732, (MTV025.080), len: 352 aa. Conserved hypothetical protein. The region between aa 175-352 is highly similar to the region between aa 72-257 of Q9KH39 HYPOTHETICAL 55.5 KDA PROTEIN from Mycobacterium smegmatis (511 aa), FASTA scores: opt: 1122, E(): 7.3e-63, (98.85% identity in 176 aa overlap). Also shows some similarity with Q55304 HYPOTHETICALK PROTEIN from Synechocystis sp. strain PCC 6803 (387 aa), FASTA scores: opt: 201, E(): 2.7e-05, (27.1% identity in 251 aa overlap); and P74254|SLR1173 HYPOTHETICAL 52.5 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (463 aa), FASTA scores: opt: 201, E(): 3.1e-05, (27.1% identity in 251 aa overlap). Also slightly similar to MTCY01B2_21 and DPO1_MYCTU DNA POLYMERASE I. TBparse score is 0.913.; hypothetical protein	4182934..4183992	Mycobacterium tuberculosis H37Rv	885795
NP_218250.1	CDS	Rv3733c	NC_000962.2	4184012	4184512	R	Rv3733c, (MTV025.081c), len: 166 aa. Conserved hypothetical protein, highly similar to Q9FCB0|2SCG58.03 PUTATIVE MUTT-LIKE PROTEIN from Streptomyces coelicolor (153 aa), FASTA scores: opt: 541, E(): 7.2e-29, (52.7% identity in 148 aa overlap); and BAB49143|MLR1881 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (156 aa), FASTA scores: opt: 526, E(): 7.2e-28, (52.65% identity in 150 aa overlap). TBparse score is 0.897.; hypothetical protein	complement(4184012..4184512)	Mycobacterium tuberculosis H37Rv	885721
NP_218251.1	CDS	Rv3734c	NC_000962.2	4184526	4185890	R	Rv3734c, (MTV025.082c), len: 454 aa. Hypothetical protein, highly similar to O69707|Y1E0_MYCTU|Rv3740c|MT3848|MTV025.088c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (448 aa), FASTA scores: opt: 1917, E(): 1.3e-111, (61.4% identity in 451 aa overlap); and similar to many other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. P71694|YE43_MYCTU|Rv1425|MT1468|MTCY21B4.43|MTCY493.29c (459 aa), FASTA scores: opt: 824, E(): 1.1e-43, (36.5% identity in 460 aa overlap); Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.25c (445 aa) FASTA scores: opt: 766, E(): 4.1e-40, (36.4% identity in 453 aa overlap); etc. Also similar to Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 331, E(): 4.3e-13, (32.9% identity in 468 aa overlap); and Q9X7A8|ML1244|MLCB1610.05 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 296, E(): 7e-11, (28.35% identity in 413 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Start site chosen by homology, but may extend further upstream to 93257. TBparse score is 0.923.; hypothetical protein	complement(4184526..4185890)	Mycobacterium tuberculosis H37Rv	885335
NP_218252.1	CDS	Rv3735	NC_000962.2	4186089	4186577	D	Rv3735, (MTV025.083), len: 162 aa. Conserved hypothetical protein, highly similar to several bacterial hypothetical proteins e.g. Q9UX41|ORF-C09_016|SSO0651|AAK40956 from Sulfolobus solfataricus (163 aa), FASTA scores: opt: 627, E(): 1.2e-34, (55.9% identity in 161 aa overlap); O26795|MTH699 from Methanobacterium thermoautotrophicum (168 aa), FASTA scores: opt: 616, E(): 6.7e-34, (56.1% identity in 155 aa overlap); |Q9Y9J9|APE2289 from Aeropyrum pernix (191 aa), FASTA scores: opt: 591, E(): 3.4e-32, (54.65% identity in 161 aa overlap) ; etc. Contains PS00435 Peroxidases proximal heme-ligand signature. TBparse score is 0.902.; hypothetical protein	4186089..4186577	Mycobacterium tuberculosis H37Rv	885318
NP_218253.1	CDS	Rv3736	NC_000962.2	4186634	4187695	D	Rv3736, (MTV025.084), len: 353 aa. Probable transcriptional regulator, araC/xylS family, similar to many transcriptional regulators and hypothetical proteins e.g. CAC38740 HYPOTHETICAL 35.4 KDA PROTEIN from Bradyrhizobium japonicum (318 aa), FASTA scores: opt: 438, E(): 2e-20, (29.4% identity in 306 aa overlap); Q9HZ25|PA3215 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (337 aa), FASTA scores: opt: 395, E(): 1.1e-17, (30.3% identity in 320 aa overlap); Q9HTN1|PA5324 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (356 aa), FASTA scores: opt: 313, E(): 1.8e-12, (25.85% identity in 329 aa overlap); Q9Z3Y6|PHBR TRANSCRIPTIONAL REGULATOR PHBR from Pseudomonas sp. 61-3 (379 aa), FASTA scores: opt: 271, E(): 8.3e-10, (22.95% identity in 357 aa overlap); etc. Also highly similar to Q06861|VIRS_MYCTU|Rv3082c|MTV013.03c POSSIBLE VIRULENCE-REGULATING PROTEIN from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 656, E(): 3.7e-34, (36.95% identity in 333 aa overlap); and similar to other hypothetical mycobacterial proteins e.g. P71663|YD95_MYCTU|Rv1395|MT1440|MTCY21B4.12 (344 aa). Contains helix-turn-helix motif at aa 245-266 (Score 1140, +3.07 SD). SEEMS BELONG TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS.TBparse score is 0.926.; transcriptional regulatory protein AraC/XylS-family	4186634..4187695	Mycobacterium tuberculosis H37Rv	885389
NP_218254.1	CDS	Rv3737	NC_000962.2	4187699	4189288	D	Rv3737, (MTV025.085), len: 529 aa. Probable conserved transmembrane protein, similar to others and also some hypothetical proteins e.g. AAK61331|THRE THREONINE EXPORT CARRIER from Corynebacterium glutamicum (Brevibacterium flavum) (489 aa), FASTA scores: opt: 773, E(): 1.8e-36, (37.25% identity in 424 aa overlap); Q9X8J0|SCE9.17 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (578 aa), FASTA scores: opt: 642, E(): 5.4e-29, (31.6% identity in 481 aa overlap) (shorter 119 aa at N-terminus); Q9CJU6|PM1895 HYPOTHETICAL PROTEIN from Pasteurella multocida (262 aa), FASTA scores: opt: 233, E(): 4.1e-06, (25.0% identity in 256 aa overlap); Q9S267|SCI30A.06 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (297 aa), FASTA scores: opt: 163, E(): 0.042, (29.65% identity in 263 aa overlap); etc. Also partially similar to O05435|Rv3910|MTCY15F10.01c|MTV028.01 HYPOTHETICAL 123.6 KDA PROTEIN from Mycobacterium tuberculosis (1184 aa) (34.4% identity in 125 aa overlap). TBparse score is 0.891; transmembrane protein	4187699..4189288	Mycobacterium tuberculosis H37Rv	885794
YP_178009.1	CDS	PPE66	NC_000962.2	4189285	4190232	R	Rv3738c, (MTV025.086c), len: 315 aa. Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O53265|Rv3018c|MTV012.32c (434 aa), FASTA scores: opt: 464, E(): 2.2e-17, (47.05% identity in 338 aa overlap). Probably a continuation of the upstream ORF MTV025.87c|Rv3739c|PPE67. At position 97470-72 a stop codon is present which interrupts a possibly longer ORF, observed in related ORFs MTV012_32 or MTCY21B4_4. The sequence has been checked and no errors were detected. A similar situation, but with a frameshift separating the ORFs is found in MTV012_36/MTV012_35. Sequence similarity is also seen with MTCY251_15; MTCY261_19; MLCB2492_30 from Mycobacterium leprae; MTCY10G2_10; MTY21C12_9; MTCI125_26; MTCY164_36; MTCY6A4_1. TBparse score is 0.920.; PPE family protein	complement(4189285..4190232)	Mycobacterium tuberculosis H37Rv	886262
YP_178010.1	CDS	PPE67	NC_000962.2	4190284	4190517	R	Rv3739c, (MTV025.087c), len: 77 aa. Member of the Mycobacterium tuberculosis PE family, showing high homology with O53269|Rv3022c|MTV012.36c (82 aa) FASTA scores: opt: 398, E(): 1.2e-19, (74.0% identity in 77 aa overlap); and similar to the N-termini of other PPE proteins e.g. O53265|Rv3018c|MTV012.32c (434 aa) FASTA scores: opt: 398, E(): 4.8e-19, (74.0% identity in 77 aa overlap). ORF ends at the stop codon at position 97470, which is not present in similar ORFs: MTV012_32, or MTCY21B4_4. Sequence homology with MTV012_32, and MTCY21B4_4 continues in the downstream ORF MTV025.086c|Rv3738c|PPE66. Sequence was checked, but no errors were detected. A similar situation, but with a frameshift separating the ORFs, is found in MTV012_36/MTV012_35. Also ORF MTV025.87c shows similarity to MTV03 _14; MTCY6A4_1; MTV035_8; MTV037_17; MLCB2492_30; MTCY261_19; MTCY251_15; MTCY3A2_23; MTCY28_16; etc.; PPE family protein	complement(4190284..4190517)	Mycobacterium tuberculosis H37Rv	886257
NP_218257.1	CDS	Rv3740c	NC_000962.2	4190833	4192179	R	Rv3740c, (MTV025.088c), len: 448 aa. Conserved hypothetical protein, highly similar to several other Mycobacterium tuberculosis hypothetical proteins e.g. O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa) FASTA scores: opt: 1917, E(): 2.3e-112, (61.4% identity in 451 aa overlap); Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.25c (445 aa) FASTA scores: opt: 858, E(): 3.4e-46, (37.4% identity in 460 aa overlap); Q10554|Y895_MYCTU|Rv0895|MT0919|MTCY31.23 (505 aa), FASTA scores: opt: 767, E(): 1.9e-40, (44.3% identity in 467 aa overlap); MTCY31_25; MTCY28_26; MTCY493_29; MTCY21B4_43; MTCY8D5_16; MTCY3A2_28; MTV013_8; MTY13E12_33; MTV013_9; MTY20B11_9; etc. Also similar to Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 319, E(): 1.7e-12, (30.9% identity in 453 aa overlap). TBparse score is 0.924.; hypothetical protein	complement(4190833..4192179)	Mycobacterium tuberculosis H37Rv	885781
NP_218258.1	CDS	Rv3741c	NC_000962.2	4192179	4192853	R	Rv3741c, (MTV025.089c), len: 224 aa. Possible oxidoreductase, probably combines with product of upstream ORF MTV025.090c to form a functional monooxygenase (EC 1.-.-.-), highly similar to C-terminal end of various oxidoreductases e.g. Q9APW3 AROMATIC-RING HYROXYLASE from Pseudomonas aeruginosa (508 aa), FASTA scores: opt: 549, E(): 5.9e-28, (56.1% identity in 155 aa overlap); Q9A588|CC2569 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (498 aa), FASTA scores: opt: 487, E(): 5.6e-24, (39.55% identity in 225 aa overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from Deinococcus radiodurans (833 aa), FASTA scores: opt: 460, E(): 4.7e-22, (38.5% identity in 226 aa overlap); etc. Also similar to C-terminal end of Mycobacterium tuberculosis proteins (generally monooxygenases) e.g. P96223|Rv3854c|MTCY01A6.14 HYPOTHETICAL 55.3 KDA PROTEIN (489 aa), FASTA scores: opt: 542, E(): 1.6e-27, (50.0% identity in 162 aa overlap); O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa), FASTA scores: opt: 462, E(): 2.2e-22, (37.15% identity in 226 aa overlap); O53300|Rv3083|MTV013.04 MONOXYGENASE (495 aa), FASTA scores: opt: 462, E(): 2.2e-22, (45.65% identity in 173 aa overlap); etc. Note similarity to MTCY01A6.14 and MTV013.04 continue in upstream ORF (MTV025.090c) after a gap of 100 aa. TBparse score is 0.911.; oxidoreductase	complement(4192179..4192853)	Mycobacterium tuberculosis H37Rv	885129
NP_218259.1	CDS	Rv3742c	NC_000962.2	4192850	4193245	R	Rv3742c, (MTV025.090c), len: 131 aa. Possible oxidoreductase, probably combines with product of downstream ORF MTV025.090c to form a functional monooxygenase (EC 1.-.-.-), highly similar to N-terminal end of various oxidoreductases e.g. Q9A588|CC2569 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (498 aa), FASTA scores: opt: 170, E(): 0.00048, (47.55% identity in 103 aa overlap); Q9APW3 AROMATIC-RING HYROXYLASE from Pseudomonas aeruginosa (508 aa) FASTA scores: opt: 160, E(): 0.0022, (50.55% identity in 87 aa overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from Deinococcus radiodurans (833 aa), FASTA scores: opt: 153, E(): 0.0097, (45.45% identity in 88 aa overlap); etc. Also similar to C-terminal end of Mycobacterium tuberculosis proteins (generally monooxygenases) e.g. P96223|Rv3854c|MTCY01A6.14 HYPOTHETICAL 55.3 KDA PROTEIN (489 aa), FASTA scores: opt: 140, E(): 0.044, (37.1% identity in 132 aa overlap); O53300|Rv3083|MTV013.04 MONOXYGENASE (495 aa) FASTA scores: opt: 133, E(): 0.13, (43.05% identity in 79 aa overlap); O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa), FASTA scores: opt: 110, E(): 4.1, (42.85% identity in 77 aa overlap); etc. Note similarity to MTCY01A6.14 and MTV013.04 continue in downstream ORF (MTV025.089c) after a gap of 100 aa. TBparse score is 0.915.; oxidoreductase	complement(4192850..4193245)	Mycobacterium tuberculosis H37Rv	885263
NP_218260.1	CDS	ctpJ	NC_000962.2	4193391	4195373	R	Rv3743c, (MTV025.091c), len: 660. Probable ctpJ, cation-transporting P-type ATPase (EC 3.6.1.-), transmembrane protein highly similar to others e.g. Q9ZBF3|SC9B5.27 PUTATIVE CATION-TRANSPORTING ATPASE from Streptomyces coelicolor (638 aa), FASTA scores: opt: 1635, E(): 2.5e-86, (62.25% identity in 63.95 aa overlap); Q59997|CADA|SLR0797 CADMIUM-TRANSPORTING ATPASE from Synechocystis sp. strain PCC 6803 (642 aa), FASTA scores: opt: 1474, E(): 4.3e-77, (42.4% identity in 604 aa overlap); P30336|CADA_BACFI PROBABLE CADMIUM-TRANSPORTING ATPASE from Bacillus firmus (723 aa), FASTA scores: opt: 1327, E(): 1.3e-68, (36.6% identity in 626 aa overlap); etc. Also highly similar to O53160|CTPD_MYCTU|Rv1469|MT1515|MTV007.16 PROBABLE CATION-TRANSPORTING P-TYPE ATPASE D from Mycobacterium tuberculosis (657 aa), FASTA scores: opt: 1845, E(): 2.3e-98, (55.85% identity in 650 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site and PS01229 Hypothetical family signature 2. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES). TBparse score is 0.903.; cation transporter P-type ATPase CtpJ	complement(4193391..4195373)	Mycobacterium tuberculosis H37Rv	885106
NP_218261.1	CDS	Rv3744	NC_000962.2	4195440	4195802	D	Rv3744, (MTV025.092), len: 120 aa. Probable transcriptional regulator, possible arsR family, highly similar to many e.g. Q9ZBF4|SC9B5.26c from Streptomyces coelicolor (120 aa), FASTA scores: opt: 480, E(): 2.4e-24, (63.25% identity in 117 aa overlap); O31844|YOZA YOZA REGULATOR from Bacillus subtilis (107 aa), FASTA scores: opt: 249, E(): 1.6e-09, (44.8% identity in 96 aa overlap); P30340|SMTB_SYNP7|SMTB from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (122 aa), FASTA scores: opt: 230, E(): 2.9e-08, (46.0% identity in 87 aa overlap); etc. Equivalent to AAK48216 from Mycobacterium tuberculosis strain CDC1551 (135 aa) but shorter 15 aa. Also similar to MTCY27_22; MTCY39_25; and MTCY441_12. Contains helix-turn-helix motif at aa 47-68 (Score 1815, +5.37 SD). SEEMS TO BELONG TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS.; transcriptional regulatory protein ArsR-family	4195440..4195802	Mycobacterium tuberculosis H37Rv	885418
NP_218262.1	CDS	Rv3745c	NC_000962.2	4195886	4196098	R	Rv3745c, (MTV025.093c), len: 70 aa. Conserved hypothetical protein, highly similar to others e.g. N-terminus of Q9X4E6 HYPOTHETICAL 13.4 KDA PROTEIN from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (124 aa), FASTA scores: opt: 279, E(): 4.4e-14, (59.4% identity in 69 aa overlap); N-terminus of Q9A2A6|CC3660 HYPOTHETICAL PROTEIN from Caulobacter crescentus (172 aa) FASTA scores: opt: 272, E(): 1.9e-13, (63.35% identity in 60 aa overlap); N-terminus of P74345|SLR1628 HYPOTHETICAL 14.5 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (134 aa), FASTA scores: opt: 233, E(): 1.3e-10, (54.85% identity in 62 aa overlap); etc. TBparse score is 0.894.; hypothetical protein	complement(4195886..4196098)	Mycobacterium tuberculosis H37Rv	885597
YP_178011.1	CDS	PE34	NC_000962.2	4196171	4196506	R	Rv3746c, (MTV025.094c), len: 111 aa. Probable member of the Mycobacterium tuberculosis PE family (see citation below), but without the glycine-rich C-terminal part, similar to N-termini of many e.g. O69737|Rv3872|MTV027.07 (99 aa) FASTA scores: opt: 306, E(): 1e-13, (50.5% identity in 99 aa overlap); O53215|Rv2490c|MTV008.46 (1660 aa) FASTA scores: opt: 125, E(): 0.99, (34.25% identity in 111 aa overlap). Also weakly similar to MTV008_46; MTCI418B_6; MTCY130_1; MTY25D10_11; MTCY1A11_25; MTCY21B4_13; MTCY21B4_27; MTCY493_2; MTCY28_25; etc. TBparse score is 0.900.; PE family protein	complement(4196171..4196506)	Mycobacterium tuberculosis H37Rv	885764
NP_218264.1	CDS	Rv3747	NC_000962.2	4196724	4197107	D	Rv3747, (MTV025.095), len: 127 aa. Hypothetical protein, highly similar to downstream ORF O69715|Rv3748|MTV025.096 CONSERVED HYPOTHETICAL PROTEIN (119 aa), FASTA scores: opt: 494, E(): 6e-27, (64.4% identity in 118 aa overlap). TBparse score is 0.924.; hypothetical protein	4196724..4197107	Mycobacterium tuberculosis H37Rv	885778
NP_218265.1	CDS	Rv3748	NC_000962.2	4197236	4197595	D	Rv3748, (MTV025.096), len: 119 aa. Hypothetical protein, highly similar to upstream ORF O69714|Rv3747|MTV025.095 CONSERVED HYPOTHETICAL PROTEIN (127 aa), FASTA scores: opt: 496, E(): 2.5e-28, (64.4% identity in 118 aa overlap). TBparse score is 0.871.; hypothetical protein	4197236..4197595	Mycobacterium tuberculosis H37Rv	885776
NP_218266.1	CDS	Rv3749c	NC_000962.2	4197628	4198137	R	Rv3749c, (MTV025.097c), len: 169 aa. Hypothetical protein, showing some similarity with O85864 HYPOTHETICAL 21.4 KDA PROTEIN from Sphingomonas aromaticivorans plasmid pNL1 (196 aa), FASTA scores: opt: 148, E(): 0.011, (32.7% identity in 104 aa overlap); Q9LCU6 HYPOTHETICAL 21.2 KDA PROTEIN from Arthrobacter sp. TM1 (192 aa), FASTA scores: opt: 125, E(): 0.35, (31.5% identity in 92 aa overlap); Q9L631|SPCB MYO-INOSITOL-2-DEHYDROGENASE from Streptomyces spectabilis (374 aa); Q9WJP8|PRE-S1 PRE-S1 PROTEIN (FRAGMENT) from Hepatitis B virus (88 aa); etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature.; hypothetical protein	complement(4197628..4198137)	Mycobacterium tuberculosis H37Rv	885384
NP_218267.1	CDS	Rv3750c	NC_000962.2	4198205	4198597	R	Rv3750c, (MTV025.098c), len: 130 aa. Possible excisionase, similar to others e.g. Q9LCU5 PUTATIVE EXCISIONASE from Arthrobacter sp. TM1 (174 aa) FASTA scores: opt: 297, E(): 1.2e-12, (40.35% identity in 114 aa overlap); O85865 PUTATIVE EXCISIONASE from Sphingomonas aromaticivorans plasmid pNL1 (152 aa), FASTA scores: opt: 223, E(): 7.3e-08, (39.15% identity in 97 aa overlap); Q9XBH1|XIS EXCISIONASE from Bacteroides fragilis (124 aa) FASTA scores: opt: 128, E(): 0.1, (30.7% identity in 88 aa overlap); etc. Also some similarity to transcriptional regulators. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c (114 aa) FASTA scores: opt: 224, E(): 4.9e-08, (42.7% identity in 82 aa overlap). Contains helix-turn-helix motif at aa 55-76 (Score 1925,+5.74 SD).; excisionase	complement(4198205..4198597)	Mycobacterium tuberculosis H37Rv	885807
NP_218268.1	CDS	Rv3751	NC_000962.2	4198874	4199089	D	Rv3751, (MTV025.099), len: 71 aa. Probable integrase (fragment), similar to part of many e.g. Q48908 INTEGRASE (FRAGMENT) from Mycobacterium paratuberculosis (191 aa), FASTA scores: opt: 206, E(): 5.5e-08, (57.65% identity in 59 aa overlap); Q9ZWV7|INT INTEGRASE from Corynephage 304L (395 aa), FASTA scores: opt: 156, E(): 0.00036, (45.75% identity in 59 aa overlap); Q9K722|BH3551 INTEGRASE (PHAGE-RELATED PROTEIN) from Bacillus halodurans (378 aa), FASTA scores: opt: 151, E(): 0.00079, (46.15% identity in 52 aa overlap); etc. Also similarity with various conjugative transposons. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. P71903|Rv2309c|MTCY3G12.25 (151 aa), FASTA scores: opt: 193, E(): 3.8e-07, (50.85% identity in 59 aa overlap); O53403|Rv1055|MTV017.08 (78 aa), FASTA scores: opt: 171, E(): 7.8e-06, (54.15% identity in 48 aa overlap); etc.; integrase	4198874..4199089	Mycobacterium tuberculosis H37Rv	885857
NP_218269.1	CDS	Rv3752c	NC_000962.2	4199247	4199705	R	Rv3752c, (MTV025.100c), len: 152 aa. Probable cytidine/deoxycytidylate deaminase (EC 3.5.4.-), equivalent to Q9CB32|ML2474 POSSIBLE CYTIDINE/DEOXYCYTIDYLATE DEAMINASE from Mycobacterium leprae (171 aa), FASTA scores: opt: 890, E(): 1.6e-50, (88.1% identity in 151 aa overlap). Also highly similar to other deaminases and hypothetical proteins e.g. Q9AK79|2SCD60.04c PUTATIVE DEAMINASE from Streptomyces coelicolor (143 aa), FASTA scores: opt: 559, E(): 2.9e-29, (66.45% identity in 146 aa overlap); Q9F9W7 CYTOSINE DEAMINASE from Bifidobacterium longum (143 aa) FASTA scores: opt: 512, E(): 3.1e-26, (54.85% identity in 144 aa overlap); P21335|YAAJ_BACSU HYPOTHETICAL 17.8 KDA PROTEIN from Bacillus subtilis (161 aa), FASTA scores: opt: 425, E(): 1.4e-20, (47.7% identity in 151 aa overlap); AAK74212|SP0020 CYTIDINE/DEOXYCYTIDYLATE DEAMINASE FAMILY PROTEIN from Streptococcus pneumoniae (155 aa), FASTA scores: opt: 401, E(): 4.7e-19, (46.25% identity in 147 aa overlap); P30134|YFHC_ECOLI|B2559 HYPOTHETICAL 20.0 KDA PROTEIN from Escherichia coli strain K12 (178 aa), FASTA scores: opt: 397, E(): 9.5e-19, (47.0% identity in 149 aa overlap); etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. TBparse score is 0.866.; cytidine/deoxycytidylate deaminase	complement(4199247..4199705)	Mycobacterium tuberculosis H37Rv	885586
NP_218270.1	CDS	Rv3753c	NC_000962.2	4199721	4200221	R	Rv3753c, (MTV025.101c), len: 166 aa. Conserved hypothetical protein, only equivalent to Q9CB33|ML2473 HYPOTHETICAL PROTEIN from Mycobacterium leprae (159 aa) FASTA scores: opt: 920 E(): 1.4e-52,, (88.6% identity in 158 aa overlap). TBparse score is 0.877.; hypothetical protein	complement(4199721..4200221)	Mycobacterium tuberculosis H37Rv	885505
NP_218271.1	CDS	tyrA	NC_000962.2	4200421	4201326	D	catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase	4200421..4201326	Mycobacterium tuberculosis H37Rv	885559
NP_218272.1	CDS	Rv3755c	NC_000962.2	4201289	4201888	R	Rv3755c, (MTV025.103c), len: 199 aa. Conserved hypothetical protein showing similarity to CAC47343|SMC03980 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (196 aa) FASTA scores: opt: 244, E(): 4.1e-09, (30.9% identity in 191 aa overlap); Q9I2B5|PA1994 from Pseudomonas aeruginosa (187 aa), FASTA scores: opt: 226, E(): 6e-08, (29.9% identity in 194 aa overlap); and Q98N73|MLR0268 HYPOTHETICAL PROTEIN (183 aa), FASTA scores: opt: 234, E(): 1.8e-08, (27.05% identity in 185 aa overlap). TBparse score is 0.925.; hypothetical protein	complement(4201289..4201888)	Mycobacterium tuberculosis H37Rv	885298
NP_218273.1	CDS	proZ	NC_000962.2	4201894	4202613	R	Rv3756c, (MTV025.104c), len: 239 aa. Possible proZ, osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58609|Q99RI4|OPUCB|SA2236|SAV2447 OPUCB PROTEIN (PROBABLE GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER) from Staphylococcus aureus (211 aa) FASTA scores: opt: 434, E(): 2.5e-18, (36.6% identity in 194 aa overlap); Q45461|OPBB_BACSU|OPUBB|PROW CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN (mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine) from Bacillus subtilis (217 aa), FASTA scores: opt: 402, E(): 1.9e-16, (32.0% identity in 203 aa overlap); O34878|OPCB_BACSU|OPUCB GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (217 aa), FASTA scores: opt: 385, E(): 1.8e-15, (30.2% identity in 222 aa overlap); P39775|O34657|OPUBD|PROZ|OPBD_BACSU CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (226 aa) FASTA scores: opt: 350, E(): 2e-13, (31.75% identity in 208 aa overlap); etc. COULD BELONG TO THE CYSTW SUBFAMILY. TBparse score is 0.911.; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter PROZ	complement(4201894..4202613)	Mycobacterium tuberculosis H37Rv	885534
NP_218274.1	CDS	proW	NC_000962.2	4202610	4203299	R	Rv3757c, (MTV025.105c), len: 225 aa. Possible proW, osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58607|Q99RI6|OPUCD|SA2234|SAV2445 OPUCD PROTEIN (PROBABLE GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER) from Staphylococcus aureus (231 aa) FASTA scores: opt: 364, E(): 7.1e-15, (30.0% identity in 220 aa overlap); Q45461|OPBB_BACSU|OPUBB|PROW CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN (mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine) from Bacillus subtilis (217 aa), FASTA scores: opt: 348, E(): 6.2e-14, (31.05% identity in 206 aa overlap); O34878|OPCB_BACSU|OPUCB GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (217 aa), FASTA scores: opt: 343, E(): 1.2e-13, (30.1% identity in 206 aa overlap); O34742|OPCD_BACSU|OPUCD GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (229 aa) FASTA scores: opt: 337, E(): 2.9e-13, (31.1% identity in 193 aa overlap); etc. COULD BELONG TO THE CYSTW SUBFAMILY.; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter PROW	complement(4202610..4203299)	Mycobacterium tuberculosis H37Rv	885581
NP_218275.1	CDS	proV	NC_000962.2	4203287	4204417	R	Rv3758c, (MTV025.106c), len: 376 aa. Possible proV, osmoprotectant transport ATP-binding protein ABC transporter (see citation below), highly similar to osmoprotection proteins (proV) involved in glycine betaine/L-proline/choline transport, e.g. BAB58610|Q99RI3|OPUCA|SA2237|SAV2448 GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER (ATP-BINDING) from Staphylococcus aureus (410 aa), FASTA scores: opt: 816, E(): 8.4e-39, (39.5% identity in 362 aa overlap); O34992|OPCA_BACSU|OPUCA GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (380 aa), FASTA scores: opt: 807, E(): 2.5e-38, (40.55% identity in 333 aa overlap); Q45460|OPBA_BACSU|OPUBA|PROV CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (381 aa), FASTA scores: opt: 801, E(): 5.6e-38, (40.65% identity in 337 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporter family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.896.; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter PROV	complement(4203287..4204417)	Mycobacterium tuberculosis H37Rv	886293
NP_218276.1	CDS	proX	NC_000962.2	4204426	4205373	R	Rv3759c, (MTV025.107c), len: 315 aa. Possible proX, osmoprotectant-binding lipoprotein component of osmoprotectant transport system (see citation below), similar to osmoprotection proteins (proX) involved in glycine betaine/L-proline/choline transport, e.g. AAK79442|CAC1474 PROLINE/GLYCINE BETAINE ABC TRANSPORT SYSTEM PERIPLASMIC COMPONENT from Clostridium acetobutylicum (303 aa), FASTA scores: opt: 308, E(): 1.2e-11, (27.4% identity in 314 aa overlap); Q9X4J2|PROXL|SCE19A.33 PROXL PROTEIN from Streptomyces coelicolor (322 aa), FASTA scores: opt: 302, E(): 3e-11, (27.2% identity in 327 aa overlap); O29280|AF0982 OSMOPROTECTION PROTEIN (PROX) from Archaeoglobus fulgidus (292 aa), FASTA scores: opt: 235, E(): 3.4e-07, (23.15% identity in 285 aa overlap); etc. Also similar to MTV006_16 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis, and MLU15180_43 HYPOTHETICAL PROTEIN from Mycobacterium leprae. Equivalent to AAK48230 from Mycobacterium tuberculosis strain CDC1551 (343 aa) but shorter 28 aa. Contains probable N-terminal signal sequence.; osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein PROX	complement(4204426..4205373)	Mycobacterium tuberculosis H37Rv	886270
NP_218277.1	CDS	Rv3760	NC_000962.2	4205538	4205840	D	Rv3760, (MTV025.108), len: 100 aa. Possible conserved membrane protein, equivalent to Q50094|ML2366|MLCB12.11c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (113 aa), FASTA scores: opt: 423, E(): 1.2e-20, (67.7% identity in 99 aa overlap). Also similar with Q9JST1|NMA2149 PUTATIVE INNER MEMBRANE HYPOTHETICAL PROTEIN from Neisseria meningitidis (serogroup A) (104 aa), FASTA scores: opt: 113, E(): 0.95, (33.85% identity in 62 aa overlap); and showing similarity with Q9ZAX7 ABC TRANSPORTER MEMBRANE PROTEIN SUBUNIT from Streptococcus mutans (498 aa), FASTA scores: opt: 108, E(): 6.7, (42.35% identity in 85 aa overlap) (similarity at C-terminus); and P33108|SECY_MICLU PREPROTEIN TRANSLOCASE SECY SUBUNIT from Micrococcus luteus (Micrococcus lysodeikticus) (436 aa), FASTA scores: opt: 106, E(): 8.2, (29.05% identity in 86 aa overlap). Equivalent to AAK48231 from Mycobacterium tuberculosis strain CDC1551 (117 aa) but shorter 17 aa. TBparse score is 0.880.; hypothetical protein	4205538..4205840	Mycobacterium tuberculosis H37Rv	886093
NP_218278.1	CDS	fadE36	NC_000962.2	4205862	4206917	R	Rv3761c, (MTV025.109c), 351 aa. Possible fadE36, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many conserved hypothetical proteins and showing some similarity with few acyl-CoA dehydrogenases, e.g. Q9APX7|FADE36 FADE36 PROTEIN from Pseudomonas aeruginosa (360 aa), FASTA scores: opt: 147, E(): 0.046, (26.15% identity in 214 aa overlap); part of AAB52261.2|U97002 protein similar to acyl-CoA dehydrogenases and epoxide hydrolases from Caenorhabditis elegans (985 aa), FASTA score: (31.2% identity in 324 aa overlap). C-terminal part is highly similar to Q50095|U1740AK|MLU15183_45 hypothetical protein from Mycobacterium leprae cosmid B174 (122 aa), FASTA scores: opt: 341, E(): 7.3e-15, (57.6% identity in 99 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. TBparse score is 0.910.; acyl-CoA dehydrogenase	complement(4205862..4206917)	Mycobacterium tuberculosis H37Rv	886098
NP_218279.1	CDS	Rv3762c	NC_000962.2	4206996	4208876	R	Rv3762c, (MTV025.110c), len: 626 aa. Possible hydrolase (EC 3.-.-.-), highly similar to hypothetical proteins and beta-lactamases (EC 3.5.2.6) e.g. Q9RL04|SC5G9.23 HYPOTHETICAL 70.3 KDA PROTEIN from Streptomyces coelicolor (648 aa), FASTA scores: opt: 2088, E(): 3.7e-124, (52.9% identity in 624 aa overlap); P32717|YJCS_ECOLI|B4083 HYPOTHETICAL 73.2 KDA PROTEIN from Escherichia coli strain K12 (661 aa), FASTA scores: opt: 1911, E(): 5.7e-113, (46.9% identity in 631 aa overlap); Q9A824|CC1540 METALLO-BETA-LACTAMASE FAMILY PROTEIN from Caulobacter crescentus (647 aa), FASTA scores: opt: 1891, E(): 1e-111, (48.55% identity in 628 aa overlap); Q08347|YOL164W CHROMOSOME XV READING FRAME ORF from Saccharomyces cerevisiae (Baker's yeast) (646 aa) FASTA scores: opt: 1829, E(): 8.4e-108, (45.7% identity in 615 aa overlap); Q9I5I9|PA0740 PROBABLE BETA-LACTAMASE from Pseudomonas aeruginosa (658 aa), FASTA scores: opt: 1699, E(): 1.4e-99, (43.15% identity in 630 aa overlap); Q52556|SDSA ALKYL SULFATASE (protein involved in the degradation of sulfate esters of long-chain primaryal cohols e.g. SDS sodium dodecyl sulfate) from Pseudomonas sp (528 aa), FASTA scores: opt: 841, E(): 1.7e-45, (33.7% identity in 534 aa overlap); etc. N-terminual end also highly similar to Q48790|SEPA SEPA PROTEIN (protein implicated in cell separation) from Listeria monocytogenes (391 aa), FASTA scores: opt: 1256, E(): 8.3e-72, (49.6% identity in 363 aa overlap). Also slight similarity to P96253|Rv0407|MTCY22G10.03 HYPOTHETICAL 37.0 KDA PROTEIN from Mycobacterium tuberculosis (336 aa). TBparse score is 0.897.; hydrolase	complement(4206996..4208876)	Mycobacterium tuberculosis H37Rv	886096
NP_218280.1	CDS	lpqH	NC_000962.2	4209047	4209526	D	Rv3763, (MTV025.111), len: 159 aa. lpqH, conserved 19 KDa lipoprotein antigen precursor (see citations below), equivalent to P31502|19KD_MYCIT|MI22 19 KDA LIPOPROTEIN ANTIGEN PRECURSOR (MI22 ANTIGEN) from Mycobacterium intracellulare (162 aa), FASTA scores: opt: 773, E(): 6.2e-35, 75.95(% identity in 162 aa overlap); P46733|19KD_MYCAV 19 KDA LIPOPROTEIN ANTIGEN PRECURSOR from Mycobacterium avium (161 aa), FASTA scores: opt: 743, E(): 2.5e-33, (72.5% identity in 160 aa overlap); and Q9X7A5|LPQH|ML1966 POSSIBLE LIPOPROTEIN from Mycobacterium leprae FASTA scores: opt: 371, E(): 2.2e-13, (42.6% identity in 162 aa overlap). POSSIBLY ATTACHED TO THE MEMBRANE BY A LIPID ANCHOR. SIMILAR TO OTHER MYCOBACTERIUM 19 KDA ANTIGEN. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; 19 kDa lipoprotein antigen precursor LPQH	4209047..4209526	Mycobacterium tuberculosis H37Rv	886097
NP_218281.1	CDS	Rv3764c	NC_000962.2	4209582	4211009	R	Rv3764c, (MTV025.112c), len: 475 aa. Possible histidine protein kinase (EC 2.7.3.-), part of a two-component regulatory system, similar to others e.g. Q9ADN6|2SC10A7.25 PUTATIVE TWO COMPONENT SYSTEM HISTIDINE KINASE from Streptomyces coelicolor (524 aa), FASTA scores: opt: 1332, E(): 5.4e-70, (49.9% identity in 477 aa overlap); Q9L3C1|KB|CAC42479 PUTATIVE HISTIDINE KINASE from Amycolatopsis mediterranei (469 aa), FASTA scores: opt: 515, E(): 1.4e-22, (36.1% identity in 313 aa overlap); P72560 HISTIDINE PROTEIN KINASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (438 aa), FASTA scores: opt: 480, E(): 1.4e-20, (40.1% identity in 232 aa overlap); P30847|P76401|BAES_ECOLI|B2078 SENSOR PROTEIN from Escherichia coli strain K12 (467 aa); etc. Also similar to others from Mycobacterium tuberculosis e.g. P96368|Rv1032c|MTCY10G2.17 (509 aa), FASTA scores: opt: 1007, E(): 4e-51, (43.5% identity in 416 aa overlap); and P71815|Rv0758|MTCY369.03 (485 aa), FASTA scores: opt: 738, E(): 1.6e-35, (28.6% identity in 438 aa overlap). Equivalent to AAK48235 from Mycobacterium tuberculosis strain CDC1551 (506 aa) but shorter 31 aa. TBparse score is 0.916.; two component sensor kinase	complement(4209582..4211009)	Mycobacterium tuberculosis H37Rv	886094
NP_218282.1	CDS	Rv3765c	NC_000962.2	4211080	4211784	R	Rv3765c, (MTV025.113c), len: 234 aa. Probable response regulator of a two-component regulatory system, highly similar to others e.g. Q9ADN7|2SC10A7.24 PUTATIVE TWO COMPONENT SYSTEM RESPONSE REGULATOR from Streptomyces coelicolor (271 aa), FASTA scores: opt: 1111, E(): 4.8e-63, (72.3% identity in 231 aa overlap); Q9F161 RESPONSE REGULATOR from Corynebacterium glutamicum (Brevibacterium flavum) (232 aa), FASTA scores: opt: 692, E(): 1.2e-36, (46.0% identity in 226 aa overlap); Q9KZU5|SCD84.23c PUTATIVE TWO-COMPONENT SYSTEN RESPONSE REGULATOR from Streptomyces coelicolor (248 aa), FASTA scores: opt: 674, E(): 1.7e-35, (44.05% identity in 236 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q50806|Rv1033c|MTCY10G2.16 RESPONSE REGULATOR HOMOLOG (257 aa), FASTA scores: opt: 947, E(): 1e-52, (59.5% identity in 232 aa overlap); P71814|Rv0757|MTCY369.02 PHOP-LIKE PROTEIN (247 aa) FASTA scores: opt: 829, E(): 2.8e-45, (54.65% identity in 225 aa overlap); O53894|Rv0981|MTV044.09 (230 aa), FASTA scores: opt: 662, E(): 9e-35, (44.65% identity in 224 aa overlap); and also similar to MTCY31_34; MTCY19H5_20; MTY13628_5; MTCY20G9_17; and to MLCB57_27 from Mycobacterium leprae; and MBY13627_3 from Mycobacterium bovis BCG. Equivalent to AAK48236 from Mycobacterium tuberculosis strain CDC1551 (286 aa) but shorter 52 aa. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION. TBparse score is 0.899.; two component transcriptional regulatory protein	complement(4211080..4211784)	Mycobacterium tuberculosis H37Rv	886100
NP_218283.1	CDS	Rv3766	NC_000962.2	4212293	4212982	D	Rv3766, (MTV025.114), len: 229 aa. Hypothetical unknown protein. Segment 183 to 229 highly similar to C-terminal part of O06288|Rv3594|MTCY07H7B.28c CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (275 aa), FASTA scores: opt: 128, E(): 0.92, (46.8% identity in 47 aa overlap). TBparse score is 0.943.; hypothetical protein	4212293..4212982	Mycobacterium tuberculosis H37Rv	886099
NP_218284.1	CDS	Rv3767c	NC_000962.2	4212996	4213940	R	Rv3767c, (MTV025.115c, MTCY13D12.01), len: 314 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P96823|Rv0146|MTCI5.20 HYPOTHETICAL 34.0 KDA PROTEIN (310 aa), FASTA scores: opt: 909, E(): 5.3e-50, (48.1% identity in 316 aa overlap); O53686|Rv0281|MTV035.09 (302 aa), FASTA scores: opt: 802, E(): 2.8e-43, (45.2% identity in 314 aa overlap); Q50726|YX99_MYCTU|Rv3399|MT3507|MTCY78.29c (348 aa), FASTA scores: opt: 796, E(): 7.6e-43, (45.35% identity in 302 aa overlap); MTCY78_30; MTCY31_23; MTCY210_45; MTCY4C12_14; MTY13D12_21, MTCI5_19; MTCY180_22; etc. Contains probable N-terminal signal sequence; hypothetical protein	complement(4212996..4213940)	Mycobacterium tuberculosis H37Rv	886101
NP_218285.1	CDS	Rv3768	NC_000962.2	4214070	4214429	D	Rv3768, (MTCY13D12.02), len: 119 aa. Hypothetical unknown protein.; hypothetical protein	4214070..4214429	Mycobacterium tuberculosis H37Rv	886102
NP_218286.1	CDS	Rv3769	NC_000962.2	4214615	4214887	D	Rv3769, (MTCY13D12.03), len: 90 aa. Hypothetical unknown protein, possible coiled-coil protein.; hypothetical protein	4214615..4214887	Mycobacterium tuberculosis H37Rv	885239
NP_218287.1	CDS	Rv3770c	NC_000962.2	4215200	4215775	R	Rv3770c, (MTCY13D12.04c), len: 191 aa. Hypothetical unknown leu-rich protein.; hypothetical protein	complement(4215200..4215775)	Mycobacterium tuberculosis H37Rv	886104
YP_178012.1	CDS	Rv3770A	NC_000962.2	4215881	4216063	R	Rv3770A, len: 60 aa. Probable remnant of a transposase, similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 204, E(): 1e-07, (80.5% identity in 41 aa overlap). Continuation of Rv3770B.; hypothetical protein	complement(4215881..4216063)	Mycobacterium tuberculosis H37Rv	3205079
YP_178013.1	CDS	Rv3770B	NC_000962.2	4216078	4216269	R	Rv3770B, len: 63 aa. Probable remnant of a transposase, similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: 379, E(): 1.6e-21, (93.55% identity in 62 aa overlap). Continues as Rv3770A.; hypothetical protein	complement(4216078..4216269)	Mycobacterium tuberculosis H37Rv	3205080
NP_218288.1	CDS	Rv3771c	NC_000962.2	4216404	4216730	R	Rv3771c, (MTCY13D12.05c), len: 108 aa. Hypothetical protein, highly similar, but shorter 81 aa, to P71640|Rv2811|MTCY16B7.32c HYPOTHETICAL 21.1 KDA PROTEIN from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 469, E(): 2.7e-25, (73.15% identity in 108 aa overlap); hypothetical protein	complement(4216404..4216730)	Mycobacterium tuberculosis H37Rv	886103
NP_218289.1	CDS	hisC2	NC_000962.2	4217134	4218195	D	Rv3772, (MTCY13D12.06), len: 353 aa. Probable hisC2, histidinol-phosphate aminotransferase (EC 2.6.1.9), highly similar to Q9ZBY8|SCD78.11 PUTATIVE HISTIDINOL-PHOPHATE AMINOTRANSFERASE from Streptomyces coelicolor (359 aa), FASTA scores: opt: 1165, E(): 7.1e-64, (52.55% identity in 356 aa overlap); and similar to many e.g. Q9EYX2 from Gardnerella vaginalis (317 aa) FASTA scores: opt: 814, E(): 1.7e-42, (45.15% identity in 308 aa overlap); Q9CMI7|HISH_1PM0838|HISH from Pasteurella multocida (365 aa), FASTA scores: opt: 701, E(): 1.5e-35, (35.05% identity in 351 aa overlap); O07131|HIS8_METFL|HISC|HISH from Methylobacillus flagellatum (368 aa), FASTA scores: opt: 645, E(): 4e-32, (34.5% identity in 345 aa overlap); etc. Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE.; putative aminotransferase	4217134..4218195	Mycobacterium tuberculosis H37Rv	886105
NP_218290.1	CDS	Rv3773c	NC_000962.2	4218241	4218825	R	Rv3773c, (MTCY13D12.07c), len: 194 aa. Hypothetical protein, highly similar to C-terminal end of O53773|Rv0576|MTV039.14 POSSIBLE TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (434 aa), FASTA scores: opt: 575, E(): 8.3e-30, (47.4% identity in 192 aa overlap); and some similarity with other proteins from Mycobacterium tuberculosis e.g. P71985|Rv1727|MTCY04C12.12 (189 aa) FASTA scores: opt: 176, E(): 0.00022, (31.1% identity in 180 aa overlap).; hypothetical protein	complement(4218241..4218825)	Mycobacterium tuberculosis H37Rv	886095
NP_218291.1	CDS	echA21	NC_000962.2	4218849	4219673	D	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase	4218849..4219673	Mycobacterium tuberculosis H37Rv	886106
NP_218292.1	CDS	lipE	NC_000962.2	4219685	4220932	D	Rv3775, (MTCY13D12.09), len: 415 aa. Probable lipE, hydrolase lipase (EC 3.1.-.-), equivalent to Q9CD95|LIPE|ML0119 PROBABLE HYDROLASE from Mycobacterium leprae (411 aa), FASTA scores: opt: 2418, E(): 6.4e-144, (84.75% identity in 406 aa overlap). Also similar to other esterases e.g. Q9ABH2|CC0255 ESTERASE A from Caulobacter crescentus (374 aa), FASTA scores: opt: 427, E(): 2.4e-19, (28.9% identity in 391 aa overlap); O87861|ESTA ESTERASE A from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 417, E(): 1e-18, (31.0% identity in 361 aa overlap); Q9RK50|SCF12.08 PUTATIVE ESTERASE from Streptomyces coelicolor (376 aa), FASTA scores: opt: 385, E(): 1e-16, (31.35% identity in 373 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. P71778|Rv1497|MTCY277.19 HYPOTHETICAL 45.8 KDA PROTEIN (429 aa), FASTA scores: opt: 457, E(): 3.5e-21, (30.4% identity in 395 aa overlap).; lipase LipE	4219685..4220932	Mycobacterium tuberculosis H37Rv	886269
NP_218293.1	CDS	Rv3776	NC_000962.2	4221089	4222648	D	Rv3776, (MTCY13D12.10), len: 519 aa. Conserved hypothetical protein, highly similar to Q10709|YL00_MYCTU|Rv2100|MTCY49.40 HYPOTHETICAL 58.9 KDA PROTEIN from Mycobacterium tuberculosis (550 aa) FASTA scores: opt: 1646, E(): 1.2e-83, (77.85% identity in 510 aa overlap) (homology from potential start at 7744); and similar to other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O33266|Rv0336|MTCY279.03 (503 aa) FASTA scores: opt: 682, E(): 2.2e-30, (41.65% identity in 497 aa overlap).; hypothetical protein	4221089..4222648	Mycobacterium tuberculosis H37Rv	888953
NP_218294.1	CDS	Rv3777	NC_000962.2	4222694	4223680	D	Rv3777, (MTCY13D12.11), len: 328 aa. Probable oxidoreductase (EC 1.-.-.-), equivalent to Q9CD96|ML0118 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (336 aa) FASTA scores: opt: 1661, E(): 1.1e-87, (76.0% identity in 325 aa overlap). Also highly similar to many e.g. Q9XA55|SCGD3.24c PUTATIVE QUINONE OXIDOREDUCTASE (EC 1.6.5.5) from Streptomyces coelicolor (326 aa) FASTA scores: opt: 1118, E(): 1.3e-64, (59.6% identity in 312 aa overlap); O65423|F18E5.200|F17L22.40|AT4G21580 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Arabidopsis thaliana (Mouse-ear cress) (325 aa), FASTA scores: opt: 1110, E(): 3e-56, (52.15% identity in 326 aa overlap); Q98FI0|MLL3767 NADPH QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (326 aa), FASTA scores: opt: 980, E(): 7.9e-49, (47.85% identity in 324 aa overlap); etc.; oxidoreductase	4222694..4223680	Mycobacterium tuberculosis H37Rv	886110
NP_218295.1	CDS	Rv3778c	NC_000962.2	4223699	4224895	R	Rv3778c, (MTCY13D12.12c), len: 398 aa. Possible aminotransferase (EC 2.6.1.-), equivalent to Q9CD97|ML0117 HYPOTHETICAL PROTEIN from Mycobacterium leprae (398 aa) FASTA scores: opt: 2141, E(): 1.2e-123, (83.4% identity in 398 aa overlap). Also similar to other aminotransferases and cysteine desulfurases e.g. Q9K3K6|SCG20A.34 PUTATIVE AMINOTRANSFERASE from Streptomyces coelicolor (400 aa), FASTA scores: opt: 723, E(): 6.5e-37, (36.3% identity in 402 aa overlap); Q9KSS2|VC1184 NIFS-RELATED PROTEIN (AMINOTRANSFERASE-RELATED) from Vibrio cholerae (416 aa) FASTA scores: opt: 595, E(): 4.5e-29, (31.35% identity in 405 aa overlap); Q98NK4|MLR0102 AMINOTRANSFERASE from Rhizobium loti (Mesorhizobium loti) (425 aa), FASTA scores: opt: 563, E(): 4.2e-27, (29.4% identity in 408 aa overlap); Q9RY03|DR0151 NIFS-RELATED PROTEIN from Deinococcus radiodurans (401 aa), FASTA scores: opt: 484, E(): 2.7e-22, (32.35% identity in 399 aa overlap); Q9A766|CC1860 AMINOTRANSFERASE CLASS V from Caulobacter crescentus (408 aa), FASTA scores: opt: 390, E(): 1.5e-16, (27.85% identity in 413 aa overlap); etc.; aminotransferase	complement(4223699..4224895)	Mycobacterium tuberculosis H37Rv	886116
NP_218296.1	CDS	Rv3779	NC_000962.2	4224985	4226985	D	Rv3779, (MTCY13D12.13), len: 666 aa. Probable conserved transmembrane ala-, leu-rich protein, equivalent to Q9CD98|ML0116 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (654 aa), FASTA scores: opt: 1991, E(): 2e-112, (66.5% identity in 666 aa overlap). Shows some similarity with Q9RRU0|DR2395 PUTATIVE NA+/H+ ANTIPORTER from Deinococcus radiodurans (458 aa), FASTA scores: opt: 138, E(): 0.69, (31.9% identity in 138 aa overlap).; transmembrane protein alanine and leucine rich	4224985..4226985	Mycobacterium tuberculosis H37Rv	886107
NP_218297.1	CDS	Rv3780	NC_000962.2	4226989	4227525	D	Rv3780, (MTCY13D12.14), len: 178 aa. Conserved hypothetical protein, equivalent to Q9CD99|ML0115 HYPOTHETICAL 19.1 KDA PROTEIN from Mycobacterium leprae (174 aa), FASTA scores: opt: 903, E(): 2.3e-48, (82.95% identity in 170 aa overlap). Also highly similar to Q9XA56|SCGD3.23c HYPOTHETICAL 19.5 KDA PROTEIN from Streptomyces coelicolor (179 aa), FASTA scores: opt: 692, E(): 1.8e-35, (65.9% identity in 170 aa overlap). Note that this putative protein is 4 aa longer at the N-terminus compared to previous annotation (in Nature 393: 537-544 (1998)).; hypothetical protein	4226989..4227525	Mycobacterium tuberculosis H37Rv	886115
NP_218298.1	CDS	rfbE	NC_000962.2	4227529	4228350	D	Rv3781, (MTCY13D12.15), len: 273 aa. Probable rfbE, polysaccharide-transport ATP-binding protein ABC transporter, involved in O-antigen/lipopolysaccharides (LPS) transport (see Braibant et al., 2000), equivalent to Q9CDA0|ML0114 PUTATIVE ABC TRANSPORTER ATP-BINDING COMPONENT from Mycobacterium leprae (272 aa), FASTA scores: opt: 1581, E(): 3e-83, (91.4% identity in 267 aa overlap). Also highly similar to AAK71283 LPS/O-ANTIGEN EXPORT PERMEASE from Coxiella burnetii (258 aa), FASTA scores: opt: 793, E(): 2.5e-38, (45.45% identity in 253 aa overlap); Q9PAF0|XF2568 ABC TRANSPORTER ATP-BINDING PROTEIN from Xylella fastidiosa (246 aa), FASTA scores: opt: 758, E(): 2.4e-36, (47.75% identity in 243 aa overlap); Q56903|RFBE_YEREN O-ANTIGEN EXPORT SYSTEM ATP-BINDING PROTEIN from Yersinia enterocolitica (239 aa) (see Zhang et al., 1993), FASTA scores: opt: 697, E(): 7e-33, (48.65% identity in 224 aa overlap); Q50863|RFBB_MYXXA O-ANTIGEN EXPORT SYSTEM ATP-BINDING from Myxococcus xanthus (437 aa), FASTA scores: opt: 605, E(): 2e-27, (42.05% identity in 207 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).; o-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE	4227529..4228350	Mycobacterium tuberculosis H37Rv	886113
YP_178014.1	CDS	Rv3782	NC_000962.2	4228347	4229261	D	Rv3782, (MTCY13D12.16), len: 304 aa. Possible L-rhamnosyltransferase (EC 2.4.1.-), equivalent to Q9CDA1|RFBE|ML0113 PUTATIVE GLYCOSYL TRANSFERASE from Mycobacterium leprae (283 aa), FASTA scores: opt: 1583, E(): 9.3e-96, (81.6% identity in 277 aa overlap). Also some similarity with AAK68916|WCFN PUTATIVE GLYCOSYLTRANSFERASE from Bacteroides fragilis (291 aa) FASTA scores: opt: 241, E(): 2.1e-08, (30.75% identity in 195 aa overlap); O58161|PH0424 HYPOTHETICAL 40.5 KDA PROTEIN from Pyrococcus horikoshii (348 aa), FASTA scores: opt: 194, E(): 2.8e-05, (23.85% identity in 302 aa overlap); O26448|MTH348 RHAMNOSYL TRANSFERASE from Methanothermobacter thermautotrophicus (313 aa), FASTA scores: opt: 177, E(): 0.00033, (28.2% identity in 333 aa overlap); O07868|CPS19BQ PUTATIVE RHAMNOSYL TRANSFERASE FASTA from Streptococcus pneumoniae (300 aa), FASTA scores: opt: 156, E(): 0.0074, (25.45% identity in 232 aa overlap); and other putative transferases. Note that C-terminal end shows some similarity with part of Q05161|RFB O-ANTIGEN BIOSYNTHESIS PROTEIN B from Escherichia coli strain 0101. Note that previously known as rfbE.; rfbE; L-rhamnosyltransferase	4228347..4229261	Mycobacterium tuberculosis H37Rv	886114
NP_218300.1	CDS	rfbD	NC_000962.2	4229258	4230100	D	Rv3783, (MTCY13D12.17), len: 280 aa. Probable rfbD, polysaccharide-transport integral membrane protein ABC transporter (see Braibant et al., 2000), involved in O-antigen/lipopolysaccharides (LPS) transport, equivalent to Q9CDA2|ML0112 PUTATIVE ABC TRANSPORTER COMPONENT from Mycobacterium leprae (276 aa), FASTA scores: opt: 1646, E(): 4e-102, (84.3% identity in 280 aa overlap). Also highly similar to Q9PAF1|XF2567 ABC TRANSPORTER PERMEASE PROTEIN from Xylella fastidiosa (267 aa), FASTA scores: opt: 723, E(): 7.6e-41, (41.3% identity in 259 aa overlap); and similar to others e.g. Q56902|RFBD_YEREN O-ANTIGEN EXPORT SYSTEM PERMEASE PROTEIN from Yersinia enterocolitica (259 aa) (see Zhang et al., 1993), FASTA scores: opt: 566, E(): 2e-30, (28.05% identity in 264 aa overlap); Q06955|RFBH RFBH PROTEIN (involved in the export of lipopolysaccharide) (alias Q9KVA3|VC0246) LIPOPOLYSACCHARIDE/O-ANTIGEN TRANSPORT PROTEIN from Vibrio cholerae (257 aa), FASTA scores: opt: 358, E(): 1.3e-16, (24.4% identity in 258 aa overlap); Q9HTB8|WZM|PA5451 MEMBRANE SUBUNIT OF A-BAND LPS EFFLUX TRANSPORTER from Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 263, E(): 2.7e-10, (25.45% identity in 263 aa overlap); etc. BELONGS TO THE ABC-2 SUBFAMILY OF INTEGRAL MEMBRANE PROTEINS.; O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD	4229258..4230100	Mycobacterium tuberculosis H37Rv	886111
YP_178015.1	CDS	Rv3784	NC_000962.2	4230256	4231236	D	Rv3784, (MTCY13D12.18), len: 326 aa. Possible dTDP-glucose 4,6-dehydratase (EC 4.2.1.46), but experimental study shown that the purified protein didn't have dTDP-glucose dehydratase (rmlB) activity (see citation below). Similar to others e.g. Q9YCT1|APE1180 LONG HYPOTHETICAL DTDP-GLUCOSE 4,6-DEHYDRATASE from Aeropyrum pernix (330 aa) FASTA scores: opt: 598, E(): 3.7e-30, (34.9% identity in 315 aa overlap); O27817|MTH1789 DTDP-GLUCOSE 4,6-DEHYDRATASE from Methanothermobacter thermautotrophicus (336 aa) FASTA scores: opt: 587, E(): 1.8e-29, (34.9% identity in 315 aa overlap); Q9X5W0|GRSE TDP-GLUCOSE-4,6-DEHYDRATASE HOMOLOG from Streptomyces griseus (324 aa), FASTA scores: opt: 583, E(): 3.2e-29, (35.7% identity in 325 aa overlap); Q9K7J7|SPSJ|BH3364 SPORE COAT POLYSACCHARIDE SYNTHESIS (DTDP GLUCOSE 4, 6-DEHYDRATASE) from Bacillus halodurans (321 aa), FASTA scores: opt: 562, E(): 6.5e-28, (33.0% identity in 318 aa overlap); Q9UZH2|RFBB|PAB0785 DTDP-GLUCOSE 4,6-DEHYDRATASE from Pyrococcus abyssi (333 aa), FASTA scores: opt: 552, E(): 2.8e-27, (33.95% identity in 318 aa overlap); P27830|RFFG_ECOLI|B3788 DTDP-GLUCOSE 4,6-DEHYDRATASE from Escherichia coli strain K12 (355 aa), FASTA scores: opt: 401, E(): 7.5e-28, (31.3% identity in 348 aa overlap); etc. But also similar to several UDP-glucose 4-epimerases (EC 5.1.3.2) and other proteins e.g. O59375|PH1742 LONG HYPOTHETICAL UDP-GLUCOSE 4-EPIMERASE from Pyrococcus horikoshii (306 aa) FASTA scores: opt: 600, E(): 2.6e-30, (34.5% identity in 313 aa overlap); Q9ZGC7|LANH14 NDP-HEXOSE 4,6-DEHYDRATASE HOMOLOGfrom Streptomyces cyanogenus (326 aa), FASTA scores: opt: 593, E(): 7.6e-30, (36.45% identity in 321 aa overlap); Q57664|GALE_METJA|MJ0211 PUTATIVE UDP-GLUCOSE 4-EPIMERASE from Methanococcus jannaschii (305 aa) FASTA scores: opt: 575, E(): 9.6e-29, (32.6% identity in 313 aa overlap); etc. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY, DTDP-GLUCOSE DEHYDRATASE SUBFAMILY. Note that previously known as epiB.; epiB; dTDP-glucose 4,6-dehydratase	4230256..4231236	Mycobacterium tuberculosis H37Rv	886117
NP_218302.1	CDS	Rv3785	NC_000962.2	4231320	4232393	D	Rv3785, (MTCY13D12.19), len: 357 aa. Hypothetical unknown protein. Note that this putative protein is equivalent to AAK48258|MT3893 NAD-DEPENDENT EPIMERASE/DEHYDRATASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (712 aa), but shorter 355 aa.; hypothetical protein	4231320..4232393	Mycobacterium tuberculosis H37Rv	886119
NP_218303.1	CDS	Rv3786c	NC_000962.2	4232374	4233597	R	Rv3786c, (MTCY13D12.20), len: 407 aa. Hypothetical unknown protein. Segment between aa 265-300 (approximatively) is highly similar to part of O03937|RORF1608 MINOR CAPSID PROTEIN from Bacteriophage phig1e (1608 aa), FASTA scores: opt: 242, E(): 8.4e-07, (26.85% identity in 272 aa overlap); Q9ETT9|ORF36 PUTATIVE PEPTIDASE from Corynebacterium equii (Rhodococcus equi) plasmid pREAT701 (p33701) and Plasmid virulence (546 aa), FASTA scores: opt: 231, E(): 1.6e-06, (34.15% identity in 167 aa overlap); O69910|SC2E1.40c HYPOTHETICAL 22.8 KDA PROTEIN. from Streptomyces coelicolor (226 aa) FASTA scores: opt: 218, E(): 4.6e-06, (34.15% identity in 164 aa overlap); and others.; hypothetical protein	complement(4232374..4233597)	Mycobacterium tuberculosis H37Rv	886108
NP_218304.1	CDS	Rv3787c	NC_000962.2	4233610	4234536	R	Rv3787c, (MTCY13D12.21), len: 308 aa. Conserved hypothetical protein, highly similar to several mycobacterial hypothetical proteins e.g. P95074|Rv0726c|MTCY210.45c from Mycobacterium tuberculosis (367 aa), FASTA scores: opt: 1038, E(): 1.6e-58, (55.85% identity in 283 aa overlap); O53795|MBE50c|Rv0731c|MTV041.05c from Mycobacterium tuberculosis (318 aa), FASTA scores: opt: 1030, E(): 4.5e-58, (56.15% identity in 292 aa overlap); Q9CCZ4|ML2640 from Mycobacterium leprae (310 aa) FASTA scores: opt: 709, E(): 9.9e-38, (43.75% identity in 279 aa overlap); etc.; hypothetical protein	complement(4233610..4234536)	Mycobacterium tuberculosis H37Rv	886118
NP_218305.1	CDS	Rv3788	NC_000962.2	4234780	4235265	D	Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator	4234780..4235265	Mycobacterium tuberculosis H37Rv	886120
NP_218306.1	CDS	Rv3789	NC_000962.2	4235374	4235739	D	Rv3789, (MTCY13D12.23), len: 121 aa. Possible conserved integral membrane protein, equivalent to Q9CDA3|ML0110 HYPOTHETICAL 13.9 KDA PROTEIN from Mycobacterium leprae (123 aa) FASTA scores: opt: 587, E(): 7.3e-34, (72.95% identity in 122 aa overlap). Also equivalent to AAK48262 from Mycobacterium tuberculosis strain CDC1551 (142 aa) but shorter 21 aa.; integral membrane protein	4235374..4235739	Mycobacterium tuberculosis H37Rv	886109
NP_218307.1	CDS	Rv3790	NC_000962.2	4235779	4237164	D	Rv3790, (MTCY13D12.24), len: 461 aa. Probable oxidoreductase (EC 1.-.-.-), equivalent to Q9CDA4|ML0109 PUTATIVE FAD-LINKED OXIDOREDUCTASE from Mycobacterium leprae (460 aa), FASTA scores: opt: 2722, E(): 1.4e-161, (86.55% identity in 461 aa overlap). Also highly similar to others e.g. Q9KZA4|SC5G8.10c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (457 aa), FASTA scores: opt: 1336, E(): 1.7e-75, (47.1% identity in 452 aa overlap); Q98KY4|MLL1265 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (449 aa), FASTA scores: opt: 636, E(): 4.9e-32, (36.0% identity in 439 aa overlap); Q9HDX8|SPAPB1A10.12c PUTATIVE D-ARABINONO-1,4-LACTONE OXIDASE from Schizosaccharomyces pombe (Fission yeast) (461 aa), FASTA scores: opt: 297, E(): 5.6e-11, (23.55% identity in 467 aa overlap); etc. C-terminal end has a high similarity to Q9AQD0 PUTATIVE OXIDOREDUCTASE (FRAGMENT) from Mycobacterium smegmatis (149 aa) FASTA scores: opt: 901, E(): 6.5e-49, (86.6% identity in 149 aa overlap).; oxidoreductase	4235779..4237164	Mycobacterium tuberculosis H37Rv	886125
NP_218308.1	CDS	Rv3791	NC_000962.2	4237165	4237929	D	Rv3791, (MTCY13D12.25), len: 254 aa. Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), equivalent to Q9CDA5|ML0108 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (254 aa), FASTA scores: opt: 1458, E(): 1.6e-83, (89.0% identity in 254 aa overlap); and O05764 PUTATIVE PROTEIN BELONGING TO THE SHORT-CHAIN ALCOHOL DEHYDROGENASE from Mycobacterium smegmatis (254 aa), FASTA scores: opt: 1412, E(): 1.2e-80, (85.05% identity in 254 aa overlap). Also highly similar to Q9KZA5|SC5G8.09c PUTATIVE SHORT-CHAIN DEHYDROGENASE from Streptomyces coelicolor (256 aa), FASTA scores: opt: 733, E(): 1.8e-38, (45.3% identity in 254 aa overlap); and P43168|YMP3_STRCO HYPOTHETICAL OXIDOREDUCTASE from Streptomyces coelicolor (251 aa), FASTA scores: opt: 623, E(): 1.2e-31, (42.15% identity in 254 aa overlap); and similar to various oxidoreductases (principally acetoacetyl-CoA reductases) e.g. P14697|PHBB_ALCEU ACETOACETYL-CoA REDUCTASE (EC 1.1.1.36) (246 aa) from Alcaligenes eutrophus (Ralstonia eutropha) (246 aa) FASTA scores: opt: 264, E(): 2.3e-09, (29.9% identity in 204 aa overlap); P45375|PHBB_CHRVI ACETOACETYL-CoA REDUCTASE from Chromatium vinosum (246 aa), FASTA scores: opt: 261, E(): 3.5e-09, (27.45% identity in 226 aa overlap); Q9RT30|DR1938 OXIDOREDUCTASE (SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY) from Deinococcus radiodurans (283 aa), FASTA scores: opt: 251, E(): 1.7e-08, (27.55% identity in 236 aa overlap); etc. Also similar to Q10681|YK73_MYCTU|Rv2073c|MT2133|MTCY49.12 PUTATIVE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE from Mycobacterium tuberculosis (249 aa), FASTA scores: opt: 589, E(): 1.5e-29, (41.25% identity in 252 aa overlap). Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.; short chain dehydrogenase	4237165..4237929	Mycobacterium tuberculosis H37Rv	886124
NP_218309.1	CDS	Rv3792	NC_000962.2	4237932	4239863	D	Rv3792, (MTCY13D12.26), len: 643 aa. Probable conserved transmembrane protein, equivalent, but longer 21 aa, to Q9CDA6|ML0107 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (632 aa), FASTA scores: opt: 1981, E(): 2.1e-110, (77.5% identity in 631 aa overlap). C-terminal end highly similar to C-terminus of O05765 PUTATIVE PRODUCT ORF 3 from Mycobacterium smegmatis (603 aa), FASTA scores: opt: 1261, E(): 1.4e-67, (70.7% identity in 266 aa overlap).; transmembrane protein	4237932..4239863	Mycobacterium tuberculosis H37Rv	886127
NP_218310.1	CDS	embC	NC_000962.2	4239863	4243147	D	Rv3793, (MTCY13D12.27), len: 1094 aa. embC, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below), equivalent to Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1070 aa) FASTA scores: opt: 6078,E(): 0, (82.95% identity in 1072 aa overlap); Q50393|EMBC PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1074 aa), FASTA scores: opt: 5523, E(): 0, (75.35% identity in 1072 aa overlap). Also similar to Q9CDA9|EMBB| ML0104 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1083 aa), FASTA scores: opt: 2789, E(): 1.9e-156, (44.0% identity in 1095 aa overlap); O30406|EMBB PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1082 aa), FASTA scores: opt: 2746, E(): 6.4e-154, (44.6% identity in 1096 aa overlap); etc. Also similar to to P72030|EMBB|Rv3795|MTCY13D12.29 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1098 aa), FASTA scores: opt: 2276, E(): 3.1e-126, (44.45% identity in 1118 aa overlap); and P72060|EMBA|Rv3794|MTCY13D12.28 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 1974, E(): 1.9e-108, (41.0% identity in 1110 aa overlap). Contains PS00044 Bacterial regulatory proteins, lysR family signature; and PS00017 ATP/GTP-binding site motif A (P-loop).; integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase)	4239863..4243147	Mycobacterium tuberculosis H37Rv	886112
NP_218311.1	CDS	embA	NC_000962.2	4243233	4246517	D	Rv3794, (MTCY13D12.28), len: 1094 aa. embA, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below), equivalent to P71485|EMBA ARABINOSYL TRANSFERASE from Mycobacterium avium (1108 aa), FASTA scores: opt: 5024, E(): 0, (81.9% identity in 1109 aa overlap); Q9CDA8|EMBA|ML0105 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1111 aa), FASTA scores: opt: 4782, E(): 0, (78.6% identity in 1111 aa overlap); Q50394|EMBA PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1092 aa), FASTA scores: opt: 4100, E(): 0, (67.4% identity in 1092 aa overlap). Also similar to Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1070 aa), FASTA scores: opt: 1933, E(): 1.5e-100, (40.6% identity in 1108 aa overlap); Q50393|EMBC PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1074 aa), FASTA scores: opt: 1870, E(): 5.1e-97, (41.4% identity in 1113 aa overlap); etc. Also similar to P72059|EMBC|Rv3793|MTCY13D12.27 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 1974, E(): 7.7e-103, (40.9% identity in 1110 aa overlap); and P72030|EMBB|Rv3795|MTCY13D12.29 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1098 aa), FASTA scores: opt: 1288, E(): 2.1e-64, (42.5% identity in 1114 aa overlap). Supposed regulated by embR|Rv1267c.; integral membrane indolylacetylinositol arabinosyltransferase EMBA (arabinosylindolylacetylinositol synthase)	4243233..4246517	Mycobacterium tuberculosis H37Rv	886123
NP_218312.1	CDS	embB	NC_000962.2	4246514	4249810	D	Rv3795, (MTCY13D12.29), len: 1098 aa. embB, integral membrane protein, indolylacetylinositol arabinosyltransferase (EC 2.4.2.34) (see citations below), equivalent to P71486|EMBB ARABINOSYL TRANSFERASE from Mycobacterium avium (1065 aa), FASTA scores: opt: 4998, E(): 0, (83.25% identity in 1076 aa overlap); Q9CDA9|EMBB|ML0104 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1083 aa), FASTA scores: opt: 4706, E(): 0, (78.0% identity in 1101 aa overlap); O30406|EMBB (alias Q50395) PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1082 aa), FASTA scores: opt: 4163, E(): 0, (68.4% identity in 1091 aa overlap); etc. Also similar to Q50393|EMBC PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium smegmatis (1074 aa), FASTA scores: opt: 2482, E(): 5e-135, (44.7% identity in 1101 aa overlap); Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL TRANSFERASE from Mycobacterium leprae (1070 aa), FASTA scores: opt: 2259, E(): 3.4e-122, (43.4% identity in 1104 aa overlap); etc. Also similar to P72059|EMBC|Rv3793|MTCY13D12.27 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 2276, E(): 3.6e-123, (44.45% identity in 1118 aa overlap); and P72060|EMBA|Rv3794|MTCY13D12.28 INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis (1094 aa), FASTA scores: opt: 1288, E(): 2.5e-66, (42.35% identity in 1114 aa overlap). Supposed regulated by embR|Rv1267c.; integral membrane indolylacetylinositol arabinosyltransferase EMBB (arabinosylindolylacetylinositol synthase)	4246514..4249810	Mycobacterium tuberculosis H37Rv	886126
YP_178016.1	CDS	Rv3796	NC_000962.2	4249878	4251005	D	Rv3796, (MTV026.01-MTCY13D12.30), len: 375 aa. Conserved hypothetical protein. C-terminal end similar in part to Q983J3|MLR8305 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (227 aa), FASTA scores: opt: 288, E(): 4e-09, (38.95% identity in 154 aa overlap). Similar to P54548|YQJK_BACSU HYPOTHETICAL PROTEIN (BELONGS TO THE ATSA/ELAC FAMILY) from Bacillus subtilis (307 aa) FASTA scores: opt: 263, E(): 1.3e-07, (26.1% identity in 295 aa overlap); and some similarity to other proteins e.g. AAK46775|MT2479 PUTATIVE ARYLSULFATASE from Mycobacterium tuberculosis strain CDC1551 (224 aa), FASTA scores: opt: 194, E(): 0.00072, (25.85% identity in 259 aa overlap). Equivalent to AAK48269 from Mycobacterium tuberculosis strain CDC1551 (338 aa) but longer 37 aa. SOME SIMILARITY TO THE A. CARRAGEENOVORA ATSA / E. COLI ELAC FAMILY. Note that previously known as atsH.; atsH; hypothetical protein	4249878..4251005	Mycobacterium tuberculosis H37Rv	886128
NP_218314.1	CDS	fadE35	NC_000962.2	4251085	4252866	D	Rv3797, (MTV026.02), len: 593 aa. Probable fadE35, acyl-CoA dehydrogenase (EC 1.3.99.-), similar to many e.g. Q9HY33|PA3593 from Pseudomonas aeruginosa (575 aa) FASTA scores: opt: 838, E(): 2.1e-46, (35.3% identity in 569 aa overlap); Q9ANZ8|AIDB from Burkholderia pseudomallei (Pseudomonas pseudomallei) (554 aa), FASTA scores: opt: 633, E(): 3.4e-33, (33.1% identity in 480 aa overlap); Q9HX44|PA3972 from Pseudomonas aeruginosa (549 aa) FASTA scores: opt: 560, E(): 1.7e-28, (29.9% identity in 569 aa overlap); P33224|AIDB_ECOLI|B4187 from Escherichia coli strain K12 (541 aa), FASTA scores: opt: 455, E(): 1e-21, (31.15% identity in 514 aa overlap); etc. Also similar to O86368|FADE8|Rv0672|MTCI376.02c ACYL-CoA DEHYDROGENASE from Mycobacterium tuberculosis (542 aa), FASTA scores: opt: 479, E(): 2.9e-23, (32.2% identity in 460 aa overlap). COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY.; acyl-CoA dehydrogenase FADE35	4251085..4252866	Mycobacterium tuberculosis H37Rv	886122
NP_218315.1	CDS	Rv3798	NC_000962.2	4252993	4254327	D	Rv3798, (MTV026.03), len: 444 aa. Probable transposase for insertion sequence element IS1557, highly similar to Q60255 SIMILAR TO TRANSPOSASE OF ISAE1 FROM ALCALIGENES EUTROPHUS H1-4 (FRAGMENT) from dibenzofuran-degrading bacterium DPO360 (163 aa) FASTA scores: opt: 767, E(): 3.2e-42, (67.25% identity in 168 aa overlap); and similar to P74920 TRANSPOSASE from Thiobacillus ferrooxidans (404 aa), FASTA scores: opt: 375, E(): 1.1e-16, (27.55% identity in 439 aa overlap); Q48349 TRANSPOSASE from Alcaligenes eutrophus (Ralstonia eutropha) (408 aa), FASTA scores: opt: 324, E(): 2e-13, (3.9% identity in 369 aa overlap); Q9FDC1|TNP TRANSPOSASE from Burkholderia mallei (Pseudomonas mallei) (386 aa) FASTA scores: opt: 282, E(): 9.8e-11, (25.85% identity in 391 aa overlap); etc. C-terminal end identical to O53804|Rv0741|MTV041.15 TRANSPOSASE from Mycobacterium tuberculosis (104 aa), FASTA scores: opt: 582, E(): 1.8e-30, (85.6% identity in 104 aa overlap). BELONGS TO THE TRANSPOSASE FAMILY 12.; transposase	4252993..4254327	Mycobacterium tuberculosis H37Rv	886268
NP_218316.2	CDS	accD4	NC_000962.2	4254380	4255948	R	Rv3799c, (MTV026.04c), len: 522 aa. Probable accD4, propyonyl-CoA carboxylase beta chain 4 (EC 6.4.1.3), equivalent to Q9CDB0|ACCD4|ML0102 PUTATIVE ACYL COA CARBOXYLASE from Mycobacterium leprae (517 aa) FASTA scores: opt: 3154, E(): 8e-187, (91.2% identity in 511 aa overlap) . Also similar to many e.g. Q9X4K7|PCCB from Streptomyces coelicolor (530 aa), FASTA scores: opt: 1714, E(): 4.4e-98, (50.0% identity in 510 aa overlap); P53003|PCCB_SACER from Saccharopolyspora erythraea (Streptomyces erythraeus) (546 aa), FASTA scores: opt: 1549, E(): 6.6e-88, (50.65% identity in 519 aa overlap); Q9WZH5|TM0716 from Thermotoga maritima (515 aa) FASTA scores: opt: 1529, E(): 1.1e-86, (46.7% identity in 512 aa overlap); etc. Also similar to P53002|PCCB_MYCLE|ACCD5|PCCB|ML0731|B1308_C1_125 PROBABLE PROPIONYL-CoA CARBOXYLASE BETA CHAIN 5 from Mycobacterium leprae (549 aa), FASTA scores: opt: 1493, E(): 1.9e-84, (49.8% identity in 514 aa overlap); and P96885|PCC5_MYCTU|ACCD5|PCCB|Rv3280|MT3379.1|MTCY71.20 PROBABLE PROPIONYL-CoA CARBOXYLASE BETA CHAIN 5 from Mycobacterium tuberculosis (548 aa), FASTA scores: opt: 1471, E(): 4.2e-83, (49.15% identity in 515 aa overlap). BELONGS TO THE ACCD/PCCB FAMILY. Length extended since first submission (+5 aa).; propionyl-CoA carboxylase beta chain	complement(4254380..4255948)	Mycobacterium tuberculosis H37Rv	886131
NP_218317.1	CDS	pks13	NC_000962.2	4255945	4261146	R	Rv3800c, (MTV026.05c), len: 1733 aa. Probable pks13, polyketide synthase (EC undetermined), equivalent to Q9CDB1|PKS13|ML0101 POLYKETIDE SYNTHASE from Mycobacterium leprae (1784 aa), FASTA scores: opt: 7454, E(): 0, (83.6% identity in 1748 aa overlap); and similar to Q9Z5K6|ML2357|MLCB12.02c PUTATIVE POLYKETIDE SYNTHASE from Mycobacterium leprae (1871 aa), FASTA scores: opt: 1682, E(): 1.2e-85, (38.3% identity in 1096 aa overlap). Also similar in part to many e.g. Q9ADL6|SORA SORAPHEN POLYKETIDE SYNTHASE A from Polyangium cellulosum (6315 aa) FASTA scores: opt: 1422, E(): 1e-70, (31.45% identity in 1616 aa overlap); AAK73501|AMPHI AMPHI PROTEIN (involved in amphotericin biosynthesis) from Streptomyces nodosus (9510 aa), FASTA scores: opt: 1441, E(): 1.2e-71, (30.45% identity in 1662 aa overlap); Q9RFL0|MTAB MTAB PROTEIN (involved in myxothiazol biosynthesis) from Stigmatella aurantiaca (4003 aa), FASTA scores: opt: 1429, E(): 2.8e-71, (33.8% identity in 1089 aa overlap); Q9L4X2|NYSJ from Streptomyces noursei (5435 aa), FASTA scores: opt: 1407, E(): 6.1e-70, (30.5% identity in 1764 aa overlap); CAC37876|SC1G7.01c from Streptomyces coelicolor (3489 aa) FASTA scores: opt: 1382, E(): 1e-68, (31.05% identity in 1489 aa overlap); etc. Also highly similar to Q10977|PPSA_MYCTU|Rv2931|MT3000|MTCY338.20 PHENOLPTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE from Mycobacterium tuberculosis (1876 aa), FASTA scores: opt: 1728, E(): 3.4e-88, (36.95% identity in 1269 aa overlap); and P96203|PPSD|Rv2934|MTCY19H9.02. Contains PS00606 Beta-ketoacyl synthases active site.; polyketide synthase PKS13	complement(4255945..4261146)	Mycobacterium tuberculosis H37Rv	886133
NP_218318.1	CDS	fadD32	NC_000962.2	4261153	4263066	R	activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase	complement(4261153..4263066)	Mycobacterium tuberculosis H37Rv	886130
NP_218319.1	CDS	Rv3802c	NC_000962.2	4263355	4264365	R	Rv3802c, (MTV026.07c), len: 336 aa. Probable conserved membrane protein, with a N-terminal signal sequence followed by Pro-rich region. Equivalent to Q9CDB3|ML0099 HYPOTHETICAL PROTEIN from Mycobacterium leprae (336 aa) FASTA scores: opt: 1759, E(): 1.1e-85, (75.5% identity in 335 aa overlap).; hypothetical protein	complement(4263355..4264365)	Mycobacterium tuberculosis H37Rv	886135
YP_178017.1	CDS	fbpD	NC_000962.2	4264563	4265462	R	Rv3803c, (MT3910, MTV026.08c), len: 299 aa. fbpD (alternate gene names: mpt51, mpb51, fbpC1), secreted MPB51/MPT51 antigen protein (fibronectin-binding protein C) (mycolyl transferase 85C) (EC 2.3.1.-) (see citations below), identical to Q48923|MPT51|MPB51 ANTIGEN PRECURSOR from Mycobacterium bovis (299 aa), FASTA scores: opt: 2093, E(): 1.5e-112, (100.0% identity in 299 aa overlap) (see Ohara et al., 1995); and highly similar to other Mycobacterial antigen precursors e.g. Q05868|MPT5_MYCLE|MPT51|ML0098 MPT51 ANTIGEN PRECURSOR from Mycobacterium leprae (301 aa), FASTA scores: opt: 1624, E(): 9.8e-86, (77.8% identity in 302 aa overlap); O52972|A85C_MYCAV|FBPC ANTIGEN 85-C PRECURSOR (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium avium (352 aa), FASTA scores: opt: 753, E(): 6.6e-36, (41.5% identity in 315 aa overlap); P21160|A85B_MYCKA ANTIGEN 85-B PRECURSOR (FIBRONECTIN-BINDING PROTEIN B) from Mycobacterium kansasii (325 aa), FASTA scores: opt: 574, E(): 1.1e-25, (37.55% identity in 309 aa overlap); P12942|A85B_MYCBO ANTIGEN 85-B PRECURSOR from Mycobacterium bovis (323 aa), FASTA scores: opt: 572, E(): 1.4e-25, (39.85% identity in 291 aa overlap); etc. Also similar to P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|FBPC2 SECRETED ANTIGEN 85-C (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 751, E(): 8.4e-36, (40.65% identity in 310 aa overlap); P17944|A85A_MYCTU|FBPA|MPT44|Rv3804c|MT3911|MTV026.09c SECRETED ANTIGEN 85-A (MYCOLYL TRANSFERASE 85A) (FIBRONECTIN-BINDING PROTEIN A) from Mycobacterium tuberculosis (338 aa), FASTA scores: opt: 592, E(): 1e-26, (39.05% identity in 302 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Note that the secreted protein MPB51 is one of the major proteins in the culture filtrate of Mycobacterium bovis BCG.; mpt51; mpb51; fbpC1; secreted MPT51/MPB51 antigen protein FBPD (MPT51/MPB51 antigen 85 complex C) (AG58C) (Mycolyl transferase 85C) (fibronectin-binding protein C) (85C)	complement(4264563..4265462)	Mycobacterium tuberculosis H37Rv	886121
NP_218321.1	CDS	fbpA	NC_000962.2	4265642	4266658	R	Rv3804c, (MT3911, MTV026.09c), len: 338 aa. fbpA (alternate gene names: mpt44, 85A), precursor of the 85-A antigen (fibronectin-binding protein A) (mycolyl transferase 85A) (EC 2.3.1.-) (see citations below), identical to P17944|P17996|FBPA|MPT44 ANTIGEN 85-A PRECURSOR from Mycobacterium bovis (338 aa), FASTA scores: opt: 2341, E(): 1.2e-132, (100.0% identity in 338 aa overlap); and highly similar to other Mycobacterial antigen precursors e.g. O52956|A85A_MYCAV|FBPA ANTIGEN 85-A PRECURSOR (85A) from Mycobacterium avium (347 aa), FASTA scores: opt: 1987, E(): 1.7e-111, (82.55% identity in 338 aa overlap); Q05861|A85A_MYCLE|FBPA|ML0097 ANTIGEN 85-A PRECURSOR (85A) from Mycobacterium leprae (330 aa), FASTA scores: opt: 1936, E(): 1.9e-108, (83.0% identity in 329 aa overlap); O06052|A85A_MYCGO|FBPA ANTIGEN 85-A PRECURSOR (85A) from Mycobacterium gordonae (339 aa), FASTA scores: opt: 1932, E(): 3.3e-108, (80.45% identity in 338 aa overlap); etc. Also highly similar to P31952|A85B_MYCTU|FBPB|Rv1886c|MT1934|MTCY180.32 SECRETED ANTIGEN 85-B from Mycobacterium tuberculosis (325 aa), FASTA scores: opt: 1830, E(): 3.9e-102, (78.85% identity in 317 aa overlap); P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|FBPC2 SECRETED ANTIGEN 85-C from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 1597, E(): 3.4e-88, (67.25% identity in 336 aa overlap).; mpt44; 85A; secreted antigen 85-A FBPA (Mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A)	complement(4265642..4266658)	Mycobacterium tuberculosis H37Rv	886132
NP_218322.1	CDS	Rv3805c	NC_000962.2	4266953	4268836	R	Rv3805c, (MTV026.10c), len: 627 aa. Probable conserved transmembrane protein, equivalent, but shorter 19 aa, to Q9CDB4|ML0096 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (649 aa), FASTA scores: opt: 3511, E(): 1.1e-204, (80.9% identity in 629 aa overlap). Equivalent to AAK48278 from Mycobacterium tuberculosis strain CDC1551 (641 aa) but shorter 14 aa.; transmembrane protein	complement(4266953..4268836)	Mycobacterium tuberculosis H37Rv	886138
NP_218323.1	CDS	Rv3806c	NC_000962.2	4268925	4269833	R	catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase	complement(4268925..4269833)	Mycobacterium tuberculosis H37Rv	886129
NP_218324.1	CDS	Rv3807c	NC_000962.2	4269840	4270337	R	Rv3807c, (MTV026.12), len: 165 aa. Possible conserved transmembrane protein, equivalent to Q9CDB6|ML0094 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (192 aa), FASTA scores: opt: 714, E(): 2.4e-38, (72.85% identity in 151 aa overlap). Also highly similar to Q9KZA3|SC5G8.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (169 aa), FASTA scores: opt: 324, E(): 1.1e-13, (41.5% identity in 159 aa overlap); and similar in part to others e.g. Q9K3L3|SCG20A.27 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (230 aa), FASTA scores: opt: 277, E(): 1.3e-10, (41.65% identity in 168 aa overlap); P72269|ORF8 HYPOTHETICAL PROTEIN from Rhodococcus erythropolis (487 aa) FASTA scores: opt: 229, E(): 2.7e-07, (36.25% identity in 149 aa overlap); O86625|SC3A7.24c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (201 aa) FASTA scores: opt: 200, E(): 9.1e-06, (34.95% identity in 146 aa overlap); Q9KYD7|SCD72A.19 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (238 aa) FASTA scores: opt: 178, E(): 0.00026, (35.7% identity in 112 aa overlap); etc.; transmembrane protein	complement(4269840..4270337)	Mycobacterium tuberculosis H37Rv	886134
NP_218325.1	CDS	glfT	NC_000962.2	4270366	4272279	R	Rv3808c, (MTV026.13c), len: 637 aa. glfT, bifunctional UDP-galactofuranosyl transferase (EC 2.-.-.-) (see citations below). Equivalent to Q9CDB7|ML0093 HYPOTHETICAL PROTEIN from Mycobacterium leprae (643 aa), FASTA scores: opt: 3751, E(): 0, (85.4% identity in 643 aa overlap). Contains a beta-glycosyltransferase domain A.; bifunctional UDP-galactofuranosyl transferase GLFT	complement(4270366..4272279)	Mycobacterium tuberculosis H37Rv	886136
NP_218326.1	CDS	glf	NC_000962.2	4272276	4273475	R	Rv3809c, (MTV026.14), len: 399 aa. glf (alternate gene name: ceoA), UDP-galactopyranose mutase (EC 5.4.99.9) (see citations below), identical to previously sequenced gene, and equivalent to Q9CDB8|GLF|ML0092 PUTATIVE UDP-GALACTOPYRANOSE MUTASE from Mycobacterium leprae (413 aa), FASTA scores: opt: 2347, E(): 1.3e-140, (86.6% identity in 396 aa overlap). Also highly similar to others e.g. AAK61905|EPSJ UDP-GALACTOPYRANOSE MUTASE (PROTEIN INVOLVED IN EXOPOLYSACCHARIDES BIOSYNTHESIS) from Streptococcus thermophilus (365 aa), FASTA scores: opt: 972, E(): 5.9e-54, (45.85% identity in 375 aa overlap); P37747|GLF_ECOLI|B2036 UDP-GALACTOPYRANOSE MUTASE from Escherichia coli strain K12 (367 aa), FASTA scores: opt: 958, E(): 4.5e-53, (43.55% identity in 379 aa overlap); O86897|CAP33FN from Streptococcus pneumoniae (369 aa) FASTA scores: opt: 954, E(): 8.1e-53, (44.8% identity in 375 aa overlap); etc. COFACTOR: FAD (BY SIMILARITY). N-TERMINAL SHOWS SIMILARITY TO FAD OR NAD CONTAINING PROTEINS.; ceoA; UDP-galactopyranose mutase Glf	complement(4272276..4273475)	Mycobacterium tuberculosis H37Rv	886142
NP_218327.1	CDS	pirG	NC_000962.2	4273739	4274593	D	Rv3810, (MTV026.15), len: 284 aa. pirG (alternate gene names: P36 or erp for Exported Repeated Protein), cell surface protein precursor (see citations below), equivalent to P19361|28KD_MYCLE|ML0091 28 KDA ANTIGEN PRECURSOR from Mycobacterium leprae (236 aa), FASTA scores: opt: 555, E(): 9.8e-18, (52.65% identity in 281 aa overlap).; erp; P36; exported repetitive protein precursor PirG (cell surface protein) (EXP53)	4273739..4274593	Mycobacterium tuberculosis H37Rv	886139
YP_178018.1	CDS	Rv3811	NC_000962.2	4274798	4276417	D	Rv3811, (MTV026.16), len: 539 aa. Conserved hypothetical protein, showing some similarity to Q9KZK5|SCE34.21c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (416 aa), FASTA scores: opt: 603, E(): 8.1e-26, (34.4% identity in 404 aa overlap); Q9S2P9|SC5F7.14c HYPOTHETICAL 31.9 KDA PROTEIN from Streptomyces coelicolor (308 aa), FASTA scores: opt: 472, E(): 9.5e-19, (37.5% identity in 208 aa overlap). Middle section (approximatively aa 185-350/390) shows some similarity with Q9GK12 PEPTIDOGLYCAN RECOGNITION PROTEIN PRECURSOR from Camelus dromedarius (Dromedary) (Arabian camel) (193 aa) FASTA scores: opt: 274, E(): 4.6e-08, (32.2% identity in 177 aa overlap); O75594|PGLYRP|PGRP from Homo sapiens (Human) (196 aa), FASTA scores: opt: 272, E(): 6e-08, (30.9% identity in 220 aa overlap); Q9JLN4|PGRP PEPTIDOGLYCAN RECOGNITION PROTEIN from Rattus norvegicus (Rat) (182 aa), FASTA scores: opt: 253, E(): 6.2e-07, (32.15% identity in 171 aa overlap); etc. C-terminal end shows similarity with Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (ONE OF THE TWO MAJOR SECRETED PROTEINS) from Corynebacterium glutamicum (Brevibacterium flavum) (657 aa), FASTA scores: opt: 250, E(): 2.7e-06, (39.45% identity in 109 aa overlap). Contains PS00687 Aldehydedehydrogenases glutamic acid active site. Note that previously known as csp.; csp; hypothetical protein	4274798..4276417	Mycobacterium tuberculosis H37Rv	886137
YP_178019.1	CDS	PE_PGRS62	NC_000962.2	4276571	4278085	D	Rv3812, (MTV026.17, MTCY409.18c), len: 540 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citations below), similar to many e.g. P96828|Rv0151c|MTCI5.25c (588 aa), FASTA scores: opt: 389, E(): 6.2e-14, (29.2% identity in 473 aa overlap); MTCY7H7B_27; MTCY493_24; MTCY441_4; MTCY39_36; MTCY1A11_4; MTCY359_33; MTCY130_10; MTCY98_9; etc. The transcription of this CDS seems to be activated in macrophages (see Ramakrishnan et al., 2000).; PE-PGRS family protein	4276571..4278085	Mycobacterium tuberculosis H37Rv	886143
NP_218330.1	CDS	Rv3813c	NC_000962.2	4278394	4279215	R	Rv3813c, (MTCY409.17), len: 273 aa. Conserved hypothetical protein, equivalent to Q9CDB9|ML0089 HYPOTHETICAL PROTEIN from Mycobacterium leprae (281 aa) FASTA scores: opt: 1479, E(): 9.6e-81, (80.45% identity in 271 aa overlap); and similar to Q98LI0|MLL1014 from (280 aa) . Also similar to many hypothetical proteins from several organisms e.g. Q9ZBX2|SCD78.27c from Streptomyces coelicolor (280 aa), FASTA scores: opt: 597, E(): 2.2e-28, (43.25% identity in 266 aa overlap); Q9RXR7|DR0240 from Deinococcus radiodurans (284 aa), FASTA scores: opt: 543, E(): 3.5e-25, (38.65% identity in 264 aa overlap); Q99YH5|SPY1700 from Streptococcus pyogenes (274 aa) FASTA scores: opt: 373, E(): 4.3e-15, (30.75% identity in 270 aa overlap); P70947|YITU from Bacillus subtilis (270 aa) FASTA scores: opt: 353, E(): 6.5e-14, (30.0% identity in 280 aa overlap); etc.; hypothetical protein	complement(4278394..4279215)	Mycobacterium tuberculosis H37Rv	886147
NP_218331.1	CDS	Rv3814c	NC_000962.2	4279230	4280015	R	Rv3814c, (MTCY409.16), len: 261 aa. Possible acyltransferase (EC 2.3.1.-), highly similar to Q9CDC0|ML0087 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (257 aa), FASTA scores: opt: 753, E(): 7.7e-42, (46.75% identity in 246 aa overlap). Also highly similar to many acyltransferases and hypothetical proteins e.g. Q9K3R3|2SCG4.01 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (242 aa), FASTA scores: opt: 587, E(): 4.6e-31, (41.95% identity in 243 aa overlap); Q9ZBS1|SC7A1.02 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (264 aa), FASTA scores: opt: 293, E(): 6.6e-12, (29.2% identity in 267 aa overlap); Q9PNZ5|AAS|CJ0938 PUTATIVE 2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE / ACYL-ACYL CARRIER PROTEIN SYNTHETASE from Campylobacter jejuni (1170 aa), FASTA scores: opt: 274, E(): 3.9e-10, (29.1% identity in 219 aa overlap) (similarity only with middle section); Q9EY25 PUTATIVE ACETYL TRANSFERASE from Xanthomonas oryzae pv. oryzae (249 aa), FASTA scores: opt: 238, E(): 2.4e-08, (29.2% identity in 209 aa overlap); etc. Also highly similar to downstream ORFs O07808|Rv3815c|MTCY409.15 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (251 aa), FASTA scores: opt: 1069, E(): 2.1e-62, (60.4% identity in 245 aa overlap); and O07807|Rv3816c|MTCY409.14 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (259 aa), FASTA scores: opt: 776, E(): 2.5e-43, (50.9% identity in 228 aa overlap). And similar to O53516|Rv2182c|MTV021.15c HYPOTHETICAL 27.0 KDA PROTEIN from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 239, E(): 2e-08, (30.6% identity in 232 aa overlap).; acyltransferase	complement(4279230..4280015)	Mycobacterium tuberculosis H37Rv	886150
NP_218332.1	CDS	Rv3815c	NC_000962.2	4280033	4280788	R	Rv3815c, (MTCY409.15), len: 251. Possible acyltransferase (EC 2.3.1.-), highly similar to Q9CDC0|ML0087 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (257 aa), FASTA scores: opt: 845, E(): 2.7e-47, (53.25% identity in 246 aa overlap). Also highly similar to Q9K3R3|2SCG4.01 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (242 aa), FASTA scores: opt: 656, E(): 3.7e-35, (47.85% identity in 234 aa overlap); and similar to many putative acyltransferases and hypothetical proteins e.g. P74498|SLL1848 HYPOTHETICAL 24.3 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (225 aa) FASTA scores: opt: 275, E(): 1.2e-10, (34.8% identity in 181 aa overlap); Q9ZBS1|SC7A1.02 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (264 aa), FASTA scores: opt: 266, E(): 5.2e-10, (29.7% identity in 229 aa overlap); Q9PNZ5|AAS|CJ0938 PUTATIVE 2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE/ ACYL-ACYL CARRIER PROTEIN SYNTHETASE from Campylobacter jejuni (1170 aa), FASTA scores: opt: 264, E(): 2.3e-09, (23.55% identity in 221 aa overlap) (similarity only with middle section); etc. Also highly similar to upstream ORF O07809|Rv3814c|MTCY409.16 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (261 aa), FASTA scores: opt: 1069, E(): 1e-61, (60.4% identity in 245 aa overlap) ; and downstream ORF O07807|Rv3816c|MTCY409.14 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (259 aa) FASTA scores: opt: 847, E(): 2e-47, (55.7% identity in 246 aa overlap). And similar to O53516|Rv2182c|MTV021.15c HYPOTHETICAL 27.0 KDA PROTEIN from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 237, E(): 3.6e-08, (30.9% identity in 233 aa overlap).; acyltransferase	complement(4280033..4280788)	Mycobacterium tuberculosis H37Rv	886149
NP_218333.1	CDS	Rv3816c	NC_000962.2	4280792	4281571	R	Rv3816c, (MTCY409.14), len: 259 aa. Possible acyltransferase (EC 2.3.1.-), equivalent to Q9CDC0|ML0087 PUTATIVE ACYLTRANSFERASE from Mycobacterium leprae (257 aa) FASTA scores: opt: 1401, E(): 1.5e-80, (81.9% identity in 254 aa overlap). Also highly similar to many putative acyltransferases and hypothetical proteins e.g. Q9K3R3|2SCG4.01 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (242 aa), FASTA scores: opt: 758, E(): 2.4e-40, (51.7% identity in 234 aa overlap); Q9ZBS1|SC7A1.02 PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (264 aa), FASTA scores: opt: 312, E(): 2e-12, (29.55% identity in 237 aa overlap); O67841|AAS|AQ_2058 2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE from Aquifex aeolicus (211 aa), FASTA scores: opt: 281, E(): 1.5e-10, (32.7% identity in 162 aa overlap); etc. Also highly similar to upstream ORFs O07808|Rv3815c|MTCY409.15 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (251 aa), FASTA scores: opt: 847, E(): 6.7e-46, (55.7% identity in 246 aa overlap); and O07809|Rv3814c|MTCY409.16 PUTATIVE ACYLTRANSFERASE from Mycobacterium tuberculosis (261 aa), FASTA scores: opt: 776, E(): 1.9e-41, (50.9% identity in 228 aa overlap).; acyltransferase	complement(4280792..4281571)	Mycobacterium tuberculosis H37Rv	886152
NP_218334.1	CDS	Rv3817	NC_000962.2	4281647	4282402	D	Rv3817, (MTCY409.13c), len: 251 aa. Possible phosphotransferase (EC 2.7.-.-), similar to many phosphotransferases e.g. O53023 KANAMYCIN MARKER from Escherichia coli (264 aa), FASTA scores: opt: 232, E(): 7.5e-08, (32.4% identity in 247 aa overlap); BAA78209|NEO NEOMYCINE PHOSPHOTRANSFERASE from Drosophila melanogaster (Fruit fly) (264 aa), FASTA scores: opt: 227, E(): 1.6e-07, (32.0% identity in 247 aa overlap); AAG09774 AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Vibrio cholerae (264 aa), FASTA scores: opt: 227, E(): 1.6e-07, (32.0% identity in 247 aa overlap); P00552|KKA2_KLEPN|NEO|KAN AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Klebsiella pneumoniae (264 aa), FASTA scores: opt: 227, E(): 1.6e-07, (32.0% identity in 247 aa overlap); etc.; phosphotransferase	4281647..4282402	Mycobacterium tuberculosis H37Rv	886144
NP_218335.1	CDS	Rv3818	NC_000962.2	4282449	4283999	D	Rv3818, (MTCY409.12c), len: 516 aa. Hypothetical unknown protein.; hypothetical protein	4282449..4283999	Mycobacterium tuberculosis H37Rv	886153
NP_218336.1	CDS	Rv3819	NC_000962.2	4283996	4284331	D	Rv3819, (MTCY409.11c), len: 111 aa. Hypothetical unknown protein. Contains PS00012 Phosphopantetheine attachment site.; hypothetical protein	4283996..4284331	Mycobacterium tuberculosis H37Rv	886146
YP_178020.1	CDS	papA2	NC_000962.2	4284419	4285825	R	Rv3820c, (MTCY409.10), len: 468 aa. Possible papA2, conserved polyketide synthase (PKS) associated protein, highly similar to Q49618|PAPA3|ML1230|B1170_C1_180 PKS-ASSOCIATED PROTEIN A3 from Mycobacterium leprae (471 aa), FASTA scores: opt: 1660, E(): 2.7e-102, (53.95% identity in 456 aa overlap). Also similar to Q9F2R3|SCD65.19c HYPOTHETICAL 52.8 KDA PROTEIN from Streptomyces coelicolor (473 aa), FASTA scores: opt: 575, E(): 1.8e-30, (27.8% identity in 464 aa overlap); and weakly similar to part of other proteins. Also high similarity with other PKS-ASSOCIATED PROTEINS from Mycobacterium tuberculosis; O50438|PAPA3|Rv1182|MTV005.18 (472 aa), FASTA scores: opt: 1694, E(): 1.5e-104, (53.8% identity in 461 aa overlap); and O07799|PAPA1|Rv3824c|MTCY409.06 (511 aa), FASTA scores: opt: 1664, E(): 1.6e-102, (53.9% identity in 462 aa overlap); and similar to C-terminal end of O53902|PAPA4|Rv1528c|MTV045.02 (165 aa), FASTA scores: opt: 186, E(): 4.1e-05, (37.9% identity in 66 aa overlap).; polyketide synthase associated protein PapA2	complement(4284419..4285825)	Mycobacterium tuberculosis H37Rv	886140
NP_218338.1	CDS	Rv3821	NC_000962.2	4285973	4286686	D	Rv3821, (MTCY409.09c), len: 237 aa. Probable conserved integral membrane protein, equivalent to Q49630|ML1233|B1170_F2_64 HYPOTHETICAL 24.4 KDA PROTEIN /INTEGRAL MEMBRANE PROTEIN (POTENTIAL) from Mycobacterium leprae (230 aa), FASTA scores: opt: 619, E(): 2.4e-32, (46.65% identity in 240 aa overlap). Shows some similarity to P29466|I1BC_HUMAN|CASP1|IL1BC|IL1BCE (404 aa), FASTA scores: opt: 126, E(): 0.88, (29.05% identity in 155 aa overlap). Also highly similar to P71796|Rv1517|MTCY277.39 HYPOTHETICAL 26.9 KDA PROTEIN from Mycobacterium tuberculosis (254 aa), FASTA scores: opt: 284, E(): 5.4e-11, (36.35% identity in 256 aa overlap). Start site chosen on basis of similarity to LEPB1170_F2_64 and MTCY277.39, but may extend further upstream.; integral membrane protein	4285973..4286686	Mycobacterium tuberculosis H37Rv	886141
NP_218339.1	CDS	Rv3822	NC_000962.2	4286721	4287935	D	Rv3822, (MTCY409.08c), len: 404 aa. Conserved hypothetical protein, similar in part to hypothetical proteins from Mycobacterium leprae: Q9CC62|ML1232 (358 aa) FASTA scores: opt: 601, E(): 1.1e-25, (36.7% identity in 335 aa overlap); and Q49633|B1170_F3_112 (391 aa) FASTA scores: opt: 601, E(): 1.2e-25, (36.25% identity in 347 aa overlap). Also similar to P71862|Rv3539|MTCY03C7.17c PPE FAMILY PROTEIN from Mycobacterium tuberculosis (479 aa), FASTA scores: opt: 547, E(): 1.3e-22, (38.1% identity in 281 aa overlap); O50440|Rv1184c|MTV005.20c (359 aa); O06828|Rv1430|MTCY493.24c (528 aa); O53642|Rv0159c|MTV032.02c (468 aa); etc.; hypothetical protein	4286721..4287935	Mycobacterium tuberculosis H37Rv	886155
NP_218340.1	CDS	mmpL8	NC_000962.2	4288260	4291529	R	Rv3823c, (MTCY409.07), len: 1089 aa. Probable mmpL8, conserved integral membrane transport protein (see Tekaia et al., 1999), member of RND superfamily, equivalent to Q49619|MMLA_MYCLE|MMPL10|TP1|ML1231|B1170_C1_181 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (1008 aa), FASTA scores: opt: 2718, E(): 7.3e-149, (56.25% identity in 1028 aa overlap). Also similar to others e.g. Q9XCF6|TMTPC from Mycobacterium avium (974 aa), FASTA scores: opt: 660, E(): 2.7e-30, (28.2% identity in 1050 aa overlap); Q9XCF5|TMTPB from Mycobacterium avium (963 aa), FASTA scores: opt: 653, E(): 6.7e-30, (27.0% identity in 1014 aa overlap); Q9KH53|TMTPC from Mycobacterium smegmatis (994 aa), FASTA scores: opt: 648, E(): 1.3e-29, (28.45% identity in 1013 aa overlap); etc. Also highly similar to other mmpL proteins from Mycobacterium tuberculosis; O50439|MMLA_MYCTU|MMPL10|RV1183|MT1220|MTV005.19 (1002 aa), FASTA scores: opt: 2777, E(): 2.9e-152, (58.25% identity in 996 aa overlap); Q50585|MMLC_MYCTU|MMPL12|Rv1522c|MT1573|MTCY19G5.06 (1146 aa), FASTA scores: opt: 2433, E(): 2.1e-132, (49.9% identity in 1050 aa overlap); and similar to others e.g. P95235|MML9_MYCTU|MMPL9|Rv2339|MT2402|MTCY98.08 (962 aa), FASTA scores: opt: 651, E(): 8.8e-30, (28.6% identity in 1038 aa overlap); etc. BELONGS TO THE MMPL FAMILY.; integral membrane transport protein	complement(4288260..4291529)	Mycobacterium tuberculosis H37Rv	886145
NP_218341.1	CDS	papA1	NC_000962.2	4291639	4293174	R	Rv3824c, (MTCY409.06), len: 511 aa. Possible papA1, conserved polyketide synthase (PKS) associated protein, highly similar to Q49618|PAPA3|ML1230|B1170_C1_180 PKS-ASSOCIATED PROTEIN A3 from Mycobacterium leprae (471 aa), FASTA scores: opt: 1879, E(): 7.1e-111, (55.5% identity in 465 aa overlap). Also similar to Q9F2R3|SCD65.19c HYPOTHETICAL 52.8 KDA PROTEIN from Streptomyces coelicolor (473 aa), FASTA scores: opt: 476, E(): 1.7e-22, (26.7% identity in 464 aa overlap); and similar in part to Q09164|SIMA|CYSYN CYCLOSPORIN SYNTHETASE from Tolypocladium inflatum (15281 aa) FASTA scores: opt: 238, E(): 2.8e-06, (22.35% identity in 371 aa overlap). Also highly similar to other PKS-ASSOCIATED PROTEINS from Mycobacterium tuberculosis; O50438|PAPA3|Rv1182|MTV005.18 (472 aa), FASTA scores: opt: 1862, E(): 8.4e-110, (55.95% identity in 470 aa overlap); and upstream ORF O07803|PAPA2|Rv3820c|MTCY409.10 (468 aa) FASTA scores: opt: 1664, E(): 2.5e-97, (53.9% identity in 462 aa overlap). Contains PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.; polyketide synthase associated protein	complement(4291639..4293174)	Mycobacterium tuberculosis H37Rv	886156
NP_218342.1	CDS	pks2	NC_000962.2	4293225	4299605	R	Rv3825c, (MTCY409.05), len: 2126 aa. Probable pks2, polyketide synthase (EC undetermined) (see citation below), equivalent to Q9CD78|MAS|ML0139 PUTATIVE MYCOCEROSIC SYNTHASE from Mycobacterium leprae (2116 aa), FASTA scores: opt: 6828, E(): 0, (63.3% identity in 2128 aa overlap); and Q49624|PKS3|MASA|ML1229|B1170_C2_209 PROBABLE MYCOCEROSIC ACID SYNTHASE from Mycobacterium leprae (2118 aa) FASTA scores: opt: 5220, E(): 0, (62.4% identity in 2130 aa overlap); or similar in part to others from Mycobacterium leprae e.g. Q9CB70|ML2354 POLYKETIDE SYNTHASE (1822 aa) FASTA scores: opt: 2787, E(): 2.1e-145, (34.7% identity in 2135 aa overlap). Also highly similar to Q02251|MCAS_MYCBO|MAS MYCOCEROSIC ACID SYNTHASE from Mycobacterium bovis (2110 aa), FASTA scores: opt: 3495, E(): 2.6e-184, (61.65% identity in 2130 aa overlap). Also highly similar to other polyketide synthases from Mycobacterium tuberculosis e.g. O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.01 (2108 aa) FASTA scores: opt: 9576, E(): 0, (69.8% identity in 2124 aa overlap); P96291|MAS|Rv2940c|MTCY24G1.09|MTCY19H9.08c (2111 aa), FASTA scores: opt: 3518, E(): 1.4e-185, (64.05% identity in 2126 aa overlap); O50437|PKS4|Rv1181|MTV005.17 (1582 aa), FASTA scores: opt: 3461, E(): 1.6e-182, (64.55% identity in 1609 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site and PS00012 Phosphopantetheine attachment site.; polyketide synthase PKS2	complement(4293225..4299605)	Mycobacterium tuberculosis H37Rv	886148
NP_218343.1	CDS	fadD23	NC_000962.2	4299812	4301566	D	activates fatty acids by binding to coenzyme A; acyl-CoA synthetase	4299812..4301566	Mycobacterium tuberculosis H37Rv	886154
NP_218344.1	CDS	Rv3827c	NC_000962.2	4301563	4302789	R	Rv3827c, (MTCY409.03), len: 408 aa. Possible transposase within IS1537 element, similar to several transposases e.g. O83029|TNPC|DR2324|DR0666|DR0978|DR1381|DR1651|DR1933 TRANSPOSASE from Deinococcus radiodurans(408 aa) FASTA scores: opt: 302, E(): 3.9e-12, (30.75% identity in 358 aa overlap); Q9RXX7|DR0178 PUTATIVE TRANSPOSASE from Deinococcus radiodurans (409 aa), FASTA scores: opt: 297, E(): 8.2e-12, (31.1% identity in 360 aa overlap); P73816|SLR2062 TRANSPOSASE from Synechocystis sp. strain PCC 6803 (400 aa), FASTA scores: opt: 296, E(): 9.3e-12, (30.05% identity in 353 aa overlap); etc. Highly similar to proteins from Mycobacterium tuberculosis e.g. O33333|Rv2791c|MTV002.56c TRANSPOSASE (459 aa) FASTA scores: opt: 2211, E(): 9.4e-136, (87.75% identity in 367 aa overlap); P95117|Rv2978c|MTCY349.09 HYPOTHETICAL 51.4 KDA PROTEIN (459 aa), FASTA scores: opt: 2165, E(): 9e-133, (85.85% identity in 367 aa overlap); Q10809|YS85_MYCTU|Rv2885c|MT2953|MTCY274.16c HYPOTHETICAL 51.3 KDA PROTEIN (460 aa), FASTA scores: opt: 2127, E(): 2.6e-130, (83.95% identity in 368 aa overlap); O0777|Rv0606|MTCY19H5.16c PROBABLE TRANSPOSASE (FRAGMENT) (247 aa), FASTA scores: opt: 1405, E(): 9.3e-84, (85.3% identity in 238 aa overlap); etc.; transposase	complement(4301563..4302789)	Mycobacterium tuberculosis H37Rv	886151
NP_218345.1	CDS	Rv3828c	NC_000962.2	4302786	4303397	R	Rv3828c, (MTCY409.02), len 203 aa. Possible resolvase within IS1537 element, similar to others e.g. Q97X40|SSO1915 FIRST ORF IN TRANSPOSON ISC1913 from Sulfolobus solfataricus (213 aa), FASTA scores: opt: 275, E(): 1.6e-11, (30.6% identity in 196 aa overlap); Q9V1M0|PAB2076 RESOLVASE RELATED PROTEIN from Pyrococcus abyssi (212 aa), FASTA scores: opt: 254, E(): 4.2e-10, (29.95% identity in 197 aa overlap); Q9RMU7|ORFA PUTATIVE TRANSPOSASE (BELONGS TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS) from elicobacter pylori (Campylobacter pylori) (217 aa), FASTA scores: opt: 243, E(): 2.3e-09, (31.8% identity in 154 aa overlap); etc. Also highly similar to proteins from Mycobacterium tuberculosis e.g. O33334|Rv2792c|MTV002.57c RESOLVASE (193 aa), FASTA scores: opt: 970, E(): 1.5e-58, (79.25% identity in 193 aa overlap); O07773|Rv0605|MTCY19H5.17c PUTATIVE RESOLVASE (202 aa), FASTA scores: opt: 964, E(): 4e-58, (76.25% identity in 202 aa overlap); P95116|Rv2979c|MTCY349.08 HYPOTHETICAL 21.4 KDA PROTEIN (194 aa), FASTA scores: opt: 895, E(): 1.8e-53, (74.75% identity in 194 aa overlap); Q10831|YS86_MYCTU|Rv2886c|MT2954|MTCY274.17c HYPOTHETICAL 31.9 KDA PROTEIN (295 aa), FASTA scores: opt: 826, E(): 1.1e-48, (66.2% identity in 204 aa overlap) (similarity only at C-terminus); etc. Contains PS00397 Site-specific recombinases active site. Possible helix-turn-helix motif from aa 11-32, Score 1305 (+3.63 SD).; resolvase	complement(4302786..4303397)	Mycobacterium tuberculosis H37Rv	886160
NP_218346.1	CDS	Rv3829c	NC_000962.2	4303398	4305008	R	Rv3829c, (MTCY409.01, MTCY01A6.40), len 536 aa. Probable oxidoreductase dehydrogenase (EC 1.-.-.-), similar to others e.g. Q9A3T1|CC3121 PHYTOENE DEHYDROGENASE-RELATED PROTEIN from Caulobacter crescentus (543 aa), FASTA scores: opt: 607, E(): 9.2e-28, (28.25% identity in 552 aa overlap); Q98FP6|MLR3676 PHYTOENE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (521 aa), FASTA scores: opt: 605, E(): 1.2e-27, (28.2% identity in 546 aa overlap); Q97W24|SSO2422 PHYTOENE DEHYDROGENASE RELATED PROTEIN from Sulfolobus solfataricus (518 aa), FASTA scores: opt: 388, E(): 4.4e-15, (27.35% identity in 530 aa overlap); Q98BS8|MLL5443 PROBABLE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (524 aa), FASTA scores: opt: 374, E(): 2.9e-14, (24.35% identity in aa overlap); etc. Also similar to MTCY493.22c|Rv1432|MTCY493.22c HYPOTHETICAL 50.5 KDA PROTEIN (probable dehydrogenase) from Mycobacterium tuberculosis (25.1% identity in 295 aa overlap).; dehydrogenase	complement(4303398..4305008)	Mycobacterium tuberculosis H37Rv	886157
NP_218347.1	CDS	Rv3830c	NC_000962.2	4305056	4305685	R	Rv3830c, (MTCY01A6.39), len: 209 aa. Probable transcriptional regulator tetR family, similar to others e.g. P39885|TCMR_STRGA TETRACENOMYCIN C TRANSCRIPTIONAL REPRESSOR from Streptomyces glaucescens (226 aa) FASTA scores: opt: 255, E(): 6.1e-10, (33.65% identity in 202 aa overlap); Q9RDR0|SC4A7.02 PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (227 aa) FASTA scores: opt: 230, E(): 2.8e-08, (30.05% identity in 213 aa overlap); Q9EWU3|3SC5B7.06 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (244 aa), FASTA scores: opt: 221, E(): 1.2e-07, (32.05% identity in 181 aa overlap); Q9AJ68|BUTR PUTATIVE TRANSCRIPTIONAL REPRESSOR from Streptomyces cinnamonensis (268 aa), FASTA scores: opt: 216, E(): 2.7e-07, (37.8% identity in 119 aa overlap); etc. Contains possible helix-turn-helix motif from aa 33-54, Score 1699 (+4.97 SD). SEEMS TO BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.; transcriptional regulatory protein TetR-family	complement(4305056..4305685)	Mycobacterium tuberculosis H37Rv	886158
NP_218348.1	CDS	Rv3831	NC_000962.2	4305757	4306239	D	Rv3831, (MTCY01A6.38c), len: 160 aa. Hypothetical unknown protein.; hypothetical protein	4305757..4306239	Mycobacterium tuberculosis H37Rv	886161
NP_218349.1	CDS	Rv3832c	NC_000962.2	4306236	4306811	R	Rv3832c, (MTCY01A6.37), len: 191 aa. Conserved hypothetical protein, similar in part to various proteins e.g. Q9XBC9|CZA382.22c PUTATIVE RRNA METHYLASE from Amycolatopsis orientalis (259 aa), FASTA scores: opt: 196, E(): 1.3e-05, (38.2% identity in 110 aa overlap); CAC48459|SMB20059 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (259 aa), FASTA scores: opt: 188, E(): 4.3e-05, (33.8% identity in 136 aa overlap); Q98FP8|MLL3672 METHYL TRANSFERASE-LIKE PROTEIN from Rhizobium loti (Mesorhizobium loti) (264 aa), FASTA scores: opt: 180, E(): 0.00014, (32.05% identity in 156 aa overlap); etc.; hypothetical protein	complement(4306236..4306811)	Mycobacterium tuberculosis H37Rv	886165
NP_218350.1	CDS	Rv3833	NC_000962.2	4306867	4307658	D	Rv3833, (MTCY01A6.36c), len: 263 aa. Probable transcriptional regulator belonging to araC family, similar to others e.g. Q9KYN4|SC9H11.05 PUTATIVE ARAC-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (289 aa), FASTA scores: opt: 754, E(): 1.2e-42, (50.45% identity in 232 aa overlap); Q9HXH2|PA3830 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (270 aa), FASTA scores: opt: 501, E(): 6.2e-26, (34.85% identity in 238 aa overlap); Q9HX87|PA3927 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (262 aa), FASTA scores: opt: 496, E(): 1.3e-25, (36.45% identity in 266 aa overlap); P76241|YEAM_ECOLI|B1790 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli strain K12 (273 aa) FASTA scores: opt: 388, E(): 1.9e-18, (30.5% identity in 223 aa overlap); etc. Contains probable helix-turn-helix motif from aa 164-185, Score 2014 (+6.05 SD). SEEMS TO BELONG TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS.; AraC family transcriptional regulator	4306867..4307658	Mycobacterium tuberculosis H37Rv	886162
NP_218351.1	CDS	serS	NC_000962.2	4307655	4308914	R	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase	complement(4307655..4308914)	Mycobacterium tuberculosis H37Rv	886163
NP_218352.1	CDS	Rv3835	NC_000962.2	4309047	4310396	D	Rv3835, (MTCY01A6.34c), len: 449 aa. Probable conserved membrane protein, equivalent to Q9CDC2|ML0081 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (450 aa), FASTA scores: opt: 2079, E(): 1.8e-74, (69.35% identity in 457 aa overlap).; hypothetical protein	4309047..4310396	Mycobacterium tuberculosis H37Rv	886168
NP_218353.1	CDS	Rv3836	NC_000962.2	4310401	4310814	D	Rv3836, (MTCY01A6.33c), len: 137aa. Conserved hypothetical protein, highly similar to Q9RKJ2|SCD25.30 HYPOTHETICAL 13.1 KDA PROTEIN from Streptomyces coelicolor (116 aa), FASTA scores: opt: 395, E(): 3.3e-19, (54.4% identity in 114 aa overlap); and similar to CAC47753|SMC0379 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (144 aa) FASTA scores: opt: 194, E(): 6e-06, (33.05% identity in 109 aa overlap); and Q98E37|MLL4425 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA scores: opt: 184, E(): 3.7e-05, (29.75% identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.; hypothetical protein	4310401..4310814	Mycobacterium tuberculosis H37Rv	886164
NP_218354.1	CDS	Rv3837c	NC_000962.2	4311009	4311707	R	Rv3837c, (MTCY01A6.32), len: 232 aa. Probable phosphoglycerate mutase (EC 5.4.2.-), equivalent to Q9CDC3|ML0079 PUTATIVE PHOSPHOGLYCERATE MUTASE from Mycobacterium leprae (231 aa), FASTA scores: opt: 1116, E(): 7.3e-66, (71.55% identity in 232 aa overlap). Also similar to others e.g. Q9ZAX0|PGM 2,3-PDG DEPENDENT PHOSPHOGLYCERATE MUTASE from Amycolatopsis methanolica (205 aa), FASTA scores: opt: 474, E(): 6.4e-24, (41.85% identity in 203 aa overlap); Q9F3Q7|SC10F4.03 PUTATIVE ISOMERASE from Streptomyces coelicolor (224 aa) FASTA scores: opt: 349, E(): 1e-15, (33.2% identity in 223 aa overlap); Q9RDL0|SCC123.14c PUTATIVE PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223 aa), FASTA scores: opt: 256, E(): 1.2e-09, (34.0% identity in 203 aa overlap); Q9RVD2|DR1097 PUTATIVE PHOSPHOGLYCERATE MUTASE from Deinococcus radiodurans (232 aa), FASTA scores: opt: 201, E(): 5.1e-06, (31.45% identity in 175 aa overlap); etc. Also similar to P71724|Rv2419c|MTCY428.28|MTCY253.01 HYPOTHETICAL 24.2 KDA PROTEIN from Mycobacterium tuberculosis (223 aa), FASTA scores: opt: 210, E(): 1.3e-06, (32.0% identity in 172 aa overlap). Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature.; phosphoglycerate mutase	complement(4311009..4311707)	Mycobacterium tuberculosis H37Rv	886169
NP_218355.1	CDS	pheA	NC_000962.2	4311704	4312669	R	catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase	complement(4311704..4312669)	Mycobacterium tuberculosis H37Rv	886170
NP_218356.1	CDS	Rv3839	NC_000962.2	4312765	4313541	D	Rv3839, (MTCY01A6.30c), len: 258 aa. Conserved hypothetical protein, similar in part to Q9RD78|SCF43.10cfrom HYPOTHETICAL 25.8 KDA PROTEIN Streptomyces coelicolor (241 aa), FASTA scores: opt: 270, E(): 3.2e-10, (33.45% identity in 272 aa overlap); and O00320|F25451_2 HYPOTHETICAL PROTEIN from Homo sapiens (Human) (339 aa), FASTA scores: opt: 126, E(): 0.77, (28.75% identity in 240 aa overlap).; hypothetical protein	4312765..4313541	Mycobacterium tuberculosis H37Rv	886171
NP_218357.1	CDS	Rv3840	NC_000962.2	4313567	4313980	D	Rv3840, (MTCY01A6.29c), len: 137 aa. Possible transcriptional regulator, highly similar in part to PSR PROTEINS (PENICILLIN BINDING PROTEIN REPRESSORS) e.g. Q47828|PSR PSR PROTEIN from Enterococcus hirae (293 aa) FASTA scores: opt: 221, E(): 2.2e-07, (41.65% identity in 108 aa overlap); O86213|PSRFM PSRFM PROTEIN (FRAGMENT) from Enterococcus hirae (171 aa), FASTA scores: opt: 202, E(): 2.4e-06, (40.75% identity in 108 aa overlap); Q47865|PSR PENICILLIN BINDING PROTEIN REPRESSOR from Enterococcus hirae (148 aa), FASTA scores: opt: 201, E(): 2.5e-06, (51.65% identity in 60 aa overlap); etc. Also highly similar in part to other transcriptional regulators e.g. BAB57524|MSRR PEPTIDE METHIONINE SULFOXIDE REDUCTASE REGULATOR from Staphylococcus aureus subsp. aureus Mu50 (327 aa), FASTA scores: opt: 195, E(): 1.2e-05, (36.7% identity in 109 aa overlap); Q99Q02|MSRR|SA1195 PEPTIDE METHIONINE SULFOXIDE REDUCTASE REGULATOR from Staphylococcus aureus subsp. aureus N315, and Staphylococcus aureus (327 aa), FASTA scores: opt: 192, E(): 1.9e-05, (36.7% identity in 109 aa overlap); Q9K6Q8|LYTR|BH3670 ATTENUATOR FOR LYTABC AND LYTR EXPRESSION from Bacillus halodurans (304 aa), FASTA scores: opt: 171, E(): 0.00041, (34.5% identity in 113 aa overlap); etc.; transcriptional regulatory protein	4313567..4313980	Mycobacterium tuberculosis H37Rv	886167
NP_218358.1	CDS	bfrB	NC_000962.2	4314178	4314723	D	Rv3841, (MTCY01A6.28c), len: 181 aa. Possible bfrB, bacterioferritin, similar to other ferritin or hypothetical proteins e.g. O26261|MTH158|RSGA FERRITIN LIKE PROTEIN from Methanothermobacter thermautotrophicus (171 aa), FASTA scores: opt: 277, E(): 6.6e-11, (30.1% identity in 166 aa overlap); Q99SZ3|SA1709 HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus N315 (166 aa), FASTA scores: opt: 275, E(): 8.7e-11, (33.35% identity in 156 aa overlap); Q9X0L2|TM1128 FERRITIN from Thermotoga maritima (164 aa), FASTA scores: opt: 247, E(): 5.3e-09, (25.65% identity in 156 aa overlap); Q9KDT7|BH1124 FERRITIN from Bacillus halodurans (169 aa), FASTA scores: opt: 246, E(): 6.3e-09, (28.95% identity in 152 aa overlap); O29424|AF0834 PUTATIVE FERRITIN from Archaeoglobus fulgidu (169 aa), FASTA scores: opt: 246, E(): 6.3e-09, (28.95% identity in 152 aa overlap); etc. Also shows similarity with Rv1876|MTCY180.42|BFRA PROBABLE BACTERIOFERRITIN from Mycobacterium tuberculosis (159 aa). SEEMS BELONG TO THE BACTERIOFERRITIN FAMILY.; bacterioferritin BfrB	4314178..4314723	Mycobacterium tuberculosis H37Rv	886176
NP_218359.1	CDS	glpQ1	NC_000962.2	4314738	4315562	R	Rv3842c, (MTCY01A6.27), len: 274 aa. Probable glpQ1, glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46), equivalent to Q9CDC5|GLPQ|ML0074 PUTATIVE GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE from Mycobacterium leprae (271 aa), FASTA scores: opt: 1635, E(): 1.9e-100, (88.85% identity in 269 aa overlap). Also highly similar to others e.g. CAC44700|SCBAC25E3.13c PUTATIVE PHOSPHODIESTERASE from Streptomyces coelicolor (275 aa), FASTA scores: opt: 413, E(): 5.7e-20, (48.05% identity in 258 aa overlap); P37965|GLPQ_BACSU GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE from Bacillus subtilis (293 aa), FASTA scores: opt: 405, E(): 2e-19, (31.3% identity in 249 aa overlap); Q99VC9|GLPQ|SA0820 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE from Staphylococcus aureus subsp. aureus N315 (309 aa) FASTA scores: opt: 341, E(): 3.5e-15, (29.3% identity in 273 aa overlap); etc.; glycerophosphoryl diester phosphodiesterase	complement(4314738..4315562)	Mycobacterium tuberculosis H37Rv	886177
NP_218360.1	CDS	Rv3843c	NC_000962.2	4315568	4316596	R	Rv3843c, (MTCY01A6.26), len: 342 aa. Probable conserved transmembrane protein, equivalent to Q9CDC6|ML0073 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (344 aa), FASTA scores: opt: 1420, E(): 2.6e-68, (63.05% identity in 349 aa overlap).; transmembrane protein	complement(4315568..4316596)	Mycobacterium tuberculosis H37Rv	886178
NP_218361.1	CDS	Rv3844	NC_000962.2	4318775	4319266	D	Rv3844, (MTCY01A6.25), len: 163 aa. Possible transposase, identical to P96234|Rv3348|MTV004.04 PUTATIVE TRANSPOSASE from Mycobacterium tuberculosis. Also some similarity with others e.g. N-terminal part of P19834|YI11_STRCL INSERTION ELEMENT IS116 HYPOTHETICAL 44.8 KDA PROTEIN from Streptomyces clavuligerus (399 aa) FASTA scores: opt: 146, E(): 0.017, (29.1% identity in 158 aa overlap).; transposase	4318775..4319266	Mycobacterium tuberculosis H37Rv	886180
NP_218362.1	CDS	Rv3845	NC_000962.2	4319281	4319640	D	Rv3845, (MTCY01A6.24c), len: 119 aa. Hypothetical unknown protein. Contains PS01137 Hypothetical YBL055c/yjjV family signature 1.; hypothetical protein	4319281..4319640	Mycobacterium tuberculosis H37Rv	886179
NP_218363.1	CDS	sodA	NC_000962.2	4320704	4321327	D	Rv3846, (MTCY01A6.22c), len: 207 aa. sodA (alternate gene names: sodB, sod), superoxyde dismutase (EC 1.15.1.1) (see citations below), equivalent to many e.g. P47201|SODM_MYCAV|SODA|SOD from Mycobacterium avium (206 aa), FASTA scores: opt: 1210, E(): 1.8e-73, (82.5% identity in 206 aa overlap); Q9F9R1|SOD from Mycobacterium paratuberculosis (207 aa), FASTA scores: opt: 1207, E(): 2.9e-73, (81.65% identity in 207 aa overlap); O86165|SODM_MYCLP|SODA|SOD from Mycobacterium lepraemurium (206 aa), FASTA scores: opt: 1204, E(): 4.5e-73, (82.05% identity in 206 aa overlap); P13367|SODM_MYCLE|SODA|ML0072 from Mycobacterium leprae (206 aa), FASTA scores: opt: 1169, E(): 9.6e-71, (80.5% identity in 205 aa overlap); etc. Contains PS00088 Manganese and iron superoxide dismutases signature. BELONGS TO THE IRON/MANGANESE SUPEROXIDE DISMUTASE FAMILY. ALTHOUGH FOUND EXTRACELLULARLY, NO SIGNAL SEQUENCE IS PRESENT. AN ALTERNATIVE SECRETORY PATHWAY MAY BE USED.; sodB; sod; superoxide dismutase [Fe] SODA	4320704..4321327	Mycobacterium tuberculosis H37Rv	886174
NP_218364.1	CDS	Rv3847	NC_000962.2	4321538	4322071	D	Rv3847, (MTCY01A6.21c), len: 177 aa. Conserved hypothetical protein, equivalent to Q9CDC7|ML0071 HYPOTHETICAL PROTEIN from Mycobacterium leprae (177 aa) FASTA scores: opt: 1149, E(): 1.6e-64, (96.6% identity in 177 aa overlap); and Q9F9R0 HYPOTHETICAL 18.5 KDA PROTEIN from Mycobacterium paratuberculosis (177 aa), FASTA scores: opt: 1139, E(): 6.8e-64, (96.6% identity in 177 aa overlap).; hypothetical protein	4321538..4322071	Mycobacterium tuberculosis H37Rv	886182
NP_218365.1	CDS	Rv3848	NC_000962.2	4322326	4323234	D	Rv3848, (MTCY01A6.20c), len: 302 aa. Probable conserved transmembrane protein, similar to hypothetical (transmembrane) proteins e.g. Q9HVG2|PA4629 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (192 aa), FASTA scores: opt: 304, E(): 5.3e-11, (35.05% identity in 174 aa overlap); Q9A5S7|CC2370 HYPOTHETICAL PROTEIN from Caulobacter crescentus (207 aa), FASTA scores: opt: 285, E(): 7.4e-10, (29.9% identity in 184 aa overlap); Q9KY43|SCC8A.05c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (193 aa), FASTA scores: opt: 245, E(): 1.6e-07, (32.8% identity in 195 aa overlap); etc.; transmembrane protein	4322326..4323234	Mycobacterium tuberculosis H37Rv	886159
NP_218366.1	CDS	Rv3849	NC_000962.2	4323499	4323897	D	Rv3849, (MTCY01A6.19c), len: 132 aa. Conserved hypothetical protein, equivalent to Q9CDC9|ML0069 HYPOTHETICAL PROTEIN from Mycobacterium leprae (132 aa) FASTA scores: opt: 724, E(): 8.7e-41, (83.95% identity in 131 aa overlap).; hypothetical protein	4323499..4323897	Mycobacterium tuberculosis H37Rv	886184
NP_218367.1	CDS	Rv3850	NC_000962.2	4324015	4324671	D	Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved hypothetical protein, equivalent to Q9CDD0|ML0068 HYPOTHETICAL PROTEIN from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071, E(): 7.2e-55, (78.35% identity in 217 aa overlap).; hypothetical protein	4324015..4324671	Mycobacterium tuberculosis H37Rv	886173
NP_218368.1	CDS	Rv3851	NC_000962.2	4324683	4324967	D	Rv3851, (MTCY01A6.17c), len: 94 aa. Possible membrane protein.; hypothetical protein	4324683..4324967	Mycobacterium tuberculosis H37Rv	886186
NP_218369.1	CDS	hns	NC_000962.2	4325074	4325478	D	Rv3852, (MTCY01A6.16c), len: 134 aa. Possible hns, histone-like protein, equivalent to Q9CDD1|HNS|ML0067 HISTONE-LIKE PROTEIN from Mycobacterium leprae (121 aa), FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 HISTONE H1 from Triticum aestivum (Wheat) (288 aa), FASTA scores: opt: 183, E(): 0.091, (34.85% identity in 109 aa overlap); etc.; histone-like protein HNS	4325074..4325478	Mycobacterium tuberculosis H37Rv	886187
NP_218370.1	CDS	menG	NC_000962.2	4325495	4325968	D	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA	4325495..4325968	Mycobacterium tuberculosis H37Rv	886181
NP_218371.1	CDS	ethA	NC_000962.2	4326004	4327473	R	Rv3854c, (MTCY01A6.14), len: 489 aa. ethA (alternate gene names: aka, etaA), monooxygenase required for activation of the pro-drug ethionamide (EC 1.-.-.-) (see citations below), highly similar to other monooxygenases e.g. Q9A588|CC2569 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (498 aa), FASTA scores: opt: 1959, E(): 2.9e-114, (57.6% identity in 481 aa overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from Deinococcus radiodurans (833 aa), FASTA scores: opt: 1771, E(): 2.2e-102, (53.75% identity in 480 aa overlap); Q9A8K5|CC1348 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (499 aa), FASTA scores: opt: 1385, E(): 1.4e-78, (43.2% identity in 486 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. O53300|Rv3083|MTV013.04 MONOXYGENASE (495 aa) FASTA scores: opt: 1692, E(): 1.1e-97, (49.7% identity in 489 aa overlap); O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa), FASTA scores: opt: 1571, E(): 3.7e-90, (49.05% identity in 471 aa overlap); O69708|Rv3741c|MTV025.089c POSSIBLE OXIDOREDUCTASE (probably second part of a two component monooxygenase) (224 aa), FASTA scores: opt: 542, E(): 1.7e-26, (50.0% identity in 162 aa overlap); etc.; aka; etaA; monooxygenase ETHA	complement(4326004..4327473)	Mycobacterium tuberculosis H37Rv	886175
NP_218372.1	CDS	ethR	NC_000962.2	4327549	4328199	D	Rv3855, (MTCY01A6.13c), len: 216 aa. ethR (alternate gene names: aka, etaR), regulatory protein tetR family, involved in ethionamide sensitivity/resistance, negatively controls neighbouring ethA (Rv3854c, MTCY01A6.14; alternate gene names: aka etaA) (see citations below). Equivalent to Q9CDD3|ML0064 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (214 aa), FASTA scores: opt: 1017, E(): 7e-62, (77.0% identity in 213 aa overlap). Also similar to other transcriptional regulator e.g. Q9S1R1|SCJ9A.09 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (204 aa), FASTA scores: opt: 305, E(): 1.2e-13, (34.5% identity in 200 aa overlap); Q9KYT9|SCE22.24 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR (FRAGMENT) from Streptomyces coelicolor (244 aa), FASTA scores: opt: 179, E(): 4.9e-05, (35.5% identity in 93 aa overlap); Q9RUK2|DR1384 TRANSCRIPTIONAL REGULATOR (TETR FAMILY) from Deinococcus radiodurans (196 aa), FASTA scores: opt: 167, E(): 0.00026, (41.75% identity in 79 aa overlap); etc. Also similar to P95100|Rv3058c|MTCY22D7.23 HYPOTHETICAL 23.8 KDA PROTEIN from Mycobacterium tuberculosis (216 aa) FASTA scores: opt: 261, E(): 1.2e-10, (31.65% identity in 221 aa overlap); and O08377|Rv1534|MTCY07A7A.03 HYPOTHETICAL 24.5 KDA PROTEIN from Mycobacterium tuberculosis (225 aa), FASTA scores: opt: 164, E(): 0.00047, (25.5% identity in 248 aa overlap). Contains helix-turn-helix motif at aa 45-66, Score 1320 (+3.68 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS.; aka; etaR; transcriptional regulatory repressor protein (TETR-family) ETHR	4327549..4328199	Mycobacterium tuberculosis H37Rv	886189
NP_218373.1	CDS	Rv3856c	NC_000962.2	4328401	4329408	R	Rv3856c, (MTCY01A6.12), len: 335 aa. Conserved hypothetical protein, highly similar to various proteins from diverse organisms e.g. Q9EWR3|3SCF60.21 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (372 aa) FASTA scores: opt: 1286, E(): 2.4e-73, (64.0% identity in 336 aa overlap); P72464|ORF1 from Streptomyces lividans (343 aa), FASTA scores: opt: 1275, E(): 1.1e-72, (60.1% identity in 336 aa overlap); Q9K899|BH3107 DNA-DEPENDENT DNA POLYMERASE BETA CHAIN from Bacillus halodurans (571 aa), FASTA scores: opt: 592, E(): 1.2e-29, (39.15% identity in 240 aa overlap); etc. May be a DNA polymerase beta (gene name: yshC) (see citation below).; hypothetical protein	complement(4328401..4329408)	Mycobacterium tuberculosis H37Rv	886193
NP_218374.1	CDS	Rv3857c	NC_000962.2	4329417	4329614	R	Rv3857c, (MTCY01A6.11), len: 65 aa. Possible membrane protein.; hypothetical protein	complement(4329417..4329614)	Mycobacterium tuberculosis H37Rv	886192
NP_218375.1	CDS	gltD	NC_000962.2	4330039	4331505	R	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta	complement(4330039..4331505)	Mycobacterium tuberculosis H37Rv	886196
NP_218376.1	CDS	gltB	NC_000962.2	4331498	4336081	R	Rv3859c, (MTCY01A6.09), len: 1527 aa. Probable gltB, ferredoxin-dependent glutamate synthase large subunit (EC 1.4.1.13), equivalent to Q9CDD5|GLTB|ML0061 PUTATIVE FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE from Mycobacterium leprae (1527 aa), FASTA scores: opt: 9277, E(): 0, (90.25% identity in 1527 aa overlap). Also highly similar to many e.g. Q9S2Y9|SC3A3.04c from Streptomyces coelicolor (1514 aa), FASTA scores: opt: 5939, E(): 0, (64.3% identity in 1544 aa overlap); Q9Z465|GLTB from Corynebacterium glutamicum (Brevibacterium flavum) (1510 aa), FASTA scores: opt: 5790, E(): 0, (63.25% identity in 1534 aa overlap); P39812|GLTB_BACSU|GLTA from Bacillus subtilis (1520 aa), FASTA scores: opt: 3445, E(): 2.8e-196, (52.25% identity in 1531 aa overlap); etc. SIMILAR TO OTHER GLUTAMATE SYNTHASES.; ferredoxin-dependent glutamate synthase [NADPH] large subunit	complement(4331498..4336081)	Mycobacterium tuberculosis H37Rv	886195
NP_218377.1	CDS	Rv3860	NC_000962.2	4336777	4337949	D	Rv3860, (MTCY01A6.08c), len: 390 aa. Conserved hypothetical protein, showing similarity with hypothetical proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 (586 aa), FASTA scores: opt: 484, E(): 5.5e-14, (29.95% identity in 407 aa overlap); O33082|MLCB628.11c (478 aa) FASTA scores: opt: 484, E(): 4.8e-14, (29.95% identity in 407 aa overlap); etc. Also some similarity with O86637|SC3C3.03c HYPOTHETICAL 112.1 KDA PROTEIN from Streptomyces coelicolor(1083 aa), FASTA scores: opt: 483, E(): 9.6e-14, (30.45% identity in 404 aa overlap). And some similarity with other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O05456|Rv3888c|MTCY15F10.24 HYPOTHETICAL 37.7 KDA PROTEIN (341 aa), FASTA scores: opt: 603, E(): 2.8e-19, (35.2% identity in 284 aa overlap); O06396|Rv0530|MTCY25D10.09 HYPOTHETICAL 43.0 KDA PROTEIN (405 aa), FASTA scores: opt: 538, E(): 2e-16, (31.0% identity in 371 aa overlap); O69740|Rv3876|MTV027.11 (666 aa), FASTA scores: opt: 475, E(): 1.5e-13, (30.2% identity in 391 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	4336777..4337949	Mycobacterium tuberculosis H37Rv	886188
NP_218378.1	CDS	Rv3861	NC_000962.2	4337946	4338272	D	Rv3861, (MTCY01A6.07c), len: 108 aa. Hypothetical unknown protein. Overlaps in part next ORF Rv3862c|whiB6.; hypothetical protein	4337946..4338272	Mycobacterium tuberculosis H37Rv	886183
NP_218379.1	CDS	whiB6	NC_000962.2	4338171	4338521	R	Rv3862c, (MTCY01A6.06), len: 116 aa. Possible whiB6 (alternate gene name: whmF), WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Shows similarity with Q49765|WHIB7|ML0639|B1937_F2_68 PUTATIVE TRANSCRIPTIONAL REGULATOR WHIB7 from Mycobacterium leprae (89 aa) FASTA scores: opt: 112, E(): 0.49, (41.2% identity in 51 aa overlap). Some similarity to Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa) FASTA scores: opt: 129, E(): 0.038, (32.95% identity in 85 aa overlap); AAK47632|MT3290.1 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (96 aa), FASTA scores: opt: 126, E(): 0.058, (33.35% identity in 84 aa overlap); Q9FC80|SC4B10.07 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (88 aa), FASTA scores: opt: 119, E(): 0.16, (44.65% identity in 70 aa overlap); Q9K4K8|SC5F8.16c REGULATORY PROTEIN from Streptomyces coelicolor (83 aa), FASTA scores: opt: 114, E(): 0.34, (37.05% identity in 54 aa overlap); etc.; whmF; transcriptional regulatory protein WHIB-like WHIB6	complement(4338171..4338521)	Mycobacterium tuberculosis H37Rv	886190
NP_218380.1	CDS	Rv3863	NC_000962.2	4338849	4340027	D	Rv3863, (MTCY01A6.05c), len: 392 aa. Hypothetical unknown ala-rich protein.; hypothetical protein	4338849..4340027	Mycobacterium tuberculosis H37Rv	886197
NP_218381.1	CDS	Rv3864	NC_000962.2	4340270	4341478	D	Rv3864, (MTCY01A6.04c), len: 402 aa. Conserved hypothetical protein, similar to Q49722|ML0405|B1620_C2_213|MLCL383.01 HYPOTHETICAL 40.8 KDA PROTEIN from Mycobacterium leprae (394 aa) FASTA scores: opt: 397, E(): 1.2e-12, (31.0% identity in 410 aa overlap). Also similar to various proteins from several organisms e.g. Q9VYF9|CG12723 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (450 aa), FASTA scores: opt: 291, E(): 2.3e-07, (34.6% identity in 130 aa overlap); Q98UE3 PROCOLLAGEN ALPHA1(III) (FRAGMENT) from Xenopus laevis (African clawed frog) (117 aa) FASTA scores: opt: 257, E(): 3.6e-06, (41.75% identity in 103 aa overlap); P27393|CA24_ASCSU COLLAGEN ALPHA 2(IV) CHAIN PRECURSOR from Ascaris suum (Pig roundworm) (Ascaris lumbricoides) (1763 aa), FASTA scores: opt: 273, E(): 5.7e-06, (32.1% identity in 240 aa overlap); etc. Also similar to O06267|Rv3616c|MTCY07H7B.06 (392 aa) FASTA scores: opt: 389, E(): 3e-12, (31.6% identity in 399 aa overlap).; hypothetical protein	4340270..4341478	Mycobacterium tuberculosis H37Rv	886185
NP_218382.1	CDS	Rv3865	NC_000962.2	4341566	4341877	D	Rv3865, (MTCY01A6.03c), len: 103 aa. Conserved hypothetical protein, showing some similarity to O06268|Rv3615c|MTCY07H7B.07 HYPOTHETICAL 10.8 KDA PROTEIN from Mycobacterium tuberculosis (103 aa), FASTA scores: opt: 198, E(): 7.5e-07, (36.25% identity in 102 aa overlap); Q49723|ML0406|B1620_C2_214|MLCL383.02 HYPOTHETICAL 11.1 KDA PROTEIN from Mycobacterium leprae (106 aa), FASTA scores: opt: 154, E(): 0.00071, (31.05% identity in 103 aa overlap).; hypothetical protein	4341566..4341877	Mycobacterium tuberculosis H37Rv	886172
NP_218383.1	CDS	Rv3866	NC_000962.2	4341880	4342731	D	Rv3866, (MTCY01A6.01c, MTV027.01), len: 283 aa. Conserved hypothetical protein. N-terminal end highly similar to O33091|MLCB628.20c HYPOTHETICAL 13.1 KDA PROTEIN from Mycobacterium leprae (122 aa), FASTA scores: opt: 260, E(): 2.1e-09, (43.6% identity in 117 aa overlap); and C-terminal end highly similar to O33090|MLCB628.19c HYPOTHETICAL 36.7 KDA PROTEIN from Mycobacterium leprae (338 aa), FASTA scores: opt: 540, E(): 1.4e-26, (54.5% identity in 156 aa overlap). Also similar to Q9CD34|ML2530 POSSIBLE DNA-BINDING PROTEIN from Mycobacterium leprae (289 aa), FASTA scores: opt: 146, E(): 0.058, (28.25% identity in 269 aa overlap) and O53694|Rv0289|MTV035.17 HYPOTHETICAL 31.6 KDA PROTEIN from Mycobacterium tuberculosis (295 aa), FASTA scores: opt: 133, E(): 0.39, (28.15% identity in 277 aa overlap).; hypothetical protein	4341880..4342731	Mycobacterium tuberculosis H37Rv	886200
NP_218384.1	CDS	Rv3867	NC_000962.2	4342770	4343321	D	Rv3867, (MTV027.02), len: 183 aa. Conserved hypothetical protein, highly similar to the hypothetical proteins from Mycobacterium leprae: Q9CDD6|ML0056 (169 aa) FASTA scores: opt: 403, E(): 1.8e-18, (48.2% identity in 166 aa overlap); Q49730|ML0407|B1620_C3_264|MLCL383.03 (216 aa), FASTA scores: opt: 517, E(): 1.7e-25, (51.45% identity in 175 aa overlap); and O33090|MLCB628.19c (338 aa), FASTA scores: opt: 403, E(): 3.4e-18, (48.2% identity in 166 aa overlap). Also highly similar to O06269|Rv3614c|MTCY07H7B.08 HYPOTHETICAL 19.8 KDA PROTEIN from Mycobacterium tuberculosis (184 aa), FASTA scores: opt: 559, E(): 3.4e-28, (54.35% identity in 173 aa overlap).; hypothetical protein	4342770..4343321	Mycobacterium tuberculosis H37Rv	886203
NP_218385.1	CDS	Rv3868	NC_000962.2	4343314	4345035	D	Rv3868, (MTV027.03), len: 573 aa. Member of the CBXX/CFQX family of hypothetical proteins; C-terminal end is highly similar to many e.g. P40118|CBXC_ALCEU|CBXXC|CFXXC CBXX PROTEIN (317 aa) FASTA scores: opt: 572, E(): 3e-24, (42.7% identity in 294 aa overlap); CAC48589 PROBABLE CBBX PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (311 aa) FASTA scores: opt: 569, E(): 4.3e-24, (40.05% identity in 292 aa overlap); P95648|CBBX_RHOSH CBBX PROTEIN from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (309 aa), FASTA scores: opt: 559, E(): 1.5e-23, (41.4% identity in 290 aa overlap); etc. Equivalent to O33089|Y2G8_MYCLE|ML0055|MLCB628.18c HYPOTHETICAL 62.3 KDA PROTEIN from Mycobacterium leprae (573 aa), FASTA scores: opt: 3330, E(): 3.9e-175, (89.2% identity in 573 aa overlap); and similar to Q9CD28|Y282_MYCLE|ML2537 HYPOTHETICAL 69.1 KDA PROTEIN from Mycobacterium leprae (640 aa), FASTA scores: opt: 943, E(): 2.4e-44, (37.5% identity in 571 aa overlap). Also similar to many proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10 HYPOTHETICAL 68.1 KDA PROTEIN (631 aa), FASTA scores: opt: 936, E(): 5.8e-44, (39.05% identity in 568 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein	4343314..4345035	Mycobacterium tuberculosis H37Rv	886199
NP_218386.1	CDS	Rv3869	NC_000962.2	4345039	4346481	D	Rv3869, (MTV027.04), len: 480 aa. Possible conserved membrane protein (has hydrophobic stretch near N-terminus), equivalent to O33088|ML0054|MLCB628.17c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (481 aa), FASTA scores: opt: 2489, E(): 8.3e-136, (75.75% identity in 478 aa overlap); and similar to others e.g. Q9Z5I3|ML1544|MLCB596.27 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (506 aa), FASTA scores: opt: 739, E(): 3.9e-35, (33.65% identity in 490 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. O05449|Rv3895c|MTCY15F10.17 (495 aa), FASTA scores: opt: 795, E(): 2.3e-38, (35.8% identity in 486 aa overlap); O53933|Rv1782|MTV049.04 (506 aa), FASTA scores: opt: 763, E(): 1.6e-36, (34.7% identity in 490 aa overlap); O06317|Rv3450c|MTCY13E12.03c (470 aa) FASTA scores: opt: 717, E(): 6.7e-34, (32.55% identity in 479 aa overlap); etc.; hypothetical protein	4345039..4346481	Mycobacterium tuberculosis H37Rv	886166
NP_218387.1	CDS	Rv3870	NC_000962.2	4346481	4348724	D	Rv3870, (MTV027.05), len: 747 aa. Possible conserved transmembrane protein, equivalent to O33087|ML0053|MLCB628.16c PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (744 aa), FASTA scores: opt: 4333, E(): 0, (85.4% identity in 746 aa overlap); and similar to N-terminal end of others e.g. Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa), FASTA scores: opt: 1003, E(): 1e-52, (33.65% identity in 725 aa overlap); O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1078, E(): 3e-57, (35.4% identity in 774 aa overlap); P71068|YUKA YUKA PROTEIN from Bacillus subtilis (1207 aa) FASTA scores: opt: 529, E(): 4.3e-24, (26.1% identity in 636 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa), FASTA scores: opt: 455, E(): 1.5e-19, (27.1% identity in 734 aa overlap); etc. Also similar to N-terminal end of hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 982, E(): 1.9e-51, (33.8% identity in 719 aa overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt: 761, E(): 4.1e-38, (38.2% identity in 746 aa overlap); O53935|Rv1784|MTV049.06 (932 aa), FASTA scores: opt: 547, E(): 2.8e-25, (36.25% identity in 276 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Note some similarity (with hypothetical proteins from Mycobacterium tuberculosis and P71068|YUKA) continues in downstream ORF MTV027.06.; transmembrane protein	4346481..4348724	Mycobacterium tuberculosis H37Rv	886204
NP_218388.1	CDS	Rv3871	NC_000962.2	4348827	4350602	D	Rv3871, (MTV027.06), len: 591 aa. Conserved hypothetical protein, equivalent to Q9CDD7|ML0052 HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa) FASTA scores: opt: 3341, E(): 9.8e-192, (80.85% identity in 596 aa overlap); and O33086|MLCB628.15c HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FASTA scores: opt: 3329, E(): 5.1e-191, (80.55% identity in 596 aa overlap). And similar to C-terminal end of others e.g. Q9Z5I2|ML1543|MLCB596.28 POSSIBLE SPOIIIE-FAMILY MEMBRANE PROTEIN from Mycobacterium leprae (1345 aa), FASTA scores: opt: 601, E(): 5.6e-28, (32.3% identity in 613 aa overlap); O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 977, E(): 2.1e-50, (35.15% identity in 583 aa overlap); Q9L0T6|SCD35.15c PUTATIVE CELL DIVISION-RELATED PROTEIN from Streptomyces coelicolor (1525 aa), FASTA scores: opt: 414, E(): 9e-17, (27.6% identity in 424 aa overlap);P71068|YUKA YUKA PROTEIN from Bacillus subtilis (1207 aa), FASTA scores: opt: 343, E(): 1.3e-12, (25.8% identity in 395 aa overlap); etc. And similar to to C-terminal end of hypothetical proteins from Mycobacterium tuberculosis e.g. O06264|Rv3447c|MTCY77.19c (1236 aa) FASTA scores: opt: 845, E(): 1.5e-42, (35.3% identity in 586 aa overlap); O53689|Rv0284|MTV035.12 (1330 aa) FASTA scores: opt: 646, E(): 1.2e-30, (33.35% identity in 606 aa overlap); O53935|Rv1784|MTV049.06 (932 aa) FASTA scores: opt: 589, E(): 2.1e-27, (33.1% identity in 619 aa overlap); etc. Contains 2 X PS00017 ATP/GTP-binding site motif A (P-loop). Note some similarity (with hypothetical proteins from Mycobacterium tuberculosis and P71068|YUKA) continues in upstream ORF MTV027.05.; hypothetical protein	4348827..4350602	Mycobacterium tuberculosis H37Rv	886202
YP_178021.1	CDS	PE35	NC_000962.2	4350745	4351044	D	Rv3872, (MTV027.07), len: 99 aa. Some similarity to Mycobacterium tuberculosis conserved PE family proteins (see Brennan & Delogu 2002), e.g. O69713|Rv3746c|MTV025.094c (111 aa), FASTA scores: opt: 306, E(): 5.5e-13, (50.5% identity in 99 aa overlap). Equivalent to AAK48354 from Mycobacterium tuberculosis strain CDC1551 (112 aa) but shorter 14 aa.; PE family-related protein	4350745..4351044	Mycobacterium tuberculosis H37Rv	886191
YP_178022.1	CDS	PPE68	NC_000962.2	4351075	4352181	D	Rv3873, (MTV027.08), len: 368 aa. Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O33085|ML0051|MLCB628.14c from Mycobacterium leprae (302 aa), FASTA scores: opt: 656, E(): 2.8e-24, (46.2% identity in 288 aa overlap); and O53691|Rv0286|MTV035.14 (513 aa), FASTA scores: opt: 566, E(): 7.8e-20, (35.25% identity in 363 aa overlap).; PPE family protein	4351075..4352181	Mycobacterium tuberculosis H37Rv	886201
NP_218391.1	CDS	esxB	NC_000962.2	4352274	4352576	D	Rv3874, (MT3988, MTV027.09), len: 100 aa. esxB, 10 KDA culture filtrate antigen (see citations below, especially first), highly similar to O33084|CF10_MYCLE|ML0050|MLCB628.13c 10 KDA CULTURE FILTRATE ANTIGEN CFP10 HOMOLOG from Mycobacterium leprae (99 aa), FASTA scores: opt: 237, E(): 2.4e-08, (39.4% identity in 99 aa overlap). Also similar to O05440|ES6D_MYCTU|Rv3905c|MT4024|MTCY15F10.06 PUTATIVE ESAT-6 LIKE PROTEIN 13 from Mycobacterium tuberculosis (103 aa) FASTA scores: opt: 126, E(): 0.18, (23.1% identity in 91 aa overlap); and shows some similarity with other proteins from Mycobacterium tuberculosis. Contains probable coiled-coil from aa 49-93. BELONGS TO THE ESAT6 FAMILY. Note that previously known as lhp (alternate gene name: cfp10).; lhp, cfp10; 10 kDa culture filtrate antigen EsxB	4352274..4352576	Mycobacterium tuberculosis H37Rv	886194
YP_178023.1	CDS	esxA	NC_000962.2	4352609	4352896	D	Rv3875, (MT3989, MTV027.10), len: 95 aa. esxA, early secretory antigenic target (see citations below), identical to Q57165|O84901|ESAT6 EARLY SECRETORY ANTIGENIC TARGET from Mycobacterium bovis (94 aa), FASTA scores: opt: 596, E(): 4.6e-33, (100.0% identity in 94 aa overlap). Also similar to Q50206|ESA6_MYCLE|ESAT6|ESX|L45|ML0049|MLCB628.12c 6 KDA EARLY SECRETORY ANTIGENIC TARGET HOMOLOG (ESAT-6-LIKE PROTEIN) (L-ESAT) from Mycobacterium leprae (95 aa), FASTA scores: opt: 236, E(): 3.3e-09, (36.25% identity in 91 aa overlap); and weak similarity with others proteins ESAT-like from Mycobacterium leprae. Also some similarity with O53266|ES69_MYCTU|Rv3019c|MT3104|MTV012.33c PUTATIVE SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium tuberculosis (96 aa), FASTA scores: opt: 131, E(): 0.03, (26.15% identity in 88 aa overlap); and other ESAT-like protein. Contains probable coiled-coil from 56 to 92 aa. BELONGS TO THE ESAT6 FAMILY. Note that previously known as esat-6.; esat-6; 6 kDa early secretory antigenic target ESXA (ESAT-6)	4352609..4352896	Mycobacterium tuberculosis H37Rv	886209
NP_218393.1	CDS	Rv3876	NC_000962.2	4353010	4355010	D	Rv3876, (MTV027.11), len: 666 aa. Conserved hypothetical pro-, ala-rich protein, similar to several proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 HYPOTHETICAL PROTEIN (586 aa), FASTA scores: opt: 1682, E(): 2.1e-45, (50.75% identity in 672 aa overlap); O33082|MLCB628.11c HYPOTHETICAL 52.0 KDA PROTEIN (478 aa), FASTA scores: opt: 1588, E(): 1.5e-42, (53.5% identity in 542 aa overlap) (also has a proline rich N-terminus); etc. Also similar to other proteins from Mycobacterium tuberculosis, especially in C-terminus, e.g. O06396|Rv0530|MTCY25D10.09 (405 aa), FASTA scores: opt: 670, E(): 2.5e-14, (34.85% identity in 396 aa overlap) (also has Pro-rich N-terminus); etc. Note that N-terminus is repetitive and highly Proline rich.; hypothetical protein	4353010..4355010	Mycobacterium tuberculosis H37Rv	886206
NP_218394.1	CDS	Rv3877	NC_000962.2	4355007	4356542	D	Rv3877, (MTV027.12), len: 511 aa. Probable conserved transmembrane protein, equivalent to Q9CDD9|ML0047 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (512 aa), FASTA scores: opt: 2496, E(): 2.8e-140, (74.0% identity in 512 aa overlap); and highly similar, but longer 32 aa, to O33081|MLCB628.10c HYPOTHETICAL 51.4 KDA PROTEIN from Mycobacterium leprae (480 aa), FASTA scores: opt: 2346, E(): 2e-131, (74.15% identity in 480 aa overlap). Shows also similarity with other membrane proteins from Mycobacterium leprae e.g. Q9CBV2|ML1539 PROBABLE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 318, E(): 2e-11, (22.7% identity in 520 aa overlap). Also similar to various proteins from Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17 PUTATIVE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 391, E(): 9.4e-16, (24.45% identity in 523 aa overlap); O86362|Rv0290|MTV035.18 HYPOTHETICAL 47.9 KDA PROTEIN (472 aa), FASTA scores: opt: 332, E(): 2.8e-12, (28.1% identity in 509 aa overlap); O05457|Rv3887c|MTCY15F10.25 HYPOTHETICAL 53.2 KDA PROTEIN (509 aa), FASTA scores: opt: 167, E(): 0.017, (24.0% identity in 517 aa overlap); etc. Equivalent to AAK48359 from Mycobacterium tuberculosis strain CDC1551 (479 aa) but longer 32 aa.; transmembrane protein	4355007..4356542	Mycobacterium tuberculosis H37Rv	886207
NP_218395.1	CDS	Rv3878	NC_000962.2	4356693	4357535	D	Rv3878, (MTV027.13), len: 280 aa. Hypothetical unknown ala-rich protein.; hypothetical protein	4356693..4357535	Mycobacterium tuberculosis H37Rv	886198
NP_218396.1	CDS	Rv3879c	NC_000962.2	4357593	4359782	R	Rv3879c, (MTV027.14c), len: 729 aa. Hypothetical unknown ala-, pro-rich protein (N-terminal end is repetitive and highly Proline-rich).; hypothetical protein	complement(4357593..4359782)	Mycobacterium tuberculosis H37Rv	886212
NP_218397.1	CDS	Rv3880c	NC_000962.2	4360199	4360546	R	Rv3880c, (MTV027.15c), len: 115 aa. Conserved hypothetical protein, equivalent to O33080|ML0044|MLCB628.09 HYPOTHETICAL 12.2 KDA PROTEIN from Mycobacterium leprae (113 aa), FASTA scores: opt: 397, E(): 2e-19, (56.35% identity in 110 aa overlap).; hypothetical protein	complement(4360199..4360546)	Mycobacterium tuberculosis H37Rv	886205
NP_218398.1	CDS	Rv3881c	NC_000962.2	4360543	4361925	R	Rv3881c, (MTV027.16c), len: 460 aa. Conserved hypothetical ala-, gly-rich protein. C-terminal end highly similar to O06126 HYPOTHETICAL 9.5 KDA PROTEIN (FRAGMENT) from Mycobacterium tuberculosis strain NTI 64719 (90 aa) FASTA scores: opt: 333, E(): 6.3e-07, (69.75% identity in 86 aa overlap) but sequence difference causes frameshift in NTI 64719. Also similar to part of small Mycobacterium leprae ORF O33078|MLCB628.06 (EMBL:Y14967) (101 aa), FASTA scores: opt: 194, E(): 0.04, (59.3% identity in 54 aa overlap), suggesting this is represented by a pseudogene in Mycobacterium leprae.; hypothetical protein	complement(4360543..4361925)	Mycobacterium tuberculosis H37Rv	886214
NP_218399.1	CDS	Rv3882c	NC_000962.2	4362032	4363420	R	Rv3882c, (MTV027.17c, MTCY15F10.30), len: 462 aa. Possible conserved membrane protein, equivalent to O33077|ML0042|MLCB628.05 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (467 aa), FASTA scores: opt: 2346, E(): 1.1e-140, (72.1% identity in 462 aa overlap). Also similar to O05459|Rv3885c|MTCY15F10.27 POSSIBLE MEMBRANE PROTEIN from Mycobacterium tuberculosis (537 aa) FASTA scores: opt: 283, E(): 2.5e-10, (26.8% identity in 414 aa overlap); and C-terminal end shows similarity with AAK48368|MT4000 HYPOTHETICAL 45.6 KDA PROTEIN from Mycobacterium tuberculosis strain CDC1551 (422 aa) FASTA scores: opt: 215, E(): 4.1e-06, (26.85% identity in 320 aa overlap).; hypothetical protein	complement(4362032..4363420)	Mycobacterium tuberculosis H37Rv	886208
NP_218400.1	CDS	mycP1	NC_000962.2	4363417	4364757	R	Rv3883c, (MTCY15F10.29), len: 446 aa. mycP1, membrane-anchored serine protease (mycosin) (EC 3.4.21.-) (see citations below), equivalent to O33076|ML0041|MLCB628.04 PROBABLE SECRETED PROTEASE from Mycobacterium leprae (446 aa), FASTA scores: opt: 2448, E(): 1.5e-124, (79.15% identity in 446 aa overlap); and highly similar, but in part, to several putative proteases from Mycobacterium leprae; Q9CBV3|ML1538 (567 aa) FASTA scores: opt: 902, E(): 3e-41, (37.25% identity in 556 aa overlap); and Q9CD36|ML2528 (475 aa), FASTA scores: opt: 873, E(): 9.4e-40, (42.7% identity in 459 aa overlap). Shows also similarity with several proteases from other organisms e.g. Q9PCD0|XF1851 SERINE PROTEASE from Xylella fastidiosa (1000 aa), FASTA scores: opt: 281, E(): 1.3e-07, (27.95% identity in 422 aa overlap); P42780|BPRX_BACNO EXTRACELLULAR SUBTILISIN-LIKE PROTEASE PRECURSOR (EC 3.4.21.-) from Bacteroides nodosus (Dichelobacter nodosus) (595 aa), FASTA scores: opt: 270, E(): 3.2e-07, (28.9% identity in 384 aa overlap); Q46541|APRV5 ACIDIC PROTEASE V5 from Bacteroides nodosus (Dichelobacter nodosus) (595 aa), FASTA scores: opt: 264, E(): 6.8e-07, (28.65% identity in 384 aa overlap); etc. Also highly similar to various proteins from Mycobacterium tuberculosis e.g. O53695|Rv0291|MTV035.19 PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (461 aa), FASTA scores: opt: 1168, E(): 1.2e-55, (44.6% identity in 453 aa overlap); O53945|Rv1796|MTV049.18 PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP5 (585 aa), FASTA scores: opt: 928, E(): 1.2e-42, (37.85% identity in 555 aa overlap) (note gap from aa 155-264); and downstream ORF O05458|Rv3886c|MTCY15F10.26 PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP2 (550 aa), FASTA scores: opt: 910, E(): 1.1e-41, (40.15% identity in 533 aa overlap) (note partial gap from aa 146-234); etc. Equivalent to AAK48366 from Mycobacterium tuberculosis strain CDC1551 (411 aa) but longer 35 aa. Has signal sequence with possible signal peptidase I cleavage site in residues 19-21 (ASA) and hydrophobic stretch at C-terminus, followed by short positively charged segment, that seems to act as a membrane anchor. ACTIVATED BY Ca2+ (see Dave et al., 2002). Contains three serine protease, subtilase family active site motifs: a aspartic acid active site motif (PS00136); a histidine active site motif (PS00137); and a serine active site motif (PS00138). BELONGS TO PEPTIDASE FAMILY S8 (ALSO KNOWN AS THE SUBTILASE FAMILY), PYROLYSIN SUBFAMILY.; membrane-anchored mycosin MYCP1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1)	complement(4363417..4364757)	Mycobacterium tuberculosis H37Rv	886217
NP_218401.1	CDS	Rv3884c	NC_000962.2	4364979	4366838	R	Rv3884c, (MTCY15F10.28), len: 619 aa. Probable CBXX/CFQX protein family, similar to hypothetical proteins from Mycobacterium leprae e.g. Q9CD28|Y282_MYCLE|ML2537 (640 aa), FASTA scores: opt: 725, E(): 2.9e-34, (28.95% identity in 587 aa overlap); O33089|Y2G8_MYCLE|ML0055|MLCB628.18c (BELONGS TO THE CBXX/CFQX FAMILY) (573 aa); Q9CBV5|ML1536 (610 aa) FASTA scores: opt: 648, E(): 7.4e-30, (31.5% identity in 549 aa overlap). Also similar to proteins belonging to the CBXX/CFQX FAMILY e.g. Q9RKZ2|SC6D7.05c PUTATIVE CBXX/CFQX FAMILY PROTEIN from Streptomyces coelicolor (618 aa) FASTA scores: opt: 557, E(): 1.3e-24, (28.6% identity in 601 aa overlap); P27643|SP5K_BACSU|SPOVK|SPOVJ STAGE V SPORULATION PROTEIN K from Bacillus subtilis (322 aa) FASTA scores: opt: 485, E(): 1.1e-20, (35.0% identity in 280 aa overlap) (similarity only at C-terminus); Q9KAC6|BH2363 STAGE V SPORULATION PROTEIN K from Bacillus halodurans (315 aa), FASTA scores: opt: 462, E(): 2.2e-19, (36.05% identity in 244 aa overlap) (similarity only at C-terminus); etc. And similar to hypothetical proteins from Mycobacterium tuberculosis belonging to the CBXX/CFQX FAMILY e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10 HYPOTHETICAL 68.1 KDA PROTEIN (631 aa), FASTA scores: opt: 743, E(): 2.6e-35, (29.9% identity in 612 aa overlap); O69733|Y2G8_MYCTU|Rv3868|MT3981|MTV027.03 HYPOTHETICAL 62.4 KDA PROTEIN (573 aa), FASTA scores: opt: 678, E(): 1.3e-31, (31.25% identity in 589 aa overlap); O53947|YH98_MYCTU|Rv1798|MT1847|MTV049.20 (610 aa) FASTA scores: opt: 669, E(): 4.6e-31, (30.95% identity in 549 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). SEEMS TO BELONG TO THE CBXX/CFQX FAMILY.; CBXX/CFQX family protein	complement(4364979..4366838)	Mycobacterium tuberculosis H37Rv	886210
NP_218402.1	CDS	Rv3885c	NC_000962.2	4366908	4368521	R	Rv3885c, (MTCY15F10.27), len: 537 aa. Possible conserved membrane protein (has hydrophobic stretch near N-terminus), showing some similarity with O05462|Rv3882c|MTV027.17c|MTCY15F10.30 POSSIBLE MEMBRANE PROTEIN from Mycobacterium tuberculosis (462 aa) FASTA scores: opt: 283, E(): 8.3e-10, (26.55% identity in 414 aa overlap); and O33077|ML0042|MLCB628.05 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (467 aa), FASTA scores: opt: 260, E(): 2.1e-08, (28.0% identity in 382 aa overlap). Equivalent to AAK48368 from Mycobacterium tuberculosis strain CDC1551 (422 aa) but longer 115 aa.; hypothetical protein	complement(4366908..4368521)	Mycobacterium tuberculosis H37Rv	886220
NP_218403.1	CDS	mycP2	NC_000962.2	4368518	4370170	R	Rv3886c, (MTCY15F10.26), len: 550 aa. Probable mycP2, ala-, pro-rich membrane-anchored serine protease (mycosin) (EC 3.4.21.-) (see citation below), highly similar to Q9CBV3|ML1538 POSSIBLE PROTEASE from Mycobacterium leprae (567 aa), FASTA scores: opt: 1034, E(): 3.9e-32, (43.5% identity in 575 aa overlap); and highly similar, but with gaps, to several putative proteases from Mycobacterium leprae; O33076|ML0041|MLCB628.04 (446 aa), FASTA scores: opt: 860, E(): 1.1e-25, (38.65% identity in 538 aa overlap); Q9CD36|ML2528 (475 aa) (475 aa), FASTA scores: opt: 413, E(): 7.1e-09, (37.7% identity in 562 aa overlap). Also similarity with Q99405|PRTM_BACSP M-PROTEASE (EC 3.4.21.-) from Bacillus sp. strain KSM-K16 (269 aa), FASTA scores: E(): 7.6e-06, (27.1% identity in 277 aa overlap). And highly similar, but also with gaps, to other mycosins from Mycobacterium tuberculosis e.g. O53945|Rv1796|MTV049.18 (585 aa), FASTA scores: opt: 1173, E(): 2.4e-37, (47.9% identity in 578 aa overlap); the upstream ORF O05461|Rv3883c|MTCY15F10.29 (446 aa) FASTA scores: opt: 910, E(): 1.5e-27, (40.15% identity in 533 aa overlap); O06316|Rv3449|MTCY13E12.02 (455 aa) FASTA scores: opt: 477, E(): 2.7e-11, (38.75% identity in 550 aa overlap); etc. Contains Pro rich protein with two serine protease, subtilase family active site motifs: aspartic acid active site motif (PS00136); and histidine active site motif (PS00137). BELONGS TO PEPTIDASE FAMILY S8 (ALSO KNOWN AS THE SUBTILASE FAMILY), PYROLYSIN SUBFAMILY. THOUGHT TO BE CLEAVED INTO SMALLER MOLECULAR WEIGHT PROTEINS, 36 AND 29 KDA (see citation below).; alanine and proline rich membrane-anchored mycosin	complement(4368518..4370170)	Mycobacterium tuberculosis H37Rv	886215
NP_218404.1	CDS	Rv3887c	NC_000962.2	4370155	4371684	R	Rv3887c, (MTCY15F10.25), len: 509 aa. Probable conserved transmembrane protein (has hydrophilic stretch from 1-130 then very hydrophobic domain), similar to other membrane proteins and with weak similarity to known transporters, e.g. Q9CBV2|ML1539 PROBABLE MEMBRANE PROTEIN from Mycobacterium leprae (503 aa), FASTA scores: opt: 395, E(): 2.3e-16, (28.0% identity in 496 aa overlap); Q9CD35|ML2529 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (485 aa), FASTA scores: opt: 221, E(): 6.6e-06, (24.6% identity in 423 aa overlap); Q9ADP8|2SC10A7.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (430 aa), FASTA scores: opt: 171, E(): 0.0062, (26.55% identity in 358 aa overlap); CAC44275|SCBAC17F8.03 PUTATIVE DRUG EFFLUX PROTEIN from Streptomyces coelicolor (416 aa), FASTA scores: opt: 160, E(): 0.028, (27.85% identity in 323 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17 PUTATIVE MEMBRANE PROTEIN (503 aa), FASTA scores: opt: 360, E(): 2.9e-14, (26.65% identity in 514 aa overlap); etc. Equivalent to AAK48369 from Mycobacterium tuberculosis strain CDC1551 (469 aa) but longer 40 aa.; transmembrane protein	complement(4370155..4371684)	Mycobacterium tuberculosis H37Rv	886211
NP_218405.1	CDS	Rv3888c	NC_000962.2	4371681	4372706	R	Rv3888c, (MTCY15F10.24), len: 341 aa. Probable conserved membrane protein, showing similarity with hypothetical proteins from Mycobacterium leprae: O33082|MLCB628.11c (478 aa), FASTA scores: opt: 530, E(): 7.7e-26, (32.45% identity in 336 aa overlap); Q9CDD8|ML0048 (586 aa), FASTA scores: opt: 530, E(): 9.1e-26, (32.45% identity in 336 aa overlap); Q9CCI1|ML0798 (592 aa), FASTA scores: opt: 426, E(): 3e-19, (27.5% identity in 342 aa overlap) (similarity only at C-terminus). Also similar to proteins from Mycobacterium tuberculosis e.g. P96217|Rv3860|MTCY01A6.08c (390 aa), FASTA scores: opt: 603, E(): 1.7e-30, (35.2% identity in 284 aa overlap); O06396|Rv0530|MTCY25D10.09 (405 aa), FASTA scores: opt: 573, E(): 1.3e-28, (32.0% identity in 328 aa overlap); C-terminus of O69740|Rv3876|MTV027.1 (666 aa), FASTA scores: opt: 509, E(): 2.1e-24, (31.0% identity in 303 aa overlap); etc.; hypothetical protein	complement(4371681..4372706)	Mycobacterium tuberculosis H37Rv	886219
NP_218406.1	CDS	Rv3889c	NC_000962.2	4372800	4373630	R	Rv3889c, (MTCY15F10.23), len: 276 aa. Hypothetical unknown protein.; hypothetical protein	complement(4372800..4373630)	Mycobacterium tuberculosis H37Rv	886223
NP_218407.1	CDS	esxC	NC_000962.2	4373726	4374013	R	Rv3890c, (MT4005, MTCY15F10.22), len: 95 aa. esxC, ESAT-6 like protein (see Gey Van Pittius et al., 2001), equivalent to Q9K548|ES6B_MYCPA PUTATIVE ESAT-6 LIKE PROTEIN 11 (ORF3890C) from Mycobacterium paratuberculosis (95 aa), FASTA scores: opt: 490, E(): 3.3e-26, (76.85% identity in 95 aa overlap). BELONGS TO THE ESAT6 FAMILY.; ES6_11; ESAT-6 like protein ESXC (ESAT-6 like protein 11)	complement(4373726..4374013)	Mycobacterium tuberculosis H37Rv	886222
NP_218408.1	CDS	esxD	NC_000962.2	4374049	4374372	R	Rv3891c, (MTCY15F10.21), len: 107 aa (first GTG taken). esxD, ESAT-6 like protein, equivalent to Q9K547 HYPOTHETICAL 10.3 KDA PROTEIN (FRAGMENT) from Mycobacterium paratuberculosis (100 aa), FASTA scores: opt: 498, E(): 1.7e-26, (77.25% identity in 101 aa overlap). SEEMS TO BELONG TO THE ESAT6 FAMILY (see Gey Van Pittius et al., 2001).; ESAT-6 like protein EsxD	complement(4374049..4374372)	Mycobacterium tuberculosis H37Rv	886218
YP_178024.1	CDS	PPE69	NC_000962.2	4374484	4375683	R	Rv3892c, (MTCY15F10.20), len: 399 aa. Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348, E(): 2.2e-08, (26.6% identity in 380 aa overlap).; PPE family protein	complement(4374484..4375683)	Mycobacterium tuberculosis H37Rv	886227
YP_178025.1	CDS	PE36	NC_000962.2	4375762	4375995	R	Rv3893c, (MTCY15F10.19), len: 77 aa. Member of the Mycobacterium tuberculosis PE family of conserved proteins (see citation below), similar to others e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap).; PE family protein	complement(4375762..4375995)	Mycobacterium tuberculosis H37Rv	886213
NP_218411.1	CDS	Rv3894c	NC_000962.2	4376262	4380452	R	Rv3894c, (MTCY15F10.18), len: 1396 aa. Possible conserved membrane protein (possible transmembrane segments from aa 37-85), similar to Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa), FASTA scores: opt: 652, E(): 2.2e-30, (27.85% identity in 1425 aa overlap); Q9CDD7|ML0052 HYPOTHETICAL PROTEIN from Mycobacterium leprae (597 aa), FASTA scores: opt: 537, E(): 6.6e-24, (27.5% identity in 585 aa overlap) (similarity only with C-terminal end); Q9Z5I2|ML1543|MLCB596.28 POSSIBLE SPOIIIE-FAMILY MEMBRANE PROTEIN from Mycobacterium leprae (1345 aa), FASTA scores: opt: 523, E(): 8.6e-23, (31.65% identity in 1412 aa overlap). Also similar to various proteins e.g. O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 973, E(): 2.8e-49, (28.1% identity in 1409 aa); Q9L0T6|SCD35.15c PUTATIVE CELL DIVISION-RELATED PROTEIN from Streptomyces coelicolor(1525 aa), FASTA scores: opt: 524, E(): 8.3e-23, (24.95% identity in 1450 aa overlap); Q9KE81|BH0975 HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa), FASTA scores: opt: 444, E(): 4.1e-18, (22.5% identity in 1346 aa overlap); etc. Also similar to AAK46103|MT1833 FTSK/SPOIIIE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (1391 aa), FASTA scores: opt: 769, E(): 2.9e-37, (30.6% identity in 1434 aa overlap); and other hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 634, E(): 2.5e-29, (28.2% identity in 1443 aa overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt: 632, E(): 3.1e-29, (28.75% identity in 1391 aa overlap); O69736|R3871|MTV027.06 (591 aa), FASTA scores: opt: 588, E(): 6.6e-27, (27.75% identity in 605 aa overlap) (similarity only with C-terminal end); etc. Contains two possible (PS00017) ATP/GTP-binding sites (P-loop) in central portion.; hypothetical protein	complement(4376262..4380452)	Mycobacterium tuberculosis H37Rv	886230
NP_218412.1	CDS	Rv3895c	NC_000962.2	4380453	4381940	R	Rv3895c, (MTCY15F10.17), len: 495 aa. Probable conserved membrane protein, highly similar to two CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae: Q9Z5I3|ML1544|MLCB596.27 (506 aa), FASTA scores: opt: 1070, E(): 1.4e-53, (39.8% identity in 485 aa overlap); and Q9CD29|ML2536 (552 aa), FASTA scores: opt: 483, E(): 4e-20, (36.85% identity in 499 aa overlap). Also highly similar to various proteins from Mycobacterium tuberculosis e.g. O53933|Rv1782|MTV049.04 HYPOTHETICAL PROTEIN (506 aa), FASTA scores: opt: 1106, E(): 1.2e-55, (41.25% identity in 485 aa overlap); O69734|Rv3869|MTV027.04 HYPOTHETICAL PROTEIN (480 aa), FASTA scores: opt: 795, E(): 6.1e-38, (36.0% identity in 486 aa overlap); O33088|ML0054|MLCB628.17c PUTATIVE MEMBRANE PROTEIN) (481 aa), FASTA scores: opt: 740, E(): 8.3e-35, (35.65% identity in 485 aa overlap); etc.; hypothetical protein	complement(4380453..4381940)	Mycobacterium tuberculosis H37Rv	886231
NP_218413.1	CDS	Rv3896c	NC_000962.2	4381943	4382851	R	Rv3896c, (MTCY15F10.16), len: 302 aa (first GTG taken, although TBparse suggests TTG at 16079). Putative conserved ala-rich protein. C-terminus highly similar to C-terminal end of other proteins e.g. Q9XAS4|SC10A7.01 HYPOTHETICAL 17.2 KDA PROTEIN from Streptomyces coelicolor (244 aa), FASTA scores: opt: 255, E(): 1.4e-08, (32.0% identity in 222 aa overlap); CAC44611|STBAC16H6.32 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (172 aa), FASTA scores: opt: 214, E(): 3.4e-06, (42.55% identity in 94 aa overlap); Q38352|ORF360 from Lactococcus delbrueckii bacteriophage LL-H (360 aa), FASTA scores: opt: 211, E(): 9.5e-06, (40.0% identity in 115 aa overlap); P54334|XKDO_BACSU|XKDO PHAGE-LIKE ELEMENT PBSX PROTEIN from Bacillus subtilis (1332 aa), FASTA scores: opt: 209, E(): 3.6e-05, (38.35% identity in 86 aa overlap); etc. Also similar to P71594|P71594|Rv0024|MTCY10H4.24 HYPOTHETICAL 30.3 KDA PROTEIN from Mycobacterium tuberculosis (281 aa), FASTA scores: opt: 265, E(): 3.9e-09, (29.25% identity in 287 aa overlap).; hypothetical protein	complement(4381943..4382851)	Mycobacterium tuberculosis H37Rv	886216
NP_218414.1	CDS	Rv3897c	NC_000962.2	4383008	4383640	R	Rv3897c, (MTCY15F10.15), len: 210 aa. Conserved hypothetical protein, highly similar in part to Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 HYPOTHETICAL 30.8 KDA PROTEIN from Mycobacterium tuberculosis (314 aa) FASTA scores: opt: 815, E(): 4.7e-26, (73.05% identity in 167 aa overlap). Similarity to MTCY49.22 suggests that this is a continuation of MTCY15F10.14. There is a frameshift mutation near 3'-end with respect to this sequence as well, similarity to MTCY49.22 continues in an overlapping ORF. Sequence appears to be correct.; hypothetical protein	complement(4383008..4383640)	Mycobacterium tuberculosis H37Rv	886225
NP_218415.1	CDS	Rv3898c	NC_000962.2	4383653	4383985	R	Rv3898c, (MTCY15F10.14), len: 110 aa. Conserved hypothetical protein. Highly similar, but in part, to Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 HYPOTHETICAL 30.8 KDA PROTEIN from Mycobacterium tuberculosis (314 aa) FASTA scores: opt: 204, E(): 0.00042, (50.6% identity in 81 aa overlap). Similarity suggests it should be in frame with next ORF and that the stop codon could be read through, the sequence appears to be correct. Homology lost upstream at 15138 gatc sequence may suggest discontinuity due to chimerism in cY15F10 or cY49.; hypothetical protein	complement(4383653..4383985)	Mycobacterium tuberculosis H37Rv	886233
NP_218416.1	CDS	Rv3899c	NC_000962.2	4384147	4385379	R	Rv3899c, (MTCY15F10.13), len: 410 aa. Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 HYPOTHETICAL 15.1 KDA PROTEIN (FRAGMENT) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 HYPOTHETICAL 13.7 KDA PROTEIN (FRAGMENT) (143 aa), FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN (721 aa), FASTA scores: opt: 1388, E(): 1.5e-48, (55.25% identity in 409 aa overlap). And similar to P71599|Rv0029|MTCY10H4.29 HYPOTHETICAL 39.6 KDA PROTEIN (365 aa), FASTA scores: opt: 403, E(): 1.7e-09, (33.75% identity in 252 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct.; hypothetical protein	complement(4384147..4385379)	Mycobacterium tuberculosis H37Rv	886228
NP_218417.1	CDS	Rv3900c	NC_000962.2	4385373	4386308	R	Rv3900c, (MTCY15F10.12), len: 311 aa. Conserved hypothetical ala-rich protein, highly similar to N-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN from Mycobacterium tuberculosis (721 aa), FASTA scores: opt: 592, E(): 2.7e-22, (37.15% identity in 280 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct.; hypothetical protein	complement(4385373..4386308)	Mycobacterium tuberculosis H37Rv	886235
NP_218418.1	CDS	Rv3901c	NC_000962.2	4386365	4386814	R	Rv3901c, (MTCY15F10.11), len: 149 aa. Possible membrane protein (hydrophobic stretch from 30-52), showing some similarity with O53200|Rv2473|MTV008.29 HYPOTHETICAL 25.1 KDA PROTEIN from Mycobacterium tuberculosis (238 aa), FASTA scores: opt: 147, E(): 0.036, (31.35% identity in 134 aa overlap).; hypothetical protein	complement(4386365..4386814)	Mycobacterium tuberculosis H37Rv	886226
NP_218419.1	CDS	Rv3902c	NC_000962.2	4387365	4387895	R	Rv3902c, (MTCY15F10.10), len: 176 aa. Hypothetical unknown protein.; hypothetical protein	complement(4387365..4387895)	Mycobacterium tuberculosis H37Rv	886236
NP_218420.1	CDS	Rv3903c	NC_000962.2	4387892	4390432	R	Rv3903c, (MTCY15F10.08), len: 846 aa. Hypothetical unknown ala-, pro-rich protein.; hypothetical protein	complement(4387892..4390432)	Mycobacterium tuberculosis H37Rv	886229
NP_218421.1	CDS	esxE	NC_000962.2	4390437	4390709	R	Rv3904c, (MT4023, MTCY15F10.07), len: 90 aa. esxE, ESAT-6 like protein, hypothetical unknown ala-rich protein. BELONGS TO THE ESAT6 FAMILY (see citation below).; ES6_12; hypothetical protein	complement(4390437..4390709)	Mycobacterium tuberculosis H37Rv	886237
NP_218422.1	CDS	esxF	NC_000962.2	4390720	4391031	R	Rv3905c, (MT4024, MTCY15F10.06), len: 103 aa. esxF, ESAT-6 like protein (see citation below), hypothetical unknown ala-, gly-rich protein, ESAT-6 like protein. BELONGS TO THE ESAT6 FAMILY.; ES6_13; hypothetical protein	complement(4390720..4391031)	Mycobacterium tuberculosis H37Rv	886239
NP_218423.1	CDS	Rv3906c	NC_000962.2	4391097	4391606	R	Rv3906c, (MTCY15F10.05), len: 169 aa. Conserved hypothetical protein, strongly related to Q50578|AT9S (SOD related in Escherichia coli) from Mycobacterium tuberculosis strain AOYAMA B (155 aa), but apparently different as flanking sequences differ and shorter 43 aa, FASTA scores: opt: 548, E(): 1.3e-26, (79.4% identity in 102 aa overlap). Selfmarch results suggest that Rv3906c is not related to any other hypothetical protein from Mycobacterium tuberculosis strain H37Rv except itself. Shows also similarity with Q9VFR2|CG9297 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (930 aa), FASTA scores: opt: 221, E(): 4.9e-06, (36.95% identity in 157 aa overlap); Q9HQ55|CBP|VNG1320G CALCIUM-BINDING PROTEIN HOMOLOGY from Halobacterium sp. strain NRC-1 (385 aa) FASTA scores: opt: 143, E(): 0.13, (35.65% identity in 160 aa overlap); Q24795 CALCIUM-BINDING PROTEIN (FRAGMENT) from Echinococcus granulosus (338 aa), FASTA scores: opt: 140, E(): 0.17, (33.95% identity in 156 aa overlap).; hypothetical protein	complement(4391097..4391606)	Mycobacterium tuberculosis H37Rv	886221
YP_178026.1	CDS	pcnA	NC_000962.2	4391631	4393073	R	Rv3907c, (MTCY15F10.04), len: 480 aa. Probable pcnA, polynucleotide polymerase (EC 2.7.7.19), equivalent to Q9CCY1|PCNA|ML2697 PCNA PROTEIN from Mycobacterium leprae (486 aa), FASTA scores: opt: 2713, E(): 4.3e-160, (84.1% identity in 478 aa overlap); and Q59534|PCNB POLYA POLYMERASE from Mycobacterium leprae (411 aa) FASTA scores: opt: 2077, E(): 7.1e-121, (82.55% identity in 373 aa overlap). Also highly similar to many e.g. Q9X8T2|SCH24.18 PUTATIVE RNA NUCLEOTIDYLTRANSFERASE from Streptomyces coelicolor (483 aa), FASTA scores: opt: 1856, E(): 3.7e-107, (61.55% identity in 455 aa overlap); Q9ZN65 POLYA POLYMERASE from Prevotella ruminicola (Bacteroides ruminicola) (479 aa), FASTA scores: opt: 830, E(): 8.5e-44, (34.85% identity in 445 aa overlap); P42977|PAPS_BACSU POLY(A) POLYMERASE from Bacillus subtilis (397 aa), FASTA scores: opt: 479, E(): 3.5e-22, (29.35% identity in 450 aa overlap); etc. Contains: PS00017 ATP/GTP-binding site motif A (P-loop), PS00018 EF-hand calcium-binding domain, and probably less significant a PS00237 G-protein coupled receptor signature, and PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. BELONGS TO THE TRNA NUCLEOTIDYLTRANSFERASE / POLY(A) POLYMERASE FAMILY.; poly(A) polymerase	complement(4391631..4393073)	Mycobacterium tuberculosis H37Rv	886240
NP_218425.1	CDS	Rv3908	NC_000962.2	4393449	4394195	D	Rv3908, (MTCY15F10.03c), len: 248 aa. Conserved hypothetical protein, equivalent to Q50195|ML2698|L222-ORF6 HYPOTHETICAL PROTEIN from Mycobacterium leprae (251 aa), FASTA scores: opt: 1270, E(): 3.4e-62, (79.05% identity in 248 aa overlap). Also similar to O66548|APFA|AQ_158 HYDROLASE from Aquifex aeolicus (134 aa), FASTA scores: opt: 300, E(): 1.1e-09, (37.3% identity in 142 aa overlap); and similarity with other various proteins e.g. O93721 DIADENOSINE 5'5'''-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE from Pyrobaculum aerophilum (143 aa), FASTA scores: opt: 205, E(): 0.00017, (34.85% identity in 109 aa overlap); Q9HS29|APA|VNG0431G DIADENOSINE TETRAPHOSPHATE PYROPHOSPHOHYDROLASE from Halobacterium sp. strain NRC-1 (142 aa), FASTA scores: opt: 199, E(): 0.00036, (34.0% identity in 147 aa overlap); Q9YA58|APE2080 HYPOTHETICAL 19.2 KDA PROTEIN from Aeropyrum pernix (175 aa) FASTA scores: opt: 191, E(): 0.0012, (36.9% identity in 141 aa overlap); etc. Also similar to P95110|MUTT1|Rv2985|MTCY349.02 HYPOTHETICAL 34.7 KDA PROTEIN from Mycobacterium tuberculosis (317 aa) FASTA scores: opt: 224, E(): 3e-05, (34.05% identity in 144 aa overlap).; hypothetical protein	4393449..4394195	Mycobacterium tuberculosis H37Rv	886242
NP_218426.1	CDS	Rv3909	NC_000962.2	4394192	4396600	D	Rv3909, (MTCY15F10.02c), len: 802 aa. Conserved hypothetical protein, equivalent to Q9CCY0|ML2699 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (797 aa) FASTA scores: opt: 3777, E(): 8.8e-206, (72.35% identity in 803 aa overlap). Note that the N-terminal end is highly similar to Q50196|L222-ORF7 (286 aa), FASTA scores: opt: 1213, E(): 2.7e-61, (71.75% identity in 255 aa overlap); and the C-terminal end is highly similar to Q50197|L222-ORF8 also from Mycobacterium leprae (512 aa) FASTA scores: opt: 2375, E(): 9.9e-127, (71.8% identity in 518 aa overlap). Shows some similarity with N-terminal end of Q9I2M3|PA1874 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (2468 aa), FASTA scores: opt: 171, E(): 0.13, (22.9% identity in 672 aa overlap).; hypothetical protein	4394192..4396600	Mycobacterium tuberculosis H37Rv	886245
NP_218427.1	CDS	Rv3910	NC_000962.2	4396597	4400151	D	Rv3910, (MTCY15F10.01c.MTV028.01), len: 1184 aa. Probable conserved transmembrane protein (hydrophobic domain 50-550), equivalent to Q9CCX9|ML2700 POSSIBLE CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (1206 aa), FASTA scores: opt: 5554, E(): 0, (75.15% identity in 1182 aa overlap); and highly similar, but shorter 380 aa, to Q50199|L222-ORF10 from Mycobacterium leprae (784 aa) FASTA scores: opt: 3297, E(): 5.5e-170, (68.8% identity in 769 aa overlap); and at the N-terminal end with Q50198|L222-ORF also from Mycobacterium leprae (379 aa) FASTA scores: opt: 1955, E(): 5.7e-98, (88.4% identity in 353 aa overlap) (ORFs 9 and 10 are adjacent on L222). Also similar in part (principally at the N-terminal end) to other membrane proteins e.g. Q9X8T0|SCH24.16c PUTATIVE TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (811 aa), FASTA scores: opt: 573, E(): 2.8e-23, (31.05% identity in 573 aa overlap); O05467|MVIN_RHITR INTEGRAL MEMBRANE PROTEIN VIRULENCE FACTOR MVIN HOMOLOG from Rhizobium tropici (533 aa), FASTA scores: opt: 468, E(): 9e-18, (27.1% identity in 524 aa overlap); P56882|MVIN_RHIME INTEGRAL MEMBRANE PROTEIN VIRULENCE FACTOR MVIN HOMOLOG from Rhizobium meliloti (Sinorhizobium meliloti) (535 aa), FASTA scores: opt: 453, E(): 5.8e-17, (26.2% identity in 557 aa overlap); etc.; transmembrane protein	4396597..4400151	Mycobacterium tuberculosis H37Rv	886247
NP_218428.1	CDS	sigM	NC_000962.2	4400186	4400854	D	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM	4400186..4400854	Mycobacterium tuberculosis H37Rv	886246
NP_218429.1	CDS	Rv3912	NC_000962.2	4400870	4401634	D	Rv3912, (MTV008.03), len: 254 aa. Hypothetical unknown ala-rich protein.; hypothetical protein	4400870..4401634	Mycobacterium tuberculosis H37Rv	886234
NP_218430.1	CDS	trxB2	NC_000962.2	4401728	4402735	D	Rv3913, (MT4032, MTV028.04), len: 335 aa. Probable trxB2, thioredoxin reductase (EC 1.6.4.5) (see citation below), equivalent to O30973|TRXB_MYCSM THIOREDOXIN REDUCTASE from Mycobacterium smegmatis (311 aa), FASTA scores: opt: 1575, E(): 1.8e-87, (78.35% identity in 305 aa overlap); and highly similar, but shorter at C-terminus, to P46843|TRXB_MYCLE|TRXB/A|TRX|ML2703 BIFUNCTIONAL THIOREDOXIN REDUCTASE/THIOREDOXIN from Mycobacterium leprae (458 aa), FASTA scores: opt: 1766, E(): 8.7e-99, (83.25% identity in 328 aa overlap). Also highly similar to many e.g. P52215|TRXB_STRCO|SCH24.12 from Streptomyces coelicolor (321 aa), FASTA scores: opt: 1249, E(): 7.2e-68, (60.4% identity in 313 aa overlap); Q9Z8M4|TRXB_CHLPN from Chlamydia pneumoniae (Chlamydophila pneumoniae) (311 aa), FASTA scores: opt: 978, E(): 1.3e-51, (49.85% identity in 307 aa overlap); P09625|TRXB_ECOLI|B0888 from Escherichia coli strain K12 (320 aa), FASTA scores: opt: 948, E(): 8.6e-50, (49.2% identity in 309 aa overlap); etc. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-II. COFACTOR: FAD (BY SIMILARITY).; thioredoxin reductase TRXB2	4401728..4402735	Mycobacterium tuberculosis H37Rv	886232
NP_218431.1	CDS	trxC	NC_000962.2	4402732	4403082	D	Rv3914, (MT4033, MTV028.05), len: 116 aa. trxC (alternate gene names: mpt46, trx, trxA *), thioredoxin (EC 1.-.-.-) (see citations below), equivalent to O30974|THIO_MYCSM|TRXA THIOREDOXIN from Mycobacterium smegmatis (112 aa), FASTA scores: opt: 576, E(): 2.1e-32, (80.2% identity in 111 aa overlap); and also equivalent to C-terminal end of P46843|TRXB_MYCLE|TRXB/A|TRX|ML2703 BIFUNCTIONAL THIOREDOXIN REDUCTASE/THIOREDOXIN from Mycobacterium leprae (458 aa), FASTA scores: opt: 628, E(): E(): 2e-35, (82.9% identity in 117 aa overlap). Also highly similar to many e.g. P80579|THIO_ALIAC from Alicyclobacillus acidocaldarius (Bacillus acidocaldarius) (105 aa), FASTA scores: opt: 411, E(): 3e-21, (57.15% identity in 105 aa overlap); P00275|THI1_CORNE from Corynebacterium nephridii (105 aa), FASTA scores: opt: 394, E(): 4.3e-20, (56.7% identity in 97 aa overlap); P00274|THIO_ECOLI|TRXA|TSNC|FIPA|B3781 from Escherichia coli and Salmonella typhimurium strain K12 and LT2 respectively (108 aa), FASTA scores: opt: 364, E(): 4.7e-18, (54.45% identity in 101 aa overlap); etc. Also similar to O53162|TRXB|Rv1471|MTV007.18 THIOREDOXIN from Mycobacterium tuberculosis (123 aa), FASTA scores: E(): 2.3e-15, (41.9% identity in 93 aa overlap). Contains PS00194 Thioredoxin family active site. BELONGS TO THE THIOREDOXIN FAMILY. The product of this CDS is supposed secreted. In this cas, this protein could exert its free radical scavenging activity inside macrophages. (*) Warning: note that Rv1470|MTV007.17 correspond also to trxA.; trx; trxA; mpt46; thioredoxin trxC (TRX) (MPT46)	4402732..4403082	Mycobacterium tuberculosis H37Rv	886241
YP_178027.1	CDS	Rv3915	NC_000962.2	4403192	4404412	D	Rv3915, (MTV028.06), len: 406 aa. Probable hydrolase (EC 3.-.-.-), equivalent to Q9CCX8|ML2704 PUTATIVE HYDROLASE from Mycobacterium leprae (406 aa) FASTA scores: opt: 2341, E(): 2.7e-138, (86.95% identity in 406 aa overlap); the N-terminal end is highly similar to Q59535 N-ACETYMURAMYL-L-ALANINE AMIDASE (EC 3.5.1.28) from Mycobacterium leprae (205 aa), FASTA scores: opt: 1046, E(): 5.7e-58, (84.85% identity in 185 aa overlap). Also similar to other hydrolases (especially amidases (EC 3.5.-.-)) e.g. C-terminal end of Q9K6R3|LYTC|BH3665 N-ACETYLMURAMOYL-L-ALANINE AMIDASE (MAJOR AUTOLYSIN) from Bacillus halodurans (588 aa), FASTA scores: opt: 363, E(): 4.3e-15, (33.15% identity in 356 aa overlap); Q9PKC7|TC0539 PUTATIVE N-ACETYLMURAMOYL-L-ALANINE AMIDASE from Chlamydia muridarum (268 aa), FASTA scores: opt: 285, E(): 1.6e-10, (26.05% identity in 242 aa overlap) (RV3915 product appears longer 127 aa); Q9S596|PDCA PENICILLIN-RESISTANT DD-CARBOXYPEPTIDASE (EC 3.4.-.-) from Myxococcus xanthus (302 aa), FASTA scores: opt: 270, E(): 1.5e-09, (39.85% identity in 158 aa overlap); etc. Note that previously known as cwlM.; cwlM; hydrolase	4403192..4404412	Mycobacterium tuberculosis H37Rv	886250
NP_218433.1	CDS	Rv3916c	NC_000962.2	4404433	4405167	R	Rv3916c, (MTV028.07c), len: 244 aa. Conserved hypothetical protein, equivalent to Q50200|ML2705|L222-ORF1 HYPOTHETICAL PROTEIN from Mycobacterium leprae (259 aa), FASTA scores: opt: 1266, E(): 2e-74, (76.4% identity in 250 aa overlap). Also highly similar (but with gaps) to Q9R3S2|STH24.10 HYPOTHETICAL 22.6 KDA PROTEIN from Streptomyces coelicolor (205 aa), FASTA scores: opt: 387, E(): 7.5e-18, (40.25% identity in 231 aa overlap).; hypothetical protein	complement(4404433..4405167)	Mycobacterium tuberculosis H37Rv	886249
NP_218435.2	CDS	parB	NC_000962.2	4405457	4406491	R	Rv3917c, (MTV028.08c, MT4036), len: 344 aa. Probable parB, chromosome partitioning protein, equivalent to Q50201|PARB_MYCLE|ML2706 PROBABLE CHROMOSOME PARTITIONING PROTEIN from Mycobacterium leprae (333 aa), FASTA scores: opt: 1654, E(): 1.6e-88, (78.6% identity in 332 aa overlap). Also highly similar to to others e.g. Q9S6U1|STH24.09 PUTATIVE PARTITIONING OR SPORULATION PROTEIN from Streptomyces coelicolor (328 aa), FASTA scores: opt: 966, E(): 9.7e-49, (58.55% identity in 287 aa overlap) (no similarity on N-terminus); Q9PB63|PARB_XYLFA|XF2281 PROBABLE CHROMOSOME PARTITIONING PROTEIN from Xylella fastidiosa (310 aa), FASTA scores: opt: 598, E(): 1.8e-27, (38.65% identity in 326 aa overlap); P31857|PARB_PSEPU PROBABLE CHROMOSOME PARTITIONING PROTEIN from Pseudomonas putida (290 aa), FASTA scores: opt: 573, E(): 4.6e-26, (40.35% identity in 322 aa overlap); etc. Contains probable helix-turn-helix motif at aa 179 to 200 (Score 1150, +3.1 0 SD). BELONGS TO THE PARB FAMILY. Note that previously known as parA.; parA; chromosome partitioning protein ParB	complement(4405457..4406491)	Mycobacterium tuberculosis H37Rv	886244
NP_218434.2	CDS	parA	NC_000962.2	4406488	4407531	R	Rv3918c, (MTV028.09c), len: 347 aa. Probable parA, chromosome partitioning protein, highly similar to Q9CCX7|PARA|ML2707 PUTATIVE CELL DIVISION PROTEIN from Mycobacterium leprae (351 aa), FASTA scores: opt: 1679, E(): 2.9e-93, (78.1% identity in 347 aa overlap). Also highly similar to others e.g. Q9RFM1|PARA PARA PROTEIN from Streptomyces coelicolor (357 aa), FASTA scores: opt: 1197, E(): 2e-64, (60.45% identity in 306 aa overlap); Q98DZ3|MLL4479|PARA CHROMOSOME PARTITIONING PROTEIN from Rhizobium loti (Mesorhizobium loti) (266 aa), FASTA scores: opt: 835, E(): 7.2e-43, (50.95% identity in 257 aa overlap); O05189|PARA_CAUCR CHROMOSOME PARTITIONING PROTEIN from Caulobacter crescentus (267 aa), FASTA scores: opt: 813, E(): 1.5e-41, (51.35% identity in 261 aa overlap) (has its N-terminus shorter); etc. Equivalent to AAK48403 from Mycobacterium tuberculosis strain CDC1551 (381 aa) but shorter 34 aa. Also similar to other Mycobacterium tuberculosis proteins: MTCI125.30, FASTA scores: E(): 4.3e-32, (35.2% identity in 327 aa overlap); and MTCY07D11.13, FASTA scores: E(): 3e-30, (39.9% identity in 263 aa overlap). BELONGS TO THE PARA FAMILY. Possible alternative start site at aa 107. Note that previously known as parB.; parB; chromosome partitioning protein ParA	complement(4406488..4407531)	Mycobacterium tuberculosis H37Rv	886224
NP_218436.1	CDS	gidB	NC_000962.2	4407528	4408202	R	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB	complement(4407528..4408202)	Mycobacterium tuberculosis H37Rv	886243
NP_218437.1	CDS	Rv3920c	NC_000962.2	4408334	4408897	R	Rv3920c, (MTV028.11c), len: 187 aa. Hypothetical protein, similar to JAG protein, equivalent to Q9L7M2 HYPOTHETICAL 20.1 KDA PROTEIN from Mycobacterium paratuberculosis (183 aa), FASTA scores: opt: 1004, E(): 7.3e-52, (85.05% identity in 187 aa overlap); and Q50204|ML2709 HYPOTHETICAL PROTEIN SIMILAR TO JAG PROTEIN SPOIIIJ ASSOCIATED PROTEIN IN BACILLUS SUBTILIS from Mycobacterium leprae (193 aa), FASTA scores: opt: 871, E(): 4.4e-44, (73.05% identity in 193 aa overlap). Also similar to other bacterial proteins e.g. O54595|STH24.06|JAG JAG-LIKE PROTEIN from Streptomyces coelicolor (170 aa), FASTA scores: opt: 593, E(): 6.7e-28, (62.85% identity in 167 aa overlap); Q9RCA6|JAG|BH4063 JAG PROTEIN HOMOLOG from Bacillus halodurans (207 aa), FASTA scores: opt: 282, E(): 1.1e-09, (35.0% identity in 140 aa overlap); Q9X1H1|TM1460 PUTATIVE JAG PROTEIN, PUTATIVE from Thermotoga maritima (221 aa), FASTA scores: opt: 258, E(): 3e-08, (31.9% identity in 138 aa overlap);Q01620|JAG_BACSU JAG PROTEIN (SPOIIIJ ASSOCIATED PROTEIN) from Bacillus subtilis (208 aa), FASTA scores: opt: 196, E(): 0.00012, (28.05% identity in 139 aa overlap); etc.; hypothetical protein	complement(4408334..4408897)	Mycobacterium tuberculosis H37Rv	886255
NP_218438.1	CDS	Rv3921c	NC_000962.2	4408969	4410069	R	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC	complement(4408969..4410069)	Mycobacterium tuberculosis H37Rv	886238
NP_218439.1	CDS	Rv3922c	NC_000962.2	4410053	4410415	R	Rv3922c, (MTV028.13c), len: 120 aa. Possible hemolysin, highly similar to Q9L7M0|YIDD_MYCPA HYPOTHETICAL 12.4 KDA PROTEIN from Mycobacterium paratuberculosis (115 aa), FASTA scores: opt: 521, E(): 1.9e-29, (65.2% identity in 112 aa overlap). Also highly similar to Q44066|HLYA_AERHY PUTATIVE ALPHA-HEMOLYSIN from Aeromonas hydrophila (85 aa), FASTA scores: opt: 276, E(): 1.5e-12, (51.45% identity in 70 aa overlap); and to many bacterial hypothetical proteins from bacterium e.g. P22847|YIDD_ECOLI|B3704.1 HYPOTHETICAL PROTEIN from Escherichia coli strain K12 (85 aa), FASTA scores: opt: 276, E(): 1.5e-12, (51.45% identity in 70 aa overlap).; hypothetical protein	complement(4410053..4410415)	Mycobacterium tuberculosis H37Rv	886256
NP_218440.2	CDS	rnpA	NC_000962.2	4410412	4410762	R	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P	complement(4410412..4410762)	Mycobacterium tuberculosis H37Rv	886248
NP_218441.1	CDS	rpmH	NC_000962.2	4410786	4410929	R	in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34	complement(4410786..4410929)	Mycobacterium tuberculosis H37Rv	886258
Rvnt01	tRNA	Rvnt01	NC_000962.2	10887	10960	D	tRNA-Ile	10887..10960	Mycobacterium tuberculosis H37Rv	2700464
Rvnt02	tRNA	Rvnt02	NC_000962.2	11112	11184	D	tRNA-Ala	11112..11184	Mycobacterium tuberculosis H37Rv	2700469
Rvnt03	tRNA	Rvnt03	NC_000962.2	25644	25726	D	tRNA-Leu	25644..25726	Mycobacterium tuberculosis H37Rv	2700444
Rvnt04	tRNA	Rvnt04	NC_000962.2	386204	386274	R	tRNA-Gly	complement(386204..386274)	Mycobacterium tuberculosis H37Rv	2700441
Rvnt05	tRNA	Rvnt05	NC_000962.2	658109	658189	D	tRNA-Tyr	658109..658189	Mycobacterium tuberculosis H37Rv	2700426
Rvnt06	tRNA	Rvnt06	NC_000962.2	731494	731566	D	tRNA-Thr	731494..731566	Mycobacterium tuberculosis H37Rv	2700463
Rvnt07	tRNA	Rvnt07	NC_000962.2	731603	731676	D	tRNA-Met	731603..731676	Mycobacterium tuberculosis H37Rv	2700431
Rvnt08	tRNA	Rvnt08	NC_000962.2	733524	733596	D	tRNA-Trp	733524..733596	Mycobacterium tuberculosis H37Rv	2700453
Rvnt09	tRNA	Rvnt09	NC_000962.2	850642	850713	R	tRNA-Thr	complement(850642..850713)	Mycobacterium tuberculosis H37Rv	2700448
Rvnt10	tRNA	Rvnt10	NC_000962.2	923803	923875	R	tRNA-Lys	complement(923803..923875)	Mycobacterium tuberculosis H37Rv	2700435
Rvnt11	tRNA	Rvnt11	NC_000962.2	923999	924072	D	tRNA-Glu	923999..924072	Mycobacterium tuberculosis H37Rv	2700445
Rvnt12	tRNA	Rvnt12	NC_000962.2	924110	924183	D	tRNA-Asp	924110..924183	Mycobacterium tuberculosis H37Rv	2700454
Rvnt13	tRNA	Rvnt13	NC_000962.2	924213	924286	D	tRNA-Phe	924213..924286	Mycobacterium tuberculosis H37Rv	2700446
Rvnt14	tRNA	Rvnt14	NC_000962.2	1025321	1025393	R	tRNA-Arg	complement(1025321..1025393)	Mycobacterium tuberculosis H37Rv	2700422
Rvnt15	tRNA	Rvnt15	NC_000962.2	1113511	1113583	D	tRNA-Ala	1113511..1113583	Mycobacterium tuberculosis H37Rv	2700430
Rvnt16	tRNA	Rvnt16	NC_000962.2	1138076	1138147	R	tRNA-Gln	complement(1138076..1138147)	Mycobacterium tuberculosis H37Rv	2700462
Rvnt17	tRNA	Rvnt17	NC_000962.2	1177396	1177469	D	tRNA-Leu	1177396..1177469	Mycobacterium tuberculosis H37Rv	2700427
Rvnt18	tRNA	Rvnt18	NC_000962.2	1446193	1446265	R	tRNA-Arg	complement(1446193..1446265)	Mycobacterium tuberculosis H37Rv	2700468
Rvnt19	tRNA	Rvnt19	NC_000962.2	1512728	1512811	D	tRNA-Leu	1512728..1512811	Mycobacterium tuberculosis H37Rv	2700424
Rvnt20	tRNA	Rvnt20	NC_000962.2	1828015	1828088	R	tRNA-Leu	complement(1828015..1828088)	Mycobacterium tuberculosis H37Rv	2700456
Rvnt21	tRNA	Rvnt21	NC_000962.2	1946613	1946686	D	tRNA-Pro	1946613..1946686	Mycobacterium tuberculosis H37Rv	2700455
Rvnt22	tRNA	Rvnt22	NC_000962.2	2401987	2402072	D	tRNA-Leu	2401987..2402072	Mycobacterium tuberculosis H37Rv	2700467
Rvnt23	tRNA	Rvnt23	NC_000962.2	2510598	2510669	R	tRNA-Val	complement(2510598..2510669)	Mycobacterium tuberculosis H37Rv	2700452
Rvnt24	tRNA	Rvnt24	NC_000962.2	2581764	2581837	R	tRNA-Met	complement(2581764..2581837)	Mycobacterium tuberculosis H37Rv	2700432
Rvnt25	tRNA	Rvnt25	NC_000962.2	2619407	2619479	R	tRNA-Asn	complement(2619407..2619479)	Mycobacterium tuberculosis H37Rv	2700449
Rvnt26	tRNA	Rvnt26	NC_000962.2	2765331	2765404	R	tRNA-Pro	complement(2765331..2765404)	Mycobacterium tuberculosis H37Rv	2700470
Rvnt27	tRNA	Rvnt27	NC_000962.2	2765541	2765611	D	tRNA-Gly	2765541..2765611	Mycobacterium tuberculosis H37Rv	2700450
Rvnt28	tRNA	Rvnt28	NC_000962.2	2794176	2794249	D	tRNA-Arg	2794176..2794249	Mycobacterium tuberculosis H37Rv	2700423
Rvnt29	tRNA	Rvnt29	NC_000962.2	2827854	2827926	D	tRNA-His	2827854..2827926	Mycobacterium tuberculosis H37Rv	2700451
Rvnt30	tRNA	Rvnt30	NC_000962.2	2835494	2835566	D	tRNA-Lys	2835494..2835566	Mycobacterium tuberculosis H37Rv	2700436
Rvnt31	tRNA	Rvnt31	NC_000962.2	2969497	2969568	R	tRNA-Val	complement(2969497..2969568)	Mycobacterium tuberculosis H37Rv	2700447
Rvnt32	tRNA	Rvnt32	NC_000962.2	2969753	2969825	D	tRNA-Gly	2969753..2969825	Mycobacterium tuberculosis H37Rv	2700439
Rvnt33	tRNA	Rvnt33	NC_000962.2	2969855	2969925	D	tRNA-Cys	2969855..2969925	Mycobacterium tuberculosis H37Rv	2700440
Rvnt34	tRNA	Rvnt34	NC_000962.2	2969942	2970013	D	tRNA-Val	2969942..2970013	Mycobacterium tuberculosis H37Rv	2700437
Rvnt35	tRNA	Rvnt35	NC_000962.2	3348547	3348619	R	tRNA-Glu	complement(3348547..3348619)	Mycobacterium tuberculosis H37Rv	2700433
Rvnt36	tRNA	Rvnt36	NC_000962.2	3348659	3348730	R	tRNA-Gln	complement(3348659..3348730)	Mycobacterium tuberculosis H37Rv	2700442
Rvnt37	tRNA	Rvnt37	NC_000962.2	3431840	3431912	R	tRNA-Ala	complement(3431840..3431912)	Mycobacterium tuberculosis H37Rv	2700438
Rvnt38	tRNA	Rvnt38	NC_000962.2	3559370	3559443	R	tRNA-Met	complement(3559370..3559443)	Mycobacterium tuberculosis H37Rv	2700465
Rvnt39	tRNA	Rvnt39	NC_000962.2	4081365	4081437	R	tRNA-Thr	complement(4081365..4081437)	Mycobacterium tuberculosis H37Rv	2700461
Rvnt40	tRNA	Rvnt40	NC_000962.2	4126541	4126614	D	tRNA-Pro	4126541..4126614	Mycobacterium tuberculosis H37Rv	2700460
Rvnt41	tRNA	Rvnt41	NC_000962.2	4168345	4168430	D	tRNA-Ser	4168345..4168430	Mycobacterium tuberculosis H37Rv	2700443
Rvnt42	tRNA	Rvnt42	NC_000962.2	4199131	4199217	R	tRNA-Ser	complement(4199131..4199217)	Mycobacterium tuberculosis H37Rv	2700471
Rvnt43	tRNA	Rvnt43	NC_000962.2	4216865	4216937	R	tRNA-Arg	complement(4216865..4216937)	Mycobacterium tuberculosis H37Rv	2700457
Rvnt44	tRNA	Rvnt44	NC_000962.2	4216968	4217056	R	tRNA-Ser	complement(4216968..4217056)	Mycobacterium tuberculosis H37Rv	2700421
Rvnt45	tRNA	Rvnt45	NC_000962.2	4222581	4222667	R	tRNA-Ser	complement(4222581..4222667)	Mycobacterium tuberculosis H37Rv	2700428
Rvnr01	rRNA	rrs	NC_000962.2	1471846	1473382	D	ribosomal RNA 16S	1471846..1473382	Mycobacterium tuberculosis H37Rv	2700429
Rvnr02	rRNA	rrl	NC_000962.2	1473658	1476795	D	ribosomal RNA 23S	1473658..1476795	Mycobacterium tuberculosis H37Rv	2700466
Rvnr03	rRNA	rrf	NC_000962.2	1476899	1477013	D	ribosomal RNA 5S	1476899..1477013	Mycobacterium tuberculosis H37Rv	2700459